IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ hsu-2014-1 Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. human-fadu Homo sapiens fadu fadu ch-ip chromatin immunoprecipitation assay ch-ip q-pcr quantitative pcr q-pcr Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. ChIP results obtained using anti- H3 antibodies have not been included due to lack of antibody specificity. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation Cancer - Interactions investigated in the context of cancer hsu-2014-4 Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. human-fadu Homo sapiens fadu fadu ch-ip chromatin immunoprecipitation assay ch-ip q-pcr quantitative pcr q-pcr Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. Sequential ChIP/Re-ChIP - the target/bait of the first antibody is a prey for the second round of IP. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation Cancer - Interactions investigated in the context of cancer hsu-2014-6 Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation Cancer - Interactions investigated in the context of cancer hsu-2014-3 Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation Cancer - Interactions investigated in the context of cancer hsu-2014-8 Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. human-fadu Homo sapiens fadu fadu ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. ChIp and Sequential ChIp/Re-Chip The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation Cancer - Interactions investigated in the context of cancer hsu-2014-9 Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. in vitro In vitro deacetylase assay deacetylase assay western blot western blot Immuno blot Immuno blot Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. GST-Snail is stated to have been "purified from 293T cells cotransfected with pGST-Snail and pHA-CBP". However no details of purification are given. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation Cancer - Interactions investigated in the context of cancer hsu-2014-12 human-fadu Homo sapiens fadu fadu ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. Sequential ChIP/Re-ChIP - the target/bait of the first antibody is a prey for the second round of IP. ChIp and Sequential ChIp/Re-Chip The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation Cancer - Interactions investigated in the context of cancer hsu-2014-2 Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. human-oecm-1 OECM-1 Human Head and Neck (oral) squamous cell carcinomar cell line oecm-1 OECM-1 Human Head and Neck oral squamous cell carcinoma cell line this cell line is also known as Meng-1 anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation Cancer - Interactions investigated in the context of cancer hsu-2014-5 Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. in vitro In vitro acetylase assay acetylase assay antibody detection identification by antibody antibody detection Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. Filter Binding Assay/Dot Blot. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation Cancer - Interactions investigated in the context of cancer hsu-2014-7 Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. human-fadu Homo sapiens fadu fadu anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation Cancer - Interactions investigated in the context of cancer hsu-2014-10 Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation Cancer - Interactions investigated in the context of cancer hsu-2014-11 Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western Hsu D.S., Wang H.J., Tai S.K., Chou C.H., Hsieh C.H., Chiu P.H., Chen N.J., Yang M.H. Affinomics - Interactions curated for the Affinomics consortium. The authors state that the pFLAG-CBP and pHA-CBP constructs are of murine origin. mhyang2@vghtpe.gov.tw Cancer Cell (1535-6108) 2014 Only protein-protein interactions imex curation Cancer - Interactions investigated in the context of cancer h4_human Histone H4 H4-16 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4 HIST2H4A HIST2H4B HIST4H4 protein protein human Homo sapiens Human MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG cadh1_human_gene Human CDH1gene:Epithelial cadherin gene gene human Homo sapiens Human ercc1_human_gene DNA excision repair protein ERCC-1 ERCC1 gene gene human Homo sapiens Human snai1_human Zinc finger protein SNAI1 Protein snail homolog 1 SNAI1 SNAH protein protein human Homo sapiens Human MPRSFLVRKPSDPNRKPNYSELQDSNPEFTFQQPYDQAHLLAAIPPPEILNPTASLPMLIWDSVLAPQAQPIAWASLRLQESPRVAELTSLSDEDSGKGSQPPSPPSPAPSSFSSTSVSSLEAEAYAAFPGLGQVPKQLAQLSEAKDLQARKAFNCKYCNKEYLSLGALKMHIRSHTLPCVCGTCGKAFSRPWLLQGHVRTHTGEKPFSCPHCSRAFADRSNLRAHLQTHSDVKKYQCQACARTFSRMSLLHKHQESGCSGCPR il8_human_gene Human IL-8 gene gene gene human Homo sapiens Human tnfa_human_gene Tumor necrosis factor TNF TNFA TNFSF2 Cachectin TNF-alpha Tumor necrosis factor ligand superfamily member 2 gene gene human Homo sapiens Human ccl2_human_gene C-C motif chemokine 2 CCL2 MCP1 SCYA2 HC11 Monocyte chemoattractant protein 1 Monocyte chemotactic and activating factor Monocyte chemotactic protein 1 Monocyte secretory protein JE Small-inducible cytokine A2 gene gene human Homo sapiens Human ccl5_human_gene C-C motif chemokine 5 CCL5 D17S136E SCYA5 EoCP Eosinophil chemotactic cytokine SIS-delta Small-inducible cytokine A5 T cell-specific protein P228 T-cell-specific protein RANTES gene gene human Homo sapiens Human cbp_human CREB-binding protein CREBBP CBP Histone lysine acetyltransferase CREBBP Protein-lysine acetyltransferase CREBBP protein protein human Homo sapiens Human MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDTLEKFVEGL cbp_mouse Histone lysine acetyltransferase CREBBP Crebbp Cbp Protein-lysine acetyltransferase CREBBP protein protein mouse Mus musculus Mouse MAENLLDGPPNPKRAKLSSPGFSANDNTDFGSLFDLENDLPDELIPNGELSLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSTNMASLGAMGKSPLNQGDSSTPNLPKQAASTSGPTPPASQALNPQAQKQVGLVTSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLMNQAQQGQAQVMNGSLGAAGRGRGAGMPYPAPAMQGATSSVLAETLTQVSPQMAGHAGLNTAQAGGMTKMGMTGTTSPFGQPFSQTGGQQMGATGVNPQLASKQSMVNSLPAFPTDIKNTSVTTVPNMSQLQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGAGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPPAHQQMRTLNALGNNPMSIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGSLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPASGAQPPVIPPAQSVRPPNGPLPLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMASVPGMAISPSRMPQPPNMMGTHANNIMAQAPTQNQFLPQNQFPSSSGAMSVNSVGMGQPAAQAGVSQGQVPGAALPNPLNMLAPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHPTAPGMTPPQPAAPTQPSTPVSSGQTPTPTPGSVPSAAQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHTQPPGTPLSQAAASIDNRVPTPSSVTSAETSSQQPGPDVPMLEMKTEVQTDDAEPEPTESKGEPRSEMMEEDLQGSSQVKEETDTTEQKSEPMEVEEKKPEVKVEAKEEEENSSNDTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQNTALIAPHQIQGRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIINDYKDIFKQANEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETPEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVISTQPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHTHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVNMSPAGFPNVARTQPPTIVSAGKPTNQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRANINNGMPPGRAGMGTPGSQMTPVGLNVPRPNQVSGPVMSSMPPGQWQQAPIPQQQPMPGMPRPVMSMQAQAAVAGPRMPNVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPPQPAMGGLNPQGQALNIMNPGHNPNMTNMNPQYREMVRRQLLQHQQQQQQQQQQQQQQQNSASLAGGMAGHSQFQQPQGPGGYAPAMQQQRMQQHLPIQGSSMGQMAAPMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSMDQGHLGNPEQSAMLPQLNTPNRSALSSELSLVGDTTGDTLEKFVEGL ajuba_human LIM domain-containing protein ajuba AJUBA JUB protein protein human Homo sapiens Human MERLGEKASRLLEKFGRRKGESSRSGSDGTPGPGKGRLSGLGGPRKSGPRGATGGPGDEPLEPAREQGSLDAERNQRGSFEAPRYEGSFPAGPPPTRALPLPQSLPPDFRLEPTAPALSPRSSFASSSASDASKPSSPRGSLLLDGAGAGGAGGSRPCSNRTSGISMGYDQRHGSPLPAGPCLFGPPLAGAPAGYSPGGVPSAYPELHAALDRLYAQRPAGFGCQESRHSYPPALGSPGALAGAGVGAAGPLERRGAQPGRHSVTGYGDCAVGARYQDELTALLRLTVGTGGREAGARGEPSGIEPSGLEEPPGPFVPEAARARMREPEAREDYFGTCIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDYLFSGFQEAAEKCCVCGHLILEKILQAMGKSYHPGCFRCIVCNKCLDGIPFTVDFSNQVYCVTDYHKNYAPKCAACGQPILPSEGCEDIVRVISMDRDYHFECYHCEDCRMQLSDEEGCCCFPLDGHLLCHGCHMQRLNARQPPANYI hdac1_human Histone deacetylase 1 HDAC1 RPD3L1 protein protein human Homo sapiens Human MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA hdac2_human Histone deacetylase 2 HDAC2 protein protein human Homo sapiens Human MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP tf65_human Transcription factor p65 Nuclear factor NF-kappa-B p65 subunit RELA NFKB3 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 protein protein human Homo sapiens Human MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS sin3a_human Paired amphipathic helix protein Sin3a SIN3A Transcriptional corepressor Sin3a Histone deacetylase complex subunit Sin3a protein protein human Homo sapiens Human MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTPSYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQRLKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIMGFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQPAPQPPPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYAQVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRPSQNGCQIRRHPTGTTPPVKKKPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAYENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATEGIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSSKKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGTSEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQNEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLAYEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEEEMDVDEATGAVKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYPAFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQVTDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIELLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGREQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHERVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSINKYRVKYGTVFKAP finc_human_gene Fibronectin precursor gene gene gene human Homo sapiens Human hdac3_human Histone deacetylase 3 HDAC3 RPD3-2 SMAP45 protein protein human Homo sapiens Human MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI ep300_human Histone acetyltransferase p300 Histone butyryltransferase p300 Histone crotonyltransferase p300 Protein propionyltransferase p300 EP300 P300 E1A-associated protein p300 Protein 2-hydroxyisobutyryltransferase p300 Protein lactyltransferas p300 protein protein human Homo sapiens Human MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQTSLGMVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQVMASQAQQSSPGLGLINSMVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQPAMGMNTGMNAGMNPGMLAAGNGQGIMPNQVMNGSIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKMGMMNNPNPYGSPYTQNPGQQIGASGLGLQIQTKTVLSNNLSPFAMDKKAVPGGGMPNMGQQPAPQVQQPGLVTPVAQGMGSGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAPVGLGNPSSLGVGQQSAPNLSTVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKNQQNQQPGQSPQGMRPMSNMSASPMGVNGGVGVQTPSLLSDSMLHSAINSQNPMMSENASVPSLGPMPTAAQPSTTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKRRTRLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPNQMMPRITPQSGLNQFGQMSMAQPPIVPRQTPPLQHHGQLAQPGALNPPMGYGPRMQQPSNQGQFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAPSADQPQQQPRSQQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQVSNPPSTSSTEVNSQAIAEKQPSQEVKMEAKMEVDQPEPADTQPEDISESKVEDCKMESTETEERSTELKTEIKEEEDQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVETRWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENKCPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTPTGQQPTTPQTPQPTSQPQPTPPNSMPPYLPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPPMTPMAPMGMNPPPMTRGPSGHLEPGMGPTGMQQQPPWSQGGLPQPQQLQSGMPRPAMMSVAQHGQPLNMAPQPGLGQVGISPLKPGTVSQQALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNPQPIPGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQPQQQLQPPMGGMSPQAQQMNMNHNTMPSQFRDILRRQQMMQQQQQQGAGPGIGPGMANHNQFQQPQGVGYPPQQQQRMQHHMQQMQQGNMGQIGQLPQALGAEAGASLQAYQQRLLQQQMGSPVQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQPQPSPHHVSPQTSSPHPGLVAAQANPMEQGHFASPDQNSMLSQLASNPGMANLHGASATDLGLSTDNSDLNSNLSQSTLDIH p53_human Cellular tumor antigen p53 TP53 P53 Tumor suppressor p53 Phosphoprotein p53 Antigen NY-CO-13 protein protein human Homo sapiens Human MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD snai1-cadh1 1765936 n/a 1765948 unspecified role unspecified role bait bait arg4 nonome2arg asymmetric dimethyl-L-arginine (2S)-2-amino-5-([(dimethylamino)(imino)methyl]amino)pentanoic acid MOD_RES Asymmetric dimethylarginine MOD_RES Omega-N-methylated arginine N5-[(dimethylamino)(imino)methyl]ornithine NG,NG-dimethylarginine asymmetric dimethylarginine omega-N,omega-N-dimethlyated L-arginine omega-N,omega-N-dimethyl-L-arginine Dimethyl NoNoMe2Arg di-Methylation certain certain sequence position certain certain certain sequence position certain false n/a 1765949 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false association association false false false 1A, Supp 1B H4R3(4)Me2 is a repressive mark on CDH1 promoter associated with Snail expression. P01137 increases binding of P62805 to ENSG00000039068 TGF-beta1 -P01137 snai1-ercc1 1765936 n/a 1765950 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1765951 unspecified role unspecified role bait bait possible_acetyl_lys146 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false possible_acetyl_lys187 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false association association false false false 3E A greater enrichment of acetylated Snail was shown on the promoters of Snail-activated genes than on CDH1. Transfecting cells with non-acetylatable Snail (Snail2R) lowered gene expression.. P01375 indirectly increases expression at RNA level of ENSG00000012061 human tumor necrosis factor alpha (TNF-alpha) (P01375) CHEBI:4875 indirectly decreases expression at RNA level of ENSG00000012061 O95863 increases expression at RNA level of ENSG00000012061 crebbp-snai1-3 1765936 n/a 1765952 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1765951 unspecified role unspecified role bait bait possible_acetyl_lys146 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false possible_acetyl_lys187 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false association association false false false 3E A greater enrichment of acetylated Snail was shown on the promoters of Snail-activated genes than on CDH1. Transfecting cells with non-acetylatable Snail (Snail2R) lowered gene expression. human tumor necrosis factor alpha (TNF-alpha) (P01375) P01375 indirectly increases expression at RNA level of ENSG00000169429 O95863 increases expression at RNA level of ENSG00000169429 CHEBI:4875 indirectly decreases expression at RNA level of ENSG00000169429 CHEBI:7939 indirectly decreases expression at RNA level of ENSG00000169429 crebbp-snai1-4 1765936 n/a 1765949 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1765951 unspecified role unspecified role bait bait possible_acetyl_lys187 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false possible_acetyl_lys146 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false association association false false false 3E snai1-il8 1765936 n/a 1765951 unspecified role unspecified role bait bait n/a 1765953 unspecified role unspecified role prey prey ebox3_and_4_promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false association association false false false Supp 4J O95863 increases expression at RNA level of ENSG00000204490 CHEBI:4875 indirectly decreases expression at RNA level of ENSG00000204490 Transfecting cells with non-acetylatable Snail (Snail2R) lowered gene expression. snai1-tnf 1765936 n/a 1765954 unspecified role unspecified role prey prey ebox1-4_promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1765951 unspecified role unspecified role bait bait association association false false false Supp 4J-2 CHEBI:4875 indirectly decreases expression at RNA level of ENSG00000108691 O95863 increases expression at RNA level of ENSG00000108691 Transfecting cells with non-acetylatable Snail (Snail2R) lowered gene expression. CHEBI:7939 indirectly decreases expression at RNA level of ENSG00000108691 snai1-ccl2 1765936 n/a 1765955 unspecified role unspecified role prey prey ebox1-4_promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1765951 unspecified role unspecified role bait bait association association false false false Supp 4J-3 A greater enrichment of acetylated Snail was shown on the promoters of Snail-activated genes than on CDH1 human tumor necrosis factor alpha (TNF-alpha) (P01375) P01375 indirectly increases expression at RNA level of ENSG00000271503 CHEBI:7939 indirectly decreases expression at RNA level of ENSG00000271503 crebbp-ercc1-1 1765937 n/a 1765956 unspecified role unspecified role bait bait n/a 1765951 unspecified role unspecified role prey prey n/a 1765950 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false association association false false false 1Ei O95863 and Q92793 increases expression at RNA level of ENSG00000012061 snai1-crebbp-3 1765937 n/a 1765951 unspecified role unspecified role bait bait n/a 1765956 unspecified role unspecified role prey prey n/a 1765950 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false association association false false false 1Eii O95863 and Q92793 increases expression at RNA level of ENSG00000012061 crebbp-ercc1-2 1765937 n/a 1765956 unspecified role unspecified role bait bait n/a 1765951 unspecified role unspecified role prey prey n/a 1765952 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false association association false false false 1Eiii O95863 and Q92793 increases expression at RNA level of ENSG00000169429 snai1-crebbp-4 1765937 n/a 1765951 unspecified role unspecified role bait bait n/a 1765956 unspecified role unspecified role prey prey n/a 1765952 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false association association false false false 1Eiv O95863 and Q92793 increases expression at RNA level of ENSG00000169429 crebbp-il8-1 1765937 n/a 1765956 unspecified role unspecified role bait bait n/a 1765951 unspecified role unspecified role prey prey n/a 1765949 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false association association false false false 1Ev Snail and CBP are stated to "less frequently occupy the CDH1 promoter". snai1-cadh1-1 1765937 n/a 1765949 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1765951 unspecified role unspecified role bait bait n/a 1765956 unspecified role unspecified role prey prey association association false false false 1Evi Snail and CBP are stated to "less frequently occupy the CDH1 promoter". crebbp-snai1-1 1765938 n/a 1765957 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1765951 unspecified role unspecified role prey prey physical association physical association false false false 3A CBP and the corepressor Ajuba were not present in the same complex crebbp-snai1-2 1765938 n/a 1765958 unspecified role unspecified role bait bait region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1765951 unspecified role unspecified role prey prey physical association physical association false false false 3A-2 CBP and the corepressor Ajuba were not present in the same complex crebbp-snai1-5 1765938 n/a 1765957 unspecified role unspecified role bait bait region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1765951 unspecified role unspecified role prey prey region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false 4A Both phosphomimetic CBP (EE-CBP) and unphosphorylatable CBP (AA-CBP) interacted with Snail. snai1-ajuba 1765938 n/a 1765951 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1765958 unspecified role unspecified role prey prey n/a 1765959 unspecified role unspecified role prey prey n/a 1765960 unspecified role unspecified role prey prey association association false false false 3C Ectopic CBP inhibited the interaction between WT Snail and the corepressors (Ajuba, HDAC1, and HDAC2) but had no effect on the interaction between the nonacetylatable Snail mutant (Snail2R) and corepressors -Ajuba and Sin3A. snai1-rela-1 1765938 n/a 1765951 unspecified role unspecified role bait bait O95863:p.[Lys146Arg;Lys187Arg] mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1765961 unspecified role unspecified role prey prey physical association physical association false false false Supp 3D HA-tagged CBP was present in the experimental setup. crebbp-rela-1 1765938 n/a 1765957 unspecified role unspecified role bait bait region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1765951 anti tag western anti tag western blot anti tag western unspecified role unspecified role prey prey region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1765961 unspecified role unspecified role prey prey association association false false false Supp 3E crebbp-snai1-7 1765939 n/a 1765957 unspecified role unspecified role bait bait region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1765951 unspecified role unspecified role prey prey region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false 1D snai1-crebbp-1 1765939 n/a 1765951 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1765957 unspecified role unspecified role prey prey region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false 1D-2 snai1-crebbp-5 1765939 n/a 1765951 unspecified role unspecified role bait bait region required to bind necessary binding region required to bind certain certain sequence position certain certain certain sequence position certain false region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1765957 unspecified role unspecified role prey prey region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false Supp 1C crebbp-snai1-6 1765939 n/a 1765957 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false region_including_bromodomain_and_hat sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false n/a 1765951 unspecified role unspecified role prey prey region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false Supp 1D snai1-cadh1-2 1765940 n/a 1765949 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1765958 unspecified role unspecified role bait bait association association false false false 3D sin3a-snai1-1 1765940 n/a 1765962 unspecified role unspecified role bait bait n/a 1765949 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false association association false false false 3D-3 ajuba-cadh1-1 1765940 n/a 1765961 unspecified role unspecified role bait bait n/a 1765963 unspecified role unspecified role prey prey nfkb_binding_site_promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false association association false false false Supp 3F rela-finc-1 1765940 n/a 1765951 unspecified role unspecified role bait bait lys187 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false n/a 1765963 unspecified role unspecified role prey prey nfkb_binding_site_promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false association association false false false Supp 3F-2 hdac1-snai1 1765941 n/a 1765959 enzyme enzyme neutral component neutral component c_terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false c_terminus his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1765951 enzyme target enzyme target substrate substrate neutral component neutral component n_terminus gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false lys146 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. deacetylation deacetylation reaction deacetylation false false false 3H hdac1-snai1-1 1765941 n/a 1765960 enzyme enzyme neutral component neutral component c_terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1765951 enzyme target enzyme target substrate substrate neutral component neutral component lys187 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false lys146 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false n_terminus gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. deacetylation deacetylation reaction deacetylation false false false 3H hdac1-snai1-2 1765941 n/a 1765964 enzyme enzyme neutral component neutral component c_terminus his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1765951 enzyme target enzyme target substrate substrate neutral component neutral component lys146 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false n_terminus gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. deacetylation deacetylation reaction deacetylation false false false 3Hi positive control. Human NcoR2 (amino acids 395-489) with an N-terminal GST tag is also present. snai1-cadh1_human_gene-1 1765942 N/A 1765951 unspecified role unspecified role bait bait N/A 1765949 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1765962 unspecified role unspecified role prey prey association association false false false 3D-4 snai1-ajuba-3 1765942 N/A 1765951 unspecified role unspecified role bait bait N/A 1765949 unspecified role unspecified role prey prey promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1765958 unspecified role unspecified role prey prey association association false false false 3D-2 snai1-finc_human_gene-2 1765942 N/A 1765961 unspecified role unspecified role prey prey N/A 1765951 unspecified role unspecified role bait bait lys187 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false N/A 1765963 unspecified role unspecified role prey prey nfkb_binding_site_promoter_region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false association association false false false Supp 3F-3 snai1-crebbp 1765943 n/a 1765951 unspecified role unspecified role bait bait n/a 1765965 unspecified role unspecified role prey prey n/a 1765956 unspecified role unspecified role prey prey association association false false false 1C rela-snail 1765943 n/a 1765951 unspecified role unspecified role prey prey possible_acetyl_lys187 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false possible_acetyl_lys146 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false n/a 1765961 unspecified role unspecified role bait bait physical association physical association false false false Supp 3C ep300-snai1 1765944 n/a 1765951 enzyme target enzyme target substrate substrate neutral component neutral component region biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false O95863:p.Lys146Arg mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false chemical synthesis Chemical synthesis (Chemical synthesis) n/a 1765965 enzyme enzyme neutral component neutral component region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false hat_domain sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecoli Escherichia coli (strain K12) acetylation acetylation reaction acetylation false false false 2E ep300-snai1-1 1765944 n/a 1765965 enzyme enzyme neutral component neutral component region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false hat_domain sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecoli Escherichia coli (strain K12) n/a 1765951 enzyme target enzyme target substrate substrate neutral component neutral component zinc finger c2h2-type/integrase dna-binding domain sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false region biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false O95863:p.Lys187Arg mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false chemical synthesis Chemical synthesis (Chemical synthesis) acetylation acetylation reaction acetylation false false false 2E-2 crebbp-ep300-1 1765945 n/a 1765956 unspecified role unspecified role bait bait n/a 1765965 unspecified role unspecified role prey prey n/a 1765951 unspecified role unspecified role prey prey possible_acetyl_lys187 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false possible_acetyl_lys146 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false association association false false false 3B acetylated Snail was only present in the CBP-associated complex. sin3a-hdac1-3 1765945 n/a 1765962 unspecified role unspecified role bait bait n/a 1765960 unspecified role unspecified role prey prey n/a 1765959 unspecified role unspecified role prey prey n/a 1765951 unspecified role unspecified role prey prey association association false false false 3B-2 crebbp-tp53-4 1765946 n/a 1765956 unspecified role unspecified role neutral component neutral component n/a 1765966 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction false false false Supp Fig 2A crebbp-tp53-5 1765946 n/a 1765951 unspecified role unspecified role neutral component neutral component possible_acetyl_lys187 naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain false O95863:p.[Lys146Arg;Lys187Arg] mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false undefined mutation mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain false n/a 1765956 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction false false false Supp Fig 2B rela-crebbp-2 1765947 n/a 1765951 unspecified role unspecified role prey prey region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1765961 unspecified role unspecified role bait bait n/a 1765957 unspecified role unspecified role prey prey region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false association association false false false Supp 3E-2