IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ brenner-2011-7 Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. human-vcap Human VCaP prostate cancer cell line vcap VCaP Human prostate cancer cell line http://www.biocompare.com/ProductDetails/1838978/VCaP.html This line was established in 1997 from a vertebral bone metastasis from a patient with hormone refractory prostate cancer. It was passaged as xenografts in mice then cultured in vitro. It is androgen sensitive in vitro and in vivo. Contains the TMPRSS2�ERG gene fusion. ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. Formaldehyde was used as a cross-linking agent. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation brenner-2011-8 Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. human-rwpe Human -RWPE rwpe RWPE Non-neoplastic adult human prostatic epithelial cells from a white male donor were immortalized with human papillomavirus 18 which resulted in the establishment of the RWPE-1 cell line. ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. It is not stated which of the RWPE cell lines were used. The benign immortalized prostate epithelial cell line RWPE was infected with lentivirus expressing ERG. (Tomlins et al,. 2008) Formaldehyde was used as a cross-linking agent. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation brenner-2011-12 Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. human-vcap Human VCaP prostate cancer cell line vcap VCaP Human prostate cancer cell line http://www.biocompare.com/ProductDetails/1838978/VCaP.html This line was established in 1997 from a vertebral bone metastasis from a patient with hormone refractory prostate cancer. It was passaged as xenografts in mice then cultured in vitro. It is androgen sensitive in vitro and in vivo. Contains the TMPRSS2�ERG gene fusion. ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. Serial ChIP reactions (ERG, then PARP1 or DNA-PKcs) demonstrated that an ERG:PARP1 complex and an ERG:DNA-PKcs complex are both present at ERG-regulated loci. Re-ChIP using an antibody to PRKDC and PARP1 after a first round IP using an anti-ERG antibody. Formaldehyde was used as a cross-linking agent. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation brenner-2011-6 Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation brenner-2011-5 Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation brenner-2011-14 Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. human-pc3 Human PC3 Caucasian prostate adenocarcinoma pc3 Human Caucasian prostate adenocarcinoma ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. Formaldehyde was used as a cross-linking agent. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation brenner-2011-3 Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. human-vcap Human VCaP prostate cancer cell line vcap VCaP Human prostate cancer cell line http://www.biocompare.com/ProductDetails/1838978/VCaP.html This line was established in 1997 from a vertebral bone metastasis from a patient with hormone refractory prostate cancer. It was passaged as xenografts in mice then cultured in vitro. It is androgen sensitive in vitro and in vivo. Contains the TMPRSS2�ERG gene fusion. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation brenner-2011-10 Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. human-rwpe Human -RWPE rwpe RWPE Non-neoplastic adult human prostatic epithelial cells from a white male donor were immortalized with human papillomavirus 18 which resulted in the establishment of the RWPE-1 cell line. anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. It is not stated which of the RWPE cell lines were used. Cells were infected with adenovirus encoding V5-ERG. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation brenner-2011-1 Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. human-vcap Human VCaP prostate cancer cell line vcap VCaP Human prostate cancer cell line http://www.biocompare.com/ProductDetails/1838978/VCaP.html This line was established in 1997 from a vertebral bone metastasis from a patient with hormone refractory prostate cancer. It was passaged as xenografts in mice then cultured in vitro. It is androgen sensitive in vitro and in vivo. Contains the TMPRSS2�ERG gene fusion. anti tag coip anti tag coimmunoprecipitation anti tag coip sequence tag sequence tag identification sequence tag Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation brenner-2011-2 Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti tag coip anti tag coimmunoprecipitation anti tag coip sequence tag sequence tag identification sequence tag Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation brenner-2011-4 Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. human-prostate_carcinoma Homo sapiens prostate carcinoma prostate_carcinoma Prostate carcinoma (cancer) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation brenner-2011-9 Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. human-vcap Human VCaP prostate cancer cell line vcap VCaP Human prostate cancer cell line http://www.biocompare.com/ProductDetails/1838978/VCaP.html This line was established in 1997 from a vertebral bone metastasis from a patient with hormone refractory prostate cancer. It was passaged as xenografts in mice then cultured in vitro. It is androgen sensitive in vitro and in vivo. Contains the TMPRSS2�ERG gene fusion. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. Cells were infected with adenovirus encoding V5-ERG. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation brenner-2011-11 Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation brenner-2011-13 Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer. human-pc3 Human PC3 Caucasian prostate adenocarcinoma pc3 Human Caucasian prostate adenocarcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Brenner JC., Ateeq B., Li Y., Yocum AK., Cao Q., Asangani IA., Patel S., Wang X., Liang H., Yu J., Palanisamy N., Siddiqui J., Yan W., Cao X., Mehra R., Sabolch A., Basrur V., Lonigro RJ., Yang J., Tomlins SA., Maher CA., Elenitoba-Johnson KS., Hussain M., Navone NM., Pienta KJ., Varambally S., Feng FY., Chinnaiyan AM. Cancer - Interactions investigated in the context of cancer It is not clear if the B2Y833 tag is FLAG or V5. (Fig S1 states both Hek 293 and VCaP lines were transfected with V5-ERG, yet text at the start of the Results section states that Hek 293 was transfected with FLAG-ERG. ((HEK) 293 cells were infected with either adenoviral V5 or FLAG epitope-tagged ERG expression vectors, respectively.) Only proteins identified with probability higher than 0.95 are shown. A Trembl entry B2Y833 - for the bait (TMPRSS2 exon 1 fused to ERG exon 2), has been entered for reference only, as a translation product corresponding to the TMPRSS2/ERGb fusion transcript (GenBank: DQ204773.2) cannot be found/inferred. Exon 1 of TMPRSS2 is entirely non-coding, thus this fusion transcript most likely results in a truncated ERG protein product. (Tomlins et al., 2008) arul@umich.edu Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation fkbp5_human_gene Human FKBP5 gene gene gene human Homo sapiens Human erg_human Transcriptional regulator ERG ERG Transforming protein ERG protein protein human Homo sapiens Human MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY klk3_human_gene Human kallikrein-related peptidase 3 (KLK3) (PSA) gene gene human Homo sapiens Human tmps2_human_gene Human TMPS2/TMPRSS2 gene gene gene human Homo sapiens Human pla1a_human_gene PLA1A-Phospholipase A1 member A gene gene human Homo sapiens Human parp1_human Poly [ADP-ribose] polymerase 1 PARP1 ADPRT PPOL NAD(+) ADP-ribosyltransferase 1 Poly[ADP-ribose] synthase 1 ADP-ribosyltransferase diphtheria toxin-like 1 DNA ADP-ribosyltransferase PARP1 Protein poly-ADP-ribosyltransferase PARP1 protein protein human Homo sapiens Human MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW prkdc_human DNA-dependent protein kinase catalytic subunit PRKDC HYRC HYRC1 DNPK1 p460 protein protein human Homo sapiens Human MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFSRDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRAAKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGLLGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEEDPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKWCAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELSIAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASVLLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCISTVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQMMDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGVWMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRLPLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQYKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYIDRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNLSSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFREMKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQLYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDPVDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASLAFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEKKHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPGNRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLLLAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGNRTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPASIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPDAQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCLPSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFYSLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLATTILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLADTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYVDCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLESVYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNESTFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCYDAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFENLIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEMSQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTALVKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPYAKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLMKHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIVMANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEESLCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEVVLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVEFVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLIIRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHPLSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQQHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDFGKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSELKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEMDKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGCLASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLRGIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLDCYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQSLLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVLLHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRILELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETLSLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESYSFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTPVNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWM xrcc6_human X-ray repair cross-complementing protein 6 XRCC6 G22P1 ATP-dependent DNA helicase II 70 kDa subunit Lupus Ku autoantigen protein p70 70 kDa subunit of Ku antigen Thyroid-lupus autoantigen CTC box-binding factor 75 kDa subunit DNA repair protein XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 ATP-dependent DNA helicase 2 subunit 1 5'-deoxyribose-5-phosphate lyase Ku70 protein protein human Homo sapiens Human MSGWESYYKTEGDEEAEEEQEENLEASGDYKYSGRDSLIFLVDASKAMFESQSEDELTPFDMSIQCIQSVYISKIISSDRDLLAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELDQFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDSAKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESSKLEDLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVKTKTRTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLMGFKPLVLLKKHHYLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQEEELDDQKIQVTPPGFQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFENPVLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRAYGLKSGLKKQELLEALTKHFQD xrcc5_human X-ray repair cross-complementing protein 5 XRCC5 G22P2 ATP-dependent DNA helicase II 80 kDa subunit Lupus Ku autoantigen protein p86 86 kDa subunit of Ku antigen Ku86 Ku80 Thyroid-lupus autoantigen CTC box-binding factor 85 kDa subunit Nuclear factor IV DNA repair protein XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) ATP-dependent DNA helicase 2 subunit 2 protein protein human Homo sapiens Human MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLIEAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENFRVLVKQKKASFEEASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLKALQEKVEIKQLNHFWEIVVQDGITLITKEEASGSSVTAEEAKKFLAPKDKPSGDTAAVFEEGGDVDDLLDMI p11308-1 Transcriptional regulator ERG ERG Transforming protein ERG ERG-2 protein protein human Homo sapiens Human MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY ets1_human Protein C-ets-1 p54 ETS1 EWSR2 protein protein human Homo sapiens Human MKAAVDLKPTLTIIKTEKVDLELFPSPDMECADVPLLTPSSKEMMSQALKATFSGFTKEQQRLGIPKDPRQWTETHVRDWVMWAVNEFSLKGVDFQKFCMNGAALCALGKDCFLELAPDFVGDILWEHLEILQKEDVKPYQVNGVNPAYPESRYTSDYFISYGIEHAQCVPPSEFSEPSFITESYQTLHPISSEELLSLKYENDYPSVILRDPLQTDTLQNDYFAIKQEVVTPDNMCMGRTSRGKLGGQDSFESIESYDSCDRLTQSWSSQSSFNSLQRVPSYDSFDSEDYPAALPNHKPKGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHAMLDVKPDADE etv1_human ETS translocation variant 1 ETV1 ER81 Ets-related protein 81 protein protein human Homo sapiens Human MDGFYDQQVPYMVTNSQRGRNCNEKPTNVRKRKFINRDLAHDSEELFQDLSQLQETWLAEAQVPDNDEQFVPDYQAESLAFHGLPLKIKKEPHSPCSEISSACSQEQPFKFSYGEKCLYNVSAYDQKPQVGMRPSNPPTPSSTPVSPLHHASPNSTHTPKPDRAFPAHLPPSQSIPDSSYPMDHRFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYVY spi1_human Transcription factor PU.1 SPI1 31 kDa-transforming protein protein protein human Homo sapiens Human MLQACKMEGFPLVPPPSEDLVPYDTDLYQRQTHEYYPYLSSDGESHSDHYWDFHPHHVHSEFESFAENNFTELQSVQPPQLQQLYRHMELEQMHVLDTPMVPPHPSLGHQVSYLPRMCLQYPSLSPAQPSSDEEEGERQSPPLEVSDGEADGLEPGPGLLPGETGSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKVKKKLTYQFSGEVLGRGGLAERRHPPH p11308-4 Transcriptional regulator ERG ERG Transforming protein ERG protein protein human Homo sapiens Human MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY b2y833_human ERG protein protein human Homo sapiens Human MTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPVSYR prp8_human Pre-mRNA-processing-splicing factor 8 Splicing factor Prp8 PRP8 homolog 220 kDa U5 snRNP-specific protein p220 PRPC8 PRPF8 protein protein human Homo sapiens Human MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKEDMPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLYHITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYRLANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDINKIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPISHRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRRALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATKFFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQFEGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCWKANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLILALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMDLYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGINNLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYKDMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATEAAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKCRTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFIDSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRTDFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSYKMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYARAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPALYVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVEVQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLTATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKETGYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLPGQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTPGSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWNYNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA ddx3x_human ATP-dependent RNA helicase DDX3X DDX3X DBX DDX3 DEAD box protein 3, X-chromosomal Helicase-like protein 2 DEAD box, X isoform CAP-Rf protein protein human Homo sapiens Human MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN pcbp1_human Poly(rC)-binding protein 1 PCBP1 Alpha-CP1 Nucleic acid-binding protein SUB2.3 Heterogeneous nuclear ribonucleoprotein E1 protein protein human Homo sapiens Human MDAGVTESGLNVTLTIRLLMHGKEVGSIIGKKGESVKRIREESGARINISEGNCPERIITLTGPTNAIFKAFAMIIDKLEEDINSSMTNSTAASRPPVTLRLVVPATQCGSLIGKGGCKIKEIRESTGAQVQVAGDMLPNSTERAITIAGVPQSVTECVKQICLVMLETLSQSPQGRVMTIPYQPMPASSPVICAGGQDRCSDAAGYPHATHDLEGPPLDAYSIQGQHTISPLDLAKLNQVARQQSHFAMMHGGTGFAGIDSSSPEVKGYWASLDASTQTTHELTIPNNLIGCIIGRQGANINEIRQMSGAQIKIANPVEGSSGRQVTITGSAASISLAQYLINARLSSEKGMGCS roa2_human Heterogeneous nuclear ribonucleoproteins A2/B1 HNRNPA2B1 HNRPA2B1 protein protein human Homo sapiens Human MEKTLETVPLERKKREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGGGNFGGSPGYGGGRGGYGGGGPGYGNQGGGYGGGYDNYGGGNYGSGNYNDFGNYNQQPSNYGPMKSGNFGGSRNMGGPYGGGNYGPGGSGGSGGYGGRSRY ddx5_human Probable ATP-dependent RNA helicase DDX5 HLR1 DDX5 HELR G17P1 DEAD box protein 5 RNA helicase p68 protein protein human Homo sapiens Human MSGYSSDRDRGRDRGFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGNPTGTYQNGYDSTQQYGSNVPNMHNGMNQQAYAYPATAAAPMIGYPMPTGYSQ b7z722_human TPM1 hCG_33495 protein protein human Homo sapiens Human MAGSSSLEAVRRKIRSLQEQADAAEERAGTLQRELDHERKLRETAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM p19474-1 E3 ubiquitin-protein ligase TRIM21 TRIM21 RNF81 52 kDa ribonucleoprotein autoantigen Ro/SS-A RING finger protein 81 Ro(SS-A) Sjoegren syndrome type A antigen Tripartite motif-containing protein 21 52 kDa Ro protein RO52 SSA1 52alpha Ro52alpha RING-type E3 ubiquitin transferase TRIM21 protein protein human Homo sapiens Human MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY hnrpm_human Heterogeneous nuclear ribonucleoprotein M HNRNPM HNRPM NAGR1 protein protein human Homo sapiens Human MAAGVEAAAEVAATEIKMEEESGAPGVPSGNGAPGPKGEGERPAQNEKRKEKNIKRGGNRFEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTGGMGMGPGGPGMITIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLNKGIGMGNIGPAGMGMEGIGFGINKMGGMEGPFGGGMENMGRFGSGMNMGRINEILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA if2a_human Eukaryotic translation initiation factor 2 subunit 1 EIF2S1 EIF2A Eukaryotic translation initiation factor 2 subunit alpha protein protein human Homo sapiens Human MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQMERLERENAEVDGDDDAEEMEAKAED rla0_human 60S acidic ribosomal protein P0 RPLP0 60S ribosomal protein L10E Large ribosomal subunit protein uL10 protein protein human Homo sapiens Human MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILSDVQLIKTGDKVGASEATLLNMLNISPFSFGLVIQQVFDNGSIYNPEVLDITEETLHSRFLEGVRNVASVCLQIGYPTVASVPHSIINGYKRVLALSVETDYTFPLAEKVKAFLADPSAFVAAAPVAAATTAAPAAAAAPAKVEAKEESEESDEDMGFGLFD hnrdl_human Heterogeneous nuclear ribonucleoprotein D-like HNRNPDL AU-rich element RNA-binding factor HNRPDL JKT41-binding protein JKTBP Protein laAUF1 protein protein human Homo sapiens Human MEVPPRLSHVPPPLFPSAPATLASRSLSHWRPRPPRQLAPLLPSLAPSSARQGARRAQRHVTAQQPSRLAGGAAIKGGRRRRPDLFRRHFKSSSIQRSAAAAAATRTARQHPPADSSVTMEDMNEYSNIEEFAEGSKINASKNQQDDGKMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVDKVLELKEHKLDGKLIDPKRAKALKGKEPPKKVFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTKTNERRGFCFITYTDEEPVKKLLESRYHQIGSGKCEIKVAQPKEVYRQQQQQQKGGRGAAAGGRGGTRGRGRGQGQNWNQGFNNYYDQGYGNYNSAYGGDQNYSGYGGYDYTGYNYGNYGYGQGYADYSGQQSTYGKASRGGGNHQNNYQPY tbb5_human Tubulin beta chain TUBB Tubulin beta-5 chain TUBB5 OK/SW-cl.56 protein protein human Homo sapiens Human MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEEDFGEEAEEEA rl7a_human 60S ribosomal protein L7a RPL7A SURF-3 SURF3 Surfeit locus protein 3 PLA-X polypeptide Large ribosomal subunit protein eL8 protein protein human Homo sapiens Human MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCIIKGKARLGRLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG pyr1_human CAD protein CAD protein protein human Homo sapiens Human MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNYGIPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVDTRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILALDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVLSEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVETDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEATAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEIEYEVVRDAYGNCVTVCNMENLDPLGIHTGESIVVAPSQTLNDREYQLLRQTAIKVTQHLGIVGECNVQYALNPESEQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNSVTGGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMVDENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGVKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNETFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEILLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVIDCFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDPGLPAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGTPGLLHPQTSPLLHSLVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFAAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSLRYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEACFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATVLGRF atpa_human ATP synthase subunit alpha, mitochondrial ATP5F1A ATP synthase F1 subunit alpha ATP5A ATP5A1 ATP5AL2 ATPM protein protein human Homo sapiens Human MLSVRVAAAVVRALPRRAGLVSRNALGSSFIAARNFHASNTHLQKTGTAEMSSILEERILGADTSVDLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGLKGMSLNLEPDNVGVVVFGNDKLIKEGDIVKRTGAIVDVPVGEELLGRVVDALGNAIDGKGPIGSKTRRRVGLKAPGIIPRISVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGKTSIAIDTIINQKRFNDGSDEKKKLYCIYVAIGQKRSTVAQLVKRLTDADAMKYTIVVSATASDAAPLQYLAPYSGCSMGEYFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDAFGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTRAMKQVAGTMKLELAQYREVAAFAQFGSDLDAATQQLLSRGVRLTELLKQGQYSPMAIEEQVAVIYAGVRGYLDKLEPSKITKFENAFLSHVVSQHQALLGTIRADGKISEQSDAKLKEIVTNFLAGFEA rs18_human 40S ribosomal protein S18 RPS18 D6S218E Ke-3 Small ribosomal subunit protein uS13 protein protein human Homo sapiens Human MSLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLTKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANGLDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRTVGVSKKK hnrpu_human Heterogeneous nuclear ribonucleoprotein U HNRNPU SAFA U21.1 HNRPU p120 pp120 C1orf199 GRIP120 Nuclear p120 ribonucleoprotein Scaffold-attachment factor A protein protein human Homo sapiens Human MSSSPVNVKKLKVSELKEELKKRRLSDKGLKAELMERLQAALDDEEAGGRPAMEPGNGSLDLGGDSAGRSGAGLEQEAAAGGDEEEEEEEEEEEGISALDGDQMELGEENGAAGAADSGPMEEEEAASEDENGDDQGFQEGEDELGDEEEGAGDENGHGEQQPQPPATQQQQPQQQRGAAKEAAGKSSGPTSLFAVTVAPPGARQGQQQAGGKKKAEGGGGGGRPGAPAAGDGKTEQKGGDKKRGVKRPREDHGRGYFEYIEENKYSRAKSPQPPVEEEDEHFDDTVVCLDTYNCDLHFKISRDRLSASSLTMESFAFLWAGGRASYGVSKGKVCFEMKVTEKIPVRHLYTKDIDIHEVRIGWSLTTSGMLLGEEEFSYGYSLKGIKTCNCETEDYGEKFDENDVITCFANFESDEVELSYAKNGQDLGVAFKISKEVLAGRPLFPHVLCHNCAVEFNFGQKEKPYFPIPEEYTFIQNVPLEDRVRGPKGPEEKKDCEVVMMIGLPGAGKTTWVTKHAAENPGKYNILGTNTIMDKMMVAGFKKQMADTGKLNTLLQRAPQCLGKFIEIAARKKRNFILDQTNVSAAAQRRKMCLFAGFQRKAVVVCPKDEDYKQRTQKKAEVEGKDLPEHAVLKMKGNFTLPEVAECFDEITYVELQKEEAQKLLEQYKEESKKALPPEKKQNTGSKKSNKNKSGKNQFNRGGGHRGRGGFNMRGGNFRGGAPGNRGGYNRRGNMPQRGGGGGGSGGIGYPYPRAPVFPGRGSYSNRGNYNRGGMPNRGNYNQNFRGRGNNRGYKNQSQGYNQWQQGQFWGQKPWSQHYHQGYY sptn1_human Spectrin alpha chain, non-erythrocytic 1 SPTAN1 SPTA2 Alpha-II spectrin Fodrin alpha chain NEAS Spectrin, non-erythroid alpha subunit protein protein human Homo sapiens Human MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRELPTAFDYVEFTRSLFVN p78527-1 DNA-dependent protein kinase catalytic subunit PRKDC HYRC HYRC1 DNPK1 p460 protein protein human Homo sapiens Human MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFSRDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRAAKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGLLGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEEDPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKWCAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELSIAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASVLLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCISTVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQMMDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGVWMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRLPLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQYKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYIDRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNLSSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFREMKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQLYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDPVDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASLAFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEKKHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPGNRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLLLAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGNRTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPASIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPDAQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCLPSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFYSLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLATTILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLADTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYVDCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLESVYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNESTFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCYDAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFENLIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEMSQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTALVKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPYAKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLMKHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIVMANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEESLCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEVVLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVEFVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLIIRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHPLSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQQHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDFGKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSELKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEMDKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGCLASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLRGIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLDCYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQSLLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVLLHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRILELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETLSLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESYSFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTPVNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWM erg-fkbp5-1 1157157 n/a 1157171 unspecified role unspecified role prey prey n/a 1157172 unspecified role unspecified role bait bait association association false false false Fig 2A,S2A. ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. erg-klk3-2 1157157 n/a 1157173 unspecified role unspecified role prey prey n/a 1157172 unspecified role unspecified role bait bait association association false false false Fig 2A, S2A. ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. erg-tmps2-1 1157157 n/a 1157172 unspecified role unspecified role bait bait n/a 1157174 unspecified role unspecified role prey prey association association false false false Fig 2A, S2A. ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. erg-pla1a 1157157 n/a 1157172 unspecified role unspecified role bait bait n/a 1157175 unspecified role unspecified role prey prey association association false false false Fig 2A, S2A. ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. parp1-pla1a 1157157 n/a 1157175 unspecified role unspecified role prey prey n/a 1157176 unspecified role unspecified role bait bait association association false false false Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. parp1-fkbp5 1157157 n/a 1157171 unspecified role unspecified role prey prey n/a 1157176 unspecified role unspecified role bait bait association association false false false Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. parp1-klk3 1157157 n/a 1157173 unspecified role unspecified role prey prey n/a 1157176 unspecified role unspecified role bait bait association association false false false Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. parp1-tmps2 1157157 n/a 1157174 unspecified role unspecified role prey prey n/a 1157176 unspecified role unspecified role bait bait association association false false false Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. prkdc-klk3 1157157 n/a 1157173 unspecified role unspecified role prey prey n/a 1157177 unspecified role unspecified role bait bait association association false false false Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. prkdc-fkbp5 1157157 n/a 1157177 unspecified role unspecified role bait bait n/a 1157171 unspecified role unspecified role prey prey association association false false false Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. prkdc-tmps2 1157157 n/a 1157177 unspecified role unspecified role bait bait n/a 1157174 unspecified role unspecified role prey prey association association false false false Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. prkdc-pla1a 1157157 n/a 1157177 unspecified role unspecified role bait bait n/a 1157175 unspecified role unspecified role prey prey association association false false false Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc6-tmps2 1157157 n/a 1157178 unspecified role unspecified role bait bait n/a 1157174 unspecified role unspecified role prey prey association association false false false Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc6-fkbp5 1157157 n/a 1157171 unspecified role unspecified role prey prey n/a 1157178 unspecified role unspecified role bait bait association association false false false Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc6-klk3 1157157 n/a 1157178 unspecified role unspecified role bait bait n/a 1157173 unspecified role unspecified role prey prey association association false false false Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc6-pla1a 1157157 n/a 1157178 unspecified role unspecified role bait bait n/a 1157175 unspecified role unspecified role prey prey association association false false false Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc5-pla1a 1157157 n/a 1157179 unspecified role unspecified role bait bait n/a 1157175 unspecified role unspecified role prey prey association association false false false Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc5-fkbp5 1157157 n/a 1157171 unspecified role unspecified role prey prey n/a 1157179 unspecified role unspecified role bait bait association association false false false Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc5-klk3 1157157 n/a 1157179 unspecified role unspecified role bait bait n/a 1157173 unspecified role unspecified role prey prey association association false false false Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc5-tmps2 1157157 n/a 1157179 unspecified role unspecified role bait bait n/a 1157174 unspecified role unspecified role prey prey association association false false false Fig 2A, S2A. DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. prkdc-fkbp5-1 1157158 n/a 1157177 unspecified role unspecified role bait bait n/a 1157171 unspecified role unspecified role prey prey association association false false false Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc6-pla1a-1 1157158 n/a 1157178 unspecified role unspecified role bait bait n/a 1157175 unspecified role unspecified role prey prey association association false false false Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. erg-tmps2-2 1157158 n/a 1157172 unspecified role unspecified role bait bait n/a 1157174 unspecified role unspecified role prey prey association association false false false Fig 2A ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. prkdc-tmps2-1 1157158 n/a 1157177 unspecified role unspecified role bait bait n/a 1157174 unspecified role unspecified role prey prey association association false false false Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc6-tmps2-1 1157158 n/a 1157178 unspecified role unspecified role bait bait n/a 1157174 unspecified role unspecified role prey prey association association false false false Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. parp1-tmps2-1 1157158 n/a 1157174 unspecified role unspecified role prey prey n/a 1157176 unspecified role unspecified role bait bait association association false false false Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. erg-pla1a-1 1157158 n/a 1157172 unspecified role unspecified role bait bait n/a 1157175 unspecified role unspecified role prey prey association association false false false Fig 2A ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc5-pla1a-1 1157158 n/a 1157179 unspecified role unspecified role bait bait n/a 1157175 unspecified role unspecified role prey prey association association false false false Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc6-fkbp5-1 1157158 n/a 1157178 unspecified role unspecified role bait bait n/a 1157171 unspecified role unspecified role prey prey association association false false false Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. erg-klk3-3 1157158 n/a 1157172 unspecified role unspecified role bait bait n/a 1157173 unspecified role unspecified role prey prey association association false false false Fig 2A ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. prkdc-pla1a-1 1157158 n/a 1157175 unspecified role unspecified role prey prey n/a 1157177 unspecified role unspecified role bait bait association association false false false Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. parp1-klk3-1 1157158 n/a 1157173 unspecified role unspecified role prey prey n/a 1157176 unspecified role unspecified role bait bait association association false false false Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. parp1-fkbp5-1 1157158 n/a 1157176 unspecified role unspecified role bait bait n/a 1157171 unspecified role unspecified role prey prey association association false false false Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc5-tmps2-1 1157158 n/a 1157179 unspecified role unspecified role bait bait n/a 1157174 unspecified role unspecified role prey prey association association false false false Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. parp1-pla1a-1 1157158 n/a 1157175 unspecified role unspecified role prey prey n/a 1157176 unspecified role unspecified role bait bait association association false false false Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc5-klk3-1 1157158 n/a 1157179 unspecified role unspecified role bait bait n/a 1157173 unspecified role unspecified role prey prey association association false false false Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc6-klk3-1 1157158 n/a 1157178 unspecified role unspecified role bait bait n/a 1157173 unspecified role unspecified role prey prey association association false false false Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. erg-fkbp5-2 1157158 n/a 1157172 unspecified role unspecified role bait bait n/a 1157171 unspecified role unspecified role prey prey association association false false false Fig 2A ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. prkdc-klk3-1 1157158 n/a 1157173 unspecified role unspecified role prey prey n/a 1157177 unspecified role unspecified role bait bait association association false false false Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. xrcc5-fkbp5-1 1157158 n/a 1157171 unspecified role unspecified role prey prey n/a 1157179 unspecified role unspecified role bait bait association association false false false Fig 2A DNA-PKcs, Ku70, Ku80, and PARP1 bind to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. parp1-klk3 1157159 n/a 1157172 unspecified role unspecified role prey prey n/a 1157176 unspecified role unspecified role bait bait n/a 1157173 unspecified role unspecified role prey prey association association false false false Fig S2C. parp1-pla1a 1157159 n/a 1157172 unspecified role unspecified role prey prey n/a 1157176 unspecified role unspecified role bait bait n/a 1157175 unspecified role unspecified role prey prey association association false false false Fig S2C parp1-fkbp5 1157159 n/a 1157171 unspecified role unspecified role prey prey n/a 1157172 unspecified role unspecified role prey prey n/a 1157176 unspecified role unspecified role bait bait association association false false false Fig S2C. parp1-tmps2 1157159 n/a 1157174 unspecified role unspecified role prey prey n/a 1157172 unspecified role unspecified role prey prey n/a 1157176 unspecified role unspecified role bait bait association association false false false Fig S2C prkdc-tmps2 1157159 n/a 1157177 unspecified role unspecified role bait bait n/a 1157174 unspecified role unspecified role prey prey n/a 1157172 unspecified role unspecified role prey prey association association false false false Fig S2C prkdc-pla1a 1157159 n/a 1157175 unspecified role unspecified role prey prey n/a 1157177 unspecified role unspecified role bait bait n/a 1157172 unspecified role unspecified role prey prey association association false false false Fig S2C prkdc-klk3 1157159 n/a 1157173 unspecified role unspecified role prey prey n/a 1157172 unspecified role unspecified role prey prey n/a 1157177 unspecified role unspecified role bait bait association association false false false Fig S2C prkdc-fkbp5 1157159 n/a 1157177 unspecified role unspecified role bait bait n/a 1157172 unspecified role unspecified role prey prey n/a 1157171 unspecified role unspecified role prey prey association association false false false Fig S2C erg-prkdc 1157160 n/a 1157180 unspecified role unspecified role bait bait halo-biotin-tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false partial_ets_domain required to bind necessary binding region required to bind range range range range false P11308-1:p.Tyr356Ala mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain false in vitro In vitro n/a 1157177 unspecified role unspecified role prey prey human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 direct interaction direct interaction false false false Fig 1F, S1M, S1N, S1P. The interaction was localised to the final 28 amino acids of the ETS domain. The mutation stated to be Y373A (as can be found in P11308-4) has been entered as Y356A - which corresponds to the same amino acid in isoform P11308-1 (as shown in Fig 1). ets1-prkdc 1157160 n/a 1157181 unspecified role unspecified role bait bait halo-biotin-tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false in vitro In vitro n/a 1157177 unspecified role unspecified role prey prey human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 direct interaction direct interaction false false false Fig S1M etv1-prkdc 1157160 n/a 1157177 unspecified role unspecified role prey prey human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 n/a 1157182 unspecified role unspecified role bait bait halo-biotin-tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false in vitro In vitro direct interaction direct interaction false false false Fig S1M spi1-prkdc 1157160 n/a 1157177 unspecified role unspecified role prey prey human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 n/a 1157183 unspecified role unspecified role bait bait halo-biotin-tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false in vitro In vitro direct interaction direct interaction false false false Fig S1M erg-parp1 1157160 n/a 1157176 unspecified role unspecified role prey prey ecoli Escherichia coli (strain K12) n/a 1157180 unspecified role unspecified role bait bait partial_ets_domain required to bind necessary binding region required to bind range range range range false halo-biotin-tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false in vitro In vitro direct interaction direct interaction false false false Fig S1O. The interaction was localised to the final 28 amino acids of the ETS domain. Ethidium bromide -purified ERG was only able to interact with purified PARP1 in the absence of ethidium bromide. erg 1157161 n/a 1157184 unspecified role unspecified role bait bait c_terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged certain certain sequence position certain certain certain sequence position certain false region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false n/a 1157176 unspecified role unspecified role prey prey n/a 1157178 unspecified role unspecified role prey prey n/a 1157179 unspecified role unspecified role prey prey n/a 1157177 unspecified role unspecified role prey prey association association false false false Fig 1E ets1-parp1 1157161 n/a 1157181 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1157176 unspecified role unspecified role prey prey n/a 1157177 unspecified role unspecified role prey prey n/a 1157178 unspecified role unspecified role prey prey n/a 1157179 unspecified role unspecified role prey prey association association false false false Fig S1J spi1-parp1 1157161 n/a 1157177 unspecified role unspecified role prey prey n/a 1157179 unspecified role unspecified role prey prey n/a 1157176 unspecified role unspecified role prey prey n/a 1157178 unspecified role unspecified role prey prey n/a 1157183 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false association association false false false Fig S1K etv1-parp1 1157161 n/a 1157178 unspecified role unspecified role prey prey n/a 1157176 unspecified role unspecified role prey prey n/a 1157179 unspecified role unspecified role prey prey n/a 1157177 unspecified role unspecified role prey prey n/a 1157182 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false association association false false false Fig S1L erg-tmps2-3 1157162 n/a 1157174 unspecified role unspecified role prey prey n/a 1157172 unspecified role unspecified role bait bait association association false false false Fig S5E ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. erg-fkbp5-3 1157162 n/a 1157171 unspecified role unspecified role prey prey n/a 1157172 unspecified role unspecified role bait bait association association false false false Fig S5E ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. erg-klk3-4 1157162 n/a 1157172 unspecified role unspecified role bait bait n/a 1157173 unspecified role unspecified role prey prey association association false false false Fig S5E ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. erg-pla1a-2 1157162 n/a 1157175 unspecified role unspecified role prey prey n/a 1157172 unspecified role unspecified role bait bait association association false false false Fig S5E ERG bound to the PLA1A promoter and the FKBP5, PSA, and TMPRSS2 enhancers. b2y833-erg-3 1157163 n/a 1157177 unspecified role unspecified role prey prey n/a 1157179 unspecified role unspecified role prey prey n/a 1157178 unspecified role unspecified role prey prey n/a 1157176 unspecified role unspecified role prey prey n/a 1157172 unspecified role unspecified role prey prey n/a 1157185 unspecified role unspecified role bait bait association association false false false Fig 1B, S1C. Ethidium bromide treatment disrupted the interaction between ERG, Ku70, and Ku80, but not the interaction between ERG and either PARP1 or DNA-PKcs. parp1-lots 1157163 n/a 1157172 unspecified role unspecified role prey prey n/a 1157185 unspecified role unspecified role prey prey n/a 1157176 unspecified role unspecified role bait bait n/a 1157177 unspecified role unspecified role prey prey n/a 1157179 unspecified role unspecified role prey prey association association false false false Fig S1E. prkdc-parp1 1157163 n/a 1157178 unspecified role unspecified role prey prey n/a 1157176 unspecified role unspecified role prey prey n/a 1157177 unspecified role unspecified role bait bait association association false false false Fig S2D. PARP1 and DNA-PKcs interact in a DNA-independent manner in VCaP cells. (in the presence of Ethidium bromide there was no interaction observed between DNA-PKcs and Ku70.) prkdc-erg 1157164 n/a 1157177 unspecified role unspecified role bait bait n/a 1157176 unspecified role unspecified role prey prey n/a 1157172 unspecified role unspecified role prey prey region v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false association association false false false Fig S1D parp1-erg 1157164 n/a 1157172 unspecified role unspecified role prey prey region v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1157176 unspecified role unspecified role bait bait physical association physical association false false false Fig S1D xrcc5-erg 1157164 n/a 1157179 unspecified role unspecified role bait bait n/a 1157172 unspecified role unspecified role prey prey region v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1157176 unspecified role unspecified role prey prey association association false false false Fig S1D b2y833-erg 1157165 n/a 1157186 unspecified role unspecified role prey prey n/a 1157187 unspecified role unspecified role prey prey n/a 1157188 unspecified role unspecified role prey prey n/a 1157189 unspecified role unspecified role prey prey n/a 1157190 unspecified role unspecified role prey prey n/a 1157191 unspecified role unspecified role prey prey n/a 1157192 unspecified role unspecified role prey prey n/a 1157193 unspecified role unspecified role prey prey n/a 1157194 unspecified role unspecified role prey prey n/a 1157195 unspecified role unspecified role prey prey n/a 1157196 unspecified role unspecified role prey prey n/a 1157197 unspecified role unspecified role prey prey n/a 1157198 unspecified role unspecified role prey prey n/a 1157199 unspecified role unspecified role prey prey n/a 1157200 unspecified role unspecified role prey prey n/a 1157201 unspecified role unspecified role prey prey n/a 1157202 unspecified role unspecified role prey prey n/a 1157179 unspecified role unspecified role prey prey n/a 1157178 unspecified role unspecified role prey prey n/a 1157203 unspecified role unspecified role prey prey n/a 1157204 unspecified role unspecified role prey prey n/a 1157172 unspecified role unspecified role prey prey n/a 1157185 unspecified role unspecified role bait bait region v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false association association false false false Fig 1A/S1A/TABLE S1 b2y833-erg-1 1157166 n/a 1157186 unspecified role unspecified role prey prey n/a 1157201 unspecified role unspecified role prey prey n/a 1157191 unspecified role unspecified role prey prey n/a 1157199 unspecified role unspecified role prey prey n/a 1157187 unspecified role unspecified role prey prey n/a 1157198 unspecified role unspecified role prey prey n/a 1157196 unspecified role unspecified role prey prey n/a 1157172 unspecified role unspecified role prey prey n/a 1157193 unspecified role unspecified role prey prey n/a 1157179 unspecified role unspecified role prey prey n/a 1157203 unspecified role unspecified role prey prey n/a 1157195 unspecified role unspecified role prey prey n/a 1157202 unspecified role unspecified role prey prey n/a 1157192 unspecified role unspecified role prey prey n/a 1157188 unspecified role unspecified role prey prey n/a 1157190 unspecified role unspecified role prey prey n/a 1157200 unspecified role unspecified role prey prey n/a 1157197 unspecified role unspecified role prey prey n/a 1157189 unspecified role unspecified role prey prey n/a 1157194 unspecified role unspecified role prey prey n/a 1157185 unspecified role unspecified role bait bait v5_or_flag_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1157204 unspecified role unspecified role prey prey n/a 1157178 unspecified role unspecified role prey prey association association false false false Fig 1A/S1A/TABLE S1 b2y833-erg-4 1157167 n/a 1157178 unspecified role unspecified role prey prey n/a 1157185 unspecified role unspecified role bait bait n/a 1157176 unspecified role unspecified role prey prey n/a 1157179 unspecified role unspecified role prey prey n/a 1157177 unspecified role unspecified role prey prey association association false false false Fig 1C, S1F, S1H. ERG-IP showed enrichment for DNA-PKcs, Ku70, Ku80, and PARP1 in ERG gene fusion-positive, but not in ETS gene fusion-negative, prostate cancer tissues. The interaction between ERG and PAPRP1 occurred in the absence of DNA (in the presence of ethidium bromide) in all three independent human (prostate cancer) tissues (Figure S1H). b2y833-erg-5 1157168 n/a 1157179 unspecified role unspecified role prey prey n/a 1157172 unspecified role unspecified role bait bait region v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1157178 unspecified role unspecified role prey prey n/a 1157185 unspecified role unspecified role prey prey n/a 1157177 unspecified role unspecified role prey prey association association false false false Supp. Fig 1B Ethidium bromide treatment disrupted the interaction between ERG, Ku70, and Ku80, but not the interaction between ERG and either PARP1 or DNA-PKcs. erg-parp1 1157169 n/a 1157172 unspecified role unspecified role bait bait n/a 1157177 unspecified role unspecified role prey prey n/a 1157176 unspecified role unspecified role prey prey association association false false false Fig S1G b2y833-erg-6 1157170 n/a 1157177 unspecified role unspecified role prey prey n/a 1157179 unspecified role unspecified role prey prey n/a 1157178 unspecified role unspecified role prey prey n/a 1157185 unspecified role unspecified role bait bait n/a 1157176 unspecified role unspecified role prey prey association association false false false Fig S5D IP-western confirmed the ERG:DNA-PKcs and ERG:PARP1 interactions.