IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ wilson-2008-3 FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. human-bd220 Homo sapiens Fanconi anaemia cell line BD220 (FA-A) bd220 Fanconi anaemia cell line BD220 (FA-A) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Oncogene (0950-9232) 2008 Only protein-protein interactions imex curation wilson-2008-4 FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. human-bd215 Homo sapiens Fanconi anaemia cell lines BD215 (FA-C) bd215 Human Fanconi anaemia cell lines BD215 (FA-C) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Oncogene (0950-9232) 2008 Only protein-protein interactions imex curation wilson-2008-5 FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. human-eufa409 Homo sapiens Fanconi anaemia cell lines EUFA409 (FA-E) eufa409 Human Fanconi anaemia cell lines EUFA409 (FA-E) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Oncogene (0950-9232) 2008 Only protein-protein interactions imex curation wilson-2008-6 FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. human-eufa121 Homo sapiens Fanconi anaemia cell lines EUFA121 (FA-F) eufa121 Human Fanconi anaemia cell line EUFA121 (FA-F) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Oncogene (0950-9232) 2008 Only protein-protein interactions imex curation wilson-2008-11 FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. human-pd20 Homo sapiens Fanconi anaemia cell line PD20 (FA-D2) pd20 Human Fanconi anaemia cell line PD20 (FA-D2) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Oncogene (0950-9232) 2008 Only protein-protein interactions imex curation wilson-2008-12 FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. human-hcs72 Homo sapiens Fanconi anaemia cell line HCS72 (FA-A) hcs72 Human Fanconi anaemia cell line HCS72 (FA-A) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Oncogene (0950-9232) 2008 Only protein-protein interactions imex curation wilson-2008-15 FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. crigr-40bp6 Cricetulus griseus ovary derived cells (FANCG-corrected) 40bp6 Chinese hamster ovary cell derived cell line 40BP6 (FANCG-corrected) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Oncogene (0950-9232) 2008 Only protein-protein interactions imex curation wilson-2008-1 FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Oncogene (0950-9232) 2008 Only protein-protein interactions imex curation wilson-2008-2 FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. human-3a_tpa_30_1 Homo sapiens 3A(tPA-30-1) cell line 3a_tpa_30_1 Human placental cell line 3A(tPA-30-1) ( transformed by SV40 ts30) This is a hypodiploid human cell line with the modal chromosome number of 42 occurring in 34% of cells. However, cells with 44 chromosomes also occurred at a high frequency (26%). Most cells contained 41-45 chromosomes. Cells having a higher ploidy occurred at 20.7%, which is very high. Most cells averaged five or six marker chromosomes, none of which appeared twice in the cells examined. No chromosomes were paired consistently. (The cells are sometimes referred by the ATCC catalogue no. CRL-1583. However, these catalogue nos are not stable identifiers). anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Oncogene (0950-9232) 2008 Only protein-protein interactions imex curation wilson-2008-7 FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. human-326v Homo sapiens Fanconi anaemia fibroblast cell line 326V (FA-G) 326v Human Fanconi anaemia fibroblast cell line 326V (FA-G) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Oncogene (0950-9232) 2008 Only protein-protein interactions imex curation wilson-2008-8 FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. human-eufa143 Homo sapiens Fanconi anaemia lymphoblast cell line EUFA143 (FA-G) eufa143 Human Fanconi anaemia lymphoblast cell line EUFA143 (FA-G) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Oncogene (0950-9232) 2008 Only protein-protein interactions imex curation wilson-2008-9 FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. crigr-nm3 Cricetulus griseus - CHO derived cell line NM3 harbouring a mutation in FANCG nm3 Chinese hamster ovary cell derived cell line NM3 harbouring mutated FANCG This is a FA-like cell line anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Oncogene (0950-9232) 2008 Only protein-protein interactions imex curation wilson-2008-13 FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. crigr-aa8 Cricetulus griseus AA8 cell line (derived from CHO-K1) aa8 Chinese hamster cell line (derived from CHO-K1) This line is a derivative of the CHO-K1 cell line. The AA8 line has 21 chromosomes and is heterozygous at the aprt locus. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Oncogene (0950-9232) 2008 Only protein-protein interactions imex curation wilson-2008-14 FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. crigr-v79 Cricetulus griseus lung fibroblast V79 cell line v79 Chinese hamster lung fibroblast V79 cell line anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Oncogene (0950-9232) 2008 Only protein-protein interactions imex curation wilson-2008-16 FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. human-bd180 Homo sapiens BD180 cell line bd180 Human cell line BD180 anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wilson JB., Yamamoto K., Marriott AS., Hussain S., Sung P., Hoatlin ME., Mathew CG., Takata M., Thompson LH., Kupfer GM., Jones NJ. Cancer - Interactions investigated in the context of cancer Cell lines were treated with 50 nM mitomycin C for 18 h prior to preparation of lysates njjones@liv.ac.uk Oncogene (0950-9232) 2008 Only protein-protein interactions imex curation facd2_human Fanconi anemia group D2 protein FANCD2 FACD protein protein human Homo sapiens Human MVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHPSYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIVSQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVMDKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQTKKYIDRVLRNKIRSGCIQEQLLQSTFSVHYLVLKDMCSSILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAEVDTALDVLLELVVLNPSAMMMNAVFVKGILDYLDNISPQQIRKLFYVLSTLAFSKQNEASSHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAADRSESPSLTQERANLSDEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQHEKLDPKALEWVGHTICNDFQDAFVVDSCVVPEGDFPFPVKALYGLEEYDTQDGIAINLLPLLFSQDFAKDGGPVTSQESGQKLVSPLCLAPYFRLLRLCVERQHNGNLEEIDGLLDCPIFLTDLEPGEKLESMSAKERSFMCSLIFLTLNWFREIVNAFCQETSPEMKGKVLTRLKHIVELQIILEKYLAVTPDYVPPLGNFDVETLDITPHTVTAISAKIRKKGKIERKQKTDGSKTSSSDTLSEEKNSECDPTPSHRGQLNKEFTGKEEKTSLLLHNSHAFFRELDIEVFSILHCGLVTKFILDTEMHTEATEVVQLGPPELLFLLEDLSQKLESMLTPPIARRVPFLKNKGSRNIGFSHLQQRSAQEIVHCVFQLLTPMCNHLENIHNYFQCLAAENHGVVDGPGVKVQEYHIMSSCYQRLLQIFHGLFAWSGFSQPENQNLLYSALHVLSSRLKQGEHSQPLEELLSQSVHYLQNFHQSIPSFQCALYLIRLLMVILEKSTASAQNKEKIASLARQFLCRVWPSGDKEKSNISNDQLHALLCIYLEHTESILKAIEEIAGVGVPELINSPKDASSSTFPTLTRHTFVVFFRVMMAELEKTVKKIEPGTAADSQQIHEEKLLYWNMAVRDFSILINLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKAMLTLNNCREAFWLGNLKNRDLQGEEIKSQNSQESTADESEDDMSSQASKSKATEDGEEDEVSAGEKEQDSDESYDDSD brca2_human Breast cancer type 2 susceptibility protein BRCA2 FANCD1 FACD Fanconi anemia group D1 protein protein protein human Homo sapiens Human MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPNLFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTVKTKMDQADDVSCPLLNSCLSESPVVLQCTHVTPQRDKSVVCGSLFHTPKFVKGRQTPKHISESLGAEVDPDMSWSSSLATPPTLSSTVLIVRNEEASETVFPHDTTANVKSYFSNHDESLKKNDRFIASVTDSENTNQREAASHGFGKTSGNSFKVNSCKDHIGKSMPNVLEDEVYETVVDTSEEDSFSLCFSKCRTKNLQKVRTSKTRKKIFHEANADECEKSKNQVKEKYSFVSEVEPNDTDPLDSNVANQKPFESGSDKISKEVVPSLACEWSQLTLSGLNGAQMEKIPLLHISSCDQNISEKDLLDTENKRKKDFLTSENSLPRISSLPKSEKPLNEETVVNKRDEEQHLESHTDCILAVKQAISGTSPVASSFQGIKKSIFRIRESPKETFNASFSGHMTDPNFKKETEASESGLEIHTVCSQKEDSLCPNLIDNGSWPATTTQNSVALKNAGLISTLKKKTNKFIYAIHDETSYKGKKIPKDQKSELINCSAQFEANAFEAPLTFANADSGLLHSSVKRSCSQNDSEEPTLSLTSSFGTILRKCSRNETCSNNTVISQDLDYKEAKCNKEKLQLFITPEADSLSCLQEGQCENDPKSKKVSDIKEEVLAAACHPVQHSKVEYSDTDFQSQKSLLYDHENASTLILTPTSKDVLSNLVMISRGKESYKMSDKLKGNNYESDVELTKNIPMEKNQDVCALNENYKNVELLPPEKYMRVASPSRKVQFNQNTNLRVIQKNQEETTSISKITVNPDSEELFSDNENNFVFQVANERNNLALGNTKELHETDLTCVNEPIFKNSTMVLYGDTGDKQATQVSIKKDLVYVLAEENKNSVKQHIKMTLGQDLKSDISLNIDKIPEKNNDYMNKWAGLLGPISNHSFGGSFRTASNKEIKLSEHNIKKSKMFFKDIEEQYPTSLACVEIVNTLALDNQKKLSKPQSINTVSAHLQSSVVVSDCKNSHITPQMLFSKQDFNSNHNLTPSQKAEITELSTILEESGSQFEFTQFRKPSYILQKSTFEVPENQMTILKTTSEECRDADLHVIMNAPSIGQVDSSKQFEGTVEIKRKFAGLLKNDCNKSASGYLTDENEVGFRGFYSAHGTKLNVSTEALQKAVKLFSDIENISEETSAEVHPISLSSSKCHDSVVSMFKIENHNDKTVSEKNNKCQLILQNNIEMTTGTFVEEITENYKRNTENEDNKYTAASRNSHNLEFDGSDSSKNDTVCIHKDETDLLFTDQHNICLKLSGQFMKEGNTQIKEDLSDLTFLEVAKAQEACHGNTSNKEQLTATKTEQNIKDFETSDTFFQTASGKNISVAKESFNKIVNFFDQKPEELHNFSLNSELHSDIRKNKMDILSYEETDIVKHKILKESVPVGTGNQLVTFQGQPERDEKIKEPTLLGFHTASGKKVKIAKESLDKVKNLFDEKEQGTSEITSFSHQWAKTLKYREACKDLELACETIEITAAPKCKEMQNSLNNDKNLVSIETVVPPKLLSDNLCRQTENLKTSKSIFLKVKVHENVEKETAKSPATCYTNQSPYSVIENSALAFYTSCSRKTSVSQTSLLEAKKWLREGIFDGQPERINTADYVGNYLYENNSNSTIAENDKNHLSEKQDTYLSNSSMSNSYSYHSDEVYNDSGYLSKNKLDSGIEPVLKNVEDQKNTSFSKVISNVKDANAYPQTVNEDICVEELVTSSSPCKNKNAAIKLSISNSNNFEVGPPAFRIASGKIVCVSHETIKKVKDIFTDSFSKVIKENNENKSKICQTKIMAGCYEALDDSEDILHNSLDNDECSTHSHKVFADIQSEEILQHNQNMSGLEKVSKISPCDVSLETSDICKCSIGKLHKSVSSANTCGIFSTASGKSVQVSDASLQNARQVFSEIEDSTKQVFSKVLFKSNEHSDQLTREENTAIRTPEHLISQKGFSYNVVNSSAFSGFSTASGKQVSILESSLHKVKGVLEEFDLIRTEHSLHYSPTSRQNVSKILPRVDKRNPEHCVNSEMEKTCSKEFKLSNNLNVEGGSSENNHSIKVSPYLSQFQQDKQQLVLGTKVSLVENIHVLGKEQASPKNVKMEIGKTETFSDVPVKTNIEVCSTYSKDSENYFETEAVEIAKAFMEDDELTDSKLPSHATHSLFTCPENEEMVLSNSRIGKRRGEPLILVGEPSIKRNLLNEFDRIIENQEKSLKASKSTPDGTIKDRRLFMHHVSLEPITCVPFRTTKERQEIQNPNFTAPGQEFLSKSHLYEHLTLEKSSSNLAVSGHPFYQVSATRNEKMRHLITTGRPTKVFVPPFKTKSHFHRVEQCVRNINLEENRQKQNIDGHGSDDSKNKINDNEIHQFNKNNSNQAAAVTFTKCEEEPLDLITSLQNARDIQDMRIKKKQRQRVFPQPGSLYLAKTSTLPRISLKAAVGGQVPSACSHKQLYTYGVSKHCIKINSKNAESFQFHTEDYFGKESLWTGKGIQLADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISRIWVYNHYRWIIWKLAAMECAFPKEFANRCLSPERVLLQLKYRYDTEIDRSRRSAIKKIMERDDTAAKTLVLCVSDIISLSANISETSSNKTSSADTQKVAIIELTDGWYAVKAQLDPPLLAVLKNGRLTVGQKIILHGAELVGSPDACTPLEAPESLMLKISANSTRPARWYTKLGFFPDPRPFPLPLSSLFSDGGNVGCVDVIIQRAYPIQWMEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENTTKPYLPSRALTRQQVRALQDGAELYEAVKNAADPAYLEGYFSEEQLRALNNHRQMLNDKKQAQIQLEIRKAMESAEQKEQGLSRDVTTVWKLRIVSYSKKEKDSVILSIWRPSSDLYSLLTEGKRYRIYHLATSKSKSKSERANIQLAATKKTQYQQLPVSDEILFQIYQPREPLHFSKFLDPDFQPSCSEVDLIGFVVSVVKKTGLAPFVYLSDECYNLLAIKFWIDLNEDIIKPHMLIAASNLQWRPESKSGLLTLFAGDFSVFSASPKEGHFQETFNKMKNTVENIDILCNEAENKLMHILHANDPKWSTPTKDCTSGPYTAQIIPGTGNKLLMSSPNCEIYYQSPLSLCMAKRKSVSTPVSAQMTSKSCKGEKEIDDQKNCKKRRALDFLSRLPLPPPVSPICTFVSPAAQKAFQPPRSCGTKYETPIKKKELNSPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEKQFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI q9bxw9-2 Fanconi anemia group D2 protein FANCD2 FACD protein protein human Homo sapiens Human MVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHPSYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIVSQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVMDKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQTKKYIDRVLRNKIRSGCIQEQLLQSTFSVHYLVLKDMCSSILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAEVDTALDVLLELVVLNPSAMMMNAVFVKGILDYLDNISPQQIRKLFYVLSTLAFSKQNEASSHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAADRSESPSLTQERANLSDEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQHEKLDPKALEWVGHTICNDFQDAFVVDSCVVPEGDFPFPVKALYGLEEYDTQDGIAINLLPLLFSQDFAKDGGPVTSQESGQKLVSPLCLAPYFRLLRLCVERQHNGNLEEIDGLLDCPIFLTDLEPGEKLESMSAKERSFMCSLIFLTLNWFREIVNAFCQETSPEMKGKVLTRLKHIVELQIILEKYLAVTPDYVPPLGNFDVETLDITPHTVTAISAKIRKKGKIERKQKTDGSKTSSSDTLSEEKNSECDPTPSHRGQLNKEFTGKEEKTSLLLHNSHAFFRELDIEVFSILHCGLVTKFILDTEMHTEATEVVQLGPPELLFLLEDLSQKLESMLTPPIARRVPFLKNKGSRNIGFSHLQQRSAQEIVHCVFQLLTPMCNHLENIHNYFQCLAAENHGVVDGPGVKVQEYHIMSSCYQRLLQIFHGLFAWSGFSQPENQNLLYSALHVLSSRLKQGEHSQPLEELLSQSVHYLQNFHQSIPSFQCALYLIRLLMVILEKSTASAQNKEKIASLARQFLCRVWPSGDKEKSNISNDQLHALLCIYLEHTESILKAIEEIAGVGVPELINSPKDASSSTFPTLTRHTFVVFFRVMMAELEKTVKKIEPGTAADSQQIHEEKLLYWNMAVRDFSILINLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKAMLTLNNCREAFWLGNLKNRDLQGEEIKSQNSQESTADESEDDMSSQASKSKATEDGEEDEVSAGEKEQDSDESYDDSD Contains a phosphoserine at position 1423. Contains a phosphothreonine at position 1426. Contains a phosphoserine at position 1435. g3gx36_crigr I79_002348 protein protein crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster MLLIIYSTSTQTKKGSEKVLRNKIQSGCIQEQLLEGTFSTHYMVLKDICPSILLLAQTLFHSQDQRIILFGSLLYKYAFKFFDTYCQQEVVGALVTHVCSGNEAEVDTALDVLLELIALNPSAMRLNAVFVKGILDYLETMSPQQIRKIFCILSTLAFSQQPGTSNHIQDEMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAEDRSVPSNSTQRRADLSSEWCTQVTSLLQLVHSCTEHSPWASSLYYDEFANLIQERKLAPKTLEWVGQTIFNDFQDAFVVDFCAIPEGDFPFPVKALYGLEESSTQDGIVINLLPLFFQEFAGVSQMTSQESSQKSMSSLCLASHFRLLRLCVARQHNGNLDEIDGLLDCPLFLPDLEPGEKLESMSAKERSLMCSLTFLTFNWFREVVNAFCQQTSPEMKGKVLSRLKDLVELQEILEKYLAVIPDYVPPFANVDMDTLDMIPKSSSAVSTKNRNKGKMGGRKQKADISKASSTETLLTEDTSECDTVTSGRSPVEKESAGKEGKTFVSLQNYHAFFRELDIEVFSILHSGLVTKFILDTEMHTEATEVVQLGPAELLFLLEDLSQKLENVLTPSFAKRLCFLKNKGNRNIGFSHLHQRSVQDIVHCVVQLLTPMCNHLENIHNYFQSLGAEHLSVDDKPRVKAQEQHTMSSCYQKLLQIFYTLFAWKGFTHHSNLHLLHSALEVLTSRLKQTEQEQPLEELISQSFNYLQNFHHCIPNFQCGLYLLRLLMTLLEKSAAPTQKKEKLATLAKQLLCRAWPHGEKEKNTNFNDHLHDLLCIYLEHTDNVLKAIEEIAGVGVPELVNAPKDASSSTFPMLTRHTFVIFFRVMMAELEKTVKSLQAGTATDSQQVHEEKLLYWNMAVRDFSILINLMKVFDSYPVLHVCLKYGRHFVEAFLKQCMPLLDFCFRKHREDVLSLLETLQRNTRLLHHLCGHSKIHQDTRLTKHVPLLKKSLELLVCRVKAMLVLNNCREAFWLGTLKNRDLQGEEIVSQHLSSPESTSEDSESGMTSHVSRDRATQDGEDEASDGQKDQDNDESDDSSD q8r4x4_crigr BRCA2 protein protein crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster KNCSHIQPWETDCLSCLPERQCEYDPKGPKVSDGKEEVLVSACHPAGQHTAAAQPSSISFELQEDPVNGHNSTSPKETPSLKVLLSKPVVLSRGKVSCKMPEKLQCESYKDNTELSKSIPLGGNKIHILSENSKPPELLPPGKYVTEASPTVKSQFNQNTNLAVKKNDQEETPFISEVTVNVSSGELFPDNENNFAFQVTHENNKTALGSTVELQEEDLRHAKGPNLNNSPTAVDGDIGDEQAAHALIMEDSDSSALVHECAKKSRNTIEQHLKGTTDKDFNSSLDVKSDGNNDYTDKWPGFLDPVFKHKFGGSFRTASNKEIKLSEHNVKKSKMFFKDIEEEYPTSLTCIDIVNASPLANQEILSGPYTFDLQSVTTMSAHPQSQASVSCEDTHTSLQVLPSKQDFHSNHNLTPSQKAEITELSTILEESGSQFEFTQFKKPSHVAQNNIPEVPGKQTVAINTTSEGWKRIGLHLTVDPASVAQTDDSKKFEGSAGFRQSFPCLLKSSCNKNTSSFLANVNEMEFRGFRSALGTKLSVSSEALQKAVKLFSDIESGSEETSTKVDPRALSSGARHDSGASVFKIRKQNSGKSFDEKTSKCQVTLQNNTEVTTGIFVDRNPENYARNTKCEDNNSTGFQRSPYKLKNSEDSESSTSGTVSVHQDDGDLPCAADHCSKYPESCSQYVREENTQIKECVSDLTCLEVMKAEETCYIQPSDKEQLPSGKMEQNRKDFNISFQTASGKNVRVSEESLSKSMNILNQVTDESIISSDSLNSKFHCGTNNNKMGISHHKETTSTKKVFEERFPVGTVSQLPTLQQHPRCEIESIKEPALLGFHTASGKKVKIMQKSLDKVKNLFDETQYVSHQGSKPLKDRENCKEGLALGCETIEIPASKCEEMQKSFLSKESEVLSKQSDRLYRSTENLRTSNGTSSKANVHGNIESEIEKSPTTCCISHLSYSVTEDSALTCDTGHGRKTCVSESSLSKDRKWLRDRLGDKLQKRDAAEIECVKEHTEGYAGDASCEHSLDSIRNEVDINCVSENQTSALFSDPSMCHSCPSHFGCHCDNKHNDSGYFSKNKIYSDTQPDTKNEDTANFSSVYATKEVNIYPPTVNEDICVQKLETNSSPHTNKNVAIDLAIADSRNCKVCPSKFITDHSQETVKTVKAIFTHNSDKTIKQNTKSKPDTCRTSCQKALDNSEDFICPSSLEDDYMNSHKTSVYTHDEQILQHNLSVSGLEKAQIPPVHLETWDKCKSTRELAQAACSSHMPGIFSTASGKAVQVSDASLEKARQVFSEMDGGAKQLLSTLSLESHEQSDHSGRRENSVTHNPEDVLSLPKTFASNANSSVFSGFSTAGGKRVTVSESALHKVKGMLEEFDLIGTEHTLQCPPTSEGVSKILPQYCVEKRTPEYPINSKLQKTYDDKFSLPNNYKESASLGNTHSLEASPQLSQFKQDTRLVLGTKVSLLEKEQTFPQNIKTESGVMET fancg_human Fanconi anemia group G protein FANCG XRCC9 DNA repair protein XRCC9 protein protein human Homo sapiens Human MSRQTTSVGSSCLDLWREKNDRLVRQAKVAQNSGLTLRRQQLAQDALEGLRGLLHSLQGLPAAVPVLPLELTVTCNFIILRASLAQGFTEDQAQDIQRSLERVLETQEQQGPRLEQGLRELWDSVLRASCLLPELLSALHRLVGLQAALWLSADRLGDLALLLETLNGSQSGASKDLLLLLKTWSPPAEELDAPLTLQDAQGLKDVLLTAFAYRQGLQELITGNPDKALSSLHEAASGLCPRPVLVQVYTALGSCHRKMGNPQRALLYLVAALKEGSAWGPPLLEASRLYQQLGDTTAELESLELLVEALNVPCSSKAPQFLIEVELLLPPPDLASPLHCGTQSQTKHILASRCLQTGRAGDAAEHYLDLLALLLDSSEPRFSPPPSPPGPCMPEVFLEAAVALIQAGRAQDALTLCEELLSRTSSLLPKMSRLWEDARKGTKELPYCPLWVSATHLLQGQAWVQLGAQKVAISEFSRCLELLFRATPEEKEQGAAFNCEQGCKSDAALQQLRAAALISRGLEWVASGQDTKALQDFLLSVQMCPGNRDTYFHLLQTLKRLDRRDEATALWWRLEAQTKGSHEDALWSLPLYLESYLSWIRPSDRDAFLEEFRTSLPKSCDL fancd2-brca2-4 FANCD2 coimmunoprecipitates BRCA2 in BD220 (FA-A) lysates 726999 N/A 727014 unspecified role unspecified role bait bait N/A 727015 unspecified role unspecified role prey prey physical association physical association false false false 1 A fancd2-brca2-15 FANCD2-S coimmunoprecipitates with BRCA2 in BD220 (FA-A) lysates 726999 N/A 727015 unspecified role unspecified role bait bait N/A 727014 unspecified role unspecified role prey prey physical association physical association false false false 2 C Only the FANCD2-S isoform coimmunoprecipitates with BRCA2 in this FA-A cell line. fancd2-brca2-5 FANCD2 coimmunoprecipitates BRCA2 in BD215 (FA-C) lysates 727000 N/A 727014 unspecified role unspecified role bait bait N/A 727015 unspecified role unspecified role prey prey physical association physical association false false false 1 A fancd2-brca2-17 FANCD2 coimmunoprecipitates with BRCA2 in BD215 (FA-C) lysates 727000 N/A 727015 unspecified role unspecified role bait bait N/A 727014 unspecified role unspecified role prey prey physical association physical association false false false 2 C fancd2-brca2-6 FANCD2 coimmunoprecipitates BRCA2 in EUFA409 (FA-E) lysates 727001 N/A 727015 unspecified role unspecified role prey prey N/A 727014 unspecified role unspecified role bait bait physical association physical association false false false 1 A fancd2-brca2-18 FANCD2 coimmunoprecipitates with BRCA2 in EUFA409 (FA-E) lysates 727001 N/A 727014 unspecified role unspecified role prey prey N/A 727015 unspecified role unspecified role bait bait physical association physical association false false false 2 C Only the FANCD2-S isoform coimmunoprecipitated with BRCA2 in the FA-E cell line. fancd2-brca2-7 FANCD2 coimmunoprecipitates BRCA2 in EUFA121 (FA-F) lysates 727002 N/A 727015 unspecified role unspecified role prey prey N/A 727014 unspecified role unspecified role bait bait physical association physical association false false false 1 A fancd2-brca2-19 FANCD2 coimmunoprecipitates with BRCA2 in EUFA121 (FA-F) lysates 727002 N/A 727015 unspecified role unspecified role bait bait N/A 727014 unspecified role unspecified role prey prey physical association physical association false false false 2 C Only the FANCD2-S isoform coimmunoprecipitated with BRCA2 in theis FA-F cell line. fancd2-brca2-12 FANCD2 K561R coimmunoprecipitates BRCA2 in PD20 lysates 727003 N/A 727016 unspecified role unspecified role bait bait Q9BXW9-2:p.Lys561Arg mutation mutation certain certain sequence position certain certain certain sequence position certain false N/A 727015 unspecified role unspecified role prey prey physical association physical association false false false 2 B Q9BXW9 transfection fancd2-brca2-13 Exogenous FANCD2 coimmunoprecipitates BRCA2 in PD20 lysates 727003 N/A 727015 unspecified role unspecified role prey prey N/A 727014 unspecified role unspecified role bait bait physical association physical association false false false 2 B This interaction occurred in cells functionally complemented with human chromosome 3p. fancd2-brca2-14 FANCD2 coimmunoprecipitates BRCA2 in HSC72 lysates 727004 N/A 727015 unspecified role unspecified role prey prey N/A 727016 unspecified role unspecified role bait bait physical association physical association false false false 2 B fancd2-brca2-16 FANCD2 coimmunoprecipitates with BRCA2 in HSC72 lysates 727004 N/A 727015 unspecified role unspecified role bait bait N/A 727016 unspecified role unspecified role prey prey physical association physical association false false false 2 C Only the FANCD2-S isoform coimmunoprecipitates with BRCA2 in this FA-A cell line. fancd2-brca2-11 FANCD2 coimmunoprecipitates BRCA2 in 40BP6 lysates 727005 N/A 727017 unspecified role unspecified role bait bait N/A 727018 unspecified role unspecified role prey prey physical association physical association false false false 1 B, 3 A Introduction of wild-type FANCG restored the interaction of FANCD2-BRCA2. brca2-fancd2-2 BRCA2 coimmunoprecipitates FANCD2 in 40BP6 lysates 727005 N/A 727018 unspecified role unspecified role bait bait N/A 727017 unspecified role unspecified role prey prey physical association physical association false false false 2 C The two isoforms of FANCD2, FANCD2-L and FANCD2-S, were co-precipitated with BRCA2. The reintroduction of FANCG restores this interacton. fancd2-brca2 FANCD2 coimmunoprecipitates BRCA2 in HeLa lysates 727006 N/A 727014 unspecified role unspecified role bait bait N/A 727015 unspecified role unspecified role prey prey physical association physical association false false false 1 A, 2B fancd2-brca2-3 FANCD2 coimmunoprecipitates BRCA2 in CRL-1583 lysates 727007 N/A 727014 unspecified role unspecified role bait bait N/A 727015 unspecified role unspecified role prey prey physical association physical association false false false 1 A fancd2-brca2-8 FANCD2 coimmunoprecipitates BRCA2 in 326V lysates 727008 N/A 727019 unspecified role unspecified role ancillary ancillary N/A 727015 unspecified role unspecified role prey prey N/A 727014 unspecified role unspecified role bait bait association association false false false 1 B Introduction of wild-type FANCG restored the interaction of FANCD2-BRCA2. fancd2-brca2-9 FANCD2 coimmunoprecipitates BRCA2 in EUFA143 lysates 727009 N/A 727019 unspecified role unspecified role ancillary ancillary O15287:p.Ser7Ala mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain false N/A 727015 unspecified role unspecified role prey prey N/A 727014 unspecified role unspecified role bait bait association association false false false 1 B, 2 B, 3 B Introduction of wild-type FANCG restored the interaction of FANCD2-BRCA2. fancd2-brca2-10 FANCD2 coimmunoprecipitates BRCA2 in NM3 lysates 727010 N/A 727019 unspecified role unspecified role ancillary ancillary O15287:p.Ser7Ala mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain false N/A 727017 unspecified role unspecified role bait bait N/A 727018 unspecified role unspecified role prey prey association association false false false 1 B, 3 A Introduction of wild-type FANCG restored the interaction of FANCD2-BRCA2. brca2-fancd2-4 BRCA2 coimmunoprecipitates FANCD2 in AA8 lysates 727011 N/A 727017 unspecified role unspecified role prey prey N/A 727018 unspecified role unspecified role bait bait physical association physical association false false false 2 C, 3 A The two isoforms of FANCD2, FANCD2-L and FANCD2-S, were co-precipitated with BRCA2. brca2-fancd2-1 BRCA2 coimmunoprecipitates FANCD2 in V79 lysates 727012 N/A 727017 unspecified role unspecified role prey prey N/A 727018 unspecified role unspecified role bait bait physical association physical association false false false 2 C The two isoforms of FANCD2, FANCD2-L and FANCD2-S, were co-precipitated with BRCA2. fancd2-brca2-20 FANCD2 coimmunoprecipitates BRCA2 in BD180 lysates 727013 N/A 727015 unspecified role unspecified role prey prey N/A 727014 unspecified role unspecified role bait bait physical association physical association false false false 2 B, 3 B