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    <entry>
        <source releaseDate="2006-10-26+01:00">
            <names>
                <shortLabel>IntAct</shortLabel>
                <fullName>European Bioinformatics Institute</fullName>
                <alias typeAc="MI:1041" type="synonym">IntAct</alias>
                <alias typeAc="MI:1041" type="synonym">intact</alias>
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                <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
                <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
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                <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
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                <attribute name="url">http://www.ebi.ac.uk/</attribute>
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        </source>
        <experimentList>
            <experimentDescription id="499028">
                <names>
                    <shortLabel>krones_herz-2006-1</shortLabel>
                    <fullName>Signal-dependent control of gluconeogenic key enzyme genes through coactivator-associated arginine methyltransferase 1.</fullName>
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                <hostOrganismList>
                    <hostOrganism ncbiTaxId="10116">
                        <names>
                            <shortLabel>rat-h4iie</shortLabel>
                            <fullName>Rat hepatoma cell line H4IIE</fullName>
                        </names>
                        <cellType>
                            <names>
                                <shortLabel>h4iie</shortLabel>
                                <fullName>Rat hepatoma cell line H4IIE</fullName>
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                <interactionDetectionMethod>
                    <names>
                        <shortLabel>anti bait coip</shortLabel>
                        <fullName>anti bait coimmunoprecipitation</fullName>
                        <alias typeAc="MI:1041" type="synonym">anti bait coip</alias>
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                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>western blot</shortLabel>
                        <fullName>western blot</fullName>
                        <alias typeAc="MI:0303" type="go synonym">Immuno blot</alias>
                        <alias typeAc="MI:1041" type="synonym">Immuno blot</alias>
                    </names>
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                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
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                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Krones-Herzig A., Mesaros A., Metzger D., Ziegler A., Lemke U., Bruning JC., Herzig S.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">BioCreative - Critical Assessment of Information Extraction systems in Biology</attribute>
                    <attribute name="exp-modification" nameAc="MI:0627">Cells were treated for 1 hour with forskolin (10 micro molar) or untreated.</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">s.herzig@dkfz.de</attribute>
                    <attribute name="journal" nameAc="MI:0885">J. Biol. Chem. (0021-9258)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2006</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="499029">
                <names>
                    <shortLabel>carm1_rat</shortLabel>
                    <fullName>Histone-arginine methyltransferase CARM1</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Protein arginine N-methyltransferase 4</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Coactivator-associated arginine methyltransferase 1</alias>
                    <alias typeAc="MI:0301" type="gene name">Carm1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Prmt4</alias>
                </names>
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                        <shortLabel>rat</shortLabel>
                        <fullName>Rattus norvegicus (Rat)</fullName>
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                <sequence>MAAAAATAVGPGAGSAGVAGPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEVRAGPDAAGIALYSHEDVCVFKCSVSRETECSRVGRQSFIITLGCNSVLIQFATPHDFCSFYNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYTGTTPSPPPGSHYTSPSENMWNTGSTYNLSSGVAVAGMPTAYDLSSVIAGGSSVGHNNLIPLANTGIVNHTHSRMGSIMSTGIVQGNRVAGPWAGDLPPGLRTRSSYQWGPGRLRGHAGSSVPMTCPTGSSGAQGGGGSSSAHYAVNNQFTMGGPAISMASPMSIPTNTMHYGS</sequence>
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                <names>
                    <shortLabel>creb1_rat</shortLabel>
                    <fullName>Cyclic AMP-responsive element-binding protein 1</fullName>
                    <alias typeAc="MI:0301" type="gene name">Creb1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Creb-1</alias>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008542" secondary="visual learning" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0055025" secondary="positive regulation of cardiac muscle tissue development" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007179" secondary="transforming growth factor beta receptor signaling pathway" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046889" secondary="positive regulation of lipid biosynthetic process" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045672" secondary="positive regulation of osteoclast differentiation" version="SP_209"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_006245127.1"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR004827" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990589" secondary="ATF4-CREB1 transcription factor complex" version="SP_209"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-881907" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007409" secondary="axonogenesis" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010944" secondary="negative regulation of transcription by competitive promoter binding" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001666" secondary="response to hypoxia" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006355" secondary="regulation of transcription, DNA-templated" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071560" secondary="cellular response to transforming growth factor beta stimulus" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030544" secondary="Hsp70 protein binding" version="SP_209"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-36407N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001223" secondary="transcription coactivator binding" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033762" secondary="response to glucagon" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990763" secondary="arrestin family protein binding" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007623" secondary="circadian rhythm" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071294" secondary="cellular response to zinc ion" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060428" secondary="lung epithelium development" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071363" secondary="cellular response to growth factor stimulus" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006468" secondary="protein phosphorylation" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007595" secondary="lactation" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035094" secondary="response to nicotine" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006357" secondary="regulation of transcription by RNA polymerase II" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1902065" secondary="response to L-glutamate" version="SP_209"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973322" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1901215" secondary="negative regulation of neuron death" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" secondary="nucleoplasm" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045600" secondary="positive regulation of fat cell differentiation" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034670" secondary="chemotaxis to arachidonic acid" version="SP_209"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_604392.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001228" secondary="DNA-binding transcription activator activity, RNA polymerase II-specific" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048145" secondary="regulation of fibroblast proliferation" version="SP_209"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10116">
                    <names>
                        <shortLabel>rat</shortLabel>
                        <fullName>Rattus norvegicus (Rat)</fullName>
                        <alias typeAc="MI:1041" type="synonym">Rat</alias>
                    </names>
                </organism>
                <sequence>MTMDSGADNQQSGDAAVTEAESQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-14479-1" id="499031">
                <names>
                    <shortLabel>carm1-creb</shortLabel>
                    <fullName>Coimmunoprecipitaion reveals  interaction between CARM1  and CREB</fullName>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-973418" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-14479-1" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0469" refType="imex source"/>
                </xref>
                <experimentList>
                    <experimentRef>499028</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="499032">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-973419" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>499029</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="499033">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-973420" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>499030</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">Figure 4B</attribute>
                    <attribute name="agonist" nameAc="MI:0625">Forskolin</attribute>
                    <attribute name="caution" nameAc="MI:0618">There are four variants of Coactivator-associated arginine methyltransferase 1 protein and the specfic variant recognised by the antibody used for coimmunoprecipitaion is not stated in the text.</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
