IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ girardini-2011-4 A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. human-mda_mb_231 Homo sapiens Caucasian breast adenocarcinoma mda_mb_231 Human Caucasian breast adenocarcinoma ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. Formaldehyde was used for crosslinking. delsal@lncib.it Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation Cancer - Interactions investigated in the context of cancer girardini-2011-2 A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. human-mda_mb_231 Homo sapiens Caucasian breast adenocarcinoma mda_mb_231 Human Caucasian breast adenocarcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. delsal@lncib.it Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation Cancer - Interactions investigated in the context of cancer girardini-2011-1 A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. The p53 mutation R172H has been entered as R169H, using amino acid numbering in the current UniProt version of (mus) p53. The authors state that the TAp63alpha construct is murine in origin. (and has an identity of ~ 97% with TAp63alpha of human origin) GST-Pin1 is stated to be Human, in Zacchi et al., 2002. delsal@lncib.it Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation Cancer - Interactions investigated in the context of cancer girardini-2011-6 A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. mouse-embryonic_fibroblast Mus musculus embryonic fibroblasts embryonic_fibroblast Embryonic fibroblast Fibroblasts taken from an embryonic as opposed to a foetal or adult source. Foetus is defined as the stage at which tissue diferentiation is initiated. Tissue taken from an embryonic as opposed to a foetal or adult source. Embryo is defined as the development stage prior to organ formation. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. delsal@lncib.it Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation Cancer - Interactions investigated in the context of cancer girardini-2011-3 A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. human-mda_mb_231 Homo sapiens Caucasian breast adenocarcinoma mda_mb_231 Human Caucasian breast adenocarcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. delsal@lncib.it Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation Cancer - Interactions investigated in the context of cancer girardini-2011-5 A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. mouse-lymphoma Mus musculus lymphoma Lymphoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. delsal@lncib.it Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation Cancer - Interactions investigated in the context of cancer girardini-2011-9 A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. human-h1299 Homo sapiens lung lymph node carcinoma h1299 Human lung lymph node carcinoma p53 null. These cells have also been reported to secrete the peptide hormone neuromedin B (NMB), but not gastrin releasing peptide (GRP). Also known as NCI H1299 or CRL-5803. http://www.lgcpromochem.com/atcc/ ATCC number: CRL-5803. ATCC number of the cell line is CRL-5803. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. delsal@lncib.it Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation Cancer - Interactions investigated in the context of cancer girardini-2011-10 A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer. human-mda_mb_231 Homo sapiens Caucasian breast adenocarcinoma mda_mb_231 Human Caucasian breast adenocarcinoma anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Girardini J.E., Napoli M., Piazza S., Rustighi A., Marotta C., Radaelli E., Capaci V., Jordan L., Quinlan P., Thompson A., Mano M., Rosato A., Crook T., Scanziani E., Means A.R., Lozano G., Schneider C., Del Sal G. Apoptosis - Interactions involving proteins with a function related to apoptosis The authors have confirmed that the image shown in Fig S2O was made using the cell line MDA-MB-231, not H1299 - as stated on the image. delsal@lncib.it Cancer Cell (1535-6108) 2011 Only protein-protein interactions imex curation Cancer - Interactions investigated in the context of cancer p53_human Cellular tumor antigen p53 TP53 P53 Tumor suppressor p53 Phosphoprotein p53 Antigen NY-CO-13 protein protein human Homo sapiens Human MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD bub1_human_gene Human BUB1 gene gene gene human Homo sapiens Human mis18a_human_gene Human MIS18A gene gene gene human Homo sapiens Human ccne2_human_gene Human CCNE2 gene gene gene human Homo sapiens Human cenpa_human_gene Human CENPA gene gene gene human Homo sapiens Human cpsf6_human_gene Human CPSF6 gene gene gene human Homo sapiens Human dep1a_human_gene DEP domain-containing protein 1A gene gene gene human Homo sapiens Human e41lb_human_gene Human EPB41L4B gene gene gene human Homo sapiens Human fa64a_human_gene Human FAM64A gene gene gene human Homo sapiens Human cnd2_human_gene Human NCAPH gene gene gene human Homo sapiens Human wdr67_human_gene Human WDR67 gene gene gene human Homo sapiens Human pin1_human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Rotamase Pin1 Peptidyl-prolyl cis-trans isomerase Pin1 PIN1 protein protein human Homo sapiens Human MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE q9h3d4-1 Tumor protein 63 TP63 KET P63 P73H P73L TP73L Chronic ulcerative stomatitis protein Keratinocyte transcription factor KET Transformation-related protein 63 Tumor protein p73-like p40 p51 TA*-alpha TAp63alpha P51B protein protein human Homo sapiens Human MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHEFSSPSHLLRTPSSASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE Produced by alternative promoter usage. p63_human Tumor protein 63 TP63 KET P63 P73H P73L TP73L Transformation-related protein 63 Tumor protein p73-like p51 p40 Keratinocyte transcription factor KET Chronic ulcerative stomatitis protein protein protein human Homo sapiens Human MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHEFSSPSHLLRTPSSASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE smad2_human Mothers against decapentaplegic homolog 2 SMAD2 MADH2 MADR2 Mad-related protein 2 SMAD family member 2 JV18-1 protein protein human Homo sapiens Human MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS p53_mouse Cellular tumor antigen p53 Tp53 P53 Trp53 Tumor suppressor p53 protein protein mouse Mus musculus Mouse MTAMEESQSDISLELPLSQETFSGLWKLLPPEDILPSPHCMDDLLLPQDVEEFFEGPSEALRVSGAPAAQDPVTETPGPVAPAPATPWPLSSFVPSQKTYQGNYGFHLGFLQSGTAKSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEGNLYPEYLEDRQTFRHSVVVPYEPPEAGSEYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEVLCPELPPGSAKRALPTCTSASPPQKKKPLDGEYFTLKIRGRKRFEMFRELNEALELKDAHATEESGDSRAHSSYLKTKKGQSTSRHKKTMVKKVGPDSD o88898-1 Tumor protein 63 TA*-alpha TA*p63alpha Tp63 P63 P73l Tp73l Trp63 Transformation-related protein 63 Tumor protein p73-like protein protein mouse Mus musculus Mouse MNFETSRCATLQYCPDPYIQRFIETPAHFSWKESYYRSAMSQSTQTSEFLSPEVFQHIWDFLEQPICSVQPIELNFVDEPSENGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSAKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSMQSQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTMPEGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDSRRNKQQRIKEEGE Produced by alternative promoter usage. pin1_mouse Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Pin1 Peptidyl-prolyl cis-trans isomerase Pin1 protein protein mouse Mus musculus Mouse MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGGSTVGGSSKNGQGEPAKVRCSHLLVKHSQSRRPSSWRQEKITRSKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGPFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE tp53-bub1 1167720 n/a 1167728 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain false n/a 1167729 unspecified role unspecified role prey prey association association false false false 4D, S4G Mutant p53 is specifically recruited on the promoters of all the Pin1/mutant p53 signature genes, whereas on Pin1 depletion its recruitment was reduced by about 2-fold. tp53-mis18a 1167720 n/a 1167730 unspecified role unspecified role prey prey n/a 1167728 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain false association association false false false 4D, S4G Mutant p53 is specifically recruited on the promoters of all the Pin1/mutant p53 signature genes, whereas on Pin1 depletion its recruitment was reduced by about 2-fold. tp53-ccne2 1167720 n/a 1167731 unspecified role unspecified role prey prey n/a 1167728 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain false association association false false false 4D, S4G Mutant p53 is specifically recruited on the promoters of all the Pin1/mutant p53 signature genes, whereas on Pin1 depletion its recruitment was reduced by about 2-fold. tp53-cenpa 1167720 n/a 1167728 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain false n/a 1167732 unspecified role unspecified role prey prey association association false false false 4D, S4G Mutant p53 is specifically recruited on the promoters of all the Pin1/mutant p53 signature genes, whereas on Pin1 depletion its recruitment was reduced by about 2-fold. tp53-cpsf6 1167720 n/a 1167728 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain false n/a 1167733 unspecified role unspecified role prey prey association association false false false 4D, S4G Mutant p53 is specifically recruited on the promoters of all the Pin1/mutant p53 signature genes, whereas on Pin1 depletion its recruitment was reduced by about 2-fold. tp53-dep1a 1167720 n/a 1167734 unspecified role unspecified role prey prey n/a 1167728 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain false association association false false false 4D, S4G Mutant p53 is specifically recruited on the promoters of all the Pin1/mutant p53 signature genes, whereas on Pin1 depletion its recruitment was reduced by about 2-fold. tp53-e41lb 1167720 n/a 1167735 unspecified role unspecified role prey prey n/a 1167728 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain false association association false false false 4D, S4G Mutant p53 is specifically recruited on the promoters of all the Pin1/mutant p53 signature genes, whereas on Pin1 depletion its recruitment was reduced by about 2-fold. tp53-fa64a 1167720 n/a 1167728 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain false n/a 1167736 unspecified role unspecified role prey prey association association false false false 4D, S4G Mutant p53 is specifically recruited on the promoters of all the Pin1/mutant p53 signature genes, whereas on Pin1 depletion its recruitment was reduced by about 2-fold. tp53-cnd2 1167720 n/a 1167737 unspecified role unspecified role prey prey n/a 1167728 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain false association association false false false 4D, S4G Mutant p53 is specifically recruited on the promoters of all the Pin1/mutant p53 signature genes, whereas on Pin1 depletion its recruitment was reduced by about 2-fold. tp53-wdr67 1167720 n/a 1167738 unspecified role unspecified role prey prey n/a 1167728 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain false association association false false false 4D, S4G Mutant p53 is specifically recruited on the promoters of all the Pin1/mutant p53 signature genes, whereas on Pin1 depletion its recruitment was reduced by about 2-fold. pin1-tp53-1 1167720 n/a 1167739 unspecified role unspecified role bait bait n/a 1167731 unspecified role unspecified role prey prey association association false false false 4E, S4H Pin1 is also present on these promoters, but only in a mutant p53 dependent manner. pin1-tp53-2 1167720 n/a 1167730 unspecified role unspecified role prey prey n/a 1167739 unspecified role unspecified role bait bait association association false false false 4E, S4H Pin1 is also present on these promoters, but only in a mutant p53 dependent manner. pin1-tp53-3 1167720 n/a 1167736 unspecified role unspecified role prey prey n/a 1167739 unspecified role unspecified role bait bait association association false false false 4E, S4H Pin1 is also present on these promoters, but only in a mutant p53 dependent manner. pin1-cpsf6 1167720 n/a 1167739 unspecified role unspecified role bait bait n/a 1167733 unspecified role unspecified role prey prey association association false false false 4E, S4H Pin1 is also present on these promoters, but only in a mutant p53 dependent manner. pin1-bub1 1167720 n/a 1167739 unspecified role unspecified role bait bait n/a 1167729 unspecified role unspecified role prey prey association association false false false 4E, S4H Pin1 is also present on these promoters, but only in a mutant p53 dependent manner. pin1-tp53-4 1167720 n/a 1167739 unspecified role unspecified role bait bait n/a 1167738 unspecified role unspecified role prey prey association association false false false 4E, S4H Pin1 is also present on these promoters, but only in a mutant p53 dependent manner. pin1-tp53-5 1167720 n/a 1167739 unspecified role unspecified role bait bait n/a 1167735 unspecified role unspecified role prey prey association association false false false 4E, S4H Pin1 is also present on these promoters, but only in a mutant p53 dependent manner. pin1-tp53-6 1167720 n/a 1167739 unspecified role unspecified role bait bait n/a 1167732 unspecified role unspecified role prey prey association association false false false 4E, S4H Pin1 is also present on these promoters, but only in a mutant p53 dependent manner. pin1-tp53-7 1167720 n/a 1167739 unspecified role unspecified role bait bait n/a 1167737 unspecified role unspecified role prey prey association association false false false 4E, S4H Pin1 is also present on these promoters, but only in a mutant p53 dependent manner. pin1-tp53-8 1167720 n/a 1167739 unspecified role unspecified role bait bait n/a 1167734 unspecified role unspecified role prey prey association association false false false 4E, S4H Pin1 is also present on these promoters, but only in a mutant p53 dependent manner. pin1-tp53-13 1167721 n/a 1167739 unspecified role unspecified role bait bait n/a 1167728 unspecified role unspecified role prey prey P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false S2C lambda phosphatase tp53-pin1-2 1167721 n/a 1167739 unspecified role unspecified role prey prey n/a 1167728 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false S2C lambda phosphatase tap63-pin1 1167721 n/a 1167740 unspecified role unspecified role bait bait n/a 1167739 unspecified role unspecified role prey prey physical association physical association false false false S3D lambda phosphatase tp63-tp53 1167721 n/a 1167741 unspecified role unspecified role bait bait n/a 1167728 unspecified role unspecified role prey prey P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false 3A PIN1 tp63-smad2 1167721 n/a 1167742 unspecified role unspecified role prey prey n/a 1167741 unspecified role unspecified role bait bait physical association physical association false false false S3A shRNA PIN1 pin1-tp53 1167722 n/a 1167739 unspecified role unspecified role bait bait region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1167743 unspecified role unspecified role prey prey P02340:p.Arg172His mutation mutation certain certain sequence position certain certain certain sequence position certain false mouse-embryonic_fibroblast Mus musculus embryonic fibroblasts embryonic_fibroblast Embryonic fibroblast Fibroblasts taken from an embryonic as opposed to a foetal or adult source. Foetus is defined as the stage at which tissue diferentiation is initiated. Tissue taken from an embryonic as opposed to a foetal or adult source. Embryo is defined as the development stage prior to organ formation. physical association physical association false false false 1E (RHS) H-RasV12 pin1-tp53-11 1167722 n/a 1167728 unspecified role unspecified role prey prey P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain false human-mda_mb_231 Homo sapiens Caucasian breast adenocarcinoma mda_mb_231 Human Caucasian breast adenocarcinoma n/a 1167739 unspecified role unspecified role bait bait region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false S2B doxorubicin pin1-tp53-12 1167722 n/a 1167739 unspecified role unspecified role bait bait region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1167728 unspecified role unspecified role prey prey P04637:p.Arg175His mutation mutation certain certain sequence position certain certain certain sequence position certain false human-skbr3 Homo sapiens SKBR3 skbr3 SKBR3 Species: human; Tissue: breast; Tumor: adenocarcinoma; Derived from: metastatic site: pleural effusion physical association physical association false false false S2B doxorubicin pin1-tp63-2 1167722 n/a 1167744 unspecified role unspecified role prey prey human-h1299 Homo sapiens lung lymph node carcinoma h1299 Human lung lymph node carcinoma p53 null. These cells have also been reported to secrete the peptide hormone neuromedin B (NMB), but not gastrin releasing peptide (GRP). Also known as NCI H1299 or CRL-5803. http://www.lgcpromochem.com/atcc/ ATCC number: CRL-5803. ATCC number of the cell line is CRL-5803. n/a 1167739 unspecified role unspecified role bait bait region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ww_domain sufficient to bind sufficient binding region sufficient to bind range range range range false physical association physical association false false false S3D (lower panel) lambda phophatase tp53-pin1-1 1167723 n/a 1167745 unspecified role unspecified role prey prey n/a 1167743 unspecified role unspecified role bait bait P02340:p.Arg172His mutation mutation certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false S1E H-RasV12 pin1-tp53-9 1167723 n/a 1167743 unspecified role unspecified role prey prey P02340:p.Arg172His mutation mutation certain certain sequence position certain certain certain sequence position certain false n/a 1167745 unspecified role unspecified role bait bait physical association physical association false false false S1E H-RasV12 tp63-tp53-1 1167724 n/a 1167728 unspecified role unspecified role prey prey P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain false P04637:p.[Ser33Ala;Ser46Ala;Thr81Ala;Ser315Ala] mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1167741 unspecified role unspecified role bait bait physical association physical association false false false 3B tp53-pin1 1167725 n/a 1167745 unspecified role unspecified role prey prey n/a 1167743 unspecified role unspecified role bait bait P02340:p.Arg172His mutation mutation certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false S1C H-RasV12 tp53-pin1-3 1167726 n/a 1167728 unspecified role unspecified role bait bait P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain false n/a 1167739 unspecified role unspecified role prey prey physical association physical association false false false S2E H-RasV12 tp53-pin1-4 1167727 n/a 1167739 unspecified role unspecified role prey prey n/a 1167728 unspecified role unspecified role bait bait P04637:p.[Ser33Ala;Ser46Ala;Thr81Ala;Ser315Ala] mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false P04637:p.[Ser33Ala;Thr81Ala;Ser315Ala] mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false P04637:p.Arg280Lys mutation mutation certain certain sequence position certain certain certain sequence position certain false region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false P04637:p.[Ser33Ala;Ser46Ala;Thr81Ala] mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false S2O doxorubicin