UniProt UniProt http://www.uniprot.org grimm-2011-2 A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression. human-hep_g2 Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt). hep_g2 human hepatocellular carcinoma (HCC) cells (p53-wt). anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Grimm A.A., Brace C.S., Wang T., Stormo G.D., Imai S. Apoptosis - Interactions involving proteins with a function related to apoptosis Species origin of Sirt1 and HNF1alpha constructs confirmed by the authors (e-mail) imaishin@wustl.edu Aging Cell (1474-9718) 2011 mimix curation grimm-2011-1 A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression. in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Grimm A.A., Brace C.S., Wang T., Stormo G.D., Imai S. Apoptosis - Interactions involving proteins with a function related to apoptosis Species origin of Sirt1 and HNF1alpha constructs confirmed by the authors (e-mail) imaishin@wustl.edu Aging Cell (1474-9718) 2011 mimix curation grimm-2011-3 A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression. mouse-liver Mus musculus liver liver anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Grimm A.A., Brace C.S., Wang T., Stormo G.D., Imai S. Apoptosis - Interactions involving proteins with a function related to apoptosis Species origin of Sirt1 and HNF1alpha constructs confirmed by the authors (e-mail) imaishin@wustl.edu Aging Cell (1474-9718) 2011 mimix curation grimm-2011-4 A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression. human-hep_g2 Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt). hep_g2 human hepatocellular carcinoma (HCC) cells (p53-wt). anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Grimm A.A., Brace C.S., Wang T., Stormo G.D., Imai S. Apoptosis - Interactions involving proteins with a function related to apoptosis Species origin of Sirt1 and HNF1alpha constructs confirmed by the authors (e-mail) imaishin@wustl.edu Aging Cell (1474-9718) 2011 mimix curation sir1_mouse NAD-dependent protein deacetylase sirtuin-1 NAD-dependent protein deacylase sirtuin-1 Sirt1 Sir2l1 SIR2alpha SIR2-like protein 1 Regulatory protein SIR2 homolog 1 protein protein mouse Mus musculus Mouse MADEVALALQAAGSPSAAAAMEAASQPADEPLRKRPRRDGPGLGRSPGEPSAAVAPAAAGCEAASAAAPAALWREAAGAAASAEREAPATAVAGDGDNGSGLRREPRAADDFDDDEGEEEDEAAAAAAAAAIGYRDNLLLTDGLLTNGFHSCESDDDDRTSHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRILQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRPQKELVHLSELPPTPLHISEDSSSPERTVPQDSSVIATLVDQATNNNVNDLEVSESSCVEEKPQEVQTSRNVENINVENPDFKAVGSSTADKNERTSVAETVRKCWPNRLAKEQISKRLEGNQYLFVPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPLEDESEIEEFYNGLEDDTERPECAGGSGFGADGGDQEVVNEAIATRQELTDVNYPSDKS hnf1a_mouse Hepatocyte nuclear factor 1-alpha Hnf1a Hnf-1 Hnf-1a Tcf1 Liver-specific transcription factor LF-B1 Transcription factor 1 protein protein mouse Mus musculus Mouse MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLMVGEGPLDKGESCGGSRGDLTELPNGLGETRGSEDDTDDDGEDFAPPILKELENLSPEEAAHQKAVVESLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYNGPPPGPGPGPALPAHSSPGLPTTTLSPSKVHGVRYGQSATSEAAEVPSSSGGPLVTVSAALHQVSPTGLEPSSLLSTEAKLVSATGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVAQSPFMATMAQLQSPHALYSHKPEVAQYTHTSLLPQTMLITDTNLSTLASLTPTKQVFTSDTEASSEPGLHEPPSPATTIHIPSQDPSNIQHLQPAHRLSTSPTVSSSSLVLYQSSDSNGHSHLLPSNHSVIETFISTQMASSSQ sirt1-hnf1a 1241697 n/a 1241701 unspecified role unspecified role bait bait n/a 1241702 unspecified role unspecified role prey prey physical association physical association false false false 2b Low glucose and low serum hnf1a-sirt1-1 1241697 n/a 1241702 unspecified role unspecified role bait bait n/a 1241701 unspecified role unspecified role prey prey physical association physical association false false false 2c, 3a, 3b and 3c Low glucose and low serum cycloheximide hnf1a-sirt1 1241698 n/a 1241702 unspecified role unspecified role bait bait n/a 1241701 unspecified role unspecified role prey prey direct interaction direct interaction false false false 2A sirt1-hnf1a-1 1241699 n/a 1241701 unspecified role unspecified role bait bait n/a 1241702 unspecified role unspecified role prey prey physical association physical association false false false 2d hnf1a-sirt1-2 1241700 n/a 1241702 unspecified role unspecified role bait bait n/a 1241701 unspecified role unspecified role prey prey physical association physical association false false false S1