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    <entry>
        <source releaseDate="2004-04-01+01:00">
            <names>
                <shortLabel>IntAct</shortLabel>
                <fullName>European Bioinformatics Institute</fullName>
                <alias typeAc="MI:1041" type="synonym">IntAct</alias>
                <alias typeAc="MI:1041" type="synonym">intact</alias>
            </names>
            <bibref>
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            </bibref>
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            <attributeList>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
                <attribute name="search-url" nameAc="MI:0615">http://www.ebi.ac.uk/intact/query/${ac}</attribute>
                <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
                <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
                <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
                <attribute name="url">http://www.ebi.ac.uk/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="102762">
                <names>
                    <shortLabel>xu-2002-1</shortLabel>
                    <fullName>The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein.</fullName>
                </names>
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                    <hostOrganism ncbiTaxId="9606">
                        <names>
                            <shortLabel>human-293</shortLabel>
                            <fullName>Homo sapiens transformed primary embryonal kidney cells</fullName>
                            <alias typeAc="MI:1041" type="synonym">Human</alias>
                        </names>
                        <cellType>
                            <names>
                                <shortLabel>293</shortLabel>
                                <fullName>Transformed human primary embryonal kidney cells.</fullName>
                            </names>
                            <xref>
                                <primaryRef db="mint" dbAc="MI:0471" id="MINT-1782570" refType="identity" refTypeAc="MI:0356"/>
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                            </xref>
                            <attributeList>
                                <attribute name="comment" nameAc="MI:0612">The Cell type named 293 is synonymous with HEK-293.</attribute>
                            </attributeList>
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                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>coip</shortLabel>
                        <fullName>coimmunoprecipitation</fullName>
                        <alias typeAc="MI:0303" type="go synonym">co-immunoprecipitation</alias>
                        <alias typeAc="MI:0303" type="go synonym">CoIp</alias>
                        <alias typeAc="MI:0303" type="go synonym">immunoprecipitation</alias>
                        <alias typeAc="MI:0303" type="go synonym">Co-IP</alias>
                        <alias typeAc="MI:1041" type="synonym">co-immunoprecipitation</alias>
                        <alias typeAc="MI:1041" type="synonym">CoIp</alias>
                        <alias typeAc="MI:1041" type="synonym">immunoprecipitation</alias>
                        <alias typeAc="MI:1041" type="synonym">Co-IP</alias>
                        <alias typeAc="MI:1041" type="synonym">coip</alias>
                    </names>
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                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>western blot</shortLabel>
                        <fullName>western blot</fullName>
                        <alias typeAc="MI:0303" type="go synonym">Immuno blot</alias>
                        <alias typeAc="MI:1041" type="synonym">Immuno blot</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
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                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Xu X., Shi YC., Gao W., Mao G., Zhao G., Agrawal S., Chisolm GM., Sui D., Cui MZ.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">Synapse - Interactions of proteins with an established role in the presynapse.</attribute>
                    <attribute name="journal" nameAc="MI:0885">J. Biol. Chem. (0021-9258)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2002</attribute>
                    <attribute name="dataset" nameAc="MI:0875">Apoptosis - Interactions involving proteins with a function related to apoptosis</attribute>
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            </experimentDescription>
        </experimentList>
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            <interactor id="102763">
                <names>
                    <shortLabel>psn1_human</shortLabel>
                    <fullName>Presenilin-1</fullName>
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                    <alias typeAc="MI:0302" type="gene name synonym">AD3</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">PS1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">PSNL1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Protein S182</alias>
                </names>
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                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_000012.1"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9013700" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042987" secondary="amyloid precursor protein catabolic process" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030326" secondary="embryonic limb morphogenesis" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002038" secondary="positive regulation of L-glutamate import across plasma membrane" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051563" secondary="smooth endoplasmic reticulum calcium ion homeostasis" version="SP_243"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_005267923.1"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6LR4" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005790" secondary="smooth endoplasmic reticulum" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045893" secondary="positive regulation of transcription, DNA-templated" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904646" secondary="cellular response to amyloid-beta" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045296" secondary="cadherin binding" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0098712" secondary="L-glutamate import across plasma membrane" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905908" secondary="positive regulation of amyloid fibril formation" version="SP_243"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2KR6" version="SP_243"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5FN2" version="SP_243"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011535276.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002286" secondary="T cell activation involved in immune response" version="SP_243"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-297277" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001764" secondary="neuron migration" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005789" secondary="endoplasmic reticulum membrane" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035556" secondary="intracellular signal transduction" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042982" secondary="amyloid precursor protein metabolic process" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010629" secondary="negative regulation of gene expression" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" secondary="membrane" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043066" secondary="negative regulation of apoptotic process" version="SP_243"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7C9I" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043198" secondary="dendritic shaft" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007220" secondary="Notch receptor processing" version="SP_243"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-205043" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010468" secondary="regulation of gene expression" version="SP_243"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UIF0" version="SP_92" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051117" secondary="ATPase binding" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090647" secondary="modulation of age-related behavioral decline" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0015871" secondary="choline transport" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048471" secondary="perinuclear region of cytoplasm" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006979" secondary="response to oxidative stress" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045121" secondary="membrane raft" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007611" secondary="learning or memory" version="SP_243"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5A63" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043589" secondary="skin morphogenesis" version="SP_243"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003407" secondary="neural retina development" version="SP_243"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1251985" version="SP_243"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI</sequence>
            </interactor>
            <interactor id="102764">
                <names>
                    <shortLabel>mtch1_human</shortLabel>
                    <fullName>Mitochondrial carrier homolog 1</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Presenilin-associated protein</alias>
                    <alias typeAc="MI:0306" type="orf name">CGI-64</alias>
                    <alias typeAc="MI:0301" type="gene name">MTCH1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">PSAP</alias>
                    <alias typeAc="MI:0306" type="orf name">UNQ1871/PRO4314</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q9NZJ7" version="SP_39" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" secondary="membrane" version="SP_152"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6UX45" version="SP_39" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UJZ5" version="SP_39" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006915" secondary="apoptotic process" version="SP_152"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006919" secondary="activation of cysteine-type endopeptidase activity involved in apoptotic process" version="SP_152"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005739" secondary="mitochondrion" version="SP_152"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043065" secondary="positive regulation of apoptotic process" version="SP_152"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" secondary="integral component of membrane" version="SP_152"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045161" secondary="neuronal ion channel clustering" version="SP_152"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000137409" version="SP_152" refType="gene"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_055156.1"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A8KAX5" version="SP_62" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6PK60" version="SP_39" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9BW23" version="SP_39" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001258570.1"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q7L465" version="SP_39" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9NZR6" version="SP_39" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018108" version="SP_152"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B2RCE3" version="SP_60" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-297455" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="Q9NZJ7" version="SP_152"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000362730" version="SP_152" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005741" secondary="mitochondrial outer membrane" version="SP_152"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009966" secondary="regulation of signal transduction" version="SP_152"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR023395" version="SP_152"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000373627" version="SP_152" refType="transcript"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MGASDPEVAPWARGGAAGMAGAGAGAGARGGAAAGVEARARDPPPAHRAHPRHPRPAAQPSARRMDGGSGGLGSGDNAPTTEALFVALGAGVTALSHPLLYVKLLIQVGHEPMPPTLGTNVLGRKVLYLPSFFTYAKYIVQVDGKIGLFRGLSPRLMSNALSTVTRGSMKKVFPPDEIEQVSNKDDMKTSLKKVVKETSYEMMMQCVSRMLAHPLHVISMRCMVQFVGREAKYSGVLSSIGKIFKEEGLLGFFVGLIPHLLGDVVFLWGCNLLAHFINAYLVDDSVSDTPGGLGNDQNPGSQFSQALAIRSYTKFVMGIAVSMLTYPFLLVGDLMAVNNCGLQAGLPPYSPVFKSWIHCWKYLSVQGQLFRGSSLLFRRVSSGSCFALE</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="102765">
                <names>
                    <shortLabel>q9ujz5-psen1-1</shortLabel>
                    <fullName>Presenilin-1-associated protein interacts with Presenilin-1 and were shown by coimmunoprecipitation to both fractionate to mitochondrion</fullName>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-297467" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005739" secondary="mitochondrion" refType="component" refTypeAc="MI:0354"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005515" secondary="protein binding" refType="function" refTypeAc="MI:0355"/>
                </xref>
                <experimentList>
                    <experimentRef>102762</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="102766">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-297471" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>102763</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="102767">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-297472" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>102764</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
