IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ zatloukal-2014-1 Sensitivity and specificity of in situ proximity ligation for protein interaction analysis in a model of steatohepatitis with Mallory-Denk bodies. mouse-liver Mus musculus liver liver confocal microscopy confocal microscopy immunocytochemistry immunocytochemistry Zatloukal B., Kufferath I., Thueringer A., Landegren U., Zatloukal K., Haybaeck J. Affinomics - Interactions curated for the Affinomics consortium. johannes.haybaeck@medunigraz.at PLoS ONE 2014 Only protein-protein interactions imex curation zatloukal-2014-2 Sensitivity and specificity of in situ proximity ligation for protein interaction analysis in a model of steatohepatitis with Mallory-Denk bodies. mouse-liver Mus musculus liver liver pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Zatloukal B., Kufferath I., Thueringer A., Landegren U., Zatloukal K., Haybaeck J. Affinomics - Interactions curated for the Affinomics consortium. johannes.haybaeck@medunigraz.at PLoS ONE 2014 Only protein-protein interactions imex curation sqstm_mouse Sequestosome-1 Ubiquitin-binding protein p62 STONE14 Sqstm1 A170 STAP protein protein mouse Mus musculus Mouse MASFTVKAYLLGKEEATREIRRFSFCFSPEPEAEAQAAAGPGPCERLLSRVAVLFPTLRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRREHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHREHSKLIFPNPFGHLSDSFSHSRWLRKLKHGHFGWPGWEMGPPGNWSPRPPRAGDGRPCPTAESASAPPEDPNVNFLKNVGESVAAALSPLGIEVDIDVEHGGKRSRLTPTTPESSSTGTEDKSNTQPSSCSSEVSKPDGAGEGPAQSLTEQMKKIALESVGQPEEQMESGNCSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL k2c8_mouse Keratin, type II cytoskeletal 8 Krt8 Krt2-8 Cytokeratin endo A Cytokeratin-8 Keratin-8 Type-II keratin Kb8 protein protein mouse Mus musculus Mouse MSIRVTQKSYKMSTSGPRAFSSRSFTSGPGARISSSSFSRVGSSSSSFRGSMGTGVGLGGFGGAGVGGITAVTVNQSLLSPLKLEVDPNIQAVRTQEKEQIKSLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTSRSNMDNMFESYINNLRRQLEALGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQIHEEEIRELQSQISDTSVVLSMDNSRSLDMDGIIAEVRAQYEDIANRSRAEAETMYQIKYEELQTLAGKHGDDLRRTKTEISEMNRNINRLQAEIEALKGQRASLEAAIADAEQRGEMAIKDAQTKLAELEAALQRAKQDMARQLREYQELMNVKLALDIEITTYRKLLEGEESRLESGMQNMSIHTKTTSGYSGGLSSSYGGLTSPGFSYGMSSFQPGFGSAGGSNTFSRTTKAVVVKKIETRDGKLVSESSDVVSK k1c18_mouse Keratin, type I cytoskeletal 18 Krt18 Kerd Krt1-18 Cytokeratin-18 Keratin-18 Cytokeratin endo B protein protein mouse Mus musculus Mouse MSFTTRSTTFSTNYRSLGSVRTPSQRVRPASSAASVYAGAGGSGSRISVSRSVWGGSVGSAGLAGMGGIQTEKETMQDLNDRLASYLDKVKSLETENRRLESKIREHLEKKGPQGVRDWGHYFKIIEDLRAQIFANSVDNARIVLQIDNARLAADDFRVKYETELAMRQSVESDIHGLRKVVDDTNITRLQLETEIEALKEELLFMKKNHEEEVQGLEAQIASSGLTVEVDAPKSQDLSKIMADIRAQYEALAQKNREELDKYWSQQIEESTTVVTTKSAEIRDAETTLTELRRTLQTLEIDLDSMKNQNINLENSLGDVEARYKAQMEQLNGVLLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRRLLEDGEDFSLNDALDSSNSMQTVQKTTTRKIVDGRVVSETNDTRVLRH mint When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection krt8-sqstm1 1768542 n/a 1768544 unspecified role unspecified role neutral component neutral component n/a 1768545 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 3A, 5C DCC -3,5-diethoxycarbonyl-1,4-dihydrocollidine (CHEBI:83605) After DDC treatment ballooned hepatocytes were present with a disrupted keratin cytoskeleton and MDBs (Mallory-Denk Bodies) involving K8, K18 and p62 were observed. A positive colocalization of p62 and K8 in krt18−/− mice was observed. krt8-sqstm1-1 1768542 n/a 1768546 unspecified role unspecified role neutral component neutral component n/a 1768544 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 3B DCC -3,5-diethoxycarbonyl-1,4-dihydrocollidine (CHEBI:83605) After DDC treatment ballooned hepatocytes were present with a disrupted keratin cytoskeleton and MDBs (Mallory-Denk Bodies) involving K8, K18 and p62 were observed krt8-sqstm1-2 1768543 n/a 1768546 unspecified role unspecified role neutral component neutral component n/a 1768544 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction false false false 4 DCC -3,5-diethoxycarbonyl-1,4-dihydrocollidine (CHEBI:83605) After DDC treatment ballooned hepatocytes were present with a disrupted keratin cytoskeleton and MDBs (Mallory-Denk Bodies) involving K8, K18 and p62 were observed krt8-sqstm1-2 1768543 n/a 1768545 unspecified role unspecified role neutral component neutral component n/a 1768544 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction false false false 4, 6C,7 DCC -3,5-diethoxycarbonyl-1,4-dihydrocollidine (CHEBI:83605) After DDC treatment ballooned hepatocytes were present with a disrupted keratin cytoskeleton and MDBs (Mallory-Denk Bodies) involving K8, K18 and p62 were observed. A positive PLA result was seen in krt18−/− mice.