IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ bonaventura-2014-1 L-DOPA-treatment in primates disrupts the expression of A(2A) adenosine-CB(1) cannabinoid-D(2) dopamine receptor heteromers in the caudate nucleus. macfa-brain_striatum M. fascicularis striatum brain_striatum Brain striatum, Neostratum. pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Bonaventura J., Rico A.J., Moreno E., Sierra S., Sánchez M., Luquin N., Farré D., Müller C.E., Martínez-Pinilla E., Cortés A., Mallol J., Armentero M.T., Pinna A., Canela E.I., Lluís C., McCormick P.J., Lanciego J.L., Casadó V., Franco R. Affinomics - Interactions curated for the Affinomics consortium. Radioligand studies have not been included as the specificities of ligand(s) binding is not known. rfranco123@gmail.com,vcasado@ub.edu Neuropharmacology (0028-3908) 2014 imex curation Only protein-protein interactions f6x9c0_macmu Adenosine receptor A2 ADORA2A protein protein macmu Macaca mulatta (Rhesus macaque) Rhesus macaque MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCNHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSTQESQGNTSLPDVELLSHELKGVCPEPPGLDDPLAQGGAGVS g7p3k6_macfa Cannabinoid receptor 1 EGM_13830 protein protein macfa Macaca fascicularis (Crab-eating macaque) Cynomolgus monkey MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL f7cyh8_macmu D(2) dopamine receptor DRD2 Dopamine D2 receptor protein protein macmu Macaca mulatta (Rhesus macaque) Rhesus macaque MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRSHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKNHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC drd2-g7n3f5 1572173 n/a 1572174 unspecified role unspecified role neutral component neutral component n/a 1572175 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction false false false 1,4,5 The number of positive cells (receptor heteromers) was significantly reduced in Putamen slices compared with the caudate nucleus. The expression of heteromers was reduced in caudate nucleus slices from l-DOPA treated monkeys as compared with control and monkeys with induced Parkinsons Disease. drd2-g7n3f5-1 1572173 n/a 1572176 unspecified role unspecified role neutral component neutral component n/a 1572174 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction false false false 1,4,5 The number of positive cells (receptor heteromers) was significantly reduced in Putamen slices compared with the caudate nucleus. The expression of heteromers was reduced in caudate nucleus slices from l-DOPA treated monkeys as compared with control and monkeys with induced Parkinsons Disease. drd2-g7n3f5-2 1572173 n/a 1572175 unspecified role unspecified role neutral component neutral component n/a 1572176 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction false false false 1,4,5 The number of positive cells (receptor heteromers) was significantly reduced in Putamen slices compared with the caudate nucleus. The expression of heteromers was reduced in caudate nucleus slices from l-DOPA treated monkeys as compared with control and monkeys with induced Parkinsons Disease.