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        <source releaseDate="2014-07-21+01:00">
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                <shortLabel>IntAct</shortLabel>
                <fullName>European Bioinformatics Institute</fullName>
                <alias typeAc="MI:1041" type="synonym">IntAct</alias>
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                <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
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                <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
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                <attribute name="url">http://www.ebi.ac.uk/</attribute>
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            <experimentDescription id="1540770">
                <names>
                    <shortLabel>zhou-2013c-1</shortLabel>
                    <fullName>Resistin reduces mitochondria and induces hepatic steatosis in mice by the protein kinase C/protein kinase G/p65/PPAR gamma coactivator 1 alpha pathway.</fullName>
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                <hostOrganismList>
                    <hostOrganism ncbiTaxId="9606">
                        <names>
                            <shortLabel>human-hep_g2</shortLabel>
                            <fullName>Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).</fullName>
                        </names>
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                                <shortLabel>hep_g2</shortLabel>
                                <fullName>human hepatocellular carcinoma (HCC) cells (p53-wt).</fullName>
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                <interactionDetectionMethod>
                    <names>
                        <shortLabel>pla</shortLabel>
                        <fullName>proximity ligation assay</fullName>
                        <alias typeAc="MI:0303" type="go synonym">pELISA</alias>
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                        <shortLabel>antibody detection</shortLabel>
                        <fullName>identification by antibody</fullName>
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                    <attribute name="author-list" nameAc="MI:0636">Zhou L., Yu X., Meng Q., Li H., Niu C., Jiang Y., Cai Y., Li M., Li Q., An C., Shu L., Chen A., Su H., Tang Y., Yin S., Raschke S., Eckardt K., Eckel J., Yang Z.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">Diabetes - Interactions investigated in the context of Diabetes</attribute>
                    <attribute name="data-processing" nameAc="MI:0633">Identification of proteins was confirmed using Table S2 - primers for RT-PCR.</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">zhoulei@mail.hzau.edu.cn, yangzq@mail.hzau.edu.cn</attribute>
                    <attribute name="journal" nameAc="MI:0885">Hepatology (0270-9139)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2013</attribute>
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                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                    <attribute name="dataset" nameAc="MI:0875">Affinomics - Interactions curated for the Affinomics consortium.</attribute>
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                    <shortLabel>tf65_human</shortLabel>
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                    <alias typeAc="MI:0302" type="gene name synonym">NFKB3</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3</alias>
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                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
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                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS</sequence>
            </interactor>
            <interactor id="1540772">
                <names>
                    <shortLabel>prgc1_human</shortLabel>
                    <fullName>Peroxisome proliferator-activated receptor gamma coactivator 1-alpha</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Ligand effect modulator 6</alias>
                    <alias typeAc="MI:0301" type="gene name">PPARGC1A</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">LEM6</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">PGC1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">PGC1A</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">PPARGC1</alias>
                </names>
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                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q4W5M7" version="SP_110" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019395" secondary="fatty acid oxidation" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071356" secondary="cellular response to tumor necrosis factor" version="SP_197"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6W9L" version="SP_197"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-765486" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071392" secondary="cellular response to estradiol stimulus" version="SP_197"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000513205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003723" secondary="RNA binding" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000785" secondary="chromatin" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043231" secondary="intracellular membrane-bounded organelle" version="SP_197"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000506055"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043025" secondary="neuronal cell body" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045820" secondary="negative regulation of glycolytic process" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006012" secondary="galactose metabolic process" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071354" secondary="cellular response to interleukin-6" version="SP_197"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6K0T" version="SP_197"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6FZP" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0014850" secondary="response to muscle activity" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097440" secondary="apical dendrite" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030900" secondary="forebrain development" version="SP_197"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR012677" version="SP_197"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2151209" version="SP_197"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6IZN" version="SP_197"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="I3RTT9" version="SP_124" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1901558" secondary="response to metformin" version="SP_197"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7E2E" version="SP_197"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001317682.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071456" secondary="cellular response to hypoxia" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030374" secondary="nuclear receptor coactivator activity" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0120162" secondary="positive regulation of cold-induced thermogenesis" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904635" secondary="positive regulation of glomerular visceral epithelial cell apoptotic process" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006397" secondary="mRNA processing" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000791" secondary="euchromatin" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035066" secondary="positive regulation of histone acetylation" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045722" secondary="positive regulation of gluconeogenesis" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0022904" secondary="respiratory electron transport chain" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030331" secondary="estrogen receptor binding" version="SP_197"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001317680.1"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6MS7" version="SP_197"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3CS8" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051552" secondary="flavone metabolic process" version="SP_197"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="Q9UBK2" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003713" secondary="transcription coactivator activity" version="SP_197"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NWK" version="SP_197"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000264867" version="SP_197" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008380" secondary="RNA splicing" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043565" secondary="sequence-specific DNA binding" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000184" secondary="positive regulation of progesterone biosynthetic process" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1901857" secondary="positive regulation of cellular respiration" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035865" secondary="cellular response to potassium ion" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904639" secondary="cellular response to resveratrol" version="SP_197"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="I3RTT6" version="SP_124" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9615017" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048662" secondary="negative regulation of smooth muscle cell proliferation" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0065003" secondary="protein-containing complex assembly" version="SP_197"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3V9V" version="SP_197"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9707616" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0014878" secondary="response to electrical stimulus involved in regulation of muscle adaptation" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042493" secondary="response to drug" version="SP_197"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR034833" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048661" secondary="positive regulation of smooth muscle cell proliferation" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000422" secondary="autophagy of mitochondrion" version="SP_197"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_037393.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000302" secondary="response to reactive oxygen species" version="SP_197"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3D24" version="SP_197"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000109819" version="SP_197" refType="gene"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4QK4" version="SP_197"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000613098"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q3LIG1" version="SP_119" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045893" secondary="positive regulation of transcription, DNA-templated" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007586" secondary="digestion" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042752" secondary="regulation of circadian rhythm" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000272" secondary="negative regulation of signaling receptor activity" version="SP_197"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071332" secondary="cellular response to fructose stimulus" version="SP_197"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3V9T" version="SP_197"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1989781" version="SP_197"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MAWDMCNQDSESVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPSNIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGDVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHANHNHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCTSKKKSHTQSQSQHLQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASPKLKSSCKTVVPPPSKKPRYSESSGTQGNNSTKKGPEQSELYAQLSKSSVLTGGHEERKTKRPSLRLFGDHDYCQSINSKTEILINISQELQDSRQLENKDVSSDWQGQICSSTDSDQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPSQAVFDDEADKTGELRDSDFSNEQFSKLPMFINSGLAMDGLFDDSEDESDKLSYPWDGTQSYSLFNVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEEYQHERLKREEYRREYEKRESERAKQRERQRQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDPASTKSKYDSLDFDSLLKEAQRSLRR</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-22637-1" id="1540773">
                <names>
                    <shortLabel>ppargc1a-rela</shortLabel>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-9545756" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-22637-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>1540770</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="1540774">
                        <names>
                            <shortLabel>n/a</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-9545770" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1540771</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="1540775">
                        <names>
                            <shortLabel>n/a</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-9545769" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1540772</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>proximity</shortLabel>
                        <fullName>proximity</fullName>
                        <alias typeAc="MI:1041" type="synonym">close-contact colocalization</alias>
                        <alias typeAc="MI:1041" type="synonym">neighbourhood interaction</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:2364" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-26564119" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">6</attribute>
                    <attribute name="antagonist" nameAc="MI:0626">KT5823 (a PKG inhibitor)</attribute>
                    <attribute name="agonist" nameAc="MI:0625">Resistin</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
