#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q6NZM9	uniprotkb:Q91XU0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8376575|intact:MINT-4113108|uniprotkb:Q921W3|uniprotkb:Q8BWP6|uniprotkb:Q3TCT7|uniprotkb:Q6PDF0|uniprotkb:Q9EQL3|uniprotkb:Q8BY55|uniprotkb:Q8BUW5|ensembl:ENSMUSP00000021832	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:wrip1_mouse(display_long)|uniprotkb:Wrnip1(gene name)|psi-mi:Wrnip1(display_short)|uniprotkb:Whip(gene name synonym)|uniprotkb:Werner helicase-interacting protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_084491.3|ensembl:ENSMUSG00000021400(gene)|ensembl:ENSMUST00000021832(transcript)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR021886|interpro:IPR027417|interpro:IPR032423|interpro:IPR040539|mint:Q91XU0	-	-	comment:mint|function:Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:3cjtBXbw7X8eJ6V9tsVNsTKXXjA10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P56960	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8316161|ensembl:ENSMUSP00000017408|uniprotkb:B1ARY9|uniprotkb:Q9R0B1|intact:MINT-4094804|uniprotkb:Q9QYS8	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:exosx_mouse(display_long)|uniprotkb:Exosc10(gene name)|psi-mi:Exosc10(display_short)|uniprotkb:Pmscl2(gene name synonym)|uniprotkb:Polymyositis/scleroderma autoantigen 2 homolog(gene name synonym)|uniprotkb:Autoantigen PM/Scl 2 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000017264(gene)|ensembl:ENSMUST00000017408(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000176"("nuclear exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000467"("exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0035327"|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071034"(CUT catabolic process)|go:"GO:0071035"(nuclear polyadenylation-dependent rRNA catabolic process)|go:"GO:0071036"(nuclear polyadenylation-dependent snoRNA catabolic process)|go:"GO:0071037"(nuclear polyadenylation-dependent snRNA catabolic process)|go:"GO:0071038"(nuclear polyadenylation-dependent tRNA catabolic process)|go:"GO:0071039"(nuclear polyadenylation-dependent CUT catabolic process)|go:"GO:0071040"(nuclear polyadenylation-dependent antisense transcript catabolic process)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071048"|go:"GO:0071051"(polyadenylation-dependent snoRNA 3'-end processing)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002562(3'-5' exonuclease)|interpro:IPR010997(HRDC-like)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012588(Exosome-associated factor Rrp6, N-terminal)|interpro:IPR036397|mint:P56960|reactome:R-MMU-6791226|refseq:NP_057908.2	-	-	function:"Part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions. Required for the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA. Could be an exonuclease. Mediates the association of MTR4, C1D and MPP6 wth the exosome and this complex is required for the maturation of 5.8S rRNA. Required for nucleolar localization of C1D"|comment:mint	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:0d5mjwJWcKJp1FOOShsVURcgLYg10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8VEB1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8367081|uniprotkb:O70297|intact:MINT-4096859|uniprotkb:O70292|ensembl:ENSMUSP00000003313	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:grk5_mouse(display_long)|uniprotkb:Grk5(gene name)|psi-mi:Grk5(display_short)|uniprotkb:Gprk5(gene name synonym)|uniprotkb:G protein-coupled receptor kinase GRK5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_061357.3|dip:DIP-46262N|ensembl:ENSMUSG00000003228(gene)|ensembl:ENSMUST00000003313(transcript)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|mint:Q8VEB1|reactome:R-MMU-418555	-	-	comment:mint|function:Specifically phosphorylates the activated forms of G protein-coupled receptors	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:FBTesJYoxSHbBciopXB0VnsS7uc10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8C050	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8391218|intact:MINT-4116279|uniprotkb:Q8CI92|ensembl:ENSMUSP00000042987	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ks6a5_mouse(display_long)|uniprotkb:Rps6ka5(gene name)|psi-mi:Rps6ka5(display_short)|uniprotkb:Msk1(gene name synonym)|uniprotkb:Nuclear mitogen- and stress-activated protein kinase 1(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 5(gene name synonym)|uniprotkb:RSK-like protein kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_705815.1|refseq:NP_001317631.1|ensembl:ENSMUSG00000021180(gene)|ensembl:ENSMUST00000043599(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0043990"(histone H2A-S1 phosphorylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:Q8C050|reactome:R-MMU-198753|reactome:R-MMU-199920|reactome:R-MMU-375165|reactome:R-MMU-5621575|go:"GO:0106310"(protein serine kinase activity)	-	-	comment:mint|function:"Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14)"	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:MIhH01PUvJRSlgDj4ftn2glW5Fw10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O88796	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8459162|intact:MINT-4132955|ensembl:ENSMUSP00000025714	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rpp30_mouse(display_long)|uniprotkb:Rpp30(gene name)|psi-mi:Rpp30(display_short)|uniprotkb:Rnasep2(gene name synonym)|uniprotkb:RNase P subunit 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_062301.3|ensembl:ENSMUSG00000024800(gene)|ensembl:ENSMUST00000025714(transcript)|go:"GO:0000172"(ribonuclease MRP complex)|go:"GO:0001682"(tRNA 5'-leader removal)|go:"GO:0003723"(RNA binding)|go:"GO:0004526"(ribonuclease P activity)|go:"GO:0005655"(nucleolar ribonuclease P complex)|go:"GO:0006364"(rRNA processing)|go:"GO:0008033"(tRNA processing)|go:"GO:0030681"(multimeric ribonuclease P complex)|go:"GO:0033204"(ribonuclease P RNA binding)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR002738(RNase P subunit p30)|interpro:IPR016195(Polymerase and histidinol phosphatase-like)|mint:O88796|reactome:R-MMU-6791226	-	-	comment:mint|function:Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:qANO2qyNO6bx6Sj3ieBH17GUxZ810090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99J85	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8311244|intact:MINT-4104086	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nptxr_mouse(display_long)|uniprotkb:Nptxr(gene name)|psi-mi:Nptxr(display_short)|uniprotkb:Npr(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0008029"(pentraxin receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099150"(regulation of postsynaptic specialization assembly)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR030476|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|mint:Q99J85	-	-	comment:mint	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:AWabDfkkTcL+AMgJlRt5ntbJ5WU10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q61885	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-445084|uniprotkb:P70364|uniprotkb:Q62003	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mog_mouse(display_long)|uniprotkb:Mog(gene name)|psi-mi:Mog(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR003599(Immunoglobulin subtype)|refseq:NP_034944.2|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR016663(Myelin-oligodendrocyte glycoprotein)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0007155"(cell adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|rcsb pdb:1PY9|mint:Q61885|interpro:IPR036179	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:0pKLIk56EuaULm8g6BqtByU6Eds10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CG46	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11519215|uniprotkb:Q80TW7|uniprotkb:Q8CHX5|uniprotkb:Q922K3|ensembl:ENSMUSP00000084837	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:smc5_mouse(display_long)|uniprotkb:Protein expressed in male leptotene and zygotene spermatocytes 453(gene name synonym)|uniprotkb:Smc5(gene name)|psi-mi:Smc5(display_short)|uniprotkb:Kiaa0594(gene name synonym)|uniprotkb:Smc5l1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001239613.1|refseq:NP_722503.1|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0000724"(double-strand break repair via homologous recombination)|ensembl:ENSMUSG00000024943(gene)|ensembl:ENSMUST00000087556(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR027131|interpro:IPR027417|mint:Q8CG46|reactome:R-MMU-3108214|go:"GO:0090398"(cellular senescence)	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:PMoBnppRaULz3Wkk6gQGbPs5DJU10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P56942	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26450331|ensembl:ENSMUSP00000044352|uniprotkb:Q9D220	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mch_mouse(display_long)|uniprotkb:Pmch(gene name)|psi-mi:Pmch(display_short)|uniprotkb:Mch(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000048621(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007631"(feeding behavior)|go:"GO:0009409"(response to cold)|go:"GO:0030354"(melanin-concentrating hormone activity)|go:"GO:0031777"(type 1 melanin-concentrating hormone receptor binding)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042756"(drinking behavior)|go:"GO:0045202"(synapse)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046005"(positive regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|interpro:IPR005456(Pre-pro melanin-concentrating hormone)|mint:P56942|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUSG00000035383(gene)|refseq:NP_084247.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:l3UbZeUaSJTBhc0jao6eg+D8Q4U10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P11881	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-541478|uniprotkb:P20943|uniprotkb:Q99LG5|ensembl:ENSMUSP00000032192	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:itpr1_mouse(display_long)|uniprotkb:Type 1 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 1(gene name synonym)|uniprotkb:Inositol 1,4,5-trisphosphate-binding protein P400(gene name synonym)|uniprotkb:Purkinje cell protein 1(gene name synonym)|uniprotkb:Protein PCD-6(gene name synonym)|uniprotkb:Itpr1(gene name)|psi-mi:Itpr1(display_short)|uniprotkb:Insp3r(gene name synonym)|uniprotkb:Pcd6(gene name synonym)|uniprotkb:Pcp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_034715.3|refseq:XP_006505693.1|refseq:XP_006505699.1|refseq:XP_006505700.1|dip:DIP-32243N|refseq:XP_017176897.1|refseq:XP_017176899.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0098794"(postsynapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|mint:P11881|rcsb pdb:1N4K|rcsb pdb:1XZZ|rcsb pdb:5GUG|rcsb pdb:5X9Z|rcsb pdb:5XA0|rcsb pdb:5XA1|reactome:R-MMU-114508|reactome:R-MMU-139853|reactome:R-MMU-381676|reactome:R-MMU-418457|reactome:R-MMU-5578775|reactome:R-MMU-983695|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097421"(liver regeneration)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098695"(inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels)|go:"GO:0098793"(presynapse)|ensembl:ENSMUSG00000030102(gene)|ensembl:ENSMUST00000032192(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:O+LA4/Acwos+RNtyqL3IgAe/kkk10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3UM18	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16733930|ensembl:ENSMUSP00000112860|uniprotkb:Q68ED9|uniprotkb:Q80V36	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:lsg1_mouse(display_long)|uniprotkb:Lsg1(gene name)|psi-mi:Lsg1(display_short)|uniprotkb:D16Bwg1547e(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000022538(gene)|ensembl:ENSMUST00000117363(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0051168"(nuclear export)|interpro:IPR006073(GTP1/OBG)|interpro:IPR027417|interpro:IPR030378|interpro:IPR043358|mint:Q3UM18|refseq:NP_835170.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:NwGi0wFHlU6jO7ZbZzEhbBkT6oA10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80X66	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471043|ensembl:ENSMUSP00000048530	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:btbda_mouse(display_long)|uniprotkb:Btbd10(gene name)|psi-mi:Btbd10(display_short)|uniprotkb:Gmrp1(gene name synonym)|uniprotkb:Glucose metabolism-related protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR011333(BTB/POZ fold)|interpro:IPR039885|interpro:IPR039886|mint:Q80X66|ensembl:ENSMUSG00000038187(gene)|ensembl:ENSMUST00000047091(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR000210(BTB/POZ-like)|refseq:NP_598461.1|refseq:XP_006508223.1|refseq:XP_011240192.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:VoTwPedMCjTuxDWUH5cbm1iIUQ410090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8R3R8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471002|ensembl:ENSMUSP00000032264|ensembl:ENSMUSP00000145175|uniprotkb:Q3TG14|uniprotkb:Q3TJB9|uniprotkb:Q3TXZ5|uniprotkb:Q9JJ97	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:gbrl1_mouse(display_long)|uniprotkb:Gabarapl1(gene name)|psi-mi:Gabarapl1(display_short)|uniprotkb:Apg8l(gene name synonym)|uniprotkb:Atg8l(gene name synonym)|uniprotkb:Gec1(gene name synonym)|uniprotkb:"GABA(A) receptor-associated protein-like 1"(gene name synonym)|uniprotkb:Glandular epithelial cell protein 1(gene name synonym)|uniprotkb:MNCb-0091(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000030161(gene)|ensembl:ENSMUST00000032264(transcript)|ensembl:ENSMUST00000204956(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0016236"(macroautophagy)|go:"GO:0005874"(microtubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0044297"(cell body)|go:"GO:0050811"(GABA receptor binding)|interpro:IPR004241("Light chain 3 (LC3)")|interpro:IPR029071|mint:Q8R3R8|rcsb pdb:5YIP|rcsb pdb:7CDB|reactome:R-MMU-1632852|refseq:NP_065615.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:X3TVNoI2dr936S1k875QCIVQWbo10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CXY6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2312782|uniprotkb:Q3U083|uniprotkb:Q5RKG0|uniprotkb:Q8CCY9|uniprotkb:Q99KS3|ensembl:ENSMUSP00000001042	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ilf2_mouse(display_long)|uniprotkb:Ilf2(gene name)|psi-mi:Ilf2(display_short)|uniprotkb:Nf45(gene name synonym)|uniprotkb:Nuclear factor of activated T-cells 45 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080650.1|ensembl:ENSMUSG00000001016(gene)|ensembl:ENSMUST00000001042(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR043519|mint:Q9CXY6|rcsb pdb:4AT7|rcsb pdb:4AT8|rcsb pdb:4AT9|rcsb pdb:4ATB|reactome:R-MMU-6798695	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:HwUDuY6Ev7csoTThxZCW8nJT88o10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3U4G0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470987|ensembl:ENSMUSP00000106543|uniprotkb:Q80WT3|uniprotkb:Q8C1X6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cdin1_mouse(display_long)|uniprotkb:Cdin1(gene name)|psi-mi:Cdin1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000040282(gene)|ensembl:ENSMUST00000110918(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030218"(erythrocyte differentiation)|interpro:IPR029404|mint:Q3U4G0|refseq:NP_001139370.1|refseq:NP_997147.3	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:gJ5bh/GvxiLfIKZVcJBRB/LWpzY10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6PIJ4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-3043931|ensembl:ENSMUSP00000083341|uniprotkb:Q8BWV5|uniprotkb:Q8K0X6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nfrkb_mouse(display_long)|uniprotkb:Nfrkb(gene name)|psi-mi:Nfrkb(display_short)|uniprotkb:DNA-binding protein R kappa-B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000042185(gene)|ensembl:ENSMUST00000086167(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0031011"(Ino80 complex)|interpro:IPR024867|interpro:IPR025220|interpro:IPR038106|interpro:IPR044867|mint:Q6PIJ4|reactome:R-MMU-5689603|reactome:R-MMU-5696394|refseq:NP_766354.2	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:yTbgv+uM2TkGYKxitT7vEktdpRU10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O88532	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-645485|uniprotkb:Q3TY30|uniprotkb:Q8BS85|uniprotkb:Q8CGG5|uniprotkb:Q91VZ0|uniprotkb:Q9CT34|ensembl:ENSMUSP00000118911	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:zfr_mouse(display_long)|uniprotkb:Zfr(gene name)|psi-mi:Zfr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035897.2|ensembl:ENSMUSG00000022201(gene)|ensembl:ENSMUST00000122941(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR006561(DZF)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043519|mint:O88532	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ncNwFUEUk0r2XotuXm/9Tt4iB5w10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9D6G9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470970|ensembl:ENSMUSP00000036138|uniprotkb:Q9DB66	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cklf5_mouse(display_long)|uniprotkb:Cmtm5(gene name)|psi-mi:Cmtm5(display_short)|uniprotkb:Cklfsf5(gene name synonym)|uniprotkb:Chemokine-like factor superfamily member 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000040759(gene)|ensembl:ENSMUST00000037814(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045662"(negative regulation of myoblast differentiation)|interpro:IPR008253(Marvel)|mint:Q9D6G9|refseq:NP_080342.1|refseq:XP_017171651.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Kj8DRGtMwsoKRnanvRkfzDr+4J810090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O35681	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-457995|uniprotkb:P97791|uniprotkb:Q80WV1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:syt3_mouse(display_long)|uniprotkb:Syt3(gene name)|psi-mi:Syt3(display_short)|uniprotkb:Synaptotagmin III(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001107588.1|refseq:NP_057872.3|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR028682|mint:O35681|interpro:IPR035892	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:mkfffZn3WWGhztw/udRiKd0LUJ010090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80TR4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470923|ensembl:ENSMUSP00000025993|uniprotkb:Q9WVB5	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:slit1_mouse(display_long)|uniprotkb:Slit1(gene name)|psi-mi:Slit1(display_short)|uniprotkb:Kiaa0813(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000025993(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007097"(nuclear migration)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051964"(negative regulation of synapse assembly)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR006207(Cystine knot, C-terminal)|ensembl:ENSMUSG00000025020(gene)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|interpro:IPR032675|mint:Q80TR4|refseq:NP_056563.2|refseq:XP_011245502.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:8SeUazCGHiowSI+ACP8ezeOC8pg10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8VDD8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-9075564|uniprotkb:Q3U473|ensembl:ENSMUSP00000072220|ensembl:ENSMUSP00000112255	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:wash1_mouse(display_long)|uniprotkb:Washc1(gene name)|psi-mi:Washc1(display_short)|uniprotkb:Orf19(gene name synonym)|uniprotkb:WAS protein family homolog 1(gene name synonym)|uniprotkb:Wash(gene name synonym)|uniprotkb:Wash1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001032846.1|refseq:NP_081109.1|refseq:XP_006524922.1|refseq:XP_006524923.1|ensembl:ENSMUSG00000024101(gene)|ensembl:ENSMUST00000072383(transcript)|ensembl:ENSMUST00000116556(transcript)|go:"GO:0001556"(oocyte maturation)|go:"GO:0002468"(dendritic cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016197"(endosomal transport)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0040038"(polar body extrusion after meiotic divisions)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043553"(negative regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0071203"(WASH complex)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0099638"(endosome to plasma membrane protein transport)|go:"GO:1904109"(positive regulation of cholesterol import)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR021854|interpro:IPR028290|mint:Q8VDD8	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:700ozoGDp7h62hh+lkUOLa6YDro10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P17012	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16360118|ensembl:ENSMUSP00000085423|ensembl:ENSMUSP00000109559|ensembl:ENSMUSP00000109560|uniprotkb:P17011	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:zfx_mouse(display_long)|uniprotkb:Zfx(gene name)|psi-mi:Zfx(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000079509(gene)|ensembl:ENSMUST00000088102(transcript)|ensembl:ENSMUST00000113926(transcript)|ensembl:ENSMUST00000113927(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007281"(germ cell development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009566"(fertilization)|go:"GO:0009791"(post-embryonic development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0060746"(parental behavior)|interpro:IPR006794(Zfx / Zfy transcription activation region)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:P17012|refseq:NP_001037851.1|refseq:NP_035898.2|refseq:XP_006528029.1|refseq:XP_011245879.1|refseq:XP_011245880.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:FkIURapAxen8c3qWW9P3PecSTYk10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q62443	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470897|ensembl:ENSMUSP00000026670	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nptx1_mouse(display_long)|uniprotkb:Nptx1(gene name)|psi-mi:Nptx1(display_short)|uniprotkb:Neuronal pentraxin I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000025582(gene)|ensembl:ENSMUST00000026670(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0030133"(transport vesicle)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|mint:Q62443|refseq:NP_032756.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ddE8h5JD7XtrGle7yD9q+E4m/co10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6ZPQ6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16744915|ensembl:ENSMUSP00000124111|uniprotkb:Q9R1P5	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:pitm2_mouse(display_long)|uniprotkb:Pitpnm2(gene name)|psi-mi:Pitpnm2(display_short)|uniprotkb:Drosophila retinal degeneration B homolog 2(gene name synonym)|uniprotkb:Kiaa1457(gene name synonym)|uniprotkb:Nir3(gene name synonym)|uniprotkb:Phosphatidylinositol transfer protein, membrane-associated 2(gene name synonym)|uniprotkb:Pyk2 N-terminal domain-interacting receptor 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000029406(gene)|ensembl:ENSMUST00000161938(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008525"(phosphatidylcholine transporter activity)|go:"GO:0008526"(phosphatidylinositol transfer activity)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044297"(cell body)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|interpro:IPR001666(Phosphatidylinositol transfer protein)|interpro:IPR023214|interpro:IPR023393|interpro:IPR031315|interpro:IPR036412|mint:Q6ZPQ6|reactome:R-MMU-1483226|interpro:IPR004177(DDHD)|refseq:NP_001276401.1|refseq:NP_035386.1|refseq:XP_017176233.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:4zrvxwjon6qsbpA3n5INhmMp/KQ10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9Z1X4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6260790|ensembl:ENSMUSP00000065770|uniprotkb:Q8BP80|uniprotkb:Q8K588|uniprotkb:Q8C2H8|uniprotkb:Q812A1|uniprotkb:Q80VD5	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ilf3_mouse(display_long)|uniprotkb:Ilf3(gene name)|psi-mi:Ilf3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001264250.1|ensembl:ENSMUSG00000032178(gene)|ensembl:ENSMUST00000067646(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006479"(protein methylation)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR033099|interpro:IPR043519|mint:Q9Z1X4|rcsb pdb:4AT7|rcsb pdb:4AT8|rcsb pdb:4AT9|rcsb pdb:4ATB|rcsb pdb:5DV7|refseq:XP_006510094.1|refseq:NP_001036172.1|refseq:NP_001036173.1|refseq:NP_034691.2|refseq:NP_001264251.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:vxZan3L6NAseX1Ib9Z7MQ82CM3E10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3UFQ8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-13951462|ensembl:ENSMUSP00000075587|uniprotkb:Q6KAP3	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:carl3_mouse(display_long)|uniprotkb:Carmil3(gene name)|psi-mi:Carmil3(display_short)|uniprotkb:Lrrc16b(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker protein 3(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000022211(gene)|ensembl:ENSMUST00000076236(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029766|interpro:IPR031943|interpro:IPR032675|interpro:IPR041245|mint:Q3UFQ8|refseq:NP_001019816.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:gPESbxfNq/mOFgUYRM0Yw83jUYk10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9D1M0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-4285415|uniprotkb:Q99M12|uniprotkb:Q9D712|ensembl:ENSMUSP00000032440	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:sec13_mouse(display_long)|uniprotkb:Sec13(gene name)|psi-mi:Sec13(display_short)|uniprotkb:Sec13l1(gene name synonym)|uniprotkb:SEC13-like protein 1(gene name synonym)|uniprotkb:SEC13-related protein(gene name synonym)|uniprotkb:GATOR complex protein SEC13(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_077168.2|ensembl:ENSMUSG00000030298(gene)|ensembl:ENSMUST00000032440(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032527"(protein exit from endoplasmic reticulum)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051028"(mRNA transport)|go:"GO:0061700"(GATOR2 complex)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:0090114"(COPII-coated vesicle budding)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR037363|interpro:IPR037596|mint:Q9D1M0|reactome:R-MMU-141444|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-170822|reactome:R-MMU-191859|reactome:R-MMU-204005|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3108214|reactome:R-MMU-3232142|reactome:R-MMU-3301854|reactome:R-MMU-3371453|reactome:R-MMU-4085377|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-5578749|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9615933|reactome:R-MMU-9639288|reactome:R-MMU-9648025|reactome:R-MMU-983170|interpro:IPR036322	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:40KHYuvc/jVIxhLJTKivv2NRm7I10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P07934	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470873|ensembl:ENSMUSP00000026617	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:phkg1_mouse(display_long)|uniprotkb:Phkg1(gene name)|psi-mi:Phkg1(display_short)|uniprotkb:Phkg(gene name synonym)|uniprotkb:Phosphorylase kinase subunit gamma-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PHKG1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000026617(transcript)|go:"GO:0004689"(phosphorylase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR002291(Phosphorylase kinase, gamma catalytic subunit)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P07934|reactome:R-MMU-70221|ensembl:ENSMUSG00000025537(gene)|refseq:NP_035209.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:oWhiqhcqtIelRPU5Z0TI4T9lskc10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P39087	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-396914|uniprotkb:Q60933|ensembl:ENSMUSP00000101124|ensembl:ENSMUSP00000151921	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:grik2_mouse(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym)|uniprotkb:Glutamate receptor beta-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_017169293.1|ensembl:ENSMUSG00000056073(gene)|ensembl:ENSMUST00000105484(transcript)|ensembl:ENSMUST00000218823(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|mint:P39087|reactome:R-MMU-451307|reactome:R-MMU-451308	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:6sgY8SzX07HzilLLeDg3pV+sXkc10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TSH2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-911437|ensembl:ENSMUSP00000050788	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kpbb_mouse(display_long)|uniprotkb:Phkb(gene name)|psi-mi:Phkb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_955517.1|ensembl:ENSMUSG00000036879(gene)|ensembl:ENSMUST00000053771(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|interpro:IPR008734(Phosphorylase kinase alphabeta)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR011613(Glycoside hydrolase 15-related)|mint:Q7TSH2|reactome:R-MMU-70221|refseq:XP_006530595.1|refseq:XP_006530596.1|refseq:XP_006530597.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:qRovReuecws5KcJl6XVcnVO5FW410090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CC12	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470848|ensembl:ENSMUSP00000106329|uniprotkb:A2AW10|uniprotkb:Q149P8|uniprotkb:Q3U032	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cdan1_mouse(display_long)|uniprotkb:Cdan1(gene name)|psi-mi:Cdan1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000027284(gene)|ensembl:ENSMUST00000110701(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0008104"(protein localization)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031497"(chromatin assembly)|interpro:IPR028171|interpro:IPR040031|mint:Q8CC12|refseq:NP_081167.2	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:5Nyg/Fnh9WKYy3DFp/o8OTH4LGA10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P18826	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470825|ensembl:ENSMUSP00000061991|uniprotkb:A2AI90	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kpb1_mouse(display_long)|uniprotkb:Phka1(gene name)|psi-mi:Phka1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000034055(gene)|ensembl:ENSMUST00000052012(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR008734(Phosphorylase kinase alphabeta)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR011613(Glycoside hydrolase 15-related)|interpro:IPR012341(Six-hairpin glycosidase)|mint:P18826|reactome:R-MMU-70221|refseq:NP_032858.2	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:m6KkLpQv72gScTWLDJ2f1g4mtuo10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q64105	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470795|uniprotkb:Q63996	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:spre_mouse(display_long)|uniprotkb:Spr(gene name)|psi-mi:Spr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0004757"(sepiapterin reductase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006558"(L-phenylalanine metabolic process)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0010033"(response to organic substance)|go:"GO:0019889"(pteridine metabolic process)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046146"(tetrahydrobiopterin metabolic process)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050882"(voluntary musculoskeletal movement)|rcsb pdb:1NAS|rcsb pdb:1OAA|rcsb pdb:1SEP|reactome:R-MMU-1474151|reactome:R-MMU-203615|mint:Q64105|interpro:IPR036291|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR006393(Sepiapterin reductase)	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Y4ePCWcq2RI0t59kgHibLyHd6yM10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6ZPR4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16728165|ensembl:ENSMUSP00000109809|uniprotkb:B2RUK3|uniprotkb:Q8C3E7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kcnt1_mouse(display_long)|uniprotkb:Kcnt1(gene name)|psi-mi:Kcnt1(display_short)|uniprotkb:Kiaa1422(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000058740(gene)|ensembl:ENSMUST00000114172(transcript)|go:"GO:0005228"(intracellular sodium activated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR013099(Ion transport 2)|mint:Q6ZPR4|refseq:NP_001289280.1|refseq:NP_780671.2	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:dqty8xDH9pIQhzgbYTeSOo4tLjA10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O35099	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-777493|uniprotkb:Q14AY5|ensembl:ENSMUSP00000093485	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:m3k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:Map3k5(gene name)|psi-mi:Map3k5(display_short)|uniprotkb:Ask1(gene name synonym)|uniprotkb:Mekk5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_032606.4|dip:DIP-38055N|ensembl:ENSMUSG00000071369(gene)|ensembl:ENSMUST00000095806(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010941"(regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902170"(cellular response to reactive nitrogen species)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:O35099|reactome:R-MMU-2559580	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:i1P8YtUNmpFauFUVVxzsMYoQYOw10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q08460	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q62261	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P16546	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-911063|uniprotkb:A3KGU6|uniprotkb:Q8K380|uniprotkb:Q9CT05|uniprotkb:A3KGU8|ensembl:ENSMUSP00000092697	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:sptn1_mouse(display_long)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:Sptan1(gene name)|psi-mi:Sptan1(display_short)|uniprotkb:Spna2(gene name synonym)|uniprotkb:Spta2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471064|imex:IM-28526-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	dip:DIP-37712N|ensembl:ENSMUSG00000057738(gene)|ensembl:ENSMUST00000095083(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005916"(fascia adherens)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030507"(spectrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032437"(cuticular plate)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:P16546|reactome:R-MMU-264870|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:UVB6Kv+PBlqDH3OLoGjxm5oYVPQ10090	rigid:1JOfwvXFNTAAFw2yvNzsN5yCNUk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CPT5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8387401|intact:MINT-4124681|uniprotkb:Q921K0|uniprotkb:Q8C2P2|ensembl:ENSMUSP00000026987	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nop16_mouse(display_long)|uniprotkb:Nop16(gene name)|psi-mi:Nop16(display_short)|uniprotkb:D13Wsu177e(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_848720.1|ensembl:ENSMUST00000026987(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR019002|mint:Q9CPT5|ensembl:ENSMUSG00000025869(gene)	-	-	comment:mint	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ZLP/J+AN+CXIUpCUOY6vDdYXEbQ10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8C1D8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8387298|uniprotkb:Q3UWB0|uniprotkb:Q8BY73|uniprotkb:Q6NVD1|uniprotkb:Q9D9H4|intact:MINT-4114051|uniprotkb:Q3TQ25|ensembl:ENSMUSP00000025243	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:iws1_mouse(display_long)|uniprotkb:Iws1(gene name)|psi-mi:Iws1(display_short)|uniprotkb:Iws1l(gene name synonym)|uniprotkb:IWS1-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_775617.1|ensembl:ENSMUSG00000024384(gene)|ensembl:ENSMUST00000025243(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0090239"(regulation of histone H4 acetylation)|go:"GO:2001253"(regulation of histone H3-K36 trimethylation)|interpro:IPR017923|interpro:IPR035441|mint:Q8C1D8|reactome:R-MMU-112382|reactome:R-MMU-674695|reactome:R-MMU-75955	-	-	comment:mint	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:r9aQ40EqQpf32tyzOSEBZYOT4CY10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P62315	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-7229109|uniprotkb:Q3UYM0|uniprotkb:P13641|intact:MINT-124808|ensembl:ENSMUSP00000002551	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:smd1_mouse(display_long)|uniprotkb:Snrpd1(gene name)|psi-mi:Snrpd1(display_short)|uniprotkb:snRNP core protein D1(gene name synonym)|uniprotkb:Sm-D autoantigen(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_033252.1|ensembl:ENSMUSG00000002477(gene)|ensembl:ENSMUST00000002551(transcript)|go:"GO:0000243"(commitment complex)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0034709"(methylosome)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:1990446"(U1 snRNP binding)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027141|interpro:IPR034102|mint:P62315|reactome:R-MMU-191859|reactome:R-MMU-72163|reactome:R-MMU-72165	-	-	function:May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA|comment:mint	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:bfXwsV+IOjDPCoOJOoMQgECyiII10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6P9J5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8399127|uniprotkb:Q8BV03|intact:MINT-4112744|ensembl:ENSMUSP00000099851	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kank4_mouse(display_long)|uniprotkb:Ankrd38(gene name synonym)|uniprotkb:Ankyrin repeat domain-containing protein 38(gene name synonym)|uniprotkb:Kank4(gene name)|psi-mi:Kank4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_766460.2|ensembl:ENSMUSG00000035407(gene)|ensembl:ENSMUST00000102790(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR021939|interpro:IPR036770|mint:Q6P9J5	-	-	comment:mint	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:dV3Zl8tuTdDGsypp9iu7b7SNqWE10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80VI1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8391705|uniprotkb:Q8CAY0|intact:MINT-4138537	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tri56_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRIM56(gene name synonym)|uniprotkb:Trim56(gene name)|psi-mi:Trim56(display_short)|uniprotkb:Tripartite motif-containing protein 56(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_011239185.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017907|refseq:NP_958761.1|interpro:IPR027370|refseq:XP_006504504.1|mint:Q80VI1|go:"GO:0000785"(chromatin)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1902187"|reactome:R-MMU-3134975|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)	-	-	comment:mint	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:PsLx85Qc2YXJytLxqDejtZp2Fn010090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8R0X7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8429240|intact:MINT-4134482|uniprotkb:Q8C942|uniprotkb:O54955|ensembl:ENSMUSP00000090155|ensembl:ENSMUSP00000112975	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:sgpl1_mouse(display_long)|uniprotkb:Sgpl1(gene name)|psi-mi:Sgpl1(display_short)|uniprotkb:Sphingosine-1-phosphate aldolase(gene name synonym)|uniprotkb:Spl(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001303602.1|refseq:NP_001303603.1|refseq:NP_033189.2|refseq:XP_017169349.1|ensembl:ENSMUSG00000020097(gene)|ensembl:ENSMUST00000092498(transcript)|ensembl:ENSMUST00000122259(transcript)|go:"GO:0001553"(luteinization)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001822"(kidney development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008117"(sphinganine-1-phosphate aldolase activity)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008585"(female gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010761"(fibroblast migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060325"(face morphogenesis)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR002129(Pyridoxal phosphate-dependent decarboxylase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:Q8R0X7|reactome:R-MMU-1660661	-	-	comment:mint|function:"Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis"	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:uRqg9UV6WYA626cSUPbG1VKhQYU10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9D8M7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8339310|intact:MINT-4127642|uniprotkb:Q99LV5|uniprotkb:E9QLI2	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:phf10_mouse(display_long)|uniprotkb:Phf10(gene name)|psi-mi:Phf10(display_short)|uniprotkb:Baf45a(gene name synonym)|uniprotkb:BRG1-associated factor 45a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR019787|refseq:NP_077212.3|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR038045|mint:Q9D8M7|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0071564"(npBAF complex)|interpro:IPR001965(Zinc finger, PHD-type)	-	-	comment:mint|function:May act as a transcription regulator	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:udf/gKP7bnl292/Hb/Mwf9QOwFY10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O88796	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8459162|intact:MINT-4132955|ensembl:ENSMUSP00000025714	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rpp30_mouse(display_long)|uniprotkb:Rpp30(gene name)|psi-mi:Rpp30(display_short)|uniprotkb:Rnasep2(gene name synonym)|uniprotkb:RNase P subunit 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_062301.3|ensembl:ENSMUSG00000024800(gene)|ensembl:ENSMUST00000025714(transcript)|go:"GO:0000172"(ribonuclease MRP complex)|go:"GO:0001682"(tRNA 5'-leader removal)|go:"GO:0003723"(RNA binding)|go:"GO:0004526"(ribonuclease P activity)|go:"GO:0005655"(nucleolar ribonuclease P complex)|go:"GO:0006364"(rRNA processing)|go:"GO:0008033"(tRNA processing)|go:"GO:0030681"(multimeric ribonuclease P complex)|go:"GO:0033204"(ribonuclease P RNA binding)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR002738(RNase P subunit p30)|interpro:IPR016195(Polymerase and histidinol phosphatase-like)|mint:O88796|reactome:R-MMU-6791226	-	-	comment:mint|function:Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:qANO2qyNO6bx6Sj3ieBH17GUxZ810090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99M28	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8339636|uniprotkb:Q3TMJ1|intact:MINT-4124387|uniprotkb:Q922H8|ensembl:ENSMUSP00000085867|ensembl:ENSMUSP00000126345	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rnps1_mouse(display_long)|uniprotkb:Rnps1(gene name)|psi-mi:Rnps1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001073596.1|refseq:NP_001073597.1|refseq:NP_033096.2|refseq:XP_017172851.1|ensembl:ENSMUSG00000034681(gene)|ensembl:ENSMUST00000088512(transcript)|ensembl:ENSMUST00000163717(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0061574"(ASAP complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034201|interpro:IPR035979|mint:Q99M28|reactome:R-MMU-159236|reactome:R-MMU-72163|reactome:R-MMU-72187|reactome:R-MMU-73856|reactome:R-MMU-975957	-	-	comment:mint|function:"Part of pre- and post-splicing multiprotein mRNP complexes. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Participates in mRNA 3'-end cleavage. Involved in RENT2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions"	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:nANu/nh/pD/F6dYE2Sa28OegPGs10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8K370	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8351209|uniprotkb:Q8K313|intact:MINT-1839952|uniprotkb:Q8BWQ0|ensembl:ENSMUSP00000031412|ensembl:ENSMUSP00000107400	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:acd10_mouse(display_long)|uniprotkb:Acad10(gene name)|psi-mi:Acad10(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_082313.2|refseq:XP_006530521.1|refseq:XP_006530523.1|refseq:XP_006530524.1|ensembl:ENSMUSG00000029456(gene)|ensembl:ENSMUST00000031412(transcript)|ensembl:ENSMUST00000111770(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0016787"(hydrolase activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002575(Aminoglycoside phosphotransferase)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR006439(HAD-superfamily hydrolase, subfamily IA, variant 1)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011945(Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR023198|interpro:IPR023214|interpro:IPR036250|interpro:IPR036412|interpro:IPR037069|interpro:IPR041492|interpro:IPR041726|mint:Q8K370|reactome:R-MMU-77289	-	-	comment:mint	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:IsgrBdnCIl/Afx8GNhD8OrVs9aU10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8VBX6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8026435|uniprotkb:Q8VBV5|uniprotkb:Q6P7U4|uniprotkb:Q8VBY0|uniprotkb:B7ZNA1|uniprotkb:Q9Z1K3|uniprotkb:O08783|uniprotkb:Q8BKJ1|uniprotkb:Q8C0H8|intact:MINT-146667|uniprotkb:Q80ZY8|ensembl:ENSMUSP00000099894	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mpdz_mouse(display_long)|uniprotkb:Mpdz(gene name)|psi-mi:Mpdz(display_short)|uniprotkb:Mupp1(gene name synonym)|uniprotkb:Multi-PDZ domain protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001292213.1|refseq:NP_001292215.1|refseq:NP_034950.2|dip:DIP-41165N|ensembl:ENSMUSG00000028402(gene)|ensembl:ENSMUST00000102830(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042552"(myelination)|go:"GO:0043220"(Schmidt-Lanterman incisure)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR032078|interpro:IPR036034|interpro:IPR036892|mint:Q8VBX6|rcsb pdb:4XH7	-	-	comment:mint|function:Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:PE6FMj7RyxofEiUpGMu97CF+TX810090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q569Z5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8372791|uniprotkb:Q6ZQ42|uniprotkb:Q8R0R6|intact:MINT-4118429|ensembl:ENSMUSP00000133245|ensembl:ENSMUSP00000153328	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ddx46_mouse(display_long)|uniprotkb:Ddx46(gene name)|psi-mi:Ddx46(display_short)|uniprotkb:Kiaa0801(gene name synonym)|uniprotkb:DEAD box protein 46(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001268984.1|ensembl:ENSMUSG00000021500(gene)|ensembl:ENSMUST00000172272(transcript)|ensembl:ENSMUST00000223736(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q569Z5|reactome:R-MMU-72163	-	-	comment:mint|function:Plays an essential role in splicing, either prior to, or during A complex formation	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:bR28iB8YRYIjcWqTcPYs+dSC6Go10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9QUR8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8330031|intact:MINT-4134084|uniprotkb:O88371|ensembl:ENSMUSP00000042211	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:sem7a_mouse(display_long)|uniprotkb:Sema7a(gene name)|psi-mi:Sema7a(display_short)|uniprotkb:Cd108(gene name synonym)|uniprotkb:Semal(gene name synonym)|uniprotkb:Semk1(gene name synonym)|uniprotkb:Semaphorin-K1(gene name synonym)|uniprotkb:Semaphorin-L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035482.1|go:"GO:0007411"(axon guidance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0021988"(olfactory lobe development)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048675"(axon extension)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027231|interpro:IPR036179|interpro:IPR036352|interpro:IPR042824|mint:Q9QUR8|reactome:R-MMU-416700|go:"GO:0007229"(integrin-mediated signaling pathway)|ensembl:ENSMUSG00000038264(gene)|ensembl:ENSMUST00000043059(transcript)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)	-	-	comment:mint|function:May play an imortant role in the nervous system and in modulating immune function	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:IaJn4BX9px5pC8+y1GxtEMhaNro10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:B2RR83	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8572369|ensembl:ENSMUSP00000048340|intact:MINT-8174232	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ytdc2_mouse(display_long)|uniprotkb:Keen to exit meiosis leaving testes under-populated protein(gene name synonym)|uniprotkb:YTH domain-containing protein C2(gene name synonym)|uniprotkb:Ythdc2(gene name)|psi-mi:Ythdc2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR007275(YT521-B-like protein)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031083|interpro:IPR034083|interpro:IPR036770|interpro:IPR036867|mint:B2RR83|ensembl:ENSMUSG00000034653(gene)|ensembl:ENSMUST00000037763(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007286"(spermatid development)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048599"(oocyte development)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR001374(Single-stranded nucleic acid binding R3H)|refseq:NP_001156485.1	-	-	comment:mint	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:TxNENB71AFsznI6fFqBPUX8pgdA10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O35143	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8440016|uniprotkb:Q9D879|intact:MINT-4088754|ensembl:ENSMUSP00000064282	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:atif1_mouse(display_long)|uniprotkb:Atp5if1(gene name)|psi-mi:Atp5if1(display_short)|uniprotkb:ATP synthase F1 subunit epsilon(gene name synonym)|uniprotkb:Atpi(gene name synonym)|uniprotkb:Atpif1(gene name synonym)|uniprotkb:If1(gene name synonym)|uniprotkb:"Inhibitor of F(1)F(o)-ATPase"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_031538.2|ensembl:ENSMUSG00000054428(gene)|ensembl:ENSMUST00000067496(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0019899"(enzyme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140260"(mitochondrial proton-transporting ATP synthase complex binding)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1903052"(positive regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903578"(regulation of ATP metabolic process)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|interpro:IPR007648(Mitochondrial ATPase inhibitor, IATP)|mint:O35143	-	-	function:Thought to be a regulatory component of the ATP-synthesizing complex in the mitochondria|comment:mint	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:NnZnbr9qaWZdQ85TwrgZRZUW9oM10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P56960	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8316161|ensembl:ENSMUSP00000017408|uniprotkb:B1ARY9|uniprotkb:Q9R0B1|intact:MINT-4094804|uniprotkb:Q9QYS8	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:exosx_mouse(display_long)|uniprotkb:Exosc10(gene name)|psi-mi:Exosc10(display_short)|uniprotkb:Pmscl2(gene name synonym)|uniprotkb:Polymyositis/scleroderma autoantigen 2 homolog(gene name synonym)|uniprotkb:Autoantigen PM/Scl 2 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000017264(gene)|ensembl:ENSMUST00000017408(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000176"("nuclear exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000467"("exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0035327"|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071034"(CUT catabolic process)|go:"GO:0071035"(nuclear polyadenylation-dependent rRNA catabolic process)|go:"GO:0071036"(nuclear polyadenylation-dependent snoRNA catabolic process)|go:"GO:0071037"(nuclear polyadenylation-dependent snRNA catabolic process)|go:"GO:0071038"(nuclear polyadenylation-dependent tRNA catabolic process)|go:"GO:0071039"(nuclear polyadenylation-dependent CUT catabolic process)|go:"GO:0071040"(nuclear polyadenylation-dependent antisense transcript catabolic process)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071048"|go:"GO:0071051"(polyadenylation-dependent snoRNA 3'-end processing)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002562(3'-5' exonuclease)|interpro:IPR010997(HRDC-like)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012588(Exosome-associated factor Rrp6, N-terminal)|interpro:IPR036397|mint:P56960|reactome:R-MMU-6791226|refseq:NP_057908.2	-	-	function:"Part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions. Required for the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA. Could be an exonuclease. Mediates the association of MTR4, C1D and MPP6 wth the exosome and this complex is required for the maturation of 5.8S rRNA. Required for nucleolar localization of C1D"|comment:mint	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:0d5mjwJWcKJp1FOOShsVURcgLYg10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8C050	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8391218|intact:MINT-4116279|uniprotkb:Q8CI92|ensembl:ENSMUSP00000042987	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ks6a5_mouse(display_long)|uniprotkb:Rps6ka5(gene name)|psi-mi:Rps6ka5(display_short)|uniprotkb:Msk1(gene name synonym)|uniprotkb:Nuclear mitogen- and stress-activated protein kinase 1(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 5(gene name synonym)|uniprotkb:RSK-like protein kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_705815.1|refseq:NP_001317631.1|ensembl:ENSMUSG00000021180(gene)|ensembl:ENSMUST00000043599(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0043990"(histone H2A-S1 phosphorylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:Q8C050|reactome:R-MMU-198753|reactome:R-MMU-199920|reactome:R-MMU-375165|reactome:R-MMU-5621575|go:"GO:0106310"(protein serine kinase activity)	-	-	comment:mint|function:"Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14)"	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:MIhH01PUvJRSlgDj4ftn2glW5Fw10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CGF7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-7964269|intact:MINT-7969933|uniprotkb:Q61051|uniprotkb:Q8C490|uniprotkb:Q8CHT8|uniprotkb:Q9R0R5|ensembl:ENSMUSP00000158288	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tcrg1_mouse(display_long)|uniprotkb:Tcerg1(gene name)|psi-mi:Tcerg1(display_short)|uniprotkb:Formin-binding protein 28(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 2S(gene name synonym)|uniprotkb:Taf2s(gene name synonym)|uniprotkb:Transcription factor CA150(gene name synonym)|uniprotkb:p144(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001034563.1|refseq:XP_006526178.1|refseq:NP_001276455.1|ensembl:ENSMUSG00000024498(gene)|ensembl:ENSMUST00000237602(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0042802"(identical protein binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR002713(FF)|interpro:IPR036020|interpro:IPR036517|mint:Q8CGF7|rcsb pdb:1E0L|rcsb pdb:2JUP|rcsb pdb:2RLY|rcsb pdb:2RM0|rcsb pdb:2YSI|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)	-	-	comment:mint	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:l0JizdwOK12oL38q8XfhOUyv6oM10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q64152	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8316731|ensembl:ENSMUSP00000022163|intact:MINT-1851805|uniprotkb:Q64153|uniprotkb:Q6P3F3|uniprotkb:Q6GU63	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:btf3_mouse(display_long)|uniprotkb:Btf3(gene name)|psi-mi:Btf3(display_short)|uniprotkb:RNA polymerase B transcription factor 3(gene name synonym)|uniprotkb:Nascent polypeptide-associated complex subunit beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000021660(gene)|ensembl:ENSMUST00000022163(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005854"(nascent polypeptide-associated complex)|go:"GO:0015031"(protein transport)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR002715(Nascent polypeptide-associated complex NAC)|interpro:IPR038187|interpro:IPR039370|mint:Q64152|refseq:NP_663430.2|refseq:NP_001164011.1|dip:DIP-59968N	-	-	function:General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription|comment:mint	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ggS6MpV/CpLeK5L5/tUeOt3AazQ10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q62446	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8313562|ensembl:ENSMUSP00000021332|intact:MINT-1870257|uniprotkb:Q9WTJ7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:fkbp3_mouse(display_long)|uniprotkb:Fkbp3(gene name)|psi-mi:Fkbp3(display_short)|uniprotkb:Fkbp25(gene name synonym)|uniprotkb:Rapamycin-selective 25 kDa immunophilin(gene name synonym)|uniprotkb:FK506-binding protein 3(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:Immunophilin FKBP25(gene name synonym)|uniprotkb:25 kDa FK506-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000020949(gene)|ensembl:ENSMUST00000021332(transcript)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR041200|interpro:IPR043368|mint:Q62446|rcsb pdb:3KZ7|refseq:NP_038930.1	-	-	comment:mint|function:"FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins"	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:wt3DD/Qq1QKgSonbFZ0jriqsZxk10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9DB27	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8317814|intact:MINT-4128072|uniprotkb:Q3UUI6|intact:UNK-5416843|ensembl:ENSMUSP00000000365	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mcts1_mouse(display_long)|uniprotkb:Mcts1(gene name)|psi-mi:Mcts1(display_short)|uniprotkb:Multiple copies T-cell malignancies 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_081178.1|refseq:XP_006541598.1|ensembl:ENSMUSG00000000355(gene)|ensembl:ENSMUST00000000365(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0040008"(regulation of growth)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR002478(PUA)|interpro:IPR004521(Uncharacterized domain 2)|interpro:IPR015947(PUA-like)|interpro:IPR016437(Translation machinery-associated RNA binding protein, predicted)|interpro:IPR041366|mint:Q9DB27	-	-	comment:mint	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:kbGy09T3EiKnImwwO2ibi9XTUwg10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q91WM1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8339684|intact:MINT-4121401|uniprotkb:Q62262|ensembl:ENSMUSP00000028279|ensembl:ENSMUSP00000072047	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:strbp_mouse(display_long)|uniprotkb:Strbp(gene name)|psi-mi:Strbp(display_short)|uniprotkb:Spnr(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_011237348.1|refseq:XP_011237349.1|refseq:NP_033287.2|refseq:XP_017172309.1|refseq:XP_017172310.1|refseq:XP_017172311.1|refseq:XP_017172312.1|ensembl:ENSMUSG00000026915(gene)|ensembl:ENSMUST00000028279(transcript)|ensembl:ENSMUST00000072186(transcript)|go:"GO:0002177"(manchette)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0007638"(mechanosensory behavior)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR030446|interpro:IPR043519|interpro:IPR044472|mint:Q91WM1	-	-	comment:mint|function:"Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth (By similarity). Binds to double-stranded DNA and RNA (By similarity). Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA (By similarity). Binds also to single-stranded poly(G) RNA (By similarity). Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA"	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:+sf/OyoCMvzDmHmCmq4Me4jWjco10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q4VAA7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8354245|intact:MINT-4111808|uniprotkb:Q8C832|uniprotkb:Q8BPM5|ensembl:ENSMUSP00000060225	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:snx33_mouse(display_long)|uniprotkb:Sh3px3(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3(gene name synonym)|uniprotkb:Snx33(gene name)|psi-mi:Snx33(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_780692.2|refseq:XP_006511154.1|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028642|interpro:IPR036028|interpro:IPR036871|interpro:IPR037427|mint:Q4VAA7|ensembl:ENSMUSG00000032733(gene)|ensembl:ENSMUST00000050916(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017038"(protein import)|go:"GO:0019898"(extrinsic component of membrane)	-	-	comment:mint	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:MOBa6B53PujsaVbZIVEn43raVTU10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99J85	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8311244|intact:MINT-4104086	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nptxr_mouse(display_long)|uniprotkb:Nptxr(gene name)|psi-mi:Nptxr(display_short)|uniprotkb:Npr(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0008029"(pentraxin receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099150"(regulation of postsynaptic specialization assembly)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR030476|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|mint:Q99J85	-	-	comment:mint	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:AWabDfkkTcL+AMgJlRt5ntbJ5WU10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3TWF6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8585898|intact:UNK-5363545	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:wdr70_mouse(display_long)|uniprotkb:Wdr70(gene name)|psi-mi:Wdr70(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0005634"(nucleus)|go:"GO:0019899"(enzyme binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:1903775"(regulation of DNA double-strand break processing)|go:"GO:2001173"(regulation of histone H2B conserved C-terminal lysine ubiquitination)|interpro:IPR020472|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|mint:Q3TWF6|refseq:NP_001074871.1|interpro:IPR036322	-	-	comment:mint	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:pH4gNwjuSyqIRUk8rHfHae7lnsk10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P50580	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-7550171|intact:MINT-1857756|ensembl:ENSMUSP00000026425|ensembl:ENSMUSP00000114434	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:pa2g4_mouse(display_long)|uniprotkb:Ebp1(gene name synonym)|uniprotkb:Pa2g4(gene name)|psi-mi:Pa2g4(display_short)|uniprotkb:Plfap(gene name synonym)|uniprotkb:Proliferation-associated protein 1(gene name synonym)|uniprotkb:Protein p38-2G4(gene name synonym)|uniprotkb:Mpp1(gene name synonym)|uniprotkb:IRES-specific cellular trans-acting factor 45 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035249.1|ensembl:ENSMUSG00000025364(gene)|ensembl:ENSMUST00000026425(transcript)|ensembl:ENSMUST00000131728(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0006417"(regulation of translation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000994(Peptidase M24, catalytic core)|interpro:IPR004545(Proliferation-associated protein 1)|interpro:IPR018349|interpro:IPR036005|interpro:IPR036388|interpro:IPR036390|mint:P50580|rcsb pdb:2V6C|rcsb pdb:6SWA|reactome:R-MMU-6798695	-	-	comment:mint|function:"May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly (By similarity). Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). Together with PTBP1 is required for the translation initiation on the foot-and-mouth disease virus (FMDV) IRES"	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:00qNeBIV6MQIU5EgEQI6zWdyPJ010090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P26041	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8322611|uniprotkb:Q8BSN4|intact:MINT-1866505|uniprotkb:B1AX70|uniprotkb:Q3UL28|ensembl:ENSMUSP00000113071	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:moes_mouse(display_long)|uniprotkb:Msn(gene name)|psi-mi:Msn(display_short)|uniprotkb:Membrane-organizing extension spike protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_034963.2|ensembl:ENSMUSG00000031207(gene)|ensembl:ENSMUST00000117399(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001931"(uropod)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031143"(pseudopodium)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0042098"(T cell proliferation)|go:"GO:0043209"(myelin sheath)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051286"(cell tip)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070489"(T cell aggregation)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0072678"(T cell migration)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:2000401"(regulation of lymphocyte migration)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P26041|reactome:R-MMU-437239|rcsb pdb:4YL8	-	-	function:Probably involved in connections of major cytoskeletal structures to the plasma membrane|comment:mint	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Oy6Ki6PiaAzF58D07s8b5V42/dw10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3UHH1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8419341|uniprotkb:Q8CE12|uniprotkb:Q8CHC3|intact:MINT-4115901|uniprotkb:Q9D789|uniprotkb:Q80Y41|uniprotkb:Q5U4B9|uniprotkb:Q6PCY6|uniprotkb:B2RX90|ensembl:ENSMUSP00000022358	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:zswm8_mouse(display_long)|uniprotkb:Zswim8(gene name)|psi-mi:Zswim8(display_short)|uniprotkb:Kiaa0913(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001239010.1|refseq:NP_001239011.1|refseq:NP_082272.1|ensembl:ENSMUSG00000021819(gene)|ensembl:ENSMUST00000022358(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000627"(positive regulation of miRNA catabolic process)|interpro:IPR007527(Zinc finger, SWIM-type)|mint:Q3UHH1	-	-	comment:mint	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:C5V4tZMPbr+6VWuzv3N9p7BzPfw10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q91YW3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8381770|intact:EBI-8447300|intact:MINT-1838284|uniprotkb:Q60873|ensembl:ENSMUSP00000022734	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dnjc3_mouse(display_long)|uniprotkb:Dnajc3(gene name)|psi-mi:Dnajc3(display_short)|uniprotkb:P58ipk(gene name synonym)|uniprotkb:Interferon-induced, double-stranded RNA-activated protein kinase inhibitor(gene name synonym)|uniprotkb:Protein kinase inhibitor of 58 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_032955.2|ensembl:ENSMUSG00000022136(gene)|ensembl:ENSMUST00000022734(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036494"(positive regulation of translation initiation in response to endoplasmic reticulum stress)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070417"(cellular response to cold)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|mint:Q91YW3|rcsb pdb:3IEG|reactome:R-MMU-381426|reactome:R-MMU-6798695|reactome:R-MMU-8957275	-	-	comment:mint|function:"May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2/PKR to catalyze phosphorylation of the EIF2A. Co-chaperone of HSPA8/HSC70. Involved in the unfolded protein response (UPR) during ER stress. Regulates the activity and the autophosphorylation of EIF2AK2. Stimulates the ATPase activity of HSPA8 (By similarity). May inhibit EIF2AK3 activity during the ER stress response. Overexpression of DNAJC3 reduces EIF2AK3/PERK-mediated EIF2A phosphorylation"	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:5qmdmpCgH/9zUNnNXN0WHR9W2H410090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CFT2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471495|ensembl:ENSMUSP00000133933|ensembl:ENSMUSP00000134686|uniprotkb:Q80TK9|uniprotkb:Q8CFQ8|uniprotkb:Q8CGD1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:set1b_mouse(display_long)|uniprotkb:Setd1b(gene name)|psi-mi:Setd1b(display_short)|uniprotkb:Kiaa1076(gene name synonym)|uniprotkb:Set1b(gene name synonym)|uniprotkb:SET domain-containing protein 1B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000163030(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0016607"(nuclear speck)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001214(SET)|ensembl:ENSMUSG00000038384(gene)|ensembl:ENSMUST00000056053(transcript)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024657|interpro:IPR034468|interpro:IPR035979|interpro:IPR037842|interpro:IPR044570|reactome:R-MMU-3214841|reactome:R-MMU-8936459|mint:Q8CFT2|refseq:NP_001035488.2	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:lgvkXK+e8EWCjfMp4eKDm3M7dp810090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8R3R8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471002|ensembl:ENSMUSP00000032264|ensembl:ENSMUSP00000145175|uniprotkb:Q3TG14|uniprotkb:Q3TJB9|uniprotkb:Q3TXZ5|uniprotkb:Q9JJ97	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:gbrl1_mouse(display_long)|uniprotkb:Gabarapl1(gene name)|psi-mi:Gabarapl1(display_short)|uniprotkb:Apg8l(gene name synonym)|uniprotkb:Atg8l(gene name synonym)|uniprotkb:Gec1(gene name synonym)|uniprotkb:"GABA(A) receptor-associated protein-like 1"(gene name synonym)|uniprotkb:Glandular epithelial cell protein 1(gene name synonym)|uniprotkb:MNCb-0091(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000030161(gene)|ensembl:ENSMUST00000032264(transcript)|ensembl:ENSMUST00000204956(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0016236"(macroautophagy)|go:"GO:0005874"(microtubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0044297"(cell body)|go:"GO:0050811"(GABA receptor binding)|interpro:IPR004241("Light chain 3 (LC3)")|interpro:IPR029071|mint:Q8R3R8|rcsb pdb:5YIP|rcsb pdb:7CDB|reactome:R-MMU-1632852|refseq:NP_065615.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:X3TVNoI2dr936S1k875QCIVQWbo10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80TG1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-12594388|ensembl:ENSMUSP00000018556|ensembl:ENSMUSP00000102590|uniprotkb:A2A5Y5|uniprotkb:Q3TT88|uniprotkb:Q3U5D8|uniprotkb:Q3V3N3|uniprotkb:Q7TMU3|uniprotkb:Q80XP7|uniprotkb:Q8R3L6|uniprotkb:Q9D9G0	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kanl1_mouse(display_long)|uniprotkb:Kansl1(gene name)|psi-mi:Kansl1(display_short)|uniprotkb:Kiaa1267(gene name synonym)|uniprotkb:Nsl1(gene name synonym)|uniprotkb:NSL complex protein NSL1(gene name synonym)|uniprotkb:Non-specific lethal 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000018412(gene)|ensembl:ENSMUST00000018556(transcript)|ensembl:ENSMUST00000106977(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044545"(NSL complex)|go:"GO:0071339"(MLL1 complex)|interpro:IPR026180|interpro:IPR029332|mint:Q80TG1|reactome:R-MMU-3214847|refseq:NP_001074514.1|refseq:XP_006534516.1|refseq:XP_011247610.1|refseq:XP_017170320.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:1TCMDMuMxyV4SK9UokylFWhssLM10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P50586	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471459|ensembl:ENSMUSP00000033341	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tub_mouse(display_long)|uniprotkb:Tub(gene name)|psi-mi:Tub(display_short)|uniprotkb:Rd5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0005929"(cilium)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009725"(response to hormone)|go:"GO:0042073"(intraciliary transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0097500"(receptor localization to non-motile cilium)|go:"GO:0120160"(intraciliary transport particle A binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1903546"(protein localization to photoreceptor outer segment)|interpro:IPR000007(Tubby, C-terminal)|interpro:IPR005398(Tubby, N-terminal)|interpro:IPR018066|interpro:IPR025659|mint:P50586|rcsb pdb:1C8Z|rcsb pdb:1I7E|ensembl:ENSMUSG00000031028(gene)|ensembl:ENSMUST00000033341(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|refseq:NP_068685.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:UUOUjjKL6od6icxu0mba0htw+Xo10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8K3M5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471443|ensembl:ENSMUSP00000104519|uniprotkb:A2ABW9	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cabl2_mouse(display_long)|uniprotkb:Cables2(gene name)|psi-mi:Cables2(display_short)|uniprotkb:Interactor with CDK3 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000038990(gene)|ensembl:ENSMUST00000108891(transcript)|go:"GO:0007049"(cell cycle)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR012388(Cdk5 and c-Abl linker protein cables)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|mint:Q8K3M5|refseq:NP_665850.2	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:aM3Tji0Zw9l3wwphIgSxpW8kY+s10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:E9Q8I9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16732044|ensembl:ENSMUSP00000084454|uniprotkb:Q4VA57|uniprotkb:Q5DTL4|uniprotkb:Q8BIW6|uniprotkb:Q8BUA0|uniprotkb:Q8CG91	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:fry_mouse(display_long)|uniprotkb:Fry(gene name)|psi-mi:Fry(display_short)|uniprotkb:Kiaa4143(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000056602(gene)|ensembl:ENSMUST00000087204(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005938"(cell cortex)|go:"GO:0030427"(site of polarized growth)|go:"GO:0031175"(neuron projection development)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025481|interpro:IPR025614|interpro:IPR029473|interpro:IPR039867|mint:E9Q8I9|refseq:NP_766475.2|refseq:XP_006504993.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:fvduzhqkwcM9qmnWvPWAA1W8HqI10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P62334	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-357694|uniprotkb:Q92524|uniprotkb:P49719|uniprotkb:Q3TKK1|uniprotkb:Q810A6|uniprotkb:Q9CXH9|ensembl:ENSMUSP00000022380	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:prs10_mouse(display_long)|uniprotkb:Psmc6(gene name)|psi-mi:Psmc6(display_short)|uniprotkb:Sug2(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 6(gene name synonym)|uniprotkb:Proteasome subunit p42(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080235.2|ensembl:ENSMUSG00000021832(gene)|ensembl:ENSMUST00000022380(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016234"(inclusion body)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0090261"(positive regulation of inclusion body assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035263|interpro:IPR041569|mint:P62334|reactome:R-MMU-1169091|go:"GO:0031597"(cytosolic proteasome complex)|reactome:R-MMU-1234176|reactome:R-MMU-1236978|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-187577|reactome:R-MMU-195253|reactome:R-MMU-202424|reactome:R-MMU-2467813|reactome:R-MMU-2871837|reactome:R-MMU-349425|reactome:R-MMU-350562|reactome:R-MMU-382556|reactome:R-MMU-450408|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-4641258|reactome:R-MMU-8852276|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939236|reactome:R-MMU-8939902|reactome:R-MMU-8941858|reactome:R-MMU-8948751|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-983168|reactome:R-MMU-5358346|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-5668541|reactome:R-MMU-5676590|reactome:R-MMU-5687128|reactome:R-MMU-5689603|reactome:R-MMU-5689880|reactome:R-MMU-68827|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69481|reactome:R-MMU-69601|reactome:R-MMU-75815	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:QE8jzSEp1bpzhOi/oAAnV18QK2410090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q60649	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471419|ensembl:ENSMUSP00000001884	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:clpb_mouse(display_long)|uniprotkb:Clpb(gene name)|psi-mi:Clpb(display_short)|uniprotkb:Skd3(gene name synonym)|uniprotkb:Suppressor of potassium transport defect 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000001829(gene)|ensembl:ENSMUST00000001884(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0034605"(cellular response to heat)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR002110(Ankyrin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR019489|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|mint:Q60649|go:"GO:0039529"(RIG-I signaling pathway)|refseq:NP_033217.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:3LgsSo4e7euiNzInO8SYizF9nPU10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:B1AY13	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-9662176|uniprotkb:Q8BLI7|ensembl:ENSMUSP00000092538	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ubp24_mouse(display_long)|uniprotkb:Usp24(gene name)|psi-mi:Usp24(display_short)|uniprotkb:Deubiquitinating enzyme 24(gene name synonym)|uniprotkb:Ubiquitin thioesterase 24(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 24(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_899048.2|ensembl:ENSMUSG00000028514(gene)|ensembl:ENSMUST00000094933(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018200|interpro:IPR021905|interpro:IPR028889|interpro:IPR029071|interpro:IPR033382|interpro:IPR038765|mint:B1AY13|reactome:R-MMU-5689880	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:piuoMxUZPd2jM/4a9+alnjXjQ0810090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3U4G0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470987|ensembl:ENSMUSP00000106543|uniprotkb:Q80WT3|uniprotkb:Q8C1X6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cdin1_mouse(display_long)|uniprotkb:Cdin1(gene name)|psi-mi:Cdin1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000040282(gene)|ensembl:ENSMUST00000110918(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030218"(erythrocyte differentiation)|interpro:IPR029404|mint:Q3U4G0|refseq:NP_001139370.1|refseq:NP_997147.3	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:gJ5bh/GvxiLfIKZVcJBRB/LWpzY10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9D6N5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471393|ensembl:ENSMUSP00000025853	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nc2a_mouse(display_long)|uniprotkb:Drap1(gene name)|psi-mi:Drap1(display_short)|uniprotkb:Dr1-associated protein 1(gene name synonym)|uniprotkb:Negative cofactor 2-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000024914(gene)|ensembl:ENSMUST00000025853(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR003958(Transcription factor CBF/NF-Y/archaeal histone)|interpro:IPR009072(Histone-fold)|mint:Q9D6N5|reactome:R-MMU-1181150|reactome:R-MMU-1502540|go:"GO:0017054"(negative cofactor 2 complex)|refseq:NP_001278009.1|refseq:NP_077138.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:trjtIziCyfxcms8fw3QoTp7pWgA10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q91YJ5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471359|ensembl:ENSMUSP00000020749|ensembl:ENSMUSP00000090926|uniprotkb:Q5M6W6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:if2m_mouse(display_long)|uniprotkb:Mtif2(gene name)|psi-mi:Mtif2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000020459(gene)|ensembl:ENSMUST00000020749(transcript)|ensembl:ENSMUST00000093239(transcript)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0070124"(mitochondrial translational initiation)|interpro:IPR000178(Initiation factor 2)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR015760(Translation initiation factor 2 related)|interpro:IPR023115|interpro:IPR027417|interpro:IPR036925|interpro:IPR044145|mint:Q91YJ5|rcsb pdb:2CRV|refseq:NP_001269047.1|refseq:NP_001269048.1|refseq:NP_001269049.1|refseq:NP_598528.2|refseq:XP_006514954.1|refseq:XP_006514955.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:4p47YRuP6nGUN7iR5eMtqY7YE4I10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q922K7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16729640|uniprotkb:Q3U4W9	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nop2_mouse(display_long)|uniprotkb:Nucleolar protein 1(gene name synonym)|uniprotkb:Nucleolar protein 2 homolog(gene name synonym)|uniprotkb:Proliferating-cell nucleolar antigen p120(gene name synonym)|uniprotkb:Proliferation-associated nucleolar protein p120(gene name synonym)|uniprotkb:Nop2(gene name)|psi-mi:Nop2(display_short)|uniprotkb:Nol1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0001510"(RNA methylation)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009383"("rRNA (cytosine-C5-)-methyltransferase activity")|go:"GO:0070475"(rRNA base methylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|mint:Q922K7|interpro:IPR018314|interpro:IPR031341|interpro:IPR001678("Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p")|interpro:IPR011023(Nop2p)|interpro:IPR012586(P120R)|interpro:IPR023267|interpro:IPR023273|interpro:IPR029063	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:BAr9p7p6IhfUcMmdkp8XMMPQsxk10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q69ZX6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471321|ensembl:ENSMUSP00000091087|ensembl:ENSMUSP00000094176|uniprotkb:Q5QNQ7|uniprotkb:Q6P547	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mor2a_mouse(display_long)|uniprotkb:Morc2a(gene name)|psi-mi:Morc2a(display_short)|uniprotkb:Kiaa0852(gene name synonym)|uniprotkb:Zcwcc1(gene name synonym)|uniprotkb:MORC family CW-type zinc finger protein 2A(gene name synonym)|uniprotkb:Zinc finger CW-type coiled-coil domain protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000034543(gene)|ensembl:ENSMUST00000093389(transcript)|ensembl:ENSMUST00000096441(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR011124(Zinc finger, CW-type)|interpro:IPR036890|mint:Q69ZX6|reactome:R-MMU-75105|interpro:IPR041006|refseq:NP_001152760.1|refseq:XP_011242078.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:eSpbOMSagafsnr187G6CN27ujas10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q64096	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-602123|uniprotkb:E9PV70	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mcf2l_mouse(display_long)|uniprotkb:DBL's big sister(gene name synonym)|uniprotkb:MCF2-transforming sequence-like protein(gene name synonym)|uniprotkb:Mcf2l(gene name)|psi-mi:Mcf2l(display_short)|uniprotkb:Dbs(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	mint:Q64096|dip:DIP-34544N|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018159|interpro:IPR035532|interpro:IPR035534|interpro:IPR035899|interpro:IPR036028|interpro:IPR036865|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1LB1|rcsb pdb:1RJ2|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013408	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:nIIFS7gLKii0O6GIj7BzA7zC9Rs10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9WV55	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-645974|uniprotkb:Q9QY77|uniprotkb:Q3TJM1|ensembl:ENSMUSP00000024897	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:vapa_mouse(display_long)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym)|uniprotkb:Vapa(gene name)|psi-mi:Vapa(display_short)|uniprotkb:Vap33(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_038961.2|ensembl:ENSMUSG00000024091(gene)|ensembl:ENSMUST00000024897(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9WV55|rcsb pdb:2CRI|reactome:R-MMU-1660661|reactome:R-MMU-6798695|reactome:R-MMU-9609523	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:LQV6uN7oD/EpHQvexl/pGkG6bmE10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O88685	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-991914|uniprotkb:Q99JN8|ensembl:ENSMUSP00000071054	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:prs6a_mouse(display_long)|uniprotkb:Proteasome 26S subunit ATPase 3(gene name synonym)|uniprotkb:Tat-binding protein 1(gene name synonym)|uniprotkb:Psmc3(gene name)|psi-mi:Psmc3(display_short)|uniprotkb:Tbp1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_032974.2|ensembl:ENSMUSG00000002102(gene)|ensembl:ENSMUST00000067663(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0001824"(blastocyst development)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043921"(modulation by host of viral transcription)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035254|interpro:IPR041569|mint:O88685|reactome:R-MMU-1169091|reactome:R-MMU-1234176|reactome:R-MMU-1236978|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-187577|reactome:R-MMU-195253|reactome:R-MMU-202424|reactome:R-MMU-2467813|reactome:R-MMU-2871837|reactome:R-MMU-349425|reactome:R-MMU-350562|reactome:R-MMU-382556|reactome:R-MMU-450408|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-4641258|reactome:R-MMU-5358346|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-5668541|reactome:R-MMU-5676590|reactome:R-MMU-5687128|reactome:R-MMU-5689603|reactome:R-MMU-5689880|reactome:R-MMU-6798695|reactome:R-MMU-68827|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69481|reactome:R-MMU-69601|reactome:R-MMU-75815|reactome:R-MMU-8852276|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939236|reactome:R-MMU-8939902|reactome:R-MMU-8941858|reactome:R-MMU-8948751|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-983168	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:8njcru3CI0vk4dpAV5oY7Z2Kuk010090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6P5D3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471284|ensembl:ENSMUSP00000083742|uniprotkb:Q3TS93|uniprotkb:Q6NZK4|uniprotkb:Q6P1B4|uniprotkb:Q8BI63|uniprotkb:Q8BIA2|uniprotkb:Q8R360	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dhx57_mouse(display_long)|uniprotkb:Dhx57(gene name)|psi-mi:Dhx57(display_short)|uniprotkb:DEAH box protein 57(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000035051(gene)|ensembl:ENSMUST00000086555(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006575(RWD)|interpro:IPR007502(Helicase-associated region)|interpro:IPR009060(UBA-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR027417|interpro:IPR036855|interpro:IPR042615|mint:Q6P5D3|refseq:NP_001157231.1|refseq:NP_945180.2|refseq:XP_006523510.1|refseq:XP_006523511.1|refseq:XP_017172691.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:nAZbsulRL3ILa8GPejiItndIZts10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P26043	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-647737|uniprotkb:Q3TS85|uniprotkb:Q9QW27|ensembl:ENSMUSP00000000590|ensembl:ENSMUSP00000128249	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:radi_mouse(display_long)|uniprotkb:ESP10(gene name synonym)|uniprotkb:Rdx(gene name)|psi-mi:Rdx(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001098086.1|refseq:NP_033067.2|dip:DIP-29091N|ensembl:ENSMUSG00000032050(gene)|ensembl:ENSMUST00000000590(transcript)|ensembl:ENSMUST00000163153(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032231"(regulation of actin filament bundle assembly)|go:"GO:0032420"(stereocilium)|go:"GO:0034111"(negative regulation of homotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0045176"(apical protein localization)|go:"GO:0045177"(apical part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903392"(negative regulation of adherens junction organization)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P26043|rcsb pdb:1GC6|rcsb pdb:1GC7|rcsb pdb:1J19|rcsb pdb:2D10|rcsb pdb:2D11|rcsb pdb:2D2Q|rcsb pdb:2EMS|rcsb pdb:2EMT|rcsb pdb:2YVC|rcsb pdb:2ZPY|rcsb pdb:3X23|reactome:R-MMU-437239	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:d7wqsdTau9b92O3q6LW+/pyKL1w10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99JY8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-773683|uniprotkb:Q3TVM4|uniprotkb:Q3TXR7|uniprotkb:Q8BTB7|ensembl:ENSMUSP00000065719	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:plpp3_mouse(display_long)|uniprotkb:Plpp3(gene name)|psi-mi:Plpp3(display_short)|uniprotkb:Lipid phosphate phosphohydrolase 3(gene name synonym)|uniprotkb:Lpp3(gene name synonym)|uniprotkb:PAP2-beta(gene name synonym)|uniprotkb:Phosphatidate phosphohydrolase type 2b(gene name synonym)|uniprotkb:Phosphatidic acid phosphatase 2b(gene name synonym)|uniprotkb:Ppap2b(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_542122.1|ensembl:ENSMUSG00000028517(gene)|ensembl:ENSMUST00000064139(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001568"(blood vessel development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005178"(integrin binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006670"(sphingosine metabolic process)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008195"(phosphatidate phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042392"(sphingosine-1-phosphate phosphatase activity)|go:"GO:0042577"(lipid phosphatase activity)|go:"GO:0044328"(canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration)|go:"GO:0044329"(canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion)|go:"GO:0044330"(canonical Wnt signaling pathway involved in positive regulation of wound healing)|go:"GO:0045121"(membrane raft)|go:"GO:0046839"(phospholipid dephosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0106235"(ceramide-1-phosphate phosphatase activity)|go:"GO:1902068"(regulation of sphingolipid mediated signaling pathway)|interpro:IPR000326(Phosphatidic acid phosphatase type 2/haloperoxidase)|interpro:IPR028675|interpro:IPR036938|interpro:IPR043216|mint:Q99JY8|reactome:R-MMU-1660661	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:k0j2BFjYFftNCFSr6/PrQfurHck10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O88532	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-645485|uniprotkb:Q3TY30|uniprotkb:Q8BS85|uniprotkb:Q8CGG5|uniprotkb:Q91VZ0|uniprotkb:Q9CT34|ensembl:ENSMUSP00000118911	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:zfr_mouse(display_long)|uniprotkb:Zfr(gene name)|psi-mi:Zfr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035897.2|ensembl:ENSMUSG00000022201(gene)|ensembl:ENSMUST00000122941(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR006561(DZF)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043519|mint:O88532	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ncNwFUEUk0r2XotuXm/9Tt4iB5w10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q07235	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471220|ensembl:ENSMUSP00000027467|uniprotkb:Q921T7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:gdn_mouse(display_long)|uniprotkb:Serpine2(gene name)|psi-mi:Serpine2(display_short)|uniprotkb:Pi7(gene name synonym)|uniprotkb:Pn1(gene name synonym)|uniprotkb:Spi4(gene name synonym)|uniprotkb:Peptidase inhibitor 7(gene name synonym)|uniprotkb:Protease nexin 1(gene name synonym)|uniprotkb:Protease nexin I(gene name synonym)|uniprotkb:Serine protease-inhibitor 4(gene name synonym)|uniprotkb:Serpin E2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0021683"(cerebellar granular layer morphogenesis)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032940"(secretion by cell)|go:"GO:0033363"(secretory granule organization)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042628"(mating plug formation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0061108"(seminal vesicle epithelium development)|go:"GO:0061110"(dense core granule biogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090331"(negative regulation of platelet aggregation)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:Q07235|reactome:R-MMU-140837|reactome:R-MMU-140875|reactome:R-MMU-75205|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010757"(negative regulation of plasminogen activation)|ensembl:ENSMUSG00000026249(gene)|ensembl:ENSMUST00000027467(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|refseq:NP_033281.1|refseq:XP_006496522.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:f5t+yFZxEMpxZwjoEoJGYUWxq+410090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CY00	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-22227042|ensembl:ENSMUSP00000097576|uniprotkb:Q3UI02	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tt30b_mouse(display_long)|uniprotkb:Ttc30b(gene name)|psi-mi:Ttc30b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0120170"(intraciliary transport particle B binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR039941|mint:Q9CY00|reactome:R-MMU-5620924|go:"GO:0042073"(intraciliary transport)|ensembl:ENSMUSG00000075273(gene)|ensembl:ENSMUST00000099996(transcript)|go:"GO:0005879"(axonemal microtubule)|go:"GO:0030992"(intraciliary transport particle B)|go:"GO:0036064"(ciliary basal body)|refseq:NP_082511.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:TCSYdzs9ee4tNov7EXzf93rDI2c10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P55194	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2642510|uniprotkb:E9QMQ2|uniprotkb:Q99KK8|ensembl:ENSMUSP00000001226|uniprotkb:A2A5V4	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:3bp1_mouse(display_long)|uniprotkb:Sh3bp1(gene name)|psi-mi:Sh3bp1(display_short)|uniprotkb:3bp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000022436(gene)|ensembl:ENSMUST00000001226(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030834"(regulation of actin filament depolymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000198(RhoGAP)|interpro:IPR004148(BAR)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR027267|mint:P55194|rcsb pdb:1ABO|reactome:R-MMU-9013149|refseq:NP_001303613.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:xZnGbYRBdoFCbDG2oFc9FfUrl1o10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P08775	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2549849|ensembl:ENSMUSP00000050771|uniprotkb:Q5F298	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rpb1_mouse(display_long)|uniprotkb:Polr2a(gene name)|psi-mi:Polr2a(display_short)|uniprotkb:Rpii215(gene name synonym)|uniprotkb:Rpo2-1(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000005198(gene)|ensembl:ENSMUST00000058470(transcript)|go:"GO:0000791"(euchromatin)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0046872"(metal ion binding)|go:"GO:0071453"(cellular response to oxygen levels)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR038120|interpro:IPR038593|interpro:IPR042102|mint:P08775|reactome:R-MMU-113418|reactome:R-MMU-5578749|reactome:R-MMU-674695|reactome:R-MMU-6781823|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-6796648|reactome:R-MMU-6803529|reactome:R-MMU-6807505|reactome:R-MMU-72086|reactome:R-MMU-72163|reactome:R-MMU-72165|reactome:R-MMU-72203|reactome:R-MMU-73776|reactome:R-MMU-73779|reactome:R-MMU-75953|reactome:R-MMU-75955|reactome:R-MMU-76042|reactome:R-MMU-77075|reactome:R-MMU-9018519|reactome:R-MMU-112382|refseq:NP_001277997.1|dip:DIP-46369N	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:kUX/HdU6Y2VHAGjySBcOxfS08XA10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9D6G9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470970|ensembl:ENSMUSP00000036138|uniprotkb:Q9DB66	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cklf5_mouse(display_long)|uniprotkb:Cmtm5(gene name)|psi-mi:Cmtm5(display_short)|uniprotkb:Cklfsf5(gene name synonym)|uniprotkb:Chemokine-like factor superfamily member 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000040759(gene)|ensembl:ENSMUST00000037814(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045662"(negative regulation of myoblast differentiation)|interpro:IPR008253(Marvel)|mint:Q9D6G9|refseq:NP_080342.1|refseq:XP_017171651.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Kj8DRGtMwsoKRnanvRkfzDr+4J810090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3UGC7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-17170843|ensembl:ENSMUSP00000028668	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ei3ja_mouse(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 1-A(gene name synonym)|uniprotkb:eIF-3-alpha-A(gene name synonym)|uniprotkb:eIF3 p35(gene name synonym)|uniprotkb:Eif3j1(gene name)|psi-mi:Eif3j1(display_short)|uniprotkb:Eif3s1-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000027236(gene)|ensembl:ENSMUST00000028668(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042802"(identical protein binding)|interpro:IPR013906(Translation initiation factor eIF3 subunit)|interpro:IPR023194|mint:Q3UGC7|reactome:R-MMU-156827|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|refseq:NP_653128.2	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:eibVbzmFcJ5qAD797IS+jZFKxvE10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9R0N3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-647443|uniprotkb:Q7TQG8|ensembl:ENSMUSP00000088464|ensembl:ENSMUSP00000103129	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:syt11_mouse(display_long)|uniprotkb:Synaptotagmin XI(gene name synonym)|uniprotkb:Syt11(gene name)|psi-mi:Syt11(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_061274.2|refseq:XP_006501411.1|ensembl:ENSMUSG00000068923(gene)|ensembl:ENSMUST00000090945(transcript)|ensembl:ENSMUST00000107505(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0006914"(autophagy)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0009611"(response to wounding)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|go:"GO:1900243"(negative regulation of synaptic vesicle endocytosis)|go:"GO:1900424"(regulation of defense response to bacterium)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905154"(negative regulation of membrane invagination)|go:"GO:1905162"(regulation of phagosome maturation)|go:"GO:1905171"(positive regulation of protein localization to phagocytic vesicle)|go:"GO:1905469"(negative regulation of clathrin-coated pit assembly)|go:"GO:1990927"(calcium ion regulated lysosome exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR028699|interpro:IPR035892|mint:Q9R0N3|reactome:R-MMU-8856825|reactome:R-MMU-8856828	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:hmxn6TCXurR8053TJ6OB1+IMiJ410090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8BS45	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-22226773|ensembl:ENSMUSP00000124369	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ift56_mouse(display_long)|uniprotkb:Ttc26(gene name)|psi-mi:Ttc26(display_short)|uniprotkb:Hop(gene name synonym)|uniprotkb:Ift56(gene name synonym)|uniprotkb:Protein hop-sterile(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 26(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000056832(gene)|ensembl:ENSMUST00000162554(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007286"(spermatid development)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0015031"(protein transport)|go:"GO:0030992"(intraciliary transport particle B)|go:"GO:0035082"(axoneme assembly)|go:"GO:0035720"(intraciliary anterograde transport)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0097546"(ciliary base)|go:"GO:0120170"(intraciliary transport particle B binding)|go:"GO:1905198"(manchette assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR030511|mint:Q8BS45|reactome:R-MMU-5620924|refseq:NP_705828.2	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:p2KI2cBHfmwpd4dDL9zp84Jvvo410090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P11881	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-541478|uniprotkb:P20943|uniprotkb:Q99LG5|ensembl:ENSMUSP00000032192	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:itpr1_mouse(display_long)|uniprotkb:Type 1 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 1(gene name synonym)|uniprotkb:Inositol 1,4,5-trisphosphate-binding protein P400(gene name synonym)|uniprotkb:Purkinje cell protein 1(gene name synonym)|uniprotkb:Protein PCD-6(gene name synonym)|uniprotkb:Itpr1(gene name)|psi-mi:Itpr1(display_short)|uniprotkb:Insp3r(gene name synonym)|uniprotkb:Pcd6(gene name synonym)|uniprotkb:Pcp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_034715.3|refseq:XP_006505693.1|refseq:XP_006505699.1|refseq:XP_006505700.1|dip:DIP-32243N|refseq:XP_017176897.1|refseq:XP_017176899.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0098794"(postsynapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|mint:P11881|rcsb pdb:1N4K|rcsb pdb:1XZZ|rcsb pdb:5GUG|rcsb pdb:5X9Z|rcsb pdb:5XA0|rcsb pdb:5XA1|reactome:R-MMU-114508|reactome:R-MMU-139853|reactome:R-MMU-381676|reactome:R-MMU-418457|reactome:R-MMU-5578775|reactome:R-MMU-983695|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097421"(liver regeneration)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098695"(inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels)|go:"GO:0098793"(presynapse)|ensembl:ENSMUSG00000030102(gene)|ensembl:ENSMUST00000032192(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:O+LA4/Acwos+RNtyqL3IgAe/kkk10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P46662	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-644586|uniprotkb:Q8BR03|ensembl:ENSMUSP00000105536	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:merl_mouse(display_long)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)|uniprotkb:Nf2(gene name)|psi-mi:Nf2(display_short)|uniprotkb:Nf-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035028.2|refseq:XP_006514633.1|ensembl:ENSMUSG00000009073(gene)|ensembl:ENSMUST00000109910(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007398"(ectoderm development)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030175"(filopodium)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035330"(regulation of hippo signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042127"(regulation of cell population proliferation)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P46662|rcsb pdb:1ISN|rcsb pdb:3WA0|interpro:IPR000798(Ezrin/radixin/moesin ERM)|rcsb pdb:4P7I|rcsb pdb:4ZRK|reactome:R-MMU-2029482|reactome:R-MMU-5627123|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR000299(Band 4.1, N-terminal)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|refseq:NP_001239179.1|refseq:NP_001239180.1|refseq:XP_011241971.1|refseq:NP_001239181.1|refseq:NP_001239182.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:xDzmqR+fx4dbxWKxBm5h+sWkzEw10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P70372	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6877056|ensembl:ENSMUSP00000096549|ensembl:ENSMUSP00000146866|uniprotkb:Q60745|uniprotkb:Q78QY3	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:elav1_mouse(display_long)|uniprotkb:Elavl1(gene name)|psi-mi:Elavl1(display_short)|uniprotkb:Elra(gene name synonym)|uniprotkb:Hua(gene name synonym)|uniprotkb:Elav-like generic protein(gene name synonym)|uniprotkb:Hu-antigen R(gene name synonym)|uniprotkb:MelG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000040028(gene)|ensembl:ENSMUST00000098950(transcript)|ensembl:ENSMUST00000209010(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035198"(miRNA binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034996|interpro:IPR035979|mint:P70372|reactome:R-MMU-450520|reactome:R-MMU-72163|go:"GO:0019901"(protein kinase binding)|refseq:XP_006508761.1|refseq:NP_034615.2|dip:DIP-46480N	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:iKHrpZqi5b7EFLkfVJSRTpi9sj010090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80TN7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11568593	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nav3_mouse(display_long)|uniprotkb:Kiaa0938(gene name synonym)|uniprotkb:Pomfil1(gene name synonym)|uniprotkb:Pore membrane and/or filament-interacting-like protein 1(gene name synonym)|uniprotkb:Nav3(gene name)|psi-mi:Nav3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR027417|refseq:XP_006513738.1|mint:Q80TN7|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0032703"(negative regulation of interleukin-2 production)|interpro:IPR036872|interpro:IPR039041	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:vb9nb25PTROlcYWeCIL6pbnN1Dk10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99MX7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471209|ensembl:ENSMUSP00000135924	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:t121b_mouse(display_long)|uniprotkb:Tmem121b(gene name)|psi-mi:Tmem121b(display_short)|uniprotkb:Cecr6(gene name synonym)|uniprotkb:Cat eye syndrome critical region protein 6 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000094626(gene)|ensembl:ENSMUST00000178687(transcript)|interpro:IPR026624|interpro:IPR032776|mint:Q99MX7|refseq:NP_291045.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:FCrAG/xW6SA/2MWYd4lB4//rDiE10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q08509	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-375596|uniprotkb:Q3TM41|ensembl:ENSMUSP00000052776|ensembl:ENSMUSP00000098402|ensembl:ENSMUSP00000107509	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:eps8_mouse(display_long)|uniprotkb:Eps8(gene name)|psi-mi:Eps8(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010458"(exit from mitosis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0030426"(growth cone)|go:"GO:0030832"(regulation of actin filament length)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0045202"(synapse)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030222|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q08509|rcsb pdb:1AOJ|rcsb pdb:1I07|rcsb pdb:1I0C|ensembl:ENSMUSG00000015766(gene)|ensembl:ENSMUST00000058210(transcript)|ensembl:ENSMUST00000100841(transcript)|ensembl:ENSMUST00000111878(transcript)|refseq:NP_031971.2|refseq:NP_001258524.1|refseq:NP_001258517.1|refseq:NP_001258516.1|refseq:NP_001258518.1|refseq:XP_011239506.1|dip:DIP-32858N	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:glTI+FSRPZ3apY8RGGDdMI6ialw10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CIG8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2527009|uniprotkb:Q3TNN1|uniprotkb:Q9QZS9	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:anm5_mouse(display_long)|uniprotkb:Prmt5(gene name)|psi-mi:Prmt5(display_short)|uniprotkb:Jbp1(gene name synonym)|uniprotkb:Skb1(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT5(gene name synonym)|uniprotkb:Shk1 kinase-binding protein 1 homolog(gene name synonym)|uniprotkb:Jak-binding protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR035075|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000785"(chromatin)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006479"(protein methylation)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034709"(methylosome)|go:"GO:0034969"(histone arginine methylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035243"(protein-arginine omega-N symmetric methyltransferase activity)|go:"GO:0035246"(peptidyl-arginine N-methylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070888"(E-box binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1904992"(positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway)|reactome:R-MMU-191859|reactome:R-MMU-3214858|reactome:R-MMU-6804760|refseq:NP_038796.2|interpro:IPR007857(Skb1 methyltransferase)|interpro:IPR029063|refseq:NP_001300835.1|refseq:NP_001300836.1|interpro:IPR025799|interpro:IPR035247|interpro:IPR035248|mint:Q8CIG8	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:xMQdLXo5TNQQFK9XjxjH+5/ZwNA10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q04690	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-397326|uniprotkb:Q61956|uniprotkb:Q61957|ensembl:ENSMUSP00000071289	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nf1_mouse(display_long)|uniprotkb:Nf1(gene name)|psi-mi:Nf1(display_short)|uniprotkb:Neurofibromatosis-related protein NF-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035027.1|refseq:XP_006532504.1|go:"GO:0007420"(brain development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0008542"(visual learning)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0021510"(spinal cord development)|go:"GO:0021764"(amygdala development)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0021915"(neural tube development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0045685"(regulation of glial cell differentiation)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023152|interpro:IPR036865|interpro:IPR039360|mint:Q04690|go:"GO:0030424"(axon)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035021"(negative regulation of Rac protein signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043473"(pigmentation)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045545"(syndecan binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|ensembl:ENSMUSG00000020716(gene)|ensembl:ENSMUST00000071325(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001656"(metanephros development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001889"(liver development)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007154"(cell communication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|reactome:R-MMU-5658442	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:aegHzgNy813/APoCjeM166e+MFE10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99ME2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471188|ensembl:ENSMUSP00000070927	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:wdr6_mouse(display_long)|uniprotkb:Wdr6(gene name)|psi-mi:Wdr6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000066357(gene)|ensembl:ENSMUST00000068700(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0030488"(tRNA methylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:Q99ME2|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-9696264|reactome:R-MMU-9696270|reactome:R-MMU-9696273|refseq:NP_113569.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:sHyG7HHVKVuAwjddmzrFN1PycJY10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q05860	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471139|ensembl:ENSMUSP00000099606|uniprotkb:A2AFY9|uniprotkb:A2AFZ0|uniprotkb:Q05859	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:fmn1_mouse(display_long)|uniprotkb:Fmn1(gene name)|psi-mi:Fmn1(display_short)|uniprotkb:Fmn(gene name synonym)|uniprotkb:Ld(gene name synonym)|uniprotkb:Limb deformity protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000044042(gene)|ensembl:ENSMUST00000102547(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010467"(gene expression)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0045010"(actin nucleation)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0051127"(positive regulation of actin nucleation)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060173"(limb development)|go:"GO:0072092"(ureteric bud invasion)|interpro:IPR001265(Formin)|interpro:IPR015425(Actin-binding FH2)|mint:Q05860|rcsb pdb:2JUP|rcsb pdb:2RLY|rcsb pdb:2RM0|refseq:NP_001272388.1|refseq:NP_034360.2|refseq:XP_011237596.1|refseq:XP_011237597.1|dip:DIP-646N	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Z05yN/PQ7y9ArGsIeoql9r+n6Kw10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3UQN2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6094986|uniprotkb:Q3UJ91|uniprotkb:Q7TMS9|uniprotkb:Q8C0I2|ensembl:ENSMUSP00000042959	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:fcho2_mouse(display_long)|uniprotkb:Fcho2(gene name)|psi-mi:Fcho2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_766179.2|dip:DIP-29489N|ensembl:ENSMUSG00000041685(gene)|ensembl:ENSMUST00000040340(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0010324"(membrane invagination)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098835"(presynaptic endocytic zone membrane)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR018808|interpro:IPR027267|interpro:IPR028565|interpro:IPR030122|interpro:IPR031160|mint:Q3UQN2|reactome:R-MMU-8856825|reactome:R-MMU-8856828	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:0+FhOCmcIH+a08hD9KmSTtW5XDw10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:A3KFM7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2550131|ensembl:ENSMUSP00000042291|uniprotkb:B9EKA7|uniprotkb:Q3UQS6|uniprotkb:Q80TE9	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:chd6_mouse(display_long)|uniprotkb:Chd6(gene name)|psi-mi:Chd6(display_short)|uniprotkb:ATP-dependent helicase CHD6(gene name synonym)|uniprotkb:Kiaa1335(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_011238078.1|ensembl:ENSMUSG00000057133(gene)|ensembl:ENSMUST00000039782(transcript)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0070615"|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000953(Chromo domain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023780|interpro:IPR027417|interpro:IPR038718|mint:A3KFM7|interpro:IPR000330(SNF2-related)|refseq:NP_775544.2|refseq:XP_017174747.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:bwFeRlosmKuYC0Jrg9zJZ6c28bg10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q69ZC8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471128|ensembl:ENSMUSP00000022585|uniprotkb:Q8K2V8	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:gpam1_mouse(display_long)|uniprotkb:Gpalpp1(gene name)|psi-mi:Gpalpp1(display_short)|uniprotkb:Kiaa1704(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000022008(gene)|ensembl:ENSMUST00000022585(transcript)|interpro:IPR022226|mint:Q69ZC8|refseq:NP_080453.2	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:wDouyrSB2MI8WYBYR3FxMqnoCVY10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9R0L6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-4284371|uniprotkb:O70287|uniprotkb:Q3URH6|uniprotkb:Q7TMS7|uniprotkb:Q8C9V2|uniprotkb:Q91Y27|uniprotkb:Q91Y28|uniprotkb:Q91Y51|uniprotkb:Q9CRK8|uniprotkb:Q923L0|uniprotkb:Q9CT57|uniprotkb:E9QLK2|ensembl:ENSMUSP00000039709	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:pcm1_mouse(display_long)|uniprotkb:Pcm1(gene name)|psi-mi:Pcm1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_076151.2|refseq:XP_006509361.1|ensembl:ENSMUSG00000031592(gene)|ensembl:ENSMUST00000045218(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q9R0L6|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-5620912|reactome:R-MMU-8854518|reactome:R-MMU-380320	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:OT+ZOQY5pqQojMcLCWMIY+6zdl410090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P11983	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-772338|uniprotkb:Q3TJ96|uniprotkb:Q3TKU1|uniprotkb:Q3U5T8|uniprotkb:Q3U7I8|uniprotkb:Q3UAA8|uniprotkb:Q3UB80|uniprotkb:Q3UE48|intact:EBI-2291308|uniprotkb:P11984|ensembl:ENSMUSP00000116108	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tcpa_mouse(display_long)|uniprotkb:CCT-alpha(gene name synonym)|uniprotkb:Tailless complex polypeptide 1B(gene name synonym)|uniprotkb:Tcp1(gene name)|psi-mi:Tcp1(display_short)|uniprotkb:Ccta(gene name synonym)|uniprotkb:Cct1(gene name synonym)|uniprotkb:Tailless complex polypeptide 1A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001277641.1|refseq:NP_038714.2|dip:DIP-32342N|ensembl:ENSMUSG00000068039(gene)|ensembl:ENSMUST00000151287(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0043209"(myelin sheath)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P11983|reactome:R-MMU-390471|reactome:R-MMU-5620922|reactome:R-MMU-6814122	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:mSINCow3H5FzUCTXpqwkI18OI9o10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9JIK5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2551674|uniprotkb:Q3TVJ3|ensembl:ENSMUSP00000042691|uniprotkb:Q9WV45	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ddx21_mouse(display_long)|uniprotkb:Nucleolar RNA helicase II(gene name synonym)|uniprotkb:Nucleolar RNA helicase Gu(gene name synonym)|uniprotkb:RH II/Gu(gene name synonym)|uniprotkb:Gu-alpha(gene name synonym)|uniprotkb:DEAD box protein 21(gene name synonym)|uniprotkb:Ddx21(gene name)|psi-mi:Ddx21(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000020075(gene)|ensembl:ENSMUST00000045866(transcript)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0019843"(rRNA binding)|go:"GO:0030515"(snoRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0062176"(R-loop disassembly)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012562(GUCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR035979|mint:Q9JIK5|rcsb pdb:3ZIN|reactome:R-MMU-5250924|reactome:R-MMU-6791226|go:"GO:0051607"(defense response to virus)|refseq:NP_062426.2|dip:DIP-48574N	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:VMHd6Qxsw72ljg+FE39/O559ynI10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CIE6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-644254|uniprotkb:E9Q075|ensembl:ENSMUSP00000118179	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:copa_mouse(display_long)|uniprotkb:Alpha-coat protein(gene name synonym)|uniprotkb:Copa(gene name)|psi-mi:Copa(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_034068.3|ensembl:ENSMUSG00000026553(gene)|ensembl:ENSMUST00000135192(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003729"(mRNA binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0044297"(cell body)|go:"GO:0099612"(protein localization to axon)|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR001680(WD40 repeat)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR010714(Coatomer, alpha subunit, C-terminal)|interpro:IPR011048(Cytochrome cd1-nitrite reductase-like, C-terminal haem d1)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016391(Coatomer, alpha subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|mint:Q8CIE6|rcsb pdb:5A1U|rcsb pdb:5A1V|rcsb pdb:5A1W|rcsb pdb:5A1X|rcsb pdb:5A1Y|rcsb pdb:5NZR|rcsb pdb:5NZS|rcsb pdb:5NZT|rcsb pdb:5NZU|rcsb pdb:5NZV|reactome:R-MMU-6807878|reactome:R-MMU-6811434	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:c+/zgZ1/6rEy0vlikp+E+4gijto10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9D6S7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471110|ensembl:ENSMUSP00000028250|uniprotkb:B1B055	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rrfm_mouse(display_long)|uniprotkb:Mrrf(gene name)|psi-mi:Mrrf(display_short)|uniprotkb:Ribosome-releasing factor, mitochondrial(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000026887(gene)|ensembl:ENSMUST00000028250(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006412"(translation)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0043023"(ribosomal large subunit binding)|interpro:IPR002661(Ribosome recycling factor)|interpro:IPR023584|interpro:IPR036191|mint:Q9D6S7|rcsb pdb:1WIH|reactome:R-MMU-5419276|refseq:NP_080698.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:IZfaK7W9vh+OKt5CBZii+juKlo810090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3UIU2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2934427|ensembl:ENSMUSP00000092746	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ndub6_mouse(display_long)|uniprotkb:Ndufb6(gene name)|psi-mi:Ndufb6(display_short)|uniprotkb:Gm137(gene name synonym)|uniprotkb:Complex I-B17(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase B17 subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000071014(gene)|ensembl:ENSMUST00000095128(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|interpro:IPR019174|rcsb pdb:6G2J|rcsb pdb:6G72|rcsb pdb:6ZR2|rcsb pdb:6ZTQ|rcsb pdb:7AK5|rcsb pdb:7AK6|rcsb pdb:7B93|reactome:R-MMU-611105|reactome:R-MMU-6799198|mint:Q3UIU2|refseq:NP_001028477.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:FIprQvG6ZL1DDoxrJvYTkzz/ei810090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P26040	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-645505|uniprotkb:Q80ZT8|uniprotkb:Q9DCI1|ensembl:ENSMUSP00000063734	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ezri_mouse(display_long)|uniprotkb:Vil2(gene name synonym)|uniprotkb:p81(gene name synonym)|uniprotkb:Cytovillin(gene name synonym)|uniprotkb:Villin-2(gene name synonym)|uniprotkb:Ezr(gene name)|psi-mi:Ezr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_033536.2|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044297"(cell body)|go:"GO:0044393"(microspike)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097454"(Schwann cell microvillus)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902896"(terminal web assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|interpro:IPR008954(Moesin)|mint:P26040|reactome:R-MMU-373752|reactome:R-MMU-437239|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|ensembl:ENSMUSG00000052397(gene)|ensembl:ENSMUST00000064234(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0001931"(uropod)|go:"GO:0001951"(intestinal D-glucose absorption)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:PspmkV3JA32h1VGLkUgha3a59AA10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80X66	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471043|ensembl:ENSMUSP00000048530	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:btbda_mouse(display_long)|uniprotkb:Btbd10(gene name)|psi-mi:Btbd10(display_short)|uniprotkb:Gmrp1(gene name synonym)|uniprotkb:Glucose metabolism-related protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR011333(BTB/POZ fold)|interpro:IPR039885|interpro:IPR039886|mint:Q80X66|ensembl:ENSMUSG00000038187(gene)|ensembl:ENSMUST00000047091(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR000210(BTB/POZ-like)|refseq:NP_598461.1|refseq:XP_006508223.1|refseq:XP_011240192.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:VoTwPedMCjTuxDWUH5cbm1iIUQ410090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80TR4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470923|ensembl:ENSMUSP00000025993|uniprotkb:Q9WVB5	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:slit1_mouse(display_long)|uniprotkb:Slit1(gene name)|psi-mi:Slit1(display_short)|uniprotkb:Kiaa0813(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000025993(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007097"(nuclear migration)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051964"(negative regulation of synapse assembly)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR006207(Cystine knot, C-terminal)|ensembl:ENSMUSG00000025020(gene)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|interpro:IPR032675|mint:Q80TR4|refseq:NP_056563.2|refseq:XP_011245502.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:8SeUazCGHiowSI+ACP8ezeOC8pg10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9D1M0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-4285415|uniprotkb:Q99M12|uniprotkb:Q9D712|ensembl:ENSMUSP00000032440	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:sec13_mouse(display_long)|uniprotkb:Sec13(gene name)|psi-mi:Sec13(display_short)|uniprotkb:Sec13l1(gene name synonym)|uniprotkb:SEC13-like protein 1(gene name synonym)|uniprotkb:SEC13-related protein(gene name synonym)|uniprotkb:GATOR complex protein SEC13(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_077168.2|ensembl:ENSMUSG00000030298(gene)|ensembl:ENSMUST00000032440(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032527"(protein exit from endoplasmic reticulum)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051028"(mRNA transport)|go:"GO:0061700"(GATOR2 complex)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:0090114"(COPII-coated vesicle budding)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR037363|interpro:IPR037596|mint:Q9D1M0|reactome:R-MMU-141444|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-170822|reactome:R-MMU-191859|reactome:R-MMU-204005|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3108214|reactome:R-MMU-3232142|reactome:R-MMU-3301854|reactome:R-MMU-3371453|reactome:R-MMU-4085377|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-5578749|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9615933|reactome:R-MMU-9639288|reactome:R-MMU-9648025|reactome:R-MMU-983170|interpro:IPR036322	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:40KHYuvc/jVIxhLJTKivv2NRm7I10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CCK0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-20313485|uniprotkb:A0JP36|uniprotkb:Q3TNT4|uniprotkb:Q925I6|ensembl:ENSMUSP00000020283	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:h2aw_mouse(display_long)|uniprotkb:Macroh2a2(gene name)|psi-mi:Macroh2a2(display_short)|uniprotkb:H2afy2(gene name synonym)|uniprotkb:H2afy3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_996883.1|ensembl:ENSMUSG00000020086(gene)|ensembl:ENSMUST00000020283(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001740"(Barr body)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0007420"(brain development)|go:"GO:0007549"(dosage compensation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:1901837"(negative regulation of transcription of nucleolar large rRNA by RNA polymerase I)|interpro:IPR002119(Histone H2A)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR021171|interpro:IPR032454|interpro:IPR035796|interpro:IPR043472|mint:Q8CCK0	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:VDYaQkuXNy0GqZ4NPpvUOToqdq410090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O35681	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-457995|uniprotkb:P97791|uniprotkb:Q80WV1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:syt3_mouse(display_long)|uniprotkb:Syt3(gene name)|psi-mi:Syt3(display_short)|uniprotkb:Synaptotagmin III(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001107588.1|refseq:NP_057872.3|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR028682|mint:O35681|interpro:IPR035892	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:mkfffZn3WWGhztw/udRiKd0LUJ010090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6VH22	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-22226681|ensembl:ENSMUSP00000049335|uniprotkb:Q6NZK1|uniprotkb:Q80TI4|uniprotkb:Q80W19|uniprotkb:Q9DAB0	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:if172_mouse(display_long)|uniprotkb:Ift172(gene name)|psi-mi:Ift172(display_short)|uniprotkb:Kiaa1179(gene name synonym)|uniprotkb:Wim(gene name synonym)|uniprotkb:Protein wimple(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0060271"(cilium assembly)|go:"GO:0060348"(bone development)|go:"GO:0061525"(hindgut development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097228"(sperm principal piece)|go:"GO:0097598"(sperm cytoplasmic droplet)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR036322|mint:Q6VH22|reactome:R-MMU-5610787|reactome:R-MMU-5620924|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008544"(epidermis development)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021915"(neural tube development)|go:"GO:0030992"(intraciliary transport particle B)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031514"(motile cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060173"(limb development)|go:"GO:0007368"(determination of left/right symmetry)|ensembl:ENSMUSG00000038564(gene)|ensembl:ENSMUST00000041565(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001841"(neural tube formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|refseq:NP_080574.5	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:qKlWtm735I1OrvYPmj7ZUyI3ZDA10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CXY6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2312782|uniprotkb:Q3U083|uniprotkb:Q5RKG0|uniprotkb:Q8CCY9|uniprotkb:Q99KS3|ensembl:ENSMUSP00000001042	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ilf2_mouse(display_long)|uniprotkb:Ilf2(gene name)|psi-mi:Ilf2(display_short)|uniprotkb:Nf45(gene name synonym)|uniprotkb:Nuclear factor of activated T-cells 45 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080650.1|ensembl:ENSMUSG00000001016(gene)|ensembl:ENSMUST00000001042(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR043519|mint:Q9CXY6|rcsb pdb:4AT7|rcsb pdb:4AT8|rcsb pdb:4AT9|rcsb pdb:4ATB|reactome:R-MMU-6798695	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:HwUDuY6Ev7csoTThxZCW8nJT88o10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P24270	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2924912|uniprotkb:Q3TXQ6|ensembl:ENSMUSP00000028610	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cata_mouse(display_long)|uniprotkb:Cat(gene name)|psi-mi:Cat(display_short)|uniprotkb:Cas-1(gene name synonym)|uniprotkb:Cas1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0055093"(response to hyperoxia)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0080184"(response to phenylpropanoid)|interpro:IPR002226(Catalase)|interpro:IPR010582(Catalase-related)|interpro:IPR011614(Catalase, N-terminal)|interpro:IPR018028|interpro:IPR020835|interpro:IPR024708|interpro:IPR024711|interpro:IPR040333|mint:P24270|reactome:R-MMU-3299685|reactome:R-MMU-6798695|reactome:R-MMU-9033241|go:"GO:0051781"(positive regulation of cell division)|ensembl:ENSMUSG00000027187(gene)|ensembl:ENSMUST00000028610(transcript)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0004096"(catalase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009642"(response to light intensity)|go:"GO:0009650"(UV protection)|go:"GO:0010193"(response to ozone)|go:"GO:0010288"(response to lead ion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0016209"(antioxidant activity)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019899"(enzyme binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|refseq:NP_033934.2	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Ahsw8/VMIQAUw7mWuBSFRn9g/3M10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P07934	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470873|ensembl:ENSMUSP00000026617	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:phkg1_mouse(display_long)|uniprotkb:Phkg1(gene name)|psi-mi:Phkg1(display_short)|uniprotkb:Phkg(gene name synonym)|uniprotkb:Phosphorylase kinase subunit gamma-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PHKG1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000026617(transcript)|go:"GO:0004689"(phosphorylase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR002291(Phosphorylase kinase, gamma catalytic subunit)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P07934|reactome:R-MMU-70221|ensembl:ENSMUSG00000025537(gene)|refseq:NP_035209.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:oWhiqhcqtIelRPU5Z0TI4T9lskc10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P56942	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26450331|ensembl:ENSMUSP00000044352|uniprotkb:Q9D220	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mch_mouse(display_long)|uniprotkb:Pmch(gene name)|psi-mi:Pmch(display_short)|uniprotkb:Mch(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000048621(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007631"(feeding behavior)|go:"GO:0009409"(response to cold)|go:"GO:0030354"(melanin-concentrating hormone activity)|go:"GO:0031777"(type 1 melanin-concentrating hormone receptor binding)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042756"(drinking behavior)|go:"GO:0045202"(synapse)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046005"(positive regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|interpro:IPR005456(Pre-pro melanin-concentrating hormone)|mint:P56942|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUSG00000035383(gene)|refseq:NP_084247.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:l3UbZeUaSJTBhc0jao6eg+D8Q4U10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P39087	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-396914|uniprotkb:Q60933|ensembl:ENSMUSP00000101124|ensembl:ENSMUSP00000151921	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:grik2_mouse(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym)|uniprotkb:Glutamate receptor beta-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_017169293.1|ensembl:ENSMUSG00000056073(gene)|ensembl:ENSMUST00000105484(transcript)|ensembl:ENSMUST00000218823(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|mint:P39087|reactome:R-MMU-451307|reactome:R-MMU-451308	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:6sgY8SzX07HzilLLeDg3pV+sXkc10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TSH2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-911437|ensembl:ENSMUSP00000050788	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kpbb_mouse(display_long)|uniprotkb:Phkb(gene name)|psi-mi:Phkb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_955517.1|ensembl:ENSMUSG00000036879(gene)|ensembl:ENSMUST00000053771(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|interpro:IPR008734(Phosphorylase kinase alphabeta)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR011613(Glycoside hydrolase 15-related)|mint:Q7TSH2|reactome:R-MMU-70221|refseq:XP_006530595.1|refseq:XP_006530596.1|refseq:XP_006530597.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:qRovReuecws5KcJl6XVcnVO5FW410090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CC12	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470848|ensembl:ENSMUSP00000106329|uniprotkb:A2AW10|uniprotkb:Q149P8|uniprotkb:Q3U032	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cdan1_mouse(display_long)|uniprotkb:Cdan1(gene name)|psi-mi:Cdan1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000027284(gene)|ensembl:ENSMUST00000110701(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0008104"(protein localization)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031497"(chromatin assembly)|interpro:IPR028171|interpro:IPR040031|mint:Q8CC12|refseq:NP_081167.2	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:5Nyg/Fnh9WKYy3DFp/o8OTH4LGA10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P18826	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470825|ensembl:ENSMUSP00000061991|uniprotkb:A2AI90	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kpb1_mouse(display_long)|uniprotkb:Phka1(gene name)|psi-mi:Phka1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000034055(gene)|ensembl:ENSMUST00000052012(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR008734(Phosphorylase kinase alphabeta)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR011613(Glycoside hydrolase 15-related)|interpro:IPR012341(Six-hairpin glycosidase)|mint:P18826|reactome:R-MMU-70221|refseq:NP_032858.2	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:m6KkLpQv72gScTWLDJ2f1g4mtuo10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q64105	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470795|uniprotkb:Q63996	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:spre_mouse(display_long)|uniprotkb:Spr(gene name)|psi-mi:Spr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0004757"(sepiapterin reductase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006558"(L-phenylalanine metabolic process)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0010033"(response to organic substance)|go:"GO:0019889"(pteridine metabolic process)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046146"(tetrahydrobiopterin metabolic process)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050882"(voluntary musculoskeletal movement)|rcsb pdb:1NAS|rcsb pdb:1OAA|rcsb pdb:1SEP|reactome:R-MMU-1474151|reactome:R-MMU-203615|mint:Q64105|interpro:IPR036291|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR006393(Sepiapterin reductase)	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Y4ePCWcq2RI0t59kgHibLyHd6yM10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9Z1X4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6260790|ensembl:ENSMUSP00000065770|uniprotkb:Q8BP80|uniprotkb:Q8K588|uniprotkb:Q8C2H8|uniprotkb:Q812A1|uniprotkb:Q80VD5	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ilf3_mouse(display_long)|uniprotkb:Ilf3(gene name)|psi-mi:Ilf3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001264250.1|ensembl:ENSMUSG00000032178(gene)|ensembl:ENSMUST00000067646(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006479"(protein methylation)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR033099|interpro:IPR043519|mint:Q9Z1X4|rcsb pdb:4AT7|rcsb pdb:4AT8|rcsb pdb:4AT9|rcsb pdb:4ATB|rcsb pdb:5DV7|refseq:XP_006510094.1|refseq:NP_001036172.1|refseq:NP_001036173.1|refseq:NP_034691.2|refseq:NP_001264251.1	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:vxZan3L6NAseX1Ib9Z7MQ82CM3E10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6ZPR4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16728165|ensembl:ENSMUSP00000109809|uniprotkb:B2RUK3|uniprotkb:Q8C3E7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kcnt1_mouse(display_long)|uniprotkb:Kcnt1(gene name)|psi-mi:Kcnt1(display_short)|uniprotkb:Kiaa1422(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000058740(gene)|ensembl:ENSMUST00000114172(transcript)|go:"GO:0005228"(intracellular sodium activated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR013099(Ion transport 2)|mint:Q6ZPR4|refseq:NP_001289280.1|refseq:NP_780671.2	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:dqty8xDH9pIQhzgbYTeSOo4tLjA10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O35099	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-777493|uniprotkb:Q14AY5|ensembl:ENSMUSP00000093485	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:m3k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:Map3k5(gene name)|psi-mi:Map3k5(display_short)|uniprotkb:Ask1(gene name synonym)|uniprotkb:Mekk5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_032606.4|dip:DIP-38055N|ensembl:ENSMUSG00000071369(gene)|ensembl:ENSMUST00000095806(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010941"(regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902170"(cellular response to reactive nitrogen species)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:O35099|reactome:R-MMU-2559580	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:i1P8YtUNmpFauFUVVxzsMYoQYOw10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q08460	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471532|imex:IM-28526-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	-	-	-	figure legend:ST2|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rigid:ToOunnfqN/qYaNUgQRJgH2ZOHYw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8VDD9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-1369766|uniprotkb:Q9ESL6|uniprotkb:Q3TS96|uniprotkb:Q80VI6|uniprotkb:Q9EPY1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:phip_mouse(display_long)|uniprotkb:Phip1(gene name synonym)|uniprotkb:Phip(gene name)|psi-mi:Phip(display_short)|uniprotkb:Wdr11(gene name synonym)|uniprotkb:Ndrp(gene name synonym)|uniprotkb:IRS-1 PH domain-binding protein(gene name synonym)|uniprotkb:WD repeat-containing protein 11(gene name synonym)|uniprotkb:Neuronal differentiation-related protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|interpro:IPR028738|interpro:IPR036322|interpro:IPR036427|mint:Q8VDD9|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0040008"(regulation of growth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|reactome:R-MMU-9013418	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Q3tjNzPTobuShNidgEYMDlV04s010090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P48722	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8314699|ensembl:ENSMUSP00000145468|uniprotkb:Q91X29|intact:MINT-4098038|uniprotkb:P97854|uniprotkb:Q8BQD0|uniprotkb:Q3TQN2|uniprotkb:Q8CC45|uniprotkb:Q3UNG4	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:hs74l_mouse(display_long)|uniprotkb:Hspa4l(gene name)|psi-mi:Hspa4l(display_short)|uniprotkb:Apg1(gene name synonym)|uniprotkb:Hsp4l(gene name synonym)|uniprotkb:Osp94(gene name synonym)|uniprotkb:Osmotic stress protein 94(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000025757(gene)|ensembl:ENSMUST00000204702(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042708|interpro:IPR043129|mint:P48722|reactome:R-MMU-3371453|refseq:XP_006500829.2|refseq:NP_035150.3|refseq:XP_006500830.1	-	-	comment:mint|function:Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:6woBxNys6oLJnLJERYXaeuymJvw10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CPT5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8387401|intact:MINT-4124681|uniprotkb:Q921K0|uniprotkb:Q8C2P2|ensembl:ENSMUSP00000026987	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nop16_mouse(display_long)|uniprotkb:Nop16(gene name)|psi-mi:Nop16(display_short)|uniprotkb:D13Wsu177e(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_848720.1|ensembl:ENSMUST00000026987(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR019002|mint:Q9CPT5|ensembl:ENSMUSG00000025869(gene)	-	-	comment:mint	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ZLP/J+AN+CXIUpCUOY6vDdYXEbQ10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TQK1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8412090|uniprotkb:Q8C3A9|uniprotkb:Q8C3N6|intact:MINT-4114246|uniprotkb:Q8C3N4	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:int7_mouse(display_long)|uniprotkb:Ints7(gene name)|psi-mi:Ints7(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001293132.1|refseq:NP_001293133.1|interpro:IPR033060|refseq:NP_848747.4|interpro:IPR016024(Armadillo-type fold)|mint:Q7TQK1|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0016180"(snRNA processing)|go:"GO:0016604"(nuclear body)|go:"GO:0032039"(integrator complex)|go:"GO:0034472"(snRNA 3'-end processing)|go:"GO:0071479"(cellular response to ionizing radiation)|reactome:R-MMU-6807505|interpro:IPR011989(Armadillo-like helical)	-	-	function:"Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes"|comment:mint	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:HJl6gF43DZNhyFJKoOy3D8pP+wk10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:B2RR83	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8572369|ensembl:ENSMUSP00000048340|intact:MINT-8174232	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ytdc2_mouse(display_long)|uniprotkb:Keen to exit meiosis leaving testes under-populated protein(gene name synonym)|uniprotkb:YTH domain-containing protein C2(gene name synonym)|uniprotkb:Ythdc2(gene name)|psi-mi:Ythdc2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR007275(YT521-B-like protein)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031083|interpro:IPR034083|interpro:IPR036770|interpro:IPR036867|mint:B2RR83|ensembl:ENSMUSG00000034653(gene)|ensembl:ENSMUST00000037763(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007286"(spermatid development)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048599"(oocyte development)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR001374(Single-stranded nucleic acid binding R3H)|refseq:NP_001156485.1	-	-	comment:mint	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:TxNENB71AFsznI6fFqBPUX8pgdA10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q62446	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8313562|ensembl:ENSMUSP00000021332|intact:MINT-1870257|uniprotkb:Q9WTJ7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:fkbp3_mouse(display_long)|uniprotkb:Fkbp3(gene name)|psi-mi:Fkbp3(display_short)|uniprotkb:Fkbp25(gene name synonym)|uniprotkb:Rapamycin-selective 25 kDa immunophilin(gene name synonym)|uniprotkb:FK506-binding protein 3(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:Immunophilin FKBP25(gene name synonym)|uniprotkb:25 kDa FK506-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000020949(gene)|ensembl:ENSMUST00000021332(transcript)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR041200|interpro:IPR043368|mint:Q62446|rcsb pdb:3KZ7|refseq:NP_038930.1	-	-	comment:mint|function:"FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins"	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:wt3DD/Qq1QKgSonbFZ0jriqsZxk10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P50580	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-7550171|intact:MINT-1857756|ensembl:ENSMUSP00000026425|ensembl:ENSMUSP00000114434	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:pa2g4_mouse(display_long)|uniprotkb:Ebp1(gene name synonym)|uniprotkb:Pa2g4(gene name)|psi-mi:Pa2g4(display_short)|uniprotkb:Plfap(gene name synonym)|uniprotkb:Proliferation-associated protein 1(gene name synonym)|uniprotkb:Protein p38-2G4(gene name synonym)|uniprotkb:Mpp1(gene name synonym)|uniprotkb:IRES-specific cellular trans-acting factor 45 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035249.1|ensembl:ENSMUSG00000025364(gene)|ensembl:ENSMUST00000026425(transcript)|ensembl:ENSMUST00000131728(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0006417"(regulation of translation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000994(Peptidase M24, catalytic core)|interpro:IPR004545(Proliferation-associated protein 1)|interpro:IPR018349|interpro:IPR036005|interpro:IPR036388|interpro:IPR036390|mint:P50580|rcsb pdb:2V6C|rcsb pdb:6SWA|reactome:R-MMU-6798695	-	-	comment:mint|function:"May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly (By similarity). Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). Together with PTBP1 is required for the translation initiation on the foot-and-mouth disease virus (FMDV) IRES"	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:00qNeBIV6MQIU5EgEQI6zWdyPJ010090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8R1Q8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8314868|ensembl:ENSMUSP00000035366|intact:MINT-4118631	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dc1l1_mouse(display_long)|uniprotkb:Dync1li1(gene name)|psi-mi:Dync1li1(display_short)|uniprotkb:Dncli1(gene name synonym)|uniprotkb:Dnclic1(gene name synonym)|uniprotkb:Dynein light intermediate chain 1, cytosolic(gene name synonym)|uniprotkb:Dynein light chain A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000032435(gene)|ensembl:ENSMUST00000047404(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007049"(cell cycle)|go:"GO:0019003"(GDP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045504"(dynein heavy chain binding)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0051301"(cell division)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR008467(Dynein light intermediate chain)|interpro:IPR022780|interpro:IPR027417|mint:Q8R1Q8|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3371497|reactome:R-MMU-5663220|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-9646399|reactome:R-MMU-9648025|refseq:NP_666341.1	-	-	function:May play a role in binding dynein to membranous organelles or chromosomes. May associate with the heavy chains in the dynein head where they might regulate enzyme activity|comment:mint	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:aAQ4kBil3eYqmqS/J6QhMDA6a4410090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8N7N5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8392331|uniprotkb:Q8CII7|intact:MINT-4118058|uniprotkb:Q8CIK6|ensembl:ENSMUSP00000073778|ensembl:ENSMUSP00000141731|ensembl:ENSMUSP00000141732	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dcaf8_mouse(display_long)|uniprotkb:D1Ucla4(gene name synonym)|uniprotkb:H326(gene name synonym)|uniprotkb:Dcaf8(gene name)|psi-mi:Dcaf8(display_short)|uniprotkb:Wdr42a(gene name synonym)|uniprotkb:WD repeat-containing protein 42A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_011237191.1|refseq:NP_705783.1|refseq:XP_006497128.1|ensembl:ENSMUSG00000026554(gene)|ensembl:ENSMUST00000074144(transcript)|ensembl:ENSMUST00000191689(transcript)|ensembl:ENSMUST00000192704(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:Q8N7N5|reactome:R-MMU-8951664	-	-	comment:mint	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:6bs5FOYz3K84ojybQs6HGQQ+zqA10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q569Z5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8372791|uniprotkb:Q6ZQ42|uniprotkb:Q8R0R6|intact:MINT-4118429|ensembl:ENSMUSP00000133245|ensembl:ENSMUSP00000153328	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ddx46_mouse(display_long)|uniprotkb:Ddx46(gene name)|psi-mi:Ddx46(display_short)|uniprotkb:Kiaa0801(gene name synonym)|uniprotkb:DEAD box protein 46(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001268984.1|ensembl:ENSMUSG00000021500(gene)|ensembl:ENSMUST00000172272(transcript)|ensembl:ENSMUST00000223736(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q569Z5|reactome:R-MMU-72163	-	-	comment:mint|function:Plays an essential role in splicing, either prior to, or during A complex formation	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:bR28iB8YRYIjcWqTcPYs+dSC6Go10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3UHH1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8419341|uniprotkb:Q8CE12|uniprotkb:Q8CHC3|intact:MINT-4115901|uniprotkb:Q9D789|uniprotkb:Q80Y41|uniprotkb:Q5U4B9|uniprotkb:Q6PCY6|uniprotkb:B2RX90|ensembl:ENSMUSP00000022358	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:zswm8_mouse(display_long)|uniprotkb:Zswim8(gene name)|psi-mi:Zswim8(display_short)|uniprotkb:Kiaa0913(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001239010.1|refseq:NP_001239011.1|refseq:NP_082272.1|ensembl:ENSMUSG00000021819(gene)|ensembl:ENSMUST00000022358(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000627"(positive regulation of miRNA catabolic process)|interpro:IPR007527(Zinc finger, SWIM-type)|mint:Q3UHH1	-	-	comment:mint	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:C5V4tZMPbr+6VWuzv3N9p7BzPfw10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3TIX9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8328548|uniprotkb:Q8BLI5|uniprotkb:Q9CQR1|uniprotkb:Q8BZZ5|intact:MINT-4113699|uniprotkb:Q3TI55|ensembl:ENSMUSP00000064515	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:snut2_mouse(display_long)|uniprotkb:Usp39(gene name)|psi-mi:Usp39(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_613058.1|ensembl:ENSMUSG00000056305(gene)|ensembl:ENSMUST00000070345(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|mint:Q3TIX9|reactome:R-MMU-72163	-	-	comment:mint|function:"May play a role in mRNA splicing. It is unsure if the protein really exhibits hydrolase activity. Could be a competitor of ubiquitin C-terminal hydrolases (UCHs)"	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Wslfw2+ESrvoQNHZYIduTFA1Q3Y10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q91WM1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8339684|intact:MINT-4121401|uniprotkb:Q62262|ensembl:ENSMUSP00000028279|ensembl:ENSMUSP00000072047	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:strbp_mouse(display_long)|uniprotkb:Strbp(gene name)|psi-mi:Strbp(display_short)|uniprotkb:Spnr(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_011237348.1|refseq:XP_011237349.1|refseq:NP_033287.2|refseq:XP_017172309.1|refseq:XP_017172310.1|refseq:XP_017172311.1|refseq:XP_017172312.1|ensembl:ENSMUSG00000026915(gene)|ensembl:ENSMUST00000028279(transcript)|ensembl:ENSMUST00000072186(transcript)|go:"GO:0002177"(manchette)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0007638"(mechanosensory behavior)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR030446|interpro:IPR043519|interpro:IPR044472|mint:Q91WM1	-	-	comment:mint|function:"Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth (By similarity). Binds to double-stranded DNA and RNA (By similarity). Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA (By similarity). Binds also to single-stranded poly(G) RNA (By similarity). Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA"	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:+sf/OyoCMvzDmHmCmq4Me4jWjco10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99J85	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8311244|intact:MINT-4104086	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nptxr_mouse(display_long)|uniprotkb:Nptxr(gene name)|psi-mi:Nptxr(display_short)|uniprotkb:Npr(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0008029"(pentraxin receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099150"(regulation of postsynaptic specialization assembly)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR030476|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|mint:Q99J85	-	-	comment:mint	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:AWabDfkkTcL+AMgJlRt5ntbJ5WU10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6PCM2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8387212|uniprotkb:Q6PDL7|uniprotkb:Q8BQZ7|uniprotkb:Q3TA02|intact:MINT-4109478|uniprotkb:Q61204|ensembl:ENSMUSP00000086788|ensembl:ENSMUSP00000152954	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:int6_mouse(display_long)|uniprotkb:Ints6(gene name)|psi-mi:Ints6(display_short)|uniprotkb:Dbi1(gene name synonym)|uniprotkb:Ddx26(gene name synonym)|uniprotkb:DBI-1(gene name synonym)|uniprotkb:Protein DDX26(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_011243288.1|refseq:NP_032741.2|refseq:XP_006518745.1|refseq:XP_017171398.1|ensembl:ENSMUSG00000035161(gene)|ensembl:ENSMUST00000053959(transcript)|ensembl:ENSMUST00000223585(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0034472"(snRNA 3'-end processing)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR029307|interpro:IPR036465|mint:Q6PCM2|reactome:R-MMU-6807505	-	-	function:"Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes"|comment:mint	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:XqEU1yfAl7X6mwThsH+/iDa/b4g10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8VH51	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-644098|uniprotkb:Q5RJI0|uniprotkb:Q99KV0|ensembl:ENSMUSP00000105216	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rbm39_mouse(display_long)|uniprotkb:RNA-binding motif protein 39(gene name synonym)|uniprotkb:RNA-binding region-containing protein 2(gene name synonym)|uniprotkb:Coactivator of activating protein 1 and estrogen receptors(gene name synonym)|uniprotkb:Rbm39(gene name)|psi-mi:Rbm39(display_short)|uniprotkb:Caper(gene name synonym)|uniprotkb:Rnpc2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_573505.2|ensembl:ENSMUSG00000027620(gene)|ensembl:ENSMUST00000109587(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016607"(nuclear speck)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050733"(RS domain binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006509(Splicing factor, CC1-like)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR029123|interpro:IPR035979|mint:Q8VH51|rcsb pdb:2LQ5|rcsb pdb:3S6E|rcsb pdb:4J5O|rcsb pdb:4RU2|rcsb pdb:5CXT|refseq:XP_011237629.1|refseq:NP_001278043.1|refseq:NP_001278044.1|refseq:XP_017171483.1|refseq:XP_017171494.1|refseq:XP_017171497.1|refseq:XP_011237628.1|refseq:XP_017171487.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:dW5PuXllczFeyQ6ask6CFrukMKk10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P70372	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6877056|ensembl:ENSMUSP00000096549|ensembl:ENSMUSP00000146866|uniprotkb:Q60745|uniprotkb:Q78QY3	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:elav1_mouse(display_long)|uniprotkb:Elavl1(gene name)|psi-mi:Elavl1(display_short)|uniprotkb:Elra(gene name synonym)|uniprotkb:Hua(gene name synonym)|uniprotkb:Elav-like generic protein(gene name synonym)|uniprotkb:Hu-antigen R(gene name synonym)|uniprotkb:MelG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000040028(gene)|ensembl:ENSMUST00000098950(transcript)|ensembl:ENSMUST00000209010(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035198"(miRNA binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034996|interpro:IPR035979|mint:P70372|reactome:R-MMU-450520|reactome:R-MMU-72163|go:"GO:0019901"(protein kinase binding)|refseq:XP_006508761.1|refseq:NP_034615.2|dip:DIP-46480N	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:iKHrpZqi5b7EFLkfVJSRTpi9sj010090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P62075	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6273235|ensembl:ENSMUSP00000020440|uniprotkb:Q91VM6|uniprotkb:Q9DC89|uniprotkb:Q9UHL8|uniprotkb:Q9WTL1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tim13_mouse(display_long)|uniprotkb:Timm13(gene name)|psi-mi:Timm13(display_short)|uniprotkb:Tim13a(gene name synonym)|uniprotkb:Timm13a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000020219(gene)|ensembl:ENSMUST00000020440(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR039238|mint:P62075|interpro:IPR035427|refseq:NP_038923.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:R/vnkTj18yj02tVgUfU8liFhT8A10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:A2RSY6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471734|uniprotkb:Q0VGB9|uniprotkb:Q3UFG1|uniprotkb:Q3UKB0|uniprotkb:Q8C2S4|uniprotkb:Q8CI50|uniprotkb:Q8R203|uniprotkb:Q9CT68	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:trm1l_mouse(display_long)|uniprotkb:Trmt1l(gene name)|psi-mi:Trmt1l(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0000049"(tRNA binding)|go:"GO:0002940"(tRNA N2-guanine methylation)|go:"GO:0004809"("tRNA (guanine-N2-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0030534"(adult behavior)|go:"GO:0046872"(metal ion binding)|mint:A2RSY6|refseq:NP_081152.2|interpro:IPR029063|interpro:IPR002905(N2,N2-dimethylguanosine tRNA methyltransferase)|interpro:IPR042296|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:kZky6wGrlfi/HQFN9ZEkxXltNt010090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8BS45	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-22226773|ensembl:ENSMUSP00000124369	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ift56_mouse(display_long)|uniprotkb:Ttc26(gene name)|psi-mi:Ttc26(display_short)|uniprotkb:Hop(gene name synonym)|uniprotkb:Ift56(gene name synonym)|uniprotkb:Protein hop-sterile(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 26(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000056832(gene)|ensembl:ENSMUST00000162554(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007286"(spermatid development)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0015031"(protein transport)|go:"GO:0030992"(intraciliary transport particle B)|go:"GO:0035082"(axoneme assembly)|go:"GO:0035720"(intraciliary anterograde transport)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0097546"(ciliary base)|go:"GO:0120170"(intraciliary transport particle B binding)|go:"GO:1905198"(manchette assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR030511|mint:Q8BS45|reactome:R-MMU-5620924|refseq:NP_705828.2	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:p2KI2cBHfmwpd4dDL9zp84Jvvo410090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:E9PYL2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471717|ensembl:ENSMUSP00000054702|uniprotkb:Q69ZN8	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:prr12_mouse(display_long)|uniprotkb:Prr12(gene name)|psi-mi:Prr12(display_short)|uniprotkb:Kiaa1205(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000046574(gene)|ensembl:ENSMUST00000057293(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043005"(neuron projection)|interpro:IPR025451|mint:E9PYL2|refseq:NP_778187.2	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:mcVNqEufsCPTmvagjHEVyG/a8Vw10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9JKF1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-644633|ensembl:ENSMUSP00000128278|uniprotkb:G3UW45	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:iqga1_mouse(display_long)|uniprotkb:Iqgap1(gene name)|psi-mi:Iqgap1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|ensembl:ENSMUSG00000030536(gene)|ensembl:ENSMUST00000167377(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010761"(fibroblast migration)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035305"(negative regulation of dephosphorylation)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0031252"(cell leading edge)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:Q9JKF1|reactome:R-MMU-373753|reactome:R-MMU-5626467|reactome:R-MMU-5674135|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013106|reactome:R-MMU-9013148|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-MMU-9013149|refseq:NP_057930.2|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013424	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:qjWT+er4GkLOlebk3zzRHh2Iqoo10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6ZPJ0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471694|ensembl:ENSMUSP00000041985|uniprotkb:B1ATR1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tex2_mouse(display_long)|uniprotkb:Tex2(gene name)|psi-mi:Tex2(display_short)|uniprotkb:Kiaa1738(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000040548(gene)|ensembl:ENSMUST00000042780(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006869"(lipid transport)|go:"GO:0008289"(lipid binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|interpro:IPR031468|mint:Q6ZPJ0|reactome:R-MMU-8980692|refseq:NP_938034.2|refseq:XP_006533206.1|refseq:XP_006533207.1|refseq:XP_006533208.1|refseq:XP_006533209.1|refseq:XP_006533210.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:MRA2LQCdDWcxObn5NV4hMLiac3810090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9D6N5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471393|ensembl:ENSMUSP00000025853	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nc2a_mouse(display_long)|uniprotkb:Drap1(gene name)|psi-mi:Drap1(display_short)|uniprotkb:Dr1-associated protein 1(gene name synonym)|uniprotkb:Negative cofactor 2-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000024914(gene)|ensembl:ENSMUST00000025853(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR003958(Transcription factor CBF/NF-Y/archaeal histone)|interpro:IPR009072(Histone-fold)|mint:Q9D6N5|reactome:R-MMU-1181150|reactome:R-MMU-1502540|go:"GO:0017054"(negative cofactor 2 complex)|refseq:NP_001278009.1|refseq:NP_077138.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:trjtIziCyfxcms8fw3QoTp7pWgA10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3UFQ8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-13951462|ensembl:ENSMUSP00000075587|uniprotkb:Q6KAP3	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:carl3_mouse(display_long)|uniprotkb:Carmil3(gene name)|psi-mi:Carmil3(display_short)|uniprotkb:Lrrc16b(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker protein 3(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000022211(gene)|ensembl:ENSMUST00000076236(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029766|interpro:IPR031943|interpro:IPR032675|interpro:IPR041245|mint:Q3UFQ8|refseq:NP_001019816.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:gPESbxfNq/mOFgUYRM0Yw83jUYk10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q04690	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-397326|uniprotkb:Q61956|uniprotkb:Q61957|ensembl:ENSMUSP00000071289	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nf1_mouse(display_long)|uniprotkb:Nf1(gene name)|psi-mi:Nf1(display_short)|uniprotkb:Neurofibromatosis-related protein NF-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035027.1|refseq:XP_006532504.1|go:"GO:0007420"(brain development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0008542"(visual learning)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0021510"(spinal cord development)|go:"GO:0021764"(amygdala development)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0021915"(neural tube development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0045685"(regulation of glial cell differentiation)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023152|interpro:IPR036865|interpro:IPR039360|mint:Q04690|go:"GO:0030424"(axon)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035021"(negative regulation of Rac protein signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043473"(pigmentation)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045545"(syndecan binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|ensembl:ENSMUSG00000020716(gene)|ensembl:ENSMUST00000071325(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001656"(metanephros development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001889"(liver development)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007154"(cell communication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|reactome:R-MMU-5658442	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:aegHzgNy813/APoCjeM166e+MFE10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O88532	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-645485|uniprotkb:Q3TY30|uniprotkb:Q8BS85|uniprotkb:Q8CGG5|uniprotkb:Q91VZ0|uniprotkb:Q9CT34|ensembl:ENSMUSP00000118911	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:zfr_mouse(display_long)|uniprotkb:Zfr(gene name)|psi-mi:Zfr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035897.2|ensembl:ENSMUSG00000022201(gene)|ensembl:ENSMUST00000122941(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR006561(DZF)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043519|mint:O88532	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ncNwFUEUk0r2XotuXm/9Tt4iB5w10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q5DU41	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471671|ensembl:ENSMUSP00000108327|uniprotkb:B2RSI6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:lrc8b_mouse(display_long)|uniprotkb:Lrrc8b(gene name)|psi-mi:Lrrc8b(display_short)|uniprotkb:Kiaa0231(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 8B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000070639(gene)|ensembl:ENSMUST00000112707(transcript)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0034702"(ion channel complex)|go:"GO:0098656"(anion transmembrane transport)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR021040|interpro:IPR032675|mint:Q5DU41|reactome:R-MMU-5223345|refseq:NP_001028722.1|refseq:XP_011247810.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:pIaVtAr+oH3iytnXJ5lubI8K0XY10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q62443	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470897|ensembl:ENSMUSP00000026670	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nptx1_mouse(display_long)|uniprotkb:Nptx1(gene name)|psi-mi:Nptx1(display_short)|uniprotkb:Neuronal pentraxin I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000025582(gene)|ensembl:ENSMUST00000026670(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0030133"(transport vesicle)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|mint:Q62443|refseq:NP_032756.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ddE8h5JD7XtrGle7yD9q+E4m/co10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q07235	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471220|ensembl:ENSMUSP00000027467|uniprotkb:Q921T7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:gdn_mouse(display_long)|uniprotkb:Serpine2(gene name)|psi-mi:Serpine2(display_short)|uniprotkb:Pi7(gene name synonym)|uniprotkb:Pn1(gene name synonym)|uniprotkb:Spi4(gene name synonym)|uniprotkb:Peptidase inhibitor 7(gene name synonym)|uniprotkb:Protease nexin 1(gene name synonym)|uniprotkb:Protease nexin I(gene name synonym)|uniprotkb:Serine protease-inhibitor 4(gene name synonym)|uniprotkb:Serpin E2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0021683"(cerebellar granular layer morphogenesis)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032940"(secretion by cell)|go:"GO:0033363"(secretory granule organization)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042628"(mating plug formation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0061108"(seminal vesicle epithelium development)|go:"GO:0061110"(dense core granule biogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090331"(negative regulation of platelet aggregation)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:Q07235|reactome:R-MMU-140837|reactome:R-MMU-140875|reactome:R-MMU-75205|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010757"(negative regulation of plasminogen activation)|ensembl:ENSMUSG00000026249(gene)|ensembl:ENSMUST00000027467(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|refseq:NP_033281.1|refseq:XP_006496522.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:f5t+yFZxEMpxZwjoEoJGYUWxq+410090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:A2A7S8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471648|ensembl:ENSMUSP00000101666|uniprotkb:A2A7S9|uniprotkb:Q3U356|uniprotkb:Q3U437|uniprotkb:Q3V3N0|uniprotkb:Q6ZPN9|uniprotkb:Q8K0K8	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:k1522_mouse(display_long)|uniprotkb:Kiaa1522(gene name)|psi-mi:Kiaa1522(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000050390(gene)|ensembl:ENSMUST00000106051(transcript)|go:"GO:0030154"(cell differentiation)|mint:A2A7S8|refseq:NP_001028361.1|refseq:NP_001272794.1|refseq:NP_001272795.1|refseq:NP_001272796.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:yjKiCH0Alsbl/Mv30kdyh7r3N/Q10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q63918	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-529937|uniprotkb:Q3V1P6|uniprotkb:Q78EC3|uniprotkb:Q8CBT4|ensembl:ENSMUSP00000055694	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cavn2_mouse(display_long)|uniprotkb:Cavin2(gene name)|psi-mi:Cavin2(display_short)|uniprotkb:Cavin-2(gene name synonym)|uniprotkb:Phosphatidylserine-binding protein(gene name synonym)|uniprotkb:Sdpr(gene name synonym)|uniprotkb:Sdr(gene name synonym)|uniprotkb:Serum deprivation-response protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_620080.1|ensembl:ENSMUSG00000045954(gene)|ensembl:ENSMUST00000051572(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR026752|interpro:IPR033298|mint:Q63918	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:B2xqFslEZ88bjzfVfLbj3T6lYhA10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O08749	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-773199|uniprotkb:Q3TG55|uniprotkb:Q3U5W5|uniprotkb:Q3UWP7|uniprotkb:Q99LD3|ensembl:ENSMUSP00000106481	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dldh_mouse(display_long)|uniprotkb:Dihydrolipoamide dehydrogenase(gene name synonym)|uniprotkb:Dld(gene name)|psi-mi:Dld(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_031887.2|ensembl:ENSMUSG00000020664(gene)|ensembl:ENSMUST00000110857(transcript)|go:"GO:0004148"(dihydrolipoyl dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005929"(cilium)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006508"(proteolysis)|go:"GO:0007369"(gastrulation)|go:"GO:0007568"(aging)|go:"GO:0009106"(lipoate metabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0034604"("pyruvate dehydrogenase (NAD+) activity")|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043159"(acrosomal matrix)|go:"GO:0043209"(myelin sheath)|go:"GO:0043544"(lipoamide binding)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0051068"(dihydrolipoamide metabolic process)|go:"GO:0051287"(NAD binding)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0106077"(histone succinylation)|interpro:IPR001100(Pyridine nucleotide-disulphide oxidoreductase, class I)|interpro:IPR004099(Pyridine nucleotide-disulphide oxidoreductase, dimerisation)|interpro:IPR006258(Dihydrolipoamide dehydrogenase)|interpro:IPR012999(Pyridine nucleotide-disulphide oxidoreductase, class I, active site)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR036188|mint:O08749|reactome:R-MMU-204174|reactome:R-MMU-389661|reactome:R-MMU-5362517|reactome:R-MMU-6783984|reactome:R-MMU-70268|reactome:R-MMU-70895|reactome:R-MMU-71064|reactome:R-MMU-71403	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:6j/8rw4lkNMW4Lo5sGoRdDJBk2w10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80TR4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470923|ensembl:ENSMUSP00000025993|uniprotkb:Q9WVB5	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:slit1_mouse(display_long)|uniprotkb:Slit1(gene name)|psi-mi:Slit1(display_short)|uniprotkb:Kiaa0813(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000025993(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007097"(nuclear migration)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051964"(negative regulation of synapse assembly)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR006207(Cystine knot, C-terminal)|ensembl:ENSMUSG00000025020(gene)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|interpro:IPR032675|mint:Q80TR4|refseq:NP_056563.2|refseq:XP_011245502.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:8SeUazCGHiowSI+ACP8ezeOC8pg10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6P6N5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-9094545|uniprotkb:Q7TNJ8	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:spre3_mouse(display_long)|uniprotkb:Spred3(gene name)|psi-mi:Spred3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR041937|mint:Q6P6N5|refseq:NP_891557.3|interpro:IPR023337|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR007875(Sprouty)|interpro:IPR000697(EVH1)|refseq:XP_006539516.1|refseq:XP_006539517.1|refseq:XP_006539518.1|refseq:XP_006539519.1|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902747"(negative regulation of lens fiber cell differentiation)|reactome:R-MMU-5658442	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:NXhyQ64E96hrWm5caGb1ezdw8Vk10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9D6G9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470970|ensembl:ENSMUSP00000036138|uniprotkb:Q9DB66	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cklf5_mouse(display_long)|uniprotkb:Cmtm5(gene name)|psi-mi:Cmtm5(display_short)|uniprotkb:Cklfsf5(gene name synonym)|uniprotkb:Chemokine-like factor superfamily member 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000040759(gene)|ensembl:ENSMUST00000037814(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045662"(negative regulation of myoblast differentiation)|interpro:IPR008253(Marvel)|mint:Q9D6G9|refseq:NP_080342.1|refseq:XP_017171651.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Kj8DRGtMwsoKRnanvRkfzDr+4J810090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8BK63	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-771679|uniprotkb:Q64506|uniprotkb:Q80XI2|uniprotkb:Q99LY3|uniprotkb:Q3UIL0|ensembl:ENSMUSP00000132083	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kc1a_mouse(display_long)|uniprotkb:CK1(gene name synonym)|uniprotkb:Csnk1a1(gene name)|psi-mi:Csnk1a1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_006526451.1|dip:DIP-32408N|ensembl:ENSMUSG00000024576(gene)|ensembl:ENSMUST00000165721(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000776"(kinetochore)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007030"(Golgi organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042277"(peptide binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q8BK63|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-4641262|reactome:R-MMU-5610785|reactome:R-MMU-5635838	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:2rG1/sMVnsRKUEWsLhLAyHvqPnY10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P46662	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-644586|uniprotkb:Q8BR03|ensembl:ENSMUSP00000105536	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:merl_mouse(display_long)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)|uniprotkb:Nf2(gene name)|psi-mi:Nf2(display_short)|uniprotkb:Nf-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035028.2|refseq:XP_006514633.1|ensembl:ENSMUSG00000009073(gene)|ensembl:ENSMUST00000109910(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007398"(ectoderm development)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030175"(filopodium)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035330"(regulation of hippo signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042127"(regulation of cell population proliferation)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P46662|rcsb pdb:1ISN|rcsb pdb:3WA0|interpro:IPR000798(Ezrin/radixin/moesin ERM)|rcsb pdb:4P7I|rcsb pdb:4ZRK|reactome:R-MMU-2029482|reactome:R-MMU-5627123|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR000299(Band 4.1, N-terminal)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|refseq:NP_001239179.1|refseq:NP_001239180.1|refseq:XP_011241971.1|refseq:NP_001239181.1|refseq:NP_001239182.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:xDzmqR+fx4dbxWKxBm5h+sWkzEw10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9DC23	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11519065|uniprotkb:A2ASA2|uniprotkb:Q71S84|uniprotkb:Q8CH78|uniprotkb:Q8CIB0|uniprotkb:Q99LV4|ensembl:ENSMUSP00000028392	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:djc10_mouse(display_long)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 5(gene name synonym)|uniprotkb:Endoplasmic reticulum DnaJ-PDI fusion protein 1(gene name synonym)|uniprotkb:J domain-containing protein disulfide isomerase-like protein(gene name synonym)|uniprotkb:Dnajc10(gene name)|psi-mi:Dnajc10(display_short)|uniprotkb:Erdj5(gene name synonym)|uniprotkb:Jpdi(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_077143.2|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR021170|interpro:IPR035673|interpro:IPR035674|interpro:IPR036249|interpro:IPR036869|mint:Q9DC23|rcsb pdb:3APO|rcsb pdb:3APQ|rcsb pdb:3APS|rcsb pdb:5AYK|rcsb pdb:5AYL|ensembl:ENSMUSG00000027006(gene)|ensembl:ENSMUST00000028392(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0016671"(oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:c0q6L2PbblPtjC87yOuzbwdDUuM10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O35681	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-457995|uniprotkb:P97791|uniprotkb:Q80WV1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:syt3_mouse(display_long)|uniprotkb:Syt3(gene name)|psi-mi:Syt3(display_short)|uniprotkb:Synaptotagmin III(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001107588.1|refseq:NP_057872.3|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR028682|mint:O35681|interpro:IPR035892	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:mkfffZn3WWGhztw/udRiKd0LUJ010090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6ZPV2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-3043902|ensembl:ENSMUSP00000051845|uniprotkb:A2AQP8|uniprotkb:Q6P7V0|uniprotkb:Q6PCP1|uniprotkb:Q8C9T7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ino80_mouse(display_long)|uniprotkb:Ino80(gene name)|psi-mi:Ino80(display_short)|uniprotkb:Inoc1(gene name synonym)|uniprotkb:Kiaa1259(gene name synonym)|uniprotkb:DNA helicase-related INO80 complex homolog 1(gene name synonym)|uniprotkb:DNA helicase-related protein INO80(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000034154(gene)|ensembl:ENSMUST00000049920(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031011"(Ino80 complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042393"(histone binding)|go:"GO:0042766"(nucleosome mobilization)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043044"|go:"GO:0043618"(regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070615"|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR020838|interpro:IPR027417|interpro:IPR031047|interpro:IPR038718|mint:Q6ZPV2|reactome:R-MMU-5689603|reactome:R-MMU-5696394|refseq:NP_080850.2	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:4TfoC8GVpirZZMPsohrCRYf8A3I10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3U4G0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470987|ensembl:ENSMUSP00000106543|uniprotkb:Q80WT3|uniprotkb:Q8C1X6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cdin1_mouse(display_long)|uniprotkb:Cdin1(gene name)|psi-mi:Cdin1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000040282(gene)|ensembl:ENSMUST00000110918(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030218"(erythrocyte differentiation)|interpro:IPR029404|mint:Q3U4G0|refseq:NP_001139370.1|refseq:NP_997147.3	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:gJ5bh/GvxiLfIKZVcJBRB/LWpzY10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9Z321	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16728364|ensembl:ENSMUSP00000023465|ensembl:ENSMUSP00000156132	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:top3b_mouse(display_long)|uniprotkb:DNA topoisomerase III beta-1(gene name synonym)|uniprotkb:Top3b(gene name)|psi-mi:Top3b(display_short)|uniprotkb:Top3b1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000022779(gene)|ensembl:ENSMUST00000023465(transcript)|ensembl:ENSMUST00000232581(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003916"(DNA topoisomerase activity)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007059"(chromosome segregation)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|mint:Q9Z321|refseq:NP_001313505.1|refseq:NP_035754.1|refseq:XP_006522054.1|refseq:XP_006522055.1|refseq:XP_006522057.1|refseq:XP_006522058.1|refseq:XP_017172426.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:9m6mpZ7aIV3fx3bU6opc3sFN3SA10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q5XJV6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16726286|uniprotkb:A6BLZ0|uniprotkb:Q52KF1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:lmtk3_mouse(display_long)|uniprotkb:Apoptosis-associated tyrosine kinase 3(gene name synonym)|uniprotkb:Lemur tyrosine kinase 3(gene name synonym)|uniprotkb:Lmtk3(gene name)|psi-mi:Lmtk3(display_short)|uniprotkb:Aatyk3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|mint:Q5XJV6|refseq:NP_001005511.2|refseq:NP_001277919.1|refseq:XP_006541027.1|refseq:XP_017177816.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:FJgk1CZB0wgIbl5dhC81Wy7TRJE10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9D6S7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471110|ensembl:ENSMUSP00000028250|uniprotkb:B1B055	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rrfm_mouse(display_long)|uniprotkb:Mrrf(gene name)|psi-mi:Mrrf(display_short)|uniprotkb:Ribosome-releasing factor, mitochondrial(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000026887(gene)|ensembl:ENSMUST00000028250(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006412"(translation)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0043023"(ribosomal large subunit binding)|interpro:IPR002661(Ribosome recycling factor)|interpro:IPR023584|interpro:IPR036191|mint:Q9D6S7|rcsb pdb:1WIH|reactome:R-MMU-5419276|refseq:NP_080698.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:IZfaK7W9vh+OKt5CBZii+juKlo810090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P07934	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470873|ensembl:ENSMUSP00000026617	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:phkg1_mouse(display_long)|uniprotkb:Phkg1(gene name)|psi-mi:Phkg1(display_short)|uniprotkb:Phkg(gene name synonym)|uniprotkb:Phosphorylase kinase subunit gamma-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PHKG1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000026617(transcript)|go:"GO:0004689"(phosphorylase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR002291(Phosphorylase kinase, gamma catalytic subunit)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P07934|reactome:R-MMU-70221|ensembl:ENSMUSG00000025537(gene)|refseq:NP_035209.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:oWhiqhcqtIelRPU5Z0TI4T9lskc10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CIE6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-644254|uniprotkb:E9Q075|ensembl:ENSMUSP00000118179	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:copa_mouse(display_long)|uniprotkb:Alpha-coat protein(gene name synonym)|uniprotkb:Copa(gene name)|psi-mi:Copa(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_034068.3|ensembl:ENSMUSG00000026553(gene)|ensembl:ENSMUST00000135192(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003729"(mRNA binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0044297"(cell body)|go:"GO:0099612"(protein localization to axon)|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR001680(WD40 repeat)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR010714(Coatomer, alpha subunit, C-terminal)|interpro:IPR011048(Cytochrome cd1-nitrite reductase-like, C-terminal haem d1)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016391(Coatomer, alpha subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|mint:Q8CIE6|rcsb pdb:5A1U|rcsb pdb:5A1V|rcsb pdb:5A1W|rcsb pdb:5A1X|rcsb pdb:5A1Y|rcsb pdb:5NZR|rcsb pdb:5NZS|rcsb pdb:5NZT|rcsb pdb:5NZU|rcsb pdb:5NZV|reactome:R-MMU-6807878|reactome:R-MMU-6811434	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:c+/zgZ1/6rEy0vlikp+E+4gijto10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:B1AY13	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-9662176|uniprotkb:Q8BLI7|ensembl:ENSMUSP00000092538	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ubp24_mouse(display_long)|uniprotkb:Usp24(gene name)|psi-mi:Usp24(display_short)|uniprotkb:Deubiquitinating enzyme 24(gene name synonym)|uniprotkb:Ubiquitin thioesterase 24(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 24(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_899048.2|ensembl:ENSMUSG00000028514(gene)|ensembl:ENSMUST00000094933(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018200|interpro:IPR021905|interpro:IPR028889|interpro:IPR029071|interpro:IPR033382|interpro:IPR038765|mint:B1AY13|reactome:R-MMU-5689880	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:piuoMxUZPd2jM/4a9+alnjXjQ0810090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CGI1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471635|ensembl:ENSMUSP00000092463|uniprotkb:Q499G1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:f193a_mouse(display_long)|uniprotkb:Fam193a(gene name)|psi-mi:Fam193a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000037210(gene)|ensembl:ENSMUST00000094867(transcript)|interpro:IPR029717|interpro:IPR029719|interpro:IPR031802|mint:Q8CGI1|refseq:NP_001230052.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:5CsKlLdvup0UEUKEmnD5Y6byI2Q10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3UIU2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2934427|ensembl:ENSMUSP00000092746	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ndub6_mouse(display_long)|uniprotkb:Ndufb6(gene name)|psi-mi:Ndufb6(display_short)|uniprotkb:Gm137(gene name synonym)|uniprotkb:Complex I-B17(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase B17 subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000071014(gene)|ensembl:ENSMUST00000095128(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|interpro:IPR019174|rcsb pdb:6G2J|rcsb pdb:6G72|rcsb pdb:6ZR2|rcsb pdb:6ZTQ|rcsb pdb:7AK5|rcsb pdb:7AK6|rcsb pdb:7B93|reactome:R-MMU-611105|reactome:R-MMU-6799198|mint:Q3UIU2|refseq:NP_001028477.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:FIprQvG6ZL1DDoxrJvYTkzz/ei810090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80X66	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471043|ensembl:ENSMUSP00000048530	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:btbda_mouse(display_long)|uniprotkb:Btbd10(gene name)|psi-mi:Btbd10(display_short)|uniprotkb:Gmrp1(gene name synonym)|uniprotkb:Glucose metabolism-related protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR011333(BTB/POZ fold)|interpro:IPR039885|interpro:IPR039886|mint:Q80X66|ensembl:ENSMUSG00000038187(gene)|ensembl:ENSMUST00000047091(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR000210(BTB/POZ-like)|refseq:NP_598461.1|refseq:XP_006508223.1|refseq:XP_011240192.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:VoTwPedMCjTuxDWUH5cbm1iIUQ410090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P56942	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26450331|ensembl:ENSMUSP00000044352|uniprotkb:Q9D220	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mch_mouse(display_long)|uniprotkb:Pmch(gene name)|psi-mi:Pmch(display_short)|uniprotkb:Mch(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000048621(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007631"(feeding behavior)|go:"GO:0009409"(response to cold)|go:"GO:0030354"(melanin-concentrating hormone activity)|go:"GO:0031777"(type 1 melanin-concentrating hormone receptor binding)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042756"(drinking behavior)|go:"GO:0045202"(synapse)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046005"(positive regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|interpro:IPR005456(Pre-pro melanin-concentrating hormone)|mint:P56942|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUSG00000035383(gene)|refseq:NP_084247.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:l3UbZeUaSJTBhc0jao6eg+D8Q4U10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P11881	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-541478|uniprotkb:P20943|uniprotkb:Q99LG5|ensembl:ENSMUSP00000032192	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:itpr1_mouse(display_long)|uniprotkb:Type 1 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 1(gene name synonym)|uniprotkb:Inositol 1,4,5-trisphosphate-binding protein P400(gene name synonym)|uniprotkb:Purkinje cell protein 1(gene name synonym)|uniprotkb:Protein PCD-6(gene name synonym)|uniprotkb:Itpr1(gene name)|psi-mi:Itpr1(display_short)|uniprotkb:Insp3r(gene name synonym)|uniprotkb:Pcd6(gene name synonym)|uniprotkb:Pcp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_034715.3|refseq:XP_006505693.1|refseq:XP_006505699.1|refseq:XP_006505700.1|dip:DIP-32243N|refseq:XP_017176897.1|refseq:XP_017176899.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0098794"(postsynapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|mint:P11881|rcsb pdb:1N4K|rcsb pdb:1XZZ|rcsb pdb:5GUG|rcsb pdb:5X9Z|rcsb pdb:5XA0|rcsb pdb:5XA1|reactome:R-MMU-114508|reactome:R-MMU-139853|reactome:R-MMU-381676|reactome:R-MMU-418457|reactome:R-MMU-5578775|reactome:R-MMU-983695|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097421"(liver regeneration)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098695"(inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels)|go:"GO:0098793"(presynapse)|ensembl:ENSMUSG00000030102(gene)|ensembl:ENSMUST00000032192(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:O+LA4/Acwos+RNtyqL3IgAe/kkk10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CCK0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-20313485|uniprotkb:A0JP36|uniprotkb:Q3TNT4|uniprotkb:Q925I6|ensembl:ENSMUSP00000020283	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:h2aw_mouse(display_long)|uniprotkb:Macroh2a2(gene name)|psi-mi:Macroh2a2(display_short)|uniprotkb:H2afy2(gene name synonym)|uniprotkb:H2afy3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_996883.1|ensembl:ENSMUSG00000020086(gene)|ensembl:ENSMUST00000020283(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001740"(Barr body)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0007420"(brain development)|go:"GO:0007549"(dosage compensation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:1901837"(negative regulation of transcription of nucleolar large rRNA by RNA polymerase I)|interpro:IPR002119(Histone H2A)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR021171|interpro:IPR032454|interpro:IPR035796|interpro:IPR043472|mint:Q8CCK0	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:VDYaQkuXNy0GqZ4NPpvUOToqdq410090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P24270	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2924912|uniprotkb:Q3TXQ6|ensembl:ENSMUSP00000028610	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cata_mouse(display_long)|uniprotkb:Cat(gene name)|psi-mi:Cat(display_short)|uniprotkb:Cas-1(gene name synonym)|uniprotkb:Cas1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0055093"(response to hyperoxia)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0080184"(response to phenylpropanoid)|interpro:IPR002226(Catalase)|interpro:IPR010582(Catalase-related)|interpro:IPR011614(Catalase, N-terminal)|interpro:IPR018028|interpro:IPR020835|interpro:IPR024708|interpro:IPR024711|interpro:IPR040333|mint:P24270|reactome:R-MMU-3299685|reactome:R-MMU-6798695|reactome:R-MMU-9033241|go:"GO:0051781"(positive regulation of cell division)|ensembl:ENSMUSG00000027187(gene)|ensembl:ENSMUST00000028610(transcript)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0004096"(catalase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009642"(response to light intensity)|go:"GO:0009650"(UV protection)|go:"GO:0010193"(response to ozone)|go:"GO:0010288"(response to lead ion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0016209"(antioxidant activity)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019899"(enzyme binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|refseq:NP_033934.2	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Ahsw8/VMIQAUw7mWuBSFRn9g/3M10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P39087	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-396914|uniprotkb:Q60933|ensembl:ENSMUSP00000101124|ensembl:ENSMUSP00000151921	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:grik2_mouse(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym)|uniprotkb:Glutamate receptor beta-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_017169293.1|ensembl:ENSMUSG00000056073(gene)|ensembl:ENSMUST00000105484(transcript)|ensembl:ENSMUST00000218823(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|mint:P39087|reactome:R-MMU-451307|reactome:R-MMU-451308	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:6sgY8SzX07HzilLLeDg3pV+sXkc10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TSH2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-911437|ensembl:ENSMUSP00000050788	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kpbb_mouse(display_long)|uniprotkb:Phkb(gene name)|psi-mi:Phkb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_955517.1|ensembl:ENSMUSG00000036879(gene)|ensembl:ENSMUST00000053771(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|interpro:IPR008734(Phosphorylase kinase alphabeta)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR011613(Glycoside hydrolase 15-related)|mint:Q7TSH2|reactome:R-MMU-70221|refseq:XP_006530595.1|refseq:XP_006530596.1|refseq:XP_006530597.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:qRovReuecws5KcJl6XVcnVO5FW410090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CC12	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470848|ensembl:ENSMUSP00000106329|uniprotkb:A2AW10|uniprotkb:Q149P8|uniprotkb:Q3U032	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cdan1_mouse(display_long)|uniprotkb:Cdan1(gene name)|psi-mi:Cdan1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000027284(gene)|ensembl:ENSMUST00000110701(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0008104"(protein localization)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031497"(chromatin assembly)|interpro:IPR028171|interpro:IPR040031|mint:Q8CC12|refseq:NP_081167.2	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:5Nyg/Fnh9WKYy3DFp/o8OTH4LGA10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P18826	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470825|ensembl:ENSMUSP00000061991|uniprotkb:A2AI90	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kpb1_mouse(display_long)|uniprotkb:Phka1(gene name)|psi-mi:Phka1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000034055(gene)|ensembl:ENSMUST00000052012(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR008734(Phosphorylase kinase alphabeta)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR011613(Glycoside hydrolase 15-related)|interpro:IPR012341(Six-hairpin glycosidase)|mint:P18826|reactome:R-MMU-70221|refseq:NP_032858.2	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:m6KkLpQv72gScTWLDJ2f1g4mtuo10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CXY6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2312782|uniprotkb:Q3U083|uniprotkb:Q5RKG0|uniprotkb:Q8CCY9|uniprotkb:Q99KS3|ensembl:ENSMUSP00000001042	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ilf2_mouse(display_long)|uniprotkb:Ilf2(gene name)|psi-mi:Ilf2(display_short)|uniprotkb:Nf45(gene name synonym)|uniprotkb:Nuclear factor of activated T-cells 45 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080650.1|ensembl:ENSMUSG00000001016(gene)|ensembl:ENSMUST00000001042(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR043519|mint:Q9CXY6|rcsb pdb:4AT7|rcsb pdb:4AT8|rcsb pdb:4AT9|rcsb pdb:4ATB|reactome:R-MMU-6798695	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:HwUDuY6Ev7csoTThxZCW8nJT88o10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q64105	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470795|uniprotkb:Q63996	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:spre_mouse(display_long)|uniprotkb:Spr(gene name)|psi-mi:Spr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0004757"(sepiapterin reductase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006558"(L-phenylalanine metabolic process)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0010033"(response to organic substance)|go:"GO:0019889"(pteridine metabolic process)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046146"(tetrahydrobiopterin metabolic process)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050882"(voluntary musculoskeletal movement)|rcsb pdb:1NAS|rcsb pdb:1OAA|rcsb pdb:1SEP|reactome:R-MMU-1474151|reactome:R-MMU-203615|mint:Q64105|interpro:IPR036291|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR006393(Sepiapterin reductase)	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Y4ePCWcq2RI0t59kgHibLyHd6yM10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9Z1X4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6260790|ensembl:ENSMUSP00000065770|uniprotkb:Q8BP80|uniprotkb:Q8K588|uniprotkb:Q8C2H8|uniprotkb:Q812A1|uniprotkb:Q80VD5	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ilf3_mouse(display_long)|uniprotkb:Ilf3(gene name)|psi-mi:Ilf3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001264250.1|ensembl:ENSMUSG00000032178(gene)|ensembl:ENSMUST00000067646(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006479"(protein methylation)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR033099|interpro:IPR043519|mint:Q9Z1X4|rcsb pdb:4AT7|rcsb pdb:4AT8|rcsb pdb:4AT9|rcsb pdb:4ATB|rcsb pdb:5DV7|refseq:XP_006510094.1|refseq:NP_001036172.1|refseq:NP_001036173.1|refseq:NP_034691.2|refseq:NP_001264251.1	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:vxZan3L6NAseX1Ib9Z7MQ82CM3E10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6ZPR4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16728165|ensembl:ENSMUSP00000109809|uniprotkb:B2RUK3|uniprotkb:Q8C3E7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kcnt1_mouse(display_long)|uniprotkb:Kcnt1(gene name)|psi-mi:Kcnt1(display_short)|uniprotkb:Kiaa1422(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000058740(gene)|ensembl:ENSMUST00000114172(transcript)|go:"GO:0005228"(intracellular sodium activated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR013099(Ion transport 2)|mint:Q6ZPR4|refseq:NP_001289280.1|refseq:NP_780671.2	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:dqty8xDH9pIQhzgbYTeSOo4tLjA10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O35099	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-777493|uniprotkb:Q14AY5|ensembl:ENSMUSP00000093485	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:m3k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:Map3k5(gene name)|psi-mi:Map3k5(display_short)|uniprotkb:Ask1(gene name synonym)|uniprotkb:Mekk5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_032606.4|dip:DIP-38055N|ensembl:ENSMUSG00000071369(gene)|ensembl:ENSMUST00000095806(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010941"(regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902170"(cellular response to reactive nitrogen species)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:O35099|reactome:R-MMU-2559580	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:i1P8YtUNmpFauFUVVxzsMYoQYOw10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q08460	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26471757|imex:IM-28526-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	-	-	-	figure legend:ST2|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|comment:"Q1400 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rigid:91spKy0Ri8KaF9dBaFalkZlW0lc	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CJG0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99KH8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8400393|intact:MINT-4135908|ensembl:ENSMUSP00000078746	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:stk24_mouse(display_long)|uniprotkb:Stk24(gene name)|psi-mi:Stk24(display_short)|uniprotkb:Mammalian STE20-like protein kinase 3(gene name synonym)|uniprotkb:Mst3(gene name synonym)|uniprotkb:STE20-like kinase MST3(gene name synonym)|uniprotkb:Stk3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_663440.1|ensembl:ENSMUSG00000063410(gene)|ensembl:ENSMUST00000079817(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q99KH8|reactome:R-MMU-111465|reactome:R-MMU-75153	-	-	comment:mint|function:Protein kinase that act on both serine and threonine residues	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:2z5S5rvP41gzATaW0zz0rVP3aDM10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q569Z5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8372791|uniprotkb:Q6ZQ42|uniprotkb:Q8R0R6|intact:MINT-4118429|ensembl:ENSMUSP00000133245|ensembl:ENSMUSP00000153328	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ddx46_mouse(display_long)|uniprotkb:Ddx46(gene name)|psi-mi:Ddx46(display_short)|uniprotkb:Kiaa0801(gene name synonym)|uniprotkb:DEAD box protein 46(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001268984.1|ensembl:ENSMUSG00000021500(gene)|ensembl:ENSMUST00000172272(transcript)|ensembl:ENSMUST00000223736(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q569Z5|reactome:R-MMU-72163	-	-	comment:mint|function:Plays an essential role in splicing, either prior to, or during A complex formation	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:bR28iB8YRYIjcWqTcPYs+dSC6Go10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99J85	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8311244|intact:MINT-4104086	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nptxr_mouse(display_long)|uniprotkb:Nptxr(gene name)|psi-mi:Nptxr(display_short)|uniprotkb:Npr(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0008029"(pentraxin receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099150"(regulation of postsynaptic specialization assembly)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR030476|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|mint:Q99J85	-	-	comment:mint	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:AWabDfkkTcL+AMgJlRt5ntbJ5WU10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TPV2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8372821|uniprotkb:Q8BYK7|uniprotkb:Q80TU4|intact:MINT-4093781|uniprotkb:Q148V3	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dzip3_mouse(display_long)|uniprotkb:Dzip3(gene name)|psi-mi:Dzip3(display_short)|uniprotkb:Kiaa0675(gene name synonym)|uniprotkb:DAZ-interacting protein 3 homolog(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase DZIP3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR033103|refseq:NP_081617.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q7TPV2|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR041249|interpro:IPR043866|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|reactome:R-MMU-983168	-	-	comment:mint|function:E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Af5+nqZi0f8/jHDg+JzgOVOB0ic10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CHG7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-7027510|ensembl:ENSMUSP00000114119|intact:MINT-4133098|uniprotkb:E9QMD0	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rpgf2_mouse(display_long)|uniprotkb:Rapgef2(gene name)|psi-mi:Rapgef2(display_short)|uniprotkb:Kiaa0313(gene name synonym)|uniprotkb:Pdzgef1(gene name synonym)|uniprotkb:Neural RAP guanine nucleotide exchange protein(gene name synonym)|uniprotkb:PDZ domain-containing guanine nucleotide exchange factor 1(gene name synonym)|uniprotkb:Cyclic nucleotide ras GEF(gene name synonym)|uniprotkb:RA-GEF-1(gene name synonym)|uniprotkb:Ras/Rap1-associating GEF-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_006502317.1|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|go:"GO:0050699"(WW domain binding)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000159(Ras-association)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR018490|interpro:IPR023578|interpro:IPR029071|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030739|interpro:IPR036034|mint:Q8CHG7|reactome:R-MMU-5673001|ensembl:ENSMUSG00000062232(gene)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0021591"(ventricular system development)|go:"GO:0021884"(forebrain neuron development)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038180"(nerve growth factor signaling pathway)|ensembl:ENSMUST00000118100(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001764"(neuron migration)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0045202"(synapse)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048022"(negative regulation of melanin biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	comment:"fragmentation type: fragment"|comment:mint|comment:homomint|function:"Guanine nucleotide exchange factor (GEF) for Rap1, Rap1B and Rap2 GTPases"	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:gH1WVMkcR44bJMCVvh7NctDb5KI10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O70305	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8006253|uniprotkb:P97421|intact:MINT-1865582	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:atx2_mouse(display_long)|uniprotkb:Atxn2(gene name)|psi-mi:Atxn2(display_short)|uniprotkb:Atx2(gene name synonym)|uniprotkb:Sca2(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 2 protein homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR033093|refseq:NP_033151.2|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR025852|mint:O70305|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010603"(regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050905"(neuromuscular process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)	-	-	comment:mint	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:SbI0yjYObe6jYhmgokZb1LLJlP810090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6PGC1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8428992|uniprotkb:Q8C9H9|uniprotkb:Q8C9B7|intact:MINT-4112300|uniprotkb:Q8BQJ4|uniprotkb:Q8BT01|ensembl:ENSMUSP00000035244	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dhx29_mouse(display_long)|uniprotkb:Dhx29(gene name)|psi-mi:Dhx29(display_short)|uniprotkb:DEAH box protein 29(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_766182.2|ensembl:ENSMUSG00000042426(gene)|ensembl:ENSMUST00000038574(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0008494"(translation activator activity)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042255"(ribosome assembly)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR034730|mint:Q6PGC1	-	-	comment:mint	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:rORkrwC6jPYK8bp9O+7RaI5e9KI10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P97452	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8387462|uniprotkb:Q91X31|uniprotkb:Q3TK87|uniprotkb:Q6ZQI9|intact:MINT-4089312|ensembl:ENSMUSP00000023217	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:bop1_mouse(display_long)|uniprotkb:Bop1(gene name)|psi-mi:Bop1(display_short)|uniprotkb:Kiaa0124(gene name synonym)|uniprotkb:Block of proliferation 1 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_038509.1|ensembl:ENSMUSG00000022557(gene)|ensembl:ENSMUST00000023217(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000448"("cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070545"(PeBoW complex)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR012953(BOP1, N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR028598|interpro:IPR036322|mint:P97452|reactome:R-MMU-6791226	-	-	comment:mint|function:Required for maturation of the 25S and 5.8S ribosomal RNAs. Required for proper processing at four distinct sites located within the internal transcribed spacers ITS1 and ITS2 and the 3' external spacer. May serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rRNA	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:yVcQ/SLwxWkiqExrCi38DBDiE0g10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q91YW3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8381770|intact:EBI-8447300|intact:MINT-1838284|uniprotkb:Q60873|ensembl:ENSMUSP00000022734	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dnjc3_mouse(display_long)|uniprotkb:Dnajc3(gene name)|psi-mi:Dnajc3(display_short)|uniprotkb:P58ipk(gene name synonym)|uniprotkb:Interferon-induced, double-stranded RNA-activated protein kinase inhibitor(gene name synonym)|uniprotkb:Protein kinase inhibitor of 58 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_032955.2|ensembl:ENSMUSG00000022136(gene)|ensembl:ENSMUST00000022734(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036494"(positive regulation of translation initiation in response to endoplasmic reticulum stress)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070417"(cellular response to cold)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|mint:Q91YW3|rcsb pdb:3IEG|reactome:R-MMU-381426|reactome:R-MMU-6798695|reactome:R-MMU-8957275	-	-	comment:mint|function:"May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2/PKR to catalyze phosphorylation of the EIF2A. Co-chaperone of HSPA8/HSC70. Involved in the unfolded protein response (UPR) during ER stress. Regulates the activity and the autophosphorylation of EIF2AK2. Stimulates the ATPase activity of HSPA8 (By similarity). May inhibit EIF2AK3 activity during the ER stress response. Overexpression of DNAJC3 reduces EIF2AK3/PERK-mediated EIF2A phosphorylation"	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:5qmdmpCgH/9zUNnNXN0WHR9W2H410090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P50580	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-7550171|intact:MINT-1857756|ensembl:ENSMUSP00000026425|ensembl:ENSMUSP00000114434	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:pa2g4_mouse(display_long)|uniprotkb:Ebp1(gene name synonym)|uniprotkb:Pa2g4(gene name)|psi-mi:Pa2g4(display_short)|uniprotkb:Plfap(gene name synonym)|uniprotkb:Proliferation-associated protein 1(gene name synonym)|uniprotkb:Protein p38-2G4(gene name synonym)|uniprotkb:Mpp1(gene name synonym)|uniprotkb:IRES-specific cellular trans-acting factor 45 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035249.1|ensembl:ENSMUSG00000025364(gene)|ensembl:ENSMUST00000026425(transcript)|ensembl:ENSMUST00000131728(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0006417"(regulation of translation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000994(Peptidase M24, catalytic core)|interpro:IPR004545(Proliferation-associated protein 1)|interpro:IPR018349|interpro:IPR036005|interpro:IPR036388|interpro:IPR036390|mint:P50580|rcsb pdb:2V6C|rcsb pdb:6SWA|reactome:R-MMU-6798695	-	-	comment:mint|function:"May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly (By similarity). Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). Together with PTBP1 is required for the translation initiation on the foot-and-mouth disease virus (FMDV) IRES"	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:00qNeBIV6MQIU5EgEQI6zWdyPJ010090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9Z108	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8020609|intact:UNK-5561237|ensembl:ENSMUSP00000104859	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:stau1_mouse(display_long)|uniprotkb:Stau1(gene name)|psi-mi:Stau1(display_short)|uniprotkb:Stau(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035620.1|ensembl:ENSMUSG00000039536(gene)|ensembl:ENSMUST00000109236(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008298"(intracellular mRNA localization)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030425"(dendrite)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099010"(modification of postsynaptic structure)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR044475|mint:Q9Z108	-	-	comment:mint|function:"Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site"	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:9zPJq1T9MxPD12EiZZWLuRcCpTk10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9WTX2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8313024|ensembl:ENSMUSP00000002808|intact:MINT-4131019|uniprotkb:Q9CZB7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:prkra_mouse(display_long)|uniprotkb:Prkra(gene name)|psi-mi:Prkra(display_short)|uniprotkb:Rax(gene name synonym)|uniprotkb:Protein activator of the interferon-induced protein kinase(gene name synonym)|uniprotkb:PKR-associated protein X(gene name synonym)|uniprotkb:PKR-associating protein X(gene name synonym)|uniprotkb:Protein kinase, interferon-inducible double-stranded RNA-dependent activator(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000002731(gene)|ensembl:ENSMUST00000002808(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043583"(ear development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR033363|interpro:IPR044465|interpro:IPR044466|interpro:IPR044467|mint:Q9WTX2|reactome:R-MMU-203927|reactome:R-MMU-426486|refseq:NP_036001.1	-	-	comment:mint|function:"Activates EIF2AK2 in absence of double stranded RNA (dsRNA). Appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor"	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:FerGS9NkYTrz2ps8I+pY9Pn8TXQ10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3U319	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8440451|uniprotkb:Q8CHX4|uniprotkb:Q8BY03|uniprotkb:Q8BJA1|intact:MINT-4110865|uniprotkb:Q6ZQ75|ensembl:ENSMUSP00000146310	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:bre1b_mouse(display_long)|uniprotkb:Rnf40(gene name)|psi-mi:Rnf40(display_short)|uniprotkb:Bre1b(gene name synonym)|uniprotkb:Kiaa0661(gene name synonym)|uniprotkb:RING finger protein 40(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_758485.2|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q3U319|reactome:R-MMU-8866654|ensembl:ENSMUSG00000030816(gene)|ensembl:ENSMUST00000205694(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)	-	-	function:E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-120' of histone H2B. H2B 'Lys-120' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBE2E1/UBCH6. It thereby plays a central role in histone code and gene regulation. Required for transcriptional activation of Hox genes|comment:mint	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:sF6/LJ1K81T6H3WvcDC7RrtEg1c10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6A0A9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8327719|intact:MINT-1858841|uniprotkb:Q91Z16|uniprotkb:B3DFJ0|uniprotkb:A0PJK6|ensembl:ENSMUSP00000053877	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:f120a_mouse(display_long)|uniprotkb:Kiaa0183(gene name synonym)|uniprotkb:Ossa(gene name synonym)|uniprotkb:Oxidative stress-associated Src activator(gene name synonym)|uniprotkb:Protein FAM120A(gene name synonym)|uniprotkb:FAM120A(gene name)|psi-mi:FAM120A(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001028440.2|ensembl:ENSMUSG00000038014(gene)|ensembl:ENSMUST00000060805(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR026784|interpro:IPR029060|mint:Q6A0A9	-	-	comment:"fragmentation type: fragment"|comment:mint	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:tZj0TOhfuvvF4GaEPHI7jWpKyl810090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P59325	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8312397|ensembl:ENSMUSP00000061616|ensembl:ENSMUSP00000126825|ensembl:ENSMUSP00000152791|intact:MINT-1857485	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:if5_mouse(display_long)|uniprotkb:Eif5(gene name)|psi-mi:Eif5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000021282(gene)|ensembl:ENSMUST00000050993(transcript)|ensembl:ENSMUST00000166123(transcript)|ensembl:ENSMUST00000222375(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|mint:P59325|reactome:R-MMU-72702|reactome:R-MMU-72706|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|refseq:NP_829887.1|refseq:NP_775539.1	-	-	comment:mint|function:"Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F])"	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:OQ4olrPlHrkjB/J46gKEVh4EEyY10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q64152	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8316731|ensembl:ENSMUSP00000022163|intact:MINT-1851805|uniprotkb:Q64153|uniprotkb:Q6P3F3|uniprotkb:Q6GU63	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:btf3_mouse(display_long)|uniprotkb:Btf3(gene name)|psi-mi:Btf3(display_short)|uniprotkb:RNA polymerase B transcription factor 3(gene name synonym)|uniprotkb:Nascent polypeptide-associated complex subunit beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000021660(gene)|ensembl:ENSMUST00000022163(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005854"(nascent polypeptide-associated complex)|go:"GO:0015031"(protein transport)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR002715(Nascent polypeptide-associated complex NAC)|interpro:IPR038187|interpro:IPR039370|mint:Q64152|refseq:NP_663430.2|refseq:NP_001164011.1|dip:DIP-59968N	-	-	function:General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription|comment:mint	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ggS6MpV/CpLeK5L5/tUeOt3AazQ10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P26041	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8322611|uniprotkb:Q8BSN4|intact:MINT-1866505|uniprotkb:B1AX70|uniprotkb:Q3UL28|ensembl:ENSMUSP00000113071	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:moes_mouse(display_long)|uniprotkb:Msn(gene name)|psi-mi:Msn(display_short)|uniprotkb:Membrane-organizing extension spike protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_034963.2|ensembl:ENSMUSG00000031207(gene)|ensembl:ENSMUST00000117399(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001931"(uropod)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031143"(pseudopodium)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0042098"(T cell proliferation)|go:"GO:0043209"(myelin sheath)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051286"(cell tip)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070489"(T cell aggregation)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0072678"(T cell migration)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:2000401"(regulation of lymphocyte migration)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P26041|reactome:R-MMU-437239|rcsb pdb:4YL8	-	-	function:Probably involved in connections of major cytoskeletal structures to the plasma membrane|comment:mint	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Oy6Ki6PiaAzF58D07s8b5V42/dw10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9QWR8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8408113|uniprotkb:Q8VDK2|uniprotkb:Q8R437|intact:MINT-1849631|uniprotkb:O88620|ensembl:ENSMUSP00000023088	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nagab_mouse(display_long)|uniprotkb:Naga(gene name)|psi-mi:Naga(display_short)|uniprotkb:Alpha-galactosidase B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_032695.3|ensembl:ENSMUSG00000022453(gene)|ensembl:ENSMUST00000023088(transcript)|go:"GO:0004557"(alpha-galactosidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0008456"(alpha-N-acetylgalactosaminidase activity)|go:"GO:0009311"(oligosaccharide metabolic process)|go:"GO:0016052"(carbohydrate catabolic process)|go:"GO:0016139"(glycoside catabolic process)|go:"GO:0019377"(glycolipid catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046477"(glycosylceramide catabolic process)|interpro:IPR000111(Glycoside hydrolase, clan GH-D)|interpro:IPR002241(Glycoside hydrolase, family 27)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR035373|mint:Q9QWR8	-	-	comment:mint	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:FePYsDH6Mo8duXIXoo0mX+0smak10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O09167	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-7977824|intact:MINT-1858045	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl21_mouse(display_long)|uniprotkb:Rpl21(gene name)|psi-mi:Rpl21(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR008991(Translation protein SH3-like)|interpro:IPR018259|interpro:IPR036948|mint:O09167|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|interpro:IPR001147(Ribosomal protein L21e)	-	-	comment:mint	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:uEJx6Wv/rFvNeu2dalcIkOKkyxo10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9DB27	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8317814|intact:MINT-4128072|uniprotkb:Q3UUI6|intact:UNK-5416843|ensembl:ENSMUSP00000000365	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mcts1_mouse(display_long)|uniprotkb:Mcts1(gene name)|psi-mi:Mcts1(display_short)|uniprotkb:Multiple copies T-cell malignancies 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_081178.1|refseq:XP_006541598.1|ensembl:ENSMUSG00000000355(gene)|ensembl:ENSMUST00000000365(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0040008"(regulation of growth)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR002478(PUA)|interpro:IPR004521(Uncharacterized domain 2)|interpro:IPR015947(PUA-like)|interpro:IPR016437(Translation machinery-associated RNA binding protein, predicted)|interpro:IPR041366|mint:Q9DB27	-	-	comment:mint	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:kbGy09T3EiKnImwwO2ibi9XTUwg10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CGF7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-7964269|intact:MINT-7969933|uniprotkb:Q61051|uniprotkb:Q8C490|uniprotkb:Q8CHT8|uniprotkb:Q9R0R5|ensembl:ENSMUSP00000158288	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tcrg1_mouse(display_long)|uniprotkb:Tcerg1(gene name)|psi-mi:Tcerg1(display_short)|uniprotkb:Formin-binding protein 28(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 2S(gene name synonym)|uniprotkb:Taf2s(gene name synonym)|uniprotkb:Transcription factor CA150(gene name synonym)|uniprotkb:p144(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001034563.1|refseq:XP_006526178.1|refseq:NP_001276455.1|ensembl:ENSMUSG00000024498(gene)|ensembl:ENSMUST00000237602(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0042802"(identical protein binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR002713(FF)|interpro:IPR036020|interpro:IPR036517|mint:Q8CGF7|rcsb pdb:1E0L|rcsb pdb:2JUP|rcsb pdb:2RLY|rcsb pdb:2RM0|rcsb pdb:2YSI|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)	-	-	comment:mint	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:l0JizdwOK12oL38q8XfhOUyv6oM10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:B2RR83	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8572369|ensembl:ENSMUSP00000048340|intact:MINT-8174232	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ytdc2_mouse(display_long)|uniprotkb:Keen to exit meiosis leaving testes under-populated protein(gene name synonym)|uniprotkb:YTH domain-containing protein C2(gene name synonym)|uniprotkb:Ythdc2(gene name)|psi-mi:Ythdc2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR007275(YT521-B-like protein)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031083|interpro:IPR034083|interpro:IPR036770|interpro:IPR036867|mint:B2RR83|ensembl:ENSMUSG00000034653(gene)|ensembl:ENSMUST00000037763(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007286"(spermatid development)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048599"(oocyte development)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR001374(Single-stranded nucleic acid binding R3H)|refseq:NP_001156485.1	-	-	comment:mint	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:TxNENB71AFsznI6fFqBPUX8pgdA10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P80313	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-309306|ensembl:ENSMUSP00000032078	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tcph_mouse(display_long)|uniprotkb:Cct7(gene name)|psi-mi:Cct7(display_short)|uniprotkb:Ccth(gene name synonym)|uniprotkb:CCT-eta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_031664.3|ensembl:ENSMUSG00000030007(gene)|ensembl:ENSMUST00000032078(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012720(T-complex protein 1, eta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P80313|reactome:R-MMU-390471|reactome:R-MMU-6814122|reactome:R-MMU-9013418|reactome:R-MMU-9013422	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ds2hAlDoiHN/urDfVMjJhNumSqo10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CJ67	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-21991569|uniprotkb:Q8BSY8|uniprotkb:Q8CJ66|uniprotkb:Q8R175|uniprotkb:Q91Z19|uniprotkb:Q9D5N7|ensembl:ENSMUSP00000053190|ensembl:ENSMUSP00000124505	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:stau2_mouse(display_long)|uniprotkb:Stau2(gene name)|psi-mi:Stau2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001104742.1|refseq:NP_001333974.1|refseq:NP_079579.2|refseq:XP_006495591.1|refseq:XP_006495595.1|refseq:XP_011236689.1|refseq:XP_011236691.1|refseq:XP_017176591.1|ensembl:ENSMUSG00000025920(gene)|ensembl:ENSMUST00000054668(transcript)|ensembl:ENSMUST00000162751(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005874"(microtubule)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0019894"(kinesin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098964"(anterograde dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR044464|interpro:IPR044473|interpro:IPR044474|interpro:IPR044476|mint:Q8CJ67|rcsb pdb:1UHZ	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:94qldY96W9zvErbdJybhouGqEcY10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q69ZH9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472113|uniprotkb:Q8BNY7|uniprotkb:Q9JJD6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rhg23_mouse(display_long)|uniprotkb:Arhgap23(gene name)|psi-mi:Arhgap23(display_short)|uniprotkb:Kiaa1501(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 23(gene name synonym)|uniprotkb:MNCb-1301(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0005096"(GTPase activator activity)|go:"GO:0007165"(signal transduction)|reactome:R-MMU-8980692|reactome:R-MMU-9013149|mint:Q69ZH9|refseq:NP_067468.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR041489|interpro:IPR036034|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR041681|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR000198(RhoGAP)	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:KTCeDuLV+qHtInBwC3PzUFi0VO810090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80UM3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2554211|uniprotkb:Q9JID5|uniprotkb:Q811Z9	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:naa15_mouse(display_long)|uniprotkb:Narg1(gene name synonym)|uniprotkb:NMDA receptor-regulated protein 1(gene name synonym)|uniprotkb:Naa15(gene name)|psi-mi:Naa15(display_short)|uniprotkb:Nat1(gene name synonym)|uniprotkb:Tbdn-1(gene name synonym)|uniprotkb:Tubedown(gene name synonym)|uniprotkb:N-terminal acetyltransferase 1(gene name synonym)|uniprotkb:Protein tubedown-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR021183|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|go:"GO:0001525"(angiogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017196"(N-terminal peptidyl-methionine acetylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031415"(NatA complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0006474"(N-terminal protein amino acid acetylation)|mint:Q80UM3	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:hE4GwKw45rlC8XVDGmigsauWJMU10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P46662	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-644586|uniprotkb:Q8BR03|ensembl:ENSMUSP00000105536	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:merl_mouse(display_long)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)|uniprotkb:Nf2(gene name)|psi-mi:Nf2(display_short)|uniprotkb:Nf-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035028.2|refseq:XP_006514633.1|ensembl:ENSMUSG00000009073(gene)|ensembl:ENSMUST00000109910(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007398"(ectoderm development)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030175"(filopodium)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035330"(regulation of hippo signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042127"(regulation of cell population proliferation)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P46662|rcsb pdb:1ISN|rcsb pdb:3WA0|interpro:IPR000798(Ezrin/radixin/moesin ERM)|rcsb pdb:4P7I|rcsb pdb:4ZRK|reactome:R-MMU-2029482|reactome:R-MMU-5627123|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR000299(Band 4.1, N-terminal)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|refseq:NP_001239179.1|refseq:NP_001239180.1|refseq:XP_011241971.1|refseq:NP_001239181.1|refseq:NP_001239182.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:xDzmqR+fx4dbxWKxBm5h+sWkzEw10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O88532	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-645485|uniprotkb:Q3TY30|uniprotkb:Q8BS85|uniprotkb:Q8CGG5|uniprotkb:Q91VZ0|uniprotkb:Q9CT34|ensembl:ENSMUSP00000118911	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:zfr_mouse(display_long)|uniprotkb:Zfr(gene name)|psi-mi:Zfr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035897.2|ensembl:ENSMUSG00000022201(gene)|ensembl:ENSMUST00000122941(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR006561(DZF)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043519|mint:O88532	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ncNwFUEUk0r2XotuXm/9Tt4iB5w10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:B1AY10	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11707102|uniprotkb:Q3U2A7|uniprotkb:Q3UK95|uniprotkb:Q3UMW1|uniprotkb:Q7TPT4|uniprotkb:Q8CC59|uniprotkb:Q9DBC8|uniprotkb:Q9JKW7|ensembl:ENSMUSP00000095747	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nfx1_mouse(display_long)|uniprotkb:Nfx1(gene name)|psi-mi:Nfx1(display_short)|uniprotkb:Nuclear transcription factor, X box-binding protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001277377.1|refseq:NP_001277378.1|refseq:NP_076228.2|ensembl:ENSMUSG00000028423(gene)|ensembl:ENSMUST00000098143(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000967(Zinc finger, NF-X1-type)|interpro:IPR001374(Single-stranded nucleic acid binding R3H)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR019787|interpro:IPR034076|interpro:IPR034078|interpro:IPR036867|mint:B1AY10|go:"GO:0005730"(nucleolus)	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:fFzQDjd9a1arVzJAhXzDcvmhE7c10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:A2A690	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16733043|ensembl:ENSMUSP00000097904|uniprotkb:A2A683|uniprotkb:Q3TRZ3|uniprotkb:Q5EBP6|uniprotkb:Q69ZQ7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tanc2_mouse(display_long)|uniprotkb:Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2(gene name synonym)|uniprotkb:Tanc2(gene name)|psi-mi:Tanc2(display_short)|uniprotkb:Kiaa1148(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000053580(gene)|ensembl:ENSMUST00000100330(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0030424"(axon)|go:"GO:0043197"(dendritic spine)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099519"(dense core granule cytoskeletal transport)|interpro:IPR002110(Ankyrin)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|mint:A2A690|refseq:NP_851416.2	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:pr3yhn1QUhZm0o9/xXGd9g+QFoo10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9R1B9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16185280|ensembl:ENSMUSP00000133840|uniprotkb:E9QKB4|uniprotkb:Q9Z166	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:slit2_mouse(display_long)|uniprotkb:Slit2(gene name)|psi-mi:Slit2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000031558(gene)|ensembl:ENSMUST00000173107(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002689"(negative regulation of leukocyte chemotaxis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0021836"(chemorepulsion involved in postnatal olfactory bulb interneuron migration)|go:"GO:0021972"(corticospinal neuron axon guidance through spinal cord)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0050929"(induction of negative chemotaxis)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070100"(negative regulation of chemokine-mediated signaling pathway)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0071676"(negative regulation of mononuclear cell migration)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)|go:"GO:0090260"(negative regulation of retinal ganglion cell axon guidance)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|interpro:IPR032675|mint:Q9R1B9|reactome:R-MMU-376176|reactome:R-MMU-428890|reactome:R-MMU-8985586|reactome:R-MMU-9010553|go:"GO:0022029"(telencephalon cell migration)|refseq:NP_848919.3|dip:DIP-61876N	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:0t9tDMAtdhScxRbDi5grpBl8GT810090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q811S7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-5710174|uniprotkb:A4QPG4|uniprotkb:Q3UPR3|uniprotkb:Q3US11|uniprotkb:Q60786|uniprotkb:Q8C514|ensembl:ENSMUSP00000081946|ensembl:ENSMUSP00000150023	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ubip1_mouse(display_long)|uniprotkb:Ubp1(gene name)|psi-mi:Ubp1(display_short)|uniprotkb:Cp2b(gene name synonym)|uniprotkb:Nf2d9(gene name synonym)|uniprotkb:Nuclear factor 2d9(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001076788.1|refseq:NP_038727.1|refseq:XP_006512114.2|refseq:XP_006512117.2|ensembl:ENSMUSG00000009741(gene)|ensembl:ENSMUST00000084885(transcript)|ensembl:ENSMUST00000216558(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR007604(CP2 transcription factor)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037600|interpro:IPR041418|mint:Q811S7	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Nt11E5Wv/MovMgjsl1GUvjXxz8Y10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CR62	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-299894|ensembl:ENSMUSP00000014750	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:m2om_mouse(display_long)|uniprotkb:Slc25a11(gene name)|psi-mi:Slc25a11(display_short)|uniprotkb:Solute carrier family 25 member 11(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000014606(gene)|ensembl:ENSMUST00000014750(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0008272"(sulfate transport)|go:"GO:0015116"(sulfate transmembrane transporter activity)|go:"GO:0015117"(thiosulfate transmembrane transporter activity)|go:"GO:0015131"(oxaloacetate transmembrane transporter activity)|go:"GO:0015139"(alpha-ketoglutarate transmembrane transporter activity)|go:"GO:0015140"(malate transmembrane transporter activity)|go:"GO:0015141"(succinate transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0015709"(thiosulfate transport)|go:"GO:0015729"(oxaloacetate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0071422"(succinate transmembrane transport)|go:"GO:0071423"(malate transmembrane transport)|interpro:IPR018108|interpro:IPR023395|mint:Q9CR62|reactome:R-MMU-70263|refseq:NP_077173.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:fYdym44Y2a8dI7c6hjpN4ADNRgA10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80TR4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470923|ensembl:ENSMUSP00000025993|uniprotkb:Q9WVB5	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:slit1_mouse(display_long)|uniprotkb:Slit1(gene name)|psi-mi:Slit1(display_short)|uniprotkb:Kiaa0813(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000025993(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007097"(nuclear migration)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051964"(negative regulation of synapse assembly)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR006207(Cystine knot, C-terminal)|ensembl:ENSMUSG00000025020(gene)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|interpro:IPR032675|mint:Q80TR4|refseq:NP_056563.2|refseq:XP_011245502.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:8SeUazCGHiowSI+ACP8ezeOC8pg10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q61074	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-642919|ensembl:ENSMUSP00000031032	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ppm1g_mouse(display_long)|uniprotkb:Protein phosphatase 2C isoform gamma(gene name synonym)|uniprotkb:Protein phosphatase magnesium-dependent 1 gamma(gene name synonym)|uniprotkb:Protein phosphatase 1C(gene name synonym)|uniprotkb:Fibroblast growth factor-inducible protein 13(gene name synonym)|uniprotkb:Ppm1g(gene name)|psi-mi:Ppm1g(display_short)|uniprotkb:Fin13(gene name synonym)|uniprotkb:Ppm1c(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_032040.1|ensembl:ENSMUSG00000029147(gene)|ensembl:ENSMUST00000031032(transcript)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR000222(Protein phosphatase 2C,  manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:Q61074	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:OazpV/JqeZD+TpovURxYWY9t6VI10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9EPW0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-773431|uniprotkb:Q8CBJ8	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:inp4a_mouse(display_long)|uniprotkb:Inositol polyphosphate 4-phosphatase type I(gene name synonym)|uniprotkb:Inpp4a(gene name)|psi-mi:Inpp4a(display_short)|uniprotkb:Inositol polyphosphate 4-phosphatase-1(gene name synonym)|uniprotkb:Type I inositol 3,4-bisphosphate 4-phosphatase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001277726.1|refseq:NP_001277727.1|refseq:NP_001277728.1|refseq:NP_084542.2|refseq:NP_766559.2|interpro:IPR039034|mint:Q9EPW0|interpro:IPR035892|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006798"(polyphosphate catabolic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016316"(phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity)|go:"GO:0017161"(inositol-1,3,4-trisphosphate 4-phosphatase activity)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034597"(phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity)|go:"GO:0052828"(inositol-3,4-bisphosphate 4-phosphatase activity)|go:"GO:0055038"(recycling endosome membrane)|reactome:R-MMU-1660499|reactome:R-MMU-1660516|reactome:R-MMU-1855183|interpro:IPR000008(C2 calcium-dependent membrane targeting)	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:l/ZBtTwMJFCdvrqsTa7Nz/3tbpo10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q91WJ7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472091|uniprotkb:Q8K322|uniprotkb:Q8VC37	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:sps2l_mouse(display_long)|uniprotkb:Spats2l(gene name)|psi-mi:Spats2l(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|mint:Q91WJ7|refseq:NP_001158038.1|refseq:NP_659131.2|refseq:XP_006496278.1|refseq:XP_006496281.1|interpro:IPR009816(Protein of unknown function DUF1387)|interpro:IPR009060(UBA-like)	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:VhMNvlzLQNyI91NxpTGpOohOwwI10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q09XV5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-1169080|uniprotkb:Q3TV89|uniprotkb:Q5I1Z2|uniprotkb:Q6ZPM8|ensembl:ENSMUSP00000087184|ensembl:ENSMUSP00000142890	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:chd8_mouse(display_long)|uniprotkb:Chd8(gene name)|psi-mi:Chd8(display_short)|uniprotkb:Kiaa1564(gene name synonym)|uniprotkb:ATP-dependent helicase CHD8(gene name synonym)|uniprotkb:Axis duplication inhibitor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_963999.2|refseq:XP_006519539.1|ensembl:ENSMUSG00000053754(gene)|ensembl:ENSMUST00000089752(transcript)|ensembl:ENSMUST00000200169(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035176"(social behavior)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048565"(digestive tract development)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070615"|go:"GO:0071339"(MLL1 complex)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000330(SNF2-related)|interpro:IPR000953(Chromo domain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023780|interpro:IPR027417|interpro:IPR034724|interpro:IPR037259|interpro:IPR038718|mint:Q09XV5|reactome:R-MMU-3769402	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ZttrOvHiz/PMCKm+pScx4Tn1Af410090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8VE19	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16728240|ensembl:ENSMUSP00000039301|uniprotkb:E9QM00	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mio_mouse(display_long)|uniprotkb:Mios(gene name)|psi-mi:Mios(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR036322|interpro:IPR037593|mint:Q8VE19|reactome:R-MMU-9639288|ensembl:ENSMUSG00000042447(gene)|ensembl:ENSMUST00000040017(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|refseq:NP_663349.2|refseq:XP_006505149.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Ib8ROrOPZeyTPcH80k1OiKYT2vw10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8BLK9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472065|uniprotkb:Q3UDY3|uniprotkb:Q6PDY4|uniprotkb:Q8BMQ5|uniprotkb:Q8BX49	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ks6c1_mouse(display_long)|uniprotkb:Rps6kc1(gene name)|psi-mi:Rps6kc1(display_short)|uniprotkb:52 kDa ribosomal protein S6 kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005768"(endosome)|mint:Q8BLK9|refseq:NP_848890.3|interpro:IPR011009(Protein kinase-like)|interpro:IPR007330(MIT)|interpro:IPR036181|interpro:IPR001683(Phox-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR036871|interpro:IPR042132|interpro:IPR035053	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:+kb0oZEOTi5l0gFKvMbjssT6opI10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TPM1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16728307|ensembl:ENSMUSP00000035734|uniprotkb:A2AN31|uniprotkb:Q8C755	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:prc2b_mouse(display_long)|uniprotkb:HLA-B-associated transcript 2-like 1(gene name synonym)|uniprotkb:Proline-rich coiled-coil protein 2B(gene name synonym)|uniprotkb:Prrc2b(gene name)|psi-mi:Prrc2b(display_short)|uniprotkb:Bat2l(gene name synonym)|uniprotkb:Bat2l1(gene name synonym)|uniprotkb:Kiaa0515(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000039262(gene)|ensembl:ENSMUST00000036691(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0030154"(cell differentiation)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:Q7TPM1|refseq:NP_001153106.1|refseq:NP_766249.2	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:WlCA3MFhuVeSWOib983JRtCgwRI10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6P5D8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6907867|ensembl:ENSMUSP00000121835|uniprotkb:Q6PDM8|uniprotkb:Q6PE93|uniprotkb:Q6ZQ78|uniprotkb:Q811H3|uniprotkb:Q8BP09|uniprotkb:Q9D4M7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:smhd1_mouse(display_long)|uniprotkb:Smchd1(gene name)|psi-mi:Smchd1(display_short)|uniprotkb:Kiaa0650(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000024054(gene)|ensembl:ENSMUST00000127430(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001740"(Barr body)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006302"(double-strand break repair)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043584"(nose development)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0060820"(inactivation of X chromosome by heterochromatin assembly)|go:"GO:0060821"(obsolete inactivation of X chromosome by DNA methylation)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR036277|interpro:IPR036890|interpro:IPR038892|mint:Q6P5D8|rcsb pdb:6N64|refseq:NP_083163.3	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:hpvZulbZ6q3A01pCveP/AZKq2LU10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q5F2E7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11567759|uniprotkb:Q80TF1|uniprotkb:Q3V195|uniprotkb:Q3TCE2|ensembl:ENSMUSP00000098365	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nufp2_mouse(display_long)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:Kiaa1321(gene name synonym)|uniprotkb:Nufip2(gene name)|psi-mi:Nufip2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001019376.1|refseq:XP_006534125.1|ensembl:ENSMUSG00000037857(gene)|ensembl:ENSMUST00000100802(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q5F2E7	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:rckz1rTUY3/RppScoXLaw1Z9ipU10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P62900	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2527089|uniprotkb:P12947|ensembl:ENSMUSP00000083722|ensembl:ENSMUSP00000136354|ensembl:ENSMUSP00000137631	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl31_mouse(display_long)|uniprotkb:Rpl31(gene name)|psi-mi:Rpl31(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000073702(gene)|ensembl:ENSMUST00000086535(transcript)|ensembl:ENSMUST00000178079(transcript)|ensembl:ENSMUST00000179954(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|interpro:IPR000054(Ribosomal protein L31e)|interpro:IPR020052|interpro:IPR023621|mint:P62900|rcsb pdb:6SWA|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|reactome:R-MMU-156827|refseq:NP_444487.1|refseq:NP_001239147.1|refseq:NP_001239148.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:77LFR7/2somk6blVogZf1XFdJLk10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6P5D3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471284|ensembl:ENSMUSP00000083742|uniprotkb:Q3TS93|uniprotkb:Q6NZK4|uniprotkb:Q6P1B4|uniprotkb:Q8BI63|uniprotkb:Q8BIA2|uniprotkb:Q8R360	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dhx57_mouse(display_long)|uniprotkb:Dhx57(gene name)|psi-mi:Dhx57(display_short)|uniprotkb:DEAH box protein 57(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000035051(gene)|ensembl:ENSMUST00000086555(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006575(RWD)|interpro:IPR007502(Helicase-associated region)|interpro:IPR009060(UBA-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR027417|interpro:IPR036855|interpro:IPR042615|mint:Q6P5D3|refseq:NP_001157231.1|refseq:NP_945180.2|refseq:XP_006523510.1|refseq:XP_006523511.1|refseq:XP_017172691.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:nAZbsulRL3ILa8GPejiItndIZts10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O70161	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-773657|uniprotkb:Q505A1|uniprotkb:Q80TW9|uniprotkb:Q8VCU5|ensembl:ENSMUSP00000100964	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:pi51c_mouse(display_long)|uniprotkb:Pip5k1c(gene name)|psi-mi:Pip5k1c(display_short)|uniprotkb:Kiaa0589(gene name synonym)|uniprotkb:Phosphatidylinositol 4-phosphate 5-kinase type I gamma(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001140159.1|refseq:NP_032870.2|refseq:NP_001280575.1|refseq:NP_001280576.1|ensembl:ENSMUSG00000034902(gene)|ensembl:ENSMUST00000105327(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001931"(uropod)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007409"(axonogenesis)|go:"GO:0010008"(endosome membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0070527"(platelet aggregation)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|mint:O70161|rcsb pdb:1Y19|rcsb pdb:2H7D|rcsb pdb:2H7E|reactome:R-MMU-1660499|reactome:R-MMU-399955|reactome:R-MMU-6811558|reactome:R-MMU-8856828	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:nyRuUZQSpe2dc2XN1CZV8Oy5Yvk10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6PHQ8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472042|ensembl:ENSMUSP00000022038|uniprotkb:Q05CD3|uniprotkb:Q8BYJ9|uniprotkb:Q8K3H2	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:naa35_mouse(display_long)|uniprotkb:Naa35(gene name)|psi-mi:Naa35(display_short)|uniprotkb:Egap(gene name synonym)|uniprotkb:Mak10(gene name synonym)|uniprotkb:Embryonic growth-associated protein(gene name synonym)|uniprotkb:Protein MAK10 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000021555(gene)|ensembl:ENSMUST00000022038(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006474"(N-terminal protein amino acid acetylation)|go:"GO:0017196"(N-terminal peptidyl-methionine acetylation)|go:"GO:0031417"(NatC complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048659"(smooth muscle cell proliferation)|interpro:IPR007244("Mak10 subunit, NatC N(alpha)-terminal acetyltransferase")|mint:Q6PHQ8|refseq:NP_084429.2|refseq:XP_006517522.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:WrX/P5zW3J5XThFBh5aYbHo3xo410090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8R502	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-20718060|ensembl:ENSMUSP00000066015|uniprotkb:Q3TEP9|uniprotkb:Q8C296|uniprotkb:Q8R0N7|uniprotkb:Q8R3G5	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:lrc8c_mouse(display_long)|uniprotkb:Factor for adipocyte differentiation 158(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 8C(gene name synonym)|uniprotkb:Lrrc8c(gene name)|psi-mi:Lrrc8c(display_short)|uniprotkb:Ad158(gene name synonym)|uniprotkb:Fad158(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000054720(gene)|ensembl:ENSMUST00000067924(transcript)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034702"(ion channel complex)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098656"(anion transmembrane transport)|go:"GO:0140361"(cyclic-GMP-AMP transmembrane import across plasma membrane)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR021040|interpro:IPR032675|mint:Q8R502|reactome:R-MMU-5223345|go:"GO:0015734"(taurine transport)|refseq:NP_598658.1|refseq:XP_006534748.1|refseq:XP_017176062.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:3H5OySBpEv3c7ryGwyI1Ve3zOU010090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:E9Q6P5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472026|ensembl:ENSMUSP00000052107	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ttc7b_mouse(display_long)|uniprotkb:Ttc7b(gene name)|psi-mi:Ttc7b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000033530(gene)|ensembl:ENSMUST00000062957(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|mint:E9Q6P5|refseq:NP_001028385.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ZPk8i1GIUVQ38oFmzSf936xq0lE10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CQJ6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472008|ensembl:ENSMUSP00000023869|uniprotkb:Q3UXY1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:denr_mouse(display_long)|uniprotkb:Denr(gene name)|psi-mi:Denr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000023106(gene)|ensembl:ENSMUST00000023869(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR001950(Translation initiation factor SUI1)|interpro:IPR005873(Density-regulated protein DRP1)|interpro:IPR036877|mint:Q9CQJ6|refseq:NP_080879.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Ng4Exx8ebd9KHHd3492HziiDlIo10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q641P0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471986|ensembl:ENSMUSP00000085578|uniprotkb:Q7TSH1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:arp3b_mouse(display_long)|uniprotkb:Actr3b(gene name)|psi-mi:Actr3b(display_short)|uniprotkb:ARP3-beta(gene name synonym)|uniprotkb:Actin-like protein 3B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000056367(gene)|ensembl:ENSMUST00000088244(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0042995"(cell projection)|interpro:IPR004000(Actin/actin-like)|interpro:IPR020902|interpro:IPR043129|mint:Q641P0|refseq:NP_001004365.1|refseq:NP_001297433.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Dgvqzk0jTsysP2LG9zi2YYMNax410090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6PGL7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-5298041|uniprotkb:Q3TQ99|uniprotkb:Q80TW8|uniprotkb:Q80UQ4|uniprotkb:Q8CAP0|ensembl:ENSMUSP00000038983	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:wasc2_mouse(display_long)|uniprotkb:Washc2(gene name)|psi-mi:Washc2(display_short)|uniprotkb:D6Wsu116e(gene name synonym)|uniprotkb:Fam21(gene name synonym)|uniprotkb:Kiaa0592(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080861.2|ensembl:ENSMUSG00000024104(gene)|ensembl:ENSMUST00000036759(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0015031"(protein transport)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071203"(WASH complex)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1905394"(retromer complex binding)|interpro:IPR029341|mint:Q6PGL7	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ZahcV9CREm4afcw7WRGKN5S9w8c10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:A2AN08	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-4285947|uniprotkb:A2AN07|uniprotkb:A2AN09|uniprotkb:A2AN10|uniprotkb:A2AN11|uniprotkb:Q52KI4|uniprotkb:Q6PB49|uniprotkb:Q6PFC7|uniprotkb:Q80Y11|uniprotkb:Q8BGB9|uniprotkb:Q8C3E8|uniprotkb:Q8C4W5|uniprotkb:Q8C8X7|uniprotkb:Q8CGE0|uniprotkb:Q8CHF3|ensembl:ENSMUSP00000095433	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ubr4_mouse(display_long)|uniprotkb:Kiaa0462(gene name synonym)|uniprotkb:Zubr1(gene name synonym)|uniprotkb:N-recognin-4(gene name synonym)|uniprotkb:Ubr4(gene name)|psi-mi:Ubr4(display_short)|uniprotkb:Zinc finger UBR1-type protein 1(gene name synonym)|uniprotkb:p600(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001153791.1|dip:DIP-61499N|ensembl:ENSMUSG00000066036(gene)|ensembl:ENSMUST00000097822(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025704|interpro:IPR036322|mint:A2AN08|reactome:R-MMU-6798695|reactome:R-MMU-983168|go:"GO:0016021"(integral component of membrane)	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:dTpQoZkH0+rwfrguOvzwrbPh0+Y10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P12970	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-773955|uniprotkb:Q91YM3|ensembl:ENSMUSP00000099962	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl7a_mouse(display_long)|uniprotkb:Surfeit locus protein 3(gene name synonym)|uniprotkb:Rpl7a(gene name)|psi-mi:Rpl7a(display_short)|uniprotkb:Surf3(gene name synonym)|uniprotkb:Surf-3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_038749.1|ensembl:ENSMUSG00000062647(gene)|ensembl:ENSMUST00000102898(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|interpro:IPR001921(Ribosomal protein L7A)|interpro:IPR004037(Ribosomal protein L7Ae)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|mint:P12970|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:XRP8YT3AaHxiv41NmJygfWNtBEs10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q01853	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-80597|ensembl:ENSMUSP00000030164|uniprotkb:Q3TFH9|uniprotkb:Q3TIM2|uniprotkb:Q3TXN9|uniprotkb:Q6PI18|uniprotkb:Q8BSR6|uniprotkb:Q8CEG4	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tera_mouse(display_long)|uniprotkb:Vcp(gene name)|psi-mi:Vcp(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:Q01853|rcsb pdb:1E32|rcsb pdb:1R7R|rcsb pdb:1S3S|rcsb pdb:2PJH|rcsb pdb:3CF0|rcsb pdb:3CF1|rcsb pdb:3CF2|rcsb pdb:3CF3|reactome:R-MMU-110320|reactome:R-MMU-3371511|reactome:R-MMU-382556|reactome:R-MMU-532668|reactome:R-MMU-5358346|reactome:R-MMU-5689877|reactome:R-MMU-5689896|reactome:R-MMU-6798695|reactome:R-MMU-8876725|reactome:R-MMU-9013407|ensembl:ENSMUSG00000028452(gene)|ensembl:ENSMUST00000030164(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0019904"(protein domain specific binding)|refseq:NP_033529.3|dip:DIP-29796N	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3TIV5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-25773832|ensembl:ENSMUSP00000080301|uniprotkb:Q3TWQ0|uniprotkb:Q3U855|uniprotkb:Q8K2B6|uniprotkb:Q8K346|uniprotkb:Q9CVM4|uniprotkb:Q9DAP2	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:zc3hf_mouse(display_long)|uniprotkb:Zc3h15(gene name)|psi-mi:Zc3h15(display_short)|uniprotkb:Dfrp1(gene name synonym)|uniprotkb:DRG family-regulatory protein 1(gene name synonym)|uniprotkb:Epo-immediate response gene protein FM22(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	mint:Q3TIV5|ensembl:ENSMUSG00000027091(gene)|ensembl:ENSMUST00000081591(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR032378|interpro:IPR036855|interpro:IPR041367|refseq:NP_081210.2	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:el66Odd1v1axut1gJu9ztAWGS+g10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q05D44	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471954|ensembl:ENSMUSP00000027252|uniprotkb:Q3SYI4|uniprotkb:Q3TQJ8|uniprotkb:Q3UL37|uniprotkb:Q3UM39|uniprotkb:Q6PAI0|uniprotkb:Q8CFF4|uniprotkb:Q8CGD6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:if2p_mouse(display_long)|uniprotkb:Eif5b(gene name)|psi-mi:Eif5b(display_short)|uniprotkb:If2(gene name synonym)|uniprotkb:Translation initiation factor IF-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000026083(gene)|ensembl:ENSMUST00000027252(transcript)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0046872"(metal ion binding)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR015760(Translation initiation factor 2 related)|interpro:IPR023115|interpro:IPR027417|interpro:IPR036925|mint:Q05D44|reactome:R-MMU-72706|refseq:NP_938045.2	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:I/f4dge9EuoZmhRTG/BxM27HaHM10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P55194	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2642510|uniprotkb:E9QMQ2|uniprotkb:Q99KK8|ensembl:ENSMUSP00000001226|uniprotkb:A2A5V4	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:3bp1_mouse(display_long)|uniprotkb:Sh3bp1(gene name)|psi-mi:Sh3bp1(display_short)|uniprotkb:3bp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000022436(gene)|ensembl:ENSMUST00000001226(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030834"(regulation of actin filament depolymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000198(RhoGAP)|interpro:IPR004148(BAR)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR027267|mint:P55194|rcsb pdb:1ABO|reactome:R-MMU-9013149|refseq:NP_001303613.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:xZnGbYRBdoFCbDG2oFc9FfUrl1o10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9WUA2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11707271|uniprotkb:Q9CWZ8|ensembl:ENSMUSP00000069508|ensembl:ENSMUSP00000129828	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:syfb_mouse(display_long)|uniprotkb:Farsb(gene name)|psi-mi:Farsb(display_short)|uniprotkb:Farsl(gene name synonym)|uniprotkb:Farslb(gene name synonym)|uniprotkb:Frsb(gene name synonym)|uniprotkb:Phenylalanyl-tRNA synthetase beta subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001265004.1|refseq:NP_035941.2|ensembl:ENSMUSG00000026245(gene)|ensembl:ENSMUST00000068333(transcript)|ensembl:ENSMUST00000170217(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006432"(phenylalanyl-tRNA aminoacylation)|go:"GO:0009328"(phenylalanine-tRNA ligase complex)|go:"GO:0051290"(protein heterotetramerization)|interpro:IPR004531(Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archae/euk cytosolic)|interpro:IPR005146(B3/B4 tRNA-binding domain)|interpro:IPR005147(tRNA synthetase, B5)|interpro:IPR009061(Putative DNA binding)|interpro:IPR020825|interpro:IPR040659|mint:Q9WUA2|interpro:IPR041616	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:qdABVIohiIx9CxsmlBUUYXMkRh810090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q62205	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471914|ensembl:ENSMUSP00000097642|ensembl:ENSMUSP00000126528|uniprotkb:A2ASI7|uniprotkb:Q5DTI0	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:scn9a_mouse(display_long)|uniprotkb:Scn9a(gene name)|psi-mi:Scn9a(display_short)|uniprotkb:Kiaa4197(gene name synonym)|uniprotkb:Peripheral sodium channel 1(gene name synonym)|uniprotkb:Sodium channel protein type IX subunit alpha(gene name synonym)|uniprotkb:Voltage-gated sodium channel subunit alpha Nav1.7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0019228"(neuronal action potential)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0031402"(sodium ion binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0086010"(membrane depolarization during action potential)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001696(Na+ channel)|interpro:IPR005821(Ion transport)|interpro:IPR010526(Sodium ion transport-associated)|interpro:IPR024583|interpro:IPR027359|interpro:IPR028803|interpro:IPR043203|go:"GO:0009791"(post-embryonic development)|interpro:IPR044564|mint:Q62205|reactome:R-MMU-5576892|ensembl:ENSMUSG00000075316(gene)|ensembl:ENSMUST00000100064(transcript)|ensembl:ENSMUST00000164384(transcript)|go:"GO:0001518"(voltage-gated sodium channel complex)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009636"(response to toxic substance)|refseq:NP_001277603.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:mNdjmK12WDqjeQ90IBjVI+TmHHA10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6P9K8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-771526|uniprotkb:Q6ZPU2|uniprotkb:Q8BWU2|uniprotkb:Q8BX99|uniprotkb:Q9CXH0|ensembl:ENSMUSP00000024958	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cski1_mouse(display_long)|uniprotkb:CASK-interacting protein 1(gene name synonym)|uniprotkb:Caskin1(gene name)|psi-mi:Caskin1(display_short)|uniprotkb:Kiaa1306(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_082213.2|refseq:XP_006524378.1|ensembl:ENSMUSG00000033597(gene)|ensembl:ENSMUST00000024958(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR001452(Src homology-3)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR027013|interpro:IPR032117|interpro:IPR032232|interpro:IPR035495|interpro:IPR035497|interpro:IPR035498|interpro:IPR036028|interpro:IPR036770|mint:Q6P9K8	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:zLkBAG7MLTXtMQ0HlY2ox2AumUE10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q69ZU6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-9673461|uniprotkb:Q3TP01|uniprotkb:Q3UWV1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ths7a_mouse(display_long)|uniprotkb:Thsd7a(gene name)|psi-mi:Thsd7a(display_short)|uniprotkb:Gm837(gene name synonym)|uniprotkb:Kiaa0960(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	mint:Q69ZU6|interpro:IPR000884(Thrombospondin, type I)|refseq:NP_001158277.1|interpro:IPR036383|interpro:IPR044004|go:"GO:0001525"(angiogenesis)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0098846"(podocyte foot)|reactome:R-MMU-5173214	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:/qTgHz4eRmV8fo7eOtIiStWEzrw10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9Z1B3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-397636|uniprotkb:Q62075|uniprotkb:Q8K5A5|uniprotkb:Q8K5A6|uniprotkb:Q9Z0E5|uniprotkb:Q9Z2T5|uniprotkb:Q6PDH1|ensembl:ENSMUSP00000105743	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:plcb1_mouse(display_long)|uniprotkb:Plcb1(gene name)|psi-mi:Plcb1(display_short)|uniprotkb:Phosphoinositide phospholipase C-beta-1(gene name synonym)|uniprotkb:Phospholipase C-beta-1(gene name synonym)|uniprotkb:PLC-154(gene name synonym)|uniprotkb:Plcb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001139302.1|refseq:NP_062651.2|ensembl:ENSMUSG00000051177(gene)|ensembl:ENSMUST00000110116(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0001556"(oocyte maturation)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007613"(memory)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031161"(phosphatidylinositol catabolic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032957"(inositol trisphosphate metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034284"(response to monosaccharide)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0060466"(activation of meiosis involved in egg activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0080154"(regulation of fertilization)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099178"(regulation of retrograde trans-synaptic signaling by endocanabinoid)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902618"(cellular response to fluoride)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1905631"(cellular response to glyceraldehyde)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000438"(negative regulation of monocyte extravasation)|go:"GO:2000560"(positive regulation of CD24 production)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR009535(Protein of unknown function DUF1154)|go:"GO:0043209"(myelin sheath)|interpro:IPR014815(PLC-beta, C-terminal)|interpro:IPR015359(Phospholipase C, phosphoinositol-specific, EF-hand-like)|interpro:IPR016280(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta)|interpro:IPR017946|interpro:IPR028400|interpro:IPR035892|interpro:IPR037862|interpro:IPR042531|mint:Q9Z1B3|reactome:R-MMU-112043|reactome:R-MMU-1855204|reactome:R-MMU-399997|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-418217|reactome:R-MMU-434316|reactome:R-MMU-500657|interpro:IPR011992(EF-Hand type)	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:OdorlKjHTBQOboAmplMz5kjIwAs10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q922K7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16729640|uniprotkb:Q3U4W9	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nop2_mouse(display_long)|uniprotkb:Nucleolar protein 1(gene name synonym)|uniprotkb:Nucleolar protein 2 homolog(gene name synonym)|uniprotkb:Proliferating-cell nucleolar antigen p120(gene name synonym)|uniprotkb:Proliferation-associated nucleolar protein p120(gene name synonym)|uniprotkb:Nop2(gene name)|psi-mi:Nop2(display_short)|uniprotkb:Nol1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0001510"(RNA methylation)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009383"("rRNA (cytosine-C5-)-methyltransferase activity")|go:"GO:0070475"(rRNA base methylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|mint:Q922K7|interpro:IPR018314|interpro:IPR031341|interpro:IPR001678("Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p")|interpro:IPR011023(Nop2p)|interpro:IPR012586(P120R)|interpro:IPR023267|interpro:IPR023273|interpro:IPR029063	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:BAr9p7p6IhfUcMmdkp8XMMPQsxk10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6VH22	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-22226681|ensembl:ENSMUSP00000049335|uniprotkb:Q6NZK1|uniprotkb:Q80TI4|uniprotkb:Q80W19|uniprotkb:Q9DAB0	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:if172_mouse(display_long)|uniprotkb:Ift172(gene name)|psi-mi:Ift172(display_short)|uniprotkb:Kiaa1179(gene name synonym)|uniprotkb:Wim(gene name synonym)|uniprotkb:Protein wimple(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0060271"(cilium assembly)|go:"GO:0060348"(bone development)|go:"GO:0061525"(hindgut development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097228"(sperm principal piece)|go:"GO:0097598"(sperm cytoplasmic droplet)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR036322|mint:Q6VH22|reactome:R-MMU-5610787|reactome:R-MMU-5620924|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008544"(epidermis development)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021915"(neural tube development)|go:"GO:0030992"(intraciliary transport particle B)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031514"(motile cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060173"(limb development)|go:"GO:0007368"(determination of left/right symmetry)|ensembl:ENSMUSG00000038564(gene)|ensembl:ENSMUST00000041565(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001841"(neural tube formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|refseq:NP_080574.5	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:qKlWtm735I1OrvYPmj7ZUyI3ZDA10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9JIK5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2551674|uniprotkb:Q3TVJ3|ensembl:ENSMUSP00000042691|uniprotkb:Q9WV45	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ddx21_mouse(display_long)|uniprotkb:Nucleolar RNA helicase II(gene name synonym)|uniprotkb:Nucleolar RNA helicase Gu(gene name synonym)|uniprotkb:RH II/Gu(gene name synonym)|uniprotkb:Gu-alpha(gene name synonym)|uniprotkb:DEAD box protein 21(gene name synonym)|uniprotkb:Ddx21(gene name)|psi-mi:Ddx21(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000020075(gene)|ensembl:ENSMUST00000045866(transcript)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0019843"(rRNA binding)|go:"GO:0030515"(snoRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0062176"(R-loop disassembly)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012562(GUCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR035979|mint:Q9JIK5|rcsb pdb:3ZIN|reactome:R-MMU-5250924|reactome:R-MMU-6791226|go:"GO:0051607"(defense response to virus)|refseq:NP_062426.2|dip:DIP-48574N	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:VMHd6Qxsw72ljg+FE39/O559ynI10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P26040	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-645505|uniprotkb:Q80ZT8|uniprotkb:Q9DCI1|ensembl:ENSMUSP00000063734	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ezri_mouse(display_long)|uniprotkb:Vil2(gene name synonym)|uniprotkb:p81(gene name synonym)|uniprotkb:Cytovillin(gene name synonym)|uniprotkb:Villin-2(gene name synonym)|uniprotkb:Ezr(gene name)|psi-mi:Ezr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_033536.2|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044297"(cell body)|go:"GO:0044393"(microspike)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097454"(Schwann cell microvillus)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902896"(terminal web assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|interpro:IPR008954(Moesin)|mint:P26040|reactome:R-MMU-373752|reactome:R-MMU-437239|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|ensembl:ENSMUSG00000052397(gene)|ensembl:ENSMUST00000064234(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0001931"(uropod)|go:"GO:0001951"(intestinal D-glucose absorption)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:PspmkV3JA32h1VGLkUgha3a59AA10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O70311	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471892|ensembl:ENSMUSP00000080600	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nmt2_mouse(display_long)|uniprotkb:Nmt2(gene name)|psi-mi:Nmt2(display_short)|uniprotkb:"Myristoyl-CoA:protein N-myristoyltransferase 2"(gene name synonym)|uniprotkb:Peptide N-myristoyltransferase 2(gene name synonym)|uniprotkb:Type II N-myristoyltransferase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000026643(gene)|ensembl:ENSMUST00000081932(transcript)|go:"GO:0004379"(glycylpeptide N-tetradecanoyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006499"(N-terminal protein myristoylation)|go:"GO:0019898"(extrinsic component of membrane)|interpro:IPR000903("Myristoyl-CoA:protein N-myristoyltransferase")|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR022676|interpro:IPR022677|interpro:IPR022678|mint:O70311|reactome:R-MMU-2514859|go:"GO:0018008"(N-terminal peptidyl-glycine N-myristoylation)|refseq:NP_032734.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ZppOYRj6P8eXClw0oF//uxkFgVo10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P97393	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-645877|uniprotkb:E9Q0L8	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rhg05_mouse(display_long)|uniprotkb:Rho-type GTPase-activating protein 5(gene name synonym)|uniprotkb:p190-B(gene name synonym)|uniprotkb:Arhgap5(gene name)|psi-mi:Arhgap5(display_short)|uniprotkb:Rhogap5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR002713(FF)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR000198(RhoGAP)|interpro:IPR001806(Ras GTPase)|interpro:IPR032835|interpro:IPR027417|interpro:IPR039006|interpro:IPR039007|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0042169"(SH2 domain binding)|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013405|reactome:R-MMU-9013406|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-9696264|reactome:R-MMU-9696270|reactome:R-MMU-9696273|interpro:IPR036517|mint:P97393	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:UZnXFwmIleOpeOC7GjMIOXOz2yg10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P62849	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11567545|uniprotkb:P16632|uniprotkb:Q6PDB5|uniprotkb:Q642L0|ensembl:ENSMUSP00000152944	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rs24_mouse(display_long)|uniprotkb:Rps24(gene name)|psi-mi:Rps24(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035427.2|refseq:NP_997517.1|refseq:NP_997518.1|refseq:XP_006518797.1|interpro:IPR001976(Ribosomal protein S24e)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR018098|mint:P62849|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|ensembl:ENSMUSG00000025290(gene)|ensembl:ENSMUST00000225023(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042274"(ribosomal small subunit biogenesis)	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:M/qkRxabHx9PFaOM7EwKDOOwu7Q10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80WG5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-20718010|ensembl:ENSMUSP00000092690|ensembl:ENSMUSP00000109284|ensembl:ENSMUSP00000139038|uniprotkb:A2AQZ0	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:lrc8a_mouse(display_long)|uniprotkb:Protein ebouriffe(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 8A(gene name synonym)|uniprotkb:Lrrc8a(gene name)|psi-mi:Lrrc8a(display_short)|uniprotkb:Lrrc8(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000099041(gene)|ensembl:ENSMUST00000095078(transcript)|ensembl:ENSMUST00000113654(transcript)|ensembl:ENSMUST00000139454(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002329"(pre-B cell differentiation)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0015734"(taurine transport)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034702"(ion channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0098656"(anion transmembrane transport)|go:"GO:0140360"(cyclic-GMP-AMP transmembrane transporter activity)|go:"GO:0140361"(cyclic-GMP-AMP transmembrane import across plasma membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|ensembl:ENSMUSG00000007476(gene)|interpro:IPR021040|interpro:IPR032675|mint:Q80WG5|rcsb pdb:6FNW|rcsb pdb:6G8Z|rcsb pdb:6G9L|rcsb pdb:6G9O|rcsb pdb:6NZW|rcsb pdb:6NZZ|rcsb pdb:6O00|rcsb pdb:7M17|rcsb pdb:7M19|reactome:R-MMU-5223345|refseq:NP_808393.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:a39hFvsEXuauN4cwEgT+rKHU3oo10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9D1M0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-4285415|uniprotkb:Q99M12|uniprotkb:Q9D712|ensembl:ENSMUSP00000032440	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:sec13_mouse(display_long)|uniprotkb:Sec13(gene name)|psi-mi:Sec13(display_short)|uniprotkb:Sec13l1(gene name synonym)|uniprotkb:SEC13-like protein 1(gene name synonym)|uniprotkb:SEC13-related protein(gene name synonym)|uniprotkb:GATOR complex protein SEC13(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_077168.2|ensembl:ENSMUSG00000030298(gene)|ensembl:ENSMUST00000032440(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032527"(protein exit from endoplasmic reticulum)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051028"(mRNA transport)|go:"GO:0061700"(GATOR2 complex)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:0090114"(COPII-coated vesicle budding)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR037363|interpro:IPR037596|mint:Q9D1M0|reactome:R-MMU-141444|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-170822|reactome:R-MMU-191859|reactome:R-MMU-204005|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3108214|reactome:R-MMU-3232142|reactome:R-MMU-3301854|reactome:R-MMU-3371453|reactome:R-MMU-4085377|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-5578749|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9615933|reactome:R-MMU-9639288|reactome:R-MMU-9648025|reactome:R-MMU-983170|interpro:IPR036322	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:40KHYuvc/jVIxhLJTKivv2NRm7I10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80VC9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2125556|uniprotkb:Q5DTW9|uniprotkb:Q8BUZ0|uniprotkb:E9Q5B0|uniprotkb:U5LGR7|uniprotkb:U5LGS1|uniprotkb:U5LGS5|uniprotkb:U5LGT0|uniprotkb:U5LHT8|uniprotkb:U5LHU4|uniprotkb:U5LHW1|uniprotkb:U5LHW4|uniprotkb:U5LHW9|uniprotkb:U5LK15|uniprotkb:U5LK19|uniprotkb:U5LK24|uniprotkb:U5LK70|uniprotkb:U5LK74|uniprotkb:U5LK79|ensembl:ENSMUSP00000058958	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:camp3_mouse(display_long)|uniprotkb:Marshalin(gene name synonym)|uniprotkb:Camsap3(gene name)|psi-mi:Camsap3(display_short)|uniprotkb:Protein Nezha(gene name synonym)|uniprotkb:Kiaa1543(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001157221.1|refseq:NP_081447.2|dip:DIP-52404N|refseq:NP_001334040.1|refseq:NP_001334041.1|refseq:NP_001334042.1|refseq:XP_006508937.1|refseq:XP_006508939.1|refseq:XP_006508941.1|ensembl:ENSMUSG00000044433(gene)|ensembl:ENSMUST00000057028(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003341"(cilium movement)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005915"(zonula adherens)|go:"GO:0005930"(axoneme)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030507"(spectrin binding)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031514"(motile cilium)|go:"GO:0033043"(regulation of organelle organization)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0036064"(ciliary basal body)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045218"(zonula adherens maintenance)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:1903358"(regulation of Golgi organization)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011033(PRC-barrel-like)|interpro:IPR014797(Protein of unknown function DUF1781)|interpro:IPR022613|interpro:IPR031372|interpro:IPR032940|interpro:IPR036872|interpro:IPR038209|mint:Q80VC9|rcsb pdb:1UGJ|rcsb pdb:5LZN|rcsb pdb:5M50|rcsb pdb:5OW5	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Z30CkFi9SutmAZxuqpznPko7qZw10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3LAC4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471859|ensembl:ENSMUSP00000027056|uniprotkb:E9QMG3|uniprotkb:Q3UQI2|uniprotkb:Q3UU18|uniprotkb:Q9CXD5	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:prex2_mouse(display_long)|uniprotkb:Prex2(gene name)|psi-mi:Prex2(display_short)|uniprotkb:Depdc2(gene name synonym)|uniprotkb:DEP domain-containing protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000048960(gene)|ensembl:ENSMUST00000027056(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0048813"(dendrite morphogenesis)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR037367|mint:Q3LAC4|reactome:R-MMU-8948751|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|refseq:NP_083801.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:WFnLEKIfvbYlUiklWxhr1Mw11ZA10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6WVG3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16730134|uniprotkb:Q3T9E3	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kcd12_mouse(display_long)|uniprotkb:Pfetin(gene name synonym)|uniprotkb:Predominantly fetal expressed T1 domain(gene name synonym)|uniprotkb:Kctd12(gene name)|psi-mi:Kctd12(display_short)|uniprotkb:Pfet1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043235"(receptor complex)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051260"(protein homooligomerization)|mint:Q6WVG3|refseq:NP_808383.3|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:5S5rFCAvBhZVG47OqS29CXJxXP810090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P27659	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2526690|uniprotkb:O89071|uniprotkb:Q91VJ6|ensembl:ENSMUSP00000080354	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl3_mouse(display_long)|uniprotkb:Rpl3(gene name)|psi-mi:Rpl3(display_short)|uniprotkb:J1 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_038790.2|ensembl:ENSMUSG00000060036(gene)|ensembl:ENSMUST00000081650(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045202"(synapse)|go:"GO:0071353"(cellular response to interleukin-4)|interpro:IPR000597(Ribosomal protein L3)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR019926|mint:P27659|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:GrC8OWBLXBaBuOrzEOvyR6cid1A10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P56942	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26450331|ensembl:ENSMUSP00000044352|uniprotkb:Q9D220	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mch_mouse(display_long)|uniprotkb:Pmch(gene name)|psi-mi:Pmch(display_short)|uniprotkb:Mch(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000048621(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007631"(feeding behavior)|go:"GO:0009409"(response to cold)|go:"GO:0030354"(melanin-concentrating hormone activity)|go:"GO:0031777"(type 1 melanin-concentrating hormone receptor binding)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042756"(drinking behavior)|go:"GO:0045202"(synapse)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046005"(positive regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|interpro:IPR005456(Pre-pro melanin-concentrating hormone)|mint:P56942|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUSG00000035383(gene)|refseq:NP_084247.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:l3UbZeUaSJTBhc0jao6eg+D8Q4U10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9Z2C4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6271698|ensembl:ENSMUSP00000015358	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mtmr1_mouse(display_long)|uniprotkb:Mtmr1(gene name)|psi-mi:Mtmr1(display_short)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000015214(gene)|ensembl:ENSMUST00000015358(transcript)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0060304"(regulation of phosphatidylinositol dephosphorylation)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030564|interpro:IPR037857|mint:Q9Z2C4|reactome:R-MMU-1660499|reactome:R-MMU-9035034|interpro:IPR030587|refseq:NP_001300631.1|refseq:NP_001300632.1|refseq:NP_001300635.1|refseq:NP_001300636.1|refseq:NP_001300633.1|refseq:NP_058681.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:56bCYgR0woEm3PVMMp9TPGiLGcw10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6ZWV3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6261064|ensembl:ENSMUSP00000008826|ensembl:ENSMUSP00000082055|ensembl:ENSMUSP00000125806|uniprotkb:P45634|uniprotkb:Q5M9K8|uniprotkb:Q569M8	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl10_mouse(display_long)|uniprotkb:Protein QM homolog(gene name synonym)|uniprotkb:Qm(gene name synonym)|uniprotkb:Rpl10(gene name)|psi-mi:Rpl10(display_short)|uniprotkb:Ribosomal protein L10(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000008682(gene)|ensembl:ENSMUSG00000058443(gene)|ensembl:ENSMUST00000008826(transcript)|ensembl:ENSMUST00000074085(transcript)|ensembl:ENSMUST00000076364(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0097421"(liver regeneration)|go:"GO:1990403"(embryonic brain development)|interpro:IPR001197(Ribosomal protein L10e)|interpro:IPR016180(Ribosomal protein L10e/L16)|interpro:IPR018255|interpro:IPR036920|mint:Q6ZWV3|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|refseq:NP_443067.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:wJnBcv39yvVz2CaZq8UKgxIpJeE10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P11983	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-772338|uniprotkb:Q3TJ96|uniprotkb:Q3TKU1|uniprotkb:Q3U5T8|uniprotkb:Q3U7I8|uniprotkb:Q3UAA8|uniprotkb:Q3UB80|uniprotkb:Q3UE48|intact:EBI-2291308|uniprotkb:P11984|ensembl:ENSMUSP00000116108	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tcpa_mouse(display_long)|uniprotkb:CCT-alpha(gene name synonym)|uniprotkb:Tailless complex polypeptide 1B(gene name synonym)|uniprotkb:Tcp1(gene name)|psi-mi:Tcp1(display_short)|uniprotkb:Ccta(gene name synonym)|uniprotkb:Cct1(gene name synonym)|uniprotkb:Tailless complex polypeptide 1A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001277641.1|refseq:NP_038714.2|dip:DIP-32342N|ensembl:ENSMUSG00000068039(gene)|ensembl:ENSMUST00000151287(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0043209"(myelin sheath)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P11983|reactome:R-MMU-390471|reactome:R-MMU-5620922|reactome:R-MMU-6814122	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:mSINCow3H5FzUCTXpqwkI18OI9o10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P07934	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470873|ensembl:ENSMUSP00000026617	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:phkg1_mouse(display_long)|uniprotkb:Phkg1(gene name)|psi-mi:Phkg1(display_short)|uniprotkb:Phkg(gene name synonym)|uniprotkb:Phosphorylase kinase subunit gamma-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PHKG1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000026617(transcript)|go:"GO:0004689"(phosphorylase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR002291(Phosphorylase kinase, gamma catalytic subunit)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P07934|reactome:R-MMU-70221|ensembl:ENSMUSG00000025537(gene)|refseq:NP_035209.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:oWhiqhcqtIelRPU5Z0TI4T9lskc10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80X50	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11664310|uniprotkb:Q8BIT6|uniprotkb:Q8BIW4|uniprotkb:Q8BJ01|uniprotkb:Q8CIG7|uniprotkb:Q8K102|uniprotkb:Q9CRT6|ensembl:ENSMUSP00000143459	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ubp2l_mouse(display_long)|uniprotkb:Ubap2l(gene name)|psi-mi:Ubap2l(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001159455.1|refseq:NP_001159456.1|refseq:NP_001159457.1|refseq:NP_001159458.1|refseq:NP_082751.1|refseq:XP_006502235.1|ensembl:ENSMUSG00000042520(gene)|ensembl:ENSMUST00000196843(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031519"(PcG protein complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|mint:Q80X50|rcsb pdb:1WJ7	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ucHEy1MXF7PTEdwLChr6zAOqtcM10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O88520	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2552311|ensembl:ENSMUSP00000025932|ensembl:ENSMUSP00000127932|uniprotkb:Q8BVL0|uniprotkb:Q91VH8|uniprotkb:Q3UJH6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:shoc2_mouse(display_long)|uniprotkb:Shoc2(gene name)|psi-mi:Shoc2(display_short)|uniprotkb:Protein soc-2 homolog(gene name synonym)|uniprotkb:Protein sur-8 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_011245601.1|ensembl:ENSMUST00000169861(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027036|interpro:IPR032675|mint:O88520|reactome:R-MMU-5673000|ensembl:ENSMUST00000025932(transcript)|refseq:NP_001161977.1|refseq:NP_062632.2|ensembl:ENSMUSG00000024976(gene)|refseq:XP_017173749.1|refseq:XP_006527291.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:13L09X2HzmpTeJz7rnIC0y3aXc810090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6ZPY2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471828|ensembl:ENSMUSP00000001451|uniprotkb:Q497S2|uniprotkb:Q8R3S4	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:smg5_mouse(display_long)|uniprotkb:Smg5(gene name)|psi-mi:Smg5(display_short)|uniprotkb:Est1b(gene name synonym)|uniprotkb:Kiaa1089(gene name synonym)|uniprotkb:EST1-like protein B(gene name synonym)|uniprotkb:SMG-5 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000001415(gene)|ensembl:ENSMUST00000001451(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035303"(regulation of dephosphorylation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070034"(telomerase RNA binding)|interpro:IPR002716(PilT protein, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR018834|interpro:IPR019458|mint:Q6ZPY2|reactome:R-MMU-975957|go:"GO:0005634"(nucleus)|refseq:NP_839977.2	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Y/eR4EkJuk60zjw+G9ykyMKnU3I10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CQE8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-912160|ensembl:ENSMUSP00000022341	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rtraf_mouse(display_long)|uniprotkb:RTRAF(gene name)|psi-mi:RTRAF(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080804.1|ensembl:ENSMUSG00000021807(gene)|ensembl:ENSMUST00000022341(transcript)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:0072686"(mitotic spindle)|interpro:IPR019265|mint:Q9CQE8	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:AP73IJnWMs4jwKTGnIC+q1GcBRc10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TMK9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2735641|uniprotkb:O88991|uniprotkb:Q2YDV8|uniprotkb:Q68ED6|uniprotkb:Q80YV6|uniprotkb:Q8BGP1|uniprotkb:Q8C5K6|uniprotkb:Q8CGC2|uniprotkb:Q91ZR0|uniprotkb:Q99KU9|uniprotkb:Q9QYF4|ensembl:ENSMUSP00000133649	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:hnrpq_mouse(display_long)|uniprotkb:Syncrip(gene name)|psi-mi:Syncrip(display_short)|uniprotkb:Hnrpq(gene name synonym)|uniprotkb:Nsap1(gene name synonym)|uniprotkb:Nsap1l(gene name synonym)|uniprotkb:Synaptotagmin-binding, cytoplasmic RNA-interacting protein(gene name synonym)|uniprotkb:Glycine- and tyrosine-rich RNA-binding protein(gene name synonym)|uniprotkb:NS1-associated protein 1(gene name synonym)|uniprotkb:pp68(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001271257.1|refseq:NP_062640.2|refseq:NP_062770.1|refseq:NP_001298042.1|ensembl:ENSMUSG00000032423(gene)|ensembl:ENSMUST00000173801(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006397"(mRNA processing)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006535(HnRNP R and Q splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034544|interpro:IPR034548|interpro:IPR035979|interpro:IPR041337|mint:Q7TMK9	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Ljuz8koebOL7L9jFBaevQYHinzw10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9QZQ8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-3508334|uniprotkb:Q91VZ2|uniprotkb:Q9QZQ7|ensembl:ENSMUSP00000016081	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:h2ay_mouse(display_long)|uniprotkb:Macroh2a1(gene name)|psi-mi:Macroh2a1(display_short)|uniprotkb:H2A.y(gene name synonym)|uniprotkb:H2A/y(gene name synonym)|uniprotkb:H2afy(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001152985.1|refseq:NP_001152986.1|refseq:NP_001152987.1|refseq:NP_036145.1|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0001740"(Barr body)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045815"(epigenetic maintenance of chromatin in transcription-competent conformation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:1901837"(negative regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1902750"(negative regulation of cell cycle G2/M phase transition)|go:"GO:1902882"(regulation of response to oxidative stress)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:1902883"(negative regulation of response to oxidative stress)|go:"GO:0005730"(nucleolus)|go:"GO:1902884"(positive regulation of response to oxidative stress)|go:"GO:1903226"(positive regulation of endodermal cell differentiation)|go:"GO:1904815"(negative regulation of protein localization to chromosome, telomeric region)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002119(Histone H2A)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR007125(Histone core)|go:"GO:0005813"(centrosome)|interpro:IPR009072(Histone-fold)|interpro:IPR021171|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|interpro:IPR032454|go:"GO:0007549"(dosage compensation)|interpro:IPR035796|interpro:IPR043472|mint:Q9QZQ8|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0019216"(regulation of lipid metabolic process)|ensembl:ENSMUSG00000015937(gene)|ensembl:ENSMUST00000016081(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000182"(rDNA binding)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:70q7YQGYxyE7ZBq8e7oOsIUSY0810090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P13864	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-301927|uniprotkb:Q80ZU3|uniprotkb:Q9CSC6|uniprotkb:P97413|uniprotkb:Q9QXX6|ensembl:ENSMUSP00000004202	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dnmt1_mouse(display_long)|uniprotkb:Dnmt1(gene name)|psi-mi:Dnmt1(display_short)|uniprotkb:Dnmt(gene name synonym)|uniprotkb:Met1(gene name synonym)|uniprotkb:Uim(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase MmuI(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001186360.2|refseq:NP_001186361.1|refseq:NP_001186362.1|refseq:NP_034196.5|interpro:IPR031303|interpro:IPR043151|mint:P13864|rcsb pdb:3AV4|rcsb pdb:3AV5|rcsb pdb:3AV6|rcsb pdb:3PT6|rcsb pdb:3PT9|rcsb pdb:4DA4|rcsb pdb:5GUT|rcsb pdb:5GUV|rcsb pdb:5WY1|rcsb pdb:6W8V|rcsb pdb:6W8W|reactome:R-MMU-212300|reactome:R-MMU-4655427|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|ensembl:ENSMUST00000004202(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010424"(DNA methylation on cytosine within a CG sequence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0044026"(DNA hypermethylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046500"(S-adenosylmethionine metabolic process)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051718"("DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:0016458"(obsolete gene silencing)|ensembl:ENSMUSG00000004099(gene)|refseq:NP_001300940.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:JgHTnDhDn4nuU6ww3jXfDPq01xY10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:A2AF47	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16733818|ensembl:ENSMUSP00000033419|uniprotkb:Q5KTP7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:doc11_mouse(display_long)|uniprotkb:Activated Cdc42-associated guanine nucleotide exchange factor(gene name synonym)|uniprotkb:Zizimin-2(gene name synonym)|uniprotkb:Dock11(gene name)|psi-mi:Dock11(display_short)|uniprotkb:Ziz2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000031093(gene)|ensembl:ENSMUST00000033419(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021816|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR035892|interpro:IPR037809|interpro:IPR043161|interpro:IPR043162|mint:A2AF47|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-983231|refseq:NP_001009947.2	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Hj/RFYqY5pvpk7vrJ1VKTZ0K0e010090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P51432	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2606131|uniprotkb:Q3UIS0|ensembl:ENSMUSP00000025912	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:plcb3_mouse(display_long)|uniprotkb:Plcb3(gene name)|psi-mi:Plcb3(display_short)|uniprotkb:Phosphoinositide phospholipase C-beta-3(gene name synonym)|uniprotkb:Phospholipase C-beta-3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001277278.1|refseq:NP_032900.2|ensembl:ENSMUSG00000024960(gene)|ensembl:ENSMUST00000025912(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0032957"(inositol trisphosphate metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0031161"(phosphatidylinositol catabolic process)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0099524"(postsynaptic cytosol)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR011992(EF-Hand type)|interpro:IPR014815(PLC-beta, C-terminal)|interpro:IPR015359(Phospholipase C, phosphoinositol-specific, EF-hand-like)|interpro:IPR016280(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta)|interpro:IPR017946|interpro:IPR035892|interpro:IPR037862|interpro:IPR042531|mint:P51432|reactome:R-MMU-112043|reactome:R-MMU-1855204|reactome:R-MMU-399997|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-418217|reactome:R-MMU-434316|reactome:R-MMU-500657	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:QLv9VwdghXWe7hlfN9JAV23z9oU10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9D8E6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-773932|uniprotkb:Q9CY08|ensembl:ENSMUSP00000034966	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl4_mouse(display_long)|uniprotkb:Rpl4(gene name)|psi-mi:Rpl4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_077174.1|ensembl:ENSMUSG00000032399(gene)|ensembl:ENSMUST00000034966(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031672"(A band)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002136(Ribosomal protein L4/L1e)|interpro:IPR013000(Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site)|interpro:IPR023574|interpro:IPR025755|mint:Q9D8E6|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:qAUdFzxz+ZWX98r7PxtHQGtTXKw10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9D6S7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471110|ensembl:ENSMUSP00000028250|uniprotkb:B1B055	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rrfm_mouse(display_long)|uniprotkb:Mrrf(gene name)|psi-mi:Mrrf(display_short)|uniprotkb:Ribosome-releasing factor, mitochondrial(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000026887(gene)|ensembl:ENSMUST00000028250(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006412"(translation)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0043023"(ribosomal large subunit binding)|interpro:IPR002661(Ribosome recycling factor)|interpro:IPR023584|interpro:IPR036191|mint:Q9D6S7|rcsb pdb:1WIH|reactome:R-MMU-5419276|refseq:NP_080698.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:IZfaK7W9vh+OKt5CBZii+juKlo810090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3UGC7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-17170843|ensembl:ENSMUSP00000028668	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ei3ja_mouse(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 1-A(gene name synonym)|uniprotkb:eIF-3-alpha-A(gene name synonym)|uniprotkb:eIF3 p35(gene name synonym)|uniprotkb:Eif3j1(gene name)|psi-mi:Eif3j1(display_short)|uniprotkb:Eif3s1-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000027236(gene)|ensembl:ENSMUST00000028668(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042802"(identical protein binding)|interpro:IPR013906(Translation initiation factor eIF3 subunit)|interpro:IPR023194|mint:Q3UGC7|reactome:R-MMU-156827|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|refseq:NP_653128.2	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:eibVbzmFcJ5qAD797IS+jZFKxvE10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P26043	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-647737|uniprotkb:Q3TS85|uniprotkb:Q9QW27|ensembl:ENSMUSP00000000590|ensembl:ENSMUSP00000128249	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:radi_mouse(display_long)|uniprotkb:ESP10(gene name synonym)|uniprotkb:Rdx(gene name)|psi-mi:Rdx(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001098086.1|refseq:NP_033067.2|dip:DIP-29091N|ensembl:ENSMUSG00000032050(gene)|ensembl:ENSMUST00000000590(transcript)|ensembl:ENSMUST00000163153(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032231"(regulation of actin filament bundle assembly)|go:"GO:0032420"(stereocilium)|go:"GO:0034111"(negative regulation of homotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0045176"(apical protein localization)|go:"GO:0045177"(apical part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903392"(negative regulation of adherens junction organization)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P26043|rcsb pdb:1GC6|rcsb pdb:1GC7|rcsb pdb:1J19|rcsb pdb:2D10|rcsb pdb:2D11|rcsb pdb:2D2Q|rcsb pdb:2EMS|rcsb pdb:2EMT|rcsb pdb:2YVC|rcsb pdb:2ZPY|rcsb pdb:3X23|reactome:R-MMU-437239	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:d7wqsdTau9b92O3q6LW+/pyKL1w10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P39087	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-396914|uniprotkb:Q60933|ensembl:ENSMUSP00000101124|ensembl:ENSMUSP00000151921	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:grik2_mouse(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym)|uniprotkb:Glutamate receptor beta-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_017169293.1|ensembl:ENSMUSG00000056073(gene)|ensembl:ENSMUST00000105484(transcript)|ensembl:ENSMUST00000218823(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|mint:P39087|reactome:R-MMU-451307|reactome:R-MMU-451308	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:6sgY8SzX07HzilLLeDg3pV+sXkc10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TSH2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-911437|ensembl:ENSMUSP00000050788	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kpbb_mouse(display_long)|uniprotkb:Phkb(gene name)|psi-mi:Phkb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_955517.1|ensembl:ENSMUSG00000036879(gene)|ensembl:ENSMUST00000053771(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|interpro:IPR008734(Phosphorylase kinase alphabeta)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR011613(Glycoside hydrolase 15-related)|mint:Q7TSH2|reactome:R-MMU-70221|refseq:XP_006530595.1|refseq:XP_006530596.1|refseq:XP_006530597.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:qRovReuecws5KcJl6XVcnVO5FW410090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CC12	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470848|ensembl:ENSMUSP00000106329|uniprotkb:A2AW10|uniprotkb:Q149P8|uniprotkb:Q3U032	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cdan1_mouse(display_long)|uniprotkb:Cdan1(gene name)|psi-mi:Cdan1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000027284(gene)|ensembl:ENSMUST00000110701(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0008104"(protein localization)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031497"(chromatin assembly)|interpro:IPR028171|interpro:IPR040031|mint:Q8CC12|refseq:NP_081167.2	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:5Nyg/Fnh9WKYy3DFp/o8OTH4LGA10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P18826	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470825|ensembl:ENSMUSP00000061991|uniprotkb:A2AI90	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kpb1_mouse(display_long)|uniprotkb:Phka1(gene name)|psi-mi:Phka1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000034055(gene)|ensembl:ENSMUST00000052012(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR008734(Phosphorylase kinase alphabeta)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR011613(Glycoside hydrolase 15-related)|interpro:IPR012341(Six-hairpin glycosidase)|mint:P18826|reactome:R-MMU-70221|refseq:NP_032858.2	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:m6KkLpQv72gScTWLDJ2f1g4mtuo10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CXY6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2312782|uniprotkb:Q3U083|uniprotkb:Q5RKG0|uniprotkb:Q8CCY9|uniprotkb:Q99KS3|ensembl:ENSMUSP00000001042	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ilf2_mouse(display_long)|uniprotkb:Ilf2(gene name)|psi-mi:Ilf2(display_short)|uniprotkb:Nf45(gene name synonym)|uniprotkb:Nuclear factor of activated T-cells 45 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080650.1|ensembl:ENSMUSG00000001016(gene)|ensembl:ENSMUST00000001042(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR043519|mint:Q9CXY6|rcsb pdb:4AT7|rcsb pdb:4AT8|rcsb pdb:4AT9|rcsb pdb:4ATB|reactome:R-MMU-6798695	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:HwUDuY6Ev7csoTThxZCW8nJT88o10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q64105	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470795|uniprotkb:Q63996	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:spre_mouse(display_long)|uniprotkb:Spr(gene name)|psi-mi:Spr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0004757"(sepiapterin reductase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006558"(L-phenylalanine metabolic process)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0010033"(response to organic substance)|go:"GO:0019889"(pteridine metabolic process)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046146"(tetrahydrobiopterin metabolic process)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050882"(voluntary musculoskeletal movement)|rcsb pdb:1NAS|rcsb pdb:1OAA|rcsb pdb:1SEP|reactome:R-MMU-1474151|reactome:R-MMU-203615|mint:Q64105|interpro:IPR036291|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR006393(Sepiapterin reductase)	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Y4ePCWcq2RI0t59kgHibLyHd6yM10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9Z1X4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6260790|ensembl:ENSMUSP00000065770|uniprotkb:Q8BP80|uniprotkb:Q8K588|uniprotkb:Q8C2H8|uniprotkb:Q812A1|uniprotkb:Q80VD5	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ilf3_mouse(display_long)|uniprotkb:Ilf3(gene name)|psi-mi:Ilf3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001264250.1|ensembl:ENSMUSG00000032178(gene)|ensembl:ENSMUST00000067646(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006479"(protein methylation)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR033099|interpro:IPR043519|mint:Q9Z1X4|rcsb pdb:4AT7|rcsb pdb:4AT8|rcsb pdb:4AT9|rcsb pdb:4ATB|rcsb pdb:5DV7|refseq:XP_006510094.1|refseq:NP_001036172.1|refseq:NP_001036173.1|refseq:NP_034691.2|refseq:NP_001264251.1	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:vxZan3L6NAseX1Ib9Z7MQ82CM3E10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P11881	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-541478|uniprotkb:P20943|uniprotkb:Q99LG5|ensembl:ENSMUSP00000032192	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:itpr1_mouse(display_long)|uniprotkb:Type 1 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 1(gene name synonym)|uniprotkb:Inositol 1,4,5-trisphosphate-binding protein P400(gene name synonym)|uniprotkb:Purkinje cell protein 1(gene name synonym)|uniprotkb:Protein PCD-6(gene name synonym)|uniprotkb:Itpr1(gene name)|psi-mi:Itpr1(display_short)|uniprotkb:Insp3r(gene name synonym)|uniprotkb:Pcd6(gene name synonym)|uniprotkb:Pcp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_034715.3|refseq:XP_006505693.1|refseq:XP_006505699.1|refseq:XP_006505700.1|dip:DIP-32243N|refseq:XP_017176897.1|refseq:XP_017176899.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0098794"(postsynapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|mint:P11881|rcsb pdb:1N4K|rcsb pdb:1XZZ|rcsb pdb:5GUG|rcsb pdb:5X9Z|rcsb pdb:5XA0|rcsb pdb:5XA1|reactome:R-MMU-114508|reactome:R-MMU-139853|reactome:R-MMU-381676|reactome:R-MMU-418457|reactome:R-MMU-5578775|reactome:R-MMU-983695|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097421"(liver regeneration)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098695"(inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels)|go:"GO:0098793"(presynapse)|ensembl:ENSMUSG00000030102(gene)|ensembl:ENSMUST00000032192(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:O+LA4/Acwos+RNtyqL3IgAe/kkk10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6ZPR4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16728165|ensembl:ENSMUSP00000109809|uniprotkb:B2RUK3|uniprotkb:Q8C3E7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kcnt1_mouse(display_long)|uniprotkb:Kcnt1(gene name)|psi-mi:Kcnt1(display_short)|uniprotkb:Kiaa1422(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000058740(gene)|ensembl:ENSMUST00000114172(transcript)|go:"GO:0005228"(intracellular sodium activated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR013099(Ion transport 2)|mint:Q6ZPR4|refseq:NP_001289280.1|refseq:NP_780671.2	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:dqty8xDH9pIQhzgbYTeSOo4tLjA10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q08460	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O35099	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-777493|uniprotkb:Q14AY5|ensembl:ENSMUSP00000093485	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:m3k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:Map3k5(gene name)|psi-mi:Map3k5(display_short)|uniprotkb:Ask1(gene name synonym)|uniprotkb:Mekk5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472137|imex:IM-28526-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_032606.4|dip:DIP-38055N|ensembl:ENSMUSG00000071369(gene)|ensembl:ENSMUST00000095806(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010941"(regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902170"(cellular response to reactive nitrogen species)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:O35099|reactome:R-MMU-2559580	-	-	-	figure legend:ST2|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:"we used a SAINT score cutoff of ≥0.8 for isolations of Hdac4 in the whole brain for the Q20 2- and 10-month data and the Q140 2-month data (28). For the Q140 10-month data, we observed an overall increase in the number of proteins that passed this cutoff. Given the possibility that some of these interactions may derive non-specifically from the increased aggregation present in these symptomatic brains, we used a more stringent cutoff of ≥0.95 when analyzing these data."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:i1P8YtUNmpFauFUVVxzsMYoQYOw10090	rigid:a06C+hPFNqg/C6at+q09ZtJopPA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P28665	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8320382|intact:MINT-4102594|uniprotkb:Q3UNE7|intact:MINT-1862833|uniprotkb:Q80XE6|ensembl:ENSMUSP00000032228	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mug1_mouse(display_long)|uniprotkb:Mug1(gene name)|psi-mi:Mug1(display_short)|uniprotkb:Mug-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032671.2|ensembl:ENSMUSG00000059908(gene)|ensembl:ENSMUST00000032228(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007566"(embryo implantation)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR010916(TonB box, conserved site)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR019742|interpro:IPR036595|interpro:IPR040839|interpro:IPR041555|interpro:IPR041813|mint:P28665	-	-	function:A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective|comment:mint	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:zlCQxuDrGyWSoKUL6Iuuz5ZMi3w10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P19221	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8375972|intact:MINT-4137721|ensembl:ENSMUSP00000028681	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:thrb_mouse(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Cf2(gene name synonym)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_034298.1|dip:DIP-60968N|ensembl:ENSMUSG00000027249(gene)|ensembl:ENSMUST00000028681(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|interpro:IPR035972|interpro:IPR037111|interpro:IPR038178|interpro:IPR043504|mint:P19221|rcsb pdb:2OCV|rcsb pdb:2PUX|rcsb pdb:2PV9|rcsb pdb:3EDX|rcsb pdb:3HK3|rcsb pdb:3HK6|rcsb pdb:3HKI|reactome:R-MMU-140837|reactome:R-MMU-140875|reactome:R-MMU-159740|reactome:R-MMU-159763|reactome:R-MMU-159782|reactome:R-MMU-202733|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-456926|reactome:R-MMU-76009|reactome:R-MMU-977606	-	-	comment:mint|function:Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:amZ+Pl0pNliSHuykYcjQLfqb1vw10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q925E7	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8322442|intact:MINT-4086270|uniprotkb:Q6ZPN5|ensembl:ENSMUSP00000040321	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:2abd_mouse(display_long)|uniprotkb:Ppp2r2d(gene name)|psi-mi:Ppp2r2d(display_short)|uniprotkb:D7Ertd753e(gene name synonym)|uniprotkb:Kiaa1541(gene name synonym)|uniprotkb:PP2A subunit B isoform delta(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-delta(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-delta(gene name synonym)|uniprotkb:PP2A subunit B isoform R2-delta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_080667.1|ensembl:ENSMUSG00000041769(gene)|ensembl:ENSMUST00000041097(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005829"(cytosol)|go:"GO:0010458"(exit from mitosis)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0051301"(cell division)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:Q925E7	-	-	function:The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment|comment:mint	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Zh/H8rSp0CYazGt4SwUz+532bJQ10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P51660	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8328056|intact:MINT-1859569|intact:MINT-2512164|uniprotkb:Q9DBM3|ensembl:ENSMUSP00000025385	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:dhb4_mouse(display_long)|uniprotkb:Hsd17b4(gene name)|psi-mi:Hsd17b4(display_short)|uniprotkb:Edh17b4(gene name synonym)|uniprotkb:Multifunctional protein 2(gene name synonym)|uniprotkb:D-bifunctional protein(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032318.2|ensembl:ENSMUSG00000024507(gene)|ensembl:ENSMUST00000025385(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0004303"(estradiol 17-beta-dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0033989"(3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity)|go:"GO:0036111"(very long-chain fatty-acyl-CoA metabolic process)|go:"GO:0036112"(medium-chain fatty-acyl-CoA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0060009"(Sertoli cell development)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR002539(MaoC-like dehydratase)|interpro:IPR003033(Sterol-binding)|interpro:IPR020904|interpro:IPR029069|interpro:IPR036291|interpro:IPR036527|mint:P51660|reactome:R-MMU-193368|reactome:R-MMU-2046106|reactome:R-MMU-389887|reactome:R-MMU-390247|reactome:R-MMU-9033241	-	-	function:Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids|comment:mint	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:71hLYwG2pK+0vOd5eF+qYIa7J5I10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q921H8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8330006|intact:MINT-1858351|ensembl:ENSMUSP00000042351	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:thika_mouse(display_long)|uniprotkb:Acetyl-CoA C-myristoyltransferase(gene name synonym)|uniprotkb:Acaa1a(gene name)|psi-mi:Acaa1a(display_short)|uniprotkb:Acaa1(gene name synonym)|uniprotkb:Beta-ketothiolase A(gene name synonym)|uniprotkb:Acetyl-CoA acyltransferase A(gene name synonym)|uniprotkb:Peroxisomal 3-oxoacyl-CoA thiolase A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_570934.1|refseq:XP_006511986.1|ensembl:ENSMUSG00000036138(gene)|ensembl:ENSMUST00000039784(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008775"(acetate CoA-transferase activity)|go:"GO:0010124"(phenylacetate catabolic process)|go:"GO:0016401"(palmitoyl-CoA oxidase activity)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:Q921H8|reactome:R-MMU-2046106|reactome:R-MMU-390247|reactome:R-MMU-6798695|reactome:R-MMU-9033241	-	-	comment:mint	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:A7f6/enaS9RJZ+DDXxVXXa/9vTU10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8R4H2	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8046267|intact:MINT-1774761|uniprotkb:E9QPW9|uniprotkb:Q80U18|ensembl:ENSMUSP00000072547	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:arhgc_mouse(display_long)|uniprotkb:Arhgef12(gene name)|psi-mi:Arhgef12(display_short)|uniprotkb:Kiaa0382(gene name synonym)|uniprotkb:Larg(gene name synonym)|uniprotkb:Leukemia-associated RhoGEF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:XP_006510649.1|ensembl:ENSMUSG00000059495(gene)|ensembl:ENSMUST00000072767(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037801|interpro:IPR037884|interpro:IPR041020|mint:Q8R4H2|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148	-	-	comment:mint|function:"May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13"	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:5ZclDYjaUBilqiB548/6M5KlhVg10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9D4F8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-7780439|ensembl:ENSMUSP00000044049|intact:UNK-5542993	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp4_mouse(display_long)|uniprotkb:Tubgcp4(gene name)|psi-mi:Tubgcp4(display_short)|uniprotkb:D2Ertd435e(gene name synonym)|uniprotkb:Gcp4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000027263(gene)|ensembl:ENSMUST00000039541(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005813"(centrosome)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0055037"(recycling endosome)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|interpro:IPR042241|mint:Q9D4F8|reactome:R-MMU-380270|reactome:R-MMU-380320|go:"GO:0005874"(microtubule)|refseq:NP_700436.1	-	-	function:Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome|comment:mint	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:uoyvScV5OQTR+AqUMMIYMhe/a/Q10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q921G8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2552389|ensembl:ENSMUSP00000026547|uniprotkb:G5E859	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp2_mouse(display_long)|uniprotkb:Gcp2(gene name synonym)|uniprotkb:Tubgcp2(gene name)|psi-mi:Tubgcp2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001272936.1|ensembl:ENSMUSG00000025474(gene)|ensembl:ENSMUST00000026547(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0001764"(neuron migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007420"(brain development)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:Q921G8|reactome:R-MMU-380270|reactome:R-MMU-380320|go:"GO:0000923"(equatorial microtubule organizing center)|refseq:NP_598516.2	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:rWPzsdt3ECnxr+ksi4MaH7okQ+M10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P11087	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1634830|uniprotkb:Q53WT0|uniprotkb:Q60635|uniprotkb:Q61367|uniprotkb:Q61427|uniprotkb:Q63919|uniprotkb:Q6PCL3|uniprotkb:Q810J9|ensembl:ENSMUSP00000001547	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:co1a1_mouse(display_long)|uniprotkb:Col1a1(gene name)|psi-mi:Col1a1(display_short)|uniprotkb:Cola1(gene name synonym)|uniprotkb:Alpha-1 type I collagen(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_031768.2|ensembl:ENSMUSG00000001506(gene)|ensembl:ENSMUST00000001547(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0001958"(endochondral ossification)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005584"(collagen type I trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0015031"(protein transport)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032355"(response to estradiol)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034505"(tooth mineralization)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043588"(skin development)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044691"(tooth eruption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0051591"(response to cAMP)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071306"(cellular response to vitamin E)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902618"(cellular response to fluoride)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR008160(Collagen triple helix repeat)|mint:P11087|reactome:R-MMU-114604|reactome:R-MMU-1442490|reactome:R-MMU-1474244|reactome:R-MMU-1650814|reactome:R-MMU-198933|reactome:R-MMU-2022090|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-2214320|reactome:R-MMU-2243919|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-430116|reactome:R-MMU-75892|reactome:R-MMU-76009|reactome:R-MMU-8874081|reactome:R-MMU-8948216|go:"GO:0002020"(protease binding)	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:mZrc8e1VDJc4u6y4zXOj0glFj9410090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q3ULA2	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-896325|uniprotkb:Q3U0Q4|uniprotkb:Q571K6|uniprotkb:Q9QUI5|uniprotkb:Q9R1G7|uniprotkb:Q9Z159|ensembl:ENSMUSP00000070728	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fbw1a_mouse(display_long)|uniprotkb:Btrc(gene name)|psi-mi:Btrc(display_short)|uniprotkb:Fbw1(gene name synonym)|uniprotkb:Fbxw1(gene name synonym)|uniprotkb:Fwd1(gene name synonym)|uniprotkb:Kiaa4123(gene name synonym)|uniprotkb:Beta-TrCP protein E3RS-IkappaB(gene name synonym)|uniprotkb:Beta-transducin repeat-containing protein(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:HOS(gene name synonym)|uniprotkb:Ubiquitin ligase FWD1(gene name synonym)|uniprotkb:pIkappaB-E3 receptor subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001273394.1|refseq:NP_001273395.1|refseq:NP_001032847.2|refseq:NP_033901.1|ensembl:ENSMUSG00000025217(gene)|ensembl:ENSMUST00000065601(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q3ULA2	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:68Mr81ekjMZX2Tsp6Y+2XkN0MXA10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P35441	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-6171593	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tsp1_mouse(display_long)|uniprotkb:Thbs1(gene name)|psi-mi:Thbs1(display_short)|uniprotkb:Tsp1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0043236"(laminin binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|reactome:R-MMU-114608|reactome:R-MMU-186797|reactome:R-MMU-216083|reactome:R-MMU-5173214|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016477"(cell migration)|interpro:IPR001881(EGF-like calcium-binding)|mint:P35441|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR017897|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:0j9TPpvxNW9TNMFkFCNo+9wD3fA10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P20918	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-5607005|uniprotkb:Q8CIS2|uniprotkb:Q91WJ5|ensembl:ENSMUSP00000014578	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:plmn_mouse(display_long)|uniprotkb:Plg(gene name)|psi-mi:Plg(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032903.3|ensembl:ENSMUSG00000059481(gene)|ensembl:ENSMUST00000014578(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007596"(blood coagulation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042730"(fibrinolysis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048771"(tissue remodeling)|go:"GO:0051087"(chaperone binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0051919"(positive regulation of fibrinolysis)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071674"(mononuclear cell migration)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:1990405"(protein antigen binding)|interpro:IPR000001(Kringle)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003609(Apple-like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR018114|interpro:IPR023317|interpro:IPR033116|interpro:IPR038178|interpro:IPR043504|mint:P20918|reactome:R-MMU-114608|reactome:R-MMU-1474228|reactome:R-MMU-1592389|reactome:R-MMU-186797|reactome:R-MMU-75205|reactome:R-MMU-8964041	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:IOfMej57pCeThxfeTAXEGlU7Hy410090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P32020	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-309563|uniprotkb:Q9DBM7|uniprotkb:A2APS2|uniprotkb:A2APS3|ensembl:ENSMUSP00000030340	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:scp2_mouse(display_long)|uniprotkb:Scp2(gene name)|psi-mi:Scp2(display_short)|uniprotkb:Scp-2(gene name synonym)|uniprotkb:Propanoyl-CoA C-acyltransferase(gene name synonym)|uniprotkb:Sterol carrier protein X(gene name synonym)|uniprotkb:SCP-chi(gene name synonym)|uniprotkb:Acetyl-CoA C-myristoyltransferase(gene name synonym)|uniprotkb:Non-specific lipid-transfer protein(gene name synonym)|uniprotkb:SCP-2/3-oxoacyl-CoA thiolase(gene name synonym)|uniprotkb:SCP-2/thiolase(gene name synonym)|uniprotkb:Straight-chain acyl-CoA oxidase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035457.1|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006701"(progesterone biosynthetic process)|go:"GO:0007031"(peroxisome organization)|go:"GO:0007568"(aging)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008526"(phosphatidylinositol transfer activity)|go:"GO:0010893"(positive regulation of steroid biosynthetic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032385"(positive regulation of intracellular cholesterol transport)|go:"GO:0032934"(sterol binding)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033814"(propanoyl-CoA C-acyltransferase activity)|go:"GO:0036042"(long-chain fatty acyl-CoA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045940"(positive regulation of steroid metabolic process)|go:"GO:0050632"(propionyl-CoA C2-trimethyltridecanoyltransferase activity)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|go:"GO:0070538"(oleic acid binding)|go:"GO:0071071"(regulation of phospholipid biosynthetic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0120019"(phosphatidylcholine transfer activity)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1901373"(lipid hydroperoxide transport)|go:"GO:1904109"(positive regulation of cholesterol import)|go:"GO:1904121"(phosphatidylethanolamine transfer activity)|interpro:IPR003033(Sterol-binding)|interpro:IPR016039(Thiolase-like)|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|interpro:IPR036527|mint:P32020|go:"GO:0006637"(acyl-CoA metabolic process)|ensembl:ENSMUSG00000028603(gene)|ensembl:ENSMUST00000030340(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:IpeZbl/Hw0r6QueEBBV8WBaMnNM10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P09411	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1634776|uniprotkb:Q3TPE6|uniprotkb:Q3UKV8|uniprotkb:Q5XJE7|ensembl:ENSMUSP00000080302	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:pgk1_mouse(display_long)|uniprotkb:Pgk1(gene name)|psi-mi:Pgk1(display_short)|uniprotkb:Pgk-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032854.2|dip:DIP-51710N|ensembl:ENSMUSG00000062070(gene)|ensembl:ENSMUST00000081593(transcript)|go:"GO:0004618"(phosphoglycerate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0016310"(phosphorylation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031639"(plasminogen activation)|go:"GO:0043531"(ADP binding)|go:"GO:0045121"(membrane raft)|go:"GO:0047134"("protein-disulfide reductase (NAD(P)) activity")|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001576(Phosphoglycerate kinase)|interpro:IPR015824(Phosphoglycerate kinase, N-terminal)|interpro:IPR015911(Phosphoglycerate kinase, conserved site)|interpro:IPR036043|mint:P09411|rcsb pdb:4O3F|reactome:R-MMU-70171|reactome:R-MMU-70263	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:388hPtU1n0xYbopG53ZWslYTzuk10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P16546	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-911063|uniprotkb:A3KGU6|uniprotkb:Q8K380|uniprotkb:Q9CT05|uniprotkb:A3KGU8|ensembl:ENSMUSP00000092697	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:sptn1_mouse(display_long)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:Sptan1(gene name)|psi-mi:Sptan1(display_short)|uniprotkb:Spna2(gene name synonym)|uniprotkb:Spta2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	dip:DIP-37712N|ensembl:ENSMUSG00000057738(gene)|ensembl:ENSMUST00000095083(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005916"(fascia adherens)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030507"(spectrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032437"(cuticular plate)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:P16546|reactome:R-MMU-264870|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:UVB6Kv+PBlqDH3OLoGjxm5oYVPQ10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P08249	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-773487|uniprotkb:Q0QF44|uniprotkb:Q8CF79|uniprotkb:Q8R1P0|ensembl:ENSMUSP00000019323	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mdhm_mouse(display_long)|uniprotkb:Mdh2(gene name)|psi-mi:Mdh2(display_short)|uniprotkb:Mor1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032643.2|ensembl:ENSMUSG00000019179(gene)|ensembl:ENSMUST00000019323(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016020"(membrane)|go:"GO:0016615"(malate dehydrogenase activity)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043621"(protein self-association)|go:"GO:0046554"("malate dehydrogenase (NADP+) activity")|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010097(Malate dehydrogenase, NAD-dependent, eukaryotes and gamma proteobacteria)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P08249|reactome:R-MMU-70263|reactome:R-MMU-71403	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:KG/ilme6qKXuXKp3BqXC5kQ0dM410090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q5SRY7	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-11073522|uniprotkb:Q923H0|uniprotkb:Q3TLZ8|uniprotkb:Q3TGM9|uniprotkb:Q8K022|uniprotkb:Q8BY90|ensembl:ENSMUSP00000090893	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fbw1b_mouse(display_long)|uniprotkb:Fbxw11(gene name)|psi-mi:Fbxw11(display_short)|uniprotkb:Btrcp2(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:Fbw1b(gene name synonym)|uniprotkb:Fbxw1b(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001258276.1|refseq:NP_001258277.1|refseq:NP_001258278.1|refseq:NP_598776.1|ensembl:ENSMUSG00000020271(gene)|ensembl:ENSMUST00000093205(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048511"(rhythmic process)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q5SRY7|reactome:R-MMU-1169091|reactome:R-MMU-202424|reactome:R-MMU-2565942|reactome:R-MMU-2871837|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5676590|reactome:R-MMU-5684264|reactome:R-MMU-8951664|reactome:R-MMU-983168|dip:DIP-59921N	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:ahDg2ntR1uE9TEaFa8xgmsH3Ijg10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:E9Q557	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-688046|ensembl:ENSMUSP00000115062	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:desp_mouse(display_long)|uniprotkb:Dsp(gene name)|psi-mi:Dsp(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_076331.2|ensembl:ENSMUSG00000054889(gene)|ensembl:ENSMUST00000124830(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0002934"(desmosome organization)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030057"(desmosome)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042060"(wound healing)|go:"GO:0043588"(skin development)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0150105"(protein localization to cell-cell junction)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR028462|interpro:IPR035915|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:E9Q557|reactome:R-MMU-351906|reactome:R-MMU-6798695|reactome:R-MMU-6805567|reactome:R-MMU-6809371|reactome:R-MMU-9696264|reactome:R-MMU-9696273	-	-	comment:AfCS Y2H protein. Translated from nucleotide sequence.|comment:"Similar to DESP_HUMAN Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) (95%)"	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:AQF1MrZZW8M5RfagBI7P4b3qQPA10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P11276	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-641955|uniprotkb:G5E8B8|uniprotkb:Q61567|uniprotkb:Q61568|uniprotkb:Q61569|uniprotkb:Q64233|uniprotkb:Q80UI4|ensembl:ENSMUSP00000054499	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:finc_mouse(display_long)|uniprotkb:Fn1(gene name)|psi-mi:Fn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_034363.1|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P11276|rcsb pdb:1MFN|rcsb pdb:2MFN|reactome:R-MMU-114608|reactome:R-MMU-1474228|reactome:R-MMU-1474244|reactome:R-MMU-1566977|reactome:R-MMU-202733|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000170|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381426|reactome:R-MMU-5674135|reactome:R-MMU-8874081|reactome:R-MMU-8957275|ensembl:ENSMUSG00000026193(gene)|ensembl:ENSMUST00000055226(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005577"(fibrinogen complex)	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:qndGPG6vmzpIIkDuO1BrVRI1oPg10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9WV30	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472334|ensembl:ENSMUSP00000116094|uniprotkb:E9Q0P3|uniprotkb:E9Q6U2|uniprotkb:G5E8N9|uniprotkb:Q91WY0|uniprotkb:Q9JLA1	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:nfat5_mouse(display_long)|uniprotkb:Nfat5(gene name)|psi-mi:Nfat5(display_short)|uniprotkb:Rel domain-containing transcription factor NFAT5(gene name synonym)|uniprotkb:T-cell transcription factor NFAT5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000003847(gene)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0010628"(positive regulation of gene expression)|ensembl:ENSMUST00000125721(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|interpro:IPR011539(Rel homology)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0005634"(nucleus)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0005654"(nucleoplasm)|interpro:IPR015646(Nuclear factor of activated T-cells 5)|interpro:IPR032397|interpro:IPR037059|mint:Q9WV30|refseq:NP_001273189.1|refseq:NP_061293.2|refseq:NP_598718.2|refseq:XP_006531255.1|refseq:XP_017168393.1	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Yf1n8cmeTkVMCL5aw+LQZwrAIcM10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q91VN4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-776230|uniprotkb:Q3UNQ1|uniprotkb:Q9D5I5|uniprotkb:Q9DAM8|ensembl:ENSMUSP00000032172	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mic25_mouse(display_long)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 6(gene name synonym)|uniprotkb:Mic25(gene name synonym)|uniprotkb:Chchd6(gene name)|psi-mi:Chchd6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001161208.1|refseq:NP_079627.3|ensembl:ENSMUSG00000030086(gene)|ensembl:ENSMUST00000032172(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|interpro:IPR042860|mint:Q91VN4	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Op64pUsaaQVJ4d+W9vkGMMkgI8810090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P01027	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-4281083|uniprotkb:Q80XP1|ensembl:ENSMUSP00000024988|uniprotkb:Q61370	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:co3_mouse(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:HSE-MSF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000024164(gene)|ensembl:ENSMUST00000024988(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008289"(lipid binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01027|rcsb pdb:6XZU|reactome:R-MMU-173736|reactome:R-MMU-174577|reactome:R-MMU-198933|reactome:R-MMU-375276|reactome:R-MMU-381426|reactome:R-MMU-418594|reactome:R-MMU-6798695|reactome:R-MMU-8957275|reactome:R-MMU-977606|refseq:NP_033908.2	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:VGFRYhKETrS9O7cyeJZyxBFgBL410090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P52480	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-647785|uniprotkb:Q3TBV8|uniprotkb:Q3TBW5|uniprotkb:Q3TC59|uniprotkb:Q3U1X3|uniprotkb:Q3U5P6|uniprotkb:Q4VC20|uniprotkb:Q64484|uniprotkb:Q91YI8|uniprotkb:Q9CWB1|ensembl:ENSMUSP00000034834	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:kpym_mouse(display_long)|uniprotkb:Pkm(gene name)|psi-mi:Pkm(display_short)|uniprotkb:Pk3(gene name synonym)|uniprotkb:Pkm2(gene name synonym)|uniprotkb:Pykm(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035229.2|refseq:XP_006510918.1|refseq:NP_001240812.1|refseq:XP_011240975.1|dip:DIP-40536N|ensembl:ENSMUSG00000032294(gene)|ensembl:ENSMUST00000034834(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001889"(liver development)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042866"(pyruvate biosynthetic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043531"(ADP binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:1902912"(pyruvate kinase complex)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P52480|reactome:R-MMU-6798695|reactome:R-MMU-70171	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:SWQx3aPATcnlExhyy8afjcrB+xo10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9CQ25	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2552037|ensembl:ENSMUSP00000023351|ensembl:ENSMUSP00000113832	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mzt2_mouse(display_long)|uniprotkb:Fam128b(gene name synonym)|uniprotkb:Mozart2(gene name synonym)|uniprotkb:Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B(gene name synonym)|uniprotkb:Mzt2(gene name)|psi-mi:Mzt2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|interpro:IPR024332|ensembl:ENSMUSG00000022671(gene)|mint:Q9CQ25|reactome:R-MMU-380270|reactome:R-MMU-380320|ensembl:ENSMUST00000023351(transcript)|ensembl:ENSMUST00000117136(transcript)|refseq:NP_083630.1|refseq:XP_006522651.1	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:heL4NryOHurQ03jZtyHwM/D5Xe810090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9CQR4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-299825|ensembl:ENSMUSP00000006900	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:aco13_mouse(display_long)|uniprotkb:Acot13(gene name)|psi-mi:Acot13(display_short)|uniprotkb:Hotdog-fold thioesterase superfamily member 2(gene name synonym)|uniprotkb:Palmitoyl-CoA hydrolase(gene name synonym)|uniprotkb:Them2(gene name synonym)|uniprotkb:Thioesterase superfamily member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000006717(gene)|ensembl:ENSMUST00000006900(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR003736(Phenylacetic acid degradation-related protein)|interpro:IPR006683(Thioesterase superfamily)|interpro:IPR029069|interpro:IPR039298|mint:Q9CQR4|rcsb pdb:2CY9|reactome:R-MMU-77289|refseq:NP_080066.1	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:jMok2ZPtX2ETleMlnA+90d/FVxs10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q6P1F6	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-997427|ensembl:ENSMUSP00000086640	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:2aba_mouse(display_long)|uniprotkb:PP2A subunit B isoform alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-alpha(gene name synonym)|uniprotkb:Ppp2r2a(gene name)|psi-mi:Ppp2r2a(display_short)|uniprotkb:PP2A subunit B isoform R2-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001192117.1|refseq:NP_082308.1|ensembl:ENSMUSG00000022052(gene)|ensembl:ENSMUST00000089230(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0043278"(response to morphine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:Q6P1F6|reactome:R-MMU-2995383|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-975957	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:evS6klM2alZXtMthVsshKkrNgiA10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8BUR9	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2553237|ensembl:ENSMUSP00000037557	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mzt1_mouse(display_long)|uniprotkb:Mzt1(gene name)|psi-mi:Mzt1(display_short)|uniprotkb:Mozart1(gene name synonym)|uniprotkb:Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUST00000042662(transcript)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0033566"(gamma-tubulin complex localization)|go:"GO:0051415"(microtubule nucleation by interphase microtubule organizing center)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR022214|mint:Q8BUR9|reactome:R-MMU-380270|reactome:R-MMU-380320|ensembl:ENSMUSG00000033186(gene)|refseq:NP_780454.1	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:a686Bpxk37Kl0gKKTz14f6sq6s410090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P33215	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2366213|uniprotkb:Q6NXV3|uniprotkb:Q8BN12|uniprotkb:Q8BN86|uniprotkb:Q8BQL9|uniprotkb:Q9CWK2|ensembl:ENSMUSP00000020163	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:nedd1_mouse(display_long)|uniprotkb:Nedd1(gene name)|psi-mi:Nedd1(display_short)|uniprotkb:Nedd-1(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032708.2|ensembl:ENSMUSG00000019988(gene)|ensembl:ENSMUST00000020163(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000922"(spindle pole)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0031109"(microtubule polymerization or depolymerization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045177"(apical part of cell)|go:"GO:0051301"(cell division)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P33215|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:xBFWC64fRlKEVonqdYWgcVEPK0010090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P07724	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1183810|uniprotkb:Q3TV03|uniprotkb:Q61802|uniprotkb:Q8C7C7|uniprotkb:Q8C7H3|uniprotkb:Q8CG74|ensembl:ENSMUSP00000031314	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:albu_mouse(display_long)|uniprotkb:Alb(gene name)|psi-mi:Alb(display_short)|uniprotkb:Alb1(gene name synonym)|uniprotkb:Alb-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_033784.2|ensembl:ENSMUSG00000029368(gene)|ensembl:ENSMUST00000031314(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0019825"(oxygen binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0046010"(positive regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0051087"(chaperone binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072341"(modified amino acid binding)|go:"GO:0140272"(exogenous protein binding)|go:"GO:1903981"(enterobactin binding)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR020857|interpro:IPR020858|interpro:IPR021177|mint:P07724|reactome:R-MMU-114608|reactome:R-MMU-159418|reactome:R-MMU-189451|reactome:R-MMU-189483|reactome:R-MMU-2168880|reactome:R-MMU-381426|reactome:R-MMU-879518|reactome:R-MMU-8957275|reactome:R-MMU-8964058|reactome:R-MMU-9707564	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:R7zO/mB332rAl8J+WrXfsHzjSYs10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9QXL8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472305	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:ndk7_mouse(display_long)|uniprotkb:Nme7(gene name)|psi-mi:Nme7(display_short)|uniprotkb:nm23-M7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	reactome:R-MMU-380320|go:"GO:0003351"(epithelial cilium movement involved in extracellular fluid movement)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005813"(centrosome)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0060830"(ciliary receptor clustering involved in smoothened signaling pathway)|go:"GO:0060972"(left/right pattern formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|reactome:R-MMU-380270|mint:Q9QXL8|interpro:IPR034907|interpro:IPR036850|interpro:IPR011410(Nucleoside diphosphate kinase, NDK7)|interpro:IPR035525|interpro:IPR037993|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR006602(Region of unknown function DM10)	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:zkOjHmuz7jAgTi/5/MQYROLtVKg10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q3UHD3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472278|ensembl:ENSMUSP00000082694|uniprotkb:B9EKJ2|uniprotkb:Q7TPP7|uniprotkb:Q8CHD2|uniprotkb:Q9CY74	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mtus2_mouse(display_long)|uniprotkb:Mtus2(gene name)|psi-mi:Mtus2(display_short)|uniprotkb:Cazip(gene name synonym)|uniprotkb:Kiaa0774(gene name synonym)|uniprotkb:Tip150(gene name synonym)|uniprotkb:Cardiac zipper protein(gene name synonym)|uniprotkb:Microtubule plus-end tracking protein TIP150(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000029651(gene)|ensembl:ENSMUST00000085558(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR033339|mint:Q3UHD3|refseq:NP_084196.4|refseq:XP_006504953.1	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:42tgoThcDyvR8GE7irQd8rHlKL410090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8C0D4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472248|ensembl:ENSMUSP00000138585|uniprotkb:Q8BVP8	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:rhg12_mouse(display_long)|uniprotkb:Arhgap12(gene name)|psi-mi:Arhgap12(display_short)|uniprotkb:Rho-type GTPase-activating protein 12(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000041225(gene)|ensembl:ENSMUST00000182559(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035491|interpro:IPR036020|interpro:IPR036028|mint:Q8C0D4|rcsb pdb:6GVC|reactome:R-MMU-9013149|reactome:R-MMU-9013405|reactome:R-MMU-9013424|reactome:R-MMU-9035034|refseq:NP_001034781.1|refseq:NP_083553.2	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:daP4oZJo5g2WAFHv8quvfttZ0H810090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P54071	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-773401|uniprotkb:Q8C2R9|uniprotkb:Q9EQK1|ensembl:ENSMUSP00000103007	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:idhp_mouse(display_long)|uniprotkb:Oxalosuccinate decarboxylase(gene name synonym)|uniprotkb:"NADP(+)-specific ICDH"(gene name synonym)|uniprotkb:IDP(gene name synonym)|uniprotkb:ICD-M(gene name synonym)|uniprotkb:Idh2(gene name)|psi-mi:Idh2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_766599.2|ensembl:ENSMUSG00000030541(gene)|ensembl:ENSMUST00000107384(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004448"(isocitrate dehydrogenase activity)|go:"GO:0004450"("isocitrate dehydrogenase (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0006741"(NADP biosynthetic process)|go:"GO:0051287"(NAD binding)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:1903976"(negative regulation of glial cell migration)|go:"GO:1904465"(negative regulation of matrix metallopeptidase secretion)|interpro:IPR004790(Isocitrate dehydrogenase NADP-dependent, eukaryotic)|interpro:IPR019818|interpro:IPR024084|mint:P54071|rcsb pdb:5H3E|rcsb pdb:5H3F|reactome:R-MMU-2151201|reactome:R-MMU-71403	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:CkBZHIePaNGTtcgyqEf03oczVM010090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8BKN5	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-11075667|uniprotkb:Q8C083|uniprotkb:Q69Z75|uniprotkb:Q8BLJ9|uniprotkb:Q3U8X5|ensembl:ENSMUSP00000032627	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp5_mouse(display_long)|uniprotkb:Tubgcp5(gene name)|psi-mi:Tubgcp5(display_short)|uniprotkb:Kiaa1899(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_666302.2|ensembl:ENSMUSG00000033790(gene)|ensembl:ENSMUST00000032627(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008017"(microtubule binding)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|interpro:IPR042241|mint:Q8BKN5|reactome:R-MMU-380270|reactome:R-MMU-380320	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:1BOIJxOyERW8OOgl7YGHj9W2PMw10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:G5E8P0	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2554025|ensembl:ENSMUSP00000104977|intact:EBI-11600212|uniprotkb:Q6PFC6|uniprotkb:Q6ZPK3|uniprotkb:Q8BWI2	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp6_mouse(display_long)|uniprotkb:Tubgcp6(gene name)|psi-mi:Tubgcp6(display_short)|uniprotkb:Kiaa1669(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001156791.1|ensembl:ENSMUSG00000051786(gene)|ensembl:ENSMUST00000109353(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR042241|mint:G5E8P0|reactome:R-MMU-380270|reactome:R-MMU-380320|interpro:IPR041470	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:o8N6a4n0HmcfpjPF0YcWNZVH39c10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8VCK3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-17170916|ensembl:ENSMUSP00000045901	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tbg2_mouse(display_long)|uniprotkb:Gamma-2-tubulin(gene name synonym)|uniprotkb:Tubg2(gene name)|psi-mi:Tubg2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000045007(gene)|ensembl:ENSMUST00000043654(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|interpro:IPR000217(Tubulin)|interpro:IPR002454(Gamma tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q8VCK3|reactome:R-MMU-380270|reactome:R-MMU-380320|refseq:NP_598789.1	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:ebQHblMVkTKA8wnY1ae2fdPzx8I10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P83887	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2553410|ensembl:ENSMUSP00000048036|uniprotkb:Q9Z310	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tbg1_mouse(display_long)|uniprotkb:Tubg1(gene name)|psi-mi:Tubg1(display_short)|uniprotkb:Tubg(gene name synonym)|uniprotkb:Gamma-1-tubulin(gene name synonym)|uniprotkb:Gamma-tubulin complex component 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000035198(gene)|ensembl:ENSMUST00000043680(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005827"(polar microtubule)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005929"(cilium)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0055037"(recycling endosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000217(Tubulin)|interpro:IPR002454(Gamma tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|go:"GO:0005525"(GTP binding)|interpro:IPR037103|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518|mint:P83887|refseq:NP_598785.1	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:vuOzSmoj6s4iR1pV9zNfwxYjue810090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P58854	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2551135|ensembl:ENSMUSP00000000776|uniprotkb:Q6PDQ9	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp3_mouse(display_long)|uniprotkb:Gcp3(gene name synonym)|uniprotkb:Tubgcp3(gene name)|psi-mi:Tubgcp3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472391|imex:IM-28526-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	reactome:R-MMU-380320|ensembl:ENSMUSG00000000759(gene)|ensembl:ENSMUST00000000776(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005827"(polar microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:P58854|reactome:R-MMU-380270|refseq:NP_932148.1	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/12/04	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:qyzJzan6HpBMaAAOyhPM+94ecQA10090	rigid:ubqiq8A+B6IZNQuzAZ9A7xdvxBU	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P19221	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8375972|intact:MINT-4137721|ensembl:ENSMUSP00000028681	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:thrb_mouse(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Cf2(gene name synonym)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_034298.1|dip:DIP-60968N|ensembl:ENSMUSG00000027249(gene)|ensembl:ENSMUST00000028681(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|interpro:IPR035972|interpro:IPR037111|interpro:IPR038178|interpro:IPR043504|mint:P19221|rcsb pdb:2OCV|rcsb pdb:2PUX|rcsb pdb:2PV9|rcsb pdb:3EDX|rcsb pdb:3HK3|rcsb pdb:3HK6|rcsb pdb:3HKI|reactome:R-MMU-140837|reactome:R-MMU-140875|reactome:R-MMU-159740|reactome:R-MMU-159763|reactome:R-MMU-159782|reactome:R-MMU-202733|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-456926|reactome:R-MMU-76009|reactome:R-MMU-977606	-	-	comment:mint|function:Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:amZ+Pl0pNliSHuykYcjQLfqb1vw10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:O35490	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8362567|uniprotkb:Q3UEM1|uniprotkb:Q3UL72|intact:MINT-1870182|uniprotkb:Q561N0|ensembl:ENSMUSP00000096912|ensembl:ENSMUSP00000135956	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:bhmt1_mouse(display_long)|uniprotkb:Bhmt(gene name)|psi-mi:Bhmt(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_057877.1|ensembl:ENSMUSG00000069324(gene)|ensembl:ENSMUSG00000074768(gene)|ensembl:ENSMUST00000091776(transcript)|ensembl:ENSMUST00000099309(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0006577"(amino-acid betaine metabolic process)|go:"GO:0006579"(amino-acid betaine catabolic process)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047150"(betaine-homocysteine S-methyltransferase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071267"(L-methionine salvage)|interpro:IPR003726(Homocysteine S-methyltransferase)|interpro:IPR017226(Betaine--homocysteine S-methyltransferase, BHMT)|interpro:IPR036589|mint:O35490|reactome:R-MMU-1614635|reactome:R-MMU-6798163	-	-	comment:mint|function:Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:llOjFBtpVqQ0VykdivCaaJKrwl810090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q921H8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8330006|intact:MINT-1858351|ensembl:ENSMUSP00000042351	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:thika_mouse(display_long)|uniprotkb:Acetyl-CoA C-myristoyltransferase(gene name synonym)|uniprotkb:Acaa1a(gene name)|psi-mi:Acaa1a(display_short)|uniprotkb:Acaa1(gene name synonym)|uniprotkb:Beta-ketothiolase A(gene name synonym)|uniprotkb:Acetyl-CoA acyltransferase A(gene name synonym)|uniprotkb:Peroxisomal 3-oxoacyl-CoA thiolase A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_570934.1|refseq:XP_006511986.1|ensembl:ENSMUSG00000036138(gene)|ensembl:ENSMUST00000039784(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008775"(acetate CoA-transferase activity)|go:"GO:0010124"(phenylacetate catabolic process)|go:"GO:0016401"(palmitoyl-CoA oxidase activity)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:Q921H8|reactome:R-MMU-2046106|reactome:R-MMU-390247|reactome:R-MMU-6798695|reactome:R-MMU-9033241	-	-	comment:mint	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:A7f6/enaS9RJZ+DDXxVXXa/9vTU10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P51660	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8328056|intact:MINT-1859569|intact:MINT-2512164|uniprotkb:Q9DBM3|ensembl:ENSMUSP00000025385	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:dhb4_mouse(display_long)|uniprotkb:Hsd17b4(gene name)|psi-mi:Hsd17b4(display_short)|uniprotkb:Edh17b4(gene name synonym)|uniprotkb:Multifunctional protein 2(gene name synonym)|uniprotkb:D-bifunctional protein(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032318.2|ensembl:ENSMUSG00000024507(gene)|ensembl:ENSMUST00000025385(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0004303"(estradiol 17-beta-dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0033989"(3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity)|go:"GO:0036111"(very long-chain fatty-acyl-CoA metabolic process)|go:"GO:0036112"(medium-chain fatty-acyl-CoA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0060009"(Sertoli cell development)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR002539(MaoC-like dehydratase)|interpro:IPR003033(Sterol-binding)|interpro:IPR020904|interpro:IPR029069|interpro:IPR036291|interpro:IPR036527|mint:P51660|reactome:R-MMU-193368|reactome:R-MMU-2046106|reactome:R-MMU-389887|reactome:R-MMU-390247|reactome:R-MMU-9033241	-	-	function:Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids|comment:mint	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:71hLYwG2pK+0vOd5eF+qYIa7J5I10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8R4H2	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8046267|intact:MINT-1774761|uniprotkb:E9QPW9|uniprotkb:Q80U18|ensembl:ENSMUSP00000072547	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:arhgc_mouse(display_long)|uniprotkb:Arhgef12(gene name)|psi-mi:Arhgef12(display_short)|uniprotkb:Kiaa0382(gene name synonym)|uniprotkb:Larg(gene name synonym)|uniprotkb:Leukemia-associated RhoGEF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:XP_006510649.1|ensembl:ENSMUSG00000059495(gene)|ensembl:ENSMUST00000072767(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037801|interpro:IPR037884|interpro:IPR041020|mint:Q8R4H2|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148	-	-	comment:mint|function:"May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13"	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:5ZclDYjaUBilqiB548/6M5KlhVg10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9D4F8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-7780439|ensembl:ENSMUSP00000044049|intact:UNK-5542993	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp4_mouse(display_long)|uniprotkb:Tubgcp4(gene name)|psi-mi:Tubgcp4(display_short)|uniprotkb:D2Ertd435e(gene name synonym)|uniprotkb:Gcp4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000027263(gene)|ensembl:ENSMUST00000039541(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005813"(centrosome)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0055037"(recycling endosome)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|interpro:IPR042241|mint:Q9D4F8|reactome:R-MMU-380270|reactome:R-MMU-380320|go:"GO:0005874"(microtubule)|refseq:NP_700436.1	-	-	function:Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome|comment:mint	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:uoyvScV5OQTR+AqUMMIYMhe/a/Q10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9R0L6	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-4284371|uniprotkb:O70287|uniprotkb:Q3URH6|uniprotkb:Q7TMS7|uniprotkb:Q8C9V2|uniprotkb:Q91Y27|uniprotkb:Q91Y28|uniprotkb:Q91Y51|uniprotkb:Q9CRK8|uniprotkb:Q923L0|uniprotkb:Q9CT57|uniprotkb:E9QLK2|ensembl:ENSMUSP00000039709	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:pcm1_mouse(display_long)|uniprotkb:Pcm1(gene name)|psi-mi:Pcm1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_076151.2|refseq:XP_006509361.1|ensembl:ENSMUSG00000031592(gene)|ensembl:ENSMUST00000045218(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q9R0L6|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-5620912|reactome:R-MMU-8854518|reactome:R-MMU-380320	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:OT+ZOQY5pqQojMcLCWMIY+6zdl410090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P20918	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-5607005|uniprotkb:Q8CIS2|uniprotkb:Q91WJ5|ensembl:ENSMUSP00000014578	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:plmn_mouse(display_long)|uniprotkb:Plg(gene name)|psi-mi:Plg(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032903.3|ensembl:ENSMUSG00000059481(gene)|ensembl:ENSMUST00000014578(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007596"(blood coagulation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042730"(fibrinolysis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048771"(tissue remodeling)|go:"GO:0051087"(chaperone binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0051919"(positive regulation of fibrinolysis)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071674"(mononuclear cell migration)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:1990405"(protein antigen binding)|interpro:IPR000001(Kringle)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003609(Apple-like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR018114|interpro:IPR023317|interpro:IPR033116|interpro:IPR038178|interpro:IPR043504|mint:P20918|reactome:R-MMU-114608|reactome:R-MMU-1474228|reactome:R-MMU-1592389|reactome:R-MMU-186797|reactome:R-MMU-75205|reactome:R-MMU-8964041	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:IOfMej57pCeThxfeTAXEGlU7Hy410090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P08249	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-773487|uniprotkb:Q0QF44|uniprotkb:Q8CF79|uniprotkb:Q8R1P0|ensembl:ENSMUSP00000019323	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mdhm_mouse(display_long)|uniprotkb:Mdh2(gene name)|psi-mi:Mdh2(display_short)|uniprotkb:Mor1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032643.2|ensembl:ENSMUSG00000019179(gene)|ensembl:ENSMUST00000019323(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016020"(membrane)|go:"GO:0016615"(malate dehydrogenase activity)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043621"(protein self-association)|go:"GO:0046554"("malate dehydrogenase (NADP+) activity")|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010097(Malate dehydrogenase, NAD-dependent, eukaryotes and gamma proteobacteria)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P08249|reactome:R-MMU-70263|reactome:R-MMU-71403	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:KG/ilme6qKXuXKp3BqXC5kQ0dM410090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9WUR2	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2794295|uniprotkb:Q99M61|uniprotkb:Q9D785|ensembl:ENSMUSP00000131735	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:eci2_mouse(display_long)|uniprotkb:Eci2(gene name)|psi-mi:Eci2(display_short)|uniprotkb:Dodecenoyl-CoA isomerase(gene name synonym)|uniprotkb:"Delta(3),delta(2)-enoyl-CoA isomerase"(gene name synonym)|uniprotkb:Peci(gene name synonym)|uniprotkb:Peroxisomal 3,2-trans-enoyl-CoA isomerase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001103801.1|refseq:NP_035998.2|refseq:XP_006516736.1|refseq:XP_006516737.1|refseq:XP_006516738.1|refseq:XP_006516739.1|refseq:XP_006516740.1|ensembl:ENSMUSG00000021417(gene)|ensembl:ENSMUST00000171229(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0004165"("delta(3)-delta(2)-enoyl-CoA isomerase activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0016863"(intramolecular oxidoreductase activity, transposing C=C bonds)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000582(Acyl-CoA-binding protein, ACBP)|interpro:IPR001753(Crotonase, core)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR022408|interpro:IPR029045|interpro:IPR035984|mint:Q9WUR2|reactome:R-MMU-390247|reactome:R-MMU-9033241|go:"GO:0006635"(fatty acid beta-oxidation)	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:nHPcS0mXXHwtPjuxHZLEOsf99sk10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:E9Q8I9	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-16732044|ensembl:ENSMUSP00000084454|uniprotkb:Q4VA57|uniprotkb:Q5DTL4|uniprotkb:Q8BIW6|uniprotkb:Q8BUA0|uniprotkb:Q8CG91	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fry_mouse(display_long)|uniprotkb:Fry(gene name)|psi-mi:Fry(display_short)|uniprotkb:Kiaa4143(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000056602(gene)|ensembl:ENSMUST00000087204(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005938"(cell cortex)|go:"GO:0030427"(site of polarized growth)|go:"GO:0031175"(neuron projection development)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025481|interpro:IPR025614|interpro:IPR029473|interpro:IPR039867|mint:E9Q8I9|refseq:NP_766475.2|refseq:XP_006504993.1	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:fvduzhqkwcM9qmnWvPWAA1W8HqI10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q5SRY7	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-11073522|uniprotkb:Q923H0|uniprotkb:Q3TLZ8|uniprotkb:Q3TGM9|uniprotkb:Q8K022|uniprotkb:Q8BY90|ensembl:ENSMUSP00000090893	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fbw1b_mouse(display_long)|uniprotkb:Fbxw11(gene name)|psi-mi:Fbxw11(display_short)|uniprotkb:Btrcp2(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:Fbw1b(gene name synonym)|uniprotkb:Fbxw1b(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001258276.1|refseq:NP_001258277.1|refseq:NP_001258278.1|refseq:NP_598776.1|ensembl:ENSMUSG00000020271(gene)|ensembl:ENSMUST00000093205(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048511"(rhythmic process)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q5SRY7|reactome:R-MMU-1169091|reactome:R-MMU-202424|reactome:R-MMU-2565942|reactome:R-MMU-2871837|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5676590|reactome:R-MMU-5684264|reactome:R-MMU-8951664|reactome:R-MMU-983168|dip:DIP-59921N	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:ahDg2ntR1uE9TEaFa8xgmsH3Ijg10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q7TSF1	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-6877235|ensembl:ENSMUSP00000076026|uniprotkb:Q7TQ60	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:dsg1b_mouse(display_long)|uniprotkb:Dsg1b(gene name)|psi-mi:Dsg1b(display_short)|uniprotkb:Dsg5(gene name synonym)|uniprotkb:Desmoglein-5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000061928(gene)|ensembl:ENSMUST00000076737(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0030057"(desmosome)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR009122(Desmosomal cadherin)|interpro:IPR009123(Desmoglein)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|mint:Q7TSF1|refseq:NP_859010.1	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:VsNieIP3TNuJAEFWaTF+KHWrXUQ10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P17183	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1634308|ensembl:ENSMUSP00000004378	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:enog_mouse(display_long)|uniprotkb:Eno2(gene name)|psi-mi:Eno2(display_short)|uniprotkb:Eno-2(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Neural enolase(gene name synonym)|uniprotkb:Neuron-specific enolase(gene name synonym)|uniprotkb:Enolase 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_038537.1|refseq:NP_001289571.1|refseq:XP_006505566.1|refseq:XP_006505567.1|ensembl:ENSMUSG00000004267(gene)|ensembl:ENSMUST00000004378(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030426"(growth cone)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0097060"(synaptic membrane)|go:"GO:0099738"(cell cortex region)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P17183|reactome:R-MMU-70171|reactome:R-MMU-70263	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:bEXS2/h1idLiCLtUPFHMwtCMV5I10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P62962	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-647096|uniprotkb:P10924|ensembl:ENSMUSP00000018437	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:prof1_mouse(display_long)|uniprotkb:Profilin I(gene name synonym)|uniprotkb:Pfn1(gene name)|psi-mi:Pfn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035202.1|dip:DIP-38075N|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050821"(protein stabilization)|go:"GO:0051054"(positive regulation of DNA metabolic process)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060074"(synapse maturation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR005454(Profilin, Mammalian)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR029892|interpro:IPR036140|mint:P62962|reactome:R-MMU-376176|reactome:R-MMU-4086400|reactome:R-MMU-5663220|ensembl:ENSMUSG00000018293(gene)|ensembl:ENSMUST00000018437(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:nzOTw5XdywGrh+fA9AInGIexyGk10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9WV30	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472334|ensembl:ENSMUSP00000116094|uniprotkb:E9Q0P3|uniprotkb:E9Q6U2|uniprotkb:G5E8N9|uniprotkb:Q91WY0|uniprotkb:Q9JLA1	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:nfat5_mouse(display_long)|uniprotkb:Nfat5(gene name)|psi-mi:Nfat5(display_short)|uniprotkb:Rel domain-containing transcription factor NFAT5(gene name synonym)|uniprotkb:T-cell transcription factor NFAT5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000003847(gene)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0010628"(positive regulation of gene expression)|ensembl:ENSMUST00000125721(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|interpro:IPR011539(Rel homology)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0005634"(nucleus)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0005654"(nucleoplasm)|interpro:IPR015646(Nuclear factor of activated T-cells 5)|interpro:IPR032397|interpro:IPR037059|mint:Q9WV30|refseq:NP_001273189.1|refseq:NP_061293.2|refseq:NP_598718.2|refseq:XP_006531255.1|refseq:XP_017168393.1	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Yf1n8cmeTkVMCL5aw+LQZwrAIcM10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P35441	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-6171593	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tsp1_mouse(display_long)|uniprotkb:Thbs1(gene name)|psi-mi:Thbs1(display_short)|uniprotkb:Tsp1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0043236"(laminin binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|reactome:R-MMU-114608|reactome:R-MMU-186797|reactome:R-MMU-216083|reactome:R-MMU-5173214|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016477"(cell migration)|interpro:IPR001881(EGF-like calcium-binding)|mint:P35441|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR017897|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:0j9TPpvxNW9TNMFkFCNo+9wD3fA10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P33215	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2366213|uniprotkb:Q6NXV3|uniprotkb:Q8BN12|uniprotkb:Q8BN86|uniprotkb:Q8BQL9|uniprotkb:Q9CWK2|ensembl:ENSMUSP00000020163	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:nedd1_mouse(display_long)|uniprotkb:Nedd1(gene name)|psi-mi:Nedd1(display_short)|uniprotkb:Nedd-1(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032708.2|ensembl:ENSMUSG00000019988(gene)|ensembl:ENSMUST00000020163(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000922"(spindle pole)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0031109"(microtubule polymerization or depolymerization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045177"(apical part of cell)|go:"GO:0051301"(cell division)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P33215|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:xBFWC64fRlKEVonqdYWgcVEPK0010090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P11276	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-641955|uniprotkb:G5E8B8|uniprotkb:Q61567|uniprotkb:Q61568|uniprotkb:Q61569|uniprotkb:Q64233|uniprotkb:Q80UI4|ensembl:ENSMUSP00000054499	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:finc_mouse(display_long)|uniprotkb:Fn1(gene name)|psi-mi:Fn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_034363.1|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P11276|rcsb pdb:1MFN|rcsb pdb:2MFN|reactome:R-MMU-114608|reactome:R-MMU-1474228|reactome:R-MMU-1474244|reactome:R-MMU-1566977|reactome:R-MMU-202733|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000170|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381426|reactome:R-MMU-5674135|reactome:R-MMU-8874081|reactome:R-MMU-8957275|ensembl:ENSMUSG00000026193(gene)|ensembl:ENSMUST00000055226(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005577"(fibrinogen complex)	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:qndGPG6vmzpIIkDuO1BrVRI1oPg10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P01027	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-4281083|uniprotkb:Q80XP1|ensembl:ENSMUSP00000024988|uniprotkb:Q61370	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:co3_mouse(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:HSE-MSF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000024164(gene)|ensembl:ENSMUST00000024988(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008289"(lipid binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01027|rcsb pdb:6XZU|reactome:R-MMU-173736|reactome:R-MMU-174577|reactome:R-MMU-198933|reactome:R-MMU-375276|reactome:R-MMU-381426|reactome:R-MMU-418594|reactome:R-MMU-6798695|reactome:R-MMU-8957275|reactome:R-MMU-977606|refseq:NP_033908.2	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:VGFRYhKETrS9O7cyeJZyxBFgBL410090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P17182	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-299507|ensembl:ENSMUSP00000075513|ensembl:ENSMUSP00000079727|ensembl:ENSMUSP00000157807|uniprotkb:Q99KT7|uniprotkb:Q9DCY7	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:enoa_mouse(display_long)|uniprotkb:Eno1(gene name)|psi-mi:Eno1(display_short)|uniprotkb:Eno-1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000059040(gene)|ensembl:ENSMUSG00000063524(gene)|ensembl:ENSMUST00000076155(transcript)|ensembl:ENSMUST00000080926(transcript)|ensembl:ENSMUST00000235307(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030426"(growth cone)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051020"(GTPase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0099738"(cell cortex region)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P17182|reactome:R-MMU-70171|reactome:R-MMU-70263|refseq:NP_001020559.1|refseq:NP_075608.2|refseq:XP_006538588.2	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:YFpn/7GDB6vXgCYLSxvNns7FlT410090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q91VN4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-776230|uniprotkb:Q3UNQ1|uniprotkb:Q9D5I5|uniprotkb:Q9DAM8|ensembl:ENSMUSP00000032172	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mic25_mouse(display_long)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 6(gene name synonym)|uniprotkb:Mic25(gene name synonym)|uniprotkb:Chchd6(gene name)|psi-mi:Chchd6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001161208.1|refseq:NP_079627.3|ensembl:ENSMUSG00000030086(gene)|ensembl:ENSMUST00000032172(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|interpro:IPR042860|mint:Q91VN4	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Op64pUsaaQVJ4d+W9vkGMMkgI8810090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:E9Q557	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-688046|ensembl:ENSMUSP00000115062	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:desp_mouse(display_long)|uniprotkb:Dsp(gene name)|psi-mi:Dsp(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_076331.2|ensembl:ENSMUSG00000054889(gene)|ensembl:ENSMUST00000124830(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0002934"(desmosome organization)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030057"(desmosome)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042060"(wound healing)|go:"GO:0043588"(skin development)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0150105"(protein localization to cell-cell junction)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR028462|interpro:IPR035915|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:E9Q557|reactome:R-MMU-351906|reactome:R-MMU-6798695|reactome:R-MMU-6805567|reactome:R-MMU-6809371|reactome:R-MMU-9696264|reactome:R-MMU-9696273	-	-	comment:AfCS Y2H protein. Translated from nucleotide sequence.|comment:"Similar to DESP_HUMAN Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) (95%)"	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:AQF1MrZZW8M5RfagBI7P4b3qQPA10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P52480	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-647785|uniprotkb:Q3TBV8|uniprotkb:Q3TBW5|uniprotkb:Q3TC59|uniprotkb:Q3U1X3|uniprotkb:Q3U5P6|uniprotkb:Q4VC20|uniprotkb:Q64484|uniprotkb:Q91YI8|uniprotkb:Q9CWB1|ensembl:ENSMUSP00000034834	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:kpym_mouse(display_long)|uniprotkb:Pkm(gene name)|psi-mi:Pkm(display_short)|uniprotkb:Pk3(gene name synonym)|uniprotkb:Pkm2(gene name synonym)|uniprotkb:Pykm(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035229.2|refseq:XP_006510918.1|refseq:NP_001240812.1|refseq:XP_011240975.1|dip:DIP-40536N|ensembl:ENSMUSG00000032294(gene)|ensembl:ENSMUST00000034834(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001889"(liver development)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042866"(pyruvate biosynthetic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043531"(ADP binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:1902912"(pyruvate kinase complex)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P52480|reactome:R-MMU-6798695|reactome:R-MMU-70171	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:SWQx3aPATcnlExhyy8afjcrB+xo10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9CQ25	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2552037|ensembl:ENSMUSP00000023351|ensembl:ENSMUSP00000113832	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mzt2_mouse(display_long)|uniprotkb:Fam128b(gene name synonym)|uniprotkb:Mozart2(gene name synonym)|uniprotkb:Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B(gene name synonym)|uniprotkb:Mzt2(gene name)|psi-mi:Mzt2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|interpro:IPR024332|ensembl:ENSMUSG00000022671(gene)|mint:Q9CQ25|reactome:R-MMU-380270|reactome:R-MMU-380320|ensembl:ENSMUST00000023351(transcript)|ensembl:ENSMUST00000117136(transcript)|refseq:NP_083630.1|refseq:XP_006522651.1	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:heL4NryOHurQ03jZtyHwM/D5Xe810090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9CQR4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-299825|ensembl:ENSMUSP00000006900	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:aco13_mouse(display_long)|uniprotkb:Acot13(gene name)|psi-mi:Acot13(display_short)|uniprotkb:Hotdog-fold thioesterase superfamily member 2(gene name synonym)|uniprotkb:Palmitoyl-CoA hydrolase(gene name synonym)|uniprotkb:Them2(gene name synonym)|uniprotkb:Thioesterase superfamily member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000006717(gene)|ensembl:ENSMUST00000006900(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR003736(Phenylacetic acid degradation-related protein)|interpro:IPR006683(Thioesterase superfamily)|interpro:IPR029069|interpro:IPR039298|mint:Q9CQR4|rcsb pdb:2CY9|reactome:R-MMU-77289|refseq:NP_080066.1	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:jMok2ZPtX2ETleMlnA+90d/FVxs10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q6P1F6	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-997427|ensembl:ENSMUSP00000086640	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:2aba_mouse(display_long)|uniprotkb:PP2A subunit B isoform alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-alpha(gene name synonym)|uniprotkb:Ppp2r2a(gene name)|psi-mi:Ppp2r2a(display_short)|uniprotkb:PP2A subunit B isoform R2-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001192117.1|refseq:NP_082308.1|ensembl:ENSMUSG00000022052(gene)|ensembl:ENSMUST00000089230(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0043278"(response to morphine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:Q6P1F6|reactome:R-MMU-2995383|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-975957	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:evS6klM2alZXtMthVsshKkrNgiA10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8BUR9	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2553237|ensembl:ENSMUSP00000037557	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mzt1_mouse(display_long)|uniprotkb:Mzt1(gene name)|psi-mi:Mzt1(display_short)|uniprotkb:Mozart1(gene name synonym)|uniprotkb:Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUST00000042662(transcript)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0033566"(gamma-tubulin complex localization)|go:"GO:0051415"(microtubule nucleation by interphase microtubule organizing center)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR022214|mint:Q8BUR9|reactome:R-MMU-380270|reactome:R-MMU-380320|ensembl:ENSMUSG00000033186(gene)|refseq:NP_780454.1	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:a686Bpxk37Kl0gKKTz14f6sq6s410090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9QXL8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472305	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:ndk7_mouse(display_long)|uniprotkb:Nme7(gene name)|psi-mi:Nme7(display_short)|uniprotkb:nm23-M7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	reactome:R-MMU-380320|go:"GO:0003351"(epithelial cilium movement involved in extracellular fluid movement)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005813"(centrosome)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0060830"(ciliary receptor clustering involved in smoothened signaling pathway)|go:"GO:0060972"(left/right pattern formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|reactome:R-MMU-380270|mint:Q9QXL8|interpro:IPR034907|interpro:IPR036850|interpro:IPR011410(Nucleoside diphosphate kinase, NDK7)|interpro:IPR035525|interpro:IPR037993|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR006602(Region of unknown function DM10)	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:zkOjHmuz7jAgTi/5/MQYROLtVKg10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q3UHD3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472278|ensembl:ENSMUSP00000082694|uniprotkb:B9EKJ2|uniprotkb:Q7TPP7|uniprotkb:Q8CHD2|uniprotkb:Q9CY74	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mtus2_mouse(display_long)|uniprotkb:Mtus2(gene name)|psi-mi:Mtus2(display_short)|uniprotkb:Cazip(gene name synonym)|uniprotkb:Kiaa0774(gene name synonym)|uniprotkb:Tip150(gene name synonym)|uniprotkb:Cardiac zipper protein(gene name synonym)|uniprotkb:Microtubule plus-end tracking protein TIP150(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000029651(gene)|ensembl:ENSMUST00000085558(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR033339|mint:Q3UHD3|refseq:NP_084196.4|refseq:XP_006504953.1	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:42tgoThcDyvR8GE7irQd8rHlKL410090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P54071	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-773401|uniprotkb:Q8C2R9|uniprotkb:Q9EQK1|ensembl:ENSMUSP00000103007	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:idhp_mouse(display_long)|uniprotkb:Oxalosuccinate decarboxylase(gene name synonym)|uniprotkb:"NADP(+)-specific ICDH"(gene name synonym)|uniprotkb:IDP(gene name synonym)|uniprotkb:ICD-M(gene name synonym)|uniprotkb:Idh2(gene name)|psi-mi:Idh2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_766599.2|ensembl:ENSMUSG00000030541(gene)|ensembl:ENSMUST00000107384(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004448"(isocitrate dehydrogenase activity)|go:"GO:0004450"("isocitrate dehydrogenase (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0006741"(NADP biosynthetic process)|go:"GO:0051287"(NAD binding)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:1903976"(negative regulation of glial cell migration)|go:"GO:1904465"(negative regulation of matrix metallopeptidase secretion)|interpro:IPR004790(Isocitrate dehydrogenase NADP-dependent, eukaryotic)|interpro:IPR019818|interpro:IPR024084|mint:P54071|rcsb pdb:5H3E|rcsb pdb:5H3F|reactome:R-MMU-2151201|reactome:R-MMU-71403	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:CkBZHIePaNGTtcgyqEf03oczVM010090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8BKN5	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-11075667|uniprotkb:Q8C083|uniprotkb:Q69Z75|uniprotkb:Q8BLJ9|uniprotkb:Q3U8X5|ensembl:ENSMUSP00000032627	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp5_mouse(display_long)|uniprotkb:Tubgcp5(gene name)|psi-mi:Tubgcp5(display_short)|uniprotkb:Kiaa1899(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_666302.2|ensembl:ENSMUSG00000033790(gene)|ensembl:ENSMUST00000032627(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008017"(microtubule binding)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|interpro:IPR042241|mint:Q8BKN5|reactome:R-MMU-380270|reactome:R-MMU-380320	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:1BOIJxOyERW8OOgl7YGHj9W2PMw10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:G5E8P0	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2554025|ensembl:ENSMUSP00000104977|intact:EBI-11600212|uniprotkb:Q6PFC6|uniprotkb:Q6ZPK3|uniprotkb:Q8BWI2	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp6_mouse(display_long)|uniprotkb:Tubgcp6(gene name)|psi-mi:Tubgcp6(display_short)|uniprotkb:Kiaa1669(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001156791.1|ensembl:ENSMUSG00000051786(gene)|ensembl:ENSMUST00000109353(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR042241|mint:G5E8P0|reactome:R-MMU-380270|reactome:R-MMU-380320|interpro:IPR041470	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:o8N6a4n0HmcfpjPF0YcWNZVH39c10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8VCK3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-17170916|ensembl:ENSMUSP00000045901	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tbg2_mouse(display_long)|uniprotkb:Gamma-2-tubulin(gene name synonym)|uniprotkb:Tubg2(gene name)|psi-mi:Tubg2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000045007(gene)|ensembl:ENSMUST00000043654(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|interpro:IPR000217(Tubulin)|interpro:IPR002454(Gamma tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q8VCK3|reactome:R-MMU-380270|reactome:R-MMU-380320|refseq:NP_598789.1	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:ebQHblMVkTKA8wnY1ae2fdPzx8I10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P83887	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2553410|ensembl:ENSMUSP00000048036|uniprotkb:Q9Z310	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tbg1_mouse(display_long)|uniprotkb:Tubg1(gene name)|psi-mi:Tubg1(display_short)|uniprotkb:Tubg(gene name synonym)|uniprotkb:Gamma-1-tubulin(gene name synonym)|uniprotkb:Gamma-tubulin complex component 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000035198(gene)|ensembl:ENSMUST00000043680(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005827"(polar microtubule)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005929"(cilium)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0055037"(recycling endosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000217(Tubulin)|interpro:IPR002454(Gamma tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|go:"GO:0005525"(GTP binding)|interpro:IPR037103|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518|mint:P83887|refseq:NP_598785.1	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:vuOzSmoj6s4iR1pV9zNfwxYjue810090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P58854	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2551135|ensembl:ENSMUSP00000000776|uniprotkb:Q6PDQ9	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp3_mouse(display_long)|uniprotkb:Gcp3(gene name synonym)|uniprotkb:Tubgcp3(gene name)|psi-mi:Tubgcp3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	reactome:R-MMU-380320|ensembl:ENSMUSG00000000759(gene)|ensembl:ENSMUST00000000776(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005827"(polar microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:P58854|reactome:R-MMU-380270|refseq:NP_932148.1	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:qyzJzan6HpBMaAAOyhPM+94ecQA10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q921G8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2552389|ensembl:ENSMUSP00000026547|uniprotkb:G5E859	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp2_mouse(display_long)|uniprotkb:Gcp2(gene name synonym)|uniprotkb:Tubgcp2(gene name)|psi-mi:Tubgcp2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472433|imex:IM-28526-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001272936.1|ensembl:ENSMUSG00000025474(gene)|ensembl:ENSMUST00000026547(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0001764"(neuron migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007420"(brain development)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:Q921G8|reactome:R-MMU-380270|reactome:R-MMU-380320|go:"GO:0000923"(equatorial microtubule organizing center)|refseq:NP_598516.2	-	-	-	figure legend:ST3|comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q20 mice,10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:rWPzsdt3ECnxr+ksi4MaH7okQ+M10090	rigid:a0qxlz+Scl9KkeD32ArKyd3kwCk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P51660	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8328056|intact:MINT-1859569|intact:MINT-2512164|uniprotkb:Q9DBM3|ensembl:ENSMUSP00000025385	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:dhb4_mouse(display_long)|uniprotkb:Hsd17b4(gene name)|psi-mi:Hsd17b4(display_short)|uniprotkb:Edh17b4(gene name synonym)|uniprotkb:Multifunctional protein 2(gene name synonym)|uniprotkb:D-bifunctional protein(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032318.2|ensembl:ENSMUSG00000024507(gene)|ensembl:ENSMUST00000025385(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0004303"(estradiol 17-beta-dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0033989"(3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity)|go:"GO:0036111"(very long-chain fatty-acyl-CoA metabolic process)|go:"GO:0036112"(medium-chain fatty-acyl-CoA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0060009"(Sertoli cell development)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR002539(MaoC-like dehydratase)|interpro:IPR003033(Sterol-binding)|interpro:IPR020904|interpro:IPR029069|interpro:IPR036291|interpro:IPR036527|mint:P51660|reactome:R-MMU-193368|reactome:R-MMU-2046106|reactome:R-MMU-389887|reactome:R-MMU-390247|reactome:R-MMU-9033241	-	-	function:Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids|comment:mint	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:71hLYwG2pK+0vOd5eF+qYIa7J5I10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q921H8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8330006|intact:MINT-1858351|ensembl:ENSMUSP00000042351	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:thika_mouse(display_long)|uniprotkb:Acetyl-CoA C-myristoyltransferase(gene name synonym)|uniprotkb:Acaa1a(gene name)|psi-mi:Acaa1a(display_short)|uniprotkb:Acaa1(gene name synonym)|uniprotkb:Beta-ketothiolase A(gene name synonym)|uniprotkb:Acetyl-CoA acyltransferase A(gene name synonym)|uniprotkb:Peroxisomal 3-oxoacyl-CoA thiolase A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_570934.1|refseq:XP_006511986.1|ensembl:ENSMUSG00000036138(gene)|ensembl:ENSMUST00000039784(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008775"(acetate CoA-transferase activity)|go:"GO:0010124"(phenylacetate catabolic process)|go:"GO:0016401"(palmitoyl-CoA oxidase activity)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:Q921H8|reactome:R-MMU-2046106|reactome:R-MMU-390247|reactome:R-MMU-6798695|reactome:R-MMU-9033241	-	-	comment:mint	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:A7f6/enaS9RJZ+DDXxVXXa/9vTU10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8R4H2	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8046267|intact:MINT-1774761|uniprotkb:E9QPW9|uniprotkb:Q80U18|ensembl:ENSMUSP00000072547	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:arhgc_mouse(display_long)|uniprotkb:Arhgef12(gene name)|psi-mi:Arhgef12(display_short)|uniprotkb:Kiaa0382(gene name synonym)|uniprotkb:Larg(gene name synonym)|uniprotkb:Leukemia-associated RhoGEF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:XP_006510649.1|ensembl:ENSMUSG00000059495(gene)|ensembl:ENSMUST00000072767(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037801|interpro:IPR037884|interpro:IPR041020|mint:Q8R4H2|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148	-	-	comment:mint|function:"May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13"	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:5ZclDYjaUBilqiB548/6M5KlhVg10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9D4F8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-7780439|ensembl:ENSMUSP00000044049|intact:UNK-5542993	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp4_mouse(display_long)|uniprotkb:Tubgcp4(gene name)|psi-mi:Tubgcp4(display_short)|uniprotkb:D2Ertd435e(gene name synonym)|uniprotkb:Gcp4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000027263(gene)|ensembl:ENSMUST00000039541(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005813"(centrosome)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0055037"(recycling endosome)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|interpro:IPR042241|mint:Q9D4F8|reactome:R-MMU-380270|reactome:R-MMU-380320|go:"GO:0005874"(microtubule)|refseq:NP_700436.1	-	-	function:Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome|comment:mint	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:uoyvScV5OQTR+AqUMMIYMhe/a/Q10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P01942	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-494191	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:hba_mouse(display_long)|uniprotkb:Hemoglobin alpha chain(gene name synonym)|uniprotkb:Alpha-globin(gene name synonym)|uniprotkb:Hba(gene name)|psi-mi:Hba(display_short)|uniprotkb:Hba-a1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	dip:DIP-34118N|go:"GO:0048821"(erythrocyte development)|go:"GO:0098869"(cellular oxidant detoxification)|interpro:IPR000971(Globin, subset)|interpro:IPR002338(Haemoglobin, alpha)|interpro:IPR002339(Haemoglobin, pi)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|rcsb pdb:3HRW|reactome:R-MMU-1237044|reactome:R-MMU-1247673|reactome:R-MMU-2168880|reactome:R-MMU-9707564|reactome:R-MMU-9707616|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0009617"(response to bacterium)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|mint:P01942	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:PbMJ6ngi/QKo4CGt7XQMqTFT6RU10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P09411	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1634776|uniprotkb:Q3TPE6|uniprotkb:Q3UKV8|uniprotkb:Q5XJE7|ensembl:ENSMUSP00000080302	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:pgk1_mouse(display_long)|uniprotkb:Pgk1(gene name)|psi-mi:Pgk1(display_short)|uniprotkb:Pgk-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032854.2|dip:DIP-51710N|ensembl:ENSMUSG00000062070(gene)|ensembl:ENSMUST00000081593(transcript)|go:"GO:0004618"(phosphoglycerate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0016310"(phosphorylation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031639"(plasminogen activation)|go:"GO:0043531"(ADP binding)|go:"GO:0045121"(membrane raft)|go:"GO:0047134"("protein-disulfide reductase (NAD(P)) activity")|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001576(Phosphoglycerate kinase)|interpro:IPR015824(Phosphoglycerate kinase, N-terminal)|interpro:IPR015911(Phosphoglycerate kinase, conserved site)|interpro:IPR036043|mint:P09411|rcsb pdb:4O3F|reactome:R-MMU-70171|reactome:R-MMU-70263	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:388hPtU1n0xYbopG53ZWslYTzuk10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P24270	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2924912|uniprotkb:Q3TXQ6|ensembl:ENSMUSP00000028610	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:cata_mouse(display_long)|uniprotkb:Cat(gene name)|psi-mi:Cat(display_short)|uniprotkb:Cas-1(gene name synonym)|uniprotkb:Cas1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0055093"(response to hyperoxia)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0080184"(response to phenylpropanoid)|interpro:IPR002226(Catalase)|interpro:IPR010582(Catalase-related)|interpro:IPR011614(Catalase, N-terminal)|interpro:IPR018028|interpro:IPR020835|interpro:IPR024708|interpro:IPR024711|interpro:IPR040333|mint:P24270|reactome:R-MMU-3299685|reactome:R-MMU-6798695|reactome:R-MMU-9033241|go:"GO:0051781"(positive regulation of cell division)|ensembl:ENSMUSG00000027187(gene)|ensembl:ENSMUST00000028610(transcript)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0004096"(catalase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009642"(response to light intensity)|go:"GO:0009650"(UV protection)|go:"GO:0010193"(response to ozone)|go:"GO:0010288"(response to lead ion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0016209"(antioxidant activity)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019899"(enzyme binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|refseq:NP_033934.2	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Ahsw8/VMIQAUw7mWuBSFRn9g/3M10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P32020	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-309563|uniprotkb:Q9DBM7|uniprotkb:A2APS2|uniprotkb:A2APS3|ensembl:ENSMUSP00000030340	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:scp2_mouse(display_long)|uniprotkb:Scp2(gene name)|psi-mi:Scp2(display_short)|uniprotkb:Scp-2(gene name synonym)|uniprotkb:Propanoyl-CoA C-acyltransferase(gene name synonym)|uniprotkb:Sterol carrier protein X(gene name synonym)|uniprotkb:SCP-chi(gene name synonym)|uniprotkb:Acetyl-CoA C-myristoyltransferase(gene name synonym)|uniprotkb:Non-specific lipid-transfer protein(gene name synonym)|uniprotkb:SCP-2/3-oxoacyl-CoA thiolase(gene name synonym)|uniprotkb:SCP-2/thiolase(gene name synonym)|uniprotkb:Straight-chain acyl-CoA oxidase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035457.1|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006701"(progesterone biosynthetic process)|go:"GO:0007031"(peroxisome organization)|go:"GO:0007568"(aging)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008526"(phosphatidylinositol transfer activity)|go:"GO:0010893"(positive regulation of steroid biosynthetic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032385"(positive regulation of intracellular cholesterol transport)|go:"GO:0032934"(sterol binding)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033814"(propanoyl-CoA C-acyltransferase activity)|go:"GO:0036042"(long-chain fatty acyl-CoA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045940"(positive regulation of steroid metabolic process)|go:"GO:0050632"(propionyl-CoA C2-trimethyltridecanoyltransferase activity)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|go:"GO:0070538"(oleic acid binding)|go:"GO:0071071"(regulation of phospholipid biosynthetic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0120019"(phosphatidylcholine transfer activity)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1901373"(lipid hydroperoxide transport)|go:"GO:1904109"(positive regulation of cholesterol import)|go:"GO:1904121"(phosphatidylethanolamine transfer activity)|interpro:IPR003033(Sterol-binding)|interpro:IPR016039(Thiolase-like)|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|interpro:IPR036527|mint:P32020|go:"GO:0006637"(acyl-CoA metabolic process)|ensembl:ENSMUSG00000028603(gene)|ensembl:ENSMUST00000030340(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:IpeZbl/Hw0r6QueEBBV8WBaMnNM10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9WV30	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472334|ensembl:ENSMUSP00000116094|uniprotkb:E9Q0P3|uniprotkb:E9Q6U2|uniprotkb:G5E8N9|uniprotkb:Q91WY0|uniprotkb:Q9JLA1	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:nfat5_mouse(display_long)|uniprotkb:Nfat5(gene name)|psi-mi:Nfat5(display_short)|uniprotkb:Rel domain-containing transcription factor NFAT5(gene name synonym)|uniprotkb:T-cell transcription factor NFAT5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000003847(gene)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0010628"(positive regulation of gene expression)|ensembl:ENSMUST00000125721(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|interpro:IPR011539(Rel homology)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0005634"(nucleus)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0005654"(nucleoplasm)|interpro:IPR015646(Nuclear factor of activated T-cells 5)|interpro:IPR032397|interpro:IPR037059|mint:Q9WV30|refseq:NP_001273189.1|refseq:NP_061293.2|refseq:NP_598718.2|refseq:XP_006531255.1|refseq:XP_017168393.1	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Yf1n8cmeTkVMCL5aw+LQZwrAIcM10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q5SRY7	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-11073522|uniprotkb:Q923H0|uniprotkb:Q3TLZ8|uniprotkb:Q3TGM9|uniprotkb:Q8K022|uniprotkb:Q8BY90|ensembl:ENSMUSP00000090893	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fbw1b_mouse(display_long)|uniprotkb:Fbxw11(gene name)|psi-mi:Fbxw11(display_short)|uniprotkb:Btrcp2(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:Fbw1b(gene name synonym)|uniprotkb:Fbxw1b(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001258276.1|refseq:NP_001258277.1|refseq:NP_001258278.1|refseq:NP_598776.1|ensembl:ENSMUSG00000020271(gene)|ensembl:ENSMUST00000093205(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048511"(rhythmic process)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q5SRY7|reactome:R-MMU-1169091|reactome:R-MMU-202424|reactome:R-MMU-2565942|reactome:R-MMU-2871837|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5676590|reactome:R-MMU-5684264|reactome:R-MMU-8951664|reactome:R-MMU-983168|dip:DIP-59921N	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:ahDg2ntR1uE9TEaFa8xgmsH3Ijg10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P11276	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-641955|uniprotkb:G5E8B8|uniprotkb:Q61567|uniprotkb:Q61568|uniprotkb:Q61569|uniprotkb:Q64233|uniprotkb:Q80UI4|ensembl:ENSMUSP00000054499	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:finc_mouse(display_long)|uniprotkb:Fn1(gene name)|psi-mi:Fn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_034363.1|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P11276|rcsb pdb:1MFN|rcsb pdb:2MFN|reactome:R-MMU-114608|reactome:R-MMU-1474228|reactome:R-MMU-1474244|reactome:R-MMU-1566977|reactome:R-MMU-202733|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000170|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381426|reactome:R-MMU-5674135|reactome:R-MMU-8874081|reactome:R-MMU-8957275|ensembl:ENSMUSG00000026193(gene)|ensembl:ENSMUST00000055226(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005577"(fibrinogen complex)	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:qndGPG6vmzpIIkDuO1BrVRI1oPg10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P35441	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-6171593	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tsp1_mouse(display_long)|uniprotkb:Thbs1(gene name)|psi-mi:Thbs1(display_short)|uniprotkb:Tsp1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0043236"(laminin binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|reactome:R-MMU-114608|reactome:R-MMU-186797|reactome:R-MMU-216083|reactome:R-MMU-5173214|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016477"(cell migration)|interpro:IPR001881(EGF-like calcium-binding)|mint:P35441|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR017897|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:0j9TPpvxNW9TNMFkFCNo+9wD3fA10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q91VN4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-776230|uniprotkb:Q3UNQ1|uniprotkb:Q9D5I5|uniprotkb:Q9DAM8|ensembl:ENSMUSP00000032172	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mic25_mouse(display_long)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 6(gene name synonym)|uniprotkb:Mic25(gene name synonym)|uniprotkb:Chchd6(gene name)|psi-mi:Chchd6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001161208.1|refseq:NP_079627.3|ensembl:ENSMUSG00000030086(gene)|ensembl:ENSMUST00000032172(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|interpro:IPR042860|mint:Q91VN4	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Op64pUsaaQVJ4d+W9vkGMMkgI8810090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q6P1F6	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-997427|ensembl:ENSMUSP00000086640	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:2aba_mouse(display_long)|uniprotkb:PP2A subunit B isoform alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-alpha(gene name synonym)|uniprotkb:Ppp2r2a(gene name)|psi-mi:Ppp2r2a(display_short)|uniprotkb:PP2A subunit B isoform R2-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001192117.1|refseq:NP_082308.1|ensembl:ENSMUSG00000022052(gene)|ensembl:ENSMUST00000089230(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0043278"(response to morphine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:Q6P1F6|reactome:R-MMU-2995383|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-975957	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:evS6klM2alZXtMthVsshKkrNgiA10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P01027	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-4281083|uniprotkb:Q80XP1|ensembl:ENSMUSP00000024988|uniprotkb:Q61370	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:co3_mouse(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:HSE-MSF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000024164(gene)|ensembl:ENSMUST00000024988(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008289"(lipid binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01027|rcsb pdb:6XZU|reactome:R-MMU-173736|reactome:R-MMU-174577|reactome:R-MMU-198933|reactome:R-MMU-375276|reactome:R-MMU-381426|reactome:R-MMU-418594|reactome:R-MMU-6798695|reactome:R-MMU-8957275|reactome:R-MMU-977606|refseq:NP_033908.2	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:VGFRYhKETrS9O7cyeJZyxBFgBL410090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9CQ25	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2552037|ensembl:ENSMUSP00000023351|ensembl:ENSMUSP00000113832	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mzt2_mouse(display_long)|uniprotkb:Fam128b(gene name synonym)|uniprotkb:Mozart2(gene name synonym)|uniprotkb:Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B(gene name synonym)|uniprotkb:Mzt2(gene name)|psi-mi:Mzt2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|interpro:IPR024332|ensembl:ENSMUSG00000022671(gene)|mint:Q9CQ25|reactome:R-MMU-380270|reactome:R-MMU-380320|ensembl:ENSMUST00000023351(transcript)|ensembl:ENSMUST00000117136(transcript)|refseq:NP_083630.1|refseq:XP_006522651.1	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:heL4NryOHurQ03jZtyHwM/D5Xe810090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9CQR4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-299825|ensembl:ENSMUSP00000006900	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:aco13_mouse(display_long)|uniprotkb:Acot13(gene name)|psi-mi:Acot13(display_short)|uniprotkb:Hotdog-fold thioesterase superfamily member 2(gene name synonym)|uniprotkb:Palmitoyl-CoA hydrolase(gene name synonym)|uniprotkb:Them2(gene name synonym)|uniprotkb:Thioesterase superfamily member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000006717(gene)|ensembl:ENSMUST00000006900(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR003736(Phenylacetic acid degradation-related protein)|interpro:IPR006683(Thioesterase superfamily)|interpro:IPR029069|interpro:IPR039298|mint:Q9CQR4|rcsb pdb:2CY9|reactome:R-MMU-77289|refseq:NP_080066.1	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:jMok2ZPtX2ETleMlnA+90d/FVxs10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8BUR9	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2553237|ensembl:ENSMUSP00000037557	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mzt1_mouse(display_long)|uniprotkb:Mzt1(gene name)|psi-mi:Mzt1(display_short)|uniprotkb:Mozart1(gene name synonym)|uniprotkb:Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUST00000042662(transcript)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0033566"(gamma-tubulin complex localization)|go:"GO:0051415"(microtubule nucleation by interphase microtubule organizing center)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR022214|mint:Q8BUR9|reactome:R-MMU-380270|reactome:R-MMU-380320|ensembl:ENSMUSG00000033186(gene)|refseq:NP_780454.1	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:a686Bpxk37Kl0gKKTz14f6sq6s410090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P33215	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2366213|uniprotkb:Q6NXV3|uniprotkb:Q8BN12|uniprotkb:Q8BN86|uniprotkb:Q8BQL9|uniprotkb:Q9CWK2|ensembl:ENSMUSP00000020163	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:nedd1_mouse(display_long)|uniprotkb:Nedd1(gene name)|psi-mi:Nedd1(display_short)|uniprotkb:Nedd-1(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032708.2|ensembl:ENSMUSG00000019988(gene)|ensembl:ENSMUST00000020163(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000922"(spindle pole)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0031109"(microtubule polymerization or depolymerization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045177"(apical part of cell)|go:"GO:0051301"(cell division)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P33215|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:xBFWC64fRlKEVonqdYWgcVEPK0010090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P07724	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1183810|uniprotkb:Q3TV03|uniprotkb:Q61802|uniprotkb:Q8C7C7|uniprotkb:Q8C7H3|uniprotkb:Q8CG74|ensembl:ENSMUSP00000031314	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:albu_mouse(display_long)|uniprotkb:Alb(gene name)|psi-mi:Alb(display_short)|uniprotkb:Alb1(gene name synonym)|uniprotkb:Alb-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_033784.2|ensembl:ENSMUSG00000029368(gene)|ensembl:ENSMUST00000031314(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0019825"(oxygen binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0046010"(positive regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0051087"(chaperone binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072341"(modified amino acid binding)|go:"GO:0140272"(exogenous protein binding)|go:"GO:1903981"(enterobactin binding)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR020857|interpro:IPR020858|interpro:IPR021177|mint:P07724|reactome:R-MMU-114608|reactome:R-MMU-159418|reactome:R-MMU-189451|reactome:R-MMU-189483|reactome:R-MMU-2168880|reactome:R-MMU-381426|reactome:R-MMU-879518|reactome:R-MMU-8957275|reactome:R-MMU-8964058|reactome:R-MMU-9707564	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:R7zO/mB332rAl8J+WrXfsHzjSYs10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9QXL8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472305	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:ndk7_mouse(display_long)|uniprotkb:Nme7(gene name)|psi-mi:Nme7(display_short)|uniprotkb:nm23-M7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	reactome:R-MMU-380320|go:"GO:0003351"(epithelial cilium movement involved in extracellular fluid movement)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005813"(centrosome)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0060830"(ciliary receptor clustering involved in smoothened signaling pathway)|go:"GO:0060972"(left/right pattern formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|reactome:R-MMU-380270|mint:Q9QXL8|interpro:IPR034907|interpro:IPR036850|interpro:IPR011410(Nucleoside diphosphate kinase, NDK7)|interpro:IPR035525|interpro:IPR037993|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR006602(Region of unknown function DM10)	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:zkOjHmuz7jAgTi/5/MQYROLtVKg10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q3UHD3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472278|ensembl:ENSMUSP00000082694|uniprotkb:B9EKJ2|uniprotkb:Q7TPP7|uniprotkb:Q8CHD2|uniprotkb:Q9CY74	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mtus2_mouse(display_long)|uniprotkb:Mtus2(gene name)|psi-mi:Mtus2(display_short)|uniprotkb:Cazip(gene name synonym)|uniprotkb:Kiaa0774(gene name synonym)|uniprotkb:Tip150(gene name synonym)|uniprotkb:Cardiac zipper protein(gene name synonym)|uniprotkb:Microtubule plus-end tracking protein TIP150(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000029651(gene)|ensembl:ENSMUST00000085558(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR033339|mint:Q3UHD3|refseq:NP_084196.4|refseq:XP_006504953.1	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:42tgoThcDyvR8GE7irQd8rHlKL410090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P54071	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-773401|uniprotkb:Q8C2R9|uniprotkb:Q9EQK1|ensembl:ENSMUSP00000103007	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:idhp_mouse(display_long)|uniprotkb:Oxalosuccinate decarboxylase(gene name synonym)|uniprotkb:"NADP(+)-specific ICDH"(gene name synonym)|uniprotkb:IDP(gene name synonym)|uniprotkb:ICD-M(gene name synonym)|uniprotkb:Idh2(gene name)|psi-mi:Idh2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_766599.2|ensembl:ENSMUSG00000030541(gene)|ensembl:ENSMUST00000107384(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004448"(isocitrate dehydrogenase activity)|go:"GO:0004450"("isocitrate dehydrogenase (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0006741"(NADP biosynthetic process)|go:"GO:0051287"(NAD binding)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:1903976"(negative regulation of glial cell migration)|go:"GO:1904465"(negative regulation of matrix metallopeptidase secretion)|interpro:IPR004790(Isocitrate dehydrogenase NADP-dependent, eukaryotic)|interpro:IPR019818|interpro:IPR024084|mint:P54071|rcsb pdb:5H3E|rcsb pdb:5H3F|reactome:R-MMU-2151201|reactome:R-MMU-71403	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:CkBZHIePaNGTtcgyqEf03oczVM010090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8BKN5	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-11075667|uniprotkb:Q8C083|uniprotkb:Q69Z75|uniprotkb:Q8BLJ9|uniprotkb:Q3U8X5|ensembl:ENSMUSP00000032627	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp5_mouse(display_long)|uniprotkb:Tubgcp5(gene name)|psi-mi:Tubgcp5(display_short)|uniprotkb:Kiaa1899(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_666302.2|ensembl:ENSMUSG00000033790(gene)|ensembl:ENSMUST00000032627(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008017"(microtubule binding)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|interpro:IPR042241|mint:Q8BKN5|reactome:R-MMU-380270|reactome:R-MMU-380320	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:1BOIJxOyERW8OOgl7YGHj9W2PMw10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:G5E8P0	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2554025|ensembl:ENSMUSP00000104977|intact:EBI-11600212|uniprotkb:Q6PFC6|uniprotkb:Q6ZPK3|uniprotkb:Q8BWI2	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp6_mouse(display_long)|uniprotkb:Tubgcp6(gene name)|psi-mi:Tubgcp6(display_short)|uniprotkb:Kiaa1669(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001156791.1|ensembl:ENSMUSG00000051786(gene)|ensembl:ENSMUST00000109353(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR042241|mint:G5E8P0|reactome:R-MMU-380270|reactome:R-MMU-380320|interpro:IPR041470	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:o8N6a4n0HmcfpjPF0YcWNZVH39c10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8VCK3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-17170916|ensembl:ENSMUSP00000045901	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tbg2_mouse(display_long)|uniprotkb:Gamma-2-tubulin(gene name synonym)|uniprotkb:Tubg2(gene name)|psi-mi:Tubg2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000045007(gene)|ensembl:ENSMUST00000043654(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|interpro:IPR000217(Tubulin)|interpro:IPR002454(Gamma tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q8VCK3|reactome:R-MMU-380270|reactome:R-MMU-380320|refseq:NP_598789.1	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:ebQHblMVkTKA8wnY1ae2fdPzx8I10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P83887	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2553410|ensembl:ENSMUSP00000048036|uniprotkb:Q9Z310	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tbg1_mouse(display_long)|uniprotkb:Tubg1(gene name)|psi-mi:Tubg1(display_short)|uniprotkb:Tubg(gene name synonym)|uniprotkb:Gamma-1-tubulin(gene name synonym)|uniprotkb:Gamma-tubulin complex component 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000035198(gene)|ensembl:ENSMUST00000043680(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005827"(polar microtubule)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005929"(cilium)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0055037"(recycling endosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000217(Tubulin)|interpro:IPR002454(Gamma tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|go:"GO:0005525"(GTP binding)|interpro:IPR037103|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518|mint:P83887|refseq:NP_598785.1	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:vuOzSmoj6s4iR1pV9zNfwxYjue810090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P58854	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2551135|ensembl:ENSMUSP00000000776|uniprotkb:Q6PDQ9	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp3_mouse(display_long)|uniprotkb:Gcp3(gene name synonym)|uniprotkb:Tubgcp3(gene name)|psi-mi:Tubgcp3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	reactome:R-MMU-380320|ensembl:ENSMUSG00000000759(gene)|ensembl:ENSMUST00000000776(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005827"(polar microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:P58854|reactome:R-MMU-380270|refseq:NP_932148.1	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:qyzJzan6HpBMaAAOyhPM+94ecQA10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q921G8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2552389|ensembl:ENSMUSP00000026547|uniprotkb:G5E859	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp2_mouse(display_long)|uniprotkb:Gcp2(gene name synonym)|uniprotkb:Tubgcp2(gene name)|psi-mi:Tubgcp2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472475|imex:IM-28526-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001272936.1|ensembl:ENSMUSG00000025474(gene)|ensembl:ENSMUST00000026547(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0001764"(neuron migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007420"(brain development)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:Q921G8|reactome:R-MMU-380270|reactome:R-MMU-380320|go:"GO:0000923"(equatorial microtubule organizing center)|refseq:NP_598516.2	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:rWPzsdt3ECnxr+ksi4MaH7okQ+M10090	rigid:j/fm/w68Bki9m9EIXQy0DpSZgo0	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P51660	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8328056|intact:MINT-1859569|intact:MINT-2512164|uniprotkb:Q9DBM3|ensembl:ENSMUSP00000025385	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:dhb4_mouse(display_long)|uniprotkb:Hsd17b4(gene name)|psi-mi:Hsd17b4(display_short)|uniprotkb:Edh17b4(gene name synonym)|uniprotkb:Multifunctional protein 2(gene name synonym)|uniprotkb:D-bifunctional protein(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032318.2|ensembl:ENSMUSG00000024507(gene)|ensembl:ENSMUST00000025385(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0004303"(estradiol 17-beta-dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0033989"(3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity)|go:"GO:0036111"(very long-chain fatty-acyl-CoA metabolic process)|go:"GO:0036112"(medium-chain fatty-acyl-CoA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0060009"(Sertoli cell development)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR002539(MaoC-like dehydratase)|interpro:IPR003033(Sterol-binding)|interpro:IPR020904|interpro:IPR029069|interpro:IPR036291|interpro:IPR036527|mint:P51660|reactome:R-MMU-193368|reactome:R-MMU-2046106|reactome:R-MMU-389887|reactome:R-MMU-390247|reactome:R-MMU-9033241	-	-	function:Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids|comment:mint	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:71hLYwG2pK+0vOd5eF+qYIa7J5I10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q921H8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8330006|intact:MINT-1858351|ensembl:ENSMUSP00000042351	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:thika_mouse(display_long)|uniprotkb:Acetyl-CoA C-myristoyltransferase(gene name synonym)|uniprotkb:Acaa1a(gene name)|psi-mi:Acaa1a(display_short)|uniprotkb:Acaa1(gene name synonym)|uniprotkb:Beta-ketothiolase A(gene name synonym)|uniprotkb:Acetyl-CoA acyltransferase A(gene name synonym)|uniprotkb:Peroxisomal 3-oxoacyl-CoA thiolase A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_570934.1|refseq:XP_006511986.1|ensembl:ENSMUSG00000036138(gene)|ensembl:ENSMUST00000039784(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008775"(acetate CoA-transferase activity)|go:"GO:0010124"(phenylacetate catabolic process)|go:"GO:0016401"(palmitoyl-CoA oxidase activity)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:Q921H8|reactome:R-MMU-2046106|reactome:R-MMU-390247|reactome:R-MMU-6798695|reactome:R-MMU-9033241	-	-	comment:mint	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:A7f6/enaS9RJZ+DDXxVXXa/9vTU10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P28665	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8320382|intact:MINT-4102594|uniprotkb:Q3UNE7|intact:MINT-1862833|uniprotkb:Q80XE6|ensembl:ENSMUSP00000032228	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mug1_mouse(display_long)|uniprotkb:Mug1(gene name)|psi-mi:Mug1(display_short)|uniprotkb:Mug-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032671.2|ensembl:ENSMUSG00000059908(gene)|ensembl:ENSMUST00000032228(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007566"(embryo implantation)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR010916(TonB box, conserved site)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR019742|interpro:IPR036595|interpro:IPR040839|interpro:IPR041555|interpro:IPR041813|mint:P28665	-	-	function:A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective|comment:mint	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:zlCQxuDrGyWSoKUL6Iuuz5ZMi3w10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8R4H2	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8046267|intact:MINT-1774761|uniprotkb:E9QPW9|uniprotkb:Q80U18|ensembl:ENSMUSP00000072547	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:arhgc_mouse(display_long)|uniprotkb:Arhgef12(gene name)|psi-mi:Arhgef12(display_short)|uniprotkb:Kiaa0382(gene name synonym)|uniprotkb:Larg(gene name synonym)|uniprotkb:Leukemia-associated RhoGEF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:XP_006510649.1|ensembl:ENSMUSG00000059495(gene)|ensembl:ENSMUST00000072767(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037801|interpro:IPR037884|interpro:IPR041020|mint:Q8R4H2|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148	-	-	comment:mint|function:"May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13"	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:5ZclDYjaUBilqiB548/6M5KlhVg10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9D4F8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-7780439|ensembl:ENSMUSP00000044049|intact:UNK-5542993	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp4_mouse(display_long)|uniprotkb:Tubgcp4(gene name)|psi-mi:Tubgcp4(display_short)|uniprotkb:D2Ertd435e(gene name synonym)|uniprotkb:Gcp4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000027263(gene)|ensembl:ENSMUST00000039541(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005813"(centrosome)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0055037"(recycling endosome)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|interpro:IPR042241|mint:Q9D4F8|reactome:R-MMU-380270|reactome:R-MMU-380320|go:"GO:0005874"(microtubule)|refseq:NP_700436.1	-	-	function:Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome|comment:mint	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:uoyvScV5OQTR+AqUMMIYMhe/a/Q10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P14152	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-494462|uniprotkb:Q3TP22|uniprotkb:Q80Y13|uniprotkb:Q9DB45|ensembl:ENSMUSP00000099938|ensembl:ENSMUSP00000159017	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mdhc_mouse(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:Mdh1(gene name)|psi-mi:Mdh1(display_short)|uniprotkb:Mor2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032644.3|refseq:NP_001303604.1|ensembl:ENSMUSG00000020321(gene)|ensembl:ENSMUST00000102874(transcript)|ensembl:ENSMUST00000239073(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0016615"(malate dehydrogenase activity)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0051287"(NAD binding)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|go:"GO:0006108"(malate metabolic process)|interpro:IPR022383|interpro:IPR036291|mint:P14152|reactome:R-MMU-70263	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Yq74ALpVIoaMM9Y2LUS4Sdmfztg10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P09411	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1634776|uniprotkb:Q3TPE6|uniprotkb:Q3UKV8|uniprotkb:Q5XJE7|ensembl:ENSMUSP00000080302	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:pgk1_mouse(display_long)|uniprotkb:Pgk1(gene name)|psi-mi:Pgk1(display_short)|uniprotkb:Pgk-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032854.2|dip:DIP-51710N|ensembl:ENSMUSG00000062070(gene)|ensembl:ENSMUST00000081593(transcript)|go:"GO:0004618"(phosphoglycerate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0016310"(phosphorylation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031639"(plasminogen activation)|go:"GO:0043531"(ADP binding)|go:"GO:0045121"(membrane raft)|go:"GO:0047134"("protein-disulfide reductase (NAD(P)) activity")|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001576(Phosphoglycerate kinase)|interpro:IPR015824(Phosphoglycerate kinase, N-terminal)|interpro:IPR015911(Phosphoglycerate kinase, conserved site)|interpro:IPR036043|mint:P09411|rcsb pdb:4O3F|reactome:R-MMU-70171|reactome:R-MMU-70263	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:388hPtU1n0xYbopG53ZWslYTzuk10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q3UHB8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-16731180|ensembl:ENSMUSP00000072982|uniprotkb:Q6NXJ5	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:cc177_mouse(display_long)|uniprotkb:Ccdc177(gene name)|psi-mi:Ccdc177(display_short)|uniprotkb:Gm1568(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000062961(gene)|ensembl:ENSMUST00000073251(transcript)|interpro:IPR029090|mint:Q3UHB8|refseq:NP_001008423.2	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:objGQkpHL5Pr4FZHhKDHYGjAVUU10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P62962	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-647096|uniprotkb:P10924|ensembl:ENSMUSP00000018437	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:prof1_mouse(display_long)|uniprotkb:Profilin I(gene name synonym)|uniprotkb:Pfn1(gene name)|psi-mi:Pfn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035202.1|dip:DIP-38075N|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050821"(protein stabilization)|go:"GO:0051054"(positive regulation of DNA metabolic process)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060074"(synapse maturation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR005454(Profilin, Mammalian)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR029892|interpro:IPR036140|mint:P62962|reactome:R-MMU-376176|reactome:R-MMU-4086400|reactome:R-MMU-5663220|ensembl:ENSMUSG00000018293(gene)|ensembl:ENSMUST00000018437(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:nzOTw5XdywGrh+fA9AInGIexyGk10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:E9Q8I9	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-16732044|ensembl:ENSMUSP00000084454|uniprotkb:Q4VA57|uniprotkb:Q5DTL4|uniprotkb:Q8BIW6|uniprotkb:Q8BUA0|uniprotkb:Q8CG91	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fry_mouse(display_long)|uniprotkb:Fry(gene name)|psi-mi:Fry(display_short)|uniprotkb:Kiaa4143(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000056602(gene)|ensembl:ENSMUST00000087204(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005938"(cell cortex)|go:"GO:0030427"(site of polarized growth)|go:"GO:0031175"(neuron projection development)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025481|interpro:IPR025614|interpro:IPR029473|interpro:IPR039867|mint:E9Q8I9|refseq:NP_766475.2|refseq:XP_006504993.1	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:fvduzhqkwcM9qmnWvPWAA1W8HqI10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9WV30	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472334|ensembl:ENSMUSP00000116094|uniprotkb:E9Q0P3|uniprotkb:E9Q6U2|uniprotkb:G5E8N9|uniprotkb:Q91WY0|uniprotkb:Q9JLA1	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:nfat5_mouse(display_long)|uniprotkb:Nfat5(gene name)|psi-mi:Nfat5(display_short)|uniprotkb:Rel domain-containing transcription factor NFAT5(gene name synonym)|uniprotkb:T-cell transcription factor NFAT5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000003847(gene)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0010628"(positive regulation of gene expression)|ensembl:ENSMUST00000125721(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|interpro:IPR011539(Rel homology)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0005634"(nucleus)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0005654"(nucleoplasm)|interpro:IPR015646(Nuclear factor of activated T-cells 5)|interpro:IPR032397|interpro:IPR037059|mint:Q9WV30|refseq:NP_001273189.1|refseq:NP_061293.2|refseq:NP_598718.2|refseq:XP_006531255.1|refseq:XP_017168393.1	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Yf1n8cmeTkVMCL5aw+LQZwrAIcM10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q91VN4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-776230|uniprotkb:Q3UNQ1|uniprotkb:Q9D5I5|uniprotkb:Q9DAM8|ensembl:ENSMUSP00000032172	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mic25_mouse(display_long)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 6(gene name synonym)|uniprotkb:Mic25(gene name synonym)|uniprotkb:Chchd6(gene name)|psi-mi:Chchd6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001161208.1|refseq:NP_079627.3|ensembl:ENSMUSG00000030086(gene)|ensembl:ENSMUST00000032172(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|interpro:IPR042860|mint:Q91VN4	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Op64pUsaaQVJ4d+W9vkGMMkgI8810090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P35441	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-6171593	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tsp1_mouse(display_long)|uniprotkb:Thbs1(gene name)|psi-mi:Thbs1(display_short)|uniprotkb:Tsp1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0043236"(laminin binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|reactome:R-MMU-114608|reactome:R-MMU-186797|reactome:R-MMU-216083|reactome:R-MMU-5173214|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016477"(cell migration)|interpro:IPR001881(EGF-like calcium-binding)|mint:P35441|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR017897|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:0j9TPpvxNW9TNMFkFCNo+9wD3fA10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P01027	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-4281083|uniprotkb:Q80XP1|ensembl:ENSMUSP00000024988|uniprotkb:Q61370	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:co3_mouse(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:HSE-MSF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000024164(gene)|ensembl:ENSMUST00000024988(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008289"(lipid binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01027|rcsb pdb:6XZU|reactome:R-MMU-173736|reactome:R-MMU-174577|reactome:R-MMU-198933|reactome:R-MMU-375276|reactome:R-MMU-381426|reactome:R-MMU-418594|reactome:R-MMU-6798695|reactome:R-MMU-8957275|reactome:R-MMU-977606|refseq:NP_033908.2	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:VGFRYhKETrS9O7cyeJZyxBFgBL410090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9ES28	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-642580|uniprotkb:O08757|uniprotkb:Q3UTS5|uniprotkb:Q6XPA5|uniprotkb:Q6ZQI5|uniprotkb:Q8C750|uniprotkb:Q91ZZ6|uniprotkb:Q9ES27	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:arhg7_mouse(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:p85SPR(gene name synonym)|uniprotkb:Arhgef7(gene name)|psi-mi:Arhgef7(display_short)|uniprotkb:Pak3bp(gene name synonym)|uniprotkb:Kiaa0142(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001106989.1|refseq:NP_001106990.1|refseq:NP_059098.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|refseq:XP_006508906.2|refseq:XP_006508907.2|interpro:IPR032409|refseq:XP_006508904.2|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013424|go:"GO:0000322"(storage vacuole)|go:"GO:0001726"(ruffle)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030426"(growth cone)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099140"(presynaptic actin cytoskeleton organization)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|rcsb pdb:2ESW|rcsb pdb:6JMT|reactome:R-MMU-182971|reactome:R-MMU-193648|reactome:R-MMU-3928664|mint:Q9ES28|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:+Bie+UoaAI9/ldibUxAjNYc3sYs10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P33215	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2366213|uniprotkb:Q6NXV3|uniprotkb:Q8BN12|uniprotkb:Q8BN86|uniprotkb:Q8BQL9|uniprotkb:Q9CWK2|ensembl:ENSMUSP00000020163	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:nedd1_mouse(display_long)|uniprotkb:Nedd1(gene name)|psi-mi:Nedd1(display_short)|uniprotkb:Nedd-1(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032708.2|ensembl:ENSMUSG00000019988(gene)|ensembl:ENSMUST00000020163(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000922"(spindle pole)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0031109"(microtubule polymerization or depolymerization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045177"(apical part of cell)|go:"GO:0051301"(cell division)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P33215|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:xBFWC64fRlKEVonqdYWgcVEPK0010090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9QXL8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472305	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:ndk7_mouse(display_long)|uniprotkb:Nme7(gene name)|psi-mi:Nme7(display_short)|uniprotkb:nm23-M7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	reactome:R-MMU-380320|go:"GO:0003351"(epithelial cilium movement involved in extracellular fluid movement)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005813"(centrosome)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0060830"(ciliary receptor clustering involved in smoothened signaling pathway)|go:"GO:0060972"(left/right pattern formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|reactome:R-MMU-380270|mint:Q9QXL8|interpro:IPR034907|interpro:IPR036850|interpro:IPR011410(Nucleoside diphosphate kinase, NDK7)|interpro:IPR035525|interpro:IPR037993|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR006602(Region of unknown function DM10)	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:zkOjHmuz7jAgTi/5/MQYROLtVKg10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q76MZ3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-400413|ensembl:ENSMUSP00000007708	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:2aaa_mouse(display_long)|uniprotkb:Ppp2r1a(gene name)|psi-mi:Ppp2r1a(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_058587.1|go:"GO:0051306"(mitotic sister chromatid separation)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903538"(regulation of meiotic cell cycle process involved in oocyte maturation)|go:"GO:1990405"(protein antigen binding)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:Q76MZ3|rcsb pdb:2IAE|rcsb pdb:2PF4|rcsb pdb:3FGA|rcsb pdb:6EF4|reactome:R-MMU-113501|reactome:R-MMU-1295596|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-2995383|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-4641262|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6804757|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-8854518|reactome:R-MMU-9648025|reactome:R-MMU-975957|ensembl:ENSMUSG00000007564(gene)|ensembl:ENSMUST00000007708(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030425"(dendrite)|go:"GO:0045202"(synapse)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051232"(meiotic spindle elongation)|dip:DIP-29429N	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:0tnO11U1SNOOT46j23f7dim8O8k10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9CQ25	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2552037|ensembl:ENSMUSP00000023351|ensembl:ENSMUSP00000113832	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mzt2_mouse(display_long)|uniprotkb:Fam128b(gene name synonym)|uniprotkb:Mozart2(gene name synonym)|uniprotkb:Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B(gene name synonym)|uniprotkb:Mzt2(gene name)|psi-mi:Mzt2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|interpro:IPR024332|ensembl:ENSMUSG00000022671(gene)|mint:Q9CQ25|reactome:R-MMU-380270|reactome:R-MMU-380320|ensembl:ENSMUST00000023351(transcript)|ensembl:ENSMUST00000117136(transcript)|refseq:NP_083630.1|refseq:XP_006522651.1	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:heL4NryOHurQ03jZtyHwM/D5Xe810090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9CQR4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-299825|ensembl:ENSMUSP00000006900	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:aco13_mouse(display_long)|uniprotkb:Acot13(gene name)|psi-mi:Acot13(display_short)|uniprotkb:Hotdog-fold thioesterase superfamily member 2(gene name synonym)|uniprotkb:Palmitoyl-CoA hydrolase(gene name synonym)|uniprotkb:Them2(gene name synonym)|uniprotkb:Thioesterase superfamily member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000006717(gene)|ensembl:ENSMUST00000006900(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR003736(Phenylacetic acid degradation-related protein)|interpro:IPR006683(Thioesterase superfamily)|interpro:IPR029069|interpro:IPR039298|mint:Q9CQR4|rcsb pdb:2CY9|reactome:R-MMU-77289|refseq:NP_080066.1	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:jMok2ZPtX2ETleMlnA+90d/FVxs10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q6P1F6	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-997427|ensembl:ENSMUSP00000086640	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:2aba_mouse(display_long)|uniprotkb:PP2A subunit B isoform alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-alpha(gene name synonym)|uniprotkb:Ppp2r2a(gene name)|psi-mi:Ppp2r2a(display_short)|uniprotkb:PP2A subunit B isoform R2-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001192117.1|refseq:NP_082308.1|ensembl:ENSMUSG00000022052(gene)|ensembl:ENSMUST00000089230(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0043278"(response to morphine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:Q6P1F6|reactome:R-MMU-2995383|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-975957	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:evS6klM2alZXtMthVsshKkrNgiA10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8BUR9	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2553237|ensembl:ENSMUSP00000037557	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mzt1_mouse(display_long)|uniprotkb:Mzt1(gene name)|psi-mi:Mzt1(display_short)|uniprotkb:Mozart1(gene name synonym)|uniprotkb:Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUST00000042662(transcript)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0033566"(gamma-tubulin complex localization)|go:"GO:0051415"(microtubule nucleation by interphase microtubule organizing center)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR022214|mint:Q8BUR9|reactome:R-MMU-380270|reactome:R-MMU-380320|ensembl:ENSMUSG00000033186(gene)|refseq:NP_780454.1	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:a686Bpxk37Kl0gKKTz14f6sq6s410090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P11276	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-641955|uniprotkb:G5E8B8|uniprotkb:Q61567|uniprotkb:Q61568|uniprotkb:Q61569|uniprotkb:Q64233|uniprotkb:Q80UI4|ensembl:ENSMUSP00000054499	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:finc_mouse(display_long)|uniprotkb:Fn1(gene name)|psi-mi:Fn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_034363.1|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P11276|rcsb pdb:1MFN|rcsb pdb:2MFN|reactome:R-MMU-114608|reactome:R-MMU-1474228|reactome:R-MMU-1474244|reactome:R-MMU-1566977|reactome:R-MMU-202733|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000170|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381426|reactome:R-MMU-5674135|reactome:R-MMU-8874081|reactome:R-MMU-8957275|ensembl:ENSMUSG00000026193(gene)|ensembl:ENSMUST00000055226(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005577"(fibrinogen complex)	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:qndGPG6vmzpIIkDuO1BrVRI1oPg10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q3UHD3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472278|ensembl:ENSMUSP00000082694|uniprotkb:B9EKJ2|uniprotkb:Q7TPP7|uniprotkb:Q8CHD2|uniprotkb:Q9CY74	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mtus2_mouse(display_long)|uniprotkb:Mtus2(gene name)|psi-mi:Mtus2(display_short)|uniprotkb:Cazip(gene name synonym)|uniprotkb:Kiaa0774(gene name synonym)|uniprotkb:Tip150(gene name synonym)|uniprotkb:Cardiac zipper protein(gene name synonym)|uniprotkb:Microtubule plus-end tracking protein TIP150(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000029651(gene)|ensembl:ENSMUST00000085558(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR033339|mint:Q3UHD3|refseq:NP_084196.4|refseq:XP_006504953.1	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:42tgoThcDyvR8GE7irQd8rHlKL410090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8C0D4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472248|ensembl:ENSMUSP00000138585|uniprotkb:Q8BVP8	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:rhg12_mouse(display_long)|uniprotkb:Arhgap12(gene name)|psi-mi:Arhgap12(display_short)|uniprotkb:Rho-type GTPase-activating protein 12(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000041225(gene)|ensembl:ENSMUST00000182559(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035491|interpro:IPR036020|interpro:IPR036028|mint:Q8C0D4|rcsb pdb:6GVC|reactome:R-MMU-9013149|reactome:R-MMU-9013405|reactome:R-MMU-9013424|reactome:R-MMU-9035034|refseq:NP_001034781.1|refseq:NP_083553.2	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:daP4oZJo5g2WAFHv8quvfttZ0H810090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P54071	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-773401|uniprotkb:Q8C2R9|uniprotkb:Q9EQK1|ensembl:ENSMUSP00000103007	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:idhp_mouse(display_long)|uniprotkb:Oxalosuccinate decarboxylase(gene name synonym)|uniprotkb:"NADP(+)-specific ICDH"(gene name synonym)|uniprotkb:IDP(gene name synonym)|uniprotkb:ICD-M(gene name synonym)|uniprotkb:Idh2(gene name)|psi-mi:Idh2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_766599.2|ensembl:ENSMUSG00000030541(gene)|ensembl:ENSMUST00000107384(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004448"(isocitrate dehydrogenase activity)|go:"GO:0004450"("isocitrate dehydrogenase (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0006741"(NADP biosynthetic process)|go:"GO:0051287"(NAD binding)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:1903976"(negative regulation of glial cell migration)|go:"GO:1904465"(negative regulation of matrix metallopeptidase secretion)|interpro:IPR004790(Isocitrate dehydrogenase NADP-dependent, eukaryotic)|interpro:IPR019818|interpro:IPR024084|mint:P54071|rcsb pdb:5H3E|rcsb pdb:5H3F|reactome:R-MMU-2151201|reactome:R-MMU-71403	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:CkBZHIePaNGTtcgyqEf03oczVM010090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8BKN5	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-11075667|uniprotkb:Q8C083|uniprotkb:Q69Z75|uniprotkb:Q8BLJ9|uniprotkb:Q3U8X5|ensembl:ENSMUSP00000032627	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp5_mouse(display_long)|uniprotkb:Tubgcp5(gene name)|psi-mi:Tubgcp5(display_short)|uniprotkb:Kiaa1899(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_666302.2|ensembl:ENSMUSG00000033790(gene)|ensembl:ENSMUST00000032627(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008017"(microtubule binding)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|interpro:IPR042241|mint:Q8BKN5|reactome:R-MMU-380270|reactome:R-MMU-380320	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:1BOIJxOyERW8OOgl7YGHj9W2PMw10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:G5E8P0	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2554025|ensembl:ENSMUSP00000104977|intact:EBI-11600212|uniprotkb:Q6PFC6|uniprotkb:Q6ZPK3|uniprotkb:Q8BWI2	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp6_mouse(display_long)|uniprotkb:Tubgcp6(gene name)|psi-mi:Tubgcp6(display_short)|uniprotkb:Kiaa1669(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001156791.1|ensembl:ENSMUSG00000051786(gene)|ensembl:ENSMUST00000109353(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR042241|mint:G5E8P0|reactome:R-MMU-380270|reactome:R-MMU-380320|interpro:IPR041470	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:o8N6a4n0HmcfpjPF0YcWNZVH39c10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8VCK3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-17170916|ensembl:ENSMUSP00000045901	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tbg2_mouse(display_long)|uniprotkb:Gamma-2-tubulin(gene name synonym)|uniprotkb:Tubg2(gene name)|psi-mi:Tubg2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000045007(gene)|ensembl:ENSMUST00000043654(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|interpro:IPR000217(Tubulin)|interpro:IPR002454(Gamma tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q8VCK3|reactome:R-MMU-380270|reactome:R-MMU-380320|refseq:NP_598789.1	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:ebQHblMVkTKA8wnY1ae2fdPzx8I10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P83887	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2553410|ensembl:ENSMUSP00000048036|uniprotkb:Q9Z310	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tbg1_mouse(display_long)|uniprotkb:Tubg1(gene name)|psi-mi:Tubg1(display_short)|uniprotkb:Tubg(gene name synonym)|uniprotkb:Gamma-1-tubulin(gene name synonym)|uniprotkb:Gamma-tubulin complex component 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000035198(gene)|ensembl:ENSMUST00000043680(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005827"(polar microtubule)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005929"(cilium)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0055037"(recycling endosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000217(Tubulin)|interpro:IPR002454(Gamma tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|go:"GO:0005525"(GTP binding)|interpro:IPR037103|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518|mint:P83887|refseq:NP_598785.1	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:vuOzSmoj6s4iR1pV9zNfwxYjue810090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P58854	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2551135|ensembl:ENSMUSP00000000776|uniprotkb:Q6PDQ9	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp3_mouse(display_long)|uniprotkb:Gcp3(gene name synonym)|uniprotkb:Tubgcp3(gene name)|psi-mi:Tubgcp3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	reactome:R-MMU-380320|ensembl:ENSMUSG00000000759(gene)|ensembl:ENSMUST00000000776(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005827"(polar microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:P58854|reactome:R-MMU-380270|refseq:NP_932148.1	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:qyzJzan6HpBMaAAOyhPM+94ecQA10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q921G8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2552389|ensembl:ENSMUSP00000026547|uniprotkb:G5E859	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp2_mouse(display_long)|uniprotkb:Gcp2(gene name synonym)|uniprotkb:Tubgcp2(gene name)|psi-mi:Tubgcp2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472509|imex:IM-28526-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001272936.1|ensembl:ENSMUSG00000025474(gene)|ensembl:ENSMUST00000026547(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0001764"(neuron migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007420"(brain development)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:Q921G8|reactome:R-MMU-380270|reactome:R-MMU-380320|go:"GO:0000923"(equatorial microtubule organizing center)|refseq:NP_598516.2	-	-	-	comment:For the Hdac5 isolations in whole brain, a uniform threshold of ≥0.7 was applied for all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|figure legend:ST3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/11/24	2020/11/25	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:rWPzsdt3ECnxr+ksi4MaH7okQ+M10090	rigid:x3OkpO2owSY9V3oyWjdkBAjVKn4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q7TQH0	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-6908203|ensembl:ENSMUSP00000035415|uniprotkb:Q80XN9|uniprotkb:Q8K059	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:atx2l_mouse(display_long)|uniprotkb:Atxn2l(gene name)|psi-mi:Atxn2l(display_short)|uniprotkb:A2lp(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:XP_006507788.1|ensembl:ENSMUSG00000032637(gene)|ensembl:ENSMUST00000040202(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010603"(regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0034063"(stress granule assembly)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR025852|mint:Q7TQH0|refseq:NP_898841.1	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:7v7iuPRti2err2QrmJIGoWqEM3U10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q80X66	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-26471043|ensembl:ENSMUSP00000048530	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:btbda_mouse(display_long)|uniprotkb:Btbd10(gene name)|psi-mi:Btbd10(display_short)|uniprotkb:Gmrp1(gene name synonym)|uniprotkb:Glucose metabolism-related protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	interpro:IPR011333(BTB/POZ fold)|interpro:IPR039885|interpro:IPR039886|mint:Q80X66|ensembl:ENSMUSG00000038187(gene)|ensembl:ENSMUST00000047091(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR000210(BTB/POZ-like)|refseq:NP_598461.1|refseq:XP_006508223.1|refseq:XP_011240192.1	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:VoTwPedMCjTuxDWUH5cbm1iIUQ410090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:P24270	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-2924912|uniprotkb:Q3TXQ6|ensembl:ENSMUSP00000028610	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:cata_mouse(display_long)|uniprotkb:Cat(gene name)|psi-mi:Cat(display_short)|uniprotkb:Cas-1(gene name synonym)|uniprotkb:Cas1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	go:"GO:0055093"(response to hyperoxia)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0080184"(response to phenylpropanoid)|interpro:IPR002226(Catalase)|interpro:IPR010582(Catalase-related)|interpro:IPR011614(Catalase, N-terminal)|interpro:IPR018028|interpro:IPR020835|interpro:IPR024708|interpro:IPR024711|interpro:IPR040333|mint:P24270|reactome:R-MMU-3299685|reactome:R-MMU-6798695|reactome:R-MMU-9033241|go:"GO:0051781"(positive regulation of cell division)|ensembl:ENSMUSG00000027187(gene)|ensembl:ENSMUST00000028610(transcript)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0004096"(catalase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009642"(response to light intensity)|go:"GO:0009650"(UV protection)|go:"GO:0010193"(response to ozone)|go:"GO:0010288"(response to lead ion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0016209"(antioxidant activity)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019899"(enzyme binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|refseq:NP_033934.2	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:Ahsw8/VMIQAUw7mWuBSFRn9g/3M10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q8CC12	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-26470848|ensembl:ENSMUSP00000106329|uniprotkb:A2AW10|uniprotkb:Q149P8|uniprotkb:Q3U032	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:cdan1_mouse(display_long)|uniprotkb:Cdan1(gene name)|psi-mi:Cdan1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	ensembl:ENSMUSG00000027284(gene)|ensembl:ENSMUST00000110701(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0008104"(protein localization)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031497"(chromatin assembly)|interpro:IPR028171|interpro:IPR040031|mint:Q8CC12|refseq:NP_081167.2	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:5Nyg/Fnh9WKYy3DFp/o8OTH4LGA10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q09XV5	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-1169080|uniprotkb:Q3TV89|uniprotkb:Q5I1Z2|uniprotkb:Q6ZPM8|ensembl:ENSMUSP00000087184|ensembl:ENSMUSP00000142890	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:chd8_mouse(display_long)|uniprotkb:Chd8(gene name)|psi-mi:Chd8(display_short)|uniprotkb:Kiaa1564(gene name synonym)|uniprotkb:ATP-dependent helicase CHD8(gene name synonym)|uniprotkb:Axis duplication inhibitor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_963999.2|refseq:XP_006519539.1|ensembl:ENSMUSG00000053754(gene)|ensembl:ENSMUST00000089752(transcript)|ensembl:ENSMUST00000200169(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035176"(social behavior)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048565"(digestive tract development)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070615"|go:"GO:0071339"(MLL1 complex)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000330(SNF2-related)|interpro:IPR000953(Chromo domain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023780|interpro:IPR027417|interpro:IPR034724|interpro:IPR037259|interpro:IPR038718|mint:Q09XV5|reactome:R-MMU-3769402	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:ZttrOvHiz/PMCKm+pScx4Tn1Af410090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q9D6G9	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-26470970|ensembl:ENSMUSP00000036138|uniprotkb:Q9DB66	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:cklf5_mouse(display_long)|uniprotkb:Cmtm5(gene name)|psi-mi:Cmtm5(display_short)|uniprotkb:Cklfsf5(gene name synonym)|uniprotkb:Chemokine-like factor superfamily member 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	ensembl:ENSMUSG00000040759(gene)|ensembl:ENSMUST00000037814(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045662"(negative regulation of myoblast differentiation)|interpro:IPR008253(Marvel)|mint:Q9D6G9|refseq:NP_080342.1|refseq:XP_017171651.1	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:Kj8DRGtMwsoKRnanvRkfzDr+4J810090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:O70133	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-2657677|uniprotkb:O35931|uniprotkb:O54703|uniprotkb:Q5FWY1|uniprotkb:Q6R5F7|uniprotkb:Q9CSA2	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:dhx9_mouse(display_long)|uniprotkb:Dhx9(gene name)|psi-mi:Dhx9(display_short)|uniprotkb:Ddx9(gene name synonym)|uniprotkb:Nuclear DNA helicase II(gene name synonym)|uniprotkb:DEAH box protein 9(gene name synonym)|uniprotkb:RNA helicase A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_031868.2|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR007502(Helicase-associated region)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001069"(regulatory region RNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005844"(polysome)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007623"(circadian rhythm)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016442"(RISC complex)|go:"GO:0016604"(nuclear body)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033679"(3'-5' DNA/RNA helicase activity)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045142"(triplex DNA binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0047429"(nucleoside-triphosphate diphosphatase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070269"(pyroptosis)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904973"(positive regulation of viral translation)|go:"GO:1905172"(RISC complex binding)|go:"GO:1905538"(polysome binding)|go:"GO:1905698"(positive regulation of polysome binding)|go:"GO:1990518"(single-stranded 3'-5' DNA helicase activity)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000765"(regulation of cytoplasmic translation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|rcsb pdb:1UIL|rcsb pdb:1WHQ|rcsb pdb:2RS6|rcsb pdb:2RS7|reactome:R-MMU-1810476|reactome:R-MMU-3134963|reactome:R-MMU-72163|interpro:IPR027417|mint:O70133|interpro:IPR044445|interpro:IPR044446|interpro:IPR044447	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:8NHxvbw0StglewhGm3e7Pi/8oOg10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:P70372	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-6877056|ensembl:ENSMUSP00000096549|ensembl:ENSMUSP00000146866|uniprotkb:Q60745|uniprotkb:Q78QY3	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:elav1_mouse(display_long)|uniprotkb:Elavl1(gene name)|psi-mi:Elavl1(display_short)|uniprotkb:Elra(gene name synonym)|uniprotkb:Hua(gene name synonym)|uniprotkb:Elav-like generic protein(gene name synonym)|uniprotkb:Hu-antigen R(gene name synonym)|uniprotkb:MelG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	ensembl:ENSMUSG00000040028(gene)|ensembl:ENSMUST00000098950(transcript)|ensembl:ENSMUST00000209010(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035198"(miRNA binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034996|interpro:IPR035979|mint:P70372|reactome:R-MMU-450520|reactome:R-MMU-72163|go:"GO:0019901"(protein kinase binding)|refseq:XP_006508761.1|refseq:NP_034615.2|dip:DIP-46480N	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:iKHrpZqi5b7EFLkfVJSRTpi9sj010090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q8C3F2	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-16728136|ensembl:ENSMUSP00000073082|uniprotkb:Q3U0F6	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:f120c_mouse(display_long)|uniprotkb:Protein FAM120C(gene name synonym)|uniprotkb:Fam120c(gene name)|psi-mi:Fam120c(display_short)|uniprotkb:ORF34(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	ensembl:ENSMUSG00000025262(gene)|go:"GO:0005634"(nucleus)|interpro:IPR026784|interpro:IPR026785|interpro:IPR029060|mint:Q8C3F2|ensembl:ENSMUST00000073364(transcript)|refseq:NP_932773.2	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:7t8xHEO+ShbLsdqIbH6xQm7UcPw10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q3TJZ6	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-8318357|intact:MINT-1858128|uniprotkb:Q99KJ2|ensembl:ENSMUSP00000108126	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:fa98a_mouse(display_long)|uniprotkb:Fam98a(gene name)|psi-mi:Fam98a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_598508.2|ensembl:ENSMUSG00000002017(gene)|ensembl:ENSMUST00000112507(transcript)|go:"GO:0006479"(protein methylation)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032418"(lysosome localization)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR018797|mint:Q3TJZ6	-	-	comment:mint	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:ZvcKhnXQtXNW4jEx2X8IvALCfZU10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q3UQN2	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-6094986|uniprotkb:Q3UJ91|uniprotkb:Q7TMS9|uniprotkb:Q8C0I2|ensembl:ENSMUSP00000042959	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:fcho2_mouse(display_long)|uniprotkb:Fcho2(gene name)|psi-mi:Fcho2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_766179.2|dip:DIP-29489N|ensembl:ENSMUSG00000041685(gene)|ensembl:ENSMUST00000040340(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0010324"(membrane invagination)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098835"(presynaptic endocytic zone membrane)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR018808|interpro:IPR027267|interpro:IPR028565|interpro:IPR030122|interpro:IPR031160|mint:Q3UQN2|reactome:R-MMU-8856825|reactome:R-MMU-8856828	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:0+FhOCmcIH+a08hD9KmSTtW5XDw10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q3U0V1	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-4282969|uniprotkb:Q2VPQ6|uniprotkb:Q6P2L2|uniprotkb:E9QKH3|ensembl:ENSMUSP00000007814	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:fubp2_mouse(display_long)|uniprotkb:Khsrp(gene name)|psi-mi:Khsrp(display_short)|uniprotkb:Fubp2(gene name synonym)|uniprotkb:KH type-splicing regulatory protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_034743.3|ensembl:ENSMUSG00000007670(gene)|ensembl:ENSMUST00000007814(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0030425"(dendrite)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0051028"(mRNA transport)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000628"(regulation of miRNA metabolic process)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR015096(Region of unknown function DUF1897)|interpro:IPR036612|mint:Q3U0V1|reactome:R-MMU-450604	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:snMZYaCxr5k/zzbgZD18vz5RAfs10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:P39087	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-396914|uniprotkb:Q60933|ensembl:ENSMUSP00000101124|ensembl:ENSMUSP00000151921	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:grik2_mouse(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym)|uniprotkb:Glutamate receptor beta-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:XP_017169293.1|ensembl:ENSMUSG00000056073(gene)|ensembl:ENSMUST00000105484(transcript)|ensembl:ENSMUST00000218823(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|mint:P39087|reactome:R-MMU-451307|reactome:R-MMU-451308	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:6sgY8SzX07HzilLLeDg3pV+sXkc10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q8BWS5	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-26472832|ensembl:ENSMUSP00000051805|uniprotkb:Q69Z30	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:grin3_mouse(display_long)|uniprotkb:Gprin3(gene name)|psi-mi:Gprin3(display_short)|uniprotkb:Kiaa2027(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	ensembl:ENSMUSG00000045441(gene)|ensembl:ENSMUST00000051065(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0031175"(neuron projection development)|interpro:IPR026646|interpro:IPR032745|mint:Q8BWS5|refseq:NP_899006.1	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:TUt7HEqIihPNC+yWsH42oCCXRVQ10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q6NZM9	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q8R081	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-647483|uniprotkb:O54789|uniprotkb:Q8K0S7|uniprotkb:Q499X2|ensembl:ENSMUSP00000049407|ensembl:ENSMUSP00000133728	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:hnrpl_mouse(display_long)|uniprotkb:Hnrpl(gene name synonym)|uniprotkb:Hnrnpl(gene name)|psi-mi:Hnrnpl(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_796275.3|refseq:XP_006539621.1|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006536(HnRNP-L/PTB/hephaestus splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021790|interpro:IPR034816|interpro:IPR034817|interpro:IPR035005|interpro:IPR035008|interpro:IPR035979|mint:Q8R081|rcsb pdb:3S01|rcsb pdb:3TYT|reactome:R-MMU-72163|reactome:R-MMU-72203|go:"GO:1990715"(mRNA CDS binding)|ensembl:ENSMUSG00000015165(gene)|ensembl:ENSMUST00000038572(transcript)|ensembl:ENSMUST00000174548(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0045120"(pronucleus)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0097157"(pre-mRNA intronic binding)|go:"GO:1902416"(positive regulation of mRNA binding)	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:BApt4fekoyJ285Ve13kxstcLbV010090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q7TMK9	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-2735641|uniprotkb:O88991|uniprotkb:Q2YDV8|uniprotkb:Q68ED6|uniprotkb:Q80YV6|uniprotkb:Q8BGP1|uniprotkb:Q8C5K6|uniprotkb:Q8CGC2|uniprotkb:Q91ZR0|uniprotkb:Q99KU9|uniprotkb:Q9QYF4|ensembl:ENSMUSP00000133649	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:hnrpq_mouse(display_long)|uniprotkb:Syncrip(gene name)|psi-mi:Syncrip(display_short)|uniprotkb:Hnrpq(gene name synonym)|uniprotkb:Nsap1(gene name synonym)|uniprotkb:Nsap1l(gene name synonym)|uniprotkb:Synaptotagmin-binding, cytoplasmic RNA-interacting protein(gene name synonym)|uniprotkb:Glycine- and tyrosine-rich RNA-binding protein(gene name synonym)|uniprotkb:NS1-associated protein 1(gene name synonym)|uniprotkb:pp68(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_001271257.1|refseq:NP_062640.2|refseq:NP_062770.1|refseq:NP_001298042.1|ensembl:ENSMUSG00000032423(gene)|ensembl:ENSMUST00000173801(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006397"(mRNA processing)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006535(HnRNP R and Q splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034544|interpro:IPR034548|interpro:IPR035979|interpro:IPR041337|mint:Q7TMK9	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:Ljuz8koebOL7L9jFBaevQYHinzw10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:P59325	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-8312397|ensembl:ENSMUSP00000061616|ensembl:ENSMUSP00000126825|ensembl:ENSMUSP00000152791|intact:MINT-1857485	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:if5_mouse(display_long)|uniprotkb:Eif5(gene name)|psi-mi:Eif5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	ensembl:ENSMUSG00000021282(gene)|ensembl:ENSMUST00000050993(transcript)|ensembl:ENSMUST00000166123(transcript)|ensembl:ENSMUST00000222375(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|mint:P59325|reactome:R-MMU-72702|reactome:R-MMU-72706|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|refseq:NP_829887.1|refseq:NP_775539.1	-	-	comment:mint|function:"Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F])"	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:OQ4olrPlHrkjB/J46gKEVh4EEyY10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q9CXY6	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-2312782|uniprotkb:Q3U083|uniprotkb:Q5RKG0|uniprotkb:Q8CCY9|uniprotkb:Q99KS3|ensembl:ENSMUSP00000001042	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:ilf2_mouse(display_long)|uniprotkb:Ilf2(gene name)|psi-mi:Ilf2(display_short)|uniprotkb:Nf45(gene name synonym)|uniprotkb:Nuclear factor of activated T-cells 45 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_080650.1|ensembl:ENSMUSG00000001016(gene)|ensembl:ENSMUST00000001042(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR043519|mint:Q9CXY6|rcsb pdb:4AT7|rcsb pdb:4AT8|rcsb pdb:4AT9|rcsb pdb:4ATB|reactome:R-MMU-6798695	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:HwUDuY6Ev7csoTThxZCW8nJT88o10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q9Z1X4	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-6260790|ensembl:ENSMUSP00000065770|uniprotkb:Q8BP80|uniprotkb:Q8K588|uniprotkb:Q8C2H8|uniprotkb:Q812A1|uniprotkb:Q80VD5	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:ilf3_mouse(display_long)|uniprotkb:Ilf3(gene name)|psi-mi:Ilf3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_001264250.1|ensembl:ENSMUSG00000032178(gene)|ensembl:ENSMUST00000067646(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006479"(protein methylation)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR033099|interpro:IPR043519|mint:Q9Z1X4|rcsb pdb:4AT7|rcsb pdb:4AT8|rcsb pdb:4AT9|rcsb pdb:4ATB|rcsb pdb:5DV7|refseq:XP_006510094.1|refseq:NP_001036172.1|refseq:NP_001036173.1|refseq:NP_034691.2|refseq:NP_001264251.1	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:vxZan3L6NAseX1Ib9Z7MQ82CM3E10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q9JHU9	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-1634601|ensembl:ENSMUSP00000019283|ensembl:ENSMUSP00000148077	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:ino1_mouse(display_long)|uniprotkb:Isyna1(gene name)|psi-mi:Isyna1(display_short)|uniprotkb:Ino1(gene name synonym)|uniprotkb:Myo-inositol 1-phosphate synthase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_076116.1|ensembl:ENSMUSG00000019139(gene)|ensembl:ENSMUST00000019283(transcript)|ensembl:ENSMUST00000210005(transcript)|go:"GO:0004512"(inositol-3-phosphate synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006021"(inositol biosynthetic process)|go:"GO:0008654"(phospholipid biosynthetic process)|interpro:IPR002587(Myo-inositol-1-phosphate synthase)|interpro:IPR013021(Myo-inositol-1-phosphate synthase, GAPDH-like)|interpro:IPR036291|mint:Q9JHU9|reactome:R-MMU-1855183	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:2sC3BHRnI9YSxfIHmbuI27e0TJU10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:P11881	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-541478|uniprotkb:P20943|uniprotkb:Q99LG5|ensembl:ENSMUSP00000032192	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:itpr1_mouse(display_long)|uniprotkb:Type 1 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 1(gene name synonym)|uniprotkb:Inositol 1,4,5-trisphosphate-binding protein P400(gene name synonym)|uniprotkb:Purkinje cell protein 1(gene name synonym)|uniprotkb:Protein PCD-6(gene name synonym)|uniprotkb:Itpr1(gene name)|psi-mi:Itpr1(display_short)|uniprotkb:Insp3r(gene name synonym)|uniprotkb:Pcd6(gene name synonym)|uniprotkb:Pcp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_034715.3|refseq:XP_006505693.1|refseq:XP_006505699.1|refseq:XP_006505700.1|dip:DIP-32243N|refseq:XP_017176897.1|refseq:XP_017176899.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0098794"(postsynapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|mint:P11881|rcsb pdb:1N4K|rcsb pdb:1XZZ|rcsb pdb:5GUG|rcsb pdb:5X9Z|rcsb pdb:5XA0|rcsb pdb:5XA1|reactome:R-MMU-114508|reactome:R-MMU-139853|reactome:R-MMU-381676|reactome:R-MMU-418457|reactome:R-MMU-5578775|reactome:R-MMU-983695|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097421"(liver regeneration)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098695"(inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels)|go:"GO:0098793"(presynapse)|ensembl:ENSMUSG00000030102(gene)|ensembl:ENSMUST00000032192(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:O+LA4/Acwos+RNtyqL3IgAe/kkk10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q08460	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q6ZPR4	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-16728165|ensembl:ENSMUSP00000109809|uniprotkb:B2RUK3|uniprotkb:Q8C3E7	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:kcnt1_mouse(display_long)|uniprotkb:Kcnt1(gene name)|psi-mi:Kcnt1(display_short)|uniprotkb:Kiaa1422(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	ensembl:ENSMUSG00000058740(gene)|ensembl:ENSMUST00000114172(transcript)|go:"GO:0005228"(intracellular sodium activated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR013099(Ion transport 2)|mint:Q6ZPR4|refseq:NP_001289280.1|refseq:NP_780671.2	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:dqty8xDH9pIQhzgbYTeSOo4tLjA10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:P28741	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-6169413|ensembl:ENSMUSP00000112782|uniprotkb:Q7TSZ7	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:kif3a_mouse(display_long)|uniprotkb:Kif3a(gene name)|psi-mi:Kif3a(display_short)|uniprotkb:Kif3(gene name synonym)|uniprotkb:Microtubule plus end-directed kinesin motor 3A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	ensembl:ENSMUSG00000018395(gene)|ensembl:ENSMUST00000120613(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001947"(heart looping)|go:"GO:0003341"(cilium movement)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008544"(epidermis development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0015031"(protein transport)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016939"(kinesin II complex)|go:"GO:0019894"(kinesin binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021915"(neural tube development)|go:"GO:0030507"(spectrin binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031514"(motile cilium)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0036334"(epidermal stem cell homeostasis)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060271"(cilium assembly)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0120170"(intraciliary transport particle B binding)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905128"(positive regulation of axo-dendritic protein transport)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990939"|go:"GO:2000771"(positive regulation of establishment or maintenance of cell polarity regulating cell shape)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:P28741|rcsb pdb:5JVR|rcsb pdb:5JX1|reactome:R-MMU-2132295|reactome:R-MMU-5610787|reactome:R-MMU-5620924|reactome:R-MMU-5635838|reactome:R-MMU-983189|reactome:R-MMU-6811434|refseq:NP_001277734.1|refseq:NP_001277735.1|refseq:NP_032469.2|dip:DIP-46318N	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:3P8b4UgzwNTTXf1KVCB6+T+1+bk10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:P18826	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-26470825|ensembl:ENSMUSP00000061991|uniprotkb:A2AI90	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:kpb1_mouse(display_long)|uniprotkb:Phka1(gene name)|psi-mi:Phka1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	ensembl:ENSMUSG00000034055(gene)|ensembl:ENSMUST00000052012(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR008734(Phosphorylase kinase alphabeta)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR011613(Glycoside hydrolase 15-related)|interpro:IPR012341(Six-hairpin glycosidase)|mint:P18826|reactome:R-MMU-70221|refseq:NP_032858.2	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:m6KkLpQv72gScTWLDJ2f1g4mtuo10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q7TSH2	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-911437|ensembl:ENSMUSP00000050788	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:kpbb_mouse(display_long)|uniprotkb:Phkb(gene name)|psi-mi:Phkb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_955517.1|ensembl:ENSMUSG00000036879(gene)|ensembl:ENSMUST00000053771(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|interpro:IPR008734(Phosphorylase kinase alphabeta)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR011613(Glycoside hydrolase 15-related)|mint:Q7TSH2|reactome:R-MMU-70221|refseq:XP_006530595.1|refseq:XP_006530596.1|refseq:XP_006530597.1	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:qRovReuecws5KcJl6XVcnVO5FW410090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q6S5J6	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-21986340|uniprotkb:Q6VSV2|uniprotkb:Q7TPR8|uniprotkb:Q8C9Q6|uniprotkb:Q9EPY2|uniprotkb:Q9ERH0|ensembl:ENSMUSP00000078985	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:krit1_mouse(display_long)|uniprotkb:Krit1(gene name)|psi-mi:Krit1(display_short)|uniprotkb:Ccm1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_001164023.1|refseq:NP_109600.2|refseq:XP_006503680.1|refseq:XP_006503681.1|ensembl:ENSMUSG00000000600(gene)|ensembl:ENSMUST00000080085(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|mint:Q6S5J6	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:kvkc7EGV6HR7ov6b4gWTipkmEX410090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q5XJV6	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-16726286|uniprotkb:A6BLZ0|uniprotkb:Q52KF1	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:lmtk3_mouse(display_long)|uniprotkb:Apoptosis-associated tyrosine kinase 3(gene name synonym)|uniprotkb:Lemur tyrosine kinase 3(gene name synonym)|uniprotkb:Lmtk3(gene name)|psi-mi:Lmtk3(display_short)|uniprotkb:Aatyk3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|mint:Q5XJV6|refseq:NP_001005511.2|refseq:NP_001277919.1|refseq:XP_006541027.1|refseq:XP_017177816.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:FJgk1CZB0wgIbl5dhC81Wy7TRJE10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:O35099	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-777493|uniprotkb:Q14AY5|ensembl:ENSMUSP00000093485	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:m3k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:Map3k5(gene name)|psi-mi:Map3k5(display_short)|uniprotkb:Ask1(gene name synonym)|uniprotkb:Mekk5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_032606.4|dip:DIP-38055N|ensembl:ENSMUSG00000071369(gene)|ensembl:ENSMUST00000095806(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010941"(regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902170"(cellular response to reactive nitrogen species)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:O35099|reactome:R-MMU-2559580	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:i1P8YtUNmpFauFUVVxzsMYoQYOw10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q8K310	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-1216295|ensembl:ENSMUSP00000125761|ensembl:ENSMUSP00000158074|ensembl:ENSMUSP00000158537	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:matr3_mouse(display_long)|uniprotkb:Matr3(gene name)|psi-mi:Matr3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_034901.2|rcsb pdb:1X4F|rcsb pdb:1X4D|ensembl:ENSMUSG00000037236(gene)|ensembl:ENSMUST00000166793(transcript)|ensembl:ENSMUST00000235199(transcript)|ensembl:ENSMUST00000237744(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034928|interpro:IPR034930|interpro:IPR035979|mint:Q8K310	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:AwtFbI+oRfha+mn/v3yzG6bNXYg10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:P56942	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-26450331|ensembl:ENSMUSP00000044352|uniprotkb:Q9D220	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:mch_mouse(display_long)|uniprotkb:Pmch(gene name)|psi-mi:Pmch(display_short)|uniprotkb:Mch(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	ensembl:ENSMUST00000048621(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007631"(feeding behavior)|go:"GO:0009409"(response to cold)|go:"GO:0030354"(melanin-concentrating hormone activity)|go:"GO:0031777"(type 1 melanin-concentrating hormone receptor binding)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042756"(drinking behavior)|go:"GO:0045202"(synapse)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046005"(positive regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|interpro:IPR005456(Pre-pro melanin-concentrating hormone)|mint:P56942|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUSG00000035383(gene)|refseq:NP_084247.1	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:l3UbZeUaSJTBhc0jao6eg+D8Q4U10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q8C854	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-4285350|uniprotkb:Q6ZPT3|uniprotkb:Q8QZZ1|uniprotkb:Q60690|uniprotkb:Q6P930|ensembl:ENSMUSP00000123088	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:myef2_mouse(display_long)|uniprotkb:Myef2(gene name)|psi-mi:Myef2(display_short)|uniprotkb:Kiaa1341(gene name synonym)|uniprotkb:Mef2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_001155889.1|refseq:XP_006498947.1|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034630|interpro:IPR034631|interpro:IPR034632|interpro:IPR035979|interpro:IPR000504(RNA recognition motif, RNP-1)|mint:Q8C854|ensembl:ENSMUSG00000027201(gene)|ensembl:ENSMUST00000152367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000815"(regulation of mRNA stability involved in response to oxidative stress)|refseq:XP_017171620.1|refseq:XP_017171621.1|refseq:XP_017171623.1	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:ZnM8NqQUhlLdO7gzhs09ckrZUPw10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q80UM3	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-2554211|uniprotkb:Q9JID5|uniprotkb:Q811Z9	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:naa15_mouse(display_long)|uniprotkb:Narg1(gene name synonym)|uniprotkb:NMDA receptor-regulated protein 1(gene name synonym)|uniprotkb:Naa15(gene name)|psi-mi:Naa15(display_short)|uniprotkb:Nat1(gene name synonym)|uniprotkb:Tbdn-1(gene name synonym)|uniprotkb:Tubedown(gene name synonym)|uniprotkb:N-terminal acetyltransferase 1(gene name synonym)|uniprotkb:Protein tubedown-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	interpro:IPR021183|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|go:"GO:0001525"(angiogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017196"(N-terminal peptidyl-methionine acetylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031415"(NatA complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0006474"(N-terminal protein amino acid acetylation)|mint:Q80UM3	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:hE4GwKw45rlC8XVDGmigsauWJMU10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q62443	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-26470897|ensembl:ENSMUSP00000026670	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:nptx1_mouse(display_long)|uniprotkb:Nptx1(gene name)|psi-mi:Nptx1(display_short)|uniprotkb:Neuronal pentraxin I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	ensembl:ENSMUSG00000025582(gene)|ensembl:ENSMUST00000026670(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0030133"(transport vesicle)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|mint:Q62443|refseq:NP_032756.1	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:ddE8h5JD7XtrGle7yD9q+E4m/co10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q99J85	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-8311244|intact:MINT-4104086	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:nptxr_mouse(display_long)|uniprotkb:Nptxr(gene name)|psi-mi:Nptxr(display_short)|uniprotkb:Npr(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0008029"(pentraxin receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099150"(regulation of postsynaptic specialization assembly)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR030476|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|mint:Q99J85	-	-	comment:mint	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:AWabDfkkTcL+AMgJlRt5ntbJ5WU10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:B2RRE7	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-16728605|ensembl:ENSMUSP00000133939|uniprotkb:B7ZNI5|uniprotkb:Q80TL3|uniprotkb:Q9CUN2	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:otud4_mouse(display_long)|uniprotkb:Otud4(gene name)|psi-mi:Otud4(display_short)|uniprotkb:Kiaa1046(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	ensembl:ENSMUSG00000036990(gene)|ensembl:ENSMUST00000173078(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|mint:B2RRE7|refseq:NP_001074633.1|refseq:NP_001242962.1	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:hvTooCUd0wIF+PvtoaDsmYWo4/s10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:P07934	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-26470873|ensembl:ENSMUSP00000026617	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:phkg1_mouse(display_long)|uniprotkb:Phkg1(gene name)|psi-mi:Phkg1(display_short)|uniprotkb:Phkg(gene name synonym)|uniprotkb:Phosphorylase kinase subunit gamma-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PHKG1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	ensembl:ENSMUST00000026617(transcript)|go:"GO:0004689"(phosphorylase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR002291(Phosphorylase kinase, gamma catalytic subunit)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P07934|reactome:R-MMU-70221|ensembl:ENSMUSG00000025537(gene)|refseq:NP_035209.1	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:oWhiqhcqtIelRPU5Z0TI4T9lskc10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q99JY8	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-773683|uniprotkb:Q3TVM4|uniprotkb:Q3TXR7|uniprotkb:Q8BTB7|ensembl:ENSMUSP00000065719	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:plpp3_mouse(display_long)|uniprotkb:Plpp3(gene name)|psi-mi:Plpp3(display_short)|uniprotkb:Lipid phosphate phosphohydrolase 3(gene name synonym)|uniprotkb:Lpp3(gene name synonym)|uniprotkb:PAP2-beta(gene name synonym)|uniprotkb:Phosphatidate phosphohydrolase type 2b(gene name synonym)|uniprotkb:Phosphatidic acid phosphatase 2b(gene name synonym)|uniprotkb:Ppap2b(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_542122.1|ensembl:ENSMUSG00000028517(gene)|ensembl:ENSMUST00000064139(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001568"(blood vessel development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005178"(integrin binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006670"(sphingosine metabolic process)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008195"(phosphatidate phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042392"(sphingosine-1-phosphate phosphatase activity)|go:"GO:0042577"(lipid phosphatase activity)|go:"GO:0044328"(canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration)|go:"GO:0044329"(canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion)|go:"GO:0044330"(canonical Wnt signaling pathway involved in positive regulation of wound healing)|go:"GO:0045121"(membrane raft)|go:"GO:0046839"(phospholipid dephosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0106235"(ceramide-1-phosphate phosphatase activity)|go:"GO:1902068"(regulation of sphingolipid mediated signaling pathway)|interpro:IPR000326(Phosphatidic acid phosphatase type 2/haloperoxidase)|interpro:IPR028675|interpro:IPR036938|interpro:IPR043216|mint:Q99JY8|reactome:R-MMU-1660661	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:k0j2BFjYFftNCFSr6/PrQfurHck10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q7TSC1	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-645425|uniprotkb:Q923A9|uniprotkb:Q9Z1R1|ensembl:ENSMUSP00000025253	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:prc2a_mouse(display_long)|uniprotkb:HLA-B-associated transcript 2(gene name synonym)|uniprotkb:Prrc2a(gene name)|psi-mi:Prrc2a(display_short)|uniprotkb:Bat2(gene name synonym)|uniprotkb:Proline-rich and coiled-coil-containing protein 2A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_001185973.1|refseq:NP_064411.2|refseq:XP_006524683.1|dip:DIP-49629N|ensembl:ENSMUSG00000024393(gene)|ensembl:ENSMUST00000025253(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030154"(cell differentiation)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:Q7TSC1	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:ktwyGkClOoaD4rZap/xJb/aKj4s10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q3TLH4	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-6908845|ensembl:ENSMUSP00000138433|uniprotkb:E9QKG5|uniprotkb:Q05CS4|uniprotkb:Q05DM5|uniprotkb:Q3TKF3|uniprotkb:Q3UXU5|uniprotkb:Q4FZE4|uniprotkb:Q66K03|uniprotkb:Q6P3F4|uniprotkb:Q80TK3|uniprotkb:Q80YR0|uniprotkb:Q8BMJ4|uniprotkb:Q8C1K7|uniprotkb:Q8CGH3	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:prc2c_mouse(display_long)|uniprotkb:Prrc2c(gene name)|psi-mi:Prrc2c(display_short)|uniprotkb:Bat2d(gene name synonym)|uniprotkb:Bat2d1(gene name synonym)|uniprotkb:Bat2l2(gene name synonym)|uniprotkb:Kiaa1096(gene name synonym)|uniprotkb:BAT2 domain-containing protein 1(gene name synonym)|uniprotkb:HLA-B-associated transcript 2-like 2(gene name synonym)|uniprotkb:Proline-rich and coiled-coil-containing protein 2C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:XP_011237086.1|ensembl:ENSMUSG00000040225(gene)|ensembl:ENSMUST00000182660(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0034063"(stress granule assembly)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:Q3TLH4|refseq:NP_001074759.1	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:lJHI4KKm0yJpyg2mURs2zCXOrSY10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q9EPU0	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-6876715|ensembl:ENSMUSP00000075089|uniprotkb:Q3UG00|uniprotkb:Q6GYP5|uniprotkb:Q6PHQ5|uniprotkb:Q8K0N4|uniprotkb:Q99PR4	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:rent1_mouse(display_long)|uniprotkb:Upf1(gene name)|psi-mi:Upf1(display_short)|uniprotkb:Rent1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	ensembl:ENSMUSG00000058301(gene)|ensembl:ENSMUST00000075666(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016787"(hydrolase activity)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR018999|interpro:IPR027417|interpro:IPR040812|interpro:IPR041677|interpro:IPR041679|mint:Q9EPU0|reactome:R-MMU-975956|reactome:R-MMU-975957|go:"GO:0042162"(telomeric DNA binding)|refseq:XP_006509667.1|refseq:XP_006509668.1|refseq:NP_001116301.1|refseq:NP_109605.2|dip:DIP-60114N	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:rwd4XXdf5Uqjtgao/zILckKP8AM10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q8BIF2	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-4567146|uniprotkb:A2A4W8|uniprotkb:B7ZC12|uniprotkb:Q3TUE0|uniprotkb:Q7TQI4|uniprotkb:A2A4W7|uniprotkb:B7ZC13|uniprotkb:D1GI07|ensembl:ENSMUSP00000017576	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:rfox3_mouse(display_long)|uniprotkb:Rbfox3(gene name)|psi-mi:Rbfox3(display_short)|uniprotkb:D11Bwg0517e(gene name synonym)|uniprotkb:Fox-1 homolog C(gene name synonym)|uniprotkb:Hexaribonucleotide-binding protein 3(gene name synonym)|uniprotkb:Hrnbp3(gene name synonym)|uniprotkb:Neuronal nuclei antigen(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_001272365.1|refseq:NP_001272366.1|refseq:NP_001272367.1|refseq:NP_001020102.2|refseq:NP_001034256.1|refseq:NP_001034257.1|refseq:XP_006533785.1|refseq:XP_006533788.1|refseq:XP_006533790.1|refseq:XP_017170150.1|refseq:XP_017170151.1|refseq:XP_017170152.1|ensembl:ENSMUSG00000025576(gene)|ensembl:ENSMUST00000017576(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007399"(nervous system development)|go:"GO:0008380"(RNA splicing)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017325(RNA-binding protein 9/Ataxin-2-binding protein)|interpro:IPR025670|interpro:IPR034237|interpro:IPR035979|mint:Q8BIF2	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:eTt38jd3Cz7j0FBtUxSa1Ip6SIQ10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q8BVY0	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-8339028|uniprotkb:Q8K235|intact:MINT-4112887|ensembl:ENSMUSP00000113431	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:rl1d1_mouse(display_long)|uniprotkb:Rsl1d1(gene name)|psi-mi:Rsl1d1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_079822.1|ensembl:ENSMUSG00000005846(gene)|ensembl:ENSMUST00000119953(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0030686"(90S preribosome)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR016095(Ribosomal protein L1, 3-layer alpha/beta-sandwich)|interpro:IPR023674|interpro:IPR028364|mint:Q8BVY0	-	-	comment:mint	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:dvktZG7E05exciHtyzN7bS+rRvc10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q6NZL8	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-7364500|uniprotkb:Q9EQC6|intact:MINT-4653211|uniprotkb:Q8C9Q4|ensembl:ENSMUSP00000016907	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:scub1_mouse(display_long)|uniprotkb:Scube1(gene name)|psi-mi:Scube1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_073560.2|refseq:NP_001258401.1|ensembl:ENSMUSG00000016763(gene)|ensembl:ENSMUST00000016907(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR018097|interpro:IPR024731|interpro:IPR026823|interpro:IPR035914|mint:Q6NZL8|reactome:R-MMU-1474228	-	-	comment:mint|function:Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:7xFgdlcD91RMiaKWtWbcZoHHf4Y10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q80U23	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-8334059|uniprotkb:A2AT08|uniprotkb:A2AT09|uniprotkb:A2AT11|uniprotkb:A4FUV3|uniprotkb:A4VCI7|uniprotkb:Q4VA51|uniprotkb:Q8C8B8|uniprotkb:A2AT10|intact:MINT-4114767|uniprotkb:Q6GQX4|ensembl:ENSMUSP00000092026	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:snph_mouse(display_long)|uniprotkb:Snph(gene name)|psi-mi:Snph(display_short)|uniprotkb:Kiaa0374(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:XP_011237840.1|refseq:NP_937857.1|refseq:NP_001278005.1|refseq:NP_001278006.1|ensembl:ENSMUSG00000027457(gene)|ensembl:ENSMUST00000094456(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045806"(negative regulation of endocytosis)|interpro:IPR026196|interpro:IPR028197|mint:Q80U23	-	-	function:Inhibits SNARE complex formation by absorbing free syntaxin-1|comment:mint	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:koJOoOh2nblMekK07E7dg+8csqg10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q64105	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-26470795|uniprotkb:Q63996	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:spre_mouse(display_long)|uniprotkb:Spr(gene name)|psi-mi:Spr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	go:"GO:0004757"(sepiapterin reductase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006558"(L-phenylalanine metabolic process)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0010033"(response to organic substance)|go:"GO:0019889"(pteridine metabolic process)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046146"(tetrahydrobiopterin metabolic process)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050882"(voluntary musculoskeletal movement)|rcsb pdb:1NAS|rcsb pdb:1OAA|rcsb pdb:1SEP|reactome:R-MMU-1474151|reactome:R-MMU-203615|mint:Q64105|interpro:IPR036291|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR006393(Sepiapterin reductase)	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:Y4ePCWcq2RI0t59kgHibLyHd6yM10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q91WM1	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-8339684|intact:MINT-4121401|uniprotkb:Q62262|ensembl:ENSMUSP00000028279|ensembl:ENSMUSP00000072047	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:strbp_mouse(display_long)|uniprotkb:Strbp(gene name)|psi-mi:Strbp(display_short)|uniprotkb:Spnr(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:XP_011237348.1|refseq:XP_011237349.1|refseq:NP_033287.2|refseq:XP_017172309.1|refseq:XP_017172310.1|refseq:XP_017172311.1|refseq:XP_017172312.1|ensembl:ENSMUSG00000026915(gene)|ensembl:ENSMUST00000028279(transcript)|ensembl:ENSMUST00000072186(transcript)|go:"GO:0002177"(manchette)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0007638"(mechanosensory behavior)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR030446|interpro:IPR043519|interpro:IPR044472|mint:Q91WM1	-	-	comment:mint|function:"Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth (By similarity). Binds to double-stranded DNA and RNA (By similarity). Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA (By similarity). Binds also to single-stranded poly(G) RNA (By similarity). Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA"	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:+sf/OyoCMvzDmHmCmq4Me4jWjco10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:O35681	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-457995|uniprotkb:P97791|uniprotkb:Q80WV1	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:syt3_mouse(display_long)|uniprotkb:Syt3(gene name)|psi-mi:Syt3(display_short)|uniprotkb:Synaptotagmin III(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_001107588.1|refseq:NP_057872.3|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR028682|mint:O35681|interpro:IPR035892	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:mkfffZn3WWGhztw/udRiKd0LUJ010090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q3UHK6	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-773013|uniprotkb:O70465|uniprotkb:Q3TSI0|uniprotkb:Q3UH52|uniprotkb:Q80TF5|uniprotkb:Q9WTS7	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:ten4_mouse(display_long)|uniprotkb:Tenm4(gene name)|psi-mi:Tenm4(display_short)|uniprotkb:Doc4(gene name synonym)|uniprotkb:Downstream of CHOP4(gene name synonym)|uniprotkb:Kiaa1302(gene name synonym)|uniprotkb:Odz4(gene name synonym)|uniprotkb:Protein Odd Oz/ten-m homolog 4(gene name synonym)|uniprotkb:Tenascin-M4(gene name synonym)|uniprotkb:Teneurin transmembrane protein 4(gene name synonym)|uniprotkb:Tnm4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	interpro:IPR031325|refseq:NP_001297689.1|refseq:NP_001297691.1|refseq:NP_035988.2|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR008969(Carboxypeptidase-like, regulatory region)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR013111(EGF, extracellular)|interpro:IPR022385|interpro:IPR009471(Teneurin intracellular, N-terminal)|interpro:IPR006530(YD repeat)|interpro:IPR028916|refseq:XP_017177717.1|interpro:IPR027691|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048666"(neuron development)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060912"(cardiac cell fate specification)|go:"GO:2000543"(positive regulation of gastrulation)|mint:Q3UHK6	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:0oVMre4l1F1JwL4Gu0Uz8P2bDew10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q69ZU6	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-9673461|uniprotkb:Q3TP01|uniprotkb:Q3UWV1	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:ths7a_mouse(display_long)|uniprotkb:Thsd7a(gene name)|psi-mi:Thsd7a(display_short)|uniprotkb:Gm837(gene name synonym)|uniprotkb:Kiaa0960(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	mint:Q69ZU6|interpro:IPR000884(Thrombospondin, type I)|refseq:NP_001158277.1|interpro:IPR036383|interpro:IPR044004|go:"GO:0001525"(angiogenesis)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0098846"(podocyte foot)|reactome:R-MMU-5173214	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:/qTgHz4eRmV8fo7eOtIiStWEzrw10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q7TSH8	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-26472811|ensembl:ENSMUSP00000091440|ensembl:ENSMUSP00000099322|uniprotkb:B1AT99|uniprotkb:Q80U66|uniprotkb:Q8BL05|uniprotkb:Q8K0Q0|uniprotkb:Q91VY1	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:tmm94_mouse(display_long)|uniprotkb:Tmem94(gene name)|psi-mi:Tmem94(display_short)|uniprotkb:Kiaa0195(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	ensembl:ENSMUSG00000020747(gene)|ensembl:ENSMUST00000093912(transcript)|ensembl:ENSMUST00000103033(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR023298|interpro:IPR039720|mint:Q7TSH8|refseq:NP_082290.2|refseq:XP_006534334.1	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:SezB013NdM523ZcLeFSR4GlwMrY10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:Q9Z321	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-16728364|ensembl:ENSMUSP00000023465|ensembl:ENSMUSP00000156132	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:top3b_mouse(display_long)|uniprotkb:DNA topoisomerase III beta-1(gene name synonym)|uniprotkb:Top3b(gene name)|psi-mi:Top3b(display_short)|uniprotkb:Top3b1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	ensembl:ENSMUSG00000022779(gene)|ensembl:ENSMUST00000023465(transcript)|ensembl:ENSMUST00000232581(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003916"(DNA topoisomerase activity)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007059"(chromosome segregation)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|mint:Q9Z321|refseq:NP_001313505.1|refseq:NP_035754.1|refseq:XP_006522054.1|refseq:XP_006522055.1|refseq:XP_006522057.1|refseq:XP_006522058.1|refseq:XP_017172426.1	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:9m6mpZ7aIV3fx3bU6opc3sFN3SA10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:P35441	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-6171593	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:tsp1_mouse(display_long)|uniprotkb:Thbs1(gene name)|psi-mi:Thbs1(display_short)|uniprotkb:Tsp1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0043236"(laminin binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|reactome:R-MMU-114608|reactome:R-MMU-186797|reactome:R-MMU-216083|reactome:R-MMU-5173214|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016477"(cell migration)|interpro:IPR001881(EGF-like calcium-binding)|mint:P35441|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR017897|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:0j9TPpvxNW9TNMFkFCNo+9wD3fA10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:B2RR83	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-8572369|ensembl:ENSMUSP00000048340|intact:MINT-8174232	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:ytdc2_mouse(display_long)|uniprotkb:Keen to exit meiosis leaving testes under-populated protein(gene name synonym)|uniprotkb:YTH domain-containing protein C2(gene name synonym)|uniprotkb:Ythdc2(gene name)|psi-mi:Ythdc2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR007275(YT521-B-like protein)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031083|interpro:IPR034083|interpro:IPR036770|interpro:IPR036867|mint:B2RR83|ensembl:ENSMUSG00000034653(gene)|ensembl:ENSMUST00000037763(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007286"(spermatid development)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048599"(oocyte development)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR001374(Single-stranded nucleic acid binding R3H)|refseq:NP_001156485.1	-	-	comment:mint	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:TxNENB71AFsznI6fFqBPUX8pgdA10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9CQE6	uniprotkb:O88532	intact:EBI-2657826|ensembl:ENSMUSP00000020004	intact:EBI-645485|uniprotkb:Q3TY30|uniprotkb:Q8BS85|uniprotkb:Q8CGG5|uniprotkb:Q91VZ0|uniprotkb:Q9CT34|ensembl:ENSMUSP00000118911	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:zfr_mouse(display_long)|uniprotkb:Zfr(gene name)|psi-mi:Zfr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472808|imex:IM-28526-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	refseq:NP_035897.2|ensembl:ENSMUSG00000022201(gene)|ensembl:ENSMUST00000122941(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR006561(DZF)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043519|mint:O88532	-	-	-	comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rogid:ncNwFUEUk0r2XotuXm/9Tt4iB5w10090	rigid:Xf0aWe9scLKe9+Hw6MUyMKOVvfk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CJG0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8VDJ3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8317711|intact:MINT-1858511|ensembl:ENSMUSP00000043047|ensembl:ENSMUSP00000127903	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:vigln_mouse(display_long)|uniprotkb:Hdlbp(gene name)|psi-mi:Hdlbp(display_short)|uniprotkb:High density lipoprotein-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001288293.1|refseq:NP_598569.1|refseq:XP_006529137.1|refseq:XP_006529138.1|refseq:XP_006529139.1|refseq:XP_006529140.1|ensembl:ENSMUSG00000034088(gene)|ensembl:ENSMUST00000042498(transcript)|ensembl:ENSMUST00000170883(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006869"(lipid transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0034364"(high-density lipoprotein particle)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q8VDJ3|reactome:R-MMU-8964011	-	-	function:Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol|comment:mint	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:H8VW/Tp0f9b24nwslsUWF+CW/xE10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q91XU0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8376575|intact:MINT-4113108|uniprotkb:Q921W3|uniprotkb:Q8BWP6|uniprotkb:Q3TCT7|uniprotkb:Q6PDF0|uniprotkb:Q9EQL3|uniprotkb:Q8BY55|uniprotkb:Q8BUW5|ensembl:ENSMUSP00000021832	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:wrip1_mouse(display_long)|uniprotkb:Wrnip1(gene name)|psi-mi:Wrnip1(display_short)|uniprotkb:Whip(gene name synonym)|uniprotkb:Werner helicase-interacting protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_084491.3|ensembl:ENSMUSG00000021400(gene)|ensembl:ENSMUST00000021832(transcript)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR021886|interpro:IPR027417|interpro:IPR032423|interpro:IPR040539|mint:Q91XU0	-	-	comment:mint|function:Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:3cjtBXbw7X8eJ6V9tsVNsTKXXjA10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8BP67	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-7914360|uniprotkb:P38663|uniprotkb:Q58EA4|intact:MINT-1857981|ensembl:ENSMUSP00000023269	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl24_mouse(display_long)|uniprotkb:Rpl24(gene name)|psi-mi:Rpl24(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_077180.1|ensembl:ENSMUSG00000098274(gene)|ensembl:ENSMUST00000023269(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0010458"(exit from mitosis)|go:"GO:0021554"(optic nerve development)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:1902626"(assembly of large subunit precursor of preribosome)|interpro:IPR000988(Ribosomal protein L24e)|interpro:IPR011017(TRASH)|interpro:IPR023442|interpro:IPR038630|mint:Q8BP67|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|reactome:R-MMU-6791226	-	-	comment:mint	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:+Ah+YGgcjqOsk5ZS1HZUMQA/Of810090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8K370	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8351209|uniprotkb:Q8K313|intact:MINT-1839952|uniprotkb:Q8BWQ0|ensembl:ENSMUSP00000031412|ensembl:ENSMUSP00000107400	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:acd10_mouse(display_long)|uniprotkb:Acad10(gene name)|psi-mi:Acad10(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_082313.2|refseq:XP_006530521.1|refseq:XP_006530523.1|refseq:XP_006530524.1|ensembl:ENSMUSG00000029456(gene)|ensembl:ENSMUST00000031412(transcript)|ensembl:ENSMUST00000111770(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0016787"(hydrolase activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002575(Aminoglycoside phosphotransferase)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR006439(HAD-superfamily hydrolase, subfamily IA, variant 1)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011945(Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR023198|interpro:IPR023214|interpro:IPR036250|interpro:IPR036412|interpro:IPR037069|interpro:IPR041492|interpro:IPR041726|mint:Q8K370|reactome:R-MMU-77289	-	-	comment:mint	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:IsgrBdnCIl/Afx8GNhD8OrVs9aU10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9Z108	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8020609|intact:UNK-5561237|ensembl:ENSMUSP00000104859	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:stau1_mouse(display_long)|uniprotkb:Stau1(gene name)|psi-mi:Stau1(display_short)|uniprotkb:Stau(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035620.1|ensembl:ENSMUSG00000039536(gene)|ensembl:ENSMUST00000109236(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008298"(intracellular mRNA localization)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030425"(dendrite)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099010"(modification of postsynaptic structure)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR044475|mint:Q9Z108	-	-	comment:mint|function:"Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site"	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:9zPJq1T9MxPD12EiZZWLuRcCpTk10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q61701	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8339146|uniprotkb:A2A9R6|uniprotkb:A2A9R8|uniprotkb:A2A9S0|uniprotkb:A2A9S1|uniprotkb:A2A9S2|uniprotkb:A2A9S3|uniprotkb:Q6PHZ3|uniprotkb:Q8BVA9|intact:MINT-4094262|uniprotkb:O55010|uniprotkb:A2A9R7|ensembl:ENSMUSP00000102207	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:elav4_mouse(display_long)|uniprotkb:Elavl4(gene name)|psi-mi:Elavl4(display_short)|uniprotkb:Hud(gene name synonym)|uniprotkb:Paraneoplastic encephalomyelitis antigen HuD(gene name synonym)|uniprotkb:Hu-antigen D(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001033787.1|refseq:NP_034618.2|refseq:NP_001334107.1|refseq:XP_006502862.1|ensembl:ENSMUSG00000028546(gene)|ensembl:ENSMUST00000106597(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006396"(RNA processing)|go:"GO:0006397"(mRNA processing)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008306"(associative learning)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031099"(regeneration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0097158"(pre-mRNA intronic pyrimidine-rich binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1905870"(positive regulation of 3'-UTR-mediated mRNA stabilization)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034918|interpro:IPR035979|mint:Q61701	-	-	function:May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR|comment:mint	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:HXthuBphfQOW5EWQAG1smb8ljZY10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P47964	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8365611|intact:MINT-4132614	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl36_mouse(display_long)|uniprotkb:Rpl36(gene name)|psi-mi:Rpl36(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR038097|mint:P47964|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0045202"(synapse)|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|interpro:IPR000509(Ribosomal protein L36e)	-	-	comment:mint	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:LNDybrXOVq0igi414xuHjWUY1gg10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9JKS5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8327279|intact:MINT-4130138|uniprotkb:Q3UNH8|uniprotkb:Q9D450	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:habp4_mouse(display_long)|uniprotkb:Habp4(gene name)|psi-mi:Habp4(display_short)|uniprotkb:Hyaluronic acid-binding protein 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR032381|interpro:IPR006861(Hyaluronan/mRNA binding protein)|refseq:NP_064370.2|mint:Q9JKS5|interpro:IPR039764|go:"GO:0003723"(RNA binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0015030"(Cajal body)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030017"(sarcomere)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030578"(PML body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097504"(Gemini of coiled bodies)|reactome:R-MMU-114608	-	-	comment:mint|function:May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:HOcw3XJjHRFlRAqmVFZhPa7mXeQ10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8BK67	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8357590|uniprotkb:A2AWQ3|uniprotkb:Q6ZPQ0|intact:MINT-4111085|ensembl:ENSMUSP00000038144|ensembl:ENSMUSP00000071163	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rcc2_mouse(display_long)|uniprotkb:Rcc2(gene name)|psi-mi:Rcc2(display_short)|uniprotkb:Kiaa1470(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_776292.1|refseq:XP_006538534.1|ensembl:ENSMUSG00000040945(gene)|ensembl:ENSMUST00000038893(transcript)|ensembl:ENSMUST00000071169(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034506"(chromosome, centromeric core domain)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051301"(cell division)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0072356"(chromosome passenger complex localization to kinetochore)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|mint:Q8BK67|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|interpro:IPR028641	-	-	comment:mint|function:Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:drUhR8O/tjyyyti5OLk0hM0VIW010090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8K1N4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8440204|uniprotkb:Q8C810|uniprotkb:Q3UX77|uniprotkb:Q8R1P6|intact:MINT-4117082|ensembl:ENSMUSP00000070549	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:spas2_mouse(display_long)|uniprotkb:Spats2(gene name)|psi-mi:Spats2(display_short)|uniprotkb:Scr59(gene name synonym)|uniprotkb:Serine-rich spermatocytes and round spermatid 59 kDa protein(gene name synonym)|uniprotkb:p59scr(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_011244039.1|refseq:NP_631879.1|ensembl:ENSMUSG00000051934(gene)|ensembl:ENSMUST00000063517(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR009060(UBA-like)|interpro:IPR009816(Protein of unknown function DUF1387)|mint:Q8K1N4	-	-	comment:mint	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:pHYbbujEidsiqFiPzHScEMINoTI10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q60900	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8322932|uniprotkb:Q60901|intact:MINT-4094236|ensembl:ENSMUSP00000003501	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:elav3_mouse(display_long)|uniprotkb:Elavl3(gene name)|psi-mi:Elavl3(display_short)|uniprotkb:Huc(gene name synonym)|uniprotkb:Hu-antigen C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_034617.1|refseq:XP_006510085.1|ensembl:ENSMUSG00000003410(gene)|ensembl:ENSMUST00000003501(transcript)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034915|interpro:IPR035979|mint:Q60900|rcsb pdb:1D8Z|rcsb pdb:1D9A|rcsb pdb:1FNX	-	-	function:May be involved in neuronal differentiation and maintenance|comment:mint	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:qUvIDm1H0L+uyA+cVP6Kjefc2N810090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q60899	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8329853|intact:MINT-4094224|ensembl:ENSMUSP00000008633	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:elav2_mouse(display_long)|uniprotkb:Elavl2(gene name)|psi-mi:Elavl2(display_short)|uniprotkb:Hub(gene name synonym)|uniprotkb:Hu-antigen B(gene name synonym)|uniprotkb:ELAV-like neuronal protein 1(gene name synonym)|uniprotkb:Nervous system-specific RNA-binding protein Mel-N1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_034616.1|refseq:XP_006502852.1|refseq:XP_006502853.1|refseq:XP_006502854.1|ensembl:ENSMUSG00000008489(gene)|ensembl:ENSMUST00000008633(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0045202"(synapse)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034914|interpro:IPR034999|interpro:IPR035979|mint:Q60899|reactome:R-MMU-72163	-	-	comment:mint|function:Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:dgDCiu1mN8mz6K95+ihBGQY8K8k10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9DBY8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8339942|uniprotkb:Q8BW27|uniprotkb:Q3USC4|intact:MINT-4104517|uniprotkb:Q8K2B5|ensembl:ENSMUSP00000027797	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nvl_mouse(display_long)|uniprotkb:Nvl(gene name)|psi-mi:Nvl(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080447.1|ensembl:ENSMUSG00000026516(gene)|ensembl:ENSMUST00000027797(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:1904749"(regulation of protein localization to nucleolus)|go:"GO:1990275"(preribosome binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|interpro:IPR031996|interpro:IPR038100|interpro:IPR041569|mint:Q9DBY8|rcsb pdb:2RRE	-	-	comment:mint	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:fUPan5RrtNtqdP9FfB3ywQVbKZQ10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q91W18	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8329718|uniprotkb:Q8C1A4|uniprotkb:Q8BZW6|intact:UNK-5479555|intact:MINT-4137349|uniprotkb:E9Q2Q4|intact:UNK-5512156|uniprotkb:Q6NZG7|ensembl:ENSMUSP00000129019	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tdrd3_mouse(display_long)|uniprotkb:Tdrd3(gene name)|psi-mi:Tdrd3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001240684.1|refseq:NP_766193.3|ensembl:ENSMUSG00000022019(gene)|ensembl:ENSMUST00000168275(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006397"(mRNA processing)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035145"(exon-exon junction complex)|interpro:IPR002999(Tudor)|interpro:IPR009060(UBA-like)|interpro:IPR010304(Survival motor neuron)|interpro:IPR013894(Region of unknown function DUF1767)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR033472|interpro:IPR041915|interpro:IPR042470|mint:Q91W18|rcsb pdb:2D9T	-	-	comment:mint	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:OJkc6E7+tTHuVr5BSCn8MtiApZk10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q61315	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-7848277|uniprotkb:Q62044|intact:UNK-5461725	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:apc_mouse(display_long)|uniprotkb:Apc(gene name)|psi-mi:Apc(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0001822"(kidney development)|go:"GO:0001942"(hair follicle development)|go:"GO:0002020"(protease binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009798"(axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042483"(negative regulation of odontogenesis)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043588"(skin development)|go:"GO:0044295"(axonal growth cone)|go:"GO:0031253"(cell projection membrane)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044337"(canonical Wnt signaling pathway involved in positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051171"(regulation of nitrogen compound metabolic process)|go:"GO:0051276"(chromosome organization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070852"(cell body fiber)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000211"(regulation of glutamate metabolic process)|rcsb pdb:1VJ6|reactome:R-MMU-111465|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-3769402|reactome:R-MMU-4641262|reactome:R-MMU-5689896|interpro:IPR032038|mint:Q61315|interpro:IPR009224(SAMP)|interpro:IPR000225(Armadillo)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009232(EB-1 binding)|interpro:IPR026818|interpro:IPR011989(Armadillo-like helical)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR026836|interpro:IPR036149|interpro:IPR041257	-	-	function:Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. APC activity is correlated with its phosphorylation state|comment:mint	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:5LB5NjRyV0VFe8xzCkg3/o+44g410090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O09167	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-7977824|intact:MINT-1858045	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl21_mouse(display_long)|uniprotkb:Rpl21(gene name)|psi-mi:Rpl21(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR008991(Translation protein SH3-like)|interpro:IPR018259|interpro:IPR036948|mint:O09167|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|interpro:IPR001147(Ribosomal protein L21e)	-	-	comment:mint	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:uEJx6Wv/rFvNeu2dalcIkOKkyxo10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6A0A9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8327719|intact:MINT-1858841|uniprotkb:Q91Z16|uniprotkb:B3DFJ0|uniprotkb:A0PJK6|ensembl:ENSMUSP00000053877	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:f120a_mouse(display_long)|uniprotkb:Kiaa0183(gene name synonym)|uniprotkb:Ossa(gene name synonym)|uniprotkb:Oxidative stress-associated Src activator(gene name synonym)|uniprotkb:Protein FAM120A(gene name synonym)|uniprotkb:FAM120A(gene name)|psi-mi:FAM120A(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001028440.2|ensembl:ENSMUSG00000038014(gene)|ensembl:ENSMUST00000060805(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR026784|interpro:IPR029060|mint:Q6A0A9	-	-	comment:"fragmentation type: fragment"|comment:mint	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:tZj0TOhfuvvF4GaEPHI7jWpKyl810090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6PGC1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8428992|uniprotkb:Q8C9H9|uniprotkb:Q8C9B7|intact:MINT-4112300|uniprotkb:Q8BQJ4|uniprotkb:Q8BT01|ensembl:ENSMUSP00000035244	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dhx29_mouse(display_long)|uniprotkb:Dhx29(gene name)|psi-mi:Dhx29(display_short)|uniprotkb:DEAH box protein 29(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_766182.2|ensembl:ENSMUSG00000042426(gene)|ensembl:ENSMUST00000038574(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0008494"(translation activator activity)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042255"(ribosome assembly)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR034730|mint:Q6PGC1	-	-	comment:mint	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:rORkrwC6jPYK8bp9O+7RaI5e9KI10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P52479	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8327299|uniprotkb:Q6ZQG9|uniprotkb:Q91VY7|uniprotkb:Q3TZB8|intact:MINT-1870263|uniprotkb:Q3U5E0|uniprotkb:Q3T9L4|uniprotkb:Q3TNN5|ensembl:ENSMUSP00000104616	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ubp10_mouse(display_long)|uniprotkb:Usp10(gene name)|psi-mi:Usp10(display_short)|uniprotkb:Ode-1(gene name synonym)|uniprotkb:Uchrp(gene name synonym)|uniprotkb:Kiaa0190(gene name synonym)|uniprotkb:Ubiquitin thioesterase 10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 10(gene name synonym)|uniprotkb:Deubiquitinating enzyme 10(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001297559.1|refseq:NP_033488.1|ensembl:ENSMUSG00000031826(gene)|ensembl:ENSMUST00000108988(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR018200|interpro:IPR028767|interpro:IPR028889|interpro:IPR038765|mint:P52479|reactome:R-MMU-5656169|reactome:R-MMU-5689880	-	-	comment:mint|function:Ubiquitin specific protease are required to remove ubiquitin from specific proteins or peptides to which ubiquitin is attached	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:tdoxBRcosuC3GGqMGB5pBKA9pKc10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q61584	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	-	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99J85	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8311244|intact:MINT-4104086	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nptxr_mouse(display_long)|uniprotkb:Nptxr(gene name)|psi-mi:Nptxr(display_short)|uniprotkb:Npr(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0008029"(pentraxin receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099150"(regulation of postsynaptic specialization assembly)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR030476|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|mint:Q99J85	-	-	comment:mint	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:AWabDfkkTcL+AMgJlRt5ntbJ5WU10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:B2RR83	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8572369|ensembl:ENSMUSP00000048340|intact:MINT-8174232	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ytdc2_mouse(display_long)|uniprotkb:Keen to exit meiosis leaving testes under-populated protein(gene name synonym)|uniprotkb:YTH domain-containing protein C2(gene name synonym)|uniprotkb:Ythdc2(gene name)|psi-mi:Ythdc2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR007275(YT521-B-like protein)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031083|interpro:IPR034083|interpro:IPR036770|interpro:IPR036867|mint:B2RR83|ensembl:ENSMUSG00000034653(gene)|ensembl:ENSMUST00000037763(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007286"(spermatid development)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048599"(oocyte development)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR001374(Single-stranded nucleic acid binding R3H)|refseq:NP_001156485.1	-	-	comment:mint	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:TxNENB71AFsznI6fFqBPUX8pgdA10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80U23	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8334059|uniprotkb:A2AT08|uniprotkb:A2AT09|uniprotkb:A2AT11|uniprotkb:A4FUV3|uniprotkb:A4VCI7|uniprotkb:Q4VA51|uniprotkb:Q8C8B8|uniprotkb:A2AT10|intact:MINT-4114767|uniprotkb:Q6GQX4|ensembl:ENSMUSP00000092026	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:snph_mouse(display_long)|uniprotkb:Snph(gene name)|psi-mi:Snph(display_short)|uniprotkb:Kiaa0374(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_011237840.1|refseq:NP_937857.1|refseq:NP_001278005.1|refseq:NP_001278006.1|ensembl:ENSMUSG00000027457(gene)|ensembl:ENSMUST00000094456(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045806"(negative regulation of endocytosis)|interpro:IPR026196|interpro:IPR028197|mint:Q80U23	-	-	function:Inhibits SNARE complex formation by absorbing free syntaxin-1|comment:mint	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:koJOoOh2nblMekK07E7dg+8csqg10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q91WM1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8339684|intact:MINT-4121401|uniprotkb:Q62262|ensembl:ENSMUSP00000028279|ensembl:ENSMUSP00000072047	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:strbp_mouse(display_long)|uniprotkb:Strbp(gene name)|psi-mi:Strbp(display_short)|uniprotkb:Spnr(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_011237348.1|refseq:XP_011237349.1|refseq:NP_033287.2|refseq:XP_017172309.1|refseq:XP_017172310.1|refseq:XP_017172311.1|refseq:XP_017172312.1|ensembl:ENSMUSG00000026915(gene)|ensembl:ENSMUST00000028279(transcript)|ensembl:ENSMUST00000072186(transcript)|go:"GO:0002177"(manchette)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0007638"(mechanosensory behavior)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR030446|interpro:IPR043519|interpro:IPR044472|mint:Q91WM1	-	-	comment:mint|function:"Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth (By similarity). Binds to double-stranded DNA and RNA (By similarity). Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA (By similarity). Binds also to single-stranded poly(G) RNA (By similarity). Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA"	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:+sf/OyoCMvzDmHmCmq4Me4jWjco10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9WTT4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6273387|ensembl:ENSMUSP00000069482	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:vatg2_mouse(display_long)|uniprotkb:Atp6v1g2(gene name)|psi-mi:Atp6v1g2(display_short)|uniprotkb:Atp6g2(gene name synonym)|uniprotkb:Ng38(gene name synonym)|uniprotkb:V-ATPase 13 kDa subunit 2(gene name synonym)|uniprotkb:Vacuolar proton pump subunit G 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000024403(gene)|ensembl:ENSMUST00000068261(transcript)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0042470"(melanosome)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|interpro:IPR005124("Vacuolar (H+)-ATPase G subunit")|mint:Q9WTT4|reactome:R-MMU-1222556|reactome:R-MMU-77387|reactome:R-MMU-917977|reactome:R-MMU-9639288|reactome:R-MMU-983712|refseq:NP_001334280.1|refseq:NP_075668.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:IGtYI45kRT49q4bPMtZMCJowYKs10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80WG5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-20718010|ensembl:ENSMUSP00000092690|ensembl:ENSMUSP00000109284|ensembl:ENSMUSP00000139038|uniprotkb:A2AQZ0	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:lrc8a_mouse(display_long)|uniprotkb:Protein ebouriffe(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 8A(gene name synonym)|uniprotkb:Lrrc8a(gene name)|psi-mi:Lrrc8a(display_short)|uniprotkb:Lrrc8(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000099041(gene)|ensembl:ENSMUST00000095078(transcript)|ensembl:ENSMUST00000113654(transcript)|ensembl:ENSMUST00000139454(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002329"(pre-B cell differentiation)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0015734"(taurine transport)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034702"(ion channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0098656"(anion transmembrane transport)|go:"GO:0140360"(cyclic-GMP-AMP transmembrane transporter activity)|go:"GO:0140361"(cyclic-GMP-AMP transmembrane import across plasma membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|ensembl:ENSMUSG00000007476(gene)|interpro:IPR021040|interpro:IPR032675|mint:Q80WG5|rcsb pdb:6FNW|rcsb pdb:6G8Z|rcsb pdb:6G9L|rcsb pdb:6G9O|rcsb pdb:6NZW|rcsb pdb:6NZZ|rcsb pdb:6O00|rcsb pdb:7M17|rcsb pdb:7M19|reactome:R-MMU-5223345|refseq:NP_808393.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:a39hFvsEXuauN4cwEgT+rKHU3oo10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6P5D3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471284|ensembl:ENSMUSP00000083742|uniprotkb:Q3TS93|uniprotkb:Q6NZK4|uniprotkb:Q6P1B4|uniprotkb:Q8BI63|uniprotkb:Q8BIA2|uniprotkb:Q8R360	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dhx57_mouse(display_long)|uniprotkb:Dhx57(gene name)|psi-mi:Dhx57(display_short)|uniprotkb:DEAH box protein 57(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000035051(gene)|ensembl:ENSMUST00000086555(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006575(RWD)|interpro:IPR007502(Helicase-associated region)|interpro:IPR009060(UBA-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR027417|interpro:IPR036855|interpro:IPR042615|mint:Q6P5D3|refseq:NP_001157231.1|refseq:NP_945180.2|refseq:XP_006523510.1|refseq:XP_006523511.1|refseq:XP_017172691.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:nAZbsulRL3ILa8GPejiItndIZts10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9JJY4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-944496|uniprotkb:Q059Z6|uniprotkb:Q9JIK4|ensembl:ENSMUSP00000088176	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ddx20_mouse(display_long)|uniprotkb:Ddx20(gene name)|psi-mi:Ddx20(display_short)|uniprotkb:Dp103(gene name synonym)|uniprotkb:Gemin3(gene name synonym)|uniprotkb:DEAD box protein 20(gene name synonym)|uniprotkb:DEAD box protein DP 103(gene name synonym)|uniprotkb:Component of gems 3(gene name synonym)|uniprotkb:Gemin-3(gene name synonym)|uniprotkb:Regulator of steroidogenic factor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_059093.3|refseq:XP_006501764.1|ensembl:ENSMUSG00000027905(gene)|ensembl:ENSMUST00000090680(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032797"(SMN complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048477"(oogenesis)|go:"GO:0050810"(regulation of steroid biosynthetic process)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0097504"(Gemini of coiled bodies)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q9JJY4|reactome:R-MMU-191859	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:qoEKTrnCV+OBWfbeNBdVTUHAArU10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P70398	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2214043|uniprotkb:E9QLY0|uniprotkb:Q62497	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:usp9x_mouse(display_long)|uniprotkb:Ubiquitin thioesterase FAF-X(gene name synonym)|uniprotkb:Usp9x(gene name)|psi-mi:Usp9x(display_short)|uniprotkb:Fafl(gene name synonym)|uniprotkb:Fam(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease FAF-X(gene name synonym)|uniprotkb:Deubiquitinating enzyme FAF-X(gene name synonym)|uniprotkb:Fat facets protein-related, X-linked(gene name synonym)|uniprotkb:Ubiquitin-specific protease 9, X chromosome(gene name synonym)|uniprotkb:Ubiquitin carboxyl-terminal hydrolase FAM(gene name synonym)|uniprotkb:Fat facets homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR016024(Armadillo-type fold)|interpro:IPR028889|refseq:NP_033507.2|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:P70398|interpro:IPR038765|interpro:IPR021905|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021698"(cerebellar cortex structural organization)|go:"GO:0021766"(hippocampus development)|go:"GO:0030426"(growth cone)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045177"(apical part of cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|reactome:R-MMU-2173795|reactome:R-MMU-5689880|reactome:R-MMU-8866652|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-9033241	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:QXx5gkd+PxoNgIj2b2dLjpCuNr410090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CJF9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-9030886|uniprotkb:Q3TBP7|ensembl:ENSMUSP00000066633	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ago3_mouse(display_long)|uniprotkb:Ago3(gene name)|psi-mi:Ago3(display_short)|uniprotkb:Eif2c3(gene name synonym)|uniprotkb:Argonaute RISC catalytic component 3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 3(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_700451.2|ensembl:ENSMUSG00000028842(gene)|ensembl:ENSMUST00000069097(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0046872"(metal ion binding)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028603|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJF9|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:JBJer7uFfQamp+D9D7xPSd0iPuo10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:D3YXK2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-539539|ensembl:ENSMUSP00000092849	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:safb1_mouse(display_long)|uniprotkb:Safb(gene name)|psi-mi:Safb(display_short)|uniprotkb:Safb1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001156772.1|ensembl:ENSMUST00000095224(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030496"(midbody)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0040008"(regulation of growth)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050684"(regulation of mRNA processing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034781|interpro:IPR035979|interpro:IPR036361|mint:D3YXK2|ensembl:ENSMUSG00000071054(gene)|reactome:R-MMU-3899300	-	-	comment:Author screened murine library then identified protein by homology to rat. Currently no murine sequence in database.	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:wGs3hvKUEDoWR83eBl9+qv4JWzs10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80XU3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-5295659|uniprotkb:Q8BVD8|ensembl:ENSMUSP00000062576	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nucks_mouse(display_long)|uniprotkb:Nucks1(gene name)|psi-mi:Nucks1(display_short)|uniprotkb:Nucks(gene name synonym)|uniprotkb:JC7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001139276.1|refseq:NP_780503.2|ensembl:ENSMUSG00000026434(gene)|ensembl:ENSMUST00000062264(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006325"(chromatin organization)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0019046"(release from viral latency)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0060382"(regulation of DNA strand elongation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990968"(modulation by host of RNA binding by virus)|go:"GO:1990969"(modulation by host of viral RNA-binding transcription factor activity)|interpro:IPR026633|mint:Q80XU3	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:kizDkHbqLwthuDMp8w1hNyLorFw10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CQJ6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472008|ensembl:ENSMUSP00000023869|uniprotkb:Q3UXY1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:denr_mouse(display_long)|uniprotkb:Denr(gene name)|psi-mi:Denr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000023106(gene)|ensembl:ENSMUST00000023869(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR001950(Translation initiation factor SUI1)|interpro:IPR005873(Density-regulated protein DRP1)|interpro:IPR036877|mint:Q9CQJ6|refseq:NP_080879.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Ng4Exx8ebd9KHHd3492HziiDlIo10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q61550	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2550110|uniprotkb:Q3TQ09|uniprotkb:Q810A8|ensembl:ENSMUSP00000022927|uniprotkb:P70219|uniprotkb:Q91VB9|uniprotkb:Q9DBU4	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rad21_mouse(display_long)|uniprotkb:Rad21(gene name)|psi-mi:Rad21(display_short)|uniprotkb:Hr21(gene name synonym)|uniprotkb:Pokeweed agglutinin-binding protein 29(gene name synonym)|uniprotkb:SCC1 homolog(gene name synonym)|uniprotkb:Scc1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0008278"(cohesin complex)|go:"GO:0010972"(negative regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016363"(nuclear matrix)|go:"GO:0034990"(nuclear mitotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0045841"(negative regulation of mitotic metaphase/anaphase transition)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|interpro:IPR006909(Rad21/Rec8 like protein, C-terminal)|interpro:IPR006910(Rad21/Rec8 like protein, N-terminal)|interpro:IPR023093|interpro:IPR036390|interpro:IPR039781|mint:Q61550|reactome:R-MMU-2467813|reactome:R-MMU-2468052|go:"GO:0003682"(chromatin binding)|reactome:R-MMU-2470946|reactome:R-MMU-2500257|reactome:R-MMU-3108214|ensembl:ENSMUSG00000022314(gene)|ensembl:ENSMUST00000022927(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000795"(synaptonemal complex)|refseq:NP_033035.3|refseq:XP_006520707.1|refseq:XP_006520708.1|dip:DIP-56655N	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:TXbWgmegqmBbcsQxxC4t7A/nc3o10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O70589	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-771402|uniprotkb:A2ADP8|uniprotkb:A2ADP9|uniprotkb:A2ADQ4|uniprotkb:O70588|uniprotkb:Q3UW92	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cskp_mouse(display_long)|uniprotkb:Calcium/calmodulin-dependent serine protein kinase(gene name synonym)|uniprotkb:Cask(gene name)|psi-mi:Cask(display_short)|uniprotkb:Lin-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001271432.1|refseq:NP_001271433.1|refseq:NP_001271434.1|refseq:NP_033936.2|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR011009(Protein kinase-like)|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:O70589|go:"GO:0060170"(ciliary membrane)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070509"(calcium ion import)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097440"(apical dendrite)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098846"(podocyte foot)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|rcsb pdb:1Y74|rcsb pdb:6Y9O|reactome:R-MMU-212676|reactome:R-MMU-6794361|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031982"(vesicle)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:3co6JdI4q/n5C8zGb5JYFL2t7pc10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3LAC4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471859|ensembl:ENSMUSP00000027056|uniprotkb:E9QMG3|uniprotkb:Q3UQI2|uniprotkb:Q3UU18|uniprotkb:Q9CXD5	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:prex2_mouse(display_long)|uniprotkb:Prex2(gene name)|psi-mi:Prex2(display_short)|uniprotkb:Depdc2(gene name synonym)|uniprotkb:DEP domain-containing protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000048960(gene)|ensembl:ENSMUST00000027056(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0048813"(dendrite morphogenesis)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR037367|mint:Q3LAC4|reactome:R-MMU-8948751|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|refseq:NP_083801.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:WFnLEKIfvbYlUiklWxhr1Mw11ZA10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80U28	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6271803|uniprotkb:Q3TQK3|uniprotkb:Q6P4I6|uniprotkb:Q80W52|uniprotkb:Q80WL3|uniprotkb:Q80WL4|uniprotkb:Q80WL5|uniprotkb:Q80WL6|uniprotkb:Q80WL7|uniprotkb:Q80WL8|uniprotkb:Q80WL9|uniprotkb:Q80WM0|uniprotkb:Q80WM1|uniprotkb:Q80WM2|uniprotkb:Q8CBC1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:madd_mouse(display_long)|uniprotkb:Rab3 GDP/GTP exchange protein(gene name synonym)|uniprotkb:Madd(gene name)|psi-mi:Madd(display_short)|uniprotkb:Kiaa0358(gene name synonym)|uniprotkb:Rab3 GDP/GTP exchange factor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR037516|mint:Q80U28|refseq:NP_001171190.1|refseq:NP_001171191.1|refseq:NP_663502.3|interpro:IPR005112(dDENN)|interpro:IPR001194(DENN)|interpro:IPR005113(uDENN)|refseq:XP_017173117.1|interpro:IPR039980|interpro:IPR043153|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0032483"(regulation of Rab protein signal transduction)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1902041"(regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902277"(negative regulation of pancreatic amylase secretion)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|reactome:R-MMU-5357905|reactome:R-MMU-8876198|go:"GO:0016021"(integral component of membrane)	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:N1jHLTmvUiVv+sCMbX8Q/nAq7XI10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9D6G9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470970|ensembl:ENSMUSP00000036138|uniprotkb:Q9DB66	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cklf5_mouse(display_long)|uniprotkb:Cmtm5(gene name)|psi-mi:Cmtm5(display_short)|uniprotkb:Cklfsf5(gene name synonym)|uniprotkb:Chemokine-like factor superfamily member 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000040759(gene)|ensembl:ENSMUST00000037814(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045662"(negative regulation of myoblast differentiation)|interpro:IPR008253(Marvel)|mint:Q9D6G9|refseq:NP_080342.1|refseq:XP_017171651.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Kj8DRGtMwsoKRnanvRkfzDr+4J810090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TPV4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-1373622|uniprotkb:O35851|uniprotkb:Q80Y66|uniprotkb:Q8R4X2|uniprotkb:Q99KP0|ensembl:ENSMUSP00000044827	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mbb1a_mouse(display_long)|uniprotkb:Mybbp1a(gene name)|psi-mi:Mybbp1a(display_short)|uniprotkb:P160(gene name synonym)|uniprotkb:Myb-binding protein of 160 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_058056.2|dip:DIP-39831N|ensembl:ENSMUSG00000040463(gene)|ensembl:ENSMUST00000045633(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070888"(E-box binding)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR007015(DNA polymerase V)|interpro:IPR016024(Armadillo-type fold)|mint:Q7TPV4|reactome:R-MMU-5250924	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:rt1TQLZB7JNBkpt3DooDAlzOYCo10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99J31	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-12517589|ensembl:ENSMUSP00000033560|ensembl:ENSMUSP00000109457|uniprotkb:Q544K7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ophn1_mouse(display_long)|uniprotkb:Ophn1(gene name)|psi-mi:Ophn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000031214(gene)|ensembl:ENSMUST00000033560(transcript)|ensembl:ENSMUST00000113826(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0034329"(cell junction assembly)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|interpro:IPR000198(RhoGAP)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q99J31|reactome:R-MMU-9013406|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013423|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|refseq:NP_001300683.1|refseq:NP_001300684.1|refseq:NP_001300685.1|refseq:NP_443208.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:xgvDj9c8xw1/D2QQyFY4/ywYlZw10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P59644	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472972|ensembl:ENSMUSP00000046625|uniprotkb:Q3TDM9	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:pi5pa_mouse(display_long)|uniprotkb:Inpp5j(gene name)|psi-mi:Inpp5j(display_short)|uniprotkb:Pib5pa(gene name synonym)|uniprotkb:Inositol polyphosphate 5-phosphatase J(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000034570(gene)|ensembl:ENSMUST00000044507(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR041611|mint:P59644|reactome:R-MMU-1660499|reactome:R-MMU-1855183|reactome:R-MMU-1855204|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|refseq:NP_766027.2	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:CkCMJcgIIslEYGnSK82TfllYIgs10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P62900	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2527089|uniprotkb:P12947|ensembl:ENSMUSP00000083722|ensembl:ENSMUSP00000136354|ensembl:ENSMUSP00000137631	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl31_mouse(display_long)|uniprotkb:Rpl31(gene name)|psi-mi:Rpl31(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000073702(gene)|ensembl:ENSMUST00000086535(transcript)|ensembl:ENSMUST00000178079(transcript)|ensembl:ENSMUST00000179954(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|interpro:IPR000054(Ribosomal protein L31e)|interpro:IPR020052|interpro:IPR023621|mint:P62900|rcsb pdb:6SWA|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|reactome:R-MMU-156827|refseq:NP_444487.1|refseq:NP_001239147.1|refseq:NP_001239148.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:77LFR7/2somk6blVogZf1XFdJLk10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P33173	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2013334|uniprotkb:Q61770	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kif1a_mouse(display_long)|uniprotkb:Kif1a(gene name)|psi-mi:Kif1a(display_short)|uniprotkb:Atsv(gene name synonym)|uniprotkb:Kif1(gene name synonym)|uniprotkb:Axonal transporter of synaptic vesicles(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	mint:P33173|dip:DIP-46956N|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0098674"(extrinsic component of neuronal dense core vesicle membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:0099519"(dense core granule cytoskeletal transport)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990048"(anterograde neuronal dense core vesicle transport)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019821|interpro:IPR022140|interpro:IPR022164|interpro:IPR027417|interpro:IPR027640|interpro:IPR032405|interpro:IPR036961|rcsb pdb:1I5S|rcsb pdb:1I6I|rcsb pdb:1IA0|rcsb pdb:1VFV|rcsb pdb:1VFW|rcsb pdb:1VFX|rcsb pdb:1VFZ|rcsb pdb:2HXF|rcsb pdb:2HXH|rcsb pdb:2ZFI|rcsb pdb:2ZFJ|rcsb pdb:2ZFK|rcsb pdb:2ZFL|rcsb pdb:2ZFM|reactome:R-MMU-2132295|reactome:R-MMU-6811434|reactome:R-MMU-983189	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:TPA+Boj3ol4jv+aZcFpgA4eEblA10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CCP0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-21287768|ensembl:ENSMUSP00000021368|uniprotkb:Q9CW30|uniprotkb:Q3TAS9|uniprotkb:Q3UF46|uniprotkb:Q66JX6|uniprotkb:Q8C9R6|uniprotkb:Q8CA65|uniprotkb:Q8JZT9|uniprotkb:Q8R072|uniprotkb:Q9CYB8|uniprotkb:Q9D4A9	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nemf_mouse(display_long)|uniprotkb:Nemf(gene name)|psi-mi:Nemf(display_short)|uniprotkb:Sdccag1(gene name synonym)|uniprotkb:Serologically defined colon cancer antigen 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR008532(Protein of unknown function DUF814)|interpro:IPR021846|mint:Q8CCP0|ensembl:ENSMUSG00000020982(gene)|ensembl:ENSMUST00000021368(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0051168"(nuclear export)|go:"GO:0072344"(rescue of stalled ribosome)|go:"GO:1990112"(RQC complex)|refseq:NP_079717.2	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:bG5XjTFtIiLOkxsOodoR69nYkcU10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8BHL3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472950|ensembl:ENSMUSP00000113307|uniprotkb:Q6GQW9|uniprotkb:Q6PIZ5|uniprotkb:Q91XR3	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tb10b_mouse(display_long)|uniprotkb:Tbc1d10b(gene name)|psi-mi:Tbc1d10b(display_short)|uniprotkb:Protein wz3-85(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000042492(gene)|ensembl:ENSMUST00000120705(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR035969|mint:Q8BHL3|reactome:R-MMU-8854214|refseq:NP_653105.3	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:2H3lfaMqWZeTEq6xjmrOJus3XnA10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8BXJ8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472924|ensembl:ENSMUSP00000107462|ensembl:ENSMUSP00000088271|uniprotkb:Q8BWQ7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:z385b_mouse(display_long)|uniprotkb:Znf385b(gene name)|psi-mi:Znf385b(display_short)|uniprotkb:Zfp385b(gene name synonym)|uniprotkb:Zfp533(gene name synonym)|uniprotkb:Znf533(gene name synonym)|uniprotkb:Zinc finger protein 533(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000090766(transcript)|ensembl:ENSMUST00000111831(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q8BXJ8|ensembl:ENSMUSG00000027016(gene)|refseq:NP_001106870.1|refseq:NP_001106871.1|refseq:NP_848838.2	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:3S0ofn39ep5mdFyf/lfOlFYCzmA10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P62751	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-4286547|uniprotkb:P29316|uniprotkb:P39024|uniprotkb:Q92774|ensembl:ENSMUSP00000099541	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl23a_mouse(display_long)|uniprotkb:Rpl23a(gene name)|psi-mi:Rpl23a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_997406.1|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:1904841"(TORC2 complex binding)|interpro:IPR001014(Ribosomal protein L23, conserved site)|interpro:IPR005633(Ribosomal protein L23/L25, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR013025(Ribosomal protein L25/L23)|interpro:IPR019985|mint:P62751|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|ensembl:ENSMUSG00000058546(gene)|ensembl:ENSMUST00000102483(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|dip:DIP-59973N	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:lA1ubRFO9/Tl54Z1dKUzoCKvpAo10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80UG5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-772170|uniprotkb:Q3URP2|uniprotkb:Q80TM7|uniprotkb:Q9QYX9|uniprotkb:A2A6U2|uniprotkb:A2A6U6|uniprotkb:A2A6U4|ensembl:ENSMUSP00000091435	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:sept9_mouse(display_long)|uniprotkb:Septin9(gene name)|psi-mi:Septin9(display_short)|uniprotkb:Kiaa0991(gene name synonym)|uniprotkb:SL3-3 integration site 1 protein(gene name synonym)|uniprotkb:Sept9(gene name synonym)|uniprotkb:Sint1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001106958.1|refseq:NP_001106959.1|refseq:NP_001106960.1|refseq:NP_059076.1|refseq:XP_006533808.2|refseq:XP_006533809.1|ensembl:ENSMUSG00000059248(gene)|ensembl:ENSMUST00000093907(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0005940"(septin ring)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0034613"(cellular protein localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0097730"(non-motile cilium)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|interpro:IPR030645|mint:Q80UG5	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:wWFo562fXoOMqUwD1l0xTM5aPlw10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6A068	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2552123|ensembl:ENSMUSP00000024727|uniprotkb:Q8K1J9	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cdc5l_mouse(display_long)|uniprotkb:Cdc5l(gene name)|psi-mi:Cdc5l(display_short)|uniprotkb:Kiaa0432(gene name synonym)|uniprotkb:Cdc5-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000023932(gene)|ensembl:ENSMUST00000024727(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|refseq:NP_690023.1|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:1904568"(cellular response to wortmannin)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017930|interpro:IPR021786|mint:Q6A068|reactome:R-MMU-72163|go:"GO:0005737"(cytoplasm)	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ehcu1kQlVD4/J1K3a77EcsjqRbI10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O70340	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472905|ensembl:ENSMUSP00000071687	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nptx2_mouse(display_long)|uniprotkb:Nptx2(gene name)|psi-mi:Nptx2(display_short)|uniprotkb:Neuronal pentraxin II(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000059991(gene)|ensembl:ENSMUST00000071782(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0008306"(associative learning)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|mint:O70340|refseq:NP_058069.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:iFE2+JkyEEWsx5b4I1p7HXEM+nc10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CQE8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-912160|ensembl:ENSMUSP00000022341	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rtraf_mouse(display_long)|uniprotkb:RTRAF(gene name)|psi-mi:RTRAF(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080804.1|ensembl:ENSMUSG00000021807(gene)|ensembl:ENSMUST00000022341(transcript)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:0072686"(mitotic spindle)|interpro:IPR019265|mint:Q9CQE8	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:AP73IJnWMs4jwKTGnIC+q1GcBRc10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P11881	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-541478|uniprotkb:P20943|uniprotkb:Q99LG5|ensembl:ENSMUSP00000032192	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:itpr1_mouse(display_long)|uniprotkb:Type 1 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 1(gene name synonym)|uniprotkb:Inositol 1,4,5-trisphosphate-binding protein P400(gene name synonym)|uniprotkb:Purkinje cell protein 1(gene name synonym)|uniprotkb:Protein PCD-6(gene name synonym)|uniprotkb:Itpr1(gene name)|psi-mi:Itpr1(display_short)|uniprotkb:Insp3r(gene name synonym)|uniprotkb:Pcd6(gene name synonym)|uniprotkb:Pcp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_034715.3|refseq:XP_006505693.1|refseq:XP_006505699.1|refseq:XP_006505700.1|dip:DIP-32243N|refseq:XP_017176897.1|refseq:XP_017176899.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0098794"(postsynapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|mint:P11881|rcsb pdb:1N4K|rcsb pdb:1XZZ|rcsb pdb:5GUG|rcsb pdb:5X9Z|rcsb pdb:5XA0|rcsb pdb:5XA1|reactome:R-MMU-114508|reactome:R-MMU-139853|reactome:R-MMU-381676|reactome:R-MMU-418457|reactome:R-MMU-5578775|reactome:R-MMU-983695|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097421"(liver regeneration)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098695"(inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels)|go:"GO:0098793"(presynapse)|ensembl:ENSMUSG00000030102(gene)|ensembl:ENSMUST00000032192(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:O+LA4/Acwos+RNtyqL3IgAe/kkk10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9D1M0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-4285415|uniprotkb:Q99M12|uniprotkb:Q9D712|ensembl:ENSMUSP00000032440	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:sec13_mouse(display_long)|uniprotkb:Sec13(gene name)|psi-mi:Sec13(display_short)|uniprotkb:Sec13l1(gene name synonym)|uniprotkb:SEC13-like protein 1(gene name synonym)|uniprotkb:SEC13-related protein(gene name synonym)|uniprotkb:GATOR complex protein SEC13(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_077168.2|ensembl:ENSMUSG00000030298(gene)|ensembl:ENSMUST00000032440(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032527"(protein exit from endoplasmic reticulum)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051028"(mRNA transport)|go:"GO:0061700"(GATOR2 complex)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:0090114"(COPII-coated vesicle budding)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR037363|interpro:IPR037596|mint:Q9D1M0|reactome:R-MMU-141444|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-170822|reactome:R-MMU-191859|reactome:R-MMU-204005|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3108214|reactome:R-MMU-3232142|reactome:R-MMU-3301854|reactome:R-MMU-3371453|reactome:R-MMU-4085377|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-5578749|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9615933|reactome:R-MMU-9639288|reactome:R-MMU-9648025|reactome:R-MMU-983170|interpro:IPR036322	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:40KHYuvc/jVIxhLJTKivv2NRm7I10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9JHU9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-1634601|ensembl:ENSMUSP00000019283|ensembl:ENSMUSP00000148077	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ino1_mouse(display_long)|uniprotkb:Isyna1(gene name)|psi-mi:Isyna1(display_short)|uniprotkb:Ino1(gene name synonym)|uniprotkb:Myo-inositol 1-phosphate synthase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_076116.1|ensembl:ENSMUSG00000019139(gene)|ensembl:ENSMUST00000019283(transcript)|ensembl:ENSMUST00000210005(transcript)|go:"GO:0004512"(inositol-3-phosphate synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006021"(inositol biosynthetic process)|go:"GO:0008654"(phospholipid biosynthetic process)|interpro:IPR002587(Myo-inositol-1-phosphate synthase)|interpro:IPR013021(Myo-inositol-1-phosphate synthase, GAPDH-like)|interpro:IPR036291|mint:Q9JHU9|reactome:R-MMU-1855183	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:2sC3BHRnI9YSxfIHmbuI27e0TJU10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80X66	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471043|ensembl:ENSMUSP00000048530	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:btbda_mouse(display_long)|uniprotkb:Btbd10(gene name)|psi-mi:Btbd10(display_short)|uniprotkb:Gmrp1(gene name synonym)|uniprotkb:Glucose metabolism-related protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR011333(BTB/POZ fold)|interpro:IPR039885|interpro:IPR039886|mint:Q80X66|ensembl:ENSMUSG00000038187(gene)|ensembl:ENSMUST00000047091(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR000210(BTB/POZ-like)|refseq:NP_598461.1|refseq:XP_006508223.1|refseq:XP_011240192.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:VoTwPedMCjTuxDWUH5cbm1iIUQ410090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9EPU0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6876715|ensembl:ENSMUSP00000075089|uniprotkb:Q3UG00|uniprotkb:Q6GYP5|uniprotkb:Q6PHQ5|uniprotkb:Q8K0N4|uniprotkb:Q99PR4	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rent1_mouse(display_long)|uniprotkb:Upf1(gene name)|psi-mi:Upf1(display_short)|uniprotkb:Rent1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000058301(gene)|ensembl:ENSMUST00000075666(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016787"(hydrolase activity)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR018999|interpro:IPR027417|interpro:IPR040812|interpro:IPR041677|interpro:IPR041679|mint:Q9EPU0|reactome:R-MMU-975956|reactome:R-MMU-975957|go:"GO:0042162"(telomeric DNA binding)|refseq:XP_006509667.1|refseq:XP_006509668.1|refseq:NP_001116301.1|refseq:NP_109605.2|dip:DIP-60114N	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:rwd4XXdf5Uqjtgao/zILckKP8AM10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CJ67	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-21991569|uniprotkb:Q8BSY8|uniprotkb:Q8CJ66|uniprotkb:Q8R175|uniprotkb:Q91Z19|uniprotkb:Q9D5N7|ensembl:ENSMUSP00000053190|ensembl:ENSMUSP00000124505	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:stau2_mouse(display_long)|uniprotkb:Stau2(gene name)|psi-mi:Stau2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001104742.1|refseq:NP_001333974.1|refseq:NP_079579.2|refseq:XP_006495591.1|refseq:XP_006495595.1|refseq:XP_011236689.1|refseq:XP_011236691.1|refseq:XP_017176591.1|ensembl:ENSMUSG00000025920(gene)|ensembl:ENSMUST00000054668(transcript)|ensembl:ENSMUST00000162751(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005874"(microtubule)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0019894"(kinesin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098964"(anterograde dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR044464|interpro:IPR044473|interpro:IPR044474|interpro:IPR044476|mint:Q8CJ67|rcsb pdb:1UHZ	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:94qldY96W9zvErbdJybhouGqEcY10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P35922	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-645094	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:B1AY10	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11707102|uniprotkb:Q3U2A7|uniprotkb:Q3UK95|uniprotkb:Q3UMW1|uniprotkb:Q7TPT4|uniprotkb:Q8CC59|uniprotkb:Q9DBC8|uniprotkb:Q9JKW7|ensembl:ENSMUSP00000095747	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nfx1_mouse(display_long)|uniprotkb:Nfx1(gene name)|psi-mi:Nfx1(display_short)|uniprotkb:Nuclear transcription factor, X box-binding protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001277377.1|refseq:NP_001277378.1|refseq:NP_076228.2|ensembl:ENSMUSG00000028423(gene)|ensembl:ENSMUST00000098143(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000967(Zinc finger, NF-X1-type)|interpro:IPR001374(Single-stranded nucleic acid binding R3H)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR019787|interpro:IPR034076|interpro:IPR034078|interpro:IPR036867|mint:B1AY10|go:"GO:0005730"(nucleolus)	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:fFzQDjd9a1arVzJAhXzDcvmhE7c10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8K2F8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2554251|uniprotkb:Q9CTG8|ensembl:ENSMUSP00000082723	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ls14a_mouse(display_long)|uniprotkb:Fam61a(gene name synonym)|uniprotkb:Rap55a(gene name synonym)|uniprotkb:Protein FAM61A(gene name synonym)|uniprotkb:RNA-associated protein 55A(gene name synonym)|uniprotkb:Lsm14a(gene name)|psi-mi:Lsm14a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080224.1|ensembl:ENSMUSG00000066568(gene)|ensembl:ENSMUST00000085585(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR019050|interpro:IPR025609|interpro:IPR025761|interpro:IPR025762|interpro:IPR025768|mint:Q8K2F8	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ukJG23hyWin24AD3ZzrcPCeQ6Wg10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80WJ7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-774530|uniprotkb:Q3U9F8|uniprotkb:Q3UAQ8|uniprotkb:Q8BN67|uniprotkb:Q8CBT9|uniprotkb:Q8CDL0|uniprotkb:B2RSG8|uniprotkb:Q05CM0|uniprotkb:Q8CGI7|uniprotkb:Q9D052|ensembl:ENSMUSP00000022865	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:lyric_mouse(display_long)|uniprotkb:Lysine-rich CEACAM1 co-isolated protein(gene name synonym)|uniprotkb:3D3/LYRIC(gene name synonym)|uniprotkb:Metastasis adhesion protein(gene name synonym)|uniprotkb:Mtdh(gene name)|psi-mi:Mtdh(display_short)|uniprotkb:Lyric(gene name synonym)|uniprotkb:Metadherin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080278.3|ensembl:ENSMUSG00000022255(gene)|ensembl:ENSMUST00000022865(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR031402|mint:Q80WJ7	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:AwHgSmY3V6vCx2st1bunWPSPIM810090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CR57	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-773925|uniprotkb:Q9D8Q1|ensembl:ENSMUSP00000131489	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl14_mouse(display_long)|uniprotkb:Rpl14(gene name)|psi-mi:Rpl14(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080250.1|ensembl:ENSMUSG00000025794(gene)|ensembl:ENSMUST00000165532(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042273"(ribosomal large subunit biogenesis)|interpro:IPR002784(Ribosomal protein L14)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR039660|interpro:IPR041985|mint:Q9CR57|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Z9bOUoDfmZzjfVXr5d6nHXMv6qA10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CQ10	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2554069|uniprotkb:Q9D7A5|uniprotkb:Q9D2Z2|ensembl:ENSMUSP00000068410|ensembl:ENSMUSP00000109815	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:chmp3_mouse(display_long)|uniprotkb:Chmp3(gene name)|psi-mi:Chmp3(display_short)|uniprotkb:Chromatin-modifying protein 3(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 24(gene name synonym)|uniprotkb:Vps24(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080059.2|ensembl:ENSMUSG00000053119(gene)|ensembl:ENSMUST00000059462(transcript)|ensembl:ENSMUST00000065364(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0030496"(midbody)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:0031902"(late endosome membrane)|interpro:IPR005024(Snf7)|go:"GO:0032467"(positive regulation of cytokinesis)|mint:Q9CQ10|reactome:R-MMU-1632852|reactome:R-MMU-5620971|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|reactome:R-MMU-917729|reactome:R-MMU-9668328|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051258"(protein polymerization)|go:"GO:0061763"(multivesicular body-lysosome fusion)|go:"GO:0061952"(midbody abscission)|go:"GO:1902187"	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:b52oV5XLyniABacZtbbmaLqKd3M10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:E9Q6P5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472026|ensembl:ENSMUSP00000052107	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ttc7b_mouse(display_long)|uniprotkb:Ttc7b(gene name)|psi-mi:Ttc7b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000033530(gene)|ensembl:ENSMUST00000062957(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|mint:E9Q6P5|refseq:NP_001028385.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ZPk8i1GIUVQ38oFmzSf936xq0lE10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P32067	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-911168|ensembl:ENSMUSP00000088365|ensembl:ENSMUSP00000130313	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:la_mouse(display_long)|uniprotkb:La ribonucleoprotein(gene name synonym)|uniprotkb:La autoantigen homolog(gene name synonym)|uniprotkb:Ssb(gene name)|psi-mi:Ssb(display_short)|uniprotkb:Ss-b(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000068882(gene)|ensembl:ENSMUST00000090852(transcript)|ensembl:ENSMUST00000166411(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001682"(tRNA 5'-leader removal)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0008033"(tRNA processing)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042780"(tRNA 3'-end processing)|go:"GO:0071045"(nuclear histone mRNA catabolic process)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002344(Lupus La protein)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR014886(RNA binding motif)|interpro:IPR035979|interpro:IPR036388|interpro:IPR036390|mint:P32067|refseq:NP_001103615.1|refseq:NP_033304.1|dip:DIP-37706N	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:egWOrzRVef4SX0jdKpzPTWEzrjQ10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P35441	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6171593	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tsp1_mouse(display_long)|uniprotkb:Thbs1(gene name)|psi-mi:Thbs1(display_short)|uniprotkb:Tsp1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0043236"(laminin binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|reactome:R-MMU-114608|reactome:R-MMU-186797|reactome:R-MMU-216083|reactome:R-MMU-5173214|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016477"(cell migration)|interpro:IPR001881(EGF-like calcium-binding)|mint:P35441|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR017897|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:0j9TPpvxNW9TNMFkFCNo+9wD3fA10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3U4G0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470987|ensembl:ENSMUSP00000106543|uniprotkb:Q80WT3|uniprotkb:Q8C1X6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cdin1_mouse(display_long)|uniprotkb:Cdin1(gene name)|psi-mi:Cdin1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000040282(gene)|ensembl:ENSMUST00000110918(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030218"(erythrocyte differentiation)|interpro:IPR029404|mint:Q3U4G0|refseq:NP_001139370.1|refseq:NP_997147.3	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:gJ5bh/GvxiLfIKZVcJBRB/LWpzY10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q91YD3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6097113|ensembl:ENSMUSP00000022535|ensembl:ENSMUSP00000152897|uniprotkb:Q6NZE3	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dcp1a_mouse(display_long)|uniprotkb:Dcp1a(gene name)|psi-mi:Dcp1a(display_short)|uniprotkb:Mitc1(gene name synonym)|uniprotkb:Smif(gene name synonym)|uniprotkb:MAD homolog 4-interacting transcription coactivator 1(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:Transcription factor SMIF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q91YD3|reactome:R-MMU-430039|reactome:R-MMU-450385|reactome:R-MMU-450513|reactome:R-MMU-975957|ensembl:ENSMUSG00000021962(gene)|ensembl:ENSMUST00000022535(transcript)|ensembl:ENSMUST00000225196(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_598522.3	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:GNFxv657QCnGA5H6YA6nxBPFGpE10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80X50	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11664310|uniprotkb:Q8BIT6|uniprotkb:Q8BIW4|uniprotkb:Q8BJ01|uniprotkb:Q8CIG7|uniprotkb:Q8K102|uniprotkb:Q9CRT6|ensembl:ENSMUSP00000143459	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ubp2l_mouse(display_long)|uniprotkb:Ubap2l(gene name)|psi-mi:Ubap2l(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001159455.1|refseq:NP_001159456.1|refseq:NP_001159457.1|refseq:NP_001159458.1|refseq:NP_082751.1|refseq:XP_006502235.1|ensembl:ENSMUSG00000042520(gene)|ensembl:ENSMUST00000196843(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031519"(PcG protein complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|mint:Q80X50|rcsb pdb:1WJ7	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ucHEy1MXF7PTEdwLChr6zAOqtcM10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CHC4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-775693	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:synj1_mouse(display_long)|uniprotkb:Synj1(gene name)|psi-mi:Synj1(display_short)|uniprotkb:Kiaa0910(gene name synonym)|uniprotkb:Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR015047(Region of unknown function DUF1866)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002013(Synaptojanin, N-terminal)|interpro:IPR034971|interpro:IPR034972|interpro:IPR035979|interpro:IPR036691|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:Q8CHC4|go:"GO:0003723"(RNA binding)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014015"(positive regulation of gliogenesis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030118"(clathrin coat)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034097"(response to cytokine)|go:"GO:0034595"(phosphatidylinositol phosphate 5-phosphatase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0043812"(phosphatidylinositol-4-phosphate phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|go:"GO:1904980"(positive regulation of endosome organization)|go:"GO:1990175"(EH domain binding)|reactome:R-MMU-1660499|reactome:R-MMU-1855183|reactome:R-MMU-1855204|reactome:R-MMU-8856828	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:jBMEFlptiz90uS1F1ajBc7zR3vo10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P62830	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2365752|uniprotkb:P23131|uniprotkb:P24048|uniprotkb:Q29246|uniprotkb:Q3THU4|uniprotkb:Q9CZE6|uniprotkb:Q9DCQ4|ensembl:ENSMUSP00000099435	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl23_mouse(display_long)|uniprotkb:Rpl23(gene name)|psi-mi:Rpl23(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_075029.1|refseq:XP_003688806.1|refseq:XP_003689266.1|ensembl:ENSMUSG00000071415(gene)|ensembl:ENSMUST00000103146(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032986"(protein-DNA complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000218(Ribosomal protein L14b/L23e)|interpro:IPR019972|interpro:IPR036853|mint:P62830|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:TiSVU2W4+lkwf12eb4+vG6IFlZA10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8BSQ9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-5744069|uniprotkb:E9QPW1|uniprotkb:Q05C64|uniprotkb:Q05CL6|uniprotkb:Q7TMP1|uniprotkb:Q7TNU2|uniprotkb:Q9CV51|ensembl:ENSMUSP00000107724	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:pb1_mouse(display_long)|uniprotkb:Pbrm1(gene name)|psi-mi:Pbrm1(display_short)|uniprotkb:Baf180(gene name synonym)|uniprotkb:Pb1(gene name synonym)|uniprotkb:BRG1-associated factor 180(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0043044"|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001487(Bromodomain)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR018359|interpro:IPR036427|interpro:IPR036910|interpro:IPR037382|interpro:IPR037968|interpro:IPR043151|mint:Q8BSQ9|rcsb pdb:2YQD|reactome:R-MMU-3214858|ensembl:ENSMUSG00000042323(gene)|ensembl:ENSMUST00000112095(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0001825"(blastocyst formation)|go:"GO:0001890"(placenta development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003349"(epicardium-derived cardiac endothelial cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016586"(RSC-type complex)|dip:DIP-48885N|reactome:R-MMU-8939243	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:7T640XCpm6UfVO9GB/HJKZZbd7E10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q62443	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470897|ensembl:ENSMUSP00000026670	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nptx1_mouse(display_long)|uniprotkb:Nptx1(gene name)|psi-mi:Nptx1(display_short)|uniprotkb:Neuronal pentraxin I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000025582(gene)|ensembl:ENSMUST00000026670(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0030133"(transport vesicle)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|mint:Q62443|refseq:NP_032756.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ddE8h5JD7XtrGle7yD9q+E4m/co10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:A2AF47	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16733818|ensembl:ENSMUSP00000033419|uniprotkb:Q5KTP7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:doc11_mouse(display_long)|uniprotkb:Activated Cdc42-associated guanine nucleotide exchange factor(gene name synonym)|uniprotkb:Zizimin-2(gene name synonym)|uniprotkb:Dock11(gene name)|psi-mi:Dock11(display_short)|uniprotkb:Ziz2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000031093(gene)|ensembl:ENSMUST00000033419(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021816|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR035892|interpro:IPR037809|interpro:IPR043161|interpro:IPR043162|mint:A2AF47|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-983231|refseq:NP_001009947.2	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Hj/RFYqY5pvpk7vrJ1VKTZ0K0e010090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3UH60	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16724475|ensembl:ENSMUSP00000097777|uniprotkb:Q8C1W5|uniprotkb:Q8CDG9|uniprotkb:Q8CHA2	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dip2b_mouse(display_long)|uniprotkb:Dip2b(gene name)|psi-mi:Dip2b(display_short)|uniprotkb:Kiaa1463(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000023026(gene)|ensembl:ENSMUST00000100203(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR010506(DMAP1-binding)|interpro:IPR037337|interpro:IPR042099|mint:Q3UH60|refseq:NP_001152833.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:fgjJT8HpeVRm1osKj8p2Dx7WxU810090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8K2D3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16369796|ensembl:ENSMUSP00000049146|uniprotkb:Q3THV7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:edc3_mouse(display_long)|uniprotkb:YjeF domain-containing protein 1(gene name synonym)|uniprotkb:Edc3(gene name)|psi-mi:Edc3(display_short)|uniprotkb:Yjdc(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:1990174"(phosphodiesterase decapping endonuclease activity)|interpro:IPR004443(YjeF-related protein, N-terminal)|interpro:IPR019050|interpro:IPR025609|interpro:IPR025762|interpro:IPR034107|interpro:IPR036652|mint:Q8K2D3|reactome:R-MMU-430039|ensembl:ENSMUSG00000038957(gene)|ensembl:ENSMUST00000043990(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|refseq:NP_722494.1|refseq:XP_011241062.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:gxI+R4pKdhtjglIi5z4PNMDktbk10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P27659	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2526690|uniprotkb:O89071|uniprotkb:Q91VJ6|ensembl:ENSMUSP00000080354	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl3_mouse(display_long)|uniprotkb:Rpl3(gene name)|psi-mi:Rpl3(display_short)|uniprotkb:J1 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_038790.2|ensembl:ENSMUSG00000060036(gene)|ensembl:ENSMUST00000081650(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045202"(synapse)|go:"GO:0071353"(cellular response to interleukin-4)|interpro:IPR000597(Ribosomal protein L3)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR019926|mint:P27659|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:GrC8OWBLXBaBuOrzEOvyR6cid1A10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6ZPQ6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16744915|ensembl:ENSMUSP00000124111|uniprotkb:Q9R1P5	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:pitm2_mouse(display_long)|uniprotkb:Pitpnm2(gene name)|psi-mi:Pitpnm2(display_short)|uniprotkb:Drosophila retinal degeneration B homolog 2(gene name synonym)|uniprotkb:Kiaa1457(gene name synonym)|uniprotkb:Nir3(gene name synonym)|uniprotkb:Phosphatidylinositol transfer protein, membrane-associated 2(gene name synonym)|uniprotkb:Pyk2 N-terminal domain-interacting receptor 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000029406(gene)|ensembl:ENSMUST00000161938(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008525"(phosphatidylcholine transporter activity)|go:"GO:0008526"(phosphatidylinositol transfer activity)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044297"(cell body)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|interpro:IPR001666(Phosphatidylinositol transfer protein)|interpro:IPR023214|interpro:IPR023393|interpro:IPR031315|interpro:IPR036412|mint:Q6ZPQ6|reactome:R-MMU-1483226|interpro:IPR004177(DDHD)|refseq:NP_001276401.1|refseq:NP_035386.1|refseq:XP_017176233.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:4zrvxwjon6qsbpA3n5INhmMp/KQ10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8BRT1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-776004|uniprotkb:Q8CHE3|uniprotkb:Q99JI3|uniprotkb:Q9DB80	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:clap2_mouse(display_long)|uniprotkb:Cytoplasmic linker-associated protein 2(gene name synonym)|uniprotkb:Clasp2(gene name)|psi-mi:Clasp2(display_short)|uniprotkb:Kiaa0627(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001273528.1|refseq:NP_001273529.1|refseq:NP_001273530.1|refseq:NP_001273531.1|refseq:NP_001273532.1|mint:Q8BRT1|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024395|interpro:IPR034085|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006903"(vesicle targeting)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008017"(microtubule binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045180"(basal cortex)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903754"(cortical microtubule plus-end)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|rcsb pdb:3WOZ|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ACnxijHc8A5KYqR4CDmSg2U5OYk10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q5F2E7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11567759|uniprotkb:Q80TF1|uniprotkb:Q3V195|uniprotkb:Q3TCE2|ensembl:ENSMUSP00000098365	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nufp2_mouse(display_long)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:Kiaa1321(gene name synonym)|uniprotkb:Nufip2(gene name)|psi-mi:Nufip2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001019376.1|refseq:XP_006534125.1|ensembl:ENSMUSG00000037857(gene)|ensembl:ENSMUST00000100802(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q5F2E7	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:rckz1rTUY3/RppScoXLaw1Z9ipU10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P62843	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2526764|uniprotkb:P11174|uniprotkb:Q52KC9|ensembl:ENSMUSP00000069004	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rs15_mouse(display_long)|uniprotkb:Rps15(gene name)|psi-mi:Rps15(display_short)|uniprotkb:Rig(gene name synonym)|uniprotkb:RIG protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000063457(gene)|ensembl:ENSMUST00000068408(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0045202"(synapse)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097421"(liver regeneration)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|interpro:IPR002222(Ribosomal protein S19/S15)|interpro:IPR005713(Ribosomal protein S15, eukaryotic/archaeal)|interpro:IPR020934|interpro:IPR023575|mint:P62843|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|refseq:NP_033117.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:lJJOew1txuTwFlhKu4Z+AkPS5H010090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8BKI2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-9030490|uniprotkb:Q80TK4|ensembl:ENSMUSP00000064336	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tnr6b_mouse(display_long)|uniprotkb:Tnrc6b(gene name)|psi-mi:Tnrc6b(display_short)|uniprotkb:Kiaa1093(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_659061.2|dip:DIP-48568N|ensembl:ENSMUSG00000047888(gene)|ensembl:ENSMUST00000067689(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR019486|interpro:IPR032226|interpro:IPR033500|interpro:IPR034925|interpro:IPR035979|mint:Q8BKI2|reactome:R-MMU-426496	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:zFkNbprE9NdhNf4a/bcBU+nHcac10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:E9Q3L2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-773641|uniprotkb:Q3UVT5|uniprotkb:Q6DIC7|uniprotkb:Q7TNG2|uniprotkb:Q80Y45	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:pi4ka_mouse(display_long)|uniprotkb:Pik4(gene name synonym)|uniprotkb:Pik4ca(gene name synonym)|uniprotkb:Pi4ka(gene name)|psi-mi:Pi4ka(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001001983.2|interpro:IPR016024(Armadillo-type fold)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR018936|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR042236|refseq:XP_006522097.1|interpro:IPR036940|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0046786"(viral replication complex formation and maintenance)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|reactome:R-MMU-1483248|reactome:R-MMU-1660514|mint:E9Q3L2	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:IndUgD7njY39mo58MVLNKGSeD4c10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CJG1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2291996|uniprotkb:A1L365|ensembl:ENSMUSP00000095498|ensembl:ENSMUSP00000159361	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ago1_mouse(display_long)|uniprotkb:Ago1(gene name)|psi-mi:Ago1(display_short)|uniprotkb:Argonaute RISC catalytic component 1(gene name synonym)|uniprotkb:Eif2c1(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 1(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_700452.2|refseq:NP_001304102.1|ensembl:ENSMUSG00000041530(gene)|ensembl:ENSMUST00000097888(transcript)|ensembl:ENSMUST00000239428(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070578"(RISC-loading complex)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG1|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:l/WmIsnfJjifEOoxOyG9zDo2ljQ10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P47962	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-773940|uniprotkb:Q9CR19|ensembl:ENSMUSP00000080854	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl5_mouse(display_long)|uniprotkb:Rpl5(gene name)|psi-mi:Rpl5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_058676.1|ensembl:ENSMUSG00000058558(gene)|ensembl:ENSMUST00000082223(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1905017"(positive regulation of isoleucine-tRNA ligase activity)|go:"GO:1905020"(positive regulation of methionine-tRNA ligase activity)|go:"GO:1905023"(positive regulation of threonine-tRNA ligase activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR005485(Ribosomal protein L5, eukaryotic)|interpro:IPR025607|mint:P47962|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:29DmVSczDJV/5gL/nPYYBBEdo9o10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8K310	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-1216295|ensembl:ENSMUSP00000125761|ensembl:ENSMUSP00000158074|ensembl:ENSMUSP00000158537	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:matr3_mouse(display_long)|uniprotkb:Matr3(gene name)|psi-mi:Matr3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_034901.2|rcsb pdb:1X4F|rcsb pdb:1X4D|ensembl:ENSMUSG00000037236(gene)|ensembl:ENSMUST00000166793(transcript)|ensembl:ENSMUST00000235199(transcript)|ensembl:ENSMUST00000237744(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034928|interpro:IPR034930|interpro:IPR035979|mint:Q8K310	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:AwtFbI+oRfha+mn/v3yzG6bNXYg10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TSH2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-911437|ensembl:ENSMUSP00000050788	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kpbb_mouse(display_long)|uniprotkb:Phkb(gene name)|psi-mi:Phkb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_955517.1|ensembl:ENSMUSG00000036879(gene)|ensembl:ENSMUST00000053771(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|interpro:IPR008734(Phosphorylase kinase alphabeta)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR011613(Glycoside hydrolase 15-related)|mint:Q7TSH2|reactome:R-MMU-70221|refseq:XP_006530595.1|refseq:XP_006530596.1|refseq:XP_006530597.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:qRovReuecws5KcJl6XVcnVO5FW410090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8BWS5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472832|ensembl:ENSMUSP00000051805|uniprotkb:Q69Z30	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:grin3_mouse(display_long)|uniprotkb:Gprin3(gene name)|psi-mi:Gprin3(display_short)|uniprotkb:Kiaa2027(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000045441(gene)|ensembl:ENSMUST00000051065(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0031175"(neuron projection development)|interpro:IPR026646|interpro:IPR032745|mint:Q8BWS5|refseq:NP_899006.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:TUt7HEqIihPNC+yWsH42oCCXRVQ10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O70133	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2657677|uniprotkb:O35931|uniprotkb:O54703|uniprotkb:Q5FWY1|uniprotkb:Q6R5F7|uniprotkb:Q9CSA2	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dhx9_mouse(display_long)|uniprotkb:Dhx9(gene name)|psi-mi:Dhx9(display_short)|uniprotkb:Ddx9(gene name synonym)|uniprotkb:Nuclear DNA helicase II(gene name synonym)|uniprotkb:DEAH box protein 9(gene name synonym)|uniprotkb:RNA helicase A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_031868.2|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR007502(Helicase-associated region)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001069"(regulatory region RNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005844"(polysome)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007623"(circadian rhythm)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016442"(RISC complex)|go:"GO:0016604"(nuclear body)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033679"(3'-5' DNA/RNA helicase activity)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045142"(triplex DNA binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0047429"(nucleoside-triphosphate diphosphatase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070269"(pyroptosis)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904973"(positive regulation of viral translation)|go:"GO:1905172"(RISC complex binding)|go:"GO:1905538"(polysome binding)|go:"GO:1905698"(positive regulation of polysome binding)|go:"GO:1990518"(single-stranded 3'-5' DNA helicase activity)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000765"(regulation of cytoplasmic translation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|rcsb pdb:1UIL|rcsb pdb:1WHQ|rcsb pdb:2RS6|rcsb pdb:2RS7|reactome:R-MMU-1810476|reactome:R-MMU-3134963|reactome:R-MMU-72163|interpro:IPR027417|mint:O70133|interpro:IPR044445|interpro:IPR044446|interpro:IPR044447	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:8NHxvbw0StglewhGm3e7Pi/8oOg10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q69ZU6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-9673461|uniprotkb:Q3TP01|uniprotkb:Q3UWV1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ths7a_mouse(display_long)|uniprotkb:Thsd7a(gene name)|psi-mi:Thsd7a(display_short)|uniprotkb:Gm837(gene name synonym)|uniprotkb:Kiaa0960(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	mint:Q69ZU6|interpro:IPR000884(Thrombospondin, type I)|refseq:NP_001158277.1|interpro:IPR036383|interpro:IPR044004|go:"GO:0001525"(angiogenesis)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0098846"(podocyte foot)|reactome:R-MMU-5173214	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:/qTgHz4eRmV8fo7eOtIiStWEzrw10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O88532	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-645485|uniprotkb:Q3TY30|uniprotkb:Q8BS85|uniprotkb:Q8CGG5|uniprotkb:Q91VZ0|uniprotkb:Q9CT34|ensembl:ENSMUSP00000118911	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:zfr_mouse(display_long)|uniprotkb:Zfr(gene name)|psi-mi:Zfr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035897.2|ensembl:ENSMUSG00000022201(gene)|ensembl:ENSMUST00000122941(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR006561(DZF)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043519|mint:O88532	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ncNwFUEUk0r2XotuXm/9Tt4iB5w10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CC12	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470848|ensembl:ENSMUSP00000106329|uniprotkb:A2AW10|uniprotkb:Q149P8|uniprotkb:Q3U032	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cdan1_mouse(display_long)|uniprotkb:Cdan1(gene name)|psi-mi:Cdan1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000027284(gene)|ensembl:ENSMUST00000110701(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0008104"(protein localization)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031497"(chromatin assembly)|interpro:IPR028171|interpro:IPR040031|mint:Q8CC12|refseq:NP_081167.2	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:5Nyg/Fnh9WKYy3DFp/o8OTH4LGA10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P18826	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470825|ensembl:ENSMUSP00000061991|uniprotkb:A2AI90	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kpb1_mouse(display_long)|uniprotkb:Phka1(gene name)|psi-mi:Phka1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000034055(gene)|ensembl:ENSMUST00000052012(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR008734(Phosphorylase kinase alphabeta)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR011613(Glycoside hydrolase 15-related)|interpro:IPR012341(Six-hairpin glycosidase)|mint:P18826|reactome:R-MMU-70221|refseq:NP_032858.2	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:m6KkLpQv72gScTWLDJ2f1g4mtuo10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3TLH4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6908845|ensembl:ENSMUSP00000138433|uniprotkb:E9QKG5|uniprotkb:Q05CS4|uniprotkb:Q05DM5|uniprotkb:Q3TKF3|uniprotkb:Q3UXU5|uniprotkb:Q4FZE4|uniprotkb:Q66K03|uniprotkb:Q6P3F4|uniprotkb:Q80TK3|uniprotkb:Q80YR0|uniprotkb:Q8BMJ4|uniprotkb:Q8C1K7|uniprotkb:Q8CGH3	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:prc2c_mouse(display_long)|uniprotkb:Prrc2c(gene name)|psi-mi:Prrc2c(display_short)|uniprotkb:Bat2d(gene name synonym)|uniprotkb:Bat2d1(gene name synonym)|uniprotkb:Bat2l2(gene name synonym)|uniprotkb:Kiaa1096(gene name synonym)|uniprotkb:BAT2 domain-containing protein 1(gene name synonym)|uniprotkb:HLA-B-associated transcript 2-like 2(gene name synonym)|uniprotkb:Proline-rich and coiled-coil-containing protein 2C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_011237086.1|ensembl:ENSMUSG00000040225(gene)|ensembl:ENSMUST00000182660(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0034063"(stress granule assembly)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:Q3TLH4|refseq:NP_001074759.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:lJHI4KKm0yJpyg2mURs2zCXOrSY10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q08460	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9Z1X4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6260790|ensembl:ENSMUSP00000065770|uniprotkb:Q8BP80|uniprotkb:Q8K588|uniprotkb:Q8C2H8|uniprotkb:Q812A1|uniprotkb:Q80VD5	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ilf3_mouse(display_long)|uniprotkb:Ilf3(gene name)|psi-mi:Ilf3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001264250.1|ensembl:ENSMUSG00000032178(gene)|ensembl:ENSMUST00000067646(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006479"(protein methylation)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR033099|interpro:IPR043519|mint:Q9Z1X4|rcsb pdb:4AT7|rcsb pdb:4AT8|rcsb pdb:4AT9|rcsb pdb:4ATB|rcsb pdb:5DV7|refseq:XP_006510094.1|refseq:NP_001036172.1|refseq:NP_001036173.1|refseq:NP_034691.2|refseq:NP_001264251.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:vxZan3L6NAseX1Ib9Z7MQ82CM3E10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P07934	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470873|ensembl:ENSMUSP00000026617	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:phkg1_mouse(display_long)|uniprotkb:Phkg1(gene name)|psi-mi:Phkg1(display_short)|uniprotkb:Phkg(gene name synonym)|uniprotkb:Phosphorylase kinase subunit gamma-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PHKG1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000026617(transcript)|go:"GO:0004689"(phosphorylase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR002291(Phosphorylase kinase, gamma catalytic subunit)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P07934|reactome:R-MMU-70221|ensembl:ENSMUSG00000025537(gene)|refseq:NP_035209.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:oWhiqhcqtIelRPU5Z0TI4T9lskc10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TMK9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2735641|uniprotkb:O88991|uniprotkb:Q2YDV8|uniprotkb:Q68ED6|uniprotkb:Q80YV6|uniprotkb:Q8BGP1|uniprotkb:Q8C5K6|uniprotkb:Q8CGC2|uniprotkb:Q91ZR0|uniprotkb:Q99KU9|uniprotkb:Q9QYF4|ensembl:ENSMUSP00000133649	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:hnrpq_mouse(display_long)|uniprotkb:Syncrip(gene name)|psi-mi:Syncrip(display_short)|uniprotkb:Hnrpq(gene name synonym)|uniprotkb:Nsap1(gene name synonym)|uniprotkb:Nsap1l(gene name synonym)|uniprotkb:Synaptotagmin-binding, cytoplasmic RNA-interacting protein(gene name synonym)|uniprotkb:Glycine- and tyrosine-rich RNA-binding protein(gene name synonym)|uniprotkb:NS1-associated protein 1(gene name synonym)|uniprotkb:pp68(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001271257.1|refseq:NP_062640.2|refseq:NP_062770.1|refseq:NP_001298042.1|ensembl:ENSMUSG00000032423(gene)|ensembl:ENSMUST00000173801(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006397"(mRNA processing)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006535(HnRNP R and Q splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034544|interpro:IPR034548|interpro:IPR035979|interpro:IPR041337|mint:Q7TMK9	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Ljuz8koebOL7L9jFBaevQYHinzw10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99JY8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-773683|uniprotkb:Q3TVM4|uniprotkb:Q3TXR7|uniprotkb:Q8BTB7|ensembl:ENSMUSP00000065719	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:plpp3_mouse(display_long)|uniprotkb:Plpp3(gene name)|psi-mi:Plpp3(display_short)|uniprotkb:Lipid phosphate phosphohydrolase 3(gene name synonym)|uniprotkb:Lpp3(gene name synonym)|uniprotkb:PAP2-beta(gene name synonym)|uniprotkb:Phosphatidate phosphohydrolase type 2b(gene name synonym)|uniprotkb:Phosphatidic acid phosphatase 2b(gene name synonym)|uniprotkb:Ppap2b(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_542122.1|ensembl:ENSMUSG00000028517(gene)|ensembl:ENSMUST00000064139(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001568"(blood vessel development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005178"(integrin binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006670"(sphingosine metabolic process)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008195"(phosphatidate phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042392"(sphingosine-1-phosphate phosphatase activity)|go:"GO:0042577"(lipid phosphatase activity)|go:"GO:0044328"(canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration)|go:"GO:0044329"(canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion)|go:"GO:0044330"(canonical Wnt signaling pathway involved in positive regulation of wound healing)|go:"GO:0045121"(membrane raft)|go:"GO:0046839"(phospholipid dephosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0106235"(ceramide-1-phosphate phosphatase activity)|go:"GO:1902068"(regulation of sphingolipid mediated signaling pathway)|interpro:IPR000326(Phosphatidic acid phosphatase type 2/haloperoxidase)|interpro:IPR028675|interpro:IPR036938|interpro:IPR043216|mint:Q99JY8|reactome:R-MMU-1660661	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:k0j2BFjYFftNCFSr6/PrQfurHck10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TQH0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6908203|ensembl:ENSMUSP00000035415|uniprotkb:Q80XN9|uniprotkb:Q8K059	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:atx2l_mouse(display_long)|uniprotkb:Atxn2l(gene name)|psi-mi:Atxn2l(display_short)|uniprotkb:A2lp(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_006507788.1|ensembl:ENSMUSG00000032637(gene)|ensembl:ENSMUST00000040202(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010603"(regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0034063"(stress granule assembly)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR025852|mint:Q7TQH0|refseq:NP_898841.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:7v7iuPRti2err2QrmJIGoWqEM3U10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P56942	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26450331|ensembl:ENSMUSP00000044352|uniprotkb:Q9D220	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mch_mouse(display_long)|uniprotkb:Pmch(gene name)|psi-mi:Pmch(display_short)|uniprotkb:Mch(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000048621(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007631"(feeding behavior)|go:"GO:0009409"(response to cold)|go:"GO:0030354"(melanin-concentrating hormone activity)|go:"GO:0031777"(type 1 melanin-concentrating hormone receptor binding)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042756"(drinking behavior)|go:"GO:0045202"(synapse)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046005"(positive regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|interpro:IPR005456(Pre-pro melanin-concentrating hormone)|mint:P56942|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUSG00000035383(gene)|refseq:NP_084247.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:l3UbZeUaSJTBhc0jao6eg+D8Q4U10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CXY6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2312782|uniprotkb:Q3U083|uniprotkb:Q5RKG0|uniprotkb:Q8CCY9|uniprotkb:Q99KS3|ensembl:ENSMUSP00000001042	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ilf2_mouse(display_long)|uniprotkb:Ilf2(gene name)|psi-mi:Ilf2(display_short)|uniprotkb:Nf45(gene name synonym)|uniprotkb:Nuclear factor of activated T-cells 45 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080650.1|ensembl:ENSMUSG00000001016(gene)|ensembl:ENSMUST00000001042(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR043519|mint:Q9CXY6|rcsb pdb:4AT7|rcsb pdb:4AT8|rcsb pdb:4AT9|rcsb pdb:4ATB|reactome:R-MMU-6798695	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:HwUDuY6Ev7csoTThxZCW8nJT88o10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P24270	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2924912|uniprotkb:Q3TXQ6|ensembl:ENSMUSP00000028610	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cata_mouse(display_long)|uniprotkb:Cat(gene name)|psi-mi:Cat(display_short)|uniprotkb:Cas-1(gene name synonym)|uniprotkb:Cas1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0055093"(response to hyperoxia)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0080184"(response to phenylpropanoid)|interpro:IPR002226(Catalase)|interpro:IPR010582(Catalase-related)|interpro:IPR011614(Catalase, N-terminal)|interpro:IPR018028|interpro:IPR020835|interpro:IPR024708|interpro:IPR024711|interpro:IPR040333|mint:P24270|reactome:R-MMU-3299685|reactome:R-MMU-6798695|reactome:R-MMU-9033241|go:"GO:0051781"(positive regulation of cell division)|ensembl:ENSMUSG00000027187(gene)|ensembl:ENSMUST00000028610(transcript)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0004096"(catalase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009642"(response to light intensity)|go:"GO:0009650"(UV protection)|go:"GO:0010193"(response to ozone)|go:"GO:0010288"(response to lead ion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0016209"(antioxidant activity)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019899"(enzyme binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|refseq:NP_033934.2	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Ahsw8/VMIQAUw7mWuBSFRn9g/3M10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8R081	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-647483|uniprotkb:O54789|uniprotkb:Q8K0S7|uniprotkb:Q499X2|ensembl:ENSMUSP00000049407|ensembl:ENSMUSP00000133728	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:hnrpl_mouse(display_long)|uniprotkb:Hnrpl(gene name synonym)|uniprotkb:Hnrnpl(gene name)|psi-mi:Hnrnpl(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_796275.3|refseq:XP_006539621.1|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006536(HnRNP-L/PTB/hephaestus splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021790|interpro:IPR034816|interpro:IPR034817|interpro:IPR035005|interpro:IPR035008|interpro:IPR035979|mint:Q8R081|rcsb pdb:3S01|rcsb pdb:3TYT|reactome:R-MMU-72163|reactome:R-MMU-72203|go:"GO:1990715"(mRNA CDS binding)|ensembl:ENSMUSG00000015165(gene)|ensembl:ENSMUST00000038572(transcript)|ensembl:ENSMUST00000174548(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0045120"(pronucleus)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0097157"(pre-mRNA intronic binding)|go:"GO:1902416"(positive regulation of mRNA binding)	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:BApt4fekoyJ285Ve13kxstcLbV010090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6ZPR4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16728165|ensembl:ENSMUSP00000109809|uniprotkb:B2RUK3|uniprotkb:Q8C3E7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kcnt1_mouse(display_long)|uniprotkb:Kcnt1(gene name)|psi-mi:Kcnt1(display_short)|uniprotkb:Kiaa1422(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000058740(gene)|ensembl:ENSMUST00000114172(transcript)|go:"GO:0005228"(intracellular sodium activated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR013099(Ion transport 2)|mint:Q6ZPR4|refseq:NP_001289280.1|refseq:NP_780671.2	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:dqty8xDH9pIQhzgbYTeSOo4tLjA10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CQE6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2657826|ensembl:ENSMUSP00000020004	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P39087	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-396914|uniprotkb:Q60933|ensembl:ENSMUSP00000101124|ensembl:ENSMUSP00000151921	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:grik2_mouse(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym)|uniprotkb:Glutamate receptor beta-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_017169293.1|ensembl:ENSMUSG00000056073(gene)|ensembl:ENSMUST00000105484(transcript)|ensembl:ENSMUST00000218823(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|mint:P39087|reactome:R-MMU-451307|reactome:R-MMU-451308	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:6sgY8SzX07HzilLLeDg3pV+sXkc10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O35681	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-457995|uniprotkb:P97791|uniprotkb:Q80WV1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:syt3_mouse(display_long)|uniprotkb:Syt3(gene name)|psi-mi:Syt3(display_short)|uniprotkb:Synaptotagmin III(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001107588.1|refseq:NP_057872.3|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR028682|mint:O35681|interpro:IPR035892	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:mkfffZn3WWGhztw/udRiKd0LUJ010090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O35099	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-777493|uniprotkb:Q14AY5|ensembl:ENSMUSP00000093485	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:m3k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:Map3k5(gene name)|psi-mi:Map3k5(display_short)|uniprotkb:Ask1(gene name synonym)|uniprotkb:Mekk5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_032606.4|dip:DIP-38055N|ensembl:ENSMUSG00000071369(gene)|ensembl:ENSMUST00000095806(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010941"(regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902170"(cellular response to reactive nitrogen species)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:O35099|reactome:R-MMU-2559580	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:i1P8YtUNmpFauFUVVxzsMYoQYOw10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q64105	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470795|uniprotkb:Q63996	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:spre_mouse(display_long)|uniprotkb:Spr(gene name)|psi-mi:Spr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0004757"(sepiapterin reductase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006558"(L-phenylalanine metabolic process)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0010033"(response to organic substance)|go:"GO:0019889"(pteridine metabolic process)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046146"(tetrahydrobiopterin metabolic process)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050882"(voluntary musculoskeletal movement)|rcsb pdb:1NAS|rcsb pdb:1OAA|rcsb pdb:1SEP|reactome:R-MMU-1474151|reactome:R-MMU-203615|mint:Q64105|interpro:IPR036291|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR006393(Sepiapterin reductase)	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Y4ePCWcq2RI0t59kgHibLyHd6yM10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8C3F2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16728136|ensembl:ENSMUSP00000073082|uniprotkb:Q3U0F6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:f120c_mouse(display_long)|uniprotkb:Protein FAM120C(gene name synonym)|uniprotkb:Fam120c(gene name)|psi-mi:Fam120c(display_short)|uniprotkb:ORF34(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000025262(gene)|go:"GO:0005634"(nucleus)|interpro:IPR026784|interpro:IPR026785|interpro:IPR029060|mint:Q8C3F2|ensembl:ENSMUST00000073364(transcript)|refseq:NP_932773.2	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:7t8xHEO+ShbLsdqIbH6xQm7UcPw10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9Z321	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16728364|ensembl:ENSMUSP00000023465|ensembl:ENSMUSP00000156132	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:top3b_mouse(display_long)|uniprotkb:DNA topoisomerase III beta-1(gene name synonym)|uniprotkb:Top3b(gene name)|psi-mi:Top3b(display_short)|uniprotkb:Top3b1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26472902|imex:IM-28526-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000022779(gene)|ensembl:ENSMUST00000023465(transcript)|ensembl:ENSMUST00000232581(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003916"(DNA topoisomerase activity)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007059"(chromosome segregation)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|mint:Q9Z321|refseq:NP_001313505.1|refseq:NP_035754.1|refseq:XP_006522054.1|refseq:XP_006522055.1|refseq:XP_006522057.1|refseq:XP_006522058.1|refseq:XP_017172426.1	-	-	-	comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|figure legend:ST4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:9m6mpZ7aIV3fx3bU6opc3sFN3SA10090	rigid:Voa18/3ovMD3U2R2Hmf34Zsu3kw	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CJG0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9QZF2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8333546|intact:MINT-4096508|ensembl:ENSMUSP00000047199	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:gpc1_mouse(display_long)|uniprotkb:Gpc1(gene name)|psi-mi:Gpc1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_057905.1|ensembl:ENSMUSG00000034220(gene)|ensembl:ENSMUST00000045970(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030200"(heparan sulfate proteoglycan catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032288"(myelin assembly)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043236"(laminin binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070052"(collagen V binding)|go:"GO:1905475"(regulation of protein localization to membrane)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR001863(Glypican)|interpro:IPR015502(Glypican1)|interpro:IPR019803|mint:Q9QZF2|reactome:R-MMU-1971475|reactome:R-MMU-2022928|reactome:R-MMU-2024096|reactome:R-MMU-202733|reactome:R-MMU-376176|reactome:R-MMU-975634	-	-	comment:mint|function:Cell surface proteoglycan that bears heparan sulfate. May play an important role in the trophic and injury responses of neurons	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ZgjHg2dYJ7bErmaacYVvVQFB1Mc10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9DBY8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8339942|uniprotkb:Q8BW27|uniprotkb:Q3USC4|intact:MINT-4104517|uniprotkb:Q8K2B5|ensembl:ENSMUSP00000027797	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nvl_mouse(display_long)|uniprotkb:Nvl(gene name)|psi-mi:Nvl(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080447.1|ensembl:ENSMUSG00000026516(gene)|ensembl:ENSMUST00000027797(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:1904749"(regulation of protein localization to nucleolus)|go:"GO:1990275"(preribosome binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|interpro:IPR031996|interpro:IPR038100|interpro:IPR041569|mint:Q9DBY8|rcsb pdb:2RRE	-	-	comment:mint	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:fUPan5RrtNtqdP9FfB3ywQVbKZQ10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99KV1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8328260|uniprotkb:Q8VHB1|uniprotkb:Q8VCY1|intact:MINT-1847287|uniprotkb:A6X957|uniprotkb:Q543I7|uniprotkb:Q8BK79|ensembl:ENSMUSP00000004574|ensembl:ENSMUSP00000126828|ensembl:ENSMUSP00000137542	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:djb11_mouse(display_long)|uniprotkb:Dnajb11(gene name)|psi-mi:Dnajb11(display_short)|uniprotkb:ER-associated Hsp40 co-chaperone(gene name synonym)|uniprotkb:ER-associated DNAJ(gene name synonym)|uniprotkb:APOBEC1-binding protein 2(gene name synonym)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080676.3|refseq:NP_001177733.1|refseq:NP_001177734.1|dip:DIP-60531N|ensembl:ENSMUSG00000004460(gene)|ensembl:ENSMUST00000004574(transcript)|ensembl:ENSMUST00000166487(transcript)|ensembl:ENSMUST00000178320(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0016556"(mRNA modification)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|mint:Q99KV1	-	-	comment:mint	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:AwepE58LUoN43LmBMkof6jEPNCA10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q91XU0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8376575|intact:MINT-4113108|uniprotkb:Q921W3|uniprotkb:Q8BWP6|uniprotkb:Q3TCT7|uniprotkb:Q6PDF0|uniprotkb:Q9EQL3|uniprotkb:Q8BY55|uniprotkb:Q8BUW5|ensembl:ENSMUSP00000021832	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:wrip1_mouse(display_long)|uniprotkb:Wrnip1(gene name)|psi-mi:Wrnip1(display_short)|uniprotkb:Whip(gene name synonym)|uniprotkb:Werner helicase-interacting protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_084491.3|ensembl:ENSMUSG00000021400(gene)|ensembl:ENSMUST00000021832(transcript)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR021886|interpro:IPR027417|interpro:IPR032423|interpro:IPR040539|mint:Q91XU0	-	-	comment:mint|function:Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:3cjtBXbw7X8eJ6V9tsVNsTKXXjA10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9DD18	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8319117|uniprotkb:A2ANA2|uniprotkb:Q9D013|intact:MINT-4093686|uniprotkb:Q9CRE8|uniprotkb:Q9CYL0|uniprotkb:Q9D1G4|uniprotkb:Q3TY44|ensembl:ENSMUSP00000028917	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dtd1_mouse(display_long)|uniprotkb:"Gly-tRNA(Ala) deacylase"(gene name synonym)|uniprotkb:Dtd1(gene name)|psi-mi:Dtd1(display_short)|uniprotkb:Hars2(gene name synonym)|uniprotkb:DNA-unwinding element-binding protein B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_079590.1|ensembl:ENSMUSG00000027430(gene)|ensembl:ENSMUST00000028917(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006399"(tRNA metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051500"("D-tyrosyl-tRNA(Tyr) deacylase activity")|interpro:IPR003732("D-tyrosyl-tRNA(Tyr) deacylase")|interpro:IPR023509|mint:Q9DD18	-	-	comment:mint|function:"Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine"	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:dMYZ6wMZwua1uwUcxlnAi/Wmo0810090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P47964	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8365611|intact:MINT-4132614	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl36_mouse(display_long)|uniprotkb:Rpl36(gene name)|psi-mi:Rpl36(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR038097|mint:P47964|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0045202"(synapse)|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|interpro:IPR000509(Ribosomal protein L36e)	-	-	comment:mint	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:LNDybrXOVq0igi414xuHjWUY1gg10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6PGC1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8428992|uniprotkb:Q8C9H9|uniprotkb:Q8C9B7|intact:MINT-4112300|uniprotkb:Q8BQJ4|uniprotkb:Q8BT01|ensembl:ENSMUSP00000035244	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dhx29_mouse(display_long)|uniprotkb:Dhx29(gene name)|psi-mi:Dhx29(display_short)|uniprotkb:DEAH box protein 29(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_766182.2|ensembl:ENSMUSG00000042426(gene)|ensembl:ENSMUST00000038574(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0008494"(translation activator activity)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042255"(ribosome assembly)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR034730|mint:Q6PGC1	-	-	comment:mint	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:rORkrwC6jPYK8bp9O+7RaI5e9KI10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9Z108	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8020609|intact:UNK-5561237|ensembl:ENSMUSP00000104859	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:stau1_mouse(display_long)|uniprotkb:Stau1(gene name)|psi-mi:Stau1(display_short)|uniprotkb:Stau(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035620.1|ensembl:ENSMUSG00000039536(gene)|ensembl:ENSMUST00000109236(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008298"(intracellular mRNA localization)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030425"(dendrite)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099010"(modification of postsynaptic structure)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR044475|mint:Q9Z108	-	-	comment:mint|function:"Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site"	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:9zPJq1T9MxPD12EiZZWLuRcCpTk10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q91WM1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8339684|intact:MINT-4121401|uniprotkb:Q62262|ensembl:ENSMUSP00000028279|ensembl:ENSMUSP00000072047	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:strbp_mouse(display_long)|uniprotkb:Strbp(gene name)|psi-mi:Strbp(display_short)|uniprotkb:Spnr(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_011237348.1|refseq:XP_011237349.1|refseq:NP_033287.2|refseq:XP_017172309.1|refseq:XP_017172310.1|refseq:XP_017172311.1|refseq:XP_017172312.1|ensembl:ENSMUSG00000026915(gene)|ensembl:ENSMUST00000028279(transcript)|ensembl:ENSMUST00000072186(transcript)|go:"GO:0002177"(manchette)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0007638"(mechanosensory behavior)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR030446|interpro:IPR043519|interpro:IPR044472|mint:Q91WM1	-	-	comment:mint|function:"Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth (By similarity). Binds to double-stranded DNA and RNA (By similarity). Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA (By similarity). Binds also to single-stranded poly(G) RNA (By similarity). Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA"	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:+sf/OyoCMvzDmHmCmq4Me4jWjco10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P52479	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8327299|uniprotkb:Q6ZQG9|uniprotkb:Q91VY7|uniprotkb:Q3TZB8|intact:MINT-1870263|uniprotkb:Q3U5E0|uniprotkb:Q3T9L4|uniprotkb:Q3TNN5|ensembl:ENSMUSP00000104616	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ubp10_mouse(display_long)|uniprotkb:Usp10(gene name)|psi-mi:Usp10(display_short)|uniprotkb:Ode-1(gene name synonym)|uniprotkb:Uchrp(gene name synonym)|uniprotkb:Kiaa0190(gene name synonym)|uniprotkb:Ubiquitin thioesterase 10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 10(gene name synonym)|uniprotkb:Deubiquitinating enzyme 10(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001297559.1|refseq:NP_033488.1|ensembl:ENSMUSG00000031826(gene)|ensembl:ENSMUST00000108988(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR018200|interpro:IPR028767|interpro:IPR028889|interpro:IPR038765|mint:P52479|reactome:R-MMU-5656169|reactome:R-MMU-5689880	-	-	comment:mint|function:Ubiquitin specific protease are required to remove ubiquitin from specific proteins or peptides to which ubiquitin is attached	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:tdoxBRcosuC3GGqMGB5pBKA9pKc10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99J85	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8311244|intact:MINT-4104086	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nptxr_mouse(display_long)|uniprotkb:Nptxr(gene name)|psi-mi:Nptxr(display_short)|uniprotkb:Npr(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0008029"(pentraxin receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099150"(regulation of postsynaptic specialization assembly)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR030476|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|mint:Q99J85	-	-	comment:mint	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:AWabDfkkTcL+AMgJlRt5ntbJ5WU10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:B2RR83	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8572369|ensembl:ENSMUSP00000048340|intact:MINT-8174232	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ytdc2_mouse(display_long)|uniprotkb:Keen to exit meiosis leaving testes under-populated protein(gene name synonym)|uniprotkb:YTH domain-containing protein C2(gene name synonym)|uniprotkb:Ythdc2(gene name)|psi-mi:Ythdc2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR007275(YT521-B-like protein)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031083|interpro:IPR034083|interpro:IPR036770|interpro:IPR036867|mint:B2RR83|ensembl:ENSMUSG00000034653(gene)|ensembl:ENSMUST00000037763(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007286"(spermatid development)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048599"(oocyte development)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR001374(Single-stranded nucleic acid binding R3H)|refseq:NP_001156485.1	-	-	comment:mint	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:TxNENB71AFsznI6fFqBPUX8pgdA10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q61656	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-643076|uniprotkb:E9Q105	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ddx5_mouse(display_long)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)|uniprotkb:DEAD box RNA helicase DEAD1(gene name synonym)|uniprotkb:Ddx5(gene name)|psi-mi:Ddx5(display_short)|uniprotkb:Tnz2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|reactome:R-MMU-3899300|reactome:R-MMU-72163|reactome:R-MMU-9018519|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009299"(mRNA transcription)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|dip:DIP-32293N|mint:Q61656	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:X5OQN/Gdq852njTrHnlDliAjrQY10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3U0M1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6160720|uniprotkb:Q3UU81|uniprotkb:Q69Z79|uniprotkb:Q6NS50|uniprotkb:Q8CD01|uniprotkb:Q8CFV8|uniprotkb:Q9D8R6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tppc9_mouse(display_long)|uniprotkb:Trappc9(gene name)|psi-mi:Trappc9(display_short)|uniprotkb:Kiaa1882(gene name synonym)|uniprotkb:Nibp(gene name synonym)|uniprotkb:NIK- and IKBKB-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	mint:Q3U0M1|refseq:NP_001158113.1|refseq:NP_001158114.1|refseq:NP_001158115.1|refseq:NP_083916.1|refseq:NP_850993.2|interpro:IPR013935(Transport protein Trs120)|refseq:XP_006521590.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030008"(TRAPP complex)|go:"GO:0030182"(neuron differentiation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-204005|reactome:R-MMU-8876198	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:4o6Vzu9Mu9hWN7CZ+ifMfOffaGk10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6P5U7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11568651|uniprotkb:Q8CHA7|uniprotkb:Q3UVW7|ensembl:ENSMUSP00000124712	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nwd2_mouse(display_long)|uniprotkb:Kiaa1239(gene name synonym)|uniprotkb:Leucine-rich repeat and WD repeat-containing protein KIAA1239(gene name synonym)|uniprotkb:Nwd2(gene name)|psi-mi:Nwd2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_795980.2|ensembl:ENSMUSG00000090061(gene)|ensembl:ENSMUST00000159584(transcript)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR027417|interpro:IPR036322|mint:Q6P5U7	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:SZKbZVvtYGyQw0UAMUWAz6Jl0uw10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6PFX9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11025784|uniprotkb:Q8BX62|ensembl:ENSMUSP00000033929	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tnks1_mouse(display_long)|uniprotkb:Tnks(gene name)|psi-mi:Tnks(display_short)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-1(gene name synonym)|uniprotkb:Tankyrase-1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 5(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 1(gene name synonym)|uniprotkb:Tnks1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_780300.2|ensembl:ENSMUSG00000031529(gene)|ensembl:ENSMUST00000033929(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051028"(mRNA transport)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904743"(negative regulation of telomeric DNA binding)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR028731|interpro:IPR036770|mint:Q6PFX9|rcsb pdb:3UTM|rcsb pdb:4N4T|rcsb pdb:5HKP|reactome:R-MMU-201681|reactome:R-MMU-4641257|reactome:R-MMU-5689880|reactome:R-MMU-8948751|rcsb pdb:6CF6|dip:DIP-61463N	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:0iTld3A3m3MICMz4QGogB1kk7iA10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8BXJ8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472924|ensembl:ENSMUSP00000107462|ensembl:ENSMUSP00000088271|uniprotkb:Q8BWQ7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:z385b_mouse(display_long)|uniprotkb:Znf385b(gene name)|psi-mi:Znf385b(display_short)|uniprotkb:Zfp385b(gene name synonym)|uniprotkb:Zfp533(gene name synonym)|uniprotkb:Znf533(gene name synonym)|uniprotkb:Zinc finger protein 533(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000090766(transcript)|ensembl:ENSMUST00000111831(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q8BXJ8|ensembl:ENSMUSG00000027016(gene)|refseq:NP_001106870.1|refseq:NP_001106871.1|refseq:NP_848838.2	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:3S0ofn39ep5mdFyf/lfOlFYCzmA10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q91YD3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6097113|ensembl:ENSMUSP00000022535|ensembl:ENSMUSP00000152897|uniprotkb:Q6NZE3	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dcp1a_mouse(display_long)|uniprotkb:Dcp1a(gene name)|psi-mi:Dcp1a(display_short)|uniprotkb:Mitc1(gene name synonym)|uniprotkb:Smif(gene name synonym)|uniprotkb:MAD homolog 4-interacting transcription coactivator 1(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:Transcription factor SMIF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q91YD3|reactome:R-MMU-430039|reactome:R-MMU-450385|reactome:R-MMU-450513|reactome:R-MMU-975957|ensembl:ENSMUSG00000021962(gene)|ensembl:ENSMUST00000022535(transcript)|ensembl:ENSMUST00000225196(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_598522.3	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:GNFxv657QCnGA5H6YA6nxBPFGpE10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q09XV5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-1169080|uniprotkb:Q3TV89|uniprotkb:Q5I1Z2|uniprotkb:Q6ZPM8|ensembl:ENSMUSP00000087184|ensembl:ENSMUSP00000142890	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:chd8_mouse(display_long)|uniprotkb:Chd8(gene name)|psi-mi:Chd8(display_short)|uniprotkb:Kiaa1564(gene name synonym)|uniprotkb:ATP-dependent helicase CHD8(gene name synonym)|uniprotkb:Axis duplication inhibitor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_963999.2|refseq:XP_006519539.1|ensembl:ENSMUSG00000053754(gene)|ensembl:ENSMUST00000089752(transcript)|ensembl:ENSMUST00000200169(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035176"(social behavior)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048565"(digestive tract development)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070615"|go:"GO:0071339"(MLL1 complex)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000330(SNF2-related)|interpro:IPR000953(Chromo domain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023780|interpro:IPR027417|interpro:IPR034724|interpro:IPR037259|interpro:IPR038718|mint:Q09XV5|reactome:R-MMU-3769402	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ZttrOvHiz/PMCKm+pScx4Tn1Af410090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CXW3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-767146|uniprotkb:O70140|ensembl:ENSMUSP00000014370	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cybp_mouse(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:Cacybp(gene name)|psi-mi:Cacybp(display_short)|uniprotkb:Sip(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_033916.1|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9CXW3|rcsb pdb:1YSM|rcsb pdb:2JTT|go:"GO:0044297"(cell body)|ensembl:ENSMUSG00000014226(gene)|ensembl:ENSMUST00000014370(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:lXb5K4QwSjgHuXDBSwSvGJgiV6810090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:A2RSY6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471734|uniprotkb:Q0VGB9|uniprotkb:Q3UFG1|uniprotkb:Q3UKB0|uniprotkb:Q8C2S4|uniprotkb:Q8CI50|uniprotkb:Q8R203|uniprotkb:Q9CT68	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:trm1l_mouse(display_long)|uniprotkb:Trmt1l(gene name)|psi-mi:Trmt1l(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0000049"(tRNA binding)|go:"GO:0002940"(tRNA N2-guanine methylation)|go:"GO:0004809"("tRNA (guanine-N2-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0030534"(adult behavior)|go:"GO:0046872"(metal ion binding)|mint:A2RSY6|refseq:NP_081152.2|interpro:IPR029063|interpro:IPR002905(N2,N2-dimethylguanosine tRNA methyltransferase)|interpro:IPR042296|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:kZky6wGrlfi/HQFN9ZEkxXltNt010090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O08532	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-770939|uniprotkb:O08533|uniprotkb:O08534|uniprotkb:O08535|uniprotkb:O08536|ensembl:ENSMUSP00000049457	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ca2d1_mouse(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha-2/delta-1(gene name synonym)|uniprotkb:Cacna2d1(gene name)|psi-mi:Cacna2d1(display_short)|uniprotkb:Cacna2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001104313.1|refseq:NP_001104314.1|refseq:NP_001104315.1|refseq:NP_001104316.1|refseq:NP_033914.1|ensembl:ENSMUSG00000040118(gene)|ensembl:ENSMUST00000039370(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030315"(T-tubule)|go:"GO:0046872"(metal ion binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086048"(membrane depolarization during bundle of His cell action potential)|go:"GO:0086057"(voltage-gated calcium channel activity involved in bundle of His cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099025"(anchored component of postsynaptic membrane)|go:"GO:0099029"(anchored component of presynaptic active zone membrane)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1901843"(positive regulation of high voltage-gated calcium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013608(VWA N-terminal)|interpro:IPR013680(Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region)|interpro:IPR036465|mint:O08532	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:fY8StGDMVTfTBrs3lV7rYVrjvBg10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P61979	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-299907|ensembl:ENSMUSP00000039269|uniprotkb:Q07244|uniprotkb:Q15671|uniprotkb:Q60577|uniprotkb:Q8BGQ8|uniprotkb:Q922Y7|uniprotkb:Q96J62	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:hnrpk_mouse(display_long)|uniprotkb:Hnrnpk(gene name)|psi-mi:Hnrnpk(display_short)|uniprotkb:Hnrpk(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000043269(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0002102"(podosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|ensembl:ENSMUSG00000021546(gene)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1990715"(mRNA CDS binding)|go:"GO:1990829"(C-rich single-stranded DNA binding)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000173"(negative regulation of branching morphogenesis of a nerve)|interpro:IPR004087(K Homology)|go:"GO:0051117"(ATPase binding)|go:"GO:0060999"(positive regulation of dendritic spine development)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012987(ROK, N-terminal)|interpro:IPR033090|interpro:IPR036612|mint:P61979|reactome:R-MMU-4570464|reactome:R-MMU-72163|reactome:R-MMU-72203|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902165"(regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904322"(cellular response to forskolin)|refseq:NP_001288269.1|refseq:NP_001288270.1|refseq:NP_001288272.1|refseq:NP_001288273.1|refseq:NP_001288274.1|refseq:XP_017170884.1|refseq:XP_017170885.1|refseq:NP_079555.1|refseq:XP_006517166.1|refseq:XP_006517167.1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:YZQD5JJkHPUMtZ4XUA9fQkNfXzc10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9R1K9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2553037|ensembl:ENSMUSP00000110198|uniprotkb:Q3UBB4|uniprotkb:B1AUQ8|uniprotkb:B1AUQ6|uniprotkb:Q9CWM0	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cetn2_mouse(display_long)|uniprotkb:Cetn2(gene name)|psi-mi:Cetn2(display_short)|uniprotkb:Calt(gene name synonym)|uniprotkb:Caltractin isoform 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000031347(gene)|ensembl:ENSMUST00000114551(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005929"(cilium)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007099"(centriole replication)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045177"(apical part of cell)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|go:"GO:0070390"(transcription export complex 2)|go:"GO:0071942"(XPC complex)|go:"GO:0097729"(9+2 motile cilium)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR037629|mint:Q9R1K9|reactome:R-MMU-2565942|reactome:R-MMU-3108214|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5696394|reactome:R-MMU-5696395|reactome:R-MMU-8854518|reactome:R-MMU-380284|refseq:NP_062278.2	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:XCnoVczmFNVZ2uiS+EyVanW/VMw10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80X66	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471043|ensembl:ENSMUSP00000048530	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:btbda_mouse(display_long)|uniprotkb:Btbd10(gene name)|psi-mi:Btbd10(display_short)|uniprotkb:Gmrp1(gene name synonym)|uniprotkb:Glucose metabolism-related protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR011333(BTB/POZ fold)|interpro:IPR039885|interpro:IPR039886|mint:Q80X66|ensembl:ENSMUSG00000038187(gene)|ensembl:ENSMUST00000047091(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR000210(BTB/POZ-like)|refseq:NP_598461.1|refseq:XP_006508223.1|refseq:XP_011240192.1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:VoTwPedMCjTuxDWUH5cbm1iIUQ410090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8C854	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-4285350|uniprotkb:Q6ZPT3|uniprotkb:Q8QZZ1|uniprotkb:Q60690|uniprotkb:Q6P930|ensembl:ENSMUSP00000123088	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:myef2_mouse(display_long)|uniprotkb:Myef2(gene name)|psi-mi:Myef2(display_short)|uniprotkb:Kiaa1341(gene name synonym)|uniprotkb:Mef2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001155889.1|refseq:XP_006498947.1|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034630|interpro:IPR034631|interpro:IPR034632|interpro:IPR035979|interpro:IPR000504(RNA recognition motif, RNP-1)|mint:Q8C854|ensembl:ENSMUSG00000027201(gene)|ensembl:ENSMUST00000152367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000815"(regulation of mRNA stability involved in response to oxidative stress)|refseq:XP_017171620.1|refseq:XP_017171621.1|refseq:XP_017171623.1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ZnM8NqQUhlLdO7gzhs09ckrZUPw10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q920Q4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-775797|uniprotkb:A2BI91|uniprotkb:Q8R3C3|uniprotkb:Q99KZ4	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:vps16_mouse(display_long)|uniprotkb:Vps16(gene name)|psi-mi:Vps16(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR016534(Vacuolar protein sorting-associated protein 16)|interpro:IPR006925(Vps16, C-terminal)|interpro:IPR006926(Vps16, N-terminal)|interpro:IPR038132|mint:Q920Q4|go:"GO:0003779"(actin binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005884"(actin filament)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030424"(axon)|go:"GO:0030897"(HOPS complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033263"(CORVET complex)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051015"(actin filament binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0097352"(autophagosome maturation)	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:7XQzmHj2pjKXXSGR6yOyO+cUjfg10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CJF9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-9030886|uniprotkb:Q3TBP7|ensembl:ENSMUSP00000066633	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ago3_mouse(display_long)|uniprotkb:Ago3(gene name)|psi-mi:Ago3(display_short)|uniprotkb:Eif2c3(gene name synonym)|uniprotkb:Argonaute RISC catalytic component 3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 3(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_700451.2|ensembl:ENSMUSG00000028842(gene)|ensembl:ENSMUST00000069097(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0046872"(metal ion binding)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028603|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJF9|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:JBJer7uFfQamp+D9D7xPSd0iPuo10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9R0N8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-5239378|uniprotkb:E9QJV2|uniprotkb:Q9QUK7|ensembl:ENSMUSP00000088196|ensembl:ENSMUSP00000112997	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:syt6_mouse(display_long)|uniprotkb:Syt6(gene name)|psi-mi:Syt6(display_short)|uniprotkb:Synaptotagmin VI(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_061270.2|ensembl:ENSMUSG00000027849(gene)|ensembl:ENSMUST00000090697(transcript)|ensembl:ENSMUST00000121834(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007340"(acrosome reaction)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099525"(presynaptic dense core vesicle exocytosis)|go:"GO:0099699"(integral component of synaptic membrane)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR028701|interpro:IPR035892|mint:Q9R0N8	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:6zuc3c/rwhfoVuG05EW4OP4SHDc10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:E9Q8I9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16732044|ensembl:ENSMUSP00000084454|uniprotkb:Q4VA57|uniprotkb:Q5DTL4|uniprotkb:Q8BIW6|uniprotkb:Q8BUA0|uniprotkb:Q8CG91	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:fry_mouse(display_long)|uniprotkb:Fry(gene name)|psi-mi:Fry(display_short)|uniprotkb:Kiaa4143(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000056602(gene)|ensembl:ENSMUST00000087204(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005938"(cell cortex)|go:"GO:0030427"(site of polarized growth)|go:"GO:0031175"(neuron projection development)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025481|interpro:IPR025614|interpro:IPR029473|interpro:IPR039867|mint:E9Q8I9|refseq:NP_766475.2|refseq:XP_006504993.1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:fvduzhqkwcM9qmnWvPWAA1W8HqI10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80VC9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2125556|uniprotkb:Q5DTW9|uniprotkb:Q8BUZ0|uniprotkb:E9Q5B0|uniprotkb:U5LGR7|uniprotkb:U5LGS1|uniprotkb:U5LGS5|uniprotkb:U5LGT0|uniprotkb:U5LHT8|uniprotkb:U5LHU4|uniprotkb:U5LHW1|uniprotkb:U5LHW4|uniprotkb:U5LHW9|uniprotkb:U5LK15|uniprotkb:U5LK19|uniprotkb:U5LK24|uniprotkb:U5LK70|uniprotkb:U5LK74|uniprotkb:U5LK79|ensembl:ENSMUSP00000058958	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:camp3_mouse(display_long)|uniprotkb:Marshalin(gene name synonym)|uniprotkb:Camsap3(gene name)|psi-mi:Camsap3(display_short)|uniprotkb:Protein Nezha(gene name synonym)|uniprotkb:Kiaa1543(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001157221.1|refseq:NP_081447.2|dip:DIP-52404N|refseq:NP_001334040.1|refseq:NP_001334041.1|refseq:NP_001334042.1|refseq:XP_006508937.1|refseq:XP_006508939.1|refseq:XP_006508941.1|ensembl:ENSMUSG00000044433(gene)|ensembl:ENSMUST00000057028(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003341"(cilium movement)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005915"(zonula adherens)|go:"GO:0005930"(axoneme)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030507"(spectrin binding)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031514"(motile cilium)|go:"GO:0033043"(regulation of organelle organization)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0036064"(ciliary basal body)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045218"(zonula adherens maintenance)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:1903358"(regulation of Golgi organization)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011033(PRC-barrel-like)|interpro:IPR014797(Protein of unknown function DUF1781)|interpro:IPR022613|interpro:IPR031372|interpro:IPR032940|interpro:IPR036872|interpro:IPR038209|mint:Q80VC9|rcsb pdb:1UGJ|rcsb pdb:5LZN|rcsb pdb:5M50|rcsb pdb:5OW5	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Z30CkFi9SutmAZxuqpznPko7qZw10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3UFQ8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-13951462|ensembl:ENSMUSP00000075587|uniprotkb:Q6KAP3	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:carl3_mouse(display_long)|uniprotkb:Carmil3(gene name)|psi-mi:Carmil3(display_short)|uniprotkb:Lrrc16b(gene name synonym)|uniprotkb:Capping protein regulator and myosin 1 linker protein 3(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 16B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000022211(gene)|ensembl:ENSMUST00000076236(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029766|interpro:IPR031943|interpro:IPR032675|interpro:IPR041245|mint:Q3UFQ8|refseq:NP_001019816.1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:gPESbxfNq/mOFgUYRM0Yw83jUYk10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O70133	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2657677|uniprotkb:O35931|uniprotkb:O54703|uniprotkb:Q5FWY1|uniprotkb:Q6R5F7|uniprotkb:Q9CSA2	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dhx9_mouse(display_long)|uniprotkb:Dhx9(gene name)|psi-mi:Dhx9(display_short)|uniprotkb:Ddx9(gene name synonym)|uniprotkb:Nuclear DNA helicase II(gene name synonym)|uniprotkb:DEAH box protein 9(gene name synonym)|uniprotkb:RNA helicase A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_031868.2|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR007502(Helicase-associated region)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001069"(regulatory region RNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005844"(polysome)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007623"(circadian rhythm)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016442"(RISC complex)|go:"GO:0016604"(nuclear body)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033679"(3'-5' DNA/RNA helicase activity)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045142"(triplex DNA binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0047429"(nucleoside-triphosphate diphosphatase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070269"(pyroptosis)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904973"(positive regulation of viral translation)|go:"GO:1905172"(RISC complex binding)|go:"GO:1905538"(polysome binding)|go:"GO:1905698"(positive regulation of polysome binding)|go:"GO:1990518"(single-stranded 3'-5' DNA helicase activity)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000765"(regulation of cytoplasmic translation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|rcsb pdb:1UIL|rcsb pdb:1WHQ|rcsb pdb:2RS6|rcsb pdb:2RS7|reactome:R-MMU-1810476|reactome:R-MMU-3134963|reactome:R-MMU-72163|interpro:IPR027417|mint:O70133|interpro:IPR044445|interpro:IPR044446|interpro:IPR044447	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:8NHxvbw0StglewhGm3e7Pi/8oOg10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TSC1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-645425|uniprotkb:Q923A9|uniprotkb:Q9Z1R1|ensembl:ENSMUSP00000025253	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:prc2a_mouse(display_long)|uniprotkb:HLA-B-associated transcript 2(gene name synonym)|uniprotkb:Prrc2a(gene name)|psi-mi:Prrc2a(display_short)|uniprotkb:Bat2(gene name synonym)|uniprotkb:Proline-rich and coiled-coil-containing protein 2A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001185973.1|refseq:NP_064411.2|refseq:XP_006524683.1|dip:DIP-49629N|ensembl:ENSMUSG00000024393(gene)|ensembl:ENSMUST00000025253(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030154"(cell differentiation)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:Q7TSC1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ktwyGkClOoaD4rZap/xJb/aKj4s10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9EPU0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6876715|ensembl:ENSMUSP00000075089|uniprotkb:Q3UG00|uniprotkb:Q6GYP5|uniprotkb:Q6PHQ5|uniprotkb:Q8K0N4|uniprotkb:Q99PR4	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rent1_mouse(display_long)|uniprotkb:Upf1(gene name)|psi-mi:Upf1(display_short)|uniprotkb:Rent1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000058301(gene)|ensembl:ENSMUST00000075666(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016787"(hydrolase activity)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR018999|interpro:IPR027417|interpro:IPR040812|interpro:IPR041677|interpro:IPR041679|mint:Q9EPU0|reactome:R-MMU-975956|reactome:R-MMU-975957|go:"GO:0042162"(telomeric DNA binding)|refseq:XP_006509667.1|refseq:XP_006509668.1|refseq:NP_001116301.1|refseq:NP_109605.2|dip:DIP-60114N	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:rwd4XXdf5Uqjtgao/zILckKP8AM10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P09541	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-20567045	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:myl4_mouse(display_long)|uniprotkb:MLC1EMB(gene name synonym)|uniprotkb:Myosin light chain 1, atrial/fetal isoform(gene name synonym)|uniprotkb:Myl4(gene name)|psi-mi:Myl4(display_short)|uniprotkb:Mlc1a(gene name synonym)|uniprotkb:Myla(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016459"(myosin complex)|go:"GO:0031672"(A band)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0060048"(cardiac muscle contraction)|reactome:R-MMU-390522|interpro:IPR011992(EF-Hand type)|interpro:IPR002048(Calcium-binding EF-hand)|mint:P09541	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:aD1Fs+tY7Wxoc2RdDx2+vXHvI3Q10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99JB8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-77834|ensembl:ENSMUSP00000028694|ensembl:ENSMUSP00000054391|ensembl:ENSMUSP00000106981|ensembl:ENSMUSP00000129175|uniprotkb:Q9EQP9	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:pacn3_mouse(display_long)|uniprotkb:Pacsin3(gene name)|psi-mi:Pacsin3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000027257(gene)|ensembl:ENSMUST00000028694(transcript)|ensembl:ENSMUST00000059566(transcript)|ensembl:ENSMUST00000111349(transcript)|ensembl:ENSMUST00000168916(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008289"(lipid binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR028523|interpro:IPR031160|interpro:IPR036028|mint:Q99JB8|rcsb pdb:3M3W|rcsb pdb:3QE6|rcsb pdb:3SYV|reactome:R-MMU-8856828|refseq:NP_083009.1|refseq:NP_112019.2|refseq:XP_006500487.1|refseq:XP_006500488.1|refseq:XP_006500490.1|refseq:XP_006500491.1|refseq:NP_001276606.1|refseq:NP_001276607.1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:cm01D0WJAwAupYJ64NRxTeFC79U10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6VH22	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-22226681|ensembl:ENSMUSP00000049335|uniprotkb:Q6NZK1|uniprotkb:Q80TI4|uniprotkb:Q80W19|uniprotkb:Q9DAB0	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:if172_mouse(display_long)|uniprotkb:Ift172(gene name)|psi-mi:Ift172(display_short)|uniprotkb:Kiaa1179(gene name synonym)|uniprotkb:Wim(gene name synonym)|uniprotkb:Protein wimple(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0060271"(cilium assembly)|go:"GO:0060348"(bone development)|go:"GO:0061525"(hindgut development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097228"(sperm principal piece)|go:"GO:0097598"(sperm cytoplasmic droplet)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR036322|mint:Q6VH22|reactome:R-MMU-5610787|reactome:R-MMU-5620924|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008544"(epidermis development)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021915"(neural tube development)|go:"GO:0030992"(intraciliary transport particle B)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031514"(motile cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060173"(limb development)|go:"GO:0007368"(determination of left/right symmetry)|ensembl:ENSMUSG00000038564(gene)|ensembl:ENSMUST00000041565(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001841"(neural tube formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|refseq:NP_080574.5	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:qKlWtm735I1OrvYPmj7ZUyI3ZDA10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8C5W0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-774379|uniprotkb:Q91V71|uniprotkb:Q91XT7|uniprotkb:Q91XT8|uniprotkb:Q91XU9|ensembl:ENSMUSP00000105563	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:clmn_mouse(display_long)|uniprotkb:Calponin-like transmembrane domain protein(gene name synonym)|uniprotkb:Clmn(gene name)|psi-mi:Clmn(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001035772.1|refseq:NP_444385.2|ensembl:ENSMUSG00000021097(gene)|ensembl:ENSMUST00000109937(transcript)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0007097"(nuclear migration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0051015"(actin filament binding)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR036872|mint:Q8C5W0	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:+QifozWRqE6NppDc+GPs9Jsm/uQ10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q61687	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2657527|intact:EBI-2658449|uniprotkb:A2ADH4|ensembl:ENSMUSP00000109203	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:atrx_mouse(display_long)|uniprotkb:Xnp(gene name synonym)|uniprotkb:ATP-dependent helicase ATRX(gene name synonym)|uniprotkb:HP1 alpha-interacting protein(gene name synonym)|uniprotkb:HP1-BP38 protein(gene name synonym)|uniprotkb:Heterochromatin protein 2(gene name synonym)|uniprotkb:X-linked nuclear protein(gene name synonym)|uniprotkb:Atrx(gene name)|psi-mi:Atrx(display_short)|uniprotkb:Hp1bp2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_033556.2|interpro:IPR038718|interpro:IPR041430|mint:Q61687|reactome:R-MMU-9670095|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900112"(regulation of histone H3-K9 trimethylation)|go:"GO:1901581"(negative regulation of telomeric RNA transcription from RNA pol II promoter)|go:"GO:1901582"(positive regulation of telomeric RNA transcription from RNA pol II promoter)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR025766|interpro:IPR027417|ensembl:ENSMUSG00000031229(gene)|ensembl:ENSMUST00000113573(transcript)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)|go:"GO:0015616"(DNA translocase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030900"(forebrain development)|go:"GO:0031297"(replication fork processing)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035128"(post-embryonic forelimb morphogenesis)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070615"|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0072711"(cellular response to hydroxyurea)|dip:DIP-55974N	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:dZfE7Or8WAgkuHkmUcqC3UlWi7U10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CQ10	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2554069|uniprotkb:Q9D7A5|uniprotkb:Q9D2Z2|ensembl:ENSMUSP00000068410|ensembl:ENSMUSP00000109815	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:chmp3_mouse(display_long)|uniprotkb:Chmp3(gene name)|psi-mi:Chmp3(display_short)|uniprotkb:Chromatin-modifying protein 3(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 24(gene name synonym)|uniprotkb:Vps24(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080059.2|ensembl:ENSMUSG00000053119(gene)|ensembl:ENSMUST00000059462(transcript)|ensembl:ENSMUST00000065364(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0030496"(midbody)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:0031902"(late endosome membrane)|interpro:IPR005024(Snf7)|go:"GO:0032467"(positive regulation of cytokinesis)|mint:Q9CQ10|reactome:R-MMU-1632852|reactome:R-MMU-5620971|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|reactome:R-MMU-917729|reactome:R-MMU-9668328|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051258"(protein polymerization)|go:"GO:0061763"(multivesicular body-lysosome fusion)|go:"GO:0061952"(midbody abscission)|go:"GO:1902187"	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:b52oV5XLyniABacZtbbmaLqKd3M10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q0KL02	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16725543|uniprotkb:Q3U522|uniprotkb:Q6P9K6|uniprotkb:Q80W23	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:trio_mouse(display_long)|uniprotkb:Trio(gene name)|psi-mi:Trio(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0019899"(enzyme binding)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-MMU-193648|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-418885|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013423|mint:Q0KL02|refseq:NP_001074771.1|refseq:XP_006520117.1|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR036865|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|interpro:IPR028570	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:nUVpjuymw6gIq+G/H2xcZJh55a810090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O55017	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-770881|uniprotkb:Q60609|ensembl:ENSMUSP00000037416	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cac1b_mouse(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide isoform 5(gene name synonym)|uniprotkb:Brain calcium channel III(gene name synonym)|uniprotkb:Cacna1b(gene name)|psi-mi:Cacna1b(display_short)|uniprotkb:Cach5(gene name synonym)|uniprotkb:Cacnl1a5(gene name synonym)|uniprotkb:Cchn1a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001035993.1|ensembl:ENSMUSG00000004113(gene)|ensembl:ENSMUST00000041342(transcript)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033574"(response to testosterone)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0048265"(response to pain)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:1904645"(response to amyloid-beta)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005447(Voltage-dependent calcium channel, N-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR043203|mint:O55017|reactome:R-MMU-112308	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:yTkuOwWJbxQkfOPg/TA8cPvpH+Q10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:A2CG49	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-770321|uniprotkb:A2CG50|uniprotkb:A2CG51|uniprotkb:A2CG52|uniprotkb:A2CG53|uniprotkb:Q3TYL1|uniprotkb:Q3UTA5|uniprotkb:Q8BTT9|uniprotkb:Q8C4Q2|uniprotkb:Q9CVA9|uniprotkb:Q3TXY8|uniprotkb:B2RXR5|uniprotkb:D3Z559|ensembl:ENSMUSP00000076088	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kalrn_mouse(display_long)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001157740.1|refseq:XP_006522445.1|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000719(Protein kinase, core)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018159|interpro:IPR028570|interpro:IPR035899|interpro:IPR036028|interpro:IPR036116|interpro:IPR036179|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSMUSG00000061751(gene)|ensembl:ENSMUST00000076810(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019899"(enzyme binding)|go:"GO:0035176"(social behavior)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042711"(maternal behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0046959"(habituation)|mint:A2CG49|rcsb pdb:1WFW|reactome:R-MMU-193648|reactome:R-MMU-3928662|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5687128|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013408|interpro:IPR036865	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:pDqdA2QNbqgLE3eYQXVVW2cxIyo10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O70589	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-771402|uniprotkb:A2ADP8|uniprotkb:A2ADP9|uniprotkb:A2ADQ4|uniprotkb:O70588|uniprotkb:Q3UW92	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cskp_mouse(display_long)|uniprotkb:Calcium/calmodulin-dependent serine protein kinase(gene name synonym)|uniprotkb:Cask(gene name)|psi-mi:Cask(display_short)|uniprotkb:Lin-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001271432.1|refseq:NP_001271433.1|refseq:NP_001271434.1|refseq:NP_033936.2|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR011009(Protein kinase-like)|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:O70589|go:"GO:0060170"(ciliary membrane)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070509"(calcium ion import)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097440"(apical dendrite)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098846"(podocyte foot)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|rcsb pdb:1Y74|rcsb pdb:6Y9O|reactome:R-MMU-212676|reactome:R-MMU-6794361|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031982"(vesicle)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:3co6JdI4q/n5C8zGb5JYFL2t7pc10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q5XJV6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16726286|uniprotkb:A6BLZ0|uniprotkb:Q52KF1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:lmtk3_mouse(display_long)|uniprotkb:Apoptosis-associated tyrosine kinase 3(gene name synonym)|uniprotkb:Lemur tyrosine kinase 3(gene name synonym)|uniprotkb:Lmtk3(gene name)|psi-mi:Lmtk3(display_short)|uniprotkb:Aatyk3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|mint:Q5XJV6|refseq:NP_001005511.2|refseq:NP_001277919.1|refseq:XP_006541027.1|refseq:XP_017177816.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:FJgk1CZB0wgIbl5dhC81Wy7TRJE10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9D6G9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470970|ensembl:ENSMUSP00000036138|uniprotkb:Q9DB66	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cklf5_mouse(display_long)|uniprotkb:Cmtm5(gene name)|psi-mi:Cmtm5(display_short)|uniprotkb:Cklfsf5(gene name synonym)|uniprotkb:Chemokine-like factor superfamily member 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000040759(gene)|ensembl:ENSMUST00000037814(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045662"(negative regulation of myoblast differentiation)|interpro:IPR008253(Marvel)|mint:Q9D6G9|refseq:NP_080342.1|refseq:XP_017171651.1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Kj8DRGtMwsoKRnanvRkfzDr+4J810090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8C419	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-776313|uniprotkb:B1AWY4|uniprotkb:Q8CHB0|ensembl:ENSMUSP00000049708	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:gp158_mouse(display_long)|uniprotkb:Gpr158(gene name)|psi-mi:Gpr158(display_short)|uniprotkb:Kiaa1136(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001004761.1|ensembl:ENSMUSG00000045967(gene)|ensembl:ENSMUST00000055946(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR017978|interpro:IPR043458|mint:Q8C419	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:lQ1QK/rThy3Oe3+avASjFcYuFTI10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:D3YXK2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-539539|ensembl:ENSMUSP00000092849	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:safb1_mouse(display_long)|uniprotkb:Safb(gene name)|psi-mi:Safb(display_short)|uniprotkb:Safb1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001156772.1|ensembl:ENSMUST00000095224(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030496"(midbody)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0040008"(regulation of growth)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050684"(regulation of mRNA processing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034781|interpro:IPR035979|interpro:IPR036361|mint:D3YXK2|ensembl:ENSMUSG00000071054(gene)|reactome:R-MMU-3899300	-	-	comment:Author screened murine library then identified protein by homology to rat. Currently no murine sequence in database.	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:wGs3hvKUEDoWR83eBl9+qv4JWzs10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8VH51	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-644098|uniprotkb:Q5RJI0|uniprotkb:Q99KV0|ensembl:ENSMUSP00000105216	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rbm39_mouse(display_long)|uniprotkb:RNA-binding motif protein 39(gene name synonym)|uniprotkb:RNA-binding region-containing protein 2(gene name synonym)|uniprotkb:Coactivator of activating protein 1 and estrogen receptors(gene name synonym)|uniprotkb:Rbm39(gene name)|psi-mi:Rbm39(display_short)|uniprotkb:Caper(gene name synonym)|uniprotkb:Rnpc2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_573505.2|ensembl:ENSMUSG00000027620(gene)|ensembl:ENSMUST00000109587(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016607"(nuclear speck)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050733"(RS domain binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006509(Splicing factor, CC1-like)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR029123|interpro:IPR035979|mint:Q8VH51|rcsb pdb:2LQ5|rcsb pdb:3S6E|rcsb pdb:4J5O|rcsb pdb:4RU2|rcsb pdb:5CXT|refseq:XP_011237629.1|refseq:NP_001278043.1|refseq:NP_001278044.1|refseq:XP_017171483.1|refseq:XP_017171494.1|refseq:XP_017171497.1|refseq:XP_011237628.1|refseq:XP_017171487.1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:dW5PuXllczFeyQ6ask6CFrukMKk10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q5F2E7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11567759|uniprotkb:Q80TF1|uniprotkb:Q3V195|uniprotkb:Q3TCE2|ensembl:ENSMUSP00000098365	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nufp2_mouse(display_long)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:Kiaa1321(gene name synonym)|uniprotkb:Nufip2(gene name)|psi-mi:Nufip2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001019376.1|refseq:XP_006534125.1|ensembl:ENSMUSG00000037857(gene)|ensembl:ENSMUST00000100802(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q5F2E7	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:rckz1rTUY3/RppScoXLaw1Z9ipU10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O35681	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-457995|uniprotkb:P97791|uniprotkb:Q80WV1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:syt3_mouse(display_long)|uniprotkb:Syt3(gene name)|psi-mi:Syt3(display_short)|uniprotkb:Synaptotagmin III(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001107588.1|refseq:NP_057872.3|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR028682|mint:O35681|interpro:IPR035892	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:mkfffZn3WWGhztw/udRiKd0LUJ010090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9JIK5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2551674|uniprotkb:Q3TVJ3|ensembl:ENSMUSP00000042691|uniprotkb:Q9WV45	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ddx21_mouse(display_long)|uniprotkb:Nucleolar RNA helicase II(gene name synonym)|uniprotkb:Nucleolar RNA helicase Gu(gene name synonym)|uniprotkb:RH II/Gu(gene name synonym)|uniprotkb:Gu-alpha(gene name synonym)|uniprotkb:DEAD box protein 21(gene name synonym)|uniprotkb:Ddx21(gene name)|psi-mi:Ddx21(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000020075(gene)|ensembl:ENSMUST00000045866(transcript)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0019843"(rRNA binding)|go:"GO:0030515"(snoRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0062176"(R-loop disassembly)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012562(GUCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR035979|mint:Q9JIK5|rcsb pdb:3ZIN|reactome:R-MMU-5250924|reactome:R-MMU-6791226|go:"GO:0051607"(defense response to virus)|refseq:NP_062426.2|dip:DIP-48574N	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:VMHd6Qxsw72ljg+FE39/O559ynI10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P70398	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2214043|uniprotkb:E9QLY0|uniprotkb:Q62497	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:usp9x_mouse(display_long)|uniprotkb:Ubiquitin thioesterase FAF-X(gene name synonym)|uniprotkb:Usp9x(gene name)|psi-mi:Usp9x(display_short)|uniprotkb:Fafl(gene name synonym)|uniprotkb:Fam(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease FAF-X(gene name synonym)|uniprotkb:Deubiquitinating enzyme FAF-X(gene name synonym)|uniprotkb:Fat facets protein-related, X-linked(gene name synonym)|uniprotkb:Ubiquitin-specific protease 9, X chromosome(gene name synonym)|uniprotkb:Ubiquitin carboxyl-terminal hydrolase FAM(gene name synonym)|uniprotkb:Fat facets homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR016024(Armadillo-type fold)|interpro:IPR028889|refseq:NP_033507.2|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:P70398|interpro:IPR038765|interpro:IPR021905|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021698"(cerebellar cortex structural organization)|go:"GO:0021766"(hippocampus development)|go:"GO:0030426"(growth cone)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045177"(apical part of cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|reactome:R-MMU-2173795|reactome:R-MMU-5689880|reactome:R-MMU-8866652|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-9033241	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:QXx5gkd+PxoNgIj2b2dLjpCuNr410090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9WTU3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6396042|uniprotkb:Q3TYI3|uniprotkb:Q60828|uniprotkb:Q60858|uniprotkb:Q62449	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:scn8a_mouse(display_long)|uniprotkb:Scn8a(gene name)|psi-mi:Scn8a(display_short)|uniprotkb:Nbna1(gene name synonym)|uniprotkb:Sodium channel protein type VIII subunit alpha(gene name synonym)|uniprotkb:Voltage-gated sodium channel subunit alpha Nav1.6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0001518"(voltage-gated sodium channel complex)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007517"(muscle organ development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031402"(sodium ion binding)|go:"GO:0033268"(node of Ranvier)|go:"GO:0034706"(sodium channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043194"(axon initial segment)|go:"GO:0050905"(neuromuscular process)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|rcsb pdb:3WFN|reactome:R-MMU-5576892|mint:Q9WTU3|interpro:IPR044564|interpro:IPR027359|interpro:IPR024583|interpro:IPR005821(Ion transport)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR008054(Na+ channel 8)|interpro:IPR001696(Na+ channel)|interpro:IPR010526(Sodium ion transport-associated)|refseq:NP_001070967.1|refseq:NP_035453.2|interpro:IPR043203	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:unNA0jT1D+rVCXv6xsuveXffeHg10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P11881	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-541478|uniprotkb:P20943|uniprotkb:Q99LG5|ensembl:ENSMUSP00000032192	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:itpr1_mouse(display_long)|uniprotkb:Type 1 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 1(gene name synonym)|uniprotkb:Inositol 1,4,5-trisphosphate-binding protein P400(gene name synonym)|uniprotkb:Purkinje cell protein 1(gene name synonym)|uniprotkb:Protein PCD-6(gene name synonym)|uniprotkb:Itpr1(gene name)|psi-mi:Itpr1(display_short)|uniprotkb:Insp3r(gene name synonym)|uniprotkb:Pcd6(gene name synonym)|uniprotkb:Pcp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_034715.3|refseq:XP_006505693.1|refseq:XP_006505699.1|refseq:XP_006505700.1|dip:DIP-32243N|refseq:XP_017176897.1|refseq:XP_017176899.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0098794"(postsynapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|mint:P11881|rcsb pdb:1N4K|rcsb pdb:1XZZ|rcsb pdb:5GUG|rcsb pdb:5X9Z|rcsb pdb:5XA0|rcsb pdb:5XA1|reactome:R-MMU-114508|reactome:R-MMU-139853|reactome:R-MMU-381676|reactome:R-MMU-418457|reactome:R-MMU-5578775|reactome:R-MMU-983695|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097421"(liver regeneration)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098695"(inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels)|go:"GO:0098793"(presynapse)|ensembl:ENSMUSG00000030102(gene)|ensembl:ENSMUST00000032192(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:O+LA4/Acwos+RNtyqL3IgAe/kkk10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TMK9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2735641|uniprotkb:O88991|uniprotkb:Q2YDV8|uniprotkb:Q68ED6|uniprotkb:Q80YV6|uniprotkb:Q8BGP1|uniprotkb:Q8C5K6|uniprotkb:Q8CGC2|uniprotkb:Q91ZR0|uniprotkb:Q99KU9|uniprotkb:Q9QYF4|ensembl:ENSMUSP00000133649	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:hnrpq_mouse(display_long)|uniprotkb:Syncrip(gene name)|psi-mi:Syncrip(display_short)|uniprotkb:Hnrpq(gene name synonym)|uniprotkb:Nsap1(gene name synonym)|uniprotkb:Nsap1l(gene name synonym)|uniprotkb:Synaptotagmin-binding, cytoplasmic RNA-interacting protein(gene name synonym)|uniprotkb:Glycine- and tyrosine-rich RNA-binding protein(gene name synonym)|uniprotkb:NS1-associated protein 1(gene name synonym)|uniprotkb:pp68(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001271257.1|refseq:NP_062640.2|refseq:NP_062770.1|refseq:NP_001298042.1|ensembl:ENSMUSG00000032423(gene)|ensembl:ENSMUST00000173801(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006397"(mRNA processing)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006535(HnRNP R and Q splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034544|interpro:IPR034548|interpro:IPR035979|interpro:IPR041337|mint:Q7TMK9	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Ljuz8koebOL7L9jFBaevQYHinzw10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99JY8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-773683|uniprotkb:Q3TVM4|uniprotkb:Q3TXR7|uniprotkb:Q8BTB7|ensembl:ENSMUSP00000065719	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:plpp3_mouse(display_long)|uniprotkb:Plpp3(gene name)|psi-mi:Plpp3(display_short)|uniprotkb:Lipid phosphate phosphohydrolase 3(gene name synonym)|uniprotkb:Lpp3(gene name synonym)|uniprotkb:PAP2-beta(gene name synonym)|uniprotkb:Phosphatidate phosphohydrolase type 2b(gene name synonym)|uniprotkb:Phosphatidic acid phosphatase 2b(gene name synonym)|uniprotkb:Ppap2b(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_542122.1|ensembl:ENSMUSG00000028517(gene)|ensembl:ENSMUST00000064139(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001568"(blood vessel development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005178"(integrin binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006670"(sphingosine metabolic process)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008195"(phosphatidate phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042392"(sphingosine-1-phosphate phosphatase activity)|go:"GO:0042577"(lipid phosphatase activity)|go:"GO:0044328"(canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration)|go:"GO:0044329"(canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion)|go:"GO:0044330"(canonical Wnt signaling pathway involved in positive regulation of wound healing)|go:"GO:0045121"(membrane raft)|go:"GO:0046839"(phospholipid dephosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0106235"(ceramide-1-phosphate phosphatase activity)|go:"GO:1902068"(regulation of sphingolipid mediated signaling pathway)|interpro:IPR000326(Phosphatidic acid phosphatase type 2/haloperoxidase)|interpro:IPR028675|interpro:IPR036938|interpro:IPR043216|mint:Q99JY8|reactome:R-MMU-1660661	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:k0j2BFjYFftNCFSr6/PrQfurHck10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3UHK6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-773013|uniprotkb:O70465|uniprotkb:Q3TSI0|uniprotkb:Q3UH52|uniprotkb:Q80TF5|uniprotkb:Q9WTS7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ten4_mouse(display_long)|uniprotkb:Tenm4(gene name)|psi-mi:Tenm4(display_short)|uniprotkb:Doc4(gene name synonym)|uniprotkb:Downstream of CHOP4(gene name synonym)|uniprotkb:Kiaa1302(gene name synonym)|uniprotkb:Odz4(gene name synonym)|uniprotkb:Protein Odd Oz/ten-m homolog 4(gene name synonym)|uniprotkb:Tenascin-M4(gene name synonym)|uniprotkb:Teneurin transmembrane protein 4(gene name synonym)|uniprotkb:Tnm4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR031325|refseq:NP_001297689.1|refseq:NP_001297691.1|refseq:NP_035988.2|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR008969(Carboxypeptidase-like, regulatory region)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR013111(EGF, extracellular)|interpro:IPR022385|interpro:IPR009471(Teneurin intracellular, N-terminal)|interpro:IPR006530(YD repeat)|interpro:IPR028916|refseq:XP_017177717.1|interpro:IPR027691|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048666"(neuron development)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060912"(cardiac cell fate specification)|go:"GO:2000543"(positive regulation of gastrulation)|mint:Q3UHK6	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:0oVMre4l1F1JwL4Gu0Uz8P2bDew10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O35344	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-3043911|ensembl:ENSMUSP00000022496	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ima4_mouse(display_long)|uniprotkb:Kpna3(gene name)|psi-mi:Kpna3(display_short)|uniprotkb:Qip2(gene name synonym)|uniprotkb:Importin alpha Q2(gene name synonym)|uniprotkb:Karyopherin subunit alpha-3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000021929(gene)|ensembl:ENSMUST00000022496(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O35344|go:"GO:0005634"(nucleus)|refseq:NP_032492.1|dip:DIP-62054N	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:n1z2s11CghKCHD+2w6yOGWbpFYE10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q69ZH9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472113|uniprotkb:Q8BNY7|uniprotkb:Q9JJD6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rhg23_mouse(display_long)|uniprotkb:Arhgap23(gene name)|psi-mi:Arhgap23(display_short)|uniprotkb:Kiaa1501(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 23(gene name synonym)|uniprotkb:MNCb-1301(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0005096"(GTPase activator activity)|go:"GO:0007165"(signal transduction)|reactome:R-MMU-8980692|reactome:R-MMU-9013149|mint:Q69ZH9|refseq:NP_067468.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR041489|interpro:IPR036034|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR041681|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR000198(RhoGAP)	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:KTCeDuLV+qHtInBwC3PzUFi0VO810090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:A2A690	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16733043|ensembl:ENSMUSP00000097904|uniprotkb:A2A683|uniprotkb:Q3TRZ3|uniprotkb:Q5EBP6|uniprotkb:Q69ZQ7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tanc2_mouse(display_long)|uniprotkb:Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2(gene name synonym)|uniprotkb:Tanc2(gene name)|psi-mi:Tanc2(display_short)|uniprotkb:Kiaa1148(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000053580(gene)|ensembl:ENSMUST00000100330(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0030424"(axon)|go:"GO:0043197"(dendritic spine)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099519"(dense core granule cytoskeletal transport)|interpro:IPR002110(Ankyrin)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|mint:A2A690|refseq:NP_851416.2	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:pr3yhn1QUhZm0o9/xXGd9g+QFoo10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O54774	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-775247|ensembl:ENSMUSP00000020420	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ap3d1_mouse(display_long)|uniprotkb:AP-3 complex subunit delta(gene name synonym)|uniprotkb:Delta-adaptin(gene name synonym)|uniprotkb:Ap3d1(gene name)|psi-mi:Ap3d1(display_short)|uniprotkb:Ap3d(gene name synonym)|uniprotkb:Adaptor-related protein complex 3 subunit delta-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_031486.1|dip:DIP-32163N|ensembl:ENSMUSG00000020198(gene)|ensembl:ENSMUST00000020420(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030424"(axon)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043195"(terminal bouton)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048499"(synaptic vesicle membrane organization)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098943"(neurotransmitter receptor transport, postsynaptic endosome to lysosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR010474(Bovine leukaemia virus receptor)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017105(Adaptor protein complex AP-3, delta subunit)|mint:O54774	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:q83u6ORB4zYNuQihE4PI1rhvSkY10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6WVG3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16730134|uniprotkb:Q3T9E3	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kcd12_mouse(display_long)|uniprotkb:Pfetin(gene name synonym)|uniprotkb:Predominantly fetal expressed T1 domain(gene name synonym)|uniprotkb:Kctd12(gene name)|psi-mi:Kctd12(display_short)|uniprotkb:Pfet1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043235"(receptor complex)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051260"(protein homooligomerization)|mint:Q6WVG3|refseq:NP_808383.3|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:5S5rFCAvBhZVG47OqS29CXJxXP810090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8C2E7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-15483746|ensembl:ENSMUSP00000022976|uniprotkb:Q8BGY1|uniprotkb:Q8K2J2	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:wasc5_mouse(display_long)|uniprotkb:Washc5(gene name)|psi-mi:Washc5(display_short)|uniprotkb:Kiaa0196(gene name synonym)|uniprotkb:WASH complex subunit strumpellin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000022350(gene)|ensembl:ENSMUST00000022976(transcript)|go:"GO:0001556"(oocyte maturation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0034629"|go:"GO:0040038"(polar body extrusion after meiotic divisions)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043933"(protein-containing complex organization)|go:"GO:0051125"(regulation of actin nucleation)|go:"GO:0071203"(WASH complex)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0140285"(endosome fission)|interpro:IPR019393|mint:Q8C2E7|go:"GO:0042632"(cholesterol homeostasis)|refseq:NP_705776.2	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:8sJZNUfe6xELTIE/9I62bWYwrWk10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6P5D3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471284|ensembl:ENSMUSP00000083742|uniprotkb:Q3TS93|uniprotkb:Q6NZK4|uniprotkb:Q6P1B4|uniprotkb:Q8BI63|uniprotkb:Q8BIA2|uniprotkb:Q8R360	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dhx57_mouse(display_long)|uniprotkb:Dhx57(gene name)|psi-mi:Dhx57(display_short)|uniprotkb:DEAH box protein 57(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000035051(gene)|ensembl:ENSMUST00000086555(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006575(RWD)|interpro:IPR007502(Helicase-associated region)|interpro:IPR009060(UBA-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR027417|interpro:IPR036855|interpro:IPR042615|mint:Q6P5D3|refseq:NP_001157231.1|refseq:NP_945180.2|refseq:XP_006523510.1|refseq:XP_006523511.1|refseq:XP_017172691.1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:nAZbsulRL3ILa8GPejiItndIZts10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P35922	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-645094	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CJG1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2291996|uniprotkb:A1L365|ensembl:ENSMUSP00000095498|ensembl:ENSMUSP00000159361	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ago1_mouse(display_long)|uniprotkb:Ago1(gene name)|psi-mi:Ago1(display_short)|uniprotkb:Argonaute RISC catalytic component 1(gene name synonym)|uniprotkb:Eif2c1(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 1(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_700452.2|refseq:NP_001304102.1|ensembl:ENSMUSG00000041530(gene)|ensembl:ENSMUST00000097888(transcript)|ensembl:ENSMUST00000239428(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070578"(RISC-loading complex)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG1|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:l/WmIsnfJjifEOoxOyG9zDo2ljQ10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P24270	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2924912|uniprotkb:Q3TXQ6|ensembl:ENSMUSP00000028610	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cata_mouse(display_long)|uniprotkb:Cat(gene name)|psi-mi:Cat(display_short)|uniprotkb:Cas-1(gene name synonym)|uniprotkb:Cas1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0055093"(response to hyperoxia)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0080184"(response to phenylpropanoid)|interpro:IPR002226(Catalase)|interpro:IPR010582(Catalase-related)|interpro:IPR011614(Catalase, N-terminal)|interpro:IPR018028|interpro:IPR020835|interpro:IPR024708|interpro:IPR024711|interpro:IPR040333|mint:P24270|reactome:R-MMU-3299685|reactome:R-MMU-6798695|reactome:R-MMU-9033241|go:"GO:0051781"(positive regulation of cell division)|ensembl:ENSMUSG00000027187(gene)|ensembl:ENSMUST00000028610(transcript)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0004096"(catalase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009642"(response to light intensity)|go:"GO:0009650"(UV protection)|go:"GO:0010193"(response to ozone)|go:"GO:0010288"(response to lead ion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0016209"(antioxidant activity)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019899"(enzyme binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|refseq:NP_033934.2	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Ahsw8/VMIQAUw7mWuBSFRn9g/3M10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CQ21	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26473122|ensembl:ENSMUSP00000100534	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mcts2_mouse(display_long)|uniprotkb:Mcts2(gene name)|psi-mi:Mcts2(display_short)|uniprotkb:Multiple copies T-cell malignancies 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000042814(gene)|ensembl:ENSMUST00000062148(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|interpro:IPR002478(PUA)|interpro:IPR004521(Uncharacterized domain 2)|interpro:IPR015947(PUA-like)|interpro:IPR016437(Translation machinery-associated RNA binding protein, predicted)|interpro:IPR041366|mint:Q9CQ21|refseq:NP_079819.1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:tAXDFylr6cVqjmzxXa70I52GsFU10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P36916	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-17171182|ensembl:ENSMUSP00000084450|uniprotkb:E9QPZ9|uniprotkb:Q91Z20	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:gnl1_mouse(display_long)|uniprotkb:GTP-binding protein MMR1(gene name synonym)|uniprotkb:Gnl1(gene name)|psi-mi:Gnl1(display_short)|uniprotkb:Gna-rs1(gene name synonym)|uniprotkb:Mmr1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000024429(gene)|ensembl:ENSMUST00000087200(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0006974"(cellular response to DNA damage stimulus)|interpro:IPR006073(GTP1/OBG)|interpro:IPR027417|interpro:IPR030378|interpro:IPR043358|mint:P36916|refseq:NP_032162.2	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:5GvOQdadvg4RmdDORomaCEW+7cc10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80X50	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11664310|uniprotkb:Q8BIT6|uniprotkb:Q8BIW4|uniprotkb:Q8BJ01|uniprotkb:Q8CIG7|uniprotkb:Q8K102|uniprotkb:Q9CRT6|ensembl:ENSMUSP00000143459	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ubp2l_mouse(display_long)|uniprotkb:Ubap2l(gene name)|psi-mi:Ubap2l(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001159455.1|refseq:NP_001159456.1|refseq:NP_001159457.1|refseq:NP_001159458.1|refseq:NP_082751.1|refseq:XP_006502235.1|ensembl:ENSMUSG00000042520(gene)|ensembl:ENSMUST00000196843(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031519"(PcG protein complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|mint:Q80X50|rcsb pdb:1WJ7	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ucHEy1MXF7PTEdwLChr6zAOqtcM10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8C3F2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16728136|ensembl:ENSMUSP00000073082|uniprotkb:Q3U0F6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:f120c_mouse(display_long)|uniprotkb:Protein FAM120C(gene name synonym)|uniprotkb:Fam120c(gene name)|psi-mi:Fam120c(display_short)|uniprotkb:ORF34(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000025262(gene)|go:"GO:0005634"(nucleus)|interpro:IPR026784|interpro:IPR026785|interpro:IPR029060|mint:Q8C3F2|ensembl:ENSMUST00000073364(transcript)|refseq:NP_932773.2	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:7t8xHEO+ShbLsdqIbH6xQm7UcPw10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q62443	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470897|ensembl:ENSMUSP00000026670	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nptx1_mouse(display_long)|uniprotkb:Nptx1(gene name)|psi-mi:Nptx1(display_short)|uniprotkb:Neuronal pentraxin I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000025582(gene)|ensembl:ENSMUST00000026670(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0030133"(transport vesicle)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|mint:Q62443|refseq:NP_032756.1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ddE8h5JD7XtrGle7yD9q+E4m/co10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P97445	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-770859|uniprotkb:Q2TPN3|ensembl:ENSMUSP00000112436	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cac1a_mouse(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.1(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide isoform 4(gene name synonym)|uniprotkb:Brain calcium channel I(gene name synonym)|uniprotkb:Cacna1a(gene name)|psi-mi:Cacna1a(display_short)|uniprotkb:Cach4(gene name synonym)|uniprotkb:Cacn3(gene name synonym)|uniprotkb:Cacnl1a4(gene name synonym)|uniprotkb:Ccha1a(gene name synonym)|uniprotkb:Caca1a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_031604.3|ensembl:ENSMUSG00000034656(gene)|ensembl:ENSMUST00000121390(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008219"(cell death)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010817"(regulation of hormone levels)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0014056"(regulation of acetylcholine secretion, neurotransmission)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019905"(syntaxin binding)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021590"(cerebellum maturation)|go:"GO:0021679"(cerebellar molecular layer development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031335"(regulation of sulfur amino acid metabolic process)|go:"GO:0032353"(negative regulation of hormone biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048265"(response to pain)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005448(Voltage-dependent calcium channel, P/Q-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|mint:P97445|reactome:R-MMU-112308|reactome:R-MMU-422356|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050877"(nervous system process)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:0F+rEJNjvjSIeqALxCrthlflD9U10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q61290	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-770918	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cac1e_mouse(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.3(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 6(gene name synonym)|uniprotkb:Brain calcium channel II(gene name synonym)|uniprotkb:Cacna1e(gene name)|psi-mi:Cacna1e(display_short)|uniprotkb:Cach6(gene name synonym)|uniprotkb:Cacnl1a6(gene name synonym)|uniprotkb:Cchra1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR005449(Voltage-dependent calcium channel, R-type, alpha-1 subunit)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR027359|interpro:IPR031649|go:"GO:0001662"(behavioral fear response)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0042596"(fear response)|go:"GO:0043204"(perikaryon)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048265"(response to pain)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0050877"(nervous system process)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0090273"(regulation of somatostatin secretion)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|reactome:R-MMU-112308|reactome:R-MMU-422356|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042593"(glucose homeostasis)|mint:Q61290	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:EaL/xQzdjloSLb88yMW1gqddCjM10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8K2D3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16369796|ensembl:ENSMUSP00000049146|uniprotkb:Q3THV7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:edc3_mouse(display_long)|uniprotkb:YjeF domain-containing protein 1(gene name synonym)|uniprotkb:Edc3(gene name)|psi-mi:Edc3(display_short)|uniprotkb:Yjdc(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:1990174"(phosphodiesterase decapping endonuclease activity)|interpro:IPR004443(YjeF-related protein, N-terminal)|interpro:IPR019050|interpro:IPR025609|interpro:IPR025762|interpro:IPR034107|interpro:IPR036652|mint:Q8K2D3|reactome:R-MMU-430039|ensembl:ENSMUSG00000038957(gene)|ensembl:ENSMUST00000043990(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|refseq:NP_722494.1|refseq:XP_011241062.1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:gxI+R4pKdhtjglIi5z4PNMDktbk10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:E9Q6P5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472026|ensembl:ENSMUSP00000052107	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ttc7b_mouse(display_long)|uniprotkb:Ttc7b(gene name)|psi-mi:Ttc7b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000033530(gene)|ensembl:ENSMUST00000062957(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|mint:E9Q6P5|refseq:NP_001028385.1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ZPk8i1GIUVQ38oFmzSf936xq0lE10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P47962	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-773940|uniprotkb:Q9CR19|ensembl:ENSMUSP00000080854	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl5_mouse(display_long)|uniprotkb:Rpl5(gene name)|psi-mi:Rpl5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_058676.1|ensembl:ENSMUSG00000058558(gene)|ensembl:ENSMUST00000082223(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1905017"(positive regulation of isoleucine-tRNA ligase activity)|go:"GO:1905020"(positive regulation of methionine-tRNA ligase activity)|go:"GO:1905023"(positive regulation of threonine-tRNA ligase activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR005485(Ribosomal protein L5, eukaryotic)|interpro:IPR025607|mint:P47962|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:29DmVSczDJV/5gL/nPYYBBEdo9o10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8K310	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-1216295|ensembl:ENSMUSP00000125761|ensembl:ENSMUSP00000158074|ensembl:ENSMUSP00000158537	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:matr3_mouse(display_long)|uniprotkb:Matr3(gene name)|psi-mi:Matr3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_034901.2|rcsb pdb:1X4F|rcsb pdb:1X4D|ensembl:ENSMUSG00000037236(gene)|ensembl:ENSMUST00000166793(transcript)|ensembl:ENSMUST00000235199(transcript)|ensembl:ENSMUST00000237744(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034928|interpro:IPR034930|interpro:IPR035979|mint:Q8K310	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:AwtFbI+oRfha+mn/v3yzG6bNXYg10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TSH2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-911437|ensembl:ENSMUSP00000050788	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kpbb_mouse(display_long)|uniprotkb:Phkb(gene name)|psi-mi:Phkb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_955517.1|ensembl:ENSMUSG00000036879(gene)|ensembl:ENSMUST00000053771(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|interpro:IPR008734(Phosphorylase kinase alphabeta)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR011613(Glycoside hydrolase 15-related)|mint:Q7TSH2|reactome:R-MMU-70221|refseq:XP_006530595.1|refseq:XP_006530596.1|refseq:XP_006530597.1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:qRovReuecws5KcJl6XVcnVO5FW410090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8BWS5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472832|ensembl:ENSMUSP00000051805|uniprotkb:Q69Z30	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:grin3_mouse(display_long)|uniprotkb:Gprin3(gene name)|psi-mi:Gprin3(display_short)|uniprotkb:Kiaa2027(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000045441(gene)|ensembl:ENSMUST00000051065(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0031175"(neuron projection development)|interpro:IPR026646|interpro:IPR032745|mint:Q8BWS5|refseq:NP_899006.1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:TUt7HEqIihPNC+yWsH42oCCXRVQ10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O88532	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-645485|uniprotkb:Q3TY30|uniprotkb:Q8BS85|uniprotkb:Q8CGG5|uniprotkb:Q91VZ0|uniprotkb:Q9CT34|ensembl:ENSMUSP00000118911	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:zfr_mouse(display_long)|uniprotkb:Zfr(gene name)|psi-mi:Zfr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035897.2|ensembl:ENSMUSG00000022201(gene)|ensembl:ENSMUST00000122941(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR006561(DZF)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043519|mint:O88532	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ncNwFUEUk0r2XotuXm/9Tt4iB5w10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CC12	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470848|ensembl:ENSMUSP00000106329|uniprotkb:A2AW10|uniprotkb:Q149P8|uniprotkb:Q3U032	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cdan1_mouse(display_long)|uniprotkb:Cdan1(gene name)|psi-mi:Cdan1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000027284(gene)|ensembl:ENSMUST00000110701(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0008104"(protein localization)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031497"(chromatin assembly)|interpro:IPR028171|interpro:IPR040031|mint:Q8CC12|refseq:NP_081167.2	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:5Nyg/Fnh9WKYy3DFp/o8OTH4LGA10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P18826	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470825|ensembl:ENSMUSP00000061991|uniprotkb:A2AI90	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kpb1_mouse(display_long)|uniprotkb:Phka1(gene name)|psi-mi:Phka1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000034055(gene)|ensembl:ENSMUST00000052012(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR008734(Phosphorylase kinase alphabeta)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR011613(Glycoside hydrolase 15-related)|interpro:IPR012341(Six-hairpin glycosidase)|mint:P18826|reactome:R-MMU-70221|refseq:NP_032858.2	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:m6KkLpQv72gScTWLDJ2f1g4mtuo10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q08460	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9Z1X4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6260790|ensembl:ENSMUSP00000065770|uniprotkb:Q8BP80|uniprotkb:Q8K588|uniprotkb:Q8C2H8|uniprotkb:Q812A1|uniprotkb:Q80VD5	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ilf3_mouse(display_long)|uniprotkb:Ilf3(gene name)|psi-mi:Ilf3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001264250.1|ensembl:ENSMUSG00000032178(gene)|ensembl:ENSMUST00000067646(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006479"(protein methylation)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR033099|interpro:IPR043519|mint:Q9Z1X4|rcsb pdb:4AT7|rcsb pdb:4AT8|rcsb pdb:4AT9|rcsb pdb:4ATB|rcsb pdb:5DV7|refseq:XP_006510094.1|refseq:NP_001036172.1|refseq:NP_001036173.1|refseq:NP_034691.2|refseq:NP_001264251.1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:vxZan3L6NAseX1Ib9Z7MQ82CM3E10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P07934	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470873|ensembl:ENSMUSP00000026617	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:phkg1_mouse(display_long)|uniprotkb:Phkg1(gene name)|psi-mi:Phkg1(display_short)|uniprotkb:Phkg(gene name synonym)|uniprotkb:Phosphorylase kinase subunit gamma-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PHKG1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000026617(transcript)|go:"GO:0004689"(phosphorylase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR002291(Phosphorylase kinase, gamma catalytic subunit)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P07934|reactome:R-MMU-70221|ensembl:ENSMUSG00000025537(gene)|refseq:NP_035209.1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:oWhiqhcqtIelRPU5Z0TI4T9lskc10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TQH0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6908203|ensembl:ENSMUSP00000035415|uniprotkb:Q80XN9|uniprotkb:Q8K059	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:atx2l_mouse(display_long)|uniprotkb:Atxn2l(gene name)|psi-mi:Atxn2l(display_short)|uniprotkb:A2lp(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_006507788.1|ensembl:ENSMUSG00000032637(gene)|ensembl:ENSMUST00000040202(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010603"(regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0034063"(stress granule assembly)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR025852|mint:Q7TQH0|refseq:NP_898841.1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:7v7iuPRti2err2QrmJIGoWqEM3U10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P56942	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26450331|ensembl:ENSMUSP00000044352|uniprotkb:Q9D220	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mch_mouse(display_long)|uniprotkb:Pmch(gene name)|psi-mi:Pmch(display_short)|uniprotkb:Mch(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000048621(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007631"(feeding behavior)|go:"GO:0009409"(response to cold)|go:"GO:0030354"(melanin-concentrating hormone activity)|go:"GO:0031777"(type 1 melanin-concentrating hormone receptor binding)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042756"(drinking behavior)|go:"GO:0045202"(synapse)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046005"(positive regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|interpro:IPR005456(Pre-pro melanin-concentrating hormone)|mint:P56942|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUSG00000035383(gene)|refseq:NP_084247.1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:l3UbZeUaSJTBhc0jao6eg+D8Q4U10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CXY6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2312782|uniprotkb:Q3U083|uniprotkb:Q5RKG0|uniprotkb:Q8CCY9|uniprotkb:Q99KS3|ensembl:ENSMUSP00000001042	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ilf2_mouse(display_long)|uniprotkb:Ilf2(gene name)|psi-mi:Ilf2(display_short)|uniprotkb:Nf45(gene name synonym)|uniprotkb:Nuclear factor of activated T-cells 45 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080650.1|ensembl:ENSMUSG00000001016(gene)|ensembl:ENSMUST00000001042(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR043519|mint:Q9CXY6|rcsb pdb:4AT7|rcsb pdb:4AT8|rcsb pdb:4AT9|rcsb pdb:4ATB|reactome:R-MMU-6798695	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:HwUDuY6Ev7csoTThxZCW8nJT88o10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6ZPR4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16728165|ensembl:ENSMUSP00000109809|uniprotkb:B2RUK3|uniprotkb:Q8C3E7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kcnt1_mouse(display_long)|uniprotkb:Kcnt1(gene name)|psi-mi:Kcnt1(display_short)|uniprotkb:Kiaa1422(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000058740(gene)|ensembl:ENSMUST00000114172(transcript)|go:"GO:0005228"(intracellular sodium activated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR013099(Ion transport 2)|mint:Q6ZPR4|refseq:NP_001289280.1|refseq:NP_780671.2	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:dqty8xDH9pIQhzgbYTeSOo4tLjA10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P39087	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-396914|uniprotkb:Q60933|ensembl:ENSMUSP00000101124|ensembl:ENSMUSP00000151921	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:grik2_mouse(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym)|uniprotkb:Glutamate receptor beta-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_017169293.1|ensembl:ENSMUSG00000056073(gene)|ensembl:ENSMUST00000105484(transcript)|ensembl:ENSMUST00000218823(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|mint:P39087|reactome:R-MMU-451307|reactome:R-MMU-451308	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:6sgY8SzX07HzilLLeDg3pV+sXkc10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O35099	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-777493|uniprotkb:Q14AY5|ensembl:ENSMUSP00000093485	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:m3k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:Map3k5(gene name)|psi-mi:Map3k5(display_short)|uniprotkb:Ask1(gene name synonym)|uniprotkb:Mekk5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_032606.4|dip:DIP-38055N|ensembl:ENSMUSG00000071369(gene)|ensembl:ENSMUST00000095806(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010941"(regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902170"(cellular response to reactive nitrogen species)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:O35099|reactome:R-MMU-2559580	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:i1P8YtUNmpFauFUVVxzsMYoQYOw10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q64105	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470795|uniprotkb:Q63996	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:spre_mouse(display_long)|uniprotkb:Spr(gene name)|psi-mi:Spr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0004757"(sepiapterin reductase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006558"(L-phenylalanine metabolic process)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0010033"(response to organic substance)|go:"GO:0019889"(pteridine metabolic process)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046146"(tetrahydrobiopterin metabolic process)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050882"(voluntary musculoskeletal movement)|rcsb pdb:1NAS|rcsb pdb:1OAA|rcsb pdb:1SEP|reactome:R-MMU-1474151|reactome:R-MMU-203615|mint:Q64105|interpro:IPR036291|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR006393(Sepiapterin reductase)	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Y4ePCWcq2RI0t59kgHibLyHd6yM10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9Z321	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16728364|ensembl:ENSMUSP00000023465|ensembl:ENSMUSP00000156132	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:top3b_mouse(display_long)|uniprotkb:DNA topoisomerase III beta-1(gene name synonym)|uniprotkb:Top3b(gene name)|psi-mi:Top3b(display_short)|uniprotkb:Top3b1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473140|imex:IM-28526-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000022779(gene)|ensembl:ENSMUST00000023465(transcript)|ensembl:ENSMUST00000232581(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003916"(DNA topoisomerase activity)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007059"(chromosome segregation)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|mint:Q9Z321|refseq:NP_001313505.1|refseq:NP_035754.1|refseq:XP_006522054.1|refseq:XP_006522055.1|refseq:XP_006522057.1|refseq:XP_006522058.1|refseq:XP_017172426.1	-	-	-	figure legend:ST4|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:9m6mpZ7aIV3fx3bU6opc3sFN3SA10090	rigid:TSdM/EyMdaTn7LF7A05k85WL+GQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6NZL8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-7364500|uniprotkb:Q9EQC6|intact:MINT-4653211|uniprotkb:Q8C9Q4|ensembl:ENSMUSP00000016907	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:scub1_mouse(display_long)|uniprotkb:Scube1(gene name)|psi-mi:Scube1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_073560.2|refseq:NP_001258401.1|ensembl:ENSMUSG00000016763(gene)|ensembl:ENSMUST00000016907(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR018097|interpro:IPR024731|interpro:IPR026823|interpro:IPR035914|mint:Q6NZL8|reactome:R-MMU-1474228	-	-	comment:mint|function:Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:7xFgdlcD91RMiaKWtWbcZoHHf4Y10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O09167	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-7977824|intact:MINT-1858045	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl21_mouse(display_long)|uniprotkb:Rpl21(gene name)|psi-mi:Rpl21(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR008991(Translation protein SH3-like)|interpro:IPR018259|interpro:IPR036948|mint:O09167|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|interpro:IPR001147(Ribosomal protein L21e)	-	-	comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:uEJx6Wv/rFvNeu2dalcIkOKkyxo10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P47964	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8365611|intact:MINT-4132614	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl36_mouse(display_long)|uniprotkb:Rpl36(gene name)|psi-mi:Rpl36(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR038097|mint:P47964|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0045202"(synapse)|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|interpro:IPR000509(Ribosomal protein L36e)	-	-	comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:LNDybrXOVq0igi414xuHjWUY1gg10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99KV1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8328260|uniprotkb:Q8VHB1|uniprotkb:Q8VCY1|intact:MINT-1847287|uniprotkb:A6X957|uniprotkb:Q543I7|uniprotkb:Q8BK79|ensembl:ENSMUSP00000004574|ensembl:ENSMUSP00000126828|ensembl:ENSMUSP00000137542	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:djb11_mouse(display_long)|uniprotkb:Dnajb11(gene name)|psi-mi:Dnajb11(display_short)|uniprotkb:ER-associated Hsp40 co-chaperone(gene name synonym)|uniprotkb:ER-associated DNAJ(gene name synonym)|uniprotkb:APOBEC1-binding protein 2(gene name synonym)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080676.3|refseq:NP_001177733.1|refseq:NP_001177734.1|dip:DIP-60531N|ensembl:ENSMUSG00000004460(gene)|ensembl:ENSMUST00000004574(transcript)|ensembl:ENSMUST00000166487(transcript)|ensembl:ENSMUST00000178320(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0016556"(mRNA modification)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|mint:Q99KV1	-	-	comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:AwepE58LUoN43LmBMkof6jEPNCA10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q61315	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-7848277|uniprotkb:Q62044|intact:UNK-5461725	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:apc_mouse(display_long)|uniprotkb:Apc(gene name)|psi-mi:Apc(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0001822"(kidney development)|go:"GO:0001942"(hair follicle development)|go:"GO:0002020"(protease binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009798"(axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042483"(negative regulation of odontogenesis)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043588"(skin development)|go:"GO:0044295"(axonal growth cone)|go:"GO:0031253"(cell projection membrane)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044337"(canonical Wnt signaling pathway involved in positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051171"(regulation of nitrogen compound metabolic process)|go:"GO:0051276"(chromosome organization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070852"(cell body fiber)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000211"(regulation of glutamate metabolic process)|rcsb pdb:1VJ6|reactome:R-MMU-111465|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-3769402|reactome:R-MMU-4641262|reactome:R-MMU-5689896|interpro:IPR032038|mint:Q61315|interpro:IPR009224(SAMP)|interpro:IPR000225(Armadillo)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009232(EB-1 binding)|interpro:IPR026818|interpro:IPR011989(Armadillo-like helical)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR026836|interpro:IPR036149|interpro:IPR041257	-	-	function:Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. APC activity is correlated with its phosphorylation state|comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:5LB5NjRyV0VFe8xzCkg3/o+44g410090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9EQJ9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-7455245|uniprotkb:Q8C0P8|intact:MINT-1894696|uniprotkb:B0V3N7|intact:UNK-5947369|uniprotkb:Q69ZE1|uniprotkb:B0V3N8	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:magi3_mouse(display_long)|uniprotkb:Magi3(gene name)|psi-mi:Magi3(display_short)|uniprotkb:Membrane-associated guanylate kinase inverted 3(gene name synonym)|uniprotkb:Kiaa1634(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR030035|mint:Q9EQJ9|interpro:IPR036034|interpro:IPR036020|interpro:IPR020590|interpro:IPR027417|refseq:NP_598614.1|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|go:"GO:0005109"(frizzled binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0030054"(cell junction)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)	-	-	comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:LbFYUmxao9TmprW22YUA3GS9nCs10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3TJZ6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8318357|intact:MINT-1858128|uniprotkb:Q99KJ2|ensembl:ENSMUSP00000108126	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:fa98a_mouse(display_long)|uniprotkb:Fam98a(gene name)|psi-mi:Fam98a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_598508.2|ensembl:ENSMUSG00000002017(gene)|ensembl:ENSMUST00000112507(transcript)|go:"GO:0006479"(protein methylation)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032418"(lysosome localization)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR018797|mint:Q3TJZ6	-	-	comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ZvcKhnXQtXNW4jEx2X8IvALCfZU10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8VDJ3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8317711|intact:MINT-1858511|ensembl:ENSMUSP00000043047|ensembl:ENSMUSP00000127903	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:vigln_mouse(display_long)|uniprotkb:Hdlbp(gene name)|psi-mi:Hdlbp(display_short)|uniprotkb:High density lipoprotein-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001288293.1|refseq:NP_598569.1|refseq:XP_006529137.1|refseq:XP_006529138.1|refseq:XP_006529139.1|refseq:XP_006529140.1|ensembl:ENSMUSG00000034088(gene)|ensembl:ENSMUST00000042498(transcript)|ensembl:ENSMUST00000170883(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006869"(lipid transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0034364"(high-density lipoprotein particle)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q8VDJ3|reactome:R-MMU-8964011	-	-	function:Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol|comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:H8VW/Tp0f9b24nwslsUWF+CW/xE10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P59325	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8312397|ensembl:ENSMUSP00000061616|ensembl:ENSMUSP00000126825|ensembl:ENSMUSP00000152791|intact:MINT-1857485	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:if5_mouse(display_long)|uniprotkb:Eif5(gene name)|psi-mi:Eif5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000021282(gene)|ensembl:ENSMUST00000050993(transcript)|ensembl:ENSMUST00000166123(transcript)|ensembl:ENSMUST00000222375(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|mint:P59325|reactome:R-MMU-72702|reactome:R-MMU-72706|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|refseq:NP_829887.1|refseq:NP_775539.1	-	-	comment:mint|function:"Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F])"	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:OQ4olrPlHrkjB/J46gKEVh4EEyY10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3UKJ7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8329447|uniprotkb:Q8BMY4|uniprotkb:Q6PFR6|uniprotkb:Q9JJ70|uniprotkb:Q9D1I8|intact:MINT-4129849|ensembl:ENSMUSP00000030117	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:smu1_mouse(display_long)|uniprotkb:Smu1(gene name)|psi-mi:Smu1(display_short)|uniprotkb:Smu-1 suppressor of mec-8 and unc-52 protein homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_067510.3|ensembl:ENSMUSG00000028409(gene)|ensembl:ENSMUST00000030117(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q3UKJ7	-	-	comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:zbTRfKynNIUSFY8IEqyYWh3JSho10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9DB34	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8586095|ensembl:ENSMUSP00000005711|ensembl:ENSMUSP00000148218|intact:MINT-4616048	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:chm2a_mouse(display_long)|uniprotkb:Chmp2a(gene name)|psi-mi:Chmp2a(display_short)|uniprotkb:Chromatin-modifying protein 2a(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000033916(gene)|ensembl:ENSMUST00000005711(transcript)|ensembl:ENSMUST00000210587(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010324"(membrane invagination)|go:"GO:0010458"(exit from mitosis)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0051258"(protein polymerization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061952"(midbody abscission)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903723"(negative regulation of centriole elongation)|interpro:IPR005024(Snf7)|mint:Q9DB34|reactome:R-MMU-1632852|reactome:R-MMU-432720|reactome:R-MMU-5620971|reactome:R-MMU-917729|reactome:R-MMU-9668328|refseq:NP_081161.1|refseq:XP_006540408.1	-	-	function:"Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-III complex is probably involved in the concentration of MVB cargo"|comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:051SRxX9fp9iO4KjddWtca50mnA10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9R0P4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8586111|ensembl:ENSMUSP00000032899|intact:UNK-5555069	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:smap_mouse(display_long)|uniprotkb:Smap(gene name)|psi-mi:Smap(display_short)|uniprotkb:Sid2057(gene name synonym)|uniprotkb:Sid 2057(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000030663(gene)|ensembl:ENSMUST00000032899(transcript)|interpro:IPR028124|mint:Q9R0P4|interpro:IPR026714|refseq:NP_062746.1	-	-	comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:D+c9eTtcxW+o7VPh58smJyc9aZU10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9DB27	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8317814|intact:MINT-4128072|uniprotkb:Q3UUI6|intact:UNK-5416843|ensembl:ENSMUSP00000000365	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mcts1_mouse(display_long)|uniprotkb:Mcts1(gene name)|psi-mi:Mcts1(display_short)|uniprotkb:Multiple copies T-cell malignancies 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_081178.1|refseq:XP_006541598.1|ensembl:ENSMUSG00000000355(gene)|ensembl:ENSMUST00000000365(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0040008"(regulation of growth)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR002478(PUA)|interpro:IPR004521(Uncharacterized domain 2)|interpro:IPR015947(PUA-like)|interpro:IPR016437(Translation machinery-associated RNA binding protein, predicted)|interpro:IPR041366|mint:Q9DB27	-	-	comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:kbGy09T3EiKnImwwO2ibi9XTUwg10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CHG7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-7027510|ensembl:ENSMUSP00000114119|intact:MINT-4133098|uniprotkb:E9QMD0	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rpgf2_mouse(display_long)|uniprotkb:Rapgef2(gene name)|psi-mi:Rapgef2(display_short)|uniprotkb:Kiaa0313(gene name synonym)|uniprotkb:Pdzgef1(gene name synonym)|uniprotkb:Neural RAP guanine nucleotide exchange protein(gene name synonym)|uniprotkb:PDZ domain-containing guanine nucleotide exchange factor 1(gene name synonym)|uniprotkb:Cyclic nucleotide ras GEF(gene name synonym)|uniprotkb:RA-GEF-1(gene name synonym)|uniprotkb:Ras/Rap1-associating GEF-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_006502317.1|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|go:"GO:0050699"(WW domain binding)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000159(Ras-association)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR018490|interpro:IPR023578|interpro:IPR029071|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030739|interpro:IPR036034|mint:Q8CHG7|reactome:R-MMU-5673001|ensembl:ENSMUSG00000062232(gene)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0021591"(ventricular system development)|go:"GO:0021884"(forebrain neuron development)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031547"(brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038180"(nerve growth factor signaling pathway)|ensembl:ENSMUST00000118100(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001764"(neuron migration)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0045202"(synapse)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048022"(negative regulation of melanin biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	comment:"fragmentation type: fragment"|comment:mint|comment:homomint|function:"Guanine nucleotide exchange factor (GEF) for Rap1, Rap1B and Rap2 GTPases"	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:gH1WVMkcR44bJMCVvh7NctDb5KI10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8BK67	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8357590|uniprotkb:A2AWQ3|uniprotkb:Q6ZPQ0|intact:MINT-4111085|ensembl:ENSMUSP00000038144|ensembl:ENSMUSP00000071163	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rcc2_mouse(display_long)|uniprotkb:Rcc2(gene name)|psi-mi:Rcc2(display_short)|uniprotkb:Kiaa1470(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_776292.1|refseq:XP_006538534.1|ensembl:ENSMUSG00000040945(gene)|ensembl:ENSMUST00000038893(transcript)|ensembl:ENSMUST00000071169(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034506"(chromosome, centromeric core domain)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051301"(cell division)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0072356"(chromosome passenger complex localization to kinetochore)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|mint:Q8BK67|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|interpro:IPR028641	-	-	comment:mint|function:Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:drUhR8O/tjyyyti5OLk0hM0VIW010090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q91W18	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8329718|uniprotkb:Q8C1A4|uniprotkb:Q8BZW6|intact:UNK-5479555|intact:MINT-4137349|uniprotkb:E9Q2Q4|intact:UNK-5512156|uniprotkb:Q6NZG7|ensembl:ENSMUSP00000129019	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tdrd3_mouse(display_long)|uniprotkb:Tdrd3(gene name)|psi-mi:Tdrd3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001240684.1|refseq:NP_766193.3|ensembl:ENSMUSG00000022019(gene)|ensembl:ENSMUST00000168275(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006397"(mRNA processing)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035145"(exon-exon junction complex)|interpro:IPR002999(Tudor)|interpro:IPR009060(UBA-like)|interpro:IPR010304(Survival motor neuron)|interpro:IPR013894(Region of unknown function DUF1767)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR033472|interpro:IPR041915|interpro:IPR042470|mint:Q91W18|rcsb pdb:2D9T	-	-	comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:OJkc6E7+tTHuVr5BSCn8MtiApZk10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8K1N4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8440204|uniprotkb:Q8C810|uniprotkb:Q3UX77|uniprotkb:Q8R1P6|intact:MINT-4117082|ensembl:ENSMUSP00000070549	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:spas2_mouse(display_long)|uniprotkb:Spats2(gene name)|psi-mi:Spats2(display_short)|uniprotkb:Scr59(gene name synonym)|uniprotkb:Serine-rich spermatocytes and round spermatid 59 kDa protein(gene name synonym)|uniprotkb:p59scr(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_011244039.1|refseq:NP_631879.1|ensembl:ENSMUSG00000051934(gene)|ensembl:ENSMUST00000063517(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR009060(UBA-like)|interpro:IPR009816(Protein of unknown function DUF1387)|mint:Q8K1N4	-	-	comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:pHYbbujEidsiqFiPzHScEMINoTI10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P54103	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8419268|uniprotkb:Q61866|intact:MINT-4373956|ensembl:ENSMUSP00000030771	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dnjc2_mouse(display_long)|uniprotkb:Mida1(gene name synonym)|uniprotkb:Zuotin-related factor 1(gene name synonym)|uniprotkb:Mouse Id associate 1(gene name synonym)|uniprotkb:Dnajc2(gene name)|psi-mi:Dnajc2(display_short)|uniprotkb:Zrf1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_033610.1|ensembl:ENSMUSG00000029014(gene)|ensembl:ENSMUST00000030771(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006325"(chromatin organization)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042393"(histone binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051083"('de novo' cotranslational protein folding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR018253|interpro:IPR032003|interpro:IPR036869|interpro:IPR042569|interpro:IPR044634|mint:P54103|reactome:R-MMU-3371453	-	-	comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:X6yxHlv7HhRm7uT74U8rX3aDpl010090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CGF7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-7964269|intact:MINT-7969933|uniprotkb:Q61051|uniprotkb:Q8C490|uniprotkb:Q8CHT8|uniprotkb:Q9R0R5|ensembl:ENSMUSP00000158288	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tcrg1_mouse(display_long)|uniprotkb:Tcerg1(gene name)|psi-mi:Tcerg1(display_short)|uniprotkb:Formin-binding protein 28(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 2S(gene name synonym)|uniprotkb:Taf2s(gene name synonym)|uniprotkb:Transcription factor CA150(gene name synonym)|uniprotkb:p144(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001034563.1|refseq:XP_006526178.1|refseq:NP_001276455.1|ensembl:ENSMUSG00000024498(gene)|ensembl:ENSMUST00000237602(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0042802"(identical protein binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR002713(FF)|interpro:IPR036020|interpro:IPR036517|mint:Q8CGF7|rcsb pdb:1E0L|rcsb pdb:2JUP|rcsb pdb:2RLY|rcsb pdb:2RM0|rcsb pdb:2YSI|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)	-	-	comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:l0JizdwOK12oL38q8XfhOUyv6oM10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99J85	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8311244|intact:MINT-4104086	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nptxr_mouse(display_long)|uniprotkb:Nptxr(gene name)|psi-mi:Nptxr(display_short)|uniprotkb:Npr(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0008029"(pentraxin receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099150"(regulation of postsynaptic specialization assembly)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR030476|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|mint:Q99J85	-	-	comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:AWabDfkkTcL+AMgJlRt5ntbJ5WU10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q91WM1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8339684|intact:MINT-4121401|uniprotkb:Q62262|ensembl:ENSMUSP00000028279|ensembl:ENSMUSP00000072047	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:strbp_mouse(display_long)|uniprotkb:Strbp(gene name)|psi-mi:Strbp(display_short)|uniprotkb:Spnr(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_011237348.1|refseq:XP_011237349.1|refseq:NP_033287.2|refseq:XP_017172309.1|refseq:XP_017172310.1|refseq:XP_017172311.1|refseq:XP_017172312.1|ensembl:ENSMUSG00000026915(gene)|ensembl:ENSMUST00000028279(transcript)|ensembl:ENSMUST00000072186(transcript)|go:"GO:0002177"(manchette)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0007638"(mechanosensory behavior)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR030446|interpro:IPR043519|interpro:IPR044472|mint:Q91WM1	-	-	comment:mint|function:"Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth (By similarity). Binds to double-stranded DNA and RNA (By similarity). Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA (By similarity). Binds also to single-stranded poly(G) RNA (By similarity). Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA"	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:+sf/OyoCMvzDmHmCmq4Me4jWjco10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9D3E6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8430060|uniprotkb:O08982|intact:MINT-4135756|uniprotkb:Q6P5D1|ensembl:ENSMUSP00000116205	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:stag1_mouse(display_long)|uniprotkb:Stag1(gene name)|psi-mi:Stag1(display_short)|uniprotkb:Sa1(gene name synonym)|uniprotkb:Stromal antigen 1(gene name synonym)|uniprotkb:SCC3 homolog 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_033308.2|refseq:XP_006510986.1|refseq:XP_006510987.1|ensembl:ENSMUSG00000037286(gene)|ensembl:ENSMUST00000129269(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0051301"(cell division)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR013721(STAG)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR020839|interpro:IPR039662|mint:Q9D3E6|reactome:R-MMU-2467813|reactome:R-MMU-2468052|reactome:R-MMU-2470946|reactome:R-MMU-2500257|reactome:R-MMU-3108214	-	-	function:Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis|comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:s1WGi5ZDTZuZS4q0KFS/tvL+FXk10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99PU8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8329235|uniprotkb:Q3UFA0|uniprotkb:Q3U4Z4|uniprotkb:Q91WA7|uniprotkb:Q3UJS4|intact:MINT-1861298|uniprotkb:Q99KN7|ensembl:ENSMUSP00000129174|ensembl:ENSMUSP00000142659	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dhx30_mouse(display_long)|uniprotkb:Dhx30(gene name)|psi-mi:Dhx30(display_short)|uniprotkb:Helg(gene name synonym)|uniprotkb:DEAH box protein 30(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_011241331.1|refseq:NP_001239611.1|refseq:NP_001239612.1|refseq:NP_579925.1|refseq:XP_006512361.1|refseq:XP_006512362.1|refseq:XP_006512363.1|refseq:XP_006512364.1|refseq:XP_006512366.1|refseq:XP_006512367.1|refseq:XP_006512368.1|refseq:XP_017169102.1|refseq:XP_017169103.1|ensembl:ENSMUSG00000032480(gene)|ensembl:ENSMUST00000165596(transcript)|ensembl:ENSMUST00000198425(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007417"(central nervous system development)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902775"(mitochondrial large ribosomal subunit assembly)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|mint:Q99PU8	-	-	comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:h1ALiRJkq18+pcpqjWIEOiEXkwE10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9QWR8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8408113|uniprotkb:Q8VDK2|uniprotkb:Q8R437|intact:MINT-1849631|uniprotkb:O88620|ensembl:ENSMUSP00000023088	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nagab_mouse(display_long)|uniprotkb:Naga(gene name)|psi-mi:Naga(display_short)|uniprotkb:Alpha-galactosidase B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_032695.3|ensembl:ENSMUSG00000022453(gene)|ensembl:ENSMUST00000023088(transcript)|go:"GO:0004557"(alpha-galactosidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0008456"(alpha-N-acetylgalactosaminidase activity)|go:"GO:0009311"(oligosaccharide metabolic process)|go:"GO:0016052"(carbohydrate catabolic process)|go:"GO:0016139"(glycoside catabolic process)|go:"GO:0019377"(glycolipid catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046477"(glycosylceramide catabolic process)|interpro:IPR000111(Glycoside hydrolase, clan GH-D)|interpro:IPR002241(Glycoside hydrolase, family 27)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR035373|mint:Q9QWR8	-	-	comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:FePYsDH6Mo8duXIXoo0mX+0smak10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9JLZ3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8345249|uniprotkb:Q8QZS0|intact:MINT-1861987|uniprotkb:Q80YD7|uniprotkb:Q9CY78|uniprotkb:Q9D155	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:auhm_mouse(display_long)|uniprotkb:Itaconyl-CoA hydratase(gene name synonym)|uniprotkb:Auh(gene name)|psi-mi:Auh(display_short)|uniprotkb:AU-specific RNA-binding enoyl-CoA hydratase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_057918.2|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR018376|interpro:IPR029045|mint:Q9JLZ3|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0004490"(methylglutaconyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009083"(branched-chain amino acid catabolic process)|go:"GO:0050011"(itaconyl-CoA hydratase activity)|reactome:R-MMU-70895|interpro:IPR001753(Crotonase, core)	-	-	comment:mint|function:Catalyzes the conversion of 3-methylglutaconyl-CoA to 3-hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5'-AUUUA-3' motifs	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:jb9Xjp4DtGg5cI4jv2hmjaydamk10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99LD9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8314252|ensembl:ENSMUSP00000004910|intact:MINT-4094186	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ei2bb_mouse(display_long)|uniprotkb:Eif2b2(gene name)|psi-mi:Eif2b2(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000004788(gene)|ensembl:ENSMUST00000004910(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|go:"GO:0007417"(central nervous system development)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030424"(axon)|go:"GO:0042552"(myelination)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042529|mint:Q99LD9|reactome:R-MMU-72731|refseq:NP_663420.1	-	-	function:Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP|comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:7KakeCPp97n6TE2HaAeWZsfnpHM10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6A0A9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8327719|intact:MINT-1858841|uniprotkb:Q91Z16|uniprotkb:B3DFJ0|uniprotkb:A0PJK6|ensembl:ENSMUSP00000053877	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:f120a_mouse(display_long)|uniprotkb:Kiaa0183(gene name synonym)|uniprotkb:Ossa(gene name synonym)|uniprotkb:Oxidative stress-associated Src activator(gene name synonym)|uniprotkb:Protein FAM120A(gene name synonym)|uniprotkb:FAM120A(gene name)|psi-mi:FAM120A(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001028440.2|ensembl:ENSMUSG00000038014(gene)|ensembl:ENSMUST00000060805(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR026784|interpro:IPR029060|mint:Q6A0A9	-	-	comment:"fragmentation type: fragment"|comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:tZj0TOhfuvvF4GaEPHI7jWpKyl810090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6PGC1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8428992|uniprotkb:Q8C9H9|uniprotkb:Q8C9B7|intact:MINT-4112300|uniprotkb:Q8BQJ4|uniprotkb:Q8BT01|ensembl:ENSMUSP00000035244	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dhx29_mouse(display_long)|uniprotkb:Dhx29(gene name)|psi-mi:Dhx29(display_short)|uniprotkb:DEAH box protein 29(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_766182.2|ensembl:ENSMUSG00000042426(gene)|ensembl:ENSMUST00000038574(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0008494"(translation activator activity)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042255"(ribosome assembly)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR034730|mint:Q6PGC1	-	-	comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:rORkrwC6jPYK8bp9O+7RaI5e9KI10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P52479	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8327299|uniprotkb:Q6ZQG9|uniprotkb:Q91VY7|uniprotkb:Q3TZB8|intact:MINT-1870263|uniprotkb:Q3U5E0|uniprotkb:Q3T9L4|uniprotkb:Q3TNN5|ensembl:ENSMUSP00000104616	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ubp10_mouse(display_long)|uniprotkb:Usp10(gene name)|psi-mi:Usp10(display_short)|uniprotkb:Ode-1(gene name synonym)|uniprotkb:Uchrp(gene name synonym)|uniprotkb:Kiaa0190(gene name synonym)|uniprotkb:Ubiquitin thioesterase 10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 10(gene name synonym)|uniprotkb:Deubiquitinating enzyme 10(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001297559.1|refseq:NP_033488.1|ensembl:ENSMUSG00000031826(gene)|ensembl:ENSMUST00000108988(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR018200|interpro:IPR028767|interpro:IPR028889|interpro:IPR038765|mint:P52479|reactome:R-MMU-5656169|reactome:R-MMU-5689880	-	-	comment:mint|function:Ubiquitin specific protease are required to remove ubiquitin from specific proteins or peptides to which ubiquitin is attached	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:tdoxBRcosuC3GGqMGB5pBKA9pKc10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q61584	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	-	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:B2RR83	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-8572369|ensembl:ENSMUSP00000048340|intact:MINT-8174232	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ytdc2_mouse(display_long)|uniprotkb:Keen to exit meiosis leaving testes under-populated protein(gene name synonym)|uniprotkb:YTH domain-containing protein C2(gene name synonym)|uniprotkb:Ythdc2(gene name)|psi-mi:Ythdc2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR007275(YT521-B-like protein)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031083|interpro:IPR034083|interpro:IPR036770|interpro:IPR036867|mint:B2RR83|ensembl:ENSMUSG00000034653(gene)|ensembl:ENSMUST00000037763(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007286"(spermatid development)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048599"(oocyte development)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR001374(Single-stranded nucleic acid binding R3H)|refseq:NP_001156485.1	-	-	comment:mint	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:TxNENB71AFsznI6fFqBPUX8pgdA10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q0KL02	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16725543|uniprotkb:Q3U522|uniprotkb:Q6P9K6|uniprotkb:Q80W23	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:trio_mouse(display_long)|uniprotkb:Trio(gene name)|psi-mi:Trio(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0019899"(enzyme binding)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-MMU-193648|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-418885|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013423|mint:Q0KL02|refseq:NP_001074771.1|refseq:XP_006520117.1|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR036865|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|interpro:IPR028570	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:nUVpjuymw6gIq+G/H2xcZJh55a810090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CJG1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2291996|uniprotkb:A1L365|ensembl:ENSMUSP00000095498|ensembl:ENSMUSP00000159361	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ago1_mouse(display_long)|uniprotkb:Ago1(gene name)|psi-mi:Ago1(display_short)|uniprotkb:Argonaute RISC catalytic component 1(gene name synonym)|uniprotkb:Eif2c1(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 1(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_700452.2|refseq:NP_001304102.1|ensembl:ENSMUSG00000041530(gene)|ensembl:ENSMUST00000097888(transcript)|ensembl:ENSMUST00000239428(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070578"(RISC-loading complex)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG1|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:l/WmIsnfJjifEOoxOyG9zDo2ljQ10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P11881	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-541478|uniprotkb:P20943|uniprotkb:Q99LG5|ensembl:ENSMUSP00000032192	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:itpr1_mouse(display_long)|uniprotkb:Type 1 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 1(gene name synonym)|uniprotkb:Inositol 1,4,5-trisphosphate-binding protein P400(gene name synonym)|uniprotkb:Purkinje cell protein 1(gene name synonym)|uniprotkb:Protein PCD-6(gene name synonym)|uniprotkb:Itpr1(gene name)|psi-mi:Itpr1(display_short)|uniprotkb:Insp3r(gene name synonym)|uniprotkb:Pcd6(gene name synonym)|uniprotkb:Pcp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_034715.3|refseq:XP_006505693.1|refseq:XP_006505699.1|refseq:XP_006505700.1|dip:DIP-32243N|refseq:XP_017176897.1|refseq:XP_017176899.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0098794"(postsynapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|mint:P11881|rcsb pdb:1N4K|rcsb pdb:1XZZ|rcsb pdb:5GUG|rcsb pdb:5X9Z|rcsb pdb:5XA0|rcsb pdb:5XA1|reactome:R-MMU-114508|reactome:R-MMU-139853|reactome:R-MMU-381676|reactome:R-MMU-418457|reactome:R-MMU-5578775|reactome:R-MMU-983695|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097421"(liver regeneration)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098695"(inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels)|go:"GO:0098793"(presynapse)|ensembl:ENSMUSG00000030102(gene)|ensembl:ENSMUST00000032192(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:O+LA4/Acwos+RNtyqL3IgAe/kkk10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9D6G9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470970|ensembl:ENSMUSP00000036138|uniprotkb:Q9DB66	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cklf5_mouse(display_long)|uniprotkb:Cmtm5(gene name)|psi-mi:Cmtm5(display_short)|uniprotkb:Cklfsf5(gene name synonym)|uniprotkb:Chemokine-like factor superfamily member 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000040759(gene)|ensembl:ENSMUST00000037814(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045662"(negative regulation of myoblast differentiation)|interpro:IPR008253(Marvel)|mint:Q9D6G9|refseq:NP_080342.1|refseq:XP_017171651.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Kj8DRGtMwsoKRnanvRkfzDr+4J810090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99J31	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-12517589|ensembl:ENSMUSP00000033560|ensembl:ENSMUSP00000109457|uniprotkb:Q544K7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ophn1_mouse(display_long)|uniprotkb:Ophn1(gene name)|psi-mi:Ophn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000031214(gene)|ensembl:ENSMUST00000033560(transcript)|ensembl:ENSMUST00000113826(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0034329"(cell junction assembly)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|interpro:IPR000198(RhoGAP)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|mint:Q99J31|reactome:R-MMU-9013406|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013423|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|refseq:NP_001300683.1|refseq:NP_001300684.1|refseq:NP_001300685.1|refseq:NP_443208.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:xgvDj9c8xw1/D2QQyFY4/ywYlZw10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P59644	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472972|ensembl:ENSMUSP00000046625|uniprotkb:Q3TDM9	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:pi5pa_mouse(display_long)|uniprotkb:Inpp5j(gene name)|psi-mi:Inpp5j(display_short)|uniprotkb:Pib5pa(gene name synonym)|uniprotkb:Inositol polyphosphate 5-phosphatase J(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000034570(gene)|ensembl:ENSMUST00000044507(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR041611|mint:P59644|reactome:R-MMU-1660499|reactome:R-MMU-1855183|reactome:R-MMU-1855204|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|refseq:NP_766027.2	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:CkCMJcgIIslEYGnSK82TfllYIgs10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6P5D3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471284|ensembl:ENSMUSP00000083742|uniprotkb:Q3TS93|uniprotkb:Q6NZK4|uniprotkb:Q6P1B4|uniprotkb:Q8BI63|uniprotkb:Q8BIA2|uniprotkb:Q8R360	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dhx57_mouse(display_long)|uniprotkb:Dhx57(gene name)|psi-mi:Dhx57(display_short)|uniprotkb:DEAH box protein 57(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000035051(gene)|ensembl:ENSMUST00000086555(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006575(RWD)|interpro:IPR007502(Helicase-associated region)|interpro:IPR009060(UBA-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR027417|interpro:IPR036855|interpro:IPR042615|mint:Q6P5D3|refseq:NP_001157231.1|refseq:NP_945180.2|refseq:XP_006523510.1|refseq:XP_006523511.1|refseq:XP_017172691.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:nAZbsulRL3ILa8GPejiItndIZts10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3U4G0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470987|ensembl:ENSMUSP00000106543|uniprotkb:Q80WT3|uniprotkb:Q8C1X6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cdin1_mouse(display_long)|uniprotkb:Cdin1(gene name)|psi-mi:Cdin1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000040282(gene)|ensembl:ENSMUST00000110918(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030218"(erythrocyte differentiation)|interpro:IPR029404|mint:Q3U4G0|refseq:NP_001139370.1|refseq:NP_997147.3	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:gJ5bh/GvxiLfIKZVcJBRB/LWpzY10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q69ZU6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-9673461|uniprotkb:Q3TP01|uniprotkb:Q3UWV1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ths7a_mouse(display_long)|uniprotkb:Thsd7a(gene name)|psi-mi:Thsd7a(display_short)|uniprotkb:Gm837(gene name synonym)|uniprotkb:Kiaa0960(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	mint:Q69ZU6|interpro:IPR000884(Thrombospondin, type I)|refseq:NP_001158277.1|interpro:IPR036383|interpro:IPR044004|go:"GO:0001525"(angiogenesis)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0098846"(podocyte foot)|reactome:R-MMU-5173214	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:/qTgHz4eRmV8fo7eOtIiStWEzrw10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P97445	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-770859|uniprotkb:Q2TPN3|ensembl:ENSMUSP00000112436	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cac1a_mouse(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.1(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide isoform 4(gene name synonym)|uniprotkb:Brain calcium channel I(gene name synonym)|uniprotkb:Cacna1a(gene name)|psi-mi:Cacna1a(display_short)|uniprotkb:Cach4(gene name synonym)|uniprotkb:Cacn3(gene name synonym)|uniprotkb:Cacnl1a4(gene name synonym)|uniprotkb:Ccha1a(gene name synonym)|uniprotkb:Caca1a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_031604.3|ensembl:ENSMUSG00000034656(gene)|ensembl:ENSMUST00000121390(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008219"(cell death)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010817"(regulation of hormone levels)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0014056"(regulation of acetylcholine secretion, neurotransmission)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019905"(syntaxin binding)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021590"(cerebellum maturation)|go:"GO:0021679"(cerebellar molecular layer development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031335"(regulation of sulfur amino acid metabolic process)|go:"GO:0032353"(negative regulation of hormone biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048265"(response to pain)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005448(Voltage-dependent calcium channel, P/Q-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|mint:P97445|reactome:R-MMU-112308|reactome:R-MMU-422356|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050877"(nervous system process)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:0F+rEJNjvjSIeqALxCrthlflD9U10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:A2RSY6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471734|uniprotkb:Q0VGB9|uniprotkb:Q3UFG1|uniprotkb:Q3UKB0|uniprotkb:Q8C2S4|uniprotkb:Q8CI50|uniprotkb:Q8R203|uniprotkb:Q9CT68	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:trm1l_mouse(display_long)|uniprotkb:Trmt1l(gene name)|psi-mi:Trmt1l(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0000049"(tRNA binding)|go:"GO:0002940"(tRNA N2-guanine methylation)|go:"GO:0004809"("tRNA (guanine-N2-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0030534"(adult behavior)|go:"GO:0046872"(metal ion binding)|mint:A2RSY6|refseq:NP_081152.2|interpro:IPR029063|interpro:IPR002905(N2,N2-dimethylguanosine tRNA methyltransferase)|interpro:IPR042296|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:kZky6wGrlfi/HQFN9ZEkxXltNt010090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6WVG3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16730134|uniprotkb:Q3T9E3	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kcd12_mouse(display_long)|uniprotkb:Pfetin(gene name synonym)|uniprotkb:Predominantly fetal expressed T1 domain(gene name synonym)|uniprotkb:Kctd12(gene name)|psi-mi:Kctd12(display_short)|uniprotkb:Pfet1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043235"(receptor complex)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051260"(protein homooligomerization)|mint:Q6WVG3|refseq:NP_808383.3|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:5S5rFCAvBhZVG47OqS29CXJxXP810090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TPV4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-1373622|uniprotkb:O35851|uniprotkb:Q80Y66|uniprotkb:Q8R4X2|uniprotkb:Q99KP0|ensembl:ENSMUSP00000044827	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mbb1a_mouse(display_long)|uniprotkb:Mybbp1a(gene name)|psi-mi:Mybbp1a(display_short)|uniprotkb:P160(gene name synonym)|uniprotkb:Myb-binding protein of 160 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_058056.2|dip:DIP-39831N|ensembl:ENSMUSG00000040463(gene)|ensembl:ENSMUST00000045633(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070888"(E-box binding)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR007015(DNA polymerase V)|interpro:IPR016024(Armadillo-type fold)|mint:Q7TPV4|reactome:R-MMU-5250924	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:rt1TQLZB7JNBkpt3DooDAlzOYCo10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:B2RRE7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16728605|ensembl:ENSMUSP00000133939|uniprotkb:B7ZNI5|uniprotkb:Q80TL3|uniprotkb:Q9CUN2	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:otud4_mouse(display_long)|uniprotkb:Otud4(gene name)|psi-mi:Otud4(display_short)|uniprotkb:Kiaa1046(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000036990(gene)|ensembl:ENSMUST00000173078(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|mint:B2RRE7|refseq:NP_001074633.1|refseq:NP_001242962.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:hvTooCUd0wIF+PvtoaDsmYWo4/s10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TMK9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2735641|uniprotkb:O88991|uniprotkb:Q2YDV8|uniprotkb:Q68ED6|uniprotkb:Q80YV6|uniprotkb:Q8BGP1|uniprotkb:Q8C5K6|uniprotkb:Q8CGC2|uniprotkb:Q91ZR0|uniprotkb:Q99KU9|uniprotkb:Q9QYF4|ensembl:ENSMUSP00000133649	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:hnrpq_mouse(display_long)|uniprotkb:Syncrip(gene name)|psi-mi:Syncrip(display_short)|uniprotkb:Hnrpq(gene name synonym)|uniprotkb:Nsap1(gene name synonym)|uniprotkb:Nsap1l(gene name synonym)|uniprotkb:Synaptotagmin-binding, cytoplasmic RNA-interacting protein(gene name synonym)|uniprotkb:Glycine- and tyrosine-rich RNA-binding protein(gene name synonym)|uniprotkb:NS1-associated protein 1(gene name synonym)|uniprotkb:pp68(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001271257.1|refseq:NP_062640.2|refseq:NP_062770.1|refseq:NP_001298042.1|ensembl:ENSMUSG00000032423(gene)|ensembl:ENSMUST00000173801(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006397"(mRNA processing)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006535(HnRNP R and Q splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034544|interpro:IPR034548|interpro:IPR035979|interpro:IPR041337|mint:Q7TMK9	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Ljuz8koebOL7L9jFBaevQYHinzw10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CQE6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2657826|ensembl:ENSMUSP00000020004	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:asf1a_mouse(display_long)|uniprotkb:Asf1a(gene name)|psi-mi:Asf1a(display_short)|uniprotkb:Anti-silencing function protein 1 homolog A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_079817.1|ensembl:ENSMUSG00000019857(gene)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|interpro:IPR006818(Anti-silencing protein, ASF1-like)|interpro:IPR036747|mint:Q9CQE6|reactome:R-MMU-2559584|ensembl:ENSMUST00000020004(transcript)	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:vk5q7y+R+YXFDi/CPKosaFPSf3w10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q71LX4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2255655|uniprotkb:E9QM49|uniprotkb:Q8BWK0	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tln2_mouse(display_long)|uniprotkb:Tln2(gene name)|psi-mi:Tln2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	mint:Q71LX4|refseq:NP_001074711.2|dip:DIP-53098N|go:"GO:0001726"(ruffle)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0045202"(synapse)|go:"GO:0051015"(actin filament binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036723|interpro:IPR037438|rcsb pdb:3G9W|interpro:IPR036476	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:fPA7JK3ca5p+y6dQlF+Srehsd2A10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q04750	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6666222|ensembl:ENSMUSP00000105094|uniprotkb:A2A4B7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:top1_mouse(display_long)|uniprotkb:Top1(gene name)|psi-mi:Top1(display_short)|uniprotkb:Top-1(gene name synonym)|uniprotkb:DNA topoisomerase I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000070544(gene)|ensembl:ENSMUST00000109468(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000932"(P-body)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007059"(chromosome segregation)|go:"GO:0003682"(chromatin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042493"|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097100"(supercoiled DNA binding)|interpro:IPR001631(DNA topoisomerase I, C-terminal)|interpro:IPR008336(DNA topoisomerase I, DNA binding, eukaryotic-type)|interpro:IPR011010(DNA breaking-rejoining enzyme, catalytic core)|interpro:IPR013030(DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type)|interpro:IPR013034(DNA topoisomerase I, DNA binding, alpha helical motif, eukaryotic-type)|interpro:IPR013499(DNA topoisomerase I, C-terminal, eukaryotic-type)|interpro:IPR013500(DNA topoisomerase I, catalytic core, eukaryotic-type)|interpro:IPR014711(DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type)|interpro:IPR014727(DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type)|interpro:IPR018521|interpro:IPR025834|interpro:IPR036202|reactome:R-MMU-4615885|mint:Q04750|refseq:NP_033434.2	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:nY84yAtfGCI/k+B2u3mM151r+zU10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CQJ6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472008|ensembl:ENSMUSP00000023869|uniprotkb:Q3UXY1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:denr_mouse(display_long)|uniprotkb:Denr(gene name)|psi-mi:Denr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000023106(gene)|ensembl:ENSMUST00000023869(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR001950(Translation initiation factor SUI1)|interpro:IPR005873(Density-regulated protein DRP1)|interpro:IPR036877|mint:Q9CQJ6|refseq:NP_080879.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Ng4Exx8ebd9KHHd3492HziiDlIo10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O35671	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26473456|ensembl:ENSMUSP00000075609|ensembl:ENSMUSP00000134627|ensembl:ENSMUSP00000156312|uniprotkb:Q542A8	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:itbp1_mouse(display_long)|uniprotkb:Itgb1bp1(gene name)|psi-mi:Itgb1bp1(display_short)|uniprotkb:Bodenin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000062352(gene)|ensembl:ENSMUST00000076260(transcript)|ensembl:ENSMUST00000173729(transcript)|ensembl:ENSMUST00000232072(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006933"(negative regulation of cell adhesion involved in substrate-bound cell migration)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0016604"(nuclear body)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033622"(integrin activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035148"(tube formation)|go:"GO:0005178"(integrin binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051451"(myoblast migration)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071944"(cell periphery)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090315"(negative regulation of protein targeting to membrane)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR019517|mint:O35671|refseq:NP_032429.1|refseq:XP_006515054.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:jcLVWaKfHFAuQQpip+iWntkN4AQ10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q61074	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-642919|ensembl:ENSMUSP00000031032	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ppm1g_mouse(display_long)|uniprotkb:Protein phosphatase 2C isoform gamma(gene name synonym)|uniprotkb:Protein phosphatase magnesium-dependent 1 gamma(gene name synonym)|uniprotkb:Protein phosphatase 1C(gene name synonym)|uniprotkb:Fibroblast growth factor-inducible protein 13(gene name synonym)|uniprotkb:Ppm1g(gene name)|psi-mi:Ppm1g(display_short)|uniprotkb:Fin13(gene name synonym)|uniprotkb:Ppm1c(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_032040.1|ensembl:ENSMUSG00000029147(gene)|ensembl:ENSMUST00000031032(transcript)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR000222(Protein phosphatase 2C,  manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:Q61074	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:OazpV/JqeZD+TpovURxYWY9t6VI10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P24369	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-494280|ensembl:ENSMUSP00000034947	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ppib_mouse(display_long)|uniprotkb:Cyclophilin B(gene name synonym)|uniprotkb:S-cyclophilin(gene name synonym)|uniprotkb:CYP-S1(gene name synonym)|uniprotkb:Ppib(gene name)|psi-mi:Ppib(display_short)|uniprotkb:Rotamase B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035279.2|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0005737"(cytoplasm)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0060348"(bone development)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR029000|mint:P24369|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0006457"(protein folding)|reactome:R-MMU-1650814|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|ensembl:ENSMUSG00000032383(gene)|ensembl:ENSMUST00000034947(transcript)	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Jp4wVPlfj3WNwhuh/Cvuk1TR7sY10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CQE8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-912160|ensembl:ENSMUSP00000022341	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rtraf_mouse(display_long)|uniprotkb:RTRAF(gene name)|psi-mi:RTRAF(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080804.1|ensembl:ENSMUSG00000021807(gene)|ensembl:ENSMUST00000022341(transcript)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:0072686"(mitotic spindle)|interpro:IPR019265|mint:Q9CQE8	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:AP73IJnWMs4jwKTGnIC+q1GcBRc10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TSC1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-645425|uniprotkb:Q923A9|uniprotkb:Q9Z1R1|ensembl:ENSMUSP00000025253	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:prc2a_mouse(display_long)|uniprotkb:HLA-B-associated transcript 2(gene name synonym)|uniprotkb:Prrc2a(gene name)|psi-mi:Prrc2a(display_short)|uniprotkb:Bat2(gene name synonym)|uniprotkb:Proline-rich and coiled-coil-containing protein 2A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001185973.1|refseq:NP_064411.2|refseq:XP_006524683.1|dip:DIP-49629N|ensembl:ENSMUSG00000024393(gene)|ensembl:ENSMUST00000025253(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030154"(cell differentiation)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:Q7TSC1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ktwyGkClOoaD4rZap/xJb/aKj4s10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80TJ1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-647288|uniprotkb:E9QN90|uniprotkb:Q3TSP2|uniprotkb:Q61374|uniprotkb:Q6AXB4|uniprotkb:Q6PGF0|ensembl:ENSMUSP00000108277	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:caps1_mouse(display_long)|uniprotkb:Calcium-dependent activator protein for secretion 1(gene name synonym)|uniprotkb:Cadps(gene name)|psi-mi:Cadps(display_short)|uniprotkb:Caps(gene name synonym)|uniprotkb:Caps1(gene name synonym)|uniprotkb:Kiaa1121(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001036082.1|refseq:XP_006518098.1|refseq:NP_036191.2|ensembl:ENSMUSG00000054423(gene)|ensembl:ENSMUST00000112658(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0015031"(protein transport)|go:"GO:0016050"(vesicle organization)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031045"(dense core granule)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0050432"(catecholamine secretion)|go:"GO:0098674"(extrinsic component of neuronal dense core vesicle membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099525"(presynaptic dense core vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010439(Protein of unknown function DUF1041)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014770(Munc13 homology 1)|interpro:IPR033227|mint:Q80TJ1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ZvxZwrj+Y7S4PfEUFS4qF4AAPB410090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q61823	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-296473|uniprotkb:P97296|uniprotkb:Q3T9A9|ensembl:ENSMUSP00000025931|ensembl:ENSMUSP00000073975|ensembl:ENSMUSP00000133135	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:pdcd4_mouse(display_long)|uniprotkb:Pdcd4(gene name)|psi-mi:Pdcd4(display_short)|uniprotkb:Ma3(gene name synonym)|uniprotkb:Topoisomerase-inhibitor suppressed protein(gene name synonym)|uniprotkb:Protein MA-3(gene name synonym)|uniprotkb:Tis(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007569"(cell aging)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0060940"(epithelial to mesenchymal transition involved in cardiac fibroblast development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0005829"(cytosol)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|ensembl:ENSMUSG00000024975(gene)|ensembl:ENSMUST00000025931(transcript)|ensembl:ENSMUST00000074371(transcript)|ensembl:ENSMUST00000165617(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039778|mint:Q61823|rcsb pdb:2HM8|rcsb pdb:2IOL|rcsb pdb:2ION|rcsb pdb:2IOS|rcsb pdb:2KZT|rcsb pdb:2NSZ|rcsb pdb:3EIQ|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|refseq:NP_001161963.1|refseq:NP_001161964.1|refseq:NP_035180.2|refseq:XP_006526825.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ruEZtMgfVyIslPFdsTmuOfZhwuM10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80XU3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-5295659|uniprotkb:Q8BVD8|ensembl:ENSMUSP00000062576	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nucks_mouse(display_long)|uniprotkb:Nucks1(gene name)|psi-mi:Nucks1(display_short)|uniprotkb:Nucks(gene name synonym)|uniprotkb:JC7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001139276.1|refseq:NP_780503.2|ensembl:ENSMUSG00000026434(gene)|ensembl:ENSMUST00000062264(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006325"(chromatin organization)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0019046"(release from viral latency)|go:"GO:0031297"(replication fork processing)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0060382"(regulation of DNA strand elongation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990968"(modulation by host of RNA binding by virus)|go:"GO:1990969"(modulation by host of viral RNA-binding transcription factor activity)|interpro:IPR026633|mint:Q80XU3	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:kizDkHbqLwthuDMp8w1hNyLorFw10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q5U3K5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-20313702|uniprotkb:A2AJB0|uniprotkb:Q3TAT5|uniprotkb:Q3TRU4|uniprotkb:Q6PDP8|uniprotkb:Q8BFS4|uniprotkb:Q8CGJ9|ensembl:ENSMUSP00000058746	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rabl6_mouse(display_long)|uniprotkb:GTP-binding protein Parf(gene name synonym)|uniprotkb:Rab-like protein 1(gene name synonym)|uniprotkb:Rabl6(gene name)|psi-mi:Rabl6(display_short)|uniprotkb:Parf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001019787.2|ensembl:ENSMUSG00000015087(gene)|ensembl:ENSMUST00000058137(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|interpro:IPR027417|interpro:IPR040385|mint:Q5U3K5	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:33Z/2FccxqdmaAX5ITh1U0iJdVY10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3U214	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11138104|ensembl:ENSMUSP00000128703|uniprotkb:E9QQ28|uniprotkb:Q6A047	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mast3_mouse(display_long)|uniprotkb:Mast3(gene name)|psi-mi:Mast3(display_short)|uniprotkb:Kiaa0561(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	uniprotkb:E9Q8S5(uniprot-removed-ac)|ensembl:ENSMUSG00000031833(gene)|ensembl:ENSMUST00000166004(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015022(Region of unknown function DUF1908)|interpro:IPR023142|interpro:IPR036034|interpro:IPR037711|interpro:IPR041489|mint:Q3U214|refseq:NP_955012.2|refseq:XP_017168400.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:dnKPSiy4QdeoqkOI4YoyDzjMruU10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q91WJ7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472091|uniprotkb:Q8K322|uniprotkb:Q8VC37	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:sps2l_mouse(display_long)|uniprotkb:Spats2l(gene name)|psi-mi:Spats2l(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|mint:Q91WJ7|refseq:NP_001158038.1|refseq:NP_659131.2|refseq:XP_006496278.1|refseq:XP_006496281.1|interpro:IPR009816(Protein of unknown function DUF1387)|interpro:IPR009060(UBA-like)	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:VhMNvlzLQNyI91NxpTGpOohOwwI10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9JIK5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2551674|uniprotkb:Q3TVJ3|ensembl:ENSMUSP00000042691|uniprotkb:Q9WV45	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ddx21_mouse(display_long)|uniprotkb:Nucleolar RNA helicase II(gene name synonym)|uniprotkb:Nucleolar RNA helicase Gu(gene name synonym)|uniprotkb:RH II/Gu(gene name synonym)|uniprotkb:Gu-alpha(gene name synonym)|uniprotkb:DEAD box protein 21(gene name synonym)|uniprotkb:Ddx21(gene name)|psi-mi:Ddx21(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000020075(gene)|ensembl:ENSMUST00000045866(transcript)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0019843"(rRNA binding)|go:"GO:0030515"(snoRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0062176"(R-loop disassembly)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012562(GUCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR035979|mint:Q9JIK5|rcsb pdb:3ZIN|reactome:R-MMU-5250924|reactome:R-MMU-6791226|go:"GO:0051607"(defense response to virus)|refseq:NP_062426.2|dip:DIP-48574N	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:VMHd6Qxsw72ljg+FE39/O559ynI10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TSH8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472811|ensembl:ENSMUSP00000091440|ensembl:ENSMUSP00000099322|uniprotkb:B1AT99|uniprotkb:Q80U66|uniprotkb:Q8BL05|uniprotkb:Q8K0Q0|uniprotkb:Q91VY1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tmm94_mouse(display_long)|uniprotkb:Tmem94(gene name)|psi-mi:Tmem94(display_short)|uniprotkb:Kiaa0195(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000020747(gene)|ensembl:ENSMUST00000093912(transcript)|ensembl:ENSMUST00000103033(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR023298|interpro:IPR039720|mint:Q7TSH8|refseq:NP_082290.2|refseq:XP_006534334.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:SezB013NdM523ZcLeFSR4GlwMrY10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9Z2W1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-3388705|uniprotkb:Q6IR17|ensembl:ENSMUSP00000027498	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:stk25_mouse(display_long)|uniprotkb:Stk25(gene name)|psi-mi:Stk25(display_short)|uniprotkb:Sok1(gene name synonym)|uniprotkb:Ste20-like kinase(gene name synonym)|uniprotkb:Sterile 20/oxidant stress-response kinase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000026277(gene)|ensembl:ENSMUST00000027498(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035060|mint:Q9Z2W1|refseq:NP_067512.3|refseq:XP_006529831.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:FZeoSpJwXMEK4IOfJ9v3VqM9c+M10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P34152	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-77070|uniprotkb:Q5DTH7|uniprotkb:Q8C513|uniprotkb:Q8CFH7|uniprotkb:Q8CHM2|uniprotkb:Q8K2S0|uniprotkb:Q9DAW3|intact:EBI-644981|uniprotkb:O08578|ensembl:ENSMUSP00000105663	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:fak1_mouse(display_long)|uniprotkb:Ptk2(gene name)|psi-mi:Ptk2(display_short)|uniprotkb:Fadk(gene name synonym)|uniprotkb:Fak(gene name synonym)|uniprotkb:Fak1(gene name synonym)|uniprotkb:Kiaa4203(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001123881.1|refseq:NP_032008.2|refseq:XP_006520496.1|dip:DIP-31045N|ensembl:ENSMUSG00000022607(gene)|ensembl:ENSMUST00000110036(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001764"(neuron migration)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007097"(nuclear migration)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:P34152|rcsb pdb:1K40|rcsb pdb:1KKY|rcsb pdb:1KL0|rcsb pdb:5F28|rcsb pdb:6BZ3|reactome:R-MMU-111465|reactome:R-MMU-2029482|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-375165|reactome:R-MMU-3928662|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-8874081|reactome:R-MMU-9009391	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ZO/rmkDeJv5vec4ug3C3YrIwSIM10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P13864	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-301927|uniprotkb:Q80ZU3|uniprotkb:Q9CSC6|uniprotkb:P97413|uniprotkb:Q9QXX6|ensembl:ENSMUSP00000004202	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dnmt1_mouse(display_long)|uniprotkb:Dnmt1(gene name)|psi-mi:Dnmt1(display_short)|uniprotkb:Dnmt(gene name synonym)|uniprotkb:Met1(gene name synonym)|uniprotkb:Uim(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase MmuI(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001186360.2|refseq:NP_001186361.1|refseq:NP_001186362.1|refseq:NP_034196.5|interpro:IPR031303|interpro:IPR043151|mint:P13864|rcsb pdb:3AV4|rcsb pdb:3AV5|rcsb pdb:3AV6|rcsb pdb:3PT6|rcsb pdb:3PT9|rcsb pdb:4DA4|rcsb pdb:5GUT|rcsb pdb:5GUV|rcsb pdb:5WY1|rcsb pdb:6W8V|rcsb pdb:6W8W|reactome:R-MMU-212300|reactome:R-MMU-4655427|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|ensembl:ENSMUST00000004202(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010424"(DNA methylation on cytosine within a CG sequence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0044026"(DNA hypermethylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046500"(S-adenosylmethionine metabolic process)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051718"("DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:0016458"(obsolete gene silencing)|ensembl:ENSMUSG00000004099(gene)|refseq:NP_001300940.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:JgHTnDhDn4nuU6ww3jXfDPq01xY10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99NH2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6299697|uniprotkb:Q58T10|uniprotkb:Q58T11|uniprotkb:Q8CB21	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:pard3_mouse(display_long)|uniprotkb:Pard3(gene name)|psi-mi:Pard3(display_short)|uniprotkb:Par3(gene name synonym)|uniprotkb:Atypical PKC isotype-specific-interacting protein(gene name synonym)|uniprotkb:Ephrin-interacting protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001013598.1|refseq:NP_001013599.1|go:"GO:0008104"(protein localization)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032970"(regulation of actin filament-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043296"(apical junction complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|rcsb pdb:2KOH|rcsb pdb:2KOJ|reactome:R-MMU-2173791|reactome:R-MMU-420029|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003383"(apical constriction)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|dip:DIP-41727N|mint:Q99NH2	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:T32+accBUmq14vv2OXj2mZe9fzQ10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:E9PZ19	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26473425|ensembl:ENSMUSP00000117017|uniprotkb:Q5DU06	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tutlb_mouse(display_long)|uniprotkb:Igsf9b(gene name)|psi-mi:Igsf9b(display_short)|uniprotkb:Kiaa1030(gene name synonym)|uniprotkb:Immunoglobulin superfamily member 9B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000034275(gene)|ensembl:ENSMUST00000133213(transcript)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:0099629"(postsynaptic specialization of symmetric synapse)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|mint:E9PZ19|refseq:NP_001123259.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:6ta4T8I7R7LnfYgycPtO7jGk9Kc10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P57784	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6877081|ensembl:ENSMUSP00000117947|uniprotkb:Q3U7R8|uniprotkb:Q8K2W4|uniprotkb:Q91YW1|uniprotkb:Q9JKQ3	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ru2a_mouse(display_long)|uniprotkb:Snrpa1(gene name)|psi-mi:Snrpa1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000030512(gene)|ensembl:ENSMUST00000153609(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR032675|interpro:IPR044640|mint:P57784|reactome:R-MMU-72163|refseq:NP_067311.4	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:AMQnbw028+3/guP4MfrfDJCFu6s10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CQ21	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26473122|ensembl:ENSMUSP00000100534	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mcts2_mouse(display_long)|uniprotkb:Mcts2(gene name)|psi-mi:Mcts2(display_short)|uniprotkb:Multiple copies T-cell malignancies 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000042814(gene)|ensembl:ENSMUST00000062148(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|interpro:IPR002478(PUA)|interpro:IPR004521(Uncharacterized domain 2)|interpro:IPR015947(PUA-like)|interpro:IPR016437(Translation machinery-associated RNA binding protein, predicted)|interpro:IPR041366|mint:Q9CQ21|refseq:NP_079819.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:tAXDFylr6cVqjmzxXa70I52GsFU10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P36916	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-17171182|ensembl:ENSMUSP00000084450|uniprotkb:E9QPZ9|uniprotkb:Q91Z20	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:gnl1_mouse(display_long)|uniprotkb:GTP-binding protein MMR1(gene name synonym)|uniprotkb:Gnl1(gene name)|psi-mi:Gnl1(display_short)|uniprotkb:Gna-rs1(gene name synonym)|uniprotkb:Mmr1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000024429(gene)|ensembl:ENSMUST00000087200(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0006974"(cellular response to DNA damage stimulus)|interpro:IPR006073(GTP1/OBG)|interpro:IPR027417|interpro:IPR030378|interpro:IPR043358|mint:P36916|refseq:NP_032162.2	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:5GvOQdadvg4RmdDORomaCEW+7cc10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80X50	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11664310|uniprotkb:Q8BIT6|uniprotkb:Q8BIW4|uniprotkb:Q8BJ01|uniprotkb:Q8CIG7|uniprotkb:Q8K102|uniprotkb:Q9CRT6|ensembl:ENSMUSP00000143459	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ubp2l_mouse(display_long)|uniprotkb:Ubap2l(gene name)|psi-mi:Ubap2l(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001159455.1|refseq:NP_001159456.1|refseq:NP_001159457.1|refseq:NP_001159458.1|refseq:NP_082751.1|refseq:XP_006502235.1|ensembl:ENSMUSG00000042520(gene)|ensembl:ENSMUST00000196843(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031519"(PcG protein complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|mint:Q80X50|rcsb pdb:1WJ7	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ucHEy1MXF7PTEdwLChr6zAOqtcM10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CQ10	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2554069|uniprotkb:Q9D7A5|uniprotkb:Q9D2Z2|ensembl:ENSMUSP00000068410|ensembl:ENSMUSP00000109815	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:chmp3_mouse(display_long)|uniprotkb:Chmp3(gene name)|psi-mi:Chmp3(display_short)|uniprotkb:Chromatin-modifying protein 3(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 24(gene name synonym)|uniprotkb:Vps24(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080059.2|ensembl:ENSMUSG00000053119(gene)|ensembl:ENSMUST00000059462(transcript)|ensembl:ENSMUST00000065364(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0030496"(midbody)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:0031902"(late endosome membrane)|interpro:IPR005024(Snf7)|go:"GO:0032467"(positive regulation of cytokinesis)|mint:Q9CQ10|reactome:R-MMU-1632852|reactome:R-MMU-5620971|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|reactome:R-MMU-917729|reactome:R-MMU-9668328|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051258"(protein polymerization)|go:"GO:0061763"(multivesicular body-lysosome fusion)|go:"GO:0061952"(midbody abscission)|go:"GO:1902187"	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:b52oV5XLyniABacZtbbmaLqKd3M10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P32067	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-911168|ensembl:ENSMUSP00000088365|ensembl:ENSMUSP00000130313	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:la_mouse(display_long)|uniprotkb:La ribonucleoprotein(gene name synonym)|uniprotkb:La autoantigen homolog(gene name synonym)|uniprotkb:Ssb(gene name)|psi-mi:Ssb(display_short)|uniprotkb:Ss-b(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000068882(gene)|ensembl:ENSMUST00000090852(transcript)|ensembl:ENSMUST00000166411(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001682"(tRNA 5'-leader removal)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0008033"(tRNA processing)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042780"(tRNA 3'-end processing)|go:"GO:0071045"(nuclear histone mRNA catabolic process)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002344(Lupus La protein)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR014886(RNA binding motif)|interpro:IPR035979|interpro:IPR036388|interpro:IPR036390|mint:P32067|refseq:NP_001103615.1|refseq:NP_033304.1|dip:DIP-37706N	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:egWOrzRVef4SX0jdKpzPTWEzrjQ10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:A2AN08	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-4285947|uniprotkb:A2AN07|uniprotkb:A2AN09|uniprotkb:A2AN10|uniprotkb:A2AN11|uniprotkb:Q52KI4|uniprotkb:Q6PB49|uniprotkb:Q6PFC7|uniprotkb:Q80Y11|uniprotkb:Q8BGB9|uniprotkb:Q8C3E8|uniprotkb:Q8C4W5|uniprotkb:Q8C8X7|uniprotkb:Q8CGE0|uniprotkb:Q8CHF3|ensembl:ENSMUSP00000095433	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ubr4_mouse(display_long)|uniprotkb:Kiaa0462(gene name synonym)|uniprotkb:Zubr1(gene name synonym)|uniprotkb:N-recognin-4(gene name synonym)|uniprotkb:Ubr4(gene name)|psi-mi:Ubr4(display_short)|uniprotkb:Zinc finger UBR1-type protein 1(gene name synonym)|uniprotkb:p600(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001153791.1|dip:DIP-61499N|ensembl:ENSMUSG00000066036(gene)|ensembl:ENSMUST00000097822(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025704|interpro:IPR036322|mint:A2AN08|reactome:R-MMU-6798695|reactome:R-MMU-983168|go:"GO:0016021"(integral component of membrane)	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:dTpQoZkH0+rwfrguOvzwrbPh0+Y10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6DID3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11519660|uniprotkb:Q3TTX6|uniprotkb:Q5U5V8|uniprotkb:Q80TJ3|uniprotkb:Q8C037|ensembl:ENSMUSP00000076024	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:scaf8_mouse(display_long)|uniprotkb:RNA-binding motif protein 16(gene name synonym)|uniprotkb:Scaf8(gene name)|psi-mi:Scaf8(display_short)|uniprotkb:Kiaa1116(gene name synonym)|uniprotkb:Rbm16(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_598884.2|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005849"(mRNA cleavage factor complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006369"(termination of RNA polymerase II transcription)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006397"(mRNA processing)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043175"(RNA polymerase core enzyme binding)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|go:"GO:2000805"("negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled")|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006569(Regulation of nuclear pre-mRNA protein)|interpro:IPR008942(ENTH/VHS)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034370|interpro:IPR035979|mint:Q6DID3|go:"GO:0005634"(nucleus)|ensembl:ENSMUSG00000046201(gene)|ensembl:ENSMUST00000076734(transcript)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:JL0UMm8YNeOOvy6ZCB3XKR0gHdE10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9QYH6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-1801274|uniprotkb:Q543L6|uniprotkb:Q99PB5|uniprotkb:Q9CYX1|ensembl:ENSMUSP00000026142	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:magd1_mouse(display_long)|uniprotkb:Maged1(gene name)|psi-mi:Maged1(display_short)|uniprotkb:Nrage(gene name synonym)|uniprotkb:MAGE-D1 antigen(gene name synonym)|uniprotkb:Neurotrophin receptor-interacting MAGE homolog(gene name synonym)|uniprotkb:Dlxin-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_062765.1|interpro:IPR041898|interpro:IPR041899|mint:Q9QYH6|ensembl:ENSMUSG00000025151(gene)|ensembl:ENSMUST00000026142(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR002190(MAGE protein)|interpro:IPR030083|interpro:IPR037445	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:yQjDWQnoyOmw1R+BGkK3EO5blik10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8BYZ1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26473401|ensembl:ENSMUSP00000061893|uniprotkb:Q3TA46|uniprotkb:Q6PE63|uniprotkb:Q9D7S4	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:abi3_mouse(display_long)|uniprotkb:Abi3(gene name)|psi-mi:Abi3(display_short)|uniprotkb:Nesh(gene name synonym)|uniprotkb:New molecule including SH3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000018381(gene)|ensembl:ENSMUST00000059026(transcript)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0005737"(cytoplasm)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031209"(SCAR complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028455|interpro:IPR028457|interpro:IPR036028|mint:Q8BYZ1|refseq:NP_001156936.1|refseq:NP_079935.1|refseq:XP_017170199.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:JJhI2DN2m/wvplOjOnhoLLvG2yM10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:A2CG63	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6394082|ensembl:ENSMUSP00000106163|uniprotkb:A2CG61|uniprotkb:A2CG62|uniprotkb:A2CG64|uniprotkb:B2RQ67|uniprotkb:Q8BMI8|uniprotkb:Q8BYA5	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ari4b_mouse(display_long)|uniprotkb:Arid4b(gene name)|psi-mi:Arid4b(display_short)|uniprotkb:Sap180(gene name synonym)|uniprotkb:180 kDa Sin3-associated polypeptide(gene name synonym)|uniprotkb:Histone deacetylase complex subunit SAP180(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000039219(gene)|ensembl:ENSMUST00000110534(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0034773"(histone H4-K20 trimethylation)|go:"GO:0036124"(histone H3-K9 trimethylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097368"(establishment of Sertoli cell barrier)|interpro:IPR002999(Tudor)|interpro:IPR012603(RBB1NT)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR028853|interpro:IPR036431|mint:A2CG63|reactome:R-MMU-3214815|interpro:IPR001606(AT-rich interaction region)|refseq:XP_006516869.1|refseq:XP_006516870.1|refseq:NP_919238.1|refseq:NP_937755.1|refseq:XP_017171137.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:PFHXddI4KDF7QPdrbBYPTFymTQA10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3UH68	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16731192|ensembl:ENSMUSP00000098723|uniprotkb:Q6DIC3|uniprotkb:Q80TK1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:limc1_mouse(display_long)|uniprotkb:Limch1(gene name)|psi-mi:Limch1(display_short)|uniprotkb:Kiaa1102(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000037736(gene)|ensembl:ENSMUST00000101164(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032034"(myosin II head/neck binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0060327"(cytoplasmic actin-based contraction involved in cell motility)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR001997(Calponin)|interpro:IPR029980|interpro:IPR031865|interpro:IPR036872|mint:Q3UH68|refseq:NP_001001980.2|refseq:NP_001243051.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:P8I5hZ1jOyZUpClXSiMeTpic7AQ10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P51432	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2606131|uniprotkb:Q3UIS0|ensembl:ENSMUSP00000025912	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:plcb3_mouse(display_long)|uniprotkb:Plcb3(gene name)|psi-mi:Plcb3(display_short)|uniprotkb:Phosphoinositide phospholipase C-beta-3(gene name synonym)|uniprotkb:Phospholipase C-beta-3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001277278.1|refseq:NP_032900.2|ensembl:ENSMUSG00000024960(gene)|ensembl:ENSMUST00000025912(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0032957"(inositol trisphosphate metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0031161"(phosphatidylinositol catabolic process)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0099524"(postsynaptic cytosol)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR011992(EF-Hand type)|interpro:IPR014815(PLC-beta, C-terminal)|interpro:IPR015359(Phospholipase C, phosphoinositol-specific, EF-hand-like)|interpro:IPR016280(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta)|interpro:IPR017946|interpro:IPR035892|interpro:IPR037862|interpro:IPR042531|mint:P51432|reactome:R-MMU-112043|reactome:R-MMU-1855204|reactome:R-MMU-399997|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-418217|reactome:R-MMU-434316|reactome:R-MMU-500657	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:QLv9VwdghXWe7hlfN9JAV23z9oU10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9JJY4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-944496|uniprotkb:Q059Z6|uniprotkb:Q9JIK4|ensembl:ENSMUSP00000088176	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ddx20_mouse(display_long)|uniprotkb:Ddx20(gene name)|psi-mi:Ddx20(display_short)|uniprotkb:Dp103(gene name synonym)|uniprotkb:Gemin3(gene name synonym)|uniprotkb:DEAD box protein 20(gene name synonym)|uniprotkb:DEAD box protein DP 103(gene name synonym)|uniprotkb:Component of gems 3(gene name synonym)|uniprotkb:Gemin-3(gene name synonym)|uniprotkb:Regulator of steroidogenic factor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_059093.3|refseq:XP_006501764.1|ensembl:ENSMUSG00000027905(gene)|ensembl:ENSMUST00000090680(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032797"(SMN complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048477"(oogenesis)|go:"GO:0050810"(regulation of steroid biosynthetic process)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0097504"(Gemini of coiled bodies)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q9JJY4|reactome:R-MMU-191859	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:qoEKTrnCV+OBWfbeNBdVTUHAArU10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3UHD6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6910393|ensembl:ENSMUSP00000102904|uniprotkb:Q7TQL6|uniprotkb:Q80TZ1|uniprotkb:Q9CYB5	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:snx27_mouse(display_long)|uniprotkb:Snx27(gene name)|psi-mi:Snx27(display_short)|uniprotkb:Kiaa0488(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0006886"(intracellular protein transport)|go:"GO:0007165"(signal transduction)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016197"(endosomal transport)|go:"GO:0030904"(retromer complex)|ensembl:ENSMUSG00000028136(gene)|ensembl:ENSMUST00000107283(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0071203"(WASH complex)|go:"GO:0005768"(endosome)|go:"GO:0099638"(endosome to plasma membrane protein transport)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|interpro:IPR000159(Ras-association)|interpro:IPR001478(PDZ/DHR/GLGF)|go:"GO:0005769"(early endosome)|interpro:IPR001683(Phox-like)|interpro:IPR028667|interpro:IPR029071|go:"GO:0005829"(cytosol)|interpro:IPR036034|go:"GO:0005886"(plasma membrane)|interpro:IPR036871|interpro:IPR037827|interpro:IPR037831|interpro:IPR037833|interpro:IPR037835|mint:Q3UHD6|refseq:NP_001075953.1|refseq:NP_083997.1|dip:DIP-60337N	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:+pFe87lSKQPJuMDWsiMU4iXhGOw10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8BL48	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-643350|uniprotkb:Q8BVI6|uniprotkb:Q99JZ8|uniprotkb:Q99LL9|uniprotkb:A2A853|ensembl:ENSMUSP00000021116	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:unk_mouse(display_long)|uniprotkb:Zinc finger CCCH domain-containing protein 5(gene name synonym)|uniprotkb:Unk(gene name)|psi-mi:Unk(display_short)|uniprotkb:Kiaa1753(gene name synonym)|uniprotkb:Zc3hdc5(gene name synonym)|uniprotkb:Zc3h5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_766157.1|ensembl:ENSMUSG00000020770(gene)|ensembl:ENSMUST00000021116(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0046872"(metal ion binding)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:1905538"(polysome binding)|go:"GO:1990715"(mRNA CDS binding)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR036855|interpro:IPR040594|mint:Q8BL48|rcsb pdb:5ELH|rcsb pdb:5ELK	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:+7BVlzD+jczZ9/NZxDyCx1ZpGpU10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99MR6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6908591|ensembl:ENSMUSP00000043123|uniprotkb:Q3UD04|uniprotkb:Q5D042|uniprotkb:Q8VEE6|uniprotkb:Q99MR4|uniprotkb:Q99MR5|uniprotkb:Q99MR7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:srrt_mouse(display_long)|uniprotkb:Srrt(gene name)|psi-mi:Srrt(display_short)|uniprotkb:Ars2(gene name synonym)|uniprotkb:Asr2(gene name synonym)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_006504692.1|ensembl:ENSMUSG00000037364(gene)|ensembl:ENSMUST00000040873(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007042(Arsenite-resistance protein 2)|interpro:IPR021933|interpro:IPR035979|interpro:IPR039727|mint:Q99MR6|reactome:R-MMU-6807505|reactome:R-MMU-72163|refseq:NP_001103379.1|refseq:NP_001103380.1|refseq:NP_113582.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:bN5sDa7ldVbikff0n+wySOIeGrE10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O35344	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-3043911|ensembl:ENSMUSP00000022496	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ima4_mouse(display_long)|uniprotkb:Kpna3(gene name)|psi-mi:Kpna3(display_short)|uniprotkb:Qip2(gene name synonym)|uniprotkb:Importin alpha Q2(gene name synonym)|uniprotkb:Karyopherin subunit alpha-3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000021929(gene)|ensembl:ENSMUST00000022496(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O35344|go:"GO:0005634"(nucleus)|refseq:NP_032492.1|dip:DIP-62054N	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:n1z2s11CghKCHD+2w6yOGWbpFYE10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6VH22	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-22226681|ensembl:ENSMUSP00000049335|uniprotkb:Q6NZK1|uniprotkb:Q80TI4|uniprotkb:Q80W19|uniprotkb:Q9DAB0	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:if172_mouse(display_long)|uniprotkb:Ift172(gene name)|psi-mi:Ift172(display_short)|uniprotkb:Kiaa1179(gene name synonym)|uniprotkb:Wim(gene name synonym)|uniprotkb:Protein wimple(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0060271"(cilium assembly)|go:"GO:0060348"(bone development)|go:"GO:0061525"(hindgut development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097228"(sperm principal piece)|go:"GO:0097598"(sperm cytoplasmic droplet)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR036322|mint:Q6VH22|reactome:R-MMU-5610787|reactome:R-MMU-5620924|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008544"(epidermis development)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021915"(neural tube development)|go:"GO:0030992"(intraciliary transport particle B)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031514"(motile cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060173"(limb development)|go:"GO:0007368"(determination of left/right symmetry)|ensembl:ENSMUSG00000038564(gene)|ensembl:ENSMUST00000041565(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001841"(neural tube formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|refseq:NP_080574.5	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:qKlWtm735I1OrvYPmj7ZUyI3ZDA10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8C5W0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-774379|uniprotkb:Q91V71|uniprotkb:Q91XT7|uniprotkb:Q91XT8|uniprotkb:Q91XU9|ensembl:ENSMUSP00000105563	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:clmn_mouse(display_long)|uniprotkb:Calponin-like transmembrane domain protein(gene name synonym)|uniprotkb:Clmn(gene name)|psi-mi:Clmn(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001035772.1|refseq:NP_444385.2|ensembl:ENSMUSG00000021097(gene)|ensembl:ENSMUST00000109937(transcript)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0007097"(nuclear migration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0051015"(actin filament binding)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR036872|mint:Q8C5W0	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:+QifozWRqE6NppDc+GPs9Jsm/uQ10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:D3YXK2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-539539|ensembl:ENSMUSP00000092849	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:safb1_mouse(display_long)|uniprotkb:Safb(gene name)|psi-mi:Safb(display_short)|uniprotkb:Safb1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001156772.1|ensembl:ENSMUST00000095224(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030496"(midbody)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0040008"(regulation of growth)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050684"(regulation of mRNA processing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034781|interpro:IPR035979|interpro:IPR036361|mint:D3YXK2|ensembl:ENSMUSG00000071054(gene)|reactome:R-MMU-3899300	-	-	comment:Author screened murine library then identified protein by homology to rat. Currently no murine sequence in database.	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:wGs3hvKUEDoWR83eBl9+qv4JWzs10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80U28	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6271803|uniprotkb:Q3TQK3|uniprotkb:Q6P4I6|uniprotkb:Q80W52|uniprotkb:Q80WL3|uniprotkb:Q80WL4|uniprotkb:Q80WL5|uniprotkb:Q80WL6|uniprotkb:Q80WL7|uniprotkb:Q80WL8|uniprotkb:Q80WL9|uniprotkb:Q80WM0|uniprotkb:Q80WM1|uniprotkb:Q80WM2|uniprotkb:Q8CBC1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:madd_mouse(display_long)|uniprotkb:Rab3 GDP/GTP exchange protein(gene name synonym)|uniprotkb:Madd(gene name)|psi-mi:Madd(display_short)|uniprotkb:Kiaa0358(gene name synonym)|uniprotkb:Rab3 GDP/GTP exchange factor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR037516|mint:Q80U28|refseq:NP_001171190.1|refseq:NP_001171191.1|refseq:NP_663502.3|interpro:IPR005112(dDENN)|interpro:IPR001194(DENN)|interpro:IPR005113(uDENN)|refseq:XP_017173117.1|interpro:IPR039980|interpro:IPR043153|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0032483"(regulation of Rab protein signal transduction)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1902041"(regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902277"(negative regulation of pancreatic amylase secretion)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|reactome:R-MMU-5357905|reactome:R-MMU-8876198|go:"GO:0016021"(integral component of membrane)	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:N1jHLTmvUiVv+sCMbX8Q/nAq7XI10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8K2F8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2554251|uniprotkb:Q9CTG8|ensembl:ENSMUSP00000082723	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ls14a_mouse(display_long)|uniprotkb:Fam61a(gene name synonym)|uniprotkb:Rap55a(gene name synonym)|uniprotkb:Protein FAM61A(gene name synonym)|uniprotkb:RNA-associated protein 55A(gene name synonym)|uniprotkb:Lsm14a(gene name)|psi-mi:Lsm14a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080224.1|ensembl:ENSMUSG00000066568(gene)|ensembl:ENSMUST00000085585(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR019050|interpro:IPR025609|interpro:IPR025761|interpro:IPR025762|interpro:IPR025768|mint:Q8K2F8	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ukJG23hyWin24AD3ZzrcPCeQ6Wg10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q5XJV6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16726286|uniprotkb:A6BLZ0|uniprotkb:Q52KF1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:lmtk3_mouse(display_long)|uniprotkb:Apoptosis-associated tyrosine kinase 3(gene name synonym)|uniprotkb:Lemur tyrosine kinase 3(gene name synonym)|uniprotkb:Lmtk3(gene name)|psi-mi:Lmtk3(display_short)|uniprotkb:Aatyk3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|mint:Q5XJV6|refseq:NP_001005511.2|refseq:NP_001277919.1|refseq:XP_006541027.1|refseq:XP_017177816.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:FJgk1CZB0wgIbl5dhC81Wy7TRJE10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99JY8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-773683|uniprotkb:Q3TVM4|uniprotkb:Q3TXR7|uniprotkb:Q8BTB7|ensembl:ENSMUSP00000065719	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:plpp3_mouse(display_long)|uniprotkb:Plpp3(gene name)|psi-mi:Plpp3(display_short)|uniprotkb:Lipid phosphate phosphohydrolase 3(gene name synonym)|uniprotkb:Lpp3(gene name synonym)|uniprotkb:PAP2-beta(gene name synonym)|uniprotkb:Phosphatidate phosphohydrolase type 2b(gene name synonym)|uniprotkb:Phosphatidic acid phosphatase 2b(gene name synonym)|uniprotkb:Ppap2b(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_542122.1|ensembl:ENSMUSG00000028517(gene)|ensembl:ENSMUST00000064139(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001568"(blood vessel development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005178"(integrin binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006670"(sphingosine metabolic process)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008195"(phosphatidate phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042392"(sphingosine-1-phosphate phosphatase activity)|go:"GO:0042577"(lipid phosphatase activity)|go:"GO:0044328"(canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration)|go:"GO:0044329"(canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion)|go:"GO:0044330"(canonical Wnt signaling pathway involved in positive regulation of wound healing)|go:"GO:0045121"(membrane raft)|go:"GO:0046839"(phospholipid dephosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0106235"(ceramide-1-phosphate phosphatase activity)|go:"GO:1902068"(regulation of sphingolipid mediated signaling pathway)|interpro:IPR000326(Phosphatidic acid phosphatase type 2/haloperoxidase)|interpro:IPR028675|interpro:IPR036938|interpro:IPR043216|mint:Q99JY8|reactome:R-MMU-1660661	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:k0j2BFjYFftNCFSr6/PrQfurHck10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9EPW0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-773431|uniprotkb:Q8CBJ8	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:inp4a_mouse(display_long)|uniprotkb:Inositol polyphosphate 4-phosphatase type I(gene name synonym)|uniprotkb:Inpp4a(gene name)|psi-mi:Inpp4a(display_short)|uniprotkb:Inositol polyphosphate 4-phosphatase-1(gene name synonym)|uniprotkb:Type I inositol 3,4-bisphosphate 4-phosphatase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001277726.1|refseq:NP_001277727.1|refseq:NP_001277728.1|refseq:NP_084542.2|refseq:NP_766559.2|interpro:IPR039034|mint:Q9EPW0|interpro:IPR035892|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006798"(polyphosphate catabolic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016316"(phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity)|go:"GO:0017161"(inositol-1,3,4-trisphosphate 4-phosphatase activity)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034597"(phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity)|go:"GO:0052828"(inositol-3,4-bisphosphate 4-phosphatase activity)|go:"GO:0055038"(recycling endosome membrane)|reactome:R-MMU-1660499|reactome:R-MMU-1660516|reactome:R-MMU-1855183|interpro:IPR000008(C2 calcium-dependent membrane targeting)	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:l/ZBtTwMJFCdvrqsTa7Nz/3tbpo10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80WG5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-20718010|ensembl:ENSMUSP00000092690|ensembl:ENSMUSP00000109284|ensembl:ENSMUSP00000139038|uniprotkb:A2AQZ0	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:lrc8a_mouse(display_long)|uniprotkb:Protein ebouriffe(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 8A(gene name synonym)|uniprotkb:Lrrc8a(gene name)|psi-mi:Lrrc8a(display_short)|uniprotkb:Lrrc8(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000099041(gene)|ensembl:ENSMUST00000095078(transcript)|ensembl:ENSMUST00000113654(transcript)|ensembl:ENSMUST00000139454(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002329"(pre-B cell differentiation)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0015734"(taurine transport)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034702"(ion channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0098656"(anion transmembrane transport)|go:"GO:0140360"(cyclic-GMP-AMP transmembrane transporter activity)|go:"GO:0140361"(cyclic-GMP-AMP transmembrane import across plasma membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|ensembl:ENSMUSG00000007476(gene)|interpro:IPR021040|interpro:IPR032675|mint:Q80WG5|rcsb pdb:6FNW|rcsb pdb:6G8Z|rcsb pdb:6G9L|rcsb pdb:6G9O|rcsb pdb:6NZW|rcsb pdb:6NZZ|rcsb pdb:6O00|rcsb pdb:7M17|rcsb pdb:7M19|reactome:R-MMU-5223345|refseq:NP_808393.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:a39hFvsEXuauN4cwEgT+rKHU3oo10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q05CL8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6260966|ensembl:ENSMUSP00000029588|uniprotkb:Q8VDW3|uniprotkb:Q9CUQ5|uniprotkb:Q3TSC2|uniprotkb:Q9CSI9|uniprotkb:Q8K2Y6|uniprotkb:Q9CSI2	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:larp7_mouse(display_long)|uniprotkb:D3Wsu161e(gene name synonym)|uniprotkb:La ribonucleoprotein domain family member 7(gene name synonym)|uniprotkb:Larp7(gene name)|psi-mi:Larp7(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000027968(gene)|ensembl:ENSMUST00000029588(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000494"(box C/D RNA 3'-end processing)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008380"(RNA splicing)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0036093"(germ cell proliferation)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0120259"(7SK snRNP)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1905382"(positive regulation of snRNA transcription by RNA polymerase II)|go:"GO:1990438"(U6 2'-O-snRNA methylation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002344(Lupus La protein)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR014886(RNA binding motif)|interpro:IPR034887|interpro:IPR034910|interpro:IPR034946|interpro:IPR035979|interpro:IPR036388|interpro:IPR036390|mint:Q05CL8|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_613059.2	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:LXPfM/sQrPvcSwU7ti5T93JQ6+k10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CCJ3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11104902|uniprotkb:Q9D8I8|uniprotkb:Q3V145|uniprotkb:Q6ZQ50|uniprotkb:Q8BT70|uniprotkb:Q8C484|uniprotkb:B1AXU5|uniprotkb:B1AXU6|uniprotkb:A2RSP7|ensembl:ENSMUSP00000100059	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ufl1_mouse(display_long)|uniprotkb:Ufl1(gene name)|psi-mi:Ufl1(display_short)|uniprotkb:Maxer(gene name synonym)|uniprotkb:Kiaa0776(gene name synonym)|uniprotkb:Multiple alpha-helix protein located at ER(gene name synonym)|uniprotkb:E3 UFM1-protein transferase 1(gene name synonym)|uniprotkb:Rcad(gene name synonym)|uniprotkb:Regulator of C53/LZAP and DDRGK1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080470.2|refseq:XP_006538266.1|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016570"(histone modification)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0061666"(UFM1 ligase activity)|go:"GO:0061709"(reticulophagy)|go:"GO:0071568"(UFM1 transferase activity)|go:"GO:0071569"(protein ufmylation)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1990592"(protein K69-linked ufmylation)|interpro:IPR018611|mint:Q8CCJ3|reactome:R-MMU-983168|ensembl:ENSMUSG00000040359(gene)|ensembl:ENSMUST00000102994(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:x++eVmlPuV0sDnDotvzl8EDfU7k10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9WTT4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6273387|ensembl:ENSMUSP00000069482	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:vatg2_mouse(display_long)|uniprotkb:Atp6v1g2(gene name)|psi-mi:Atp6v1g2(display_short)|uniprotkb:Atp6g2(gene name synonym)|uniprotkb:Ng38(gene name synonym)|uniprotkb:V-ATPase 13 kDa subunit 2(gene name synonym)|uniprotkb:Vacuolar proton pump subunit G 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000024403(gene)|ensembl:ENSMUST00000068261(transcript)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0042470"(melanosome)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|interpro:IPR005124("Vacuolar (H+)-ATPase G subunit")|mint:Q9WTT4|reactome:R-MMU-1222556|reactome:R-MMU-77387|reactome:R-MMU-917977|reactome:R-MMU-9639288|reactome:R-MMU-983712|refseq:NP_001334280.1|refseq:NP_075668.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:IGtYI45kRT49q4bPMtZMCJowYKs10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q5DU41	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471671|ensembl:ENSMUSP00000108327|uniprotkb:B2RSI6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:lrc8b_mouse(display_long)|uniprotkb:Lrrc8b(gene name)|psi-mi:Lrrc8b(display_short)|uniprotkb:Kiaa0231(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 8B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000070639(gene)|ensembl:ENSMUST00000112707(transcript)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0034702"(ion channel complex)|go:"GO:0098656"(anion transmembrane transport)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR021040|interpro:IPR032675|mint:Q5DU41|reactome:R-MMU-5223345|refseq:NP_001028722.1|refseq:XP_011247810.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:pIaVtAr+oH3iytnXJ5lubI8K0XY10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8C3Q5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16733755|ensembl:ENSMUSP00000064886|uniprotkb:Q3UMB3|uniprotkb:A0A172Q401|uniprotkb:A0A172Q418	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:shsa7_mouse(display_long)|uniprotkb:"GABA(A) receptor auxiliary subunit Shisa7"(gene name synonym)|uniprotkb:Shisa7(gene name)|psi-mi:Shisa7(display_short)|uniprotkb:Cystine-knot AMPAR modulating protein of 59 kDa(gene name synonym)|uniprotkb:Shisa family member 7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0106040"(regulation of GABA-A receptor activity)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|interpro:IPR026910|mint:Q8C3Q5|ensembl:ENSMUSG00000053550(gene)|ensembl:ENSMUST00000066041(transcript)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007613"(memory)|go:"GO:0014069"(postsynaptic density)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098985"(asymmetric, glutamatergic, excitatory synapse)|refseq:NP_001277220.1|refseq:NP_766325.3|refseq:XP_006539838.1|refseq:XP_011248805.1|refseq:XP_017177636.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:QLd4YuqeuHEYoMVMriatA4ix1Vg10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80ZF8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16724676|ensembl:ENSMUSP00000035612|ensembl:ENSMUSP00000116231|ensembl:ENSMUSP00000119804|uniprotkb:G3XA05	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:agrb3_mouse(display_long)|uniprotkb:Brain-specific angiogenesis inhibitor 3(gene name synonym)|uniprotkb:Adgrb3(gene name)|psi-mi:Adgrb3(display_short)|uniprotkb:Bai3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000033569(gene)|ensembl:ENSMUST00000041838(transcript)|ensembl:ENSMUST00000135518(transcript)|ensembl:ENSMUST00000151309(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0043083"(synaptic cleft)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0061743"(motor learning)|go:"GO:0098794"(postsynapse)|go:"GO:0099558"(maintenance of synapse structure)|interpro:IPR000203(GPS)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR008077(GPCR, family 2, brain-specific angiogenesis inhibitor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR032471|interpro:IPR036383|interpro:IPR036445|interpro:IPR043838|mint:Q80ZF8|refseq:NP_783573.4	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:gSLNnlXd3ua1ax9MiKbUQTHz/yQ10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9JKC8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-9085473|uniprotkb:Q5BKQ6|ensembl:ENSMUSP00000117346	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ap3m1_mouse(display_long)|uniprotkb:Ap3m1(gene name)|psi-mi:Ap3m1(display_short)|uniprotkb:Mu-adaptin 3A(gene name synonym)|uniprotkb:Mu3A-adaptin(gene name synonym)|uniprotkb:AP-3 adaptor complex mu3A subunit(gene name synonym)|uniprotkb:Adaptor-related protein complex 3 subunit mu-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_061299.3|refseq:XP_006519355.1|refseq:XP_006519356.1|ensembl:ENSMUSG00000021824(gene)|ensembl:ENSMUST00000154460(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|mint:Q9JKC8	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:tRkT0Uc0llSqmu/AFSjaLSqREg010090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3U0M1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6160720|uniprotkb:Q3UU81|uniprotkb:Q69Z79|uniprotkb:Q6NS50|uniprotkb:Q8CD01|uniprotkb:Q8CFV8|uniprotkb:Q9D8R6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tppc9_mouse(display_long)|uniprotkb:Trappc9(gene name)|psi-mi:Trappc9(display_short)|uniprotkb:Kiaa1882(gene name synonym)|uniprotkb:Nibp(gene name synonym)|uniprotkb:NIK- and IKBKB-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	mint:Q3U0M1|refseq:NP_001158113.1|refseq:NP_001158114.1|refseq:NP_001158115.1|refseq:NP_083916.1|refseq:NP_850993.2|interpro:IPR013935(Transport protein Trs120)|refseq:XP_006521590.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030008"(TRAPP complex)|go:"GO:0030182"(neuron differentiation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|reactome:R-MMU-204005|reactome:R-MMU-8876198	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:4o6Vzu9Mu9hWN7CZ+ifMfOffaGk10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8C2E7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-15483746|ensembl:ENSMUSP00000022976|uniprotkb:Q8BGY1|uniprotkb:Q8K2J2	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:wasc5_mouse(display_long)|uniprotkb:Washc5(gene name)|psi-mi:Washc5(display_short)|uniprotkb:Kiaa0196(gene name synonym)|uniprotkb:WASH complex subunit strumpellin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000022350(gene)|ensembl:ENSMUST00000022976(transcript)|go:"GO:0001556"(oocyte maturation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0034629"|go:"GO:0040038"(polar body extrusion after meiotic divisions)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043933"(protein-containing complex organization)|go:"GO:0051125"(regulation of actin nucleation)|go:"GO:0071203"(WASH complex)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0140285"(endosome fission)|interpro:IPR019393|mint:Q8C2E7|go:"GO:0042632"(cholesterol homeostasis)|refseq:NP_705776.2	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:8sJZNUfe6xELTIE/9I62bWYwrWk10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9WTU3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6396042|uniprotkb:Q3TYI3|uniprotkb:Q60828|uniprotkb:Q60858|uniprotkb:Q62449	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:scn8a_mouse(display_long)|uniprotkb:Scn8a(gene name)|psi-mi:Scn8a(display_short)|uniprotkb:Nbna1(gene name synonym)|uniprotkb:Sodium channel protein type VIII subunit alpha(gene name synonym)|uniprotkb:Voltage-gated sodium channel subunit alpha Nav1.6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0001518"(voltage-gated sodium channel complex)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007517"(muscle organ development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031402"(sodium ion binding)|go:"GO:0033268"(node of Ranvier)|go:"GO:0034706"(sodium channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043194"(axon initial segment)|go:"GO:0050905"(neuromuscular process)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|rcsb pdb:3WFN|reactome:R-MMU-5576892|mint:Q9WTU3|interpro:IPR044564|interpro:IPR027359|interpro:IPR024583|interpro:IPR005821(Ion transport)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR008054(Na+ channel 8)|interpro:IPR001696(Na+ channel)|interpro:IPR010526(Sodium ion transport-associated)|refseq:NP_001070967.1|refseq:NP_035453.2|interpro:IPR043203	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:unNA0jT1D+rVCXv6xsuveXffeHg10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P07934	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470873|ensembl:ENSMUSP00000026617	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:phkg1_mouse(display_long)|uniprotkb:Phkg1(gene name)|psi-mi:Phkg1(display_short)|uniprotkb:Phkg(gene name synonym)|uniprotkb:Phosphorylase kinase subunit gamma-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PHKG1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000026617(transcript)|go:"GO:0004689"(phosphorylase kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR002291(Phosphorylase kinase, gamma catalytic subunit)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P07934|reactome:R-MMU-70221|ensembl:ENSMUSG00000025537(gene)|refseq:NP_035209.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:oWhiqhcqtIelRPU5Z0TI4T9lskc10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TQH0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6908203|ensembl:ENSMUSP00000035415|uniprotkb:Q80XN9|uniprotkb:Q8K059	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:atx2l_mouse(display_long)|uniprotkb:Atxn2l(gene name)|psi-mi:Atxn2l(display_short)|uniprotkb:A2lp(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_006507788.1|ensembl:ENSMUSG00000032637(gene)|ensembl:ENSMUST00000040202(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010603"(regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0034063"(stress granule assembly)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR025852|mint:Q7TQH0|refseq:NP_898841.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:7v7iuPRti2err2QrmJIGoWqEM3U10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3UHK6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-773013|uniprotkb:O70465|uniprotkb:Q3TSI0|uniprotkb:Q3UH52|uniprotkb:Q80TF5|uniprotkb:Q9WTS7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ten4_mouse(display_long)|uniprotkb:Tenm4(gene name)|psi-mi:Tenm4(display_short)|uniprotkb:Doc4(gene name synonym)|uniprotkb:Downstream of CHOP4(gene name synonym)|uniprotkb:Kiaa1302(gene name synonym)|uniprotkb:Odz4(gene name synonym)|uniprotkb:Protein Odd Oz/ten-m homolog 4(gene name synonym)|uniprotkb:Tenascin-M4(gene name synonym)|uniprotkb:Teneurin transmembrane protein 4(gene name synonym)|uniprotkb:Tnm4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR031325|refseq:NP_001297689.1|refseq:NP_001297691.1|refseq:NP_035988.2|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR008969(Carboxypeptidase-like, regulatory region)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR013111(EGF, extracellular)|interpro:IPR022385|interpro:IPR009471(Teneurin intracellular, N-terminal)|interpro:IPR006530(YD repeat)|interpro:IPR028916|refseq:XP_017177717.1|interpro:IPR027691|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048666"(neuron development)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060912"(cardiac cell fate specification)|go:"GO:2000543"(positive regulation of gastrulation)|mint:Q3UHK6	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:0oVMre4l1F1JwL4Gu0Uz8P2bDew10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q69ZS7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16114976|ensembl:ENSMUSP00000151689|uniprotkb:Q91Z32|uniprotkb:Q9CVT2|uniprotkb:Q9CZ95|uniprotkb:Q9WTY5	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:hbs1l_mouse(display_long)|uniprotkb:Hbs1l(gene name)|psi-mi:Hbs1l(display_short)|uniprotkb:Hbs1(gene name synonym)|uniprotkb:Kiaa1038(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000019977(gene)|ensembl:ENSMUST00000219915(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0006412"(translation)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR015033(Region of unknown function DUF1916)|interpro:IPR027417|interpro:IPR037189|mint:Q69ZS7|rcsb pdb:1UFZ|reactome:R-MMU-429958|refseq:NP_062676.2|dip:DIP-61684N	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:dd3V35ypdOSf9gmD44D6F6Nv6Qo10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P80316	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-772379|uniprotkb:Q3TIE0|uniprotkb:Q3U530|uniprotkb:Q3UCU4|uniprotkb:Q3UJK9|uniprotkb:Q3UWA9|uniprotkb:Q542K3|uniprotkb:Q6ZQJ1|ensembl:ENSMUSP00000022842	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tcpe_mouse(display_long)|uniprotkb:CCT-epsilon(gene name synonym)|uniprotkb:Cct5(gene name)|psi-mi:Cct5(display_short)|uniprotkb:Ccte(gene name synonym)|uniprotkb:Kiaa0098(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_031663.1|refseq:NP_001334964.1|ensembl:ENSMUSG00000022234(gene)|ensembl:ENSMUST00000022842(transcript)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0009615"(response to virus)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012718(T-complex protein 1, epsilon subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P80316|reactome:R-MMU-390471|reactome:R-MMU-5620922|reactome:R-MMU-6814122	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:UpEEjKLyd92Zl4VnOTTlziuwAGA10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P42208	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-772099|uniprotkb:Q3U9Y5|uniprotkb:B2RRZ2|ensembl:ENSMUSP00000027495|ensembl:ENSMUSP00000132850|ensembl:ENSMUSP00000136366	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:sept2_mouse(display_long)|uniprotkb:Sept2(gene name synonym)|uniprotkb:Septin2(gene name)|psi-mi:Septin2(display_short)|uniprotkb:Nedd5(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001153189.1|refseq:NP_001153190.1|refseq:NP_001153191.1|refseq:NP_035021.1|refseq:XP_006529304.1|refseq:XP_006529305.1|dip:DIP-32438N|ensembl:ENSMUSG00000026276(gene)|ensembl:ENSMUSG00000116048(gene)|ensembl:ENSMUST00000027495(transcript)|ensembl:ENSMUST00000168776(transcript)|ensembl:ENSMUST00000179353(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0000776"(kinetochore)|go:"GO:0002036"(regulation of L-glutamate import across plasma membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005930"(axoneme)|go:"GO:0005938"(cell cortex)|go:"GO:0005940"(septin ring)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030496"(midbody)|go:"GO:0031105"(septin complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051258"(protein polymerization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0097227"(sperm annulus)|go:"GO:0097730"(non-motile cilium)|interpro:IPR008113(Septin 2)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|rcsb pdb:3FTQ|reactome:R-MMU-5620912|mint:P42208	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:vk7UVRzpfbNxL4cxXJhd94mfQxc10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CHT1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-911398|uniprotkb:Q8R204|uniprotkb:Q923H2|uniprotkb:Q9JHT9	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ngef_mouse(display_long)|uniprotkb:Eph-interacting exchange protein(gene name synonym)|uniprotkb:Neuronal guanine nucleotide exchange factor(gene name synonym)|uniprotkb:Ngef(gene name)|psi-mi:Ngef(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0030154"(cell differentiation)|go:"GO:0030426"(growth cone)|mint:Q8CHT1|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|reactome:R-MMU-193648|reactome:R-MMU-3928663|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007399"(nervous system development)|go:"GO:0009987"(cellular process)|go:"GO:0016020"(membrane)|refseq:NP_001104784.1|refseq:NP_063920.2|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|interpro:IPR035635|interpro:IPR035899|interpro:IPR036028	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:6KDlJ/WWKhZ/Gpd3JjtniKfRIiQ10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:A2A690	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16733043|ensembl:ENSMUSP00000097904|uniprotkb:A2A683|uniprotkb:Q3TRZ3|uniprotkb:Q5EBP6|uniprotkb:Q69ZQ7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tanc2_mouse(display_long)|uniprotkb:Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2(gene name synonym)|uniprotkb:Tanc2(gene name)|psi-mi:Tanc2(display_short)|uniprotkb:Kiaa1148(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000053580(gene)|ensembl:ENSMUST00000100330(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0030424"(axon)|go:"GO:0043197"(dendritic spine)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099519"(dense core granule cytoskeletal transport)|interpro:IPR002110(Ankyrin)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|mint:A2A690|refseq:NP_851416.2	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:pr3yhn1QUhZm0o9/xXGd9g+QFoo10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:A2CG49	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-770321|uniprotkb:A2CG50|uniprotkb:A2CG51|uniprotkb:A2CG52|uniprotkb:A2CG53|uniprotkb:Q3TYL1|uniprotkb:Q3UTA5|uniprotkb:Q8BTT9|uniprotkb:Q8C4Q2|uniprotkb:Q9CVA9|uniprotkb:Q3TXY8|uniprotkb:B2RXR5|uniprotkb:D3Z559|ensembl:ENSMUSP00000076088	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kalrn_mouse(display_long)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001157740.1|refseq:XP_006522445.1|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000719(Protein kinase, core)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018159|interpro:IPR028570|interpro:IPR035899|interpro:IPR036028|interpro:IPR036116|interpro:IPR036179|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSMUSG00000061751(gene)|ensembl:ENSMUST00000076810(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019899"(enzyme binding)|go:"GO:0035176"(social behavior)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042711"(maternal behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0046959"(habituation)|mint:A2CG49|rcsb pdb:1WFW|reactome:R-MMU-193648|reactome:R-MMU-3928662|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5687128|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013408|interpro:IPR036865	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:pDqdA2QNbqgLE3eYQXVVW2cxIyo10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CJ67	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-21991569|uniprotkb:Q8BSY8|uniprotkb:Q8CJ66|uniprotkb:Q8R175|uniprotkb:Q91Z19|uniprotkb:Q9D5N7|ensembl:ENSMUSP00000053190|ensembl:ENSMUSP00000124505	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:stau2_mouse(display_long)|uniprotkb:Stau2(gene name)|psi-mi:Stau2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001104742.1|refseq:NP_001333974.1|refseq:NP_079579.2|refseq:XP_006495591.1|refseq:XP_006495595.1|refseq:XP_011236689.1|refseq:XP_011236691.1|refseq:XP_017176591.1|ensembl:ENSMUSG00000025920(gene)|ensembl:ENSMUST00000054668(transcript)|ensembl:ENSMUST00000162751(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005874"(microtubule)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0019894"(kinesin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098964"(anterograde dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR044464|interpro:IPR044473|interpro:IPR044474|interpro:IPR044476|mint:Q8CJ67|rcsb pdb:1UHZ	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:94qldY96W9zvErbdJybhouGqEcY10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8BWS5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472832|ensembl:ENSMUSP00000051805|uniprotkb:Q69Z30	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:grin3_mouse(display_long)|uniprotkb:Gprin3(gene name)|psi-mi:Gprin3(display_short)|uniprotkb:Kiaa2027(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000045441(gene)|ensembl:ENSMUST00000051065(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0031175"(neuron projection development)|interpro:IPR026646|interpro:IPR032745|mint:Q8BWS5|refseq:NP_899006.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:TUt7HEqIihPNC+yWsH42oCCXRVQ10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3TLH4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6908845|ensembl:ENSMUSP00000138433|uniprotkb:E9QKG5|uniprotkb:Q05CS4|uniprotkb:Q05DM5|uniprotkb:Q3TKF3|uniprotkb:Q3UXU5|uniprotkb:Q4FZE4|uniprotkb:Q66K03|uniprotkb:Q6P3F4|uniprotkb:Q80TK3|uniprotkb:Q80YR0|uniprotkb:Q8BMJ4|uniprotkb:Q8C1K7|uniprotkb:Q8CGH3	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:prc2c_mouse(display_long)|uniprotkb:Prrc2c(gene name)|psi-mi:Prrc2c(display_short)|uniprotkb:Bat2d(gene name synonym)|uniprotkb:Bat2d1(gene name synonym)|uniprotkb:Bat2l2(gene name synonym)|uniprotkb:Kiaa1096(gene name synonym)|uniprotkb:BAT2 domain-containing protein 1(gene name synonym)|uniprotkb:HLA-B-associated transcript 2-like 2(gene name synonym)|uniprotkb:Proline-rich and coiled-coil-containing protein 2C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_011237086.1|ensembl:ENSMUSG00000040225(gene)|ensembl:ENSMUST00000182660(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0034063"(stress granule assembly)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:Q3TLH4|refseq:NP_001074759.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:lJHI4KKm0yJpyg2mURs2zCXOrSY10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q4U2R1	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11068779|uniprotkb:Q9Z171|uniprotkb:O88473|uniprotkb:Q80VV7|uniprotkb:Q3UFQ6|uniprotkb:Q9Z168|uniprotkb:Q3TST2|uniprotkb:Q3TRJ8|uniprotkb:Q7TPR5|uniprotkb:E9PZT6|uniprotkb:Q3TS47|uniprotkb:Q5DU32|uniprotkb:Q3URH7|uniprotkb:Q9QYT1|ensembl:ENSMUSP00000075579|ensembl:ENSMUSP00000131573	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:herc2_mouse(display_long)|uniprotkb:Herc2(gene name)|psi-mi:Herc2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:Jdf2(gene name synonym)|uniprotkb:Kiaa0393(gene name synonym)|uniprotkb:Rjs(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_034548.2|refseq:XP_006540700.1|refseq:XP_006540701.1|refseq:XP_006540702.1|ensembl:ENSMUSG00000030451(gene)|ensembl:ENSMUST00000076226(transcript)|ensembl:ENSMUST00000164095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:Q4U2R1|reactome:R-MMU-3108214|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|reactome:R-MMU-983168	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:yBOZ4XbUYep0KPiinjS9LQH52D810090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9JL04	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16095034|ensembl:ENSMUSP00000030039|uniprotkb:Q505D3	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:fmn2_mouse(display_long)|uniprotkb:Fmn2(gene name)|psi-mi:Fmn2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000028354(gene)|ensembl:ENSMUST00000030039(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005938"(cell cortex)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016344"(meiotic chromosome movement towards spindle pole)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0040038"(polar body extrusion after meiotic divisions)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045010"(actin nucleation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051758"(homologous chromosome movement towards spindle pole in meiosis I anaphase)|go:"GO:0070649"(formin-nucleated actin cable assembly)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:2000781"(positive regulation of double-strand break repair)|interpro:IPR001265(Formin)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR042201|mint:Q9JL04|go:"GO:0051295"(establishment of meiotic spindle localization)|refseq:NP_062318.2|dip:DIP-60685N	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:VHOaI1FPm/kBn74SvSQNxAnHv4A10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q2PFD7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26473367|uniprotkb:Q3TTA1|uniprotkb:Q80TN6|uniprotkb:Q80UZ7|uniprotkb:Q8CEA6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:psd3_mouse(display_long)|uniprotkb:Psd3(gene name)|psi-mi:Psd3(display_short)|uniprotkb:Efa6d(gene name synonym)|uniprotkb:Kiaa0942(gene name synonym)|uniprotkb:Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 D(gene name synonym)|uniprotkb:Pleckstrin homology and SEC7 domain-containing protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0032587"(ruffle membrane)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0032011"(ARF protein signal transduction)|mint:Q2PFD7|refseq:NP_081902.1|refseq:NP_084539.2|refseq:NP_808366.2|refseq:XP_017168191.1|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR041681|interpro:IPR001849(Pleckstrin-like)|interpro:IPR023394|interpro:IPR000904(SEC7-like)|interpro:IPR035999	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Ay5ZY8c2m+sjt3Qu5Qoht8KEGjs10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q62141	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-591450|uniprotkb:O54976|uniprotkb:Q6A013|uniprotkb:Q8VCB8|uniprotkb:Q8VDZ5|ensembl:ENSMUSP00000004494	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:sin3b_mouse(display_long)|uniprotkb:Transcriptional corepressor Sin3b(gene name synonym)|uniprotkb:Histone deacetylase complex subunit Sin3b(gene name synonym)|uniprotkb:Sin3b(gene name)|psi-mi:Sin3b(display_short)|uniprotkb:Kiaa0700(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001106719.1|refseq:NP_033214.2|dip:DIP-470N|ensembl:ENSMUSG00000031622(gene)|ensembl:ENSMUST00000004494(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000805"(X chromosome)|go:"GO:0000806"(Y chromosome)|go:"GO:0001741"(XY body)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0016580"(Sin3 complex)|go:"GO:0030849"(autosome)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048738"(cardiac muscle tissue development)|interpro:IPR003822(Paired amphipathic helix)|interpro:IPR013194(Histone deacetylase interacting)|interpro:IPR031693|interpro:IPR036600|interpro:IPR039774|mint:Q62141|rcsb pdb:1E91|rcsb pdb:1PD7|rcsb pdb:2CR7|rcsb pdb:2CZY|rcsb pdb:2F05|rcsb pdb:5Y95|reactome:R-MMU-400206|reactome:R-MMU-8936459|reactome:R-MMU-9707564|go:"GO:0016575"(histone deacetylation)	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:RILCV7LIlLhVsSBz43m63WcJ0B810090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6PGL7	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-5298041|uniprotkb:Q3TQ99|uniprotkb:Q80TW8|uniprotkb:Q80UQ4|uniprotkb:Q8CAP0|ensembl:ENSMUSP00000038983	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:wasc2_mouse(display_long)|uniprotkb:Washc2(gene name)|psi-mi:Washc2(display_short)|uniprotkb:D6Wsu116e(gene name synonym)|uniprotkb:Fam21(gene name synonym)|uniprotkb:Kiaa0592(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080861.2|ensembl:ENSMUSG00000024104(gene)|ensembl:ENSMUST00000036759(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0015031"(protein transport)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071203"(WASH complex)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1905394"(retromer complex binding)|interpro:IPR029341|mint:Q6PGL7	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ZahcV9CREm4afcw7WRGKN5S9w8c10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6PNC0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26473346|ensembl:ENSMUSP00000137871|uniprotkb:Q3TLG8|uniprotkb:Q6PHM6|uniprotkb:Q8BQF2	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dmxl1_mouse(display_long)|uniprotkb:Dmxl1(gene name)|psi-mi:Dmxl1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000037416(gene)|ensembl:ENSMUST00000180611(transcript)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0043291"(RAVE complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR022033|interpro:IPR036322|mint:Q6PNC0|refseq:NP_001074840.2	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:0qXj+GIDF1euCfht9SE/7CzIjZs10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O88520	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2552311|ensembl:ENSMUSP00000025932|ensembl:ENSMUSP00000127932|uniprotkb:Q8BVL0|uniprotkb:Q91VH8|uniprotkb:Q3UJH6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:shoc2_mouse(display_long)|uniprotkb:Shoc2(gene name)|psi-mi:Shoc2(display_short)|uniprotkb:Protein soc-2 homolog(gene name synonym)|uniprotkb:Protein sur-8 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_011245601.1|ensembl:ENSMUST00000169861(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027036|interpro:IPR032675|mint:O88520|reactome:R-MMU-5673000|ensembl:ENSMUST00000025932(transcript)|refseq:NP_001161977.1|refseq:NP_062632.2|ensembl:ENSMUSG00000024976(gene)|refseq:XP_017173749.1|refseq:XP_006527291.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:13L09X2HzmpTeJz7rnIC0y3aXc810090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q99JR8	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-5736813|uniprotkb:B1ARI7|uniprotkb:B1ARJ6|ensembl:ENSMUSP00000021052	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:smrd2_mouse(display_long)|uniprotkb:Smarcd2(gene name)|psi-mi:Smarcd2(display_short)|uniprotkb:Baf60b(gene name synonym)|uniprotkb:60 kDa BRG-1/Brm-associated factor subunit B(gene name synonym)|uniprotkb:BRG1-associated factor 60B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001123659.1|dip:DIP-58950N|ensembl:ENSMUSG00000078619(gene)|ensembl:ENSMUST00000021052(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0043044"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR019835|interpro:IPR030090|interpro:IPR036885|mint:Q99JR8|reactome:R-MMU-3214858|reactome:R-MMU-8939243	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:5tl1MAFYUH72fxGvBkEarWWr4o410090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8K2Y9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-21986270|uniprotkb:Q5SUA3|ensembl:ENSMUSP00000000388	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ccm2_mouse(display_long)|uniprotkb:Ccm2(gene name)|psi-mi:Ccm2(display_short)|uniprotkb:Osm(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:Osmosensing scaffold for MEKK3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_666126.1|ensembl:ENSMUSG00000000378(gene)|ensembl:ENSMUST00000000388(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0001944"(vasculature development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007507"(heart development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|mint:Q8K2Y9	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:vx4CiPCssN2jKSdj2y0tbtWFA1w10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q64511	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2325586|uniprotkb:Q7TQG4|ensembl:ENSMUSP00000017629	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:top2b_mouse(display_long)|uniprotkb:Top2b(gene name)|psi-mi:Top2b(display_short)|uniprotkb:DNA topoisomerase II, beta isozyme(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_033435.2|ensembl:ENSMUSG00000017485(gene)|ensembl:ENSMUST00000017629(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0001764"(neuron migration)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003916"(DNA topoisomerase activity)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006265"(DNA topological change)|go:"GO:0007409"(axonogenesis)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045870"(positive regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR012542(DTHCT)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013757(DNA topoisomerase, type IIA, subunit A, alpha-helical)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|interpro:IPR020568|interpro:IPR028467|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|mint:Q64511|reactome:R-MMU-4615885	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:dB5M5wdu6YqBC7uBMe34toA5ISQ10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q05D44	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471954|ensembl:ENSMUSP00000027252|uniprotkb:Q3SYI4|uniprotkb:Q3TQJ8|uniprotkb:Q3UL37|uniprotkb:Q3UM39|uniprotkb:Q6PAI0|uniprotkb:Q8CFF4|uniprotkb:Q8CGD6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:if2p_mouse(display_long)|uniprotkb:Eif5b(gene name)|psi-mi:Eif5b(display_short)|uniprotkb:If2(gene name synonym)|uniprotkb:Translation initiation factor IF-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000026083(gene)|ensembl:ENSMUST00000027252(transcript)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0046872"(metal ion binding)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR015760(Translation initiation factor 2 related)|interpro:IPR023115|interpro:IPR027417|interpro:IPR036925|mint:Q05D44|reactome:R-MMU-72706|refseq:NP_938045.2	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:I/f4dge9EuoZmhRTG/BxM27HaHM10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P70451	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26473242|ensembl:ENSMUSP00000000129|uniprotkb:Q61561|uniprotkb:Q6PEE5|uniprotkb:Q80UI3|uniprotkb:Q8C481|uniprotkb:Q9EQ77	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:fer_mouse(display_long)|uniprotkb:Fer(gene name)|psi-mi:Fer(display_short)|uniprotkb:Fert2(gene name synonym)|uniprotkb:Proto-oncogene c-Fer(gene name synonym)|uniprotkb:p94-Fer(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033007"(negative regulation of mast cell activation involved in immune response)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0036119"(response to platelet-derived growth factor)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038109"(Kit signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045087"(innate immune response)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050904"(diapedesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR028539|interpro:IPR031160|interpro:IPR035849|interpro:IPR037452|mint:P70451|reactome:R-MMU-1433557|interpro:IPR036860|ensembl:ENSMUSG00000000127(gene)|ensembl:ENSMUST00000000129(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000785"(chromatin)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006935"(chemotaxis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_001033086.2|refseq:NP_001273344.1|refseq:NP_032026.2|refseq:XP_006523703.1|refseq:XP_006523704.1|refseq:XP_006523706.1|refseq:XP_011244595.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:7QxEVrbvKqJr1rdLriakyOiv5k810090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P63158	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6665811|ensembl:ENSMUSP00000082682|ensembl:ENSMUSP00000106131|ensembl:ENSMUSP00000106132|uniprotkb:P07155|uniprotkb:P27109|uniprotkb:P27428	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:hmgb1_mouse(display_long)|uniprotkb:Hmgb1(gene name)|psi-mi:Hmgb1(display_short)|uniprotkb:Hmg-1(gene name synonym)|uniprotkb:Hmg1(gene name synonym)|uniprotkb:High mobility group protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001300823.1|ensembl:ENSMUSG00000066551(gene)|ensembl:ENSMUST00000085546(transcript)|ensembl:ENSMUST00000093196(transcript)|ensembl:ENSMUST00000110505(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000401"(open form four-way junction DNA binding)|go:"GO:0000402"(crossed form four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001654"(eye development)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002270"(plasmacytoid dendritic cell activation)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002643"(regulation of tolerance induction)|go:"GO:0002840"(regulation of T cell mediated immune response to tumor cell)|go:"GO:0003681"(bent DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006284"(base-excision repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008201"(heparin binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009986"(cell surface)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010858"(calcium-dependent protein kinase regulator activity)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016829"(lyase activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0017055"(negative regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032072"(regulation of restriction endodeoxyribonuclease activity)|go:"GO:0032392"(DNA geometric change)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0005576"(extracellular region)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000426"(negative regulation of apoptotic cell clearance)|go:"GO:2000819"(regulation of nucleotide-excision repair)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|interpro:IPR031076|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|interpro:IPR036910|mint:P63158|rcsb pdb:5ZDZ|rcsb pdb:5ZE0|rcsb pdb:5ZE1|rcsb pdb:5ZE2|reactome:R-MMU-140342|reactome:R-MMU-445989|reactome:R-MMU-5620971|reactome:R-MMU-5686938|reactome:R-MMU-6798695|reactome:R-MMU-933542|reactome:R-MMU-879415|refseq:NP_034569.1|refseq:XP_003945388.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Ujrs2BBefbmNxZj+S9H8lhWjnNc10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P26040	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-645505|uniprotkb:Q80ZT8|uniprotkb:Q9DCI1|ensembl:ENSMUSP00000063734	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ezri_mouse(display_long)|uniprotkb:Vil2(gene name synonym)|uniprotkb:p81(gene name synonym)|uniprotkb:Cytovillin(gene name synonym)|uniprotkb:Villin-2(gene name synonym)|uniprotkb:Ezr(gene name)|psi-mi:Ezr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_033536.2|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044297"(cell body)|go:"GO:0044393"(microspike)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097454"(Schwann cell microvillus)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902896"(terminal web assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|interpro:IPR008954(Moesin)|mint:P26040|reactome:R-MMU-373752|reactome:R-MMU-437239|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|ensembl:ENSMUSG00000052397(gene)|ensembl:ENSMUST00000064234(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0001931"(uropod)|go:"GO:0001951"(intestinal D-glucose absorption)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:PspmkV3JA32h1VGLkUgha3a59AA10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q61550	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2550110|uniprotkb:Q3TQ09|uniprotkb:Q810A8|ensembl:ENSMUSP00000022927|uniprotkb:P70219|uniprotkb:Q91VB9|uniprotkb:Q9DBU4	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rad21_mouse(display_long)|uniprotkb:Rad21(gene name)|psi-mi:Rad21(display_short)|uniprotkb:Hr21(gene name synonym)|uniprotkb:Pokeweed agglutinin-binding protein 29(gene name synonym)|uniprotkb:SCC1 homolog(gene name synonym)|uniprotkb:Scc1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0008278"(cohesin complex)|go:"GO:0010972"(negative regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016363"(nuclear matrix)|go:"GO:0034990"(nuclear mitotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0045841"(negative regulation of mitotic metaphase/anaphase transition)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|interpro:IPR006909(Rad21/Rec8 like protein, C-terminal)|interpro:IPR006910(Rad21/Rec8 like protein, N-terminal)|interpro:IPR023093|interpro:IPR036390|interpro:IPR039781|mint:Q61550|reactome:R-MMU-2467813|reactome:R-MMU-2468052|go:"GO:0003682"(chromatin binding)|reactome:R-MMU-2470946|reactome:R-MMU-2500257|reactome:R-MMU-3108214|ensembl:ENSMUSG00000022314(gene)|ensembl:ENSMUST00000022927(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000795"(synaptonemal complex)|refseq:NP_033035.3|refseq:XP_006520707.1|refseq:XP_006520708.1|dip:DIP-56655N	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:TXbWgmegqmBbcsQxxC4t7A/nc3o10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P26043	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-647737|uniprotkb:Q3TS85|uniprotkb:Q9QW27|ensembl:ENSMUSP00000000590|ensembl:ENSMUSP00000128249	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:radi_mouse(display_long)|uniprotkb:ESP10(gene name synonym)|uniprotkb:Rdx(gene name)|psi-mi:Rdx(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001098086.1|refseq:NP_033067.2|dip:DIP-29091N|ensembl:ENSMUSG00000032050(gene)|ensembl:ENSMUST00000000590(transcript)|ensembl:ENSMUST00000163153(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032231"(regulation of actin filament bundle assembly)|go:"GO:0032420"(stereocilium)|go:"GO:0034111"(negative regulation of homotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0045176"(apical protein localization)|go:"GO:0045177"(apical part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903392"(negative regulation of adherens junction organization)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P26043|rcsb pdb:1GC6|rcsb pdb:1GC7|rcsb pdb:1J19|rcsb pdb:2D10|rcsb pdb:2D11|rcsb pdb:2D2Q|rcsb pdb:2EMS|rcsb pdb:2EMT|rcsb pdb:2YVC|rcsb pdb:2ZPY|rcsb pdb:3X23|reactome:R-MMU-437239	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:d7wqsdTau9b92O3q6LW+/pyKL1w10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q505F5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2255533|uniprotkb:Q3U380|uniprotkb:Q6ZPW2|uniprotkb:Q9CUZ0|ensembl:ENSMUSP00000030894	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:lrc47_mouse(display_long)|uniprotkb:Kiaa1185(gene name synonym)|uniprotkb:Lrrc47(gene name)|psi-mi:Lrrc47(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_957678.1|ensembl:ENSMUSG00000029028(gene)|ensembl:ENSMUST00000030894(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005146(B3/B4 tRNA-binding domain)|interpro:IPR020825|interpro:IPR032675|mint:Q505F5	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:rPKKMiAYd+Dtcvc0CJAMiCDhF/E10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8VE70	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-21986299|uniprotkb:Q9DAR3|uniprotkb:Q9WV43|ensembl:ENSMUSP00000125752	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:pdc10_mouse(display_long)|uniprotkb:Pdcd10(gene name)|psi-mi:Pdcd10(display_short)|uniprotkb:Tfar15(gene name synonym)|uniprotkb:TF-1 cell apoptosis-related protein 15(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_062719.2|ensembl:ENSMUSG00000027835(gene)|ensembl:ENSMUST00000161137(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009652(Protein of unknown function DUF1241)|mint:Q8VE70	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:IdjBfq5g9A8mofu74PwfzlwzWx010090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q69ZH9	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472113|uniprotkb:Q8BNY7|uniprotkb:Q9JJD6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rhg23_mouse(display_long)|uniprotkb:Arhgap23(gene name)|psi-mi:Arhgap23(display_short)|uniprotkb:Kiaa1501(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 23(gene name synonym)|uniprotkb:MNCb-1301(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0005096"(GTPase activator activity)|go:"GO:0007165"(signal transduction)|reactome:R-MMU-8980692|reactome:R-MMU-9013149|mint:Q69ZH9|refseq:NP_067468.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR041489|interpro:IPR036034|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR041681|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR000198(RhoGAP)	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:KTCeDuLV+qHtInBwC3PzUFi0VO810090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q61290	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-770918	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cac1e_mouse(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.3(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 6(gene name synonym)|uniprotkb:Brain calcium channel II(gene name synonym)|uniprotkb:Cacna1e(gene name)|psi-mi:Cacna1e(display_short)|uniprotkb:Cach6(gene name synonym)|uniprotkb:Cacnl1a6(gene name synonym)|uniprotkb:Cchra1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR005449(Voltage-dependent calcium channel, R-type, alpha-1 subunit)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR027359|interpro:IPR031649|go:"GO:0001662"(behavioral fear response)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0042596"(fear response)|go:"GO:0043204"(perikaryon)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048265"(response to pain)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0050877"(nervous system process)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0090273"(regulation of somatostatin secretion)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|reactome:R-MMU-112308|reactome:R-MMU-422356|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042593"(glucose homeostasis)|mint:Q61290	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:EaL/xQzdjloSLb88yMW1gqddCjM10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O54774	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-775247|ensembl:ENSMUSP00000020420	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ap3d1_mouse(display_long)|uniprotkb:AP-3 complex subunit delta(gene name synonym)|uniprotkb:Delta-adaptin(gene name synonym)|uniprotkb:Ap3d1(gene name)|psi-mi:Ap3d1(display_short)|uniprotkb:Ap3d(gene name synonym)|uniprotkb:Adaptor-related protein complex 3 subunit delta-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_031486.1|dip:DIP-32163N|ensembl:ENSMUSG00000020198(gene)|ensembl:ENSMUST00000020420(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030424"(axon)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043195"(terminal bouton)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048499"(synaptic vesicle membrane organization)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098943"(neurotransmitter receptor transport, postsynaptic endosome to lysosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR010474(Bovine leukaemia virus receptor)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017105(Adaptor protein complex AP-3, delta subunit)|mint:O54774	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:q83u6ORB4zYNuQihE4PI1rhvSkY10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P70398	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2214043|uniprotkb:E9QLY0|uniprotkb:Q62497	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:usp9x_mouse(display_long)|uniprotkb:Ubiquitin thioesterase FAF-X(gene name synonym)|uniprotkb:Usp9x(gene name)|psi-mi:Usp9x(display_short)|uniprotkb:Fafl(gene name synonym)|uniprotkb:Fam(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease FAF-X(gene name synonym)|uniprotkb:Deubiquitinating enzyme FAF-X(gene name synonym)|uniprotkb:Fat facets protein-related, X-linked(gene name synonym)|uniprotkb:Ubiquitin-specific protease 9, X chromosome(gene name synonym)|uniprotkb:Ubiquitin carboxyl-terminal hydrolase FAM(gene name synonym)|uniprotkb:Fat facets homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR016024(Armadillo-type fold)|interpro:IPR028889|refseq:NP_033507.2|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:P70398|interpro:IPR038765|interpro:IPR021905|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021698"(cerebellar cortex structural organization)|go:"GO:0021766"(hippocampus development)|go:"GO:0030426"(growth cone)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045177"(apical part of cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|reactome:R-MMU-2173795|reactome:R-MMU-5689880|reactome:R-MMU-8866652|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-9033241	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:QXx5gkd+PxoNgIj2b2dLjpCuNr410090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:A2AF47	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16733818|ensembl:ENSMUSP00000033419|uniprotkb:Q5KTP7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:doc11_mouse(display_long)|uniprotkb:Activated Cdc42-associated guanine nucleotide exchange factor(gene name synonym)|uniprotkb:Zizimin-2(gene name synonym)|uniprotkb:Dock11(gene name)|psi-mi:Dock11(display_short)|uniprotkb:Ziz2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000031093(gene)|ensembl:ENSMUST00000033419(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021816|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR035892|interpro:IPR037809|interpro:IPR043161|interpro:IPR043162|mint:A2AF47|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-983231|refseq:NP_001009947.2	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Hj/RFYqY5pvpk7vrJ1VKTZ0K0e010090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3UH60	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16724475|ensembl:ENSMUSP00000097777|uniprotkb:Q8C1W5|uniprotkb:Q8CDG9|uniprotkb:Q8CHA2	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dip2b_mouse(display_long)|uniprotkb:Dip2b(gene name)|psi-mi:Dip2b(display_short)|uniprotkb:Kiaa1463(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000023026(gene)|ensembl:ENSMUST00000100203(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR010506(DMAP1-binding)|interpro:IPR037337|interpro:IPR042099|mint:Q3UH60|refseq:NP_001152833.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:fgjJT8HpeVRm1osKj8p2Dx7WxU810090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q3LAC4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26471859|ensembl:ENSMUSP00000027056|uniprotkb:E9QMG3|uniprotkb:Q3UQI2|uniprotkb:Q3UU18|uniprotkb:Q9CXD5	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:prex2_mouse(display_long)|uniprotkb:Prex2(gene name)|psi-mi:Prex2(display_short)|uniprotkb:Depdc2(gene name synonym)|uniprotkb:DEP domain-containing protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000048960(gene)|ensembl:ENSMUST00000027056(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0048813"(dendrite morphogenesis)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR037367|mint:Q3LAC4|reactome:R-MMU-8948751|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|refseq:NP_083801.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:WFnLEKIfvbYlUiklWxhr1Mw11ZA10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8K2D3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16369796|ensembl:ENSMUSP00000049146|uniprotkb:Q3THV7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:edc3_mouse(display_long)|uniprotkb:YjeF domain-containing protein 1(gene name synonym)|uniprotkb:Edc3(gene name)|psi-mi:Edc3(display_short)|uniprotkb:Yjdc(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:1990174"(phosphodiesterase decapping endonuclease activity)|interpro:IPR004443(YjeF-related protein, N-terminal)|interpro:IPR019050|interpro:IPR025609|interpro:IPR025762|interpro:IPR034107|interpro:IPR036652|mint:Q8K2D3|reactome:R-MMU-430039|ensembl:ENSMUSG00000038957(gene)|ensembl:ENSMUST00000043990(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|refseq:NP_722494.1|refseq:XP_011241062.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:gxI+R4pKdhtjglIi5z4PNMDktbk10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P27659	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2526690|uniprotkb:O89071|uniprotkb:Q91VJ6|ensembl:ENSMUSP00000080354	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl3_mouse(display_long)|uniprotkb:Rpl3(gene name)|psi-mi:Rpl3(display_short)|uniprotkb:J1 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_038790.2|ensembl:ENSMUSG00000060036(gene)|ensembl:ENSMUST00000081650(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045202"(synapse)|go:"GO:0071353"(cellular response to interleukin-4)|interpro:IPR000597(Ribosomal protein L3)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR019926|mint:P27659|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:GrC8OWBLXBaBuOrzEOvyR6cid1A10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:B1AY10	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-11707102|uniprotkb:Q3U2A7|uniprotkb:Q3UK95|uniprotkb:Q3UMW1|uniprotkb:Q7TPT4|uniprotkb:Q8CC59|uniprotkb:Q9DBC8|uniprotkb:Q9JKW7|ensembl:ENSMUSP00000095747	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:nfx1_mouse(display_long)|uniprotkb:Nfx1(gene name)|psi-mi:Nfx1(display_short)|uniprotkb:Nuclear transcription factor, X box-binding protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001277377.1|refseq:NP_001277378.1|refseq:NP_076228.2|ensembl:ENSMUSG00000028423(gene)|ensembl:ENSMUST00000098143(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000967(Zinc finger, NF-X1-type)|interpro:IPR001374(Single-stranded nucleic acid binding R3H)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR019787|interpro:IPR034076|interpro:IPR034078|interpro:IPR036867|mint:B1AY10|go:"GO:0005730"(nucleolus)	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:fFzQDjd9a1arVzJAhXzDcvmhE7c10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q91YD3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6097113|ensembl:ENSMUSP00000022535|ensembl:ENSMUSP00000152897|uniprotkb:Q6NZE3	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dcp1a_mouse(display_long)|uniprotkb:Dcp1a(gene name)|psi-mi:Dcp1a(display_short)|uniprotkb:Mitc1(gene name synonym)|uniprotkb:Smif(gene name synonym)|uniprotkb:MAD homolog 4-interacting transcription coactivator 1(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:Transcription factor SMIF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q91YD3|reactome:R-MMU-430039|reactome:R-MMU-450385|reactome:R-MMU-450513|reactome:R-MMU-975957|ensembl:ENSMUSG00000021962(gene)|ensembl:ENSMUST00000022535(transcript)|ensembl:ENSMUST00000225196(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_598522.3	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:GNFxv657QCnGA5H6YA6nxBPFGpE10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P33173	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2013334|uniprotkb:Q61770	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kif1a_mouse(display_long)|uniprotkb:Kif1a(gene name)|psi-mi:Kif1a(display_short)|uniprotkb:Atsv(gene name synonym)|uniprotkb:Kif1(gene name synonym)|uniprotkb:Axonal transporter of synaptic vesicles(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	mint:P33173|dip:DIP-46956N|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0098674"(extrinsic component of neuronal dense core vesicle membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:0099519"(dense core granule cytoskeletal transport)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990048"(anterograde neuronal dense core vesicle transport)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019821|interpro:IPR022140|interpro:IPR022164|interpro:IPR027417|interpro:IPR027640|interpro:IPR032405|interpro:IPR036961|rcsb pdb:1I5S|rcsb pdb:1I6I|rcsb pdb:1IA0|rcsb pdb:1VFV|rcsb pdb:1VFW|rcsb pdb:1VFX|rcsb pdb:1VFZ|rcsb pdb:2HXF|rcsb pdb:2HXH|rcsb pdb:2ZFI|rcsb pdb:2ZFJ|rcsb pdb:2ZFK|rcsb pdb:2ZFL|rcsb pdb:2ZFM|reactome:R-MMU-2132295|reactome:R-MMU-6811434|reactome:R-MMU-983189	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:TPA+Boj3ol4jv+aZcFpgA4eEblA10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P62843	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2526764|uniprotkb:P11174|uniprotkb:Q52KC9|ensembl:ENSMUSP00000069004	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rs15_mouse(display_long)|uniprotkb:Rps15(gene name)|psi-mi:Rps15(display_short)|uniprotkb:Rig(gene name synonym)|uniprotkb:RIG protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000063457(gene)|ensembl:ENSMUST00000068408(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0045202"(synapse)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097421"(liver regeneration)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|interpro:IPR002222(Ribosomal protein S19/S15)|interpro:IPR005713(Ribosomal protein S15, eukaryotic/archaeal)|interpro:IPR020934|interpro:IPR023575|mint:P62843|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|refseq:NP_033117.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:lJJOew1txuTwFlhKu4Z+AkPS5H010090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:E9Q6P5	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472026|ensembl:ENSMUSP00000052107	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ttc7b_mouse(display_long)|uniprotkb:Ttc7b(gene name)|psi-mi:Ttc7b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000033530(gene)|ensembl:ENSMUST00000062957(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|mint:E9Q6P5|refseq:NP_001028385.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ZPk8i1GIUVQ38oFmzSf936xq0lE10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8BHL3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26472950|ensembl:ENSMUSP00000113307|uniprotkb:Q6GQW9|uniprotkb:Q6PIZ5|uniprotkb:Q91XR3	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:tb10b_mouse(display_long)|uniprotkb:Tbc1d10b(gene name)|psi-mi:Tbc1d10b(display_short)|uniprotkb:Protein wz3-85(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000042492(gene)|ensembl:ENSMUST00000120705(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR035969|mint:Q8BHL3|reactome:R-MMU-8854214|refseq:NP_653105.3	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:2H3lfaMqWZeTEq6xjmrOJus3XnA10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P47962	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-773940|uniprotkb:Q9CR19|ensembl:ENSMUSP00000080854	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rl5_mouse(display_long)|uniprotkb:Rpl5(gene name)|psi-mi:Rpl5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_058676.1|ensembl:ENSMUSG00000058558(gene)|ensembl:ENSMUST00000082223(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1905017"(positive regulation of isoleucine-tRNA ligase activity)|go:"GO:1905020"(positive regulation of methionine-tRNA ligase activity)|go:"GO:1905023"(positive regulation of threonine-tRNA ligase activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR005485(Ribosomal protein L5, eukaryotic)|interpro:IPR025607|mint:P47962|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:29DmVSczDJV/5gL/nPYYBBEdo9o10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8K310	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-1216295|ensembl:ENSMUSP00000125761|ensembl:ENSMUSP00000158074|ensembl:ENSMUSP00000158537	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:matr3_mouse(display_long)|uniprotkb:Matr3(gene name)|psi-mi:Matr3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_034901.2|rcsb pdb:1X4F|rcsb pdb:1X4D|ensembl:ENSMUSG00000037236(gene)|ensembl:ENSMUST00000166793(transcript)|ensembl:ENSMUST00000235199(transcript)|ensembl:ENSMUST00000237744(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034928|interpro:IPR034930|interpro:IPR035979|mint:Q8K310	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:AwtFbI+oRfha+mn/v3yzG6bNXYg10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q7TSH2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-911437|ensembl:ENSMUSP00000050788	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kpbb_mouse(display_long)|uniprotkb:Phkb(gene name)|psi-mi:Phkb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_955517.1|ensembl:ENSMUSG00000036879(gene)|ensembl:ENSMUST00000053771(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|interpro:IPR008734(Phosphorylase kinase alphabeta)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR011613(Glycoside hydrolase 15-related)|mint:Q7TSH2|reactome:R-MMU-70221|refseq:XP_006530595.1|refseq:XP_006530596.1|refseq:XP_006530597.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:qRovReuecws5KcJl6XVcnVO5FW410090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O70133	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2657677|uniprotkb:O35931|uniprotkb:O54703|uniprotkb:Q5FWY1|uniprotkb:Q6R5F7|uniprotkb:Q9CSA2	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:dhx9_mouse(display_long)|uniprotkb:Dhx9(gene name)|psi-mi:Dhx9(display_short)|uniprotkb:Ddx9(gene name synonym)|uniprotkb:Nuclear DNA helicase II(gene name synonym)|uniprotkb:DEAH box protein 9(gene name synonym)|uniprotkb:RNA helicase A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_031868.2|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR007502(Helicase-associated region)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001069"(regulatory region RNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005844"(polysome)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007623"(circadian rhythm)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016442"(RISC complex)|go:"GO:0016604"(nuclear body)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033679"(3'-5' DNA/RNA helicase activity)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045142"(triplex DNA binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0047429"(nucleoside-triphosphate diphosphatase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070269"(pyroptosis)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904973"(positive regulation of viral translation)|go:"GO:1905172"(RISC complex binding)|go:"GO:1905538"(polysome binding)|go:"GO:1905698"(positive regulation of polysome binding)|go:"GO:1990518"(single-stranded 3'-5' DNA helicase activity)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000765"(regulation of cytoplasmic translation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|rcsb pdb:1UIL|rcsb pdb:1WHQ|rcsb pdb:2RS6|rcsb pdb:2RS7|reactome:R-MMU-1810476|reactome:R-MMU-3134963|reactome:R-MMU-72163|interpro:IPR027417|mint:O70133|interpro:IPR044445|interpro:IPR044446|interpro:IPR044447	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:8NHxvbw0StglewhGm3e7Pi/8oOg10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O88532	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-645485|uniprotkb:Q3TY30|uniprotkb:Q8BS85|uniprotkb:Q8CGG5|uniprotkb:Q91VZ0|uniprotkb:Q9CT34|ensembl:ENSMUSP00000118911	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:zfr_mouse(display_long)|uniprotkb:Zfr(gene name)|psi-mi:Zfr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_035897.2|ensembl:ENSMUSG00000022201(gene)|ensembl:ENSMUST00000122941(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR006561(DZF)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043519|mint:O88532	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:ncNwFUEUk0r2XotuXm/9Tt4iB5w10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q80UM3	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2554211|uniprotkb:Q9JID5|uniprotkb:Q811Z9	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:naa15_mouse(display_long)|uniprotkb:Narg1(gene name synonym)|uniprotkb:NMDA receptor-regulated protein 1(gene name synonym)|uniprotkb:Naa15(gene name)|psi-mi:Naa15(display_short)|uniprotkb:Nat1(gene name synonym)|uniprotkb:Tbdn-1(gene name synonym)|uniprotkb:Tubedown(gene name synonym)|uniprotkb:N-terminal acetyltransferase 1(gene name synonym)|uniprotkb:Protein tubedown-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	interpro:IPR021183|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|go:"GO:0001525"(angiogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017196"(N-terminal peptidyl-methionine acetylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031415"(NatA complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0006474"(N-terminal protein amino acid acetylation)|mint:Q80UM3	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:hE4GwKw45rlC8XVDGmigsauWJMU10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8CC12	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470848|ensembl:ENSMUSP00000106329|uniprotkb:A2AW10|uniprotkb:Q149P8|uniprotkb:Q3U032	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:cdan1_mouse(display_long)|uniprotkb:Cdan1(gene name)|psi-mi:Cdan1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000027284(gene)|ensembl:ENSMUST00000110701(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0008104"(protein localization)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031497"(chromatin assembly)|interpro:IPR028171|interpro:IPR040031|mint:Q8CC12|refseq:NP_081167.2	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:5Nyg/Fnh9WKYy3DFp/o8OTH4LGA10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P18826	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470825|ensembl:ENSMUSP00000061991|uniprotkb:A2AI90	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kpb1_mouse(display_long)|uniprotkb:Phka1(gene name)|psi-mi:Phka1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000034055(gene)|ensembl:ENSMUST00000052012(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005964"(phosphorylase kinase complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR008734(Phosphorylase kinase alphabeta)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR011613(Glycoside hydrolase 15-related)|interpro:IPR012341(Six-hairpin glycosidase)|mint:P18826|reactome:R-MMU-70221|refseq:NP_032858.2	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:m6KkLpQv72gScTWLDJ2f1g4mtuo10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q08460	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9Z1X4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6260790|ensembl:ENSMUSP00000065770|uniprotkb:Q8BP80|uniprotkb:Q8K588|uniprotkb:Q8C2H8|uniprotkb:Q812A1|uniprotkb:Q80VD5	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ilf3_mouse(display_long)|uniprotkb:Ilf3(gene name)|psi-mi:Ilf3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001264250.1|ensembl:ENSMUSG00000032178(gene)|ensembl:ENSMUST00000067646(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006479"(protein methylation)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR033099|interpro:IPR043519|mint:Q9Z1X4|rcsb pdb:4AT7|rcsb pdb:4AT8|rcsb pdb:4AT9|rcsb pdb:4ATB|rcsb pdb:5DV7|refseq:XP_006510094.1|refseq:NP_001036172.1|refseq:NP_001036173.1|refseq:NP_034691.2|refseq:NP_001264251.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:vxZan3L6NAseX1Ib9Z7MQ82CM3E10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P56942	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26450331|ensembl:ENSMUSP00000044352|uniprotkb:Q9D220	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:mch_mouse(display_long)|uniprotkb:Pmch(gene name)|psi-mi:Pmch(display_short)|uniprotkb:Mch(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUST00000048621(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007631"(feeding behavior)|go:"GO:0009409"(response to cold)|go:"GO:0030354"(melanin-concentrating hormone activity)|go:"GO:0031777"(type 1 melanin-concentrating hormone receptor binding)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042756"(drinking behavior)|go:"GO:0045202"(synapse)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046005"(positive regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|interpro:IPR005456(Pre-pro melanin-concentrating hormone)|mint:P56942|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUSG00000035383(gene)|refseq:NP_084247.1	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:l3UbZeUaSJTBhc0jao6eg+D8Q4U10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9CXY6	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-2312782|uniprotkb:Q3U083|uniprotkb:Q5RKG0|uniprotkb:Q8CCY9|uniprotkb:Q99KS3|ensembl:ENSMUSP00000001042	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:ilf2_mouse(display_long)|uniprotkb:Ilf2(gene name)|psi-mi:Ilf2(display_short)|uniprotkb:Nf45(gene name synonym)|uniprotkb:Nuclear factor of activated T-cells 45 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_080650.1|ensembl:ENSMUSG00000001016(gene)|ensembl:ENSMUST00000001042(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR043519|mint:Q9CXY6|rcsb pdb:4AT7|rcsb pdb:4AT8|rcsb pdb:4AT9|rcsb pdb:4ATB|reactome:R-MMU-6798695	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:HwUDuY6Ev7csoTThxZCW8nJT88o10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q6ZPR4	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16728165|ensembl:ENSMUSP00000109809|uniprotkb:B2RUK3|uniprotkb:Q8C3E7	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:kcnt1_mouse(display_long)|uniprotkb:Kcnt1(gene name)|psi-mi:Kcnt1(display_short)|uniprotkb:Kiaa1422(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000058740(gene)|ensembl:ENSMUST00000114172(transcript)|go:"GO:0005228"(intracellular sodium activated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR013099(Ion transport 2)|mint:Q6ZPR4|refseq:NP_001289280.1|refseq:NP_780671.2	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:dqty8xDH9pIQhzgbYTeSOo4tLjA10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:P39087	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-396914|uniprotkb:Q60933|ensembl:ENSMUSP00000101124|ensembl:ENSMUSP00000151921	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:grik2_mouse(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym)|uniprotkb:Glutamate receptor beta-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:XP_017169293.1|ensembl:ENSMUSG00000056073(gene)|ensembl:ENSMUST00000105484(transcript)|ensembl:ENSMUST00000218823(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|mint:P39087|reactome:R-MMU-451307|reactome:R-MMU-451308	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:6sgY8SzX07HzilLLeDg3pV+sXkc10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O35681	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-457995|uniprotkb:P97791|uniprotkb:Q80WV1	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:syt3_mouse(display_long)|uniprotkb:Syt3(gene name)|psi-mi:Syt3(display_short)|uniprotkb:Synaptotagmin III(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_001107588.1|refseq:NP_057872.3|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR028682|mint:O35681|interpro:IPR035892	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:mkfffZn3WWGhztw/udRiKd0LUJ010090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:O35099	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-777493|uniprotkb:Q14AY5|ensembl:ENSMUSP00000093485	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:m3k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:Map3k5(gene name)|psi-mi:Map3k5(display_short)|uniprotkb:Ask1(gene name synonym)|uniprotkb:Mekk5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	refseq:NP_032606.4|dip:DIP-38055N|ensembl:ENSMUSG00000071369(gene)|ensembl:ENSMUST00000095806(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010941"(regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902170"(cellular response to reactive nitrogen species)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:O35099|reactome:R-MMU-2559580	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:i1P8YtUNmpFauFUVVxzsMYoQYOw10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q9EPU0	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-6876715|ensembl:ENSMUSP00000075089|uniprotkb:Q3UG00|uniprotkb:Q6GYP5|uniprotkb:Q6PHQ5|uniprotkb:Q8K0N4|uniprotkb:Q99PR4	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:rent1_mouse(display_long)|uniprotkb:Upf1(gene name)|psi-mi:Upf1(display_short)|uniprotkb:Rent1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000058301(gene)|ensembl:ENSMUST00000075666(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016787"(hydrolase activity)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR018999|interpro:IPR027417|interpro:IPR040812|interpro:IPR041677|interpro:IPR041679|mint:Q9EPU0|reactome:R-MMU-975956|reactome:R-MMU-975957|go:"GO:0042162"(telomeric DNA binding)|refseq:XP_006509667.1|refseq:XP_006509668.1|refseq:NP_001116301.1|refseq:NP_109605.2|dip:DIP-60114N	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:rwd4XXdf5Uqjtgao/zILckKP8AM10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q64105	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-26470795|uniprotkb:Q63996	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:spre_mouse(display_long)|uniprotkb:Spr(gene name)|psi-mi:Spr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	go:"GO:0004757"(sepiapterin reductase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006558"(L-phenylalanine metabolic process)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0010033"(response to organic substance)|go:"GO:0019889"(pteridine metabolic process)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046146"(tetrahydrobiopterin metabolic process)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050882"(voluntary musculoskeletal movement)|rcsb pdb:1NAS|rcsb pdb:1OAA|rcsb pdb:1SEP|reactome:R-MMU-1474151|reactome:R-MMU-203615|mint:Q64105|interpro:IPR036291|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR006393(Sepiapterin reductase)	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:Y4ePCWcq2RI0t59kgHibLyHd6yM10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6NZM9	uniprotkb:Q8C3F2	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	intact:EBI-16728136|ensembl:ENSMUSP00000073082|uniprotkb:Q3U0F6	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:f120c_mouse(display_long)|uniprotkb:Protein FAM120C(gene name synonym)|uniprotkb:Fam120c(gene name)|psi-mi:Fam120c(display_short)|uniprotkb:ORF34(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473528|imex:IM-28526-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	ensembl:ENSMUSG00000025262(gene)|go:"GO:0005634"(nucleus)|interpro:IPR026784|interpro:IPR026785|interpro:IPR029060|mint:Q8C3F2|ensembl:ENSMUST00000073364(transcript)|refseq:NP_932773.2	-	-	-	figure legend:ST4|comment:a uniform cutoff of ≥0.95 was used for Hdac4 in all striatum conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	rogid:7t8xHEO+ShbLsdqIbH6xQm7UcPw10090	rigid:6zzz9zdPE/SSiqELr7UmZ8DEuQY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9R049	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-3648125|uniprotkb:Q8K008|uniprotkb:Q99LH5	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:amfr_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase AMFR(gene name synonym)|uniprotkb:Amfr(gene name)|psi-mi:Amfr(display_short)|uniprotkb:Autocrine motility factor receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	mint:Q9R049|refseq:NP_035917.2|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0009987"(cellular process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:2000638"(regulation of SREBP signaling pathway)|reactome:R-MMU-532668|interpro:IPR040675	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:WllN35rkcf63zUF7TI4pQwTYfOI10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9WVA4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8346396|intact:MINT-1851835|uniprotkb:Q91VU2|uniprotkb:Q6A0C6|uniprotkb:Q3TIB8|uniprotkb:Q78ZX2|ensembl:ENSMUSP00000106859|ensembl:ENSMUSP00000106861	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tagl2_mouse(display_long)|uniprotkb:Tagln2(gene name)|psi-mi:Tagln2(display_short)|uniprotkb:Kiaa0120(gene name synonym)|uniprotkb:SM22-beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_848713.1|ensembl:ENSMUSG00000026547(gene)|ensembl:ENSMUST00000111228(transcript)|ensembl:ENSMUST00000111230(transcript)|go:"GO:0030855"(epithelial cell differentiation)|interpro:IPR000557(Calponin repeat)|interpro:IPR001061("Transgelin (SM22-alpha)")|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR036872|mint:Q9WVA4|reactome:R-MMU-114608	-	-	comment:mint	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:DZGhGeV0F0S2D9Qfr9+WRqBEqhs10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:G3X9C2	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8361411|uniprotkb:Q8BT24|intact:MINT-4112347|ensembl:ENSMUSP00000159104	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fbx50_mouse(display_long)|uniprotkb:Nccrp1(gene name)|psi-mi:Nccrp1(display_short)|uniprotkb:Fbxo50(gene name synonym)|uniprotkb:NCC receptor protein 1(gene name synonym)|uniprotkb:Non-specific cytotoxic cell receptor protein 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001074584.1|ensembl:ENSMUSG00000047586(gene)|ensembl:ENSMUST00000239002(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006516"(glycoprotein catabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR007397(F-box associated region)|interpro:IPR008979(Galactose-binding like)|interpro:IPR039752|mint:G3X9C2	-	-	comment:"fragmentation type: fragment"|comment:mint	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:VtqSzYh4SI+hDRWKT0U9ByaNKSM10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P04186	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8346300|intact:MINT-1865229|ensembl:ENSMUSP00000119977	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:cfab_mouse(display_long)|uniprotkb:Cfb(gene name)|psi-mi:Cfb(display_short)|uniprotkb:Bf(gene name synonym)|uniprotkb:H2-Bf(gene name synonym)|uniprotkb:C3/C5 convertase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000090231(gene)|ensembl:ENSMUST00000128767(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0097066"(response to thyroid hormone)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011360(Complement B/C2)|interpro:IPR018114|interpro:IPR028341|interpro:IPR033116|interpro:IPR035976|interpro:IPR036465|mint:P04186|reactome:R-MMU-173736|reactome:R-MMU-174577|reactome:R-MMU-977606	-	-	comment:mint|function:"Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase"	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:ZIuU2m3OfhhdoW+STWEfOv2i9QM10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q61704	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8320806|intact:MINT-4099088|uniprotkb:E9QME9|uniprotkb:Q91WG9|ensembl:ENSMUSP00000006697	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:itih3_mouse(display_long)|uniprotkb:Itih3(gene name)|psi-mi:Itih3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032433.2|ensembl:ENSMUSG00000006522(gene)|ensembl:ENSMUST00000006697(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010600(Inter-alpha-trypsin inhibitor heavy chain, C-terminal)|interpro:IPR013694(Vault protein inter-alpha-trypsin)|interpro:IPR036465|mint:Q61704|reactome:R-MMU-114608	-	-	function:May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes|comment:mint	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Pdi9OY15tRMIbi72dbN6I0+9U1A10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P19221	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8375972|intact:MINT-4137721|ensembl:ENSMUSP00000028681	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:thrb_mouse(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Cf2(gene name synonym)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_034298.1|dip:DIP-60968N|ensembl:ENSMUSG00000027249(gene)|ensembl:ENSMUST00000028681(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|interpro:IPR035972|interpro:IPR037111|interpro:IPR038178|interpro:IPR043504|mint:P19221|rcsb pdb:2OCV|rcsb pdb:2PUX|rcsb pdb:2PV9|rcsb pdb:3EDX|rcsb pdb:3HK3|rcsb pdb:3HK6|rcsb pdb:3HKI|reactome:R-MMU-140837|reactome:R-MMU-140875|reactome:R-MMU-159740|reactome:R-MMU-159763|reactome:R-MMU-159782|reactome:R-MMU-202733|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-456926|reactome:R-MMU-76009|reactome:R-MMU-977606	-	-	comment:mint|function:Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:amZ+Pl0pNliSHuykYcjQLfqb1vw10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q2TPA8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8346446|uniprotkb:Q3ULY5|uniprotkb:Q3UVZ3|intact:MINT-1860458|uniprotkb:Q99LV2|uniprotkb:Q8C3H3|ensembl:ENSMUSP00000030078	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:hsdl2_mouse(display_long)|uniprotkb:Hsdl2(gene name)|psi-mi:Hsdl2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_077217.2|ensembl:ENSMUSG00000028383(gene)|ensembl:ENSMUST00000030078(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR003033(Sterol-binding)|interpro:IPR036291|interpro:IPR036527|mint:Q2TPA8	-	-	comment:mint	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:EuUAecUkC7gRKu9bZnI12W9iz6w10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:O88783	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8391075|uniprotkb:Q3UV80|intact:MINT-4105665|uniprotkb:Q3UTQ2|ensembl:ENSMUSP00000083204	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fa5_mouse(display_long)|uniprotkb:F5(gene name)|psi-mi:F5(display_short)|uniprotkb:Activated protein C cofactor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032002.1|ensembl:ENSMUSG00000026579(gene)|ensembl:ENSMUST00000086040(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0031091"(platelet alpha granule)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011707(Multicopper oxidase, type 3)|interpro:IPR024715|interpro:IPR033138|mint:O88783|reactome:R-MMU-114608|reactome:R-MMU-140875|reactome:R-MMU-204005|reactome:R-MMU-381426|reactome:R-MMU-5694530|reactome:R-MMU-8957275	-	-	comment:mint	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:uKDUvdqfAad11uLZ1qznjhrHu+410090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9D4F8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-7780439|ensembl:ENSMUSP00000044049|intact:UNK-5542993	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp4_mouse(display_long)|uniprotkb:Tubgcp4(gene name)|psi-mi:Tubgcp4(display_short)|uniprotkb:D2Ertd435e(gene name synonym)|uniprotkb:Gcp4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000027263(gene)|ensembl:ENSMUST00000039541(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005813"(centrosome)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0055037"(recycling endosome)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|interpro:IPR042241|mint:Q9D4F8|reactome:R-MMU-380270|reactome:R-MMU-380320|go:"GO:0005874"(microtubule)|refseq:NP_700436.1	-	-	function:Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome|comment:mint	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:uoyvScV5OQTR+AqUMMIYMhe/a/Q10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q921H8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8330006|intact:MINT-1858351|ensembl:ENSMUSP00000042351	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:thika_mouse(display_long)|uniprotkb:Acetyl-CoA C-myristoyltransferase(gene name synonym)|uniprotkb:Acaa1a(gene name)|psi-mi:Acaa1a(display_short)|uniprotkb:Acaa1(gene name synonym)|uniprotkb:Beta-ketothiolase A(gene name synonym)|uniprotkb:Acetyl-CoA acyltransferase A(gene name synonym)|uniprotkb:Peroxisomal 3-oxoacyl-CoA thiolase A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_570934.1|refseq:XP_006511986.1|ensembl:ENSMUSG00000036138(gene)|ensembl:ENSMUST00000039784(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008775"(acetate CoA-transferase activity)|go:"GO:0010124"(phenylacetate catabolic process)|go:"GO:0016401"(palmitoyl-CoA oxidase activity)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:Q921H8|reactome:R-MMU-2046106|reactome:R-MMU-390247|reactome:R-MMU-6798695|reactome:R-MMU-9033241	-	-	comment:mint	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:A7f6/enaS9RJZ+DDXxVXXa/9vTU10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q925E7	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8322442|intact:MINT-4086270|uniprotkb:Q6ZPN5|ensembl:ENSMUSP00000040321	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:2abd_mouse(display_long)|uniprotkb:Ppp2r2d(gene name)|psi-mi:Ppp2r2d(display_short)|uniprotkb:D7Ertd753e(gene name synonym)|uniprotkb:Kiaa1541(gene name synonym)|uniprotkb:PP2A subunit B isoform delta(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-delta(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-delta(gene name synonym)|uniprotkb:PP2A subunit B isoform R2-delta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_080667.1|ensembl:ENSMUSG00000041769(gene)|ensembl:ENSMUST00000041097(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005829"(cytosol)|go:"GO:0010458"(exit from mitosis)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0051301"(cell division)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:Q925E7	-	-	function:The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment|comment:mint	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Zh/H8rSp0CYazGt4SwUz+532bJQ10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8R4H2	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8046267|intact:MINT-1774761|uniprotkb:E9QPW9|uniprotkb:Q80U18|ensembl:ENSMUSP00000072547	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:arhgc_mouse(display_long)|uniprotkb:Arhgef12(gene name)|psi-mi:Arhgef12(display_short)|uniprotkb:Kiaa0382(gene name synonym)|uniprotkb:Larg(gene name synonym)|uniprotkb:Leukemia-associated RhoGEF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:XP_006510649.1|ensembl:ENSMUSG00000059495(gene)|ensembl:ENSMUST00000072767(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037801|interpro:IPR037884|interpro:IPR041020|mint:Q8R4H2|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148	-	-	comment:mint|function:"May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13"	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:5ZclDYjaUBilqiB548/6M5KlhVg10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P51660	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8328056|intact:MINT-1859569|intact:MINT-2512164|uniprotkb:Q9DBM3|ensembl:ENSMUSP00000025385	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:dhb4_mouse(display_long)|uniprotkb:Hsd17b4(gene name)|psi-mi:Hsd17b4(display_short)|uniprotkb:Edh17b4(gene name synonym)|uniprotkb:Multifunctional protein 2(gene name synonym)|uniprotkb:D-bifunctional protein(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032318.2|ensembl:ENSMUSG00000024507(gene)|ensembl:ENSMUST00000025385(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0004303"(estradiol 17-beta-dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0033989"(3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity)|go:"GO:0036111"(very long-chain fatty-acyl-CoA metabolic process)|go:"GO:0036112"(medium-chain fatty-acyl-CoA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0060009"(Sertoli cell development)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR002539(MaoC-like dehydratase)|interpro:IPR003033(Sterol-binding)|interpro:IPR020904|interpro:IPR029069|interpro:IPR036291|interpro:IPR036527|mint:P51660|reactome:R-MMU-193368|reactome:R-MMU-2046106|reactome:R-MMU-389887|reactome:R-MMU-390247|reactome:R-MMU-9033241	-	-	function:Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids|comment:mint	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:71hLYwG2pK+0vOd5eF+qYIa7J5I10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P97350	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-4280963|uniprotkb:B2RSX3|ensembl:ENSMUSP00000027667|ensembl:ENSMUSP00000128418	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:pkp1_mouse(display_long)|uniprotkb:Pkp1(gene name)|psi-mi:Pkp1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001300630.1|ensembl:ENSMUSG00000026413(gene)|ensembl:ENSMUST00000027667(transcript)|ensembl:ENSMUST00000163260(transcript)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030057"(desmosome)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0045296"(cadherin binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028432|interpro:IPR028435|mint:P97350|reactome:R-MMU-351906|reactome:R-MMU-6798695|reactome:R-MMU-6805567|reactome:R-MMU-6809371|refseq:NP_062619.1	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:0u1sErZ6PA3jKsFg7DQ9NlLMevI10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P06151	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-444940|ensembl:ENSMUSP00000036386|ensembl:ENSMUSP00000103267	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:ldha_mouse(display_long)|uniprotkb:LDH muscle subunit(gene name synonym)|uniprotkb:Ldha(gene name)|psi-mi:Ldha(display_short)|uniprotkb:Ldh-1(gene name synonym)|uniprotkb:Ldh1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_034829.1|ensembl:ENSMUSG00000063229(gene)|ensembl:ENSMUST00000005051(transcript)|ensembl:ENSMUST00000048209(transcript)|go:"GO:0004457"(lactate dehydrogenase activity)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019244"(lactate biosynthetic process from pyruvate)|go:"GO:0019661"(glucose catabolic process to lactate via pyruvate)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0042802"(identical protein binding)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P06151|reactome:R-MMU-70268	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:IErFuOIWq53/XyIxWgUyVi76VnM10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q3UHB8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-16731180|ensembl:ENSMUSP00000072982|uniprotkb:Q6NXJ5	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:cc177_mouse(display_long)|uniprotkb:Ccdc177(gene name)|psi-mi:Ccdc177(display_short)|uniprotkb:Gm1568(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000062961(gene)|ensembl:ENSMUST00000073251(transcript)|interpro:IPR029090|mint:Q3UHB8|refseq:NP_001008423.2	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:objGQkpHL5Pr4FZHhKDHYGjAVUU10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:O09061	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-991712|uniprotkb:Q62038|uniprotkb:Q62039|ensembl:ENSMUSP00000014913	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:psb1_mouse(display_long)|uniprotkb:Proteasome component C5(gene name synonym)|uniprotkb:Macropain subunit C5(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C5(gene name synonym)|uniprotkb:Proteasome gamma chain(gene name synonym)|uniprotkb:Psmb1(gene name)|psi-mi:Psmb1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000014769(gene)|ensembl:ENSMUST00000014913(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035202|rcsb pdb:3UNB|rcsb pdb:3UNE|rcsb pdb:3UNF|rcsb pdb:3UNH|rcsb pdb:5L65|rcsb pdb:5L66|rcsb pdb:5L67|rcsb pdb:5L68|rcsb pdb:5L69|rcsb pdb:5L6A|rcsb pdb:5L6B|rcsb pdb:5L6C|reactome:R-MMU-1169091|reactome:R-MMU-1234176|reactome:R-MMU-1236978|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-187577|reactome:R-MMU-195253|reactome:R-MMU-202424|reactome:R-MMU-2467813|reactome:R-MMU-2871837|reactome:R-MMU-349425|reactome:R-MMU-350562|reactome:R-MMU-382556|reactome:R-MMU-450408|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-4641258|reactome:R-MMU-5358346|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-5668541|reactome:R-MMU-5676590|reactome:R-MMU-5687128|reactome:R-MMU-5689603|mint:O09061|reactome:R-MMU-5689880|reactome:R-MMU-6798695|reactome:R-MMU-68827|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69481|reactome:R-MMU-69601|reactome:R-MMU-8852276|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939236|reactome:R-MMU-8939902|reactome:R-MMU-8941858|reactome:R-MMU-8948751|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-983168|reactome:R-MMU-75815|refseq:NP_035315.1	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:CIHxzlrtwKh+f15z5Uf8Bv4yJ0o10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P23506	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2551550|uniprotkb:Q810R4	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:pimt_mouse(display_long)|uniprotkb:Protein-beta-aspartate methyltransferase(gene name synonym)|uniprotkb:Protein L-isoaspartyl/D-aspartyl methyltransferase(gene name synonym)|uniprotkb:L-isoaspartyl protein carboxyl methyltransferase(gene name synonym)|uniprotkb:Pcmt1(gene name)|psi-mi:Pcmt1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0004719"("protein-L-isoaspartate (D-aspartate) O-methyltransferase activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0046498"(S-adenosylhomocysteine metabolic process)|go:"GO:0046500"(S-adenosylmethionine metabolic process)|reactome:R-MMU-5676934|go:"GO:0005615"(extracellular space)|interpro:IPR000682("Protein-L-isoaspartate(D-aspartate) O-methyltransferase")|interpro:IPR029063|mint:P23506	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:/kF80VzFY1AYBQh3RU7s42+r6mU10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9WUR2	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2794295|uniprotkb:Q99M61|uniprotkb:Q9D785|ensembl:ENSMUSP00000131735	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:eci2_mouse(display_long)|uniprotkb:Eci2(gene name)|psi-mi:Eci2(display_short)|uniprotkb:Dodecenoyl-CoA isomerase(gene name synonym)|uniprotkb:"Delta(3),delta(2)-enoyl-CoA isomerase"(gene name synonym)|uniprotkb:Peci(gene name synonym)|uniprotkb:Peroxisomal 3,2-trans-enoyl-CoA isomerase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001103801.1|refseq:NP_035998.2|refseq:XP_006516736.1|refseq:XP_006516737.1|refseq:XP_006516738.1|refseq:XP_006516739.1|refseq:XP_006516740.1|ensembl:ENSMUSG00000021417(gene)|ensembl:ENSMUST00000171229(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0004165"("delta(3)-delta(2)-enoyl-CoA isomerase activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0016863"(intramolecular oxidoreductase activity, transposing C=C bonds)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000582(Acyl-CoA-binding protein, ACBP)|interpro:IPR001753(Crotonase, core)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR022408|interpro:IPR029045|interpro:IPR035984|mint:Q9WUR2|reactome:R-MMU-390247|reactome:R-MMU-9033241|go:"GO:0006635"(fatty acid beta-oxidation)	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:nHPcS0mXXHwtPjuxHZLEOsf99sk10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q61598	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-6665490|ensembl:ENSMUSP00000152454|uniprotkb:Q541Z9|uniprotkb:Q8C530|uniprotkb:Q9D8M9	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gdib_mouse(display_long)|uniprotkb:Gdi2(gene name)|psi-mi:Gdi2(display_short)|uniprotkb:Gdi3(gene name synonym)|uniprotkb:GDI-3(gene name synonym)|uniprotkb:Guanosine diphosphate dissociation inhibitor 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0005093"(Rab GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045202"(synapse)|interpro:IPR000806(Rab GDI protein)|interpro:IPR018203|interpro:IPR036188|mint:Q61598|reactome:R-MMU-6798695|reactome:R-MMU-8876198|ensembl:ENSMUSG00000021218(gene)|ensembl:ENSMUST00000223396(transcript)|refseq:NP_032138.3|dip:DIP-348N	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:+ngZz9q02lDEdFO543w/yl6chgc10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P62827	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-286564|uniprotkb:Q3U954|uniprotkb:Q811M2|uniprotkb:Q86V08|uniprotkb:P17080|uniprotkb:P28746|uniprotkb:P28747|uniprotkb:Q9UDJ5|uniprotkb:Q9CSP3|uniprotkb:Q9CWI7|uniprotkb:Q9CZA2|uniprotkb:Q9UEU9|ensembl:ENSMUSP00000031383|ensembl:ENSMUSP00000106975	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:ran_mouse(display_long)|uniprotkb:GTPase Ran(gene name synonym)|uniprotkb:Ras-related nuclear protein(gene name synonym)|uniprotkb:Ras-like protein TC4(gene name synonym)|uniprotkb:Ran(gene name)|psi-mi:Ran(display_short)|uniprotkb:Rasl2-8(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_033417.1|refseq:XP_006504343.1|ensembl:ENSMUSG00000029430(gene)|ensembl:ENSMUST00000031383(transcript)|ensembl:ENSMUST00000111343(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0002177"(manchette)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030496"(midbody)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034629"|go:"GO:0036126"(sperm flagellum)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0061015"(snRNA import into nucleus)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:1902570"(protein localization to nucleolus)|interpro:IPR001806(Ras GTPase)|interpro:IPR002041(Ran GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62827|reactome:R-MMU-1655829|reactome:R-MMU-5578749|reactome:R-MMU-9615933	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:trIUv5n3nI5d0rkfDTgw/6ubxMA10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q61316	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2013169	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:hsp74_mouse(display_long)|uniprotkb:Hspa4(gene name)|psi-mi:Hspa4(display_short)|uniprotkb:Apg2(gene name synonym)|uniprotkb:Hsp110(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	dip:DIP-46965N|mint:Q61316|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042052|interpro:IPR043129|reactome:R-MMU-3371453	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:LEZQFUhx6IFE7HTuGpJQ9TQLL9Y10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P11087	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1634830|uniprotkb:Q53WT0|uniprotkb:Q60635|uniprotkb:Q61367|uniprotkb:Q61427|uniprotkb:Q63919|uniprotkb:Q6PCL3|uniprotkb:Q810J9|ensembl:ENSMUSP00000001547	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:co1a1_mouse(display_long)|uniprotkb:Col1a1(gene name)|psi-mi:Col1a1(display_short)|uniprotkb:Cola1(gene name synonym)|uniprotkb:Alpha-1 type I collagen(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_031768.2|ensembl:ENSMUSG00000001506(gene)|ensembl:ENSMUST00000001547(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0001958"(endochondral ossification)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005584"(collagen type I trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0015031"(protein transport)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032355"(response to estradiol)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034505"(tooth mineralization)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043588"(skin development)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044691"(tooth eruption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0051591"(response to cAMP)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071306"(cellular response to vitamin E)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902618"(cellular response to fluoride)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR008160(Collagen triple helix repeat)|mint:P11087|reactome:R-MMU-114604|reactome:R-MMU-1442490|reactome:R-MMU-1474244|reactome:R-MMU-1650814|reactome:R-MMU-198933|reactome:R-MMU-2022090|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-2214320|reactome:R-MMU-2243919|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-430116|reactome:R-MMU-75892|reactome:R-MMU-76009|reactome:R-MMU-8874081|reactome:R-MMU-8948216|go:"GO:0002020"(protease binding)	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:mZrc8e1VDJc4u6y4zXOj0glFj9410090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P97298	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26473750|ensembl:ENSMUSP00000000769|uniprotkb:O70629|uniprotkb:O88691	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:pedf_mouse(display_long)|uniprotkb:Serpinf1(gene name)|psi-mi:Serpinf1(display_short)|uniprotkb:Pedf(gene name synonym)|uniprotkb:Sdf3(gene name synonym)|uniprotkb:Caspin(gene name synonym)|uniprotkb:Serpin F1(gene name synonym)|uniprotkb:Stromal cell-derived factor 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0007568"(aging)|go:"GO:0007614"(short-term memory)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030424"(axon)|go:"GO:0042470"(melanosome)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043203"(axon hillock)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0005615"(extracellular space)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901652"(response to peptide)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033832|interpro:IPR036186|interpro:IPR042178|go:"GO:0071279"(cellular response to cobalt ion)|interpro:IPR042185|mint:P97298|rcsb pdb:6LOS|ensembl:ENSMUSG00000000753(gene)|ensembl:ENSMUST00000000769(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|refseq:NP_035470.3	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:erc5qR742qYfQ8CBBCHeKRbrUSc10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q99JP6	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-6272061|ensembl:ENSMUSP00000117033|uniprotkb:D3Z6N9|uniprotkb:Q9Z215	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:home3_mouse(display_long)|uniprotkb:Homer3(gene name)|psi-mi:Homer3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000003573(gene)|ensembl:ENSMUST00000140212(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q99JP6|reactome:R-MMU-6794361|refseq:NP_001139625.1|refseq:NP_036114.2	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:7IOPI8VTi6aKK/I0tl4AiUUIXIU10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P10107	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-647848|ensembl:ENSMUSP00000025561|ensembl:ENSMUSP00000158305	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:anxa1_mouse(display_long)|uniprotkb:Annexin-1(gene name synonym)|uniprotkb:Annexin I(gene name synonym)|uniprotkb:Lipocortin I(gene name synonym)|uniprotkb:Calpactin II(gene name synonym)|uniprotkb:Chromobindin-9(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Phospholipase A2 inhibitory protein(gene name synonym)|uniprotkb:Anxa1(gene name)|psi-mi:Anxa1(display_short)|uniprotkb:Anx1(gene name synonym)|uniprotkb:Lpc1(gene name synonym)|uniprotkb:Lpc-1(gene name synonym)|uniprotkb:Calpactin-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_034860.2|ensembl:ENSMUSG00000024659(gene)|ensembl:ENSMUST00000025561(transcript)|ensembl:ENSMUST00000235280(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002250"(adaptive immune response)|go:"GO:0045629"(negative regulation of T-helper 2 cell differentiation)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070459"(prolactin secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900138"(negative regulation of phospholipase A2 activity)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001464(Annexin)|interpro:IPR002388(Annexin, type I)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P10107|reactome:R-MMU-416476|reactome:R-MMU-418594|reactome:R-MMU-444473|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030850"(prostate gland development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031514"(motile cilium)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032355"(response to estradiol)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032652"(regulation of interleukin-1 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0042063"(gliogenesis)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042629"(mast cell granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044849"(estrous cycle)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:V9sZHzXdA0iCeXidE8a0ahnWFoE10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q6GQT1	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26473702|ensembl:ENSMUSP00000032203|uniprotkb:E9QMQ7|uniprotkb:Q811S0	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:a2mg_mouse(display_long)|uniprotkb:A2m(gene name)|psi-mi:A2m(display_short)|uniprotkb:A2mp(gene name synonym)|uniprotkb:Alpha-2-macroglobulin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000030111(gene)|ensembl:ENSMUST00000032203(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007565"(female pregnancy)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048863"(stem cell differentiation)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR019742|interpro:IPR036595|interpro:IPR040839|interpro:IPR041555|interpro:IPR041813|mint:Q6GQT1|reactome:R-MMU-114608|reactome:R-MMU-140837|reactome:R-MMU-1474228|reactome:R-MMU-8963896|refseq:NP_783327.2	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:uf5Mk7VLjnfs0IkZp4CoUuuAkb010090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q921I1	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-761948|uniprotkb:O35421|uniprotkb:Q3UBW7|uniprotkb:Q58E69|uniprotkb:Q61803|uniprotkb:Q62357|uniprotkb:Q62358|uniprotkb:Q62359|uniprotkb:Q63915|uniprotkb:Q64515|uniprotkb:Q8VII5|uniprotkb:Q922C0|ensembl:ENSMUSP00000108264|ensembl:ENSMUSP00000035158	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:trfe_mouse(display_long)|uniprotkb:Siderophilin(gene name synonym)|uniprotkb:Beta-1 metal-binding globulin(gene name synonym)|uniprotkb:Tf(gene name)|psi-mi:Tf(display_short)|uniprotkb:Trf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_598738.1|ensembl:ENSMUSG00000032554(gene)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0097433"(dense body)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR001156(Peptidase S60, transferrin lactoferrin)|interpro:IPR016357(Transferrin)|interpro:IPR018195|interpro:IPR030685|mint:Q921I1|reactome:R-MMU-114608|reactome:R-MMU-381426|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8957275|reactome:R-MMU-917937|reactome:R-MMU-917977|ensembl:ENSMUST00000035158(transcript)|ensembl:ENSMUST00000112645(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007015"(actin filament organization)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030120"(vesicle coat)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0031982"(vesicle)|go:"GO:0034756"(regulation of iron ion transport)|go:"GO:0034986"(iron chaperone activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0045178"(basal part of cell)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0055037"(recycling endosome)|go:"GO:0009986"(cell surface)	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:V7U4fb+43G8NBKnZT/9PR+9HiQk10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P01942	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-494191	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:hba_mouse(display_long)|uniprotkb:Hemoglobin alpha chain(gene name synonym)|uniprotkb:Alpha-globin(gene name synonym)|uniprotkb:Hba(gene name)|psi-mi:Hba(display_short)|uniprotkb:Hba-a1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	dip:DIP-34118N|go:"GO:0048821"(erythrocyte development)|go:"GO:0098869"(cellular oxidant detoxification)|interpro:IPR000971(Globin, subset)|interpro:IPR002338(Haemoglobin, alpha)|interpro:IPR002339(Haemoglobin, pi)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|rcsb pdb:3HRW|reactome:R-MMU-1237044|reactome:R-MMU-1247673|reactome:R-MMU-2168880|reactome:R-MMU-9707564|reactome:R-MMU-9707616|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0009617"(response to bacterium)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|mint:P01942	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:PbMJ6ngi/QKo4CGt7XQMqTFT6RU10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P14152	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-494462|uniprotkb:Q3TP22|uniprotkb:Q80Y13|uniprotkb:Q9DB45|ensembl:ENSMUSP00000099938|ensembl:ENSMUSP00000159017	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mdhc_mouse(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:Mdh1(gene name)|psi-mi:Mdh1(display_short)|uniprotkb:Mor2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032644.3|refseq:NP_001303604.1|ensembl:ENSMUSG00000020321(gene)|ensembl:ENSMUST00000102874(transcript)|ensembl:ENSMUST00000239073(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0016615"(malate dehydrogenase activity)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0051287"(NAD binding)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|go:"GO:0006108"(malate metabolic process)|interpro:IPR022383|interpro:IPR036291|mint:P14152|reactome:R-MMU-70263	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Yq74ALpVIoaMM9Y2LUS4Sdmfztg10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P58252	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-773856|uniprotkb:Q544E4|ensembl:ENSMUSP00000046101	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:ef2_mouse(display_long)|uniprotkb:Eef2(gene name)|psi-mi:Eef2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_031933.1|ensembl:ENSMUSG00000034994(gene)|ensembl:ENSMUST00000047864(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006414"(translational elongation)|go:"GO:0007568"(aging)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016235"(aggresome)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051593"(response to folic acid)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031157|interpro:IPR035647|interpro:IPR041095|mint:P58252|reactome:R-MMU-156902|reactome:R-MMU-5358493|reactome:R-MMU-6798695	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:910/vo3IRjcncyPD4f43dPtS83o10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P18242	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-738562|ensembl:ENSMUSP00000121203	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:catd_mouse(display_long)|uniprotkb:Ctsd(gene name)|psi-mi:Ctsd(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_034113.1|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070001"(aspartic-type peptidase activity)|go:"GO:0070201"(regulation of establishment of protein localization)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR012848(Propeptide, peptidase A1)|go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033144|mint:P18242|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|reactome:R-MMU-1442490|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|reactome:R-MMU-2022377|reactome:R-MMU-2132295|reactome:R-MMU-6798695|go:"GO:0010008"(endosome membrane)|go:"GO:0016787"(hydrolase activity)|ensembl:ENSMUSG00000007891(gene)|ensembl:ENSMUST00000151120(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0004175"(endopeptidase activity)	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:PrpcvWCAFSmTF9ECBCB/zMV6d9M10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P32020	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-309563|uniprotkb:Q9DBM7|uniprotkb:A2APS2|uniprotkb:A2APS3|ensembl:ENSMUSP00000030340	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:scp2_mouse(display_long)|uniprotkb:Scp2(gene name)|psi-mi:Scp2(display_short)|uniprotkb:Scp-2(gene name synonym)|uniprotkb:Propanoyl-CoA C-acyltransferase(gene name synonym)|uniprotkb:Sterol carrier protein X(gene name synonym)|uniprotkb:SCP-chi(gene name synonym)|uniprotkb:Acetyl-CoA C-myristoyltransferase(gene name synonym)|uniprotkb:Non-specific lipid-transfer protein(gene name synonym)|uniprotkb:SCP-2/3-oxoacyl-CoA thiolase(gene name synonym)|uniprotkb:SCP-2/thiolase(gene name synonym)|uniprotkb:Straight-chain acyl-CoA oxidase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035457.1|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006701"(progesterone biosynthetic process)|go:"GO:0007031"(peroxisome organization)|go:"GO:0007568"(aging)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008526"(phosphatidylinositol transfer activity)|go:"GO:0010893"(positive regulation of steroid biosynthetic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032385"(positive regulation of intracellular cholesterol transport)|go:"GO:0032934"(sterol binding)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033814"(propanoyl-CoA C-acyltransferase activity)|go:"GO:0036042"(long-chain fatty acyl-CoA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045940"(positive regulation of steroid metabolic process)|go:"GO:0050632"(propionyl-CoA C2-trimethyltridecanoyltransferase activity)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|go:"GO:0070538"(oleic acid binding)|go:"GO:0071071"(regulation of phospholipid biosynthetic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0120019"(phosphatidylcholine transfer activity)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1901373"(lipid hydroperoxide transport)|go:"GO:1904109"(positive regulation of cholesterol import)|go:"GO:1904121"(phosphatidylethanolamine transfer activity)|interpro:IPR003033(Sterol-binding)|interpro:IPR016039(Thiolase-like)|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|interpro:IPR036527|mint:P32020|go:"GO:0006637"(acyl-CoA metabolic process)|ensembl:ENSMUSG00000028603(gene)|ensembl:ENSMUST00000030340(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:IpeZbl/Hw0r6QueEBBV8WBaMnNM10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P35441	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-6171593	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tsp1_mouse(display_long)|uniprotkb:Thbs1(gene name)|psi-mi:Thbs1(display_short)|uniprotkb:Tsp1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0043236"(laminin binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|reactome:R-MMU-114608|reactome:R-MMU-186797|reactome:R-MMU-216083|reactome:R-MMU-5173214|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016477"(cell migration)|interpro:IPR001881(EGF-like calcium-binding)|mint:P35441|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR017897|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:0j9TPpvxNW9TNMFkFCNo+9wD3fA10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P24270	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2924912|uniprotkb:Q3TXQ6|ensembl:ENSMUSP00000028610	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:cata_mouse(display_long)|uniprotkb:Cat(gene name)|psi-mi:Cat(display_short)|uniprotkb:Cas-1(gene name synonym)|uniprotkb:Cas1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0055093"(response to hyperoxia)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0080184"(response to phenylpropanoid)|interpro:IPR002226(Catalase)|interpro:IPR010582(Catalase-related)|interpro:IPR011614(Catalase, N-terminal)|interpro:IPR018028|interpro:IPR020835|interpro:IPR024708|interpro:IPR024711|interpro:IPR040333|mint:P24270|reactome:R-MMU-3299685|reactome:R-MMU-6798695|reactome:R-MMU-9033241|go:"GO:0051781"(positive regulation of cell division)|ensembl:ENSMUSG00000027187(gene)|ensembl:ENSMUST00000028610(transcript)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0004096"(catalase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009642"(response to light intensity)|go:"GO:0009650"(UV protection)|go:"GO:0010193"(response to ozone)|go:"GO:0010288"(response to lead ion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0016209"(antioxidant activity)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019899"(enzyme binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|refseq:NP_033934.2	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Ahsw8/VMIQAUw7mWuBSFRn9g/3M10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P52480	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-647785|uniprotkb:Q3TBV8|uniprotkb:Q3TBW5|uniprotkb:Q3TC59|uniprotkb:Q3U1X3|uniprotkb:Q3U5P6|uniprotkb:Q4VC20|uniprotkb:Q64484|uniprotkb:Q91YI8|uniprotkb:Q9CWB1|ensembl:ENSMUSP00000034834	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:kpym_mouse(display_long)|uniprotkb:Pkm(gene name)|psi-mi:Pkm(display_short)|uniprotkb:Pk3(gene name synonym)|uniprotkb:Pkm2(gene name synonym)|uniprotkb:Pykm(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035229.2|refseq:XP_006510918.1|refseq:NP_001240812.1|refseq:XP_011240975.1|dip:DIP-40536N|ensembl:ENSMUSG00000032294(gene)|ensembl:ENSMUST00000034834(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001889"(liver development)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042866"(pyruvate biosynthetic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043531"(ADP binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:1902912"(pyruvate kinase complex)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P52480|reactome:R-MMU-6798695|reactome:R-MMU-70171	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:SWQx3aPATcnlExhyy8afjcrB+xo10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P62962	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-647096|uniprotkb:P10924|ensembl:ENSMUSP00000018437	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:prof1_mouse(display_long)|uniprotkb:Profilin I(gene name synonym)|uniprotkb:Pfn1(gene name)|psi-mi:Pfn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035202.1|dip:DIP-38075N|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050821"(protein stabilization)|go:"GO:0051054"(positive regulation of DNA metabolic process)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060074"(synapse maturation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR005454(Profilin, Mammalian)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR029892|interpro:IPR036140|mint:P62962|reactome:R-MMU-376176|reactome:R-MMU-4086400|reactome:R-MMU-5663220|ensembl:ENSMUSG00000018293(gene)|ensembl:ENSMUST00000018437(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:nzOTw5XdywGrh+fA9AInGIexyGk10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8CAQ8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-776087|uniprotkb:Q66JS4|uniprotkb:Q7TNE2|uniprotkb:Q8C7V1|uniprotkb:Q8CCI0|uniprotkb:Q8CDA8|uniprotkb:Q9D9F6|ensembl:ENSMUSP00000066181	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mic60_mouse(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:Immt(gene name)|psi-mi:Immt(display_short)|uniprotkb:Mic60(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_083949.2|refseq:NP_001240617.1|refseq:NP_001240610.1|refseq:NP_001240616.1|dip:DIP-32050N|ensembl:ENSMUSG00000052337(gene)|ensembl:ENSMUST00000064062(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|mint:Q8CAQ8|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0042407"(cristae formation)|go:"GO:0043209"(myelin sheath)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:fW23bvuLqjLn5wIOu6ycDsh7O1k10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:E9Q8I9	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-16732044|ensembl:ENSMUSP00000084454|uniprotkb:Q4VA57|uniprotkb:Q5DTL4|uniprotkb:Q8BIW6|uniprotkb:Q8BUA0|uniprotkb:Q8CG91	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fry_mouse(display_long)|uniprotkb:Fry(gene name)|psi-mi:Fry(display_short)|uniprotkb:Kiaa4143(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000056602(gene)|ensembl:ENSMUST00000087204(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005938"(cell cortex)|go:"GO:0030427"(site of polarized growth)|go:"GO:0031175"(neuron projection development)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025481|interpro:IPR025614|interpro:IPR029473|interpro:IPR039867|mint:E9Q8I9|refseq:NP_766475.2|refseq:XP_006504993.1	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:fvduzhqkwcM9qmnWvPWAA1W8HqI10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P07724	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1183810|uniprotkb:Q3TV03|uniprotkb:Q61802|uniprotkb:Q8C7C7|uniprotkb:Q8C7H3|uniprotkb:Q8CG74|ensembl:ENSMUSP00000031314	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:albu_mouse(display_long)|uniprotkb:Alb(gene name)|psi-mi:Alb(display_short)|uniprotkb:Alb1(gene name synonym)|uniprotkb:Alb-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_033784.2|ensembl:ENSMUSG00000029368(gene)|ensembl:ENSMUST00000031314(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0019825"(oxygen binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0046010"(positive regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0051087"(chaperone binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072341"(modified amino acid binding)|go:"GO:0140272"(exogenous protein binding)|go:"GO:1903981"(enterobactin binding)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR020857|interpro:IPR020858|interpro:IPR021177|mint:P07724|reactome:R-MMU-114608|reactome:R-MMU-159418|reactome:R-MMU-189451|reactome:R-MMU-189483|reactome:R-MMU-2168880|reactome:R-MMU-381426|reactome:R-MMU-879518|reactome:R-MMU-8957275|reactome:R-MMU-8964058|reactome:R-MMU-9707564	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:R7zO/mB332rAl8J+WrXfsHzjSYs10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P09411	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1634776|uniprotkb:Q3TPE6|uniprotkb:Q3UKV8|uniprotkb:Q5XJE7|ensembl:ENSMUSP00000080302	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:pgk1_mouse(display_long)|uniprotkb:Pgk1(gene name)|psi-mi:Pgk1(display_short)|uniprotkb:Pgk-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032854.2|dip:DIP-51710N|ensembl:ENSMUSG00000062070(gene)|ensembl:ENSMUST00000081593(transcript)|go:"GO:0004618"(phosphoglycerate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0016310"(phosphorylation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031639"(plasminogen activation)|go:"GO:0043531"(ADP binding)|go:"GO:0045121"(membrane raft)|go:"GO:0047134"("protein-disulfide reductase (NAD(P)) activity")|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001576(Phosphoglycerate kinase)|interpro:IPR015824(Phosphoglycerate kinase, N-terminal)|interpro:IPR015911(Phosphoglycerate kinase, conserved site)|interpro:IPR036043|mint:P09411|rcsb pdb:4O3F|reactome:R-MMU-70171|reactome:R-MMU-70263	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:388hPtU1n0xYbopG53ZWslYTzuk10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P17182	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-299507|ensembl:ENSMUSP00000075513|ensembl:ENSMUSP00000079727|ensembl:ENSMUSP00000157807|uniprotkb:Q99KT7|uniprotkb:Q9DCY7	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:enoa_mouse(display_long)|uniprotkb:Eno1(gene name)|psi-mi:Eno1(display_short)|uniprotkb:Eno-1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000059040(gene)|ensembl:ENSMUSG00000063524(gene)|ensembl:ENSMUST00000076155(transcript)|ensembl:ENSMUST00000080926(transcript)|ensembl:ENSMUST00000235307(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030426"(growth cone)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051020"(GTPase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0099738"(cell cortex region)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P17182|reactome:R-MMU-70171|reactome:R-MMU-70263|refseq:NP_001020559.1|refseq:NP_075608.2|refseq:XP_006538588.2	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:YFpn/7GDB6vXgCYLSxvNns7FlT410090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P08249	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-773487|uniprotkb:Q0QF44|uniprotkb:Q8CF79|uniprotkb:Q8R1P0|ensembl:ENSMUSP00000019323	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mdhm_mouse(display_long)|uniprotkb:Mdh2(gene name)|psi-mi:Mdh2(display_short)|uniprotkb:Mor1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032643.2|ensembl:ENSMUSG00000019179(gene)|ensembl:ENSMUST00000019323(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016020"(membrane)|go:"GO:0016615"(malate dehydrogenase activity)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043621"(protein self-association)|go:"GO:0046554"("malate dehydrogenase (NADP+) activity")|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010097(Malate dehydrogenase, NAD-dependent, eukaryotes and gamma proteobacteria)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P08249|reactome:R-MMU-70263|reactome:R-MMU-71403	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:KG/ilme6qKXuXKp3BqXC5kQ0dM410090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P21550	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1634301|ensembl:ENSMUSP00000072620|ensembl:ENSMUSP00000104188|ensembl:ENSMUSP00000128714	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:enob_mouse(display_long)|uniprotkb:Eno3(gene name)|psi-mi:Eno3(display_short)|uniprotkb:Eno-3(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Muscle-specific enolase(gene name synonym)|uniprotkb:Skeletal muscle enolase(gene name synonym)|uniprotkb:Enolase 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001129534.1|refseq:NP_031959.1|refseq:NP_001263214.1|refseq:XP_006532225.1|ensembl:ENSMUSG00000060600(gene)|ensembl:ENSMUST00000072841(transcript)|ensembl:ENSMUST00000108548(transcript)|ensembl:ENSMUST00000170716(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0007568"(aging)|go:"GO:0016020"(membrane)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P21550|reactome:R-MMU-70171|reactome:R-MMU-70263	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:CN/5EMhCFqpjAxZ04UHwcLN+eRI10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P63330	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-397144|uniprotkb:O88591|uniprotkb:P13353|uniprotkb:Q5SNY5|ensembl:ENSMUSP00000020608	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:pp2aa_mouse(display_long)|uniprotkb:Ppp2ca(gene name)|psi-mi:Ppp2ca(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_062284.1|ensembl:ENSMUSG00000020349(gene)|ensembl:ENSMUST00000020608(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007498"(mesoderm development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1990405"(protein antigen binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:P63330|reactome:R-MMU-113501|reactome:R-MMU-1295596|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2995383|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-4641262|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6804757|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-9648025|reactome:R-MMU-975957	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:gpR5Fal3vi6O6cteeGwW72EuctY10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q6P1F6	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-997427|ensembl:ENSMUSP00000086640	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:2aba_mouse(display_long)|uniprotkb:PP2A subunit B isoform alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-alpha(gene name synonym)|uniprotkb:Ppp2r2a(gene name)|psi-mi:Ppp2r2a(display_short)|uniprotkb:PP2A subunit B isoform R2-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001192117.1|refseq:NP_082308.1|ensembl:ENSMUSG00000022052(gene)|ensembl:ENSMUST00000089230(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0043278"(response to morphine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:Q6P1F6|reactome:R-MMU-2995383|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-975957	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:evS6klM2alZXtMthVsshKkrNgiA10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8VCK3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-17170916|ensembl:ENSMUSP00000045901	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tbg2_mouse(display_long)|uniprotkb:Gamma-2-tubulin(gene name synonym)|uniprotkb:Tubg2(gene name)|psi-mi:Tubg2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000045007(gene)|ensembl:ENSMUST00000043654(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|interpro:IPR000217(Tubulin)|interpro:IPR002454(Gamma tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q8VCK3|reactome:R-MMU-380270|reactome:R-MMU-380320|refseq:NP_598789.1	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:ebQHblMVkTKA8wnY1ae2fdPzx8I10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9JL26	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-772250|uniprotkb:Q6KAN4|uniprotkb:Q9Z2V7|ensembl:ENSMUSP00000046296	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fmnl1_mouse(display_long)|uniprotkb:Formin-related protein(gene name synonym)|uniprotkb:Fmnl1(gene name)|psi-mi:Fmnl1(display_short)|uniprotkb:Frl(gene name synonym)|uniprotkb:Frl1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001071166.1|refseq:NP_062653.2|ensembl:ENSMUSG00000055805(gene)|ensembl:ENSMUST00000042286(transcript)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009987"(cellular process)|go:"GO:0016477"(cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027657|interpro:IPR042201|interpro:IPR043592|mint:Q9JL26|reactome:R-MMU-5663220|reactome:R-MMU-9013148|reactome:R-MMU-9013149	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:TStYWzz5LdFY4BeOWifTZyl6uTw10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8C0D4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472248|ensembl:ENSMUSP00000138585|uniprotkb:Q8BVP8	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:rhg12_mouse(display_long)|uniprotkb:Arhgap12(gene name)|psi-mi:Arhgap12(display_short)|uniprotkb:Rho-type GTPase-activating protein 12(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000041225(gene)|ensembl:ENSMUST00000182559(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035491|interpro:IPR036020|interpro:IPR036028|mint:Q8C0D4|rcsb pdb:6GVC|reactome:R-MMU-9013149|reactome:R-MMU-9013405|reactome:R-MMU-9013424|reactome:R-MMU-9035034|refseq:NP_001034781.1|refseq:NP_083553.2	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:daP4oZJo5g2WAFHv8quvfttZ0H810090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q5SRY7	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-11073522|uniprotkb:Q923H0|uniprotkb:Q3TLZ8|uniprotkb:Q3TGM9|uniprotkb:Q8K022|uniprotkb:Q8BY90|ensembl:ENSMUSP00000090893	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fbw1b_mouse(display_long)|uniprotkb:Fbxw11(gene name)|psi-mi:Fbxw11(display_short)|uniprotkb:Btrcp2(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:Fbw1b(gene name synonym)|uniprotkb:Fbxw1b(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001258276.1|refseq:NP_001258277.1|refseq:NP_001258278.1|refseq:NP_598776.1|ensembl:ENSMUSG00000020271(gene)|ensembl:ENSMUST00000093205(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048511"(rhythmic process)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q5SRY7|reactome:R-MMU-1169091|reactome:R-MMU-202424|reactome:R-MMU-2565942|reactome:R-MMU-2871837|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5676590|reactome:R-MMU-5684264|reactome:R-MMU-8951664|reactome:R-MMU-983168|dip:DIP-59921N	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:ahDg2ntR1uE9TEaFa8xgmsH3Ijg10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q76MZ3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-400413|ensembl:ENSMUSP00000007708	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:2aaa_mouse(display_long)|uniprotkb:Ppp2r1a(gene name)|psi-mi:Ppp2r1a(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_058587.1|go:"GO:0051306"(mitotic sister chromatid separation)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903538"(regulation of meiotic cell cycle process involved in oocyte maturation)|go:"GO:1990405"(protein antigen binding)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:Q76MZ3|rcsb pdb:2IAE|rcsb pdb:2PF4|rcsb pdb:3FGA|rcsb pdb:6EF4|reactome:R-MMU-113501|reactome:R-MMU-1295596|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-2995383|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-4641262|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6804757|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-8854518|reactome:R-MMU-9648025|reactome:R-MMU-975957|ensembl:ENSMUSG00000007564(gene)|ensembl:ENSMUST00000007708(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030425"(dendrite)|go:"GO:0045202"(synapse)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051232"(meiotic spindle elongation)|dip:DIP-29429N	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:0tnO11U1SNOOT46j23f7dim8O8k10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:G5E8P0	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2554025|ensembl:ENSMUSP00000104977|intact:EBI-11600212|uniprotkb:Q6PFC6|uniprotkb:Q6ZPK3|uniprotkb:Q8BWI2	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp6_mouse(display_long)|uniprotkb:Tubgcp6(gene name)|psi-mi:Tubgcp6(display_short)|uniprotkb:Kiaa1669(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001156791.1|ensembl:ENSMUSG00000051786(gene)|ensembl:ENSMUST00000109353(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR042241|mint:G5E8P0|reactome:R-MMU-380270|reactome:R-MMU-380320|interpro:IPR041470	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:o8N6a4n0HmcfpjPF0YcWNZVH39c10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P58854	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2551135|ensembl:ENSMUSP00000000776|uniprotkb:Q6PDQ9	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp3_mouse(display_long)|uniprotkb:Gcp3(gene name synonym)|uniprotkb:Tubgcp3(gene name)|psi-mi:Tubgcp3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	reactome:R-MMU-380320|ensembl:ENSMUSG00000000759(gene)|ensembl:ENSMUST00000000776(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005827"(polar microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:P58854|reactome:R-MMU-380270|refseq:NP_932148.1	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:qyzJzan6HpBMaAAOyhPM+94ecQA10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P83887	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2553410|ensembl:ENSMUSP00000048036|uniprotkb:Q9Z310	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tbg1_mouse(display_long)|uniprotkb:Tubg1(gene name)|psi-mi:Tubg1(display_short)|uniprotkb:Tubg(gene name synonym)|uniprotkb:Gamma-1-tubulin(gene name synonym)|uniprotkb:Gamma-tubulin complex component 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000035198(gene)|ensembl:ENSMUST00000043680(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005827"(polar microtubule)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005929"(cilium)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0055037"(recycling endosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000217(Tubulin)|interpro:IPR002454(Gamma tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|go:"GO:0005525"(GTP binding)|interpro:IPR037103|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518|mint:P83887|refseq:NP_598785.1	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:vuOzSmoj6s4iR1pV9zNfwxYjue810090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9WV30	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472334|ensembl:ENSMUSP00000116094|uniprotkb:E9Q0P3|uniprotkb:E9Q6U2|uniprotkb:G5E8N9|uniprotkb:Q91WY0|uniprotkb:Q9JLA1	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:nfat5_mouse(display_long)|uniprotkb:Nfat5(gene name)|psi-mi:Nfat5(display_short)|uniprotkb:Rel domain-containing transcription factor NFAT5(gene name synonym)|uniprotkb:T-cell transcription factor NFAT5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000003847(gene)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0010628"(positive regulation of gene expression)|ensembl:ENSMUST00000125721(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|interpro:IPR011539(Rel homology)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0005634"(nucleus)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0005654"(nucleoplasm)|interpro:IPR015646(Nuclear factor of activated T-cells 5)|interpro:IPR032397|interpro:IPR037059|mint:Q9WV30|refseq:NP_001273189.1|refseq:NP_061293.2|refseq:NP_598718.2|refseq:XP_006531255.1|refseq:XP_017168393.1	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Yf1n8cmeTkVMCL5aw+LQZwrAIcM10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8BUR9	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2553237|ensembl:ENSMUSP00000037557	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mzt1_mouse(display_long)|uniprotkb:Mzt1(gene name)|psi-mi:Mzt1(display_short)|uniprotkb:Mozart1(gene name synonym)|uniprotkb:Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUST00000042662(transcript)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0033566"(gamma-tubulin complex localization)|go:"GO:0051415"(microtubule nucleation by interphase microtubule organizing center)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR022214|mint:Q8BUR9|reactome:R-MMU-380270|reactome:R-MMU-380320|ensembl:ENSMUSG00000033186(gene)|refseq:NP_780454.1	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:a686Bpxk37Kl0gKKTz14f6sq6s410090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q921G8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2552389|ensembl:ENSMUSP00000026547|uniprotkb:G5E859	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp2_mouse(display_long)|uniprotkb:Gcp2(gene name synonym)|uniprotkb:Tubgcp2(gene name)|psi-mi:Tubgcp2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001272936.1|ensembl:ENSMUSG00000025474(gene)|ensembl:ENSMUST00000026547(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0001764"(neuron migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007420"(brain development)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:Q921G8|reactome:R-MMU-380270|reactome:R-MMU-380320|go:"GO:0000923"(equatorial microtubule organizing center)|refseq:NP_598516.2	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:rWPzsdt3ECnxr+ksi4MaH7okQ+M10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:E9Q557	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-688046|ensembl:ENSMUSP00000115062	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:desp_mouse(display_long)|uniprotkb:Dsp(gene name)|psi-mi:Dsp(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_076331.2|ensembl:ENSMUSG00000054889(gene)|ensembl:ENSMUST00000124830(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0002934"(desmosome organization)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030057"(desmosome)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042060"(wound healing)|go:"GO:0043588"(skin development)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0150105"(protein localization to cell-cell junction)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR028462|interpro:IPR035915|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:E9Q557|reactome:R-MMU-351906|reactome:R-MMU-6798695|reactome:R-MMU-6805567|reactome:R-MMU-6809371|reactome:R-MMU-9696264|reactome:R-MMU-9696273	-	-	comment:AfCS Y2H protein. Translated from nucleotide sequence.|comment:"Similar to DESP_HUMAN Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) (95%)"	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:AQF1MrZZW8M5RfagBI7P4b3qQPA10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P54071	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-773401|uniprotkb:Q8C2R9|uniprotkb:Q9EQK1|ensembl:ENSMUSP00000103007	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:idhp_mouse(display_long)|uniprotkb:Oxalosuccinate decarboxylase(gene name synonym)|uniprotkb:"NADP(+)-specific ICDH"(gene name synonym)|uniprotkb:IDP(gene name synonym)|uniprotkb:ICD-M(gene name synonym)|uniprotkb:Idh2(gene name)|psi-mi:Idh2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_766599.2|ensembl:ENSMUSG00000030541(gene)|ensembl:ENSMUST00000107384(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004448"(isocitrate dehydrogenase activity)|go:"GO:0004450"("isocitrate dehydrogenase (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0006741"(NADP biosynthetic process)|go:"GO:0051287"(NAD binding)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:1903976"(negative regulation of glial cell migration)|go:"GO:1904465"(negative regulation of matrix metallopeptidase secretion)|interpro:IPR004790(Isocitrate dehydrogenase NADP-dependent, eukaryotic)|interpro:IPR019818|interpro:IPR024084|mint:P54071|rcsb pdb:5H3E|rcsb pdb:5H3F|reactome:R-MMU-2151201|reactome:R-MMU-71403	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:CkBZHIePaNGTtcgyqEf03oczVM010090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q3UHD3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472278|ensembl:ENSMUSP00000082694|uniprotkb:B9EKJ2|uniprotkb:Q7TPP7|uniprotkb:Q8CHD2|uniprotkb:Q9CY74	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mtus2_mouse(display_long)|uniprotkb:Mtus2(gene name)|psi-mi:Mtus2(display_short)|uniprotkb:Cazip(gene name synonym)|uniprotkb:Kiaa0774(gene name synonym)|uniprotkb:Tip150(gene name synonym)|uniprotkb:Cardiac zipper protein(gene name synonym)|uniprotkb:Microtubule plus-end tracking protein TIP150(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000029651(gene)|ensembl:ENSMUST00000085558(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR033339|mint:Q3UHD3|refseq:NP_084196.4|refseq:XP_006504953.1	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:42tgoThcDyvR8GE7irQd8rHlKL410090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P33215	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2366213|uniprotkb:Q6NXV3|uniprotkb:Q8BN12|uniprotkb:Q8BN86|uniprotkb:Q8BQL9|uniprotkb:Q9CWK2|ensembl:ENSMUSP00000020163	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:nedd1_mouse(display_long)|uniprotkb:Nedd1(gene name)|psi-mi:Nedd1(display_short)|uniprotkb:Nedd-1(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032708.2|ensembl:ENSMUSG00000019988(gene)|ensembl:ENSMUST00000020163(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000922"(spindle pole)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0031109"(microtubule polymerization or depolymerization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045177"(apical part of cell)|go:"GO:0051301"(cell division)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P33215|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:xBFWC64fRlKEVonqdYWgcVEPK0010090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9QXL8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472305	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:ndk7_mouse(display_long)|uniprotkb:Nme7(gene name)|psi-mi:Nme7(display_short)|uniprotkb:nm23-M7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	reactome:R-MMU-380320|go:"GO:0003351"(epithelial cilium movement involved in extracellular fluid movement)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005813"(centrosome)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0060830"(ciliary receptor clustering involved in smoothened signaling pathway)|go:"GO:0060972"(left/right pattern formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|reactome:R-MMU-380270|mint:Q9QXL8|interpro:IPR034907|interpro:IPR036850|interpro:IPR011410(Nucleoside diphosphate kinase, NDK7)|interpro:IPR035525|interpro:IPR037993|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR006602(Region of unknown function DM10)	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:zkOjHmuz7jAgTi/5/MQYROLtVKg10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P01027	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-4281083|uniprotkb:Q80XP1|ensembl:ENSMUSP00000024988|uniprotkb:Q61370	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:co3_mouse(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:HSE-MSF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000024164(gene)|ensembl:ENSMUST00000024988(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008289"(lipid binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01027|rcsb pdb:6XZU|reactome:R-MMU-173736|reactome:R-MMU-174577|reactome:R-MMU-198933|reactome:R-MMU-375276|reactome:R-MMU-381426|reactome:R-MMU-418594|reactome:R-MMU-6798695|reactome:R-MMU-8957275|reactome:R-MMU-977606|refseq:NP_033908.2	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:VGFRYhKETrS9O7cyeJZyxBFgBL410090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9R0L6	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-4284371|uniprotkb:O70287|uniprotkb:Q3URH6|uniprotkb:Q7TMS7|uniprotkb:Q8C9V2|uniprotkb:Q91Y27|uniprotkb:Q91Y28|uniprotkb:Q91Y51|uniprotkb:Q9CRK8|uniprotkb:Q923L0|uniprotkb:Q9CT57|uniprotkb:E9QLK2|ensembl:ENSMUSP00000039709	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:pcm1_mouse(display_long)|uniprotkb:Pcm1(gene name)|psi-mi:Pcm1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_076151.2|refseq:XP_006509361.1|ensembl:ENSMUSG00000031592(gene)|ensembl:ENSMUST00000045218(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q9R0L6|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-5620912|reactome:R-MMU-8854518|reactome:R-MMU-380320	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:OT+ZOQY5pqQojMcLCWMIY+6zdl410090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9CQ25	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2552037|ensembl:ENSMUSP00000023351|ensembl:ENSMUSP00000113832	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mzt2_mouse(display_long)|uniprotkb:Fam128b(gene name synonym)|uniprotkb:Mozart2(gene name synonym)|uniprotkb:Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B(gene name synonym)|uniprotkb:Mzt2(gene name)|psi-mi:Mzt2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|interpro:IPR024332|ensembl:ENSMUSG00000022671(gene)|mint:Q9CQ25|reactome:R-MMU-380270|reactome:R-MMU-380320|ensembl:ENSMUST00000023351(transcript)|ensembl:ENSMUST00000117136(transcript)|refseq:NP_083630.1|refseq:XP_006522651.1	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:heL4NryOHurQ03jZtyHwM/D5Xe810090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P11276	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-641955|uniprotkb:G5E8B8|uniprotkb:Q61567|uniprotkb:Q61568|uniprotkb:Q61569|uniprotkb:Q64233|uniprotkb:Q80UI4|ensembl:ENSMUSP00000054499	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:finc_mouse(display_long)|uniprotkb:Fn1(gene name)|psi-mi:Fn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_034363.1|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P11276|rcsb pdb:1MFN|rcsb pdb:2MFN|reactome:R-MMU-114608|reactome:R-MMU-1474228|reactome:R-MMU-1474244|reactome:R-MMU-1566977|reactome:R-MMU-202733|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000170|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381426|reactome:R-MMU-5674135|reactome:R-MMU-8874081|reactome:R-MMU-8957275|ensembl:ENSMUSG00000026193(gene)|ensembl:ENSMUST00000055226(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005577"(fibrinogen complex)	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:qndGPG6vmzpIIkDuO1BrVRI1oPg10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q91VN4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-776230|uniprotkb:Q3UNQ1|uniprotkb:Q9D5I5|uniprotkb:Q9DAM8|ensembl:ENSMUSP00000032172	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mic25_mouse(display_long)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 6(gene name synonym)|uniprotkb:Mic25(gene name synonym)|uniprotkb:Chchd6(gene name)|psi-mi:Chchd6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001161208.1|refseq:NP_079627.3|ensembl:ENSMUSG00000030086(gene)|ensembl:ENSMUST00000032172(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|interpro:IPR042860|mint:Q91VN4	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Op64pUsaaQVJ4d+W9vkGMMkgI8810090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8BKN5	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-11075667|uniprotkb:Q8C083|uniprotkb:Q69Z75|uniprotkb:Q8BLJ9|uniprotkb:Q3U8X5|ensembl:ENSMUSP00000032627	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp5_mouse(display_long)|uniprotkb:Tubgcp5(gene name)|psi-mi:Tubgcp5(display_short)|uniprotkb:Kiaa1899(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_666302.2|ensembl:ENSMUSG00000033790(gene)|ensembl:ENSMUST00000032627(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008017"(microtubule binding)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|interpro:IPR042241|mint:Q8BKN5|reactome:R-MMU-380270|reactome:R-MMU-380320	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:1BOIJxOyERW8OOgl7YGHj9W2PMw10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9CQR4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-299825|ensembl:ENSMUSP00000006900	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:aco13_mouse(display_long)|uniprotkb:Acot13(gene name)|psi-mi:Acot13(display_short)|uniprotkb:Hotdog-fold thioesterase superfamily member 2(gene name synonym)|uniprotkb:Palmitoyl-CoA hydrolase(gene name synonym)|uniprotkb:Them2(gene name synonym)|uniprotkb:Thioesterase superfamily member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473798|imex:IM-28526-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000006717(gene)|ensembl:ENSMUST00000006900(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR003736(Phenylacetic acid degradation-related protein)|interpro:IPR006683(Thioesterase superfamily)|interpro:IPR029069|interpro:IPR039298|mint:Q9CQR4|rcsb pdb:2CY9|reactome:R-MMU-77289|refseq:NP_080066.1	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q20 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:jMok2ZPtX2ETleMlnA+90d/FVxs10090	rigid:x2+0fiP+gsfC3Z8SlqXK+jwXM80	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9R049	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-3648125|uniprotkb:Q8K008|uniprotkb:Q99LH5	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:amfr_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase AMFR(gene name synonym)|uniprotkb:Amfr(gene name)|psi-mi:Amfr(display_short)|uniprotkb:Autocrine motility factor receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	mint:Q9R049|refseq:NP_035917.2|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0009987"(cellular process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:2000638"(regulation of SREBP signaling pathway)|reactome:R-MMU-532668|interpro:IPR040675	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:WllN35rkcf63zUF7TI4pQwTYfOI10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8R4H2	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8046267|intact:MINT-1774761|uniprotkb:E9QPW9|uniprotkb:Q80U18|ensembl:ENSMUSP00000072547	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:arhgc_mouse(display_long)|uniprotkb:Arhgef12(gene name)|psi-mi:Arhgef12(display_short)|uniprotkb:Kiaa0382(gene name synonym)|uniprotkb:Larg(gene name synonym)|uniprotkb:Leukemia-associated RhoGEF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:XP_006510649.1|ensembl:ENSMUSG00000059495(gene)|ensembl:ENSMUST00000072767(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037801|interpro:IPR037884|interpro:IPR041020|mint:Q8R4H2|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148	-	-	comment:mint|function:"May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13"	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:5ZclDYjaUBilqiB548/6M5KlhVg10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q2TPA8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8346446|uniprotkb:Q3ULY5|uniprotkb:Q3UVZ3|intact:MINT-1860458|uniprotkb:Q99LV2|uniprotkb:Q8C3H3|ensembl:ENSMUSP00000030078	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:hsdl2_mouse(display_long)|uniprotkb:Hsdl2(gene name)|psi-mi:Hsdl2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_077217.2|ensembl:ENSMUSG00000028383(gene)|ensembl:ENSMUST00000030078(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR003033(Sterol-binding)|interpro:IPR036291|interpro:IPR036527|mint:Q2TPA8	-	-	comment:mint	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:EuUAecUkC7gRKu9bZnI12W9iz6w10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:O88783	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8391075|uniprotkb:Q3UV80|intact:MINT-4105665|uniprotkb:Q3UTQ2|ensembl:ENSMUSP00000083204	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fa5_mouse(display_long)|uniprotkb:F5(gene name)|psi-mi:F5(display_short)|uniprotkb:Activated protein C cofactor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032002.1|ensembl:ENSMUSG00000026579(gene)|ensembl:ENSMUST00000086040(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0031091"(platelet alpha granule)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011707(Multicopper oxidase, type 3)|interpro:IPR024715|interpro:IPR033138|mint:O88783|reactome:R-MMU-114608|reactome:R-MMU-140875|reactome:R-MMU-204005|reactome:R-MMU-381426|reactome:R-MMU-5694530|reactome:R-MMU-8957275	-	-	comment:mint	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:uKDUvdqfAad11uLZ1qznjhrHu+410090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P19221	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8375972|intact:MINT-4137721|ensembl:ENSMUSP00000028681	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:thrb_mouse(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Cf2(gene name synonym)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_034298.1|dip:DIP-60968N|ensembl:ENSMUSG00000027249(gene)|ensembl:ENSMUST00000028681(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|interpro:IPR035972|interpro:IPR037111|interpro:IPR038178|interpro:IPR043504|mint:P19221|rcsb pdb:2OCV|rcsb pdb:2PUX|rcsb pdb:2PV9|rcsb pdb:3EDX|rcsb pdb:3HK3|rcsb pdb:3HK6|rcsb pdb:3HKI|reactome:R-MMU-140837|reactome:R-MMU-140875|reactome:R-MMU-159740|reactome:R-MMU-159763|reactome:R-MMU-159782|reactome:R-MMU-202733|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-456926|reactome:R-MMU-76009|reactome:R-MMU-977606	-	-	comment:mint|function:Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:amZ+Pl0pNliSHuykYcjQLfqb1vw10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P51660	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8328056|intact:MINT-1859569|intact:MINT-2512164|uniprotkb:Q9DBM3|ensembl:ENSMUSP00000025385	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:dhb4_mouse(display_long)|uniprotkb:Hsd17b4(gene name)|psi-mi:Hsd17b4(display_short)|uniprotkb:Edh17b4(gene name synonym)|uniprotkb:Multifunctional protein 2(gene name synonym)|uniprotkb:D-bifunctional protein(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032318.2|ensembl:ENSMUSG00000024507(gene)|ensembl:ENSMUST00000025385(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0004303"(estradiol 17-beta-dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0033989"(3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity)|go:"GO:0036111"(very long-chain fatty-acyl-CoA metabolic process)|go:"GO:0036112"(medium-chain fatty-acyl-CoA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0060009"(Sertoli cell development)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR002539(MaoC-like dehydratase)|interpro:IPR003033(Sterol-binding)|interpro:IPR020904|interpro:IPR029069|interpro:IPR036291|interpro:IPR036527|mint:P51660|reactome:R-MMU-193368|reactome:R-MMU-2046106|reactome:R-MMU-389887|reactome:R-MMU-390247|reactome:R-MMU-9033241	-	-	function:Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids|comment:mint	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:71hLYwG2pK+0vOd5eF+qYIa7J5I10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q925E7	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8322442|intact:MINT-4086270|uniprotkb:Q6ZPN5|ensembl:ENSMUSP00000040321	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:2abd_mouse(display_long)|uniprotkb:Ppp2r2d(gene name)|psi-mi:Ppp2r2d(display_short)|uniprotkb:D7Ertd753e(gene name synonym)|uniprotkb:Kiaa1541(gene name synonym)|uniprotkb:PP2A subunit B isoform delta(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-delta(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-delta(gene name synonym)|uniprotkb:PP2A subunit B isoform R2-delta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_080667.1|ensembl:ENSMUSG00000041769(gene)|ensembl:ENSMUST00000041097(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005829"(cytosol)|go:"GO:0010458"(exit from mitosis)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0051301"(cell division)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:Q925E7	-	-	function:The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment|comment:mint	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Zh/H8rSp0CYazGt4SwUz+532bJQ10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9D4F8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-7780439|ensembl:ENSMUSP00000044049|intact:UNK-5542993	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp4_mouse(display_long)|uniprotkb:Tubgcp4(gene name)|psi-mi:Tubgcp4(display_short)|uniprotkb:D2Ertd435e(gene name synonym)|uniprotkb:Gcp4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000027263(gene)|ensembl:ENSMUST00000039541(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005813"(centrosome)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0055037"(recycling endosome)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|interpro:IPR042241|mint:Q9D4F8|reactome:R-MMU-380270|reactome:R-MMU-380320|go:"GO:0005874"(microtubule)|refseq:NP_700436.1	-	-	function:Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome|comment:mint	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:uoyvScV5OQTR+AqUMMIYMhe/a/Q10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q921H8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8330006|intact:MINT-1858351|ensembl:ENSMUSP00000042351	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:thika_mouse(display_long)|uniprotkb:Acetyl-CoA C-myristoyltransferase(gene name synonym)|uniprotkb:Acaa1a(gene name)|psi-mi:Acaa1a(display_short)|uniprotkb:Acaa1(gene name synonym)|uniprotkb:Beta-ketothiolase A(gene name synonym)|uniprotkb:Acetyl-CoA acyltransferase A(gene name synonym)|uniprotkb:Peroxisomal 3-oxoacyl-CoA thiolase A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_570934.1|refseq:XP_006511986.1|ensembl:ENSMUSG00000036138(gene)|ensembl:ENSMUST00000039784(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008775"(acetate CoA-transferase activity)|go:"GO:0010124"(phenylacetate catabolic process)|go:"GO:0016401"(palmitoyl-CoA oxidase activity)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:Q921H8|reactome:R-MMU-2046106|reactome:R-MMU-390247|reactome:R-MMU-6798695|reactome:R-MMU-9033241	-	-	comment:mint	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:A7f6/enaS9RJZ+DDXxVXXa/9vTU10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q3UHD3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472278|ensembl:ENSMUSP00000082694|uniprotkb:B9EKJ2|uniprotkb:Q7TPP7|uniprotkb:Q8CHD2|uniprotkb:Q9CY74	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mtus2_mouse(display_long)|uniprotkb:Mtus2(gene name)|psi-mi:Mtus2(display_short)|uniprotkb:Cazip(gene name synonym)|uniprotkb:Kiaa0774(gene name synonym)|uniprotkb:Tip150(gene name synonym)|uniprotkb:Cardiac zipper protein(gene name synonym)|uniprotkb:Microtubule plus-end tracking protein TIP150(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000029651(gene)|ensembl:ENSMUST00000085558(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR033339|mint:Q3UHD3|refseq:NP_084196.4|refseq:XP_006504953.1	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:42tgoThcDyvR8GE7irQd8rHlKL410090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P33215	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2366213|uniprotkb:Q6NXV3|uniprotkb:Q8BN12|uniprotkb:Q8BN86|uniprotkb:Q8BQL9|uniprotkb:Q9CWK2|ensembl:ENSMUSP00000020163	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:nedd1_mouse(display_long)|uniprotkb:Nedd1(gene name)|psi-mi:Nedd1(display_short)|uniprotkb:Nedd-1(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032708.2|ensembl:ENSMUSG00000019988(gene)|ensembl:ENSMUST00000020163(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000922"(spindle pole)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0031109"(microtubule polymerization or depolymerization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045177"(apical part of cell)|go:"GO:0051301"(cell division)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P33215|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:xBFWC64fRlKEVonqdYWgcVEPK0010090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9QXL8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472305	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:ndk7_mouse(display_long)|uniprotkb:Nme7(gene name)|psi-mi:Nme7(display_short)|uniprotkb:nm23-M7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	reactome:R-MMU-380320|go:"GO:0003351"(epithelial cilium movement involved in extracellular fluid movement)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005813"(centrosome)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0060830"(ciliary receptor clustering involved in smoothened signaling pathway)|go:"GO:0060972"(left/right pattern formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|reactome:R-MMU-380270|mint:Q9QXL8|interpro:IPR034907|interpro:IPR036850|interpro:IPR011410(Nucleoside diphosphate kinase, NDK7)|interpro:IPR035525|interpro:IPR037993|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR006602(Region of unknown function DM10)	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:zkOjHmuz7jAgTi/5/MQYROLtVKg10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P01027	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-4281083|uniprotkb:Q80XP1|ensembl:ENSMUSP00000024988|uniprotkb:Q61370	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:co3_mouse(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:HSE-MSF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000024164(gene)|ensembl:ENSMUST00000024988(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008289"(lipid binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01027|rcsb pdb:6XZU|reactome:R-MMU-173736|reactome:R-MMU-174577|reactome:R-MMU-198933|reactome:R-MMU-375276|reactome:R-MMU-381426|reactome:R-MMU-418594|reactome:R-MMU-6798695|reactome:R-MMU-8957275|reactome:R-MMU-977606|refseq:NP_033908.2	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:VGFRYhKETrS9O7cyeJZyxBFgBL410090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9CQ25	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2552037|ensembl:ENSMUSP00000023351|ensembl:ENSMUSP00000113832	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mzt2_mouse(display_long)|uniprotkb:Fam128b(gene name synonym)|uniprotkb:Mozart2(gene name synonym)|uniprotkb:Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B(gene name synonym)|uniprotkb:Mzt2(gene name)|psi-mi:Mzt2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|interpro:IPR024332|ensembl:ENSMUSG00000022671(gene)|mint:Q9CQ25|reactome:R-MMU-380270|reactome:R-MMU-380320|ensembl:ENSMUST00000023351(transcript)|ensembl:ENSMUST00000117136(transcript)|refseq:NP_083630.1|refseq:XP_006522651.1	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:heL4NryOHurQ03jZtyHwM/D5Xe810090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P58252	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-773856|uniprotkb:Q544E4|ensembl:ENSMUSP00000046101	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:ef2_mouse(display_long)|uniprotkb:Eef2(gene name)|psi-mi:Eef2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_031933.1|ensembl:ENSMUSG00000034994(gene)|ensembl:ENSMUST00000047864(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006414"(translational elongation)|go:"GO:0007568"(aging)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016235"(aggresome)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051593"(response to folic acid)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031157|interpro:IPR035647|interpro:IPR041095|mint:P58252|reactome:R-MMU-156902|reactome:R-MMU-5358493|reactome:R-MMU-6798695	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:910/vo3IRjcncyPD4f43dPtS83o10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P11276	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-641955|uniprotkb:G5E8B8|uniprotkb:Q61567|uniprotkb:Q61568|uniprotkb:Q61569|uniprotkb:Q64233|uniprotkb:Q80UI4|ensembl:ENSMUSP00000054499	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:finc_mouse(display_long)|uniprotkb:Fn1(gene name)|psi-mi:Fn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_034363.1|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P11276|rcsb pdb:1MFN|rcsb pdb:2MFN|reactome:R-MMU-114608|reactome:R-MMU-1474228|reactome:R-MMU-1474244|reactome:R-MMU-1566977|reactome:R-MMU-202733|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000170|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381426|reactome:R-MMU-5674135|reactome:R-MMU-8874081|reactome:R-MMU-8957275|ensembl:ENSMUSG00000026193(gene)|ensembl:ENSMUST00000055226(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005577"(fibrinogen complex)	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:qndGPG6vmzpIIkDuO1BrVRI1oPg10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q91VN4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-776230|uniprotkb:Q3UNQ1|uniprotkb:Q9D5I5|uniprotkb:Q9DAM8|ensembl:ENSMUSP00000032172	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mic25_mouse(display_long)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 6(gene name synonym)|uniprotkb:Mic25(gene name synonym)|uniprotkb:Chchd6(gene name)|psi-mi:Chchd6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001161208.1|refseq:NP_079627.3|ensembl:ENSMUSG00000030086(gene)|ensembl:ENSMUST00000032172(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|interpro:IPR042860|mint:Q91VN4	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Op64pUsaaQVJ4d+W9vkGMMkgI8810090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8BKN5	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-11075667|uniprotkb:Q8C083|uniprotkb:Q69Z75|uniprotkb:Q8BLJ9|uniprotkb:Q3U8X5|ensembl:ENSMUSP00000032627	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp5_mouse(display_long)|uniprotkb:Tubgcp5(gene name)|psi-mi:Tubgcp5(display_short)|uniprotkb:Kiaa1899(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_666302.2|ensembl:ENSMUSG00000033790(gene)|ensembl:ENSMUST00000032627(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008017"(microtubule binding)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|interpro:IPR042241|mint:Q8BKN5|reactome:R-MMU-380270|reactome:R-MMU-380320	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:1BOIJxOyERW8OOgl7YGHj9W2PMw10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9CQR4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-299825|ensembl:ENSMUSP00000006900	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:aco13_mouse(display_long)|uniprotkb:Acot13(gene name)|psi-mi:Acot13(display_short)|uniprotkb:Hotdog-fold thioesterase superfamily member 2(gene name synonym)|uniprotkb:Palmitoyl-CoA hydrolase(gene name synonym)|uniprotkb:Them2(gene name synonym)|uniprotkb:Thioesterase superfamily member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000006717(gene)|ensembl:ENSMUST00000006900(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR003736(Phenylacetic acid degradation-related protein)|interpro:IPR006683(Thioesterase superfamily)|interpro:IPR029069|interpro:IPR039298|mint:Q9CQR4|rcsb pdb:2CY9|reactome:R-MMU-77289|refseq:NP_080066.1	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:jMok2ZPtX2ETleMlnA+90d/FVxs10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P24270	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2924912|uniprotkb:Q3TXQ6|ensembl:ENSMUSP00000028610	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:cata_mouse(display_long)|uniprotkb:Cat(gene name)|psi-mi:Cat(display_short)|uniprotkb:Cas-1(gene name synonym)|uniprotkb:Cas1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0055093"(response to hyperoxia)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0080184"(response to phenylpropanoid)|interpro:IPR002226(Catalase)|interpro:IPR010582(Catalase-related)|interpro:IPR011614(Catalase, N-terminal)|interpro:IPR018028|interpro:IPR020835|interpro:IPR024708|interpro:IPR024711|interpro:IPR040333|mint:P24270|reactome:R-MMU-3299685|reactome:R-MMU-6798695|reactome:R-MMU-9033241|go:"GO:0051781"(positive regulation of cell division)|ensembl:ENSMUSG00000027187(gene)|ensembl:ENSMUST00000028610(transcript)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0004096"(catalase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009642"(response to light intensity)|go:"GO:0009650"(UV protection)|go:"GO:0010193"(response to ozone)|go:"GO:0010288"(response to lead ion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0016209"(antioxidant activity)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019899"(enzyme binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|refseq:NP_033934.2	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Ahsw8/VMIQAUw7mWuBSFRn9g/3M10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P32020	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-309563|uniprotkb:Q9DBM7|uniprotkb:A2APS2|uniprotkb:A2APS3|ensembl:ENSMUSP00000030340	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:scp2_mouse(display_long)|uniprotkb:Scp2(gene name)|psi-mi:Scp2(display_short)|uniprotkb:Scp-2(gene name synonym)|uniprotkb:Propanoyl-CoA C-acyltransferase(gene name synonym)|uniprotkb:Sterol carrier protein X(gene name synonym)|uniprotkb:SCP-chi(gene name synonym)|uniprotkb:Acetyl-CoA C-myristoyltransferase(gene name synonym)|uniprotkb:Non-specific lipid-transfer protein(gene name synonym)|uniprotkb:SCP-2/3-oxoacyl-CoA thiolase(gene name synonym)|uniprotkb:SCP-2/thiolase(gene name synonym)|uniprotkb:Straight-chain acyl-CoA oxidase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035457.1|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006701"(progesterone biosynthetic process)|go:"GO:0007031"(peroxisome organization)|go:"GO:0007568"(aging)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008526"(phosphatidylinositol transfer activity)|go:"GO:0010893"(positive regulation of steroid biosynthetic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032385"(positive regulation of intracellular cholesterol transport)|go:"GO:0032934"(sterol binding)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033814"(propanoyl-CoA C-acyltransferase activity)|go:"GO:0036042"(long-chain fatty acyl-CoA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045940"(positive regulation of steroid metabolic process)|go:"GO:0050632"(propionyl-CoA C2-trimethyltridecanoyltransferase activity)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|go:"GO:0070538"(oleic acid binding)|go:"GO:0071071"(regulation of phospholipid biosynthetic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0120019"(phosphatidylcholine transfer activity)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1901373"(lipid hydroperoxide transport)|go:"GO:1904109"(positive regulation of cholesterol import)|go:"GO:1904121"(phosphatidylethanolamine transfer activity)|interpro:IPR003033(Sterol-binding)|interpro:IPR016039(Thiolase-like)|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|interpro:IPR036527|mint:P32020|go:"GO:0006637"(acyl-CoA metabolic process)|ensembl:ENSMUSG00000028603(gene)|ensembl:ENSMUST00000030340(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:IpeZbl/Hw0r6QueEBBV8WBaMnNM10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q62383	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1373250|uniprotkb:Q5SYM0|uniprotkb:Q6GQS3|uniprotkb:Q6ZQI0|uniprotkb:Q8BQY6|ensembl:ENSMUSP00000002121	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:spt6h_mouse(display_long)|uniprotkb:Supt6h(gene name)|psi-mi:Supt6h(display_short)|uniprotkb:Kiaa0162(gene name synonym)|uniprotkb:Supt6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_033323.2|ensembl:ENSMUSG00000002052(gene)|ensembl:ENSMUST00000002121(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003677"(DNA binding)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008380"(RNA splicing)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034728"(nucleosome organization)|go:"GO:0035327"|go:"GO:0042393"(histone binding)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0051028"(mRNA transport)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0070827"(obsolete chromatin maintenance)|interpro:IPR000980(SH2 motif)|interpro:IPR003029(S1, RNA binding)|interpro:IPR006641(Resolvase, RNase H-like fold)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR017072(Transcription elongation factor Spt6)|interpro:IPR022967|interpro:IPR023319|interpro:IPR023323|interpro:IPR028083|interpro:IPR028088|interpro:IPR028231|interpro:IPR032706|interpro:IPR035018|interpro:IPR035019|interpro:IPR035420|interpro:IPR036860|interpro:IPR037027|interpro:IPR041692|interpro:IPR042066|mint:Q62383|reactome:R-MMU-112382|reactome:R-MMU-674695|reactome:R-MMU-75955	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:h9yOnI51aroUlQNPlgQzPlOquJs10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:O70456	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1544118|uniprotkb:Q3TEZ1|ensembl:ENSMUSP00000050374	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:1433s_mouse(display_long)|uniprotkb:Sfn(gene name)|psi-mi:Sfn(display_short)|uniprotkb:Mkrn3(gene name synonym)|uniprotkb:Stratifin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_061224.2|ensembl:ENSMUSG00000047281(gene)|ensembl:ENSMUST00000057311(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003334"(keratinocyte development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010482"(regulation of epidermal cell division)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0031424"(keratinization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061436"(establishment of skin barrier)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR037435|mint:O70456|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-6804114|reactome:R-MMU-75035|reactome:R-MMU-9614399|go:"GO:0030307"(positive regulation of cell growth)	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:6B8XqFSuqdwWT6hYap/ecmwIuaY10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:E9Q8I9	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-16732044|ensembl:ENSMUSP00000084454|uniprotkb:Q4VA57|uniprotkb:Q5DTL4|uniprotkb:Q8BIW6|uniprotkb:Q8BUA0|uniprotkb:Q8CG91	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fry_mouse(display_long)|uniprotkb:Fry(gene name)|psi-mi:Fry(display_short)|uniprotkb:Kiaa4143(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000056602(gene)|ensembl:ENSMUST00000087204(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005938"(cell cortex)|go:"GO:0030427"(site of polarized growth)|go:"GO:0031175"(neuron projection development)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025481|interpro:IPR025614|interpro:IPR029473|interpro:IPR039867|mint:E9Q8I9|refseq:NP_766475.2|refseq:XP_006504993.1	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:fvduzhqkwcM9qmnWvPWAA1W8HqI10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P68510	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-444641|uniprotkb:P11576|uniprotkb:P70198|uniprotkb:Q3TGZ9|ensembl:ENSMUSP00000019109	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:1433f_mouse(display_long)|uniprotkb:Ywhah(gene name)|psi-mi:Ywhah(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035868.1|ensembl:ENSMUSG00000018965(gene)|ensembl:ENSMUST00000019109(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P68510|rcsb pdb:5YQG|go:"GO:0006886"(intracellular protein transport)|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Ew2uUYIXrZ8nnP52xMnGB6KOCqc10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8CAQ8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-776087|uniprotkb:Q66JS4|uniprotkb:Q7TNE2|uniprotkb:Q8C7V1|uniprotkb:Q8CCI0|uniprotkb:Q8CDA8|uniprotkb:Q9D9F6|ensembl:ENSMUSP00000066181	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mic60_mouse(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:Immt(gene name)|psi-mi:Immt(display_short)|uniprotkb:Mic60(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_083949.2|refseq:NP_001240617.1|refseq:NP_001240610.1|refseq:NP_001240616.1|dip:DIP-32050N|ensembl:ENSMUSG00000052337(gene)|ensembl:ENSMUST00000064062(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|mint:Q8CAQ8|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0042407"(cristae formation)|go:"GO:0043209"(myelin sheath)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:fW23bvuLqjLn5wIOu6ycDsh7O1k10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P68254	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-400675|uniprotkb:P35216|uniprotkb:Q3TW69|uniprotkb:Q3UJN5|uniprotkb:Q5SP76|uniprotkb:Q5U423|uniprotkb:Q66JR6|ensembl:ENSMUSP00000100067|ensembl:ENSMUSP00000123605	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:1433t_mouse(display_long)|uniprotkb:Ywhaq(gene name)|psi-mi:Ywhaq(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035869.1|ensembl:ENSMUSG00000076432(gene)|ensembl:ENSMUST00000103002(transcript)|ensembl:ENSMUST00000135088(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P68254|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9614399	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:l8bki6QJJEH5S5NIwQdm/MAYcc010090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P08113	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-772439|uniprotkb:P11427|ensembl:ENSMUSP00000020238	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:enpl_mouse(display_long)|uniprotkb:Heat shock protein 90 kDa beta member 1(gene name synonym)|uniprotkb:94 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Grp94(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 99(gene name synonym)|uniprotkb:Polymorphic tumor rejection antigen 1(gene name synonym)|uniprotkb:Tumor rejection antigen gp96(gene name synonym)|uniprotkb:Hsp90b1(gene name)|psi-mi:Hsp90b1(display_short)|uniprotkb:Tra-1(gene name synonym)|uniprotkb:Tra1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035761.1|dip:DIP-32352N|ensembl:ENSMUSG00000020048(gene)|ensembl:ENSMUST00000020238(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031247"(actin rod assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0042470"(melanosome)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071318"(cellular response to ATP)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08113|reactome:R-MMU-1679131|reactome:R-MMU-3000480|reactome:R-MMU-381426|reactome:R-MMU-6785807|reactome:R-MMU-8957275	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:6hS1V+GSgQiDvTYBpzbfdL5FDcE10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P62962	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-647096|uniprotkb:P10924|ensembl:ENSMUSP00000018437	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:prof1_mouse(display_long)|uniprotkb:Profilin I(gene name synonym)|uniprotkb:Pfn1(gene name)|psi-mi:Pfn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035202.1|dip:DIP-38075N|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050821"(protein stabilization)|go:"GO:0051054"(positive regulation of DNA metabolic process)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060074"(synapse maturation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR005454(Profilin, Mammalian)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR029892|interpro:IPR036140|mint:P62962|reactome:R-MMU-376176|reactome:R-MMU-4086400|reactome:R-MMU-5663220|ensembl:ENSMUSG00000018293(gene)|ensembl:ENSMUST00000018437(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:nzOTw5XdywGrh+fA9AInGIexyGk10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q5SRY7	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-11073522|uniprotkb:Q923H0|uniprotkb:Q3TLZ8|uniprotkb:Q3TGM9|uniprotkb:Q8K022|uniprotkb:Q8BY90|ensembl:ENSMUSP00000090893	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fbw1b_mouse(display_long)|uniprotkb:Fbxw11(gene name)|psi-mi:Fbxw11(display_short)|uniprotkb:Btrcp2(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:Fbw1b(gene name synonym)|uniprotkb:Fbxw1b(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001258276.1|refseq:NP_001258277.1|refseq:NP_001258278.1|refseq:NP_598776.1|ensembl:ENSMUSG00000020271(gene)|ensembl:ENSMUST00000093205(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048511"(rhythmic process)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q5SRY7|reactome:R-MMU-1169091|reactome:R-MMU-202424|reactome:R-MMU-2565942|reactome:R-MMU-2871837|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5676590|reactome:R-MMU-5684264|reactome:R-MMU-8951664|reactome:R-MMU-983168|dip:DIP-59921N	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:ahDg2ntR1uE9TEaFa8xgmsH3Ijg10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q921I1	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-761948|uniprotkb:O35421|uniprotkb:Q3UBW7|uniprotkb:Q58E69|uniprotkb:Q61803|uniprotkb:Q62357|uniprotkb:Q62358|uniprotkb:Q62359|uniprotkb:Q63915|uniprotkb:Q64515|uniprotkb:Q8VII5|uniprotkb:Q922C0|ensembl:ENSMUSP00000108264|ensembl:ENSMUSP00000035158	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:trfe_mouse(display_long)|uniprotkb:Siderophilin(gene name synonym)|uniprotkb:Beta-1 metal-binding globulin(gene name synonym)|uniprotkb:Tf(gene name)|psi-mi:Tf(display_short)|uniprotkb:Trf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_598738.1|ensembl:ENSMUSG00000032554(gene)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0097433"(dense body)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR001156(Peptidase S60, transferrin lactoferrin)|interpro:IPR016357(Transferrin)|interpro:IPR018195|interpro:IPR030685|mint:Q921I1|reactome:R-MMU-114608|reactome:R-MMU-381426|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8957275|reactome:R-MMU-917937|reactome:R-MMU-917977|ensembl:ENSMUST00000035158(transcript)|ensembl:ENSMUST00000112645(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007015"(actin filament organization)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030120"(vesicle coat)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0031982"(vesicle)|go:"GO:0034756"(regulation of iron ion transport)|go:"GO:0034986"(iron chaperone activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0045178"(basal part of cell)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0055037"(recycling endosome)|go:"GO:0009986"(cell surface)	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:V7U4fb+43G8NBKnZT/9PR+9HiQk10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P35441	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-6171593	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tsp1_mouse(display_long)|uniprotkb:Thbs1(gene name)|psi-mi:Thbs1(display_short)|uniprotkb:Tsp1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0043236"(laminin binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|reactome:R-MMU-114608|reactome:R-MMU-186797|reactome:R-MMU-216083|reactome:R-MMU-5173214|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016477"(cell migration)|interpro:IPR001881(EGF-like calcium-binding)|mint:P35441|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR017897|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:0j9TPpvxNW9TNMFkFCNo+9wD3fA10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P11087	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1634830|uniprotkb:Q53WT0|uniprotkb:Q60635|uniprotkb:Q61367|uniprotkb:Q61427|uniprotkb:Q63919|uniprotkb:Q6PCL3|uniprotkb:Q810J9|ensembl:ENSMUSP00000001547	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:co1a1_mouse(display_long)|uniprotkb:Col1a1(gene name)|psi-mi:Col1a1(display_short)|uniprotkb:Cola1(gene name synonym)|uniprotkb:Alpha-1 type I collagen(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_031768.2|ensembl:ENSMUSG00000001506(gene)|ensembl:ENSMUST00000001547(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0001958"(endochondral ossification)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005584"(collagen type I trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0015031"(protein transport)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032355"(response to estradiol)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034505"(tooth mineralization)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043588"(skin development)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044691"(tooth eruption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0051591"(response to cAMP)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071306"(cellular response to vitamin E)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902618"(cellular response to fluoride)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR008160(Collagen triple helix repeat)|mint:P11087|reactome:R-MMU-114604|reactome:R-MMU-1442490|reactome:R-MMU-1474244|reactome:R-MMU-1650814|reactome:R-MMU-198933|reactome:R-MMU-2022090|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-2214320|reactome:R-MMU-2243919|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-430116|reactome:R-MMU-75892|reactome:R-MMU-76009|reactome:R-MMU-8874081|reactome:R-MMU-8948216|go:"GO:0002020"(protease binding)	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:mZrc8e1VDJc4u6y4zXOj0glFj9410090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q6GQT1	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26473702|ensembl:ENSMUSP00000032203|uniprotkb:E9QMQ7|uniprotkb:Q811S0	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:a2mg_mouse(display_long)|uniprotkb:A2m(gene name)|psi-mi:A2m(display_short)|uniprotkb:A2mp(gene name synonym)|uniprotkb:Alpha-2-macroglobulin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000030111(gene)|ensembl:ENSMUST00000032203(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007565"(female pregnancy)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048863"(stem cell differentiation)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR019742|interpro:IPR036595|interpro:IPR040839|interpro:IPR041555|interpro:IPR041813|mint:Q6GQT1|reactome:R-MMU-114608|reactome:R-MMU-140837|reactome:R-MMU-1474228|reactome:R-MMU-8963896|refseq:NP_783327.2	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:uf5Mk7VLjnfs0IkZp4CoUuuAkb010090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9R0L6	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-4284371|uniprotkb:O70287|uniprotkb:Q3URH6|uniprotkb:Q7TMS7|uniprotkb:Q8C9V2|uniprotkb:Q91Y27|uniprotkb:Q91Y28|uniprotkb:Q91Y51|uniprotkb:Q9CRK8|uniprotkb:Q923L0|uniprotkb:Q9CT57|uniprotkb:E9QLK2|ensembl:ENSMUSP00000039709	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:pcm1_mouse(display_long)|uniprotkb:Pcm1(gene name)|psi-mi:Pcm1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_076151.2|refseq:XP_006509361.1|ensembl:ENSMUSG00000031592(gene)|ensembl:ENSMUST00000045218(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q9R0L6|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-5620912|reactome:R-MMU-8854518|reactome:R-MMU-380320	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:OT+ZOQY5pqQojMcLCWMIY+6zdl410090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9WTX5	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1202363|uniprotkb:Q8C5H6|ensembl:ENSMUSP00000038744|ensembl:ENSMUSP00000104700	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:skp1_mouse(display_long)|uniprotkb:Skp1(gene name)|psi-mi:Skp1(display_short)|uniprotkb:Skp1a(gene name synonym)|uniprotkb:S-phase kinase-associated protein 1A(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:p19A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035673.3|refseq:XP_006532849.1|go:"GO:0019904"(protein domain specific binding)|ensembl:ENSMUSG00000036309(gene)|ensembl:ENSMUST00000037324(transcript)|ensembl:ENSMUST00000109072(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:Q9WTX5|reactome:R-MMU-1169091|reactome:R-MMU-1170546|reactome:R-MMU-187577|reactome:R-MMU-195253|reactome:R-MMU-202424|reactome:R-MMU-2565942|reactome:R-MMU-2871837|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5676590|reactome:R-MMU-5684264|reactome:R-MMU-68949|reactome:R-MMU-69231|reactome:R-MMU-8854050|reactome:R-MMU-8939902|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-917937|reactome:R-MMU-9708530|reactome:R-MMU-983168|dip:DIP-38596N	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:qGk720KMKAbBPguy2tmUOZsLxRQ10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P62259	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-356480|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSMUSP00000070993	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:1433e_mouse(display_long)|uniprotkb:Ywhae(gene name)|psi-mi:Ywhae(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000020849(gene)|ensembl:ENSMUST00000067664(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0006605"(protein targeting)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|refseq:NP_033562.3|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62259|reactome:R-MMU-111447|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-2565942|reactome:R-MMU-3371453|reactome:R-MMU-3371511|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-8876198	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q68FF6	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-645933|ensembl:ENSMUSP00000037210	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:git1_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 1(gene name synonym)|uniprotkb:GRK-interacting protein 1(gene name synonym)|uniprotkb:Git1(gene name)|psi-mi:Git1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001004144.1|ensembl:ENSMUSG00000011877(gene)|ensembl:ENSMUST00000037285(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032013"(negative regulation of ARF protein signal transduction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048666"(neuron development)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061743"(motor learning)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR032352|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q68FF6|rcsb pdb:6JMU|reactome:R-MMU-3928664|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:3br9Xz6GZQV409u3u7CZDfqKMIM10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9ES28	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-642580|uniprotkb:O08757|uniprotkb:Q3UTS5|uniprotkb:Q6XPA5|uniprotkb:Q6ZQI5|uniprotkb:Q8C750|uniprotkb:Q91ZZ6|uniprotkb:Q9ES27	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:arhg7_mouse(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:p85SPR(gene name synonym)|uniprotkb:Arhgef7(gene name)|psi-mi:Arhgef7(display_short)|uniprotkb:Pak3bp(gene name synonym)|uniprotkb:Kiaa0142(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001106989.1|refseq:NP_001106990.1|refseq:NP_059098.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|refseq:XP_006508906.2|refseq:XP_006508907.2|interpro:IPR032409|refseq:XP_006508904.2|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013424|go:"GO:0000322"(storage vacuole)|go:"GO:0001726"(ruffle)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030426"(growth cone)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099140"(presynaptic actin cytoskeleton organization)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|rcsb pdb:2ESW|rcsb pdb:6JMT|reactome:R-MMU-182971|reactome:R-MMU-193648|reactome:R-MMU-3928664|mint:Q9ES28|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:+Bie+UoaAI9/ldibUxAjNYc3sYs10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P63330	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-397144|uniprotkb:O88591|uniprotkb:P13353|uniprotkb:Q5SNY5|ensembl:ENSMUSP00000020608	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:pp2aa_mouse(display_long)|uniprotkb:Ppp2ca(gene name)|psi-mi:Ppp2ca(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_062284.1|ensembl:ENSMUSG00000020349(gene)|ensembl:ENSMUST00000020608(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007498"(mesoderm development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1990405"(protein antigen binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:P63330|reactome:R-MMU-113501|reactome:R-MMU-1295596|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2995383|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-4641262|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6804757|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-9648025|reactome:R-MMU-975957	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:gpR5Fal3vi6O6cteeGwW72EuctY10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q6P1F6	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-997427|ensembl:ENSMUSP00000086640	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:2aba_mouse(display_long)|uniprotkb:PP2A subunit B isoform alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-alpha(gene name synonym)|uniprotkb:Ppp2r2a(gene name)|psi-mi:Ppp2r2a(display_short)|uniprotkb:PP2A subunit B isoform R2-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001192117.1|refseq:NP_082308.1|ensembl:ENSMUSG00000022052(gene)|ensembl:ENSMUST00000089230(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0043278"(response to morphine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:Q6P1F6|reactome:R-MMU-2995383|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-975957	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:evS6klM2alZXtMthVsshKkrNgiA10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8VCK3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-17170916|ensembl:ENSMUSP00000045901	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tbg2_mouse(display_long)|uniprotkb:Gamma-2-tubulin(gene name synonym)|uniprotkb:Tubg2(gene name)|psi-mi:Tubg2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000045007(gene)|ensembl:ENSMUST00000043654(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|interpro:IPR000217(Tubulin)|interpro:IPR002454(Gamma tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q8VCK3|reactome:R-MMU-380270|reactome:R-MMU-380320|refseq:NP_598789.1	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:ebQHblMVkTKA8wnY1ae2fdPzx8I10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9JL26	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-772250|uniprotkb:Q6KAN4|uniprotkb:Q9Z2V7|ensembl:ENSMUSP00000046296	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fmnl1_mouse(display_long)|uniprotkb:Formin-related protein(gene name synonym)|uniprotkb:Fmnl1(gene name)|psi-mi:Fmnl1(display_short)|uniprotkb:Frl(gene name synonym)|uniprotkb:Frl1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001071166.1|refseq:NP_062653.2|ensembl:ENSMUSG00000055805(gene)|ensembl:ENSMUST00000042286(transcript)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009987"(cellular process)|go:"GO:0016477"(cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027657|interpro:IPR042201|interpro:IPR043592|mint:Q9JL26|reactome:R-MMU-5663220|reactome:R-MMU-9013148|reactome:R-MMU-9013149	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:TStYWzz5LdFY4BeOWifTZyl6uTw10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8C0D4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472248|ensembl:ENSMUSP00000138585|uniprotkb:Q8BVP8	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:rhg12_mouse(display_long)|uniprotkb:Arhgap12(gene name)|psi-mi:Arhgap12(display_short)|uniprotkb:Rho-type GTPase-activating protein 12(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000041225(gene)|ensembl:ENSMUST00000182559(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035491|interpro:IPR036020|interpro:IPR036028|mint:Q8C0D4|rcsb pdb:6GVC|reactome:R-MMU-9013149|reactome:R-MMU-9013405|reactome:R-MMU-9013424|reactome:R-MMU-9035034|refseq:NP_001034781.1|refseq:NP_083553.2	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:daP4oZJo5g2WAFHv8quvfttZ0H810090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q76MZ3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-400413|ensembl:ENSMUSP00000007708	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:2aaa_mouse(display_long)|uniprotkb:Ppp2r1a(gene name)|psi-mi:Ppp2r1a(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_058587.1|go:"GO:0051306"(mitotic sister chromatid separation)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903538"(regulation of meiotic cell cycle process involved in oocyte maturation)|go:"GO:1990405"(protein antigen binding)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:Q76MZ3|rcsb pdb:2IAE|rcsb pdb:2PF4|rcsb pdb:3FGA|rcsb pdb:6EF4|reactome:R-MMU-113501|reactome:R-MMU-1295596|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-2995383|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-4641262|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6804757|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-8854518|reactome:R-MMU-9648025|reactome:R-MMU-975957|ensembl:ENSMUSG00000007564(gene)|ensembl:ENSMUST00000007708(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030425"(dendrite)|go:"GO:0045202"(synapse)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051232"(meiotic spindle elongation)|dip:DIP-29429N	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:0tnO11U1SNOOT46j23f7dim8O8k10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:G5E8P0	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2554025|ensembl:ENSMUSP00000104977|intact:EBI-11600212|uniprotkb:Q6PFC6|uniprotkb:Q6ZPK3|uniprotkb:Q8BWI2	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp6_mouse(display_long)|uniprotkb:Tubgcp6(gene name)|psi-mi:Tubgcp6(display_short)|uniprotkb:Kiaa1669(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001156791.1|ensembl:ENSMUSG00000051786(gene)|ensembl:ENSMUST00000109353(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR042241|mint:G5E8P0|reactome:R-MMU-380270|reactome:R-MMU-380320|interpro:IPR041470	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:o8N6a4n0HmcfpjPF0YcWNZVH39c10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P58854	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2551135|ensembl:ENSMUSP00000000776|uniprotkb:Q6PDQ9	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp3_mouse(display_long)|uniprotkb:Gcp3(gene name synonym)|uniprotkb:Tubgcp3(gene name)|psi-mi:Tubgcp3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	reactome:R-MMU-380320|ensembl:ENSMUSG00000000759(gene)|ensembl:ENSMUST00000000776(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005827"(polar microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:P58854|reactome:R-MMU-380270|refseq:NP_932148.1	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:qyzJzan6HpBMaAAOyhPM+94ecQA10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q3UHB8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-16731180|ensembl:ENSMUSP00000072982|uniprotkb:Q6NXJ5	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:cc177_mouse(display_long)|uniprotkb:Ccdc177(gene name)|psi-mi:Ccdc177(display_short)|uniprotkb:Gm1568(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000062961(gene)|ensembl:ENSMUST00000073251(transcript)|interpro:IPR029090|mint:Q3UHB8|refseq:NP_001008423.2	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:objGQkpHL5Pr4FZHhKDHYGjAVUU10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P83887	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2553410|ensembl:ENSMUSP00000048036|uniprotkb:Q9Z310	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tbg1_mouse(display_long)|uniprotkb:Tubg1(gene name)|psi-mi:Tubg1(display_short)|uniprotkb:Tubg(gene name synonym)|uniprotkb:Gamma-1-tubulin(gene name synonym)|uniprotkb:Gamma-tubulin complex component 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000035198(gene)|ensembl:ENSMUST00000043680(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005827"(polar microtubule)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005929"(cilium)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0055037"(recycling endosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000217(Tubulin)|interpro:IPR002454(Gamma tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|go:"GO:0005525"(GTP binding)|interpro:IPR037103|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518|mint:P83887|refseq:NP_598785.1	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:vuOzSmoj6s4iR1pV9zNfwxYjue810090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9WV30	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472334|ensembl:ENSMUSP00000116094|uniprotkb:E9Q0P3|uniprotkb:E9Q6U2|uniprotkb:G5E8N9|uniprotkb:Q91WY0|uniprotkb:Q9JLA1	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:nfat5_mouse(display_long)|uniprotkb:Nfat5(gene name)|psi-mi:Nfat5(display_short)|uniprotkb:Rel domain-containing transcription factor NFAT5(gene name synonym)|uniprotkb:T-cell transcription factor NFAT5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000003847(gene)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0010628"(positive regulation of gene expression)|ensembl:ENSMUST00000125721(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|interpro:IPR011539(Rel homology)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0005634"(nucleus)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0005654"(nucleoplasm)|interpro:IPR015646(Nuclear factor of activated T-cells 5)|interpro:IPR032397|interpro:IPR037059|mint:Q9WV30|refseq:NP_001273189.1|refseq:NP_061293.2|refseq:NP_598718.2|refseq:XP_006531255.1|refseq:XP_017168393.1	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Yf1n8cmeTkVMCL5aw+LQZwrAIcM10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8BUR9	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2553237|ensembl:ENSMUSP00000037557	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mzt1_mouse(display_long)|uniprotkb:Mzt1(gene name)|psi-mi:Mzt1(display_short)|uniprotkb:Mozart1(gene name synonym)|uniprotkb:Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUST00000042662(transcript)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0033566"(gamma-tubulin complex localization)|go:"GO:0051415"(microtubule nucleation by interphase microtubule organizing center)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR022214|mint:Q8BUR9|reactome:R-MMU-380270|reactome:R-MMU-380320|ensembl:ENSMUSG00000033186(gene)|refseq:NP_780454.1	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:a686Bpxk37Kl0gKKTz14f6sq6s410090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q921G8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2552389|ensembl:ENSMUSP00000026547|uniprotkb:G5E859	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp2_mouse(display_long)|uniprotkb:Gcp2(gene name synonym)|uniprotkb:Tubgcp2(gene name)|psi-mi:Tubgcp2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001272936.1|ensembl:ENSMUSG00000025474(gene)|ensembl:ENSMUST00000026547(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0001764"(neuron migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007420"(brain development)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:Q921G8|reactome:R-MMU-380270|reactome:R-MMU-380320|go:"GO:0000923"(equatorial microtubule organizing center)|refseq:NP_598516.2	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:rWPzsdt3ECnxr+ksi4MaH7okQ+M10090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P54071	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-773401|uniprotkb:Q8C2R9|uniprotkb:Q9EQK1|ensembl:ENSMUSP00000103007	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:idhp_mouse(display_long)|uniprotkb:Oxalosuccinate decarboxylase(gene name synonym)|uniprotkb:"NADP(+)-specific ICDH"(gene name synonym)|uniprotkb:IDP(gene name synonym)|uniprotkb:ICD-M(gene name synonym)|uniprotkb:Idh2(gene name)|psi-mi:Idh2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473872|imex:IM-28526-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_766599.2|ensembl:ENSMUSG00000030541(gene)|ensembl:ENSMUST00000107384(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004448"(isocitrate dehydrogenase activity)|go:"GO:0004450"("isocitrate dehydrogenase (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0006741"(NADP biosynthetic process)|go:"GO:0051287"(NAD binding)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:1903976"(negative regulation of glial cell migration)|go:"GO:1904465"(negative regulation of matrix metallopeptidase secretion)|interpro:IPR004790(Isocitrate dehydrogenase NADP-dependent, eukaryotic)|interpro:IPR019818|interpro:IPR024084|mint:P54071|rcsb pdb:5H3E|rcsb pdb:5H3F|reactome:R-MMU-2151201|reactome:R-MMU-71403	-	-	-	figure legend:ST5|comment:"Q20 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:CkBZHIePaNGTtcgyqEf03oczVM010090	rigid:8XAVK/6g5VHY/zAjLyWnaUxgpKs	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9R049	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-3648125|uniprotkb:Q8K008|uniprotkb:Q99LH5	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:amfr_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase AMFR(gene name synonym)|uniprotkb:Amfr(gene name)|psi-mi:Amfr(display_short)|uniprotkb:Autocrine motility factor receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	mint:Q9R049|refseq:NP_035917.2|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0009987"(cellular process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:2000638"(regulation of SREBP signaling pathway)|reactome:R-MMU-532668|interpro:IPR040675	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:WllN35rkcf63zUF7TI4pQwTYfOI10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:O35490	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8362567|uniprotkb:Q3UEM1|uniprotkb:Q3UL72|intact:MINT-1870182|uniprotkb:Q561N0|ensembl:ENSMUSP00000096912|ensembl:ENSMUSP00000135956	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:bhmt1_mouse(display_long)|uniprotkb:Bhmt(gene name)|psi-mi:Bhmt(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_057877.1|ensembl:ENSMUSG00000069324(gene)|ensembl:ENSMUSG00000074768(gene)|ensembl:ENSMUST00000091776(transcript)|ensembl:ENSMUST00000099309(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0006577"(amino-acid betaine metabolic process)|go:"GO:0006579"(amino-acid betaine catabolic process)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047150"(betaine-homocysteine S-methyltransferase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071267"(L-methionine salvage)|interpro:IPR003726(Homocysteine S-methyltransferase)|interpro:IPR017226(Betaine--homocysteine S-methyltransferase, BHMT)|interpro:IPR036589|mint:O35490|reactome:R-MMU-1614635|reactome:R-MMU-6798163	-	-	comment:mint|function:Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:llOjFBtpVqQ0VykdivCaaJKrwl810090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q2TPA8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8346446|uniprotkb:Q3ULY5|uniprotkb:Q3UVZ3|intact:MINT-1860458|uniprotkb:Q99LV2|uniprotkb:Q8C3H3|ensembl:ENSMUSP00000030078	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:hsdl2_mouse(display_long)|uniprotkb:Hsdl2(gene name)|psi-mi:Hsdl2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_077217.2|ensembl:ENSMUSG00000028383(gene)|ensembl:ENSMUST00000030078(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR003033(Sterol-binding)|interpro:IPR036291|interpro:IPR036527|mint:Q2TPA8	-	-	comment:mint	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:EuUAecUkC7gRKu9bZnI12W9iz6w10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q61704	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8320806|intact:MINT-4099088|uniprotkb:E9QME9|uniprotkb:Q91WG9|ensembl:ENSMUSP00000006697	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:itih3_mouse(display_long)|uniprotkb:Itih3(gene name)|psi-mi:Itih3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032433.2|ensembl:ENSMUSG00000006522(gene)|ensembl:ENSMUST00000006697(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010600(Inter-alpha-trypsin inhibitor heavy chain, C-terminal)|interpro:IPR013694(Vault protein inter-alpha-trypsin)|interpro:IPR036465|mint:Q61704|reactome:R-MMU-114608	-	-	function:May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes|comment:mint	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Pdi9OY15tRMIbi72dbN6I0+9U1A10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P19221	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8375972|intact:MINT-4137721|ensembl:ENSMUSP00000028681	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:thrb_mouse(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Cf2(gene name synonym)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_034298.1|dip:DIP-60968N|ensembl:ENSMUSG00000027249(gene)|ensembl:ENSMUST00000028681(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|interpro:IPR035972|interpro:IPR037111|interpro:IPR038178|interpro:IPR043504|mint:P19221|rcsb pdb:2OCV|rcsb pdb:2PUX|rcsb pdb:2PV9|rcsb pdb:3EDX|rcsb pdb:3HK3|rcsb pdb:3HK6|rcsb pdb:3HKI|reactome:R-MMU-140837|reactome:R-MMU-140875|reactome:R-MMU-159740|reactome:R-MMU-159763|reactome:R-MMU-159782|reactome:R-MMU-202733|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-456926|reactome:R-MMU-76009|reactome:R-MMU-977606	-	-	comment:mint|function:Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:amZ+Pl0pNliSHuykYcjQLfqb1vw10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P04186	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8346300|intact:MINT-1865229|ensembl:ENSMUSP00000119977	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:cfab_mouse(display_long)|uniprotkb:Cfb(gene name)|psi-mi:Cfb(display_short)|uniprotkb:Bf(gene name synonym)|uniprotkb:H2-Bf(gene name synonym)|uniprotkb:C3/C5 convertase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000090231(gene)|ensembl:ENSMUST00000128767(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0097066"(response to thyroid hormone)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011360(Complement B/C2)|interpro:IPR018114|interpro:IPR028341|interpro:IPR033116|interpro:IPR035976|interpro:IPR036465|mint:P04186|reactome:R-MMU-173736|reactome:R-MMU-174577|reactome:R-MMU-977606	-	-	comment:mint|function:"Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase"	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:ZIuU2m3OfhhdoW+STWEfOv2i9QM10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q925E7	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8322442|intact:MINT-4086270|uniprotkb:Q6ZPN5|ensembl:ENSMUSP00000040321	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:2abd_mouse(display_long)|uniprotkb:Ppp2r2d(gene name)|psi-mi:Ppp2r2d(display_short)|uniprotkb:D7Ertd753e(gene name synonym)|uniprotkb:Kiaa1541(gene name synonym)|uniprotkb:PP2A subunit B isoform delta(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-delta(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-delta(gene name synonym)|uniprotkb:PP2A subunit B isoform R2-delta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_080667.1|ensembl:ENSMUSG00000041769(gene)|ensembl:ENSMUST00000041097(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005829"(cytosol)|go:"GO:0010458"(exit from mitosis)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0051301"(cell division)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:Q925E7	-	-	function:The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment|comment:mint	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Zh/H8rSp0CYazGt4SwUz+532bJQ10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q921H8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8330006|intact:MINT-1858351|ensembl:ENSMUSP00000042351	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:thika_mouse(display_long)|uniprotkb:Acetyl-CoA C-myristoyltransferase(gene name synonym)|uniprotkb:Acaa1a(gene name)|psi-mi:Acaa1a(display_short)|uniprotkb:Acaa1(gene name synonym)|uniprotkb:Beta-ketothiolase A(gene name synonym)|uniprotkb:Acetyl-CoA acyltransferase A(gene name synonym)|uniprotkb:Peroxisomal 3-oxoacyl-CoA thiolase A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_570934.1|refseq:XP_006511986.1|ensembl:ENSMUSG00000036138(gene)|ensembl:ENSMUST00000039784(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008775"(acetate CoA-transferase activity)|go:"GO:0010124"(phenylacetate catabolic process)|go:"GO:0016401"(palmitoyl-CoA oxidase activity)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:Q921H8|reactome:R-MMU-2046106|reactome:R-MMU-390247|reactome:R-MMU-6798695|reactome:R-MMU-9033241	-	-	comment:mint	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:A7f6/enaS9RJZ+DDXxVXXa/9vTU10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9D4F8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-7780439|ensembl:ENSMUSP00000044049|intact:UNK-5542993	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp4_mouse(display_long)|uniprotkb:Tubgcp4(gene name)|psi-mi:Tubgcp4(display_short)|uniprotkb:D2Ertd435e(gene name synonym)|uniprotkb:Gcp4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000027263(gene)|ensembl:ENSMUST00000039541(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005813"(centrosome)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0055037"(recycling endosome)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|interpro:IPR042241|mint:Q9D4F8|reactome:R-MMU-380270|reactome:R-MMU-380320|go:"GO:0005874"(microtubule)|refseq:NP_700436.1	-	-	function:Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome|comment:mint	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:uoyvScV5OQTR+AqUMMIYMhe/a/Q10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8R4H2	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8046267|intact:MINT-1774761|uniprotkb:E9QPW9|uniprotkb:Q80U18|ensembl:ENSMUSP00000072547	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:arhgc_mouse(display_long)|uniprotkb:Arhgef12(gene name)|psi-mi:Arhgef12(display_short)|uniprotkb:Kiaa0382(gene name synonym)|uniprotkb:Larg(gene name synonym)|uniprotkb:Leukemia-associated RhoGEF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:XP_006510649.1|ensembl:ENSMUSG00000059495(gene)|ensembl:ENSMUST00000072767(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037801|interpro:IPR037884|interpro:IPR041020|mint:Q8R4H2|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148	-	-	comment:mint|function:"May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13"	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:5ZclDYjaUBilqiB548/6M5KlhVg10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P51660	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8328056|intact:MINT-1859569|intact:MINT-2512164|uniprotkb:Q9DBM3|ensembl:ENSMUSP00000025385	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:dhb4_mouse(display_long)|uniprotkb:Hsd17b4(gene name)|psi-mi:Hsd17b4(display_short)|uniprotkb:Edh17b4(gene name synonym)|uniprotkb:Multifunctional protein 2(gene name synonym)|uniprotkb:D-bifunctional protein(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032318.2|ensembl:ENSMUSG00000024507(gene)|ensembl:ENSMUST00000025385(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0004303"(estradiol 17-beta-dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0033989"(3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity)|go:"GO:0036111"(very long-chain fatty-acyl-CoA metabolic process)|go:"GO:0036112"(medium-chain fatty-acyl-CoA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0060009"(Sertoli cell development)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR002539(MaoC-like dehydratase)|interpro:IPR003033(Sterol-binding)|interpro:IPR020904|interpro:IPR029069|interpro:IPR036291|interpro:IPR036527|mint:P51660|reactome:R-MMU-193368|reactome:R-MMU-2046106|reactome:R-MMU-389887|reactome:R-MMU-390247|reactome:R-MMU-9033241	-	-	function:Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids|comment:mint	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:71hLYwG2pK+0vOd5eF+qYIa7J5I10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P06151	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-444940|ensembl:ENSMUSP00000036386|ensembl:ENSMUSP00000103267	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:ldha_mouse(display_long)|uniprotkb:LDH muscle subunit(gene name synonym)|uniprotkb:Ldha(gene name)|psi-mi:Ldha(display_short)|uniprotkb:Ldh-1(gene name synonym)|uniprotkb:Ldh1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_034829.1|ensembl:ENSMUSG00000063229(gene)|ensembl:ENSMUST00000005051(transcript)|ensembl:ENSMUST00000048209(transcript)|go:"GO:0004457"(lactate dehydrogenase activity)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019244"(lactate biosynthetic process from pyruvate)|go:"GO:0019661"(glucose catabolic process to lactate via pyruvate)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0042802"(identical protein binding)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P06151|reactome:R-MMU-70268	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:IErFuOIWq53/XyIxWgUyVi76VnM10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P10493	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1032117|uniprotkb:Q8BQI3|uniprotkb:Q8C3U8|uniprotkb:Q8C9P6|uniprotkb:Q3TKX9|ensembl:ENSMUSP00000005532	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:nid1_mouse(display_long)|uniprotkb:Nid1(gene name)|psi-mi:Nid1(display_short)|uniprotkb:Ent(gene name synonym)|uniprotkb:Entactin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035047.2|interpro:IPR026823|interpro:IPR036857|mint:P10493|rcsb pdb:1GL4|rcsb pdb:1H4U|rcsb pdb:1NPE|reactome:R-MMU-1474228|reactome:R-MMU-3000157|ensembl:ENSMUSG00000005397(gene)|ensembl:ENSMUST00000005532(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032836"(glomerular basement membrane development)|go:"GO:0043236"(laminin binding)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071944"(cell periphery)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003886(Nidogen, extracellular region)|interpro:IPR006605(G2 nidogen and fibulin G2F)|interpro:IPR009017(Green fluorescent protein-like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR024731	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:3dnqHnqAO3PlU6v5pchyqrF4UBg10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P62962	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-647096|uniprotkb:P10924|ensembl:ENSMUSP00000018437	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:prof1_mouse(display_long)|uniprotkb:Profilin I(gene name synonym)|uniprotkb:Pfn1(gene name)|psi-mi:Pfn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035202.1|dip:DIP-38075N|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050821"(protein stabilization)|go:"GO:0051054"(positive regulation of DNA metabolic process)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060074"(synapse maturation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR005454(Profilin, Mammalian)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR029892|interpro:IPR036140|mint:P62962|reactome:R-MMU-376176|reactome:R-MMU-4086400|reactome:R-MMU-5663220|ensembl:ENSMUSG00000018293(gene)|ensembl:ENSMUST00000018437(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:nzOTw5XdywGrh+fA9AInGIexyGk10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P32020	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-309563|uniprotkb:Q9DBM7|uniprotkb:A2APS2|uniprotkb:A2APS3|ensembl:ENSMUSP00000030340	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:scp2_mouse(display_long)|uniprotkb:Scp2(gene name)|psi-mi:Scp2(display_short)|uniprotkb:Scp-2(gene name synonym)|uniprotkb:Propanoyl-CoA C-acyltransferase(gene name synonym)|uniprotkb:Sterol carrier protein X(gene name synonym)|uniprotkb:SCP-chi(gene name synonym)|uniprotkb:Acetyl-CoA C-myristoyltransferase(gene name synonym)|uniprotkb:Non-specific lipid-transfer protein(gene name synonym)|uniprotkb:SCP-2/3-oxoacyl-CoA thiolase(gene name synonym)|uniprotkb:SCP-2/thiolase(gene name synonym)|uniprotkb:Straight-chain acyl-CoA oxidase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035457.1|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006701"(progesterone biosynthetic process)|go:"GO:0007031"(peroxisome organization)|go:"GO:0007568"(aging)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008526"(phosphatidylinositol transfer activity)|go:"GO:0010893"(positive regulation of steroid biosynthetic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032385"(positive regulation of intracellular cholesterol transport)|go:"GO:0032934"(sterol binding)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033814"(propanoyl-CoA C-acyltransferase activity)|go:"GO:0036042"(long-chain fatty acyl-CoA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045940"(positive regulation of steroid metabolic process)|go:"GO:0050632"(propionyl-CoA C2-trimethyltridecanoyltransferase activity)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|go:"GO:0070538"(oleic acid binding)|go:"GO:0071071"(regulation of phospholipid biosynthetic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0120019"(phosphatidylcholine transfer activity)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1901373"(lipid hydroperoxide transport)|go:"GO:1904109"(positive regulation of cholesterol import)|go:"GO:1904121"(phosphatidylethanolamine transfer activity)|interpro:IPR003033(Sterol-binding)|interpro:IPR016039(Thiolase-like)|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|interpro:IPR036527|mint:P32020|go:"GO:0006637"(acyl-CoA metabolic process)|ensembl:ENSMUSG00000028603(gene)|ensembl:ENSMUST00000030340(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:IpeZbl/Hw0r6QueEBBV8WBaMnNM10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P24270	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2924912|uniprotkb:Q3TXQ6|ensembl:ENSMUSP00000028610	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:cata_mouse(display_long)|uniprotkb:Cat(gene name)|psi-mi:Cat(display_short)|uniprotkb:Cas-1(gene name synonym)|uniprotkb:Cas1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0055093"(response to hyperoxia)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0080184"(response to phenylpropanoid)|interpro:IPR002226(Catalase)|interpro:IPR010582(Catalase-related)|interpro:IPR011614(Catalase, N-terminal)|interpro:IPR018028|interpro:IPR020835|interpro:IPR024708|interpro:IPR024711|interpro:IPR040333|mint:P24270|reactome:R-MMU-3299685|reactome:R-MMU-6798695|reactome:R-MMU-9033241|go:"GO:0051781"(positive regulation of cell division)|ensembl:ENSMUSG00000027187(gene)|ensembl:ENSMUST00000028610(transcript)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0004096"(catalase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009642"(response to light intensity)|go:"GO:0009650"(UV protection)|go:"GO:0010193"(response to ozone)|go:"GO:0010288"(response to lead ion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0016209"(antioxidant activity)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019899"(enzyme binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|refseq:NP_033934.2	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Ahsw8/VMIQAUw7mWuBSFRn9g/3M10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q5SRY7	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-11073522|uniprotkb:Q923H0|uniprotkb:Q3TLZ8|uniprotkb:Q3TGM9|uniprotkb:Q8K022|uniprotkb:Q8BY90|ensembl:ENSMUSP00000090893	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fbw1b_mouse(display_long)|uniprotkb:Fbxw11(gene name)|psi-mi:Fbxw11(display_short)|uniprotkb:Btrcp2(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:Fbw1b(gene name synonym)|uniprotkb:Fbxw1b(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001258276.1|refseq:NP_001258277.1|refseq:NP_001258278.1|refseq:NP_598776.1|ensembl:ENSMUSG00000020271(gene)|ensembl:ENSMUST00000093205(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048511"(rhythmic process)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q5SRY7|reactome:R-MMU-1169091|reactome:R-MMU-202424|reactome:R-MMU-2565942|reactome:R-MMU-2871837|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5676590|reactome:R-MMU-5684264|reactome:R-MMU-8951664|reactome:R-MMU-983168|dip:DIP-59921N	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:ahDg2ntR1uE9TEaFa8xgmsH3Ijg10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P11087	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1634830|uniprotkb:Q53WT0|uniprotkb:Q60635|uniprotkb:Q61367|uniprotkb:Q61427|uniprotkb:Q63919|uniprotkb:Q6PCL3|uniprotkb:Q810J9|ensembl:ENSMUSP00000001547	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:co1a1_mouse(display_long)|uniprotkb:Col1a1(gene name)|psi-mi:Col1a1(display_short)|uniprotkb:Cola1(gene name synonym)|uniprotkb:Alpha-1 type I collagen(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_031768.2|ensembl:ENSMUSG00000001506(gene)|ensembl:ENSMUST00000001547(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0001958"(endochondral ossification)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005584"(collagen type I trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0015031"(protein transport)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032355"(response to estradiol)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034505"(tooth mineralization)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043588"(skin development)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044691"(tooth eruption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0051591"(response to cAMP)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071306"(cellular response to vitamin E)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902618"(cellular response to fluoride)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR008160(Collagen triple helix repeat)|mint:P11087|reactome:R-MMU-114604|reactome:R-MMU-1442490|reactome:R-MMU-1474244|reactome:R-MMU-1650814|reactome:R-MMU-198933|reactome:R-MMU-2022090|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-2214320|reactome:R-MMU-2243919|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-430116|reactome:R-MMU-75892|reactome:R-MMU-76009|reactome:R-MMU-8874081|reactome:R-MMU-8948216|go:"GO:0002020"(protease binding)	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:mZrc8e1VDJc4u6y4zXOj0glFj9410090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P35441	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-6171593	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tsp1_mouse(display_long)|uniprotkb:Thbs1(gene name)|psi-mi:Thbs1(display_short)|uniprotkb:Tsp1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0043236"(laminin binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|reactome:R-MMU-114608|reactome:R-MMU-186797|reactome:R-MMU-216083|reactome:R-MMU-5173214|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016477"(cell migration)|interpro:IPR001881(EGF-like calcium-binding)|mint:P35441|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR017897|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:0j9TPpvxNW9TNMFkFCNo+9wD3fA10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q6GQT1	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26473702|ensembl:ENSMUSP00000032203|uniprotkb:E9QMQ7|uniprotkb:Q811S0	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:a2mg_mouse(display_long)|uniprotkb:A2m(gene name)|psi-mi:A2m(display_short)|uniprotkb:A2mp(gene name synonym)|uniprotkb:Alpha-2-macroglobulin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000030111(gene)|ensembl:ENSMUST00000032203(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007565"(female pregnancy)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048863"(stem cell differentiation)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR019742|interpro:IPR036595|interpro:IPR040839|interpro:IPR041555|interpro:IPR041813|mint:Q6GQT1|reactome:R-MMU-114608|reactome:R-MMU-140837|reactome:R-MMU-1474228|reactome:R-MMU-8963896|refseq:NP_783327.2	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:uf5Mk7VLjnfs0IkZp4CoUuuAkb010090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q91VN4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-776230|uniprotkb:Q3UNQ1|uniprotkb:Q9D5I5|uniprotkb:Q9DAM8|ensembl:ENSMUSP00000032172	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mic25_mouse(display_long)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 6(gene name synonym)|uniprotkb:Mic25(gene name synonym)|uniprotkb:Chchd6(gene name)|psi-mi:Chchd6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001161208.1|refseq:NP_079627.3|ensembl:ENSMUSG00000030086(gene)|ensembl:ENSMUST00000032172(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|interpro:IPR042860|mint:Q91VN4	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Op64pUsaaQVJ4d+W9vkGMMkgI8810090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P63330	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-397144|uniprotkb:O88591|uniprotkb:P13353|uniprotkb:Q5SNY5|ensembl:ENSMUSP00000020608	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:pp2aa_mouse(display_long)|uniprotkb:Ppp2ca(gene name)|psi-mi:Ppp2ca(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_062284.1|ensembl:ENSMUSG00000020349(gene)|ensembl:ENSMUST00000020608(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007498"(mesoderm development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1990405"(protein antigen binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:P63330|reactome:R-MMU-113501|reactome:R-MMU-1295596|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2995383|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-4641262|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6804757|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-9648025|reactome:R-MMU-975957	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:gpR5Fal3vi6O6cteeGwW72EuctY10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q6P1F6	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-997427|ensembl:ENSMUSP00000086640	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:2aba_mouse(display_long)|uniprotkb:PP2A subunit B isoform alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-alpha(gene name synonym)|uniprotkb:Ppp2r2a(gene name)|psi-mi:Ppp2r2a(display_short)|uniprotkb:PP2A subunit B isoform R2-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001192117.1|refseq:NP_082308.1|ensembl:ENSMUSG00000022052(gene)|ensembl:ENSMUST00000089230(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0043278"(response to morphine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:Q6P1F6|reactome:R-MMU-2995383|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-975957	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:evS6klM2alZXtMthVsshKkrNgiA10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8VCK3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-17170916|ensembl:ENSMUSP00000045901	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tbg2_mouse(display_long)|uniprotkb:Gamma-2-tubulin(gene name synonym)|uniprotkb:Tubg2(gene name)|psi-mi:Tubg2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000045007(gene)|ensembl:ENSMUST00000043654(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|interpro:IPR000217(Tubulin)|interpro:IPR002454(Gamma tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q8VCK3|reactome:R-MMU-380270|reactome:R-MMU-380320|refseq:NP_598789.1	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:ebQHblMVkTKA8wnY1ae2fdPzx8I10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9JL26	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-772250|uniprotkb:Q6KAN4|uniprotkb:Q9Z2V7|ensembl:ENSMUSP00000046296	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fmnl1_mouse(display_long)|uniprotkb:Formin-related protein(gene name synonym)|uniprotkb:Fmnl1(gene name)|psi-mi:Fmnl1(display_short)|uniprotkb:Frl(gene name synonym)|uniprotkb:Frl1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001071166.1|refseq:NP_062653.2|ensembl:ENSMUSG00000055805(gene)|ensembl:ENSMUST00000042286(transcript)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009987"(cellular process)|go:"GO:0016477"(cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027657|interpro:IPR042201|interpro:IPR043592|mint:Q9JL26|reactome:R-MMU-5663220|reactome:R-MMU-9013148|reactome:R-MMU-9013149	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:TStYWzz5LdFY4BeOWifTZyl6uTw10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8C0D4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472248|ensembl:ENSMUSP00000138585|uniprotkb:Q8BVP8	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:rhg12_mouse(display_long)|uniprotkb:Arhgap12(gene name)|psi-mi:Arhgap12(display_short)|uniprotkb:Rho-type GTPase-activating protein 12(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000041225(gene)|ensembl:ENSMUST00000182559(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035491|interpro:IPR036020|interpro:IPR036028|mint:Q8C0D4|rcsb pdb:6GVC|reactome:R-MMU-9013149|reactome:R-MMU-9013405|reactome:R-MMU-9013424|reactome:R-MMU-9035034|refseq:NP_001034781.1|refseq:NP_083553.2	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:daP4oZJo5g2WAFHv8quvfttZ0H810090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q76MZ3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-400413|ensembl:ENSMUSP00000007708	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:2aaa_mouse(display_long)|uniprotkb:Ppp2r1a(gene name)|psi-mi:Ppp2r1a(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_058587.1|go:"GO:0051306"(mitotic sister chromatid separation)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903538"(regulation of meiotic cell cycle process involved in oocyte maturation)|go:"GO:1990405"(protein antigen binding)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:Q76MZ3|rcsb pdb:2IAE|rcsb pdb:2PF4|rcsb pdb:3FGA|rcsb pdb:6EF4|reactome:R-MMU-113501|reactome:R-MMU-1295596|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-2995383|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-4641262|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6804757|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-8854518|reactome:R-MMU-9648025|reactome:R-MMU-975957|ensembl:ENSMUSG00000007564(gene)|ensembl:ENSMUST00000007708(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030425"(dendrite)|go:"GO:0045202"(synapse)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051232"(meiotic spindle elongation)|dip:DIP-29429N	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:0tnO11U1SNOOT46j23f7dim8O8k10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:G5E8P0	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2554025|ensembl:ENSMUSP00000104977|intact:EBI-11600212|uniprotkb:Q6PFC6|uniprotkb:Q6ZPK3|uniprotkb:Q8BWI2	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp6_mouse(display_long)|uniprotkb:Tubgcp6(gene name)|psi-mi:Tubgcp6(display_short)|uniprotkb:Kiaa1669(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001156791.1|ensembl:ENSMUSG00000051786(gene)|ensembl:ENSMUST00000109353(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR042241|mint:G5E8P0|reactome:R-MMU-380270|reactome:R-MMU-380320|interpro:IPR041470	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:o8N6a4n0HmcfpjPF0YcWNZVH39c10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P58854	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2551135|ensembl:ENSMUSP00000000776|uniprotkb:Q6PDQ9	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp3_mouse(display_long)|uniprotkb:Gcp3(gene name synonym)|uniprotkb:Tubgcp3(gene name)|psi-mi:Tubgcp3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	reactome:R-MMU-380320|ensembl:ENSMUSG00000000759(gene)|ensembl:ENSMUST00000000776(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005827"(polar microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:P58854|reactome:R-MMU-380270|refseq:NP_932148.1	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:qyzJzan6HpBMaAAOyhPM+94ecQA10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P21550	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1634301|ensembl:ENSMUSP00000072620|ensembl:ENSMUSP00000104188|ensembl:ENSMUSP00000128714	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:enob_mouse(display_long)|uniprotkb:Eno3(gene name)|psi-mi:Eno3(display_short)|uniprotkb:Eno-3(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Muscle-specific enolase(gene name synonym)|uniprotkb:Skeletal muscle enolase(gene name synonym)|uniprotkb:Enolase 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001129534.1|refseq:NP_031959.1|refseq:NP_001263214.1|refseq:XP_006532225.1|ensembl:ENSMUSG00000060600(gene)|ensembl:ENSMUST00000072841(transcript)|ensembl:ENSMUST00000108548(transcript)|ensembl:ENSMUST00000170716(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0007568"(aging)|go:"GO:0016020"(membrane)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P21550|reactome:R-MMU-70171|reactome:R-MMU-70263	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:CN/5EMhCFqpjAxZ04UHwcLN+eRI10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q3UHB8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-16731180|ensembl:ENSMUSP00000072982|uniprotkb:Q6NXJ5	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:cc177_mouse(display_long)|uniprotkb:Ccdc177(gene name)|psi-mi:Ccdc177(display_short)|uniprotkb:Gm1568(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000062961(gene)|ensembl:ENSMUST00000073251(transcript)|interpro:IPR029090|mint:Q3UHB8|refseq:NP_001008423.2	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:objGQkpHL5Pr4FZHhKDHYGjAVUU10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P83887	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2553410|ensembl:ENSMUSP00000048036|uniprotkb:Q9Z310	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tbg1_mouse(display_long)|uniprotkb:Tubg1(gene name)|psi-mi:Tubg1(display_short)|uniprotkb:Tubg(gene name synonym)|uniprotkb:Gamma-1-tubulin(gene name synonym)|uniprotkb:Gamma-tubulin complex component 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000035198(gene)|ensembl:ENSMUST00000043680(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005827"(polar microtubule)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005929"(cilium)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0055037"(recycling endosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000217(Tubulin)|interpro:IPR002454(Gamma tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|go:"GO:0005525"(GTP binding)|interpro:IPR037103|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518|mint:P83887|refseq:NP_598785.1	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:vuOzSmoj6s4iR1pV9zNfwxYjue810090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9WV30	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472334|ensembl:ENSMUSP00000116094|uniprotkb:E9Q0P3|uniprotkb:E9Q6U2|uniprotkb:G5E8N9|uniprotkb:Q91WY0|uniprotkb:Q9JLA1	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:nfat5_mouse(display_long)|uniprotkb:Nfat5(gene name)|psi-mi:Nfat5(display_short)|uniprotkb:Rel domain-containing transcription factor NFAT5(gene name synonym)|uniprotkb:T-cell transcription factor NFAT5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000003847(gene)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0010628"(positive regulation of gene expression)|ensembl:ENSMUST00000125721(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|interpro:IPR011539(Rel homology)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0005634"(nucleus)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0005654"(nucleoplasm)|interpro:IPR015646(Nuclear factor of activated T-cells 5)|interpro:IPR032397|interpro:IPR037059|mint:Q9WV30|refseq:NP_001273189.1|refseq:NP_061293.2|refseq:NP_598718.2|refseq:XP_006531255.1|refseq:XP_017168393.1	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Yf1n8cmeTkVMCL5aw+LQZwrAIcM10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8BUR9	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2553237|ensembl:ENSMUSP00000037557	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mzt1_mouse(display_long)|uniprotkb:Mzt1(gene name)|psi-mi:Mzt1(display_short)|uniprotkb:Mozart1(gene name synonym)|uniprotkb:Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUST00000042662(transcript)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0033566"(gamma-tubulin complex localization)|go:"GO:0051415"(microtubule nucleation by interphase microtubule organizing center)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR022214|mint:Q8BUR9|reactome:R-MMU-380270|reactome:R-MMU-380320|ensembl:ENSMUSG00000033186(gene)|refseq:NP_780454.1	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:a686Bpxk37Kl0gKKTz14f6sq6s410090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q921G8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2552389|ensembl:ENSMUSP00000026547|uniprotkb:G5E859	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp2_mouse(display_long)|uniprotkb:Gcp2(gene name synonym)|uniprotkb:Tubgcp2(gene name)|psi-mi:Tubgcp2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001272936.1|ensembl:ENSMUSG00000025474(gene)|ensembl:ENSMUST00000026547(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0001764"(neuron migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007420"(brain development)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:Q921G8|reactome:R-MMU-380270|reactome:R-MMU-380320|go:"GO:0000923"(equatorial microtubule organizing center)|refseq:NP_598516.2	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:rWPzsdt3ECnxr+ksi4MaH7okQ+M10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P54071	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-773401|uniprotkb:Q8C2R9|uniprotkb:Q9EQK1|ensembl:ENSMUSP00000103007	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:idhp_mouse(display_long)|uniprotkb:Oxalosuccinate decarboxylase(gene name synonym)|uniprotkb:"NADP(+)-specific ICDH"(gene name synonym)|uniprotkb:IDP(gene name synonym)|uniprotkb:ICD-M(gene name synonym)|uniprotkb:Idh2(gene name)|psi-mi:Idh2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_766599.2|ensembl:ENSMUSG00000030541(gene)|ensembl:ENSMUST00000107384(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004448"(isocitrate dehydrogenase activity)|go:"GO:0004450"("isocitrate dehydrogenase (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0006741"(NADP biosynthetic process)|go:"GO:0051287"(NAD binding)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:1903976"(negative regulation of glial cell migration)|go:"GO:1904465"(negative regulation of matrix metallopeptidase secretion)|interpro:IPR004790(Isocitrate dehydrogenase NADP-dependent, eukaryotic)|interpro:IPR019818|interpro:IPR024084|mint:P54071|rcsb pdb:5H3E|rcsb pdb:5H3F|reactome:R-MMU-2151201|reactome:R-MMU-71403	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:CkBZHIePaNGTtcgyqEf03oczVM010090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q3UHD3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472278|ensembl:ENSMUSP00000082694|uniprotkb:B9EKJ2|uniprotkb:Q7TPP7|uniprotkb:Q8CHD2|uniprotkb:Q9CY74	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mtus2_mouse(display_long)|uniprotkb:Mtus2(gene name)|psi-mi:Mtus2(display_short)|uniprotkb:Cazip(gene name synonym)|uniprotkb:Kiaa0774(gene name synonym)|uniprotkb:Tip150(gene name synonym)|uniprotkb:Cardiac zipper protein(gene name synonym)|uniprotkb:Microtubule plus-end tracking protein TIP150(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000029651(gene)|ensembl:ENSMUST00000085558(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR033339|mint:Q3UHD3|refseq:NP_084196.4|refseq:XP_006504953.1	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:42tgoThcDyvR8GE7irQd8rHlKL410090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P33215	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2366213|uniprotkb:Q6NXV3|uniprotkb:Q8BN12|uniprotkb:Q8BN86|uniprotkb:Q8BQL9|uniprotkb:Q9CWK2|ensembl:ENSMUSP00000020163	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:nedd1_mouse(display_long)|uniprotkb:Nedd1(gene name)|psi-mi:Nedd1(display_short)|uniprotkb:Nedd-1(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032708.2|ensembl:ENSMUSG00000019988(gene)|ensembl:ENSMUST00000020163(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000922"(spindle pole)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0031109"(microtubule polymerization or depolymerization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045177"(apical part of cell)|go:"GO:0051301"(cell division)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P33215|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:xBFWC64fRlKEVonqdYWgcVEPK0010090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9QXL8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472305	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:ndk7_mouse(display_long)|uniprotkb:Nme7(gene name)|psi-mi:Nme7(display_short)|uniprotkb:nm23-M7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	reactome:R-MMU-380320|go:"GO:0003351"(epithelial cilium movement involved in extracellular fluid movement)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005813"(centrosome)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0060830"(ciliary receptor clustering involved in smoothened signaling pathway)|go:"GO:0060972"(left/right pattern formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|reactome:R-MMU-380270|mint:Q9QXL8|interpro:IPR034907|interpro:IPR036850|interpro:IPR011410(Nucleoside diphosphate kinase, NDK7)|interpro:IPR035525|interpro:IPR037993|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR006602(Region of unknown function DM10)	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:zkOjHmuz7jAgTi/5/MQYROLtVKg10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P01027	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-4281083|uniprotkb:Q80XP1|ensembl:ENSMUSP00000024988|uniprotkb:Q61370	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:co3_mouse(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:HSE-MSF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000024164(gene)|ensembl:ENSMUST00000024988(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008289"(lipid binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01027|rcsb pdb:6XZU|reactome:R-MMU-173736|reactome:R-MMU-174577|reactome:R-MMU-198933|reactome:R-MMU-375276|reactome:R-MMU-381426|reactome:R-MMU-418594|reactome:R-MMU-6798695|reactome:R-MMU-8957275|reactome:R-MMU-977606|refseq:NP_033908.2	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:VGFRYhKETrS9O7cyeJZyxBFgBL410090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9CQ25	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2552037|ensembl:ENSMUSP00000023351|ensembl:ENSMUSP00000113832	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mzt2_mouse(display_long)|uniprotkb:Fam128b(gene name synonym)|uniprotkb:Mozart2(gene name synonym)|uniprotkb:Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B(gene name synonym)|uniprotkb:Mzt2(gene name)|psi-mi:Mzt2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|interpro:IPR024332|ensembl:ENSMUSG00000022671(gene)|mint:Q9CQ25|reactome:R-MMU-380270|reactome:R-MMU-380320|ensembl:ENSMUST00000023351(transcript)|ensembl:ENSMUST00000117136(transcript)|refseq:NP_083630.1|refseq:XP_006522651.1	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:heL4NryOHurQ03jZtyHwM/D5Xe810090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P11276	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-641955|uniprotkb:G5E8B8|uniprotkb:Q61567|uniprotkb:Q61568|uniprotkb:Q61569|uniprotkb:Q64233|uniprotkb:Q80UI4|ensembl:ENSMUSP00000054499	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:finc_mouse(display_long)|uniprotkb:Fn1(gene name)|psi-mi:Fn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_034363.1|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P11276|rcsb pdb:1MFN|rcsb pdb:2MFN|reactome:R-MMU-114608|reactome:R-MMU-1474228|reactome:R-MMU-1474244|reactome:R-MMU-1566977|reactome:R-MMU-202733|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000170|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381426|reactome:R-MMU-5674135|reactome:R-MMU-8874081|reactome:R-MMU-8957275|ensembl:ENSMUSG00000026193(gene)|ensembl:ENSMUST00000055226(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005577"(fibrinogen complex)	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:qndGPG6vmzpIIkDuO1BrVRI1oPg10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8BKN5	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-11075667|uniprotkb:Q8C083|uniprotkb:Q69Z75|uniprotkb:Q8BLJ9|uniprotkb:Q3U8X5|ensembl:ENSMUSP00000032627	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp5_mouse(display_long)|uniprotkb:Tubgcp5(gene name)|psi-mi:Tubgcp5(display_short)|uniprotkb:Kiaa1899(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_666302.2|ensembl:ENSMUSG00000033790(gene)|ensembl:ENSMUST00000032627(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008017"(microtubule binding)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|interpro:IPR042241|mint:Q8BKN5|reactome:R-MMU-380270|reactome:R-MMU-380320	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:1BOIJxOyERW8OOgl7YGHj9W2PMw10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9CQR4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-299825|ensembl:ENSMUSP00000006900	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:aco13_mouse(display_long)|uniprotkb:Acot13(gene name)|psi-mi:Acot13(display_short)|uniprotkb:Hotdog-fold thioesterase superfamily member 2(gene name synonym)|uniprotkb:Palmitoyl-CoA hydrolase(gene name synonym)|uniprotkb:Them2(gene name synonym)|uniprotkb:Thioesterase superfamily member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473930|imex:IM-28526-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000006717(gene)|ensembl:ENSMUST00000006900(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR003736(Phenylacetic acid degradation-related protein)|interpro:IPR006683(Thioesterase superfamily)|interpro:IPR029069|interpro:IPR039298|mint:Q9CQR4|rcsb pdb:2CY9|reactome:R-MMU-77289|refseq:NP_080066.1	-	-	-	figure legend:ST5|comment:"Q140 mice, 2 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:jMok2ZPtX2ETleMlnA+90d/FVxs10090	rigid:b49MohFocjek5KnmaVg+AZ47fnA	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q61704	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8320806|intact:MINT-4099088|uniprotkb:E9QME9|uniprotkb:Q91WG9|ensembl:ENSMUSP00000006697	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:itih3_mouse(display_long)|uniprotkb:Itih3(gene name)|psi-mi:Itih3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032433.2|ensembl:ENSMUSG00000006522(gene)|ensembl:ENSMUST00000006697(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010600(Inter-alpha-trypsin inhibitor heavy chain, C-terminal)|interpro:IPR013694(Vault protein inter-alpha-trypsin)|interpro:IPR036465|mint:Q61704|reactome:R-MMU-114608	-	-	function:May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes|comment:mint	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Pdi9OY15tRMIbi72dbN6I0+9U1A10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:O88783	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8391075|uniprotkb:Q3UV80|intact:MINT-4105665|uniprotkb:Q3UTQ2|ensembl:ENSMUSP00000083204	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fa5_mouse(display_long)|uniprotkb:F5(gene name)|psi-mi:F5(display_short)|uniprotkb:Activated protein C cofactor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032002.1|ensembl:ENSMUSG00000026579(gene)|ensembl:ENSMUST00000086040(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0031091"(platelet alpha granule)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011707(Multicopper oxidase, type 3)|interpro:IPR024715|interpro:IPR033138|mint:O88783|reactome:R-MMU-114608|reactome:R-MMU-140875|reactome:R-MMU-204005|reactome:R-MMU-381426|reactome:R-MMU-5694530|reactome:R-MMU-8957275	-	-	comment:mint	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:uKDUvdqfAad11uLZ1qznjhrHu+410090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q2TPA8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8346446|uniprotkb:Q3ULY5|uniprotkb:Q3UVZ3|intact:MINT-1860458|uniprotkb:Q99LV2|uniprotkb:Q8C3H3|ensembl:ENSMUSP00000030078	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:hsdl2_mouse(display_long)|uniprotkb:Hsdl2(gene name)|psi-mi:Hsdl2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_077217.2|ensembl:ENSMUSG00000028383(gene)|ensembl:ENSMUST00000030078(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR003033(Sterol-binding)|interpro:IPR036291|interpro:IPR036527|mint:Q2TPA8	-	-	comment:mint	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:EuUAecUkC7gRKu9bZnI12W9iz6w10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P04186	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8346300|intact:MINT-1865229|ensembl:ENSMUSP00000119977	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:cfab_mouse(display_long)|uniprotkb:Cfb(gene name)|psi-mi:Cfb(display_short)|uniprotkb:Bf(gene name synonym)|uniprotkb:H2-Bf(gene name synonym)|uniprotkb:C3/C5 convertase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000090231(gene)|ensembl:ENSMUST00000128767(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0097066"(response to thyroid hormone)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011360(Complement B/C2)|interpro:IPR018114|interpro:IPR028341|interpro:IPR033116|interpro:IPR035976|interpro:IPR036465|mint:P04186|reactome:R-MMU-173736|reactome:R-MMU-174577|reactome:R-MMU-977606	-	-	comment:mint|function:"Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase"	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:ZIuU2m3OfhhdoW+STWEfOv2i9QM10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q925E7	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8322442|intact:MINT-4086270|uniprotkb:Q6ZPN5|ensembl:ENSMUSP00000040321	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:2abd_mouse(display_long)|uniprotkb:Ppp2r2d(gene name)|psi-mi:Ppp2r2d(display_short)|uniprotkb:D7Ertd753e(gene name synonym)|uniprotkb:Kiaa1541(gene name synonym)|uniprotkb:PP2A subunit B isoform delta(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-delta(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-delta(gene name synonym)|uniprotkb:PP2A subunit B isoform R2-delta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_080667.1|ensembl:ENSMUSG00000041769(gene)|ensembl:ENSMUST00000041097(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005829"(cytosol)|go:"GO:0010458"(exit from mitosis)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0051301"(cell division)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:Q925E7	-	-	function:The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment|comment:mint	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Zh/H8rSp0CYazGt4SwUz+532bJQ10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q921H8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8330006|intact:MINT-1858351|ensembl:ENSMUSP00000042351	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:thika_mouse(display_long)|uniprotkb:Acetyl-CoA C-myristoyltransferase(gene name synonym)|uniprotkb:Acaa1a(gene name)|psi-mi:Acaa1a(display_short)|uniprotkb:Acaa1(gene name synonym)|uniprotkb:Beta-ketothiolase A(gene name synonym)|uniprotkb:Acetyl-CoA acyltransferase A(gene name synonym)|uniprotkb:Peroxisomal 3-oxoacyl-CoA thiolase A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_570934.1|refseq:XP_006511986.1|ensembl:ENSMUSG00000036138(gene)|ensembl:ENSMUST00000039784(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008775"(acetate CoA-transferase activity)|go:"GO:0010124"(phenylacetate catabolic process)|go:"GO:0016401"(palmitoyl-CoA oxidase activity)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:Q921H8|reactome:R-MMU-2046106|reactome:R-MMU-390247|reactome:R-MMU-6798695|reactome:R-MMU-9033241	-	-	comment:mint	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:A7f6/enaS9RJZ+DDXxVXXa/9vTU10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P19221	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8375972|intact:MINT-4137721|ensembl:ENSMUSP00000028681	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:thrb_mouse(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Cf2(gene name synonym)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_034298.1|dip:DIP-60968N|ensembl:ENSMUSG00000027249(gene)|ensembl:ENSMUST00000028681(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|interpro:IPR035972|interpro:IPR037111|interpro:IPR038178|interpro:IPR043504|mint:P19221|rcsb pdb:2OCV|rcsb pdb:2PUX|rcsb pdb:2PV9|rcsb pdb:3EDX|rcsb pdb:3HK3|rcsb pdb:3HK6|rcsb pdb:3HKI|reactome:R-MMU-140837|reactome:R-MMU-140875|reactome:R-MMU-159740|reactome:R-MMU-159763|reactome:R-MMU-159782|reactome:R-MMU-202733|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-456926|reactome:R-MMU-76009|reactome:R-MMU-977606	-	-	comment:mint|function:Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:amZ+Pl0pNliSHuykYcjQLfqb1vw10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P51660	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8328056|intact:MINT-1859569|intact:MINT-2512164|uniprotkb:Q9DBM3|ensembl:ENSMUSP00000025385	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:dhb4_mouse(display_long)|uniprotkb:Hsd17b4(gene name)|psi-mi:Hsd17b4(display_short)|uniprotkb:Edh17b4(gene name synonym)|uniprotkb:Multifunctional protein 2(gene name synonym)|uniprotkb:D-bifunctional protein(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032318.2|ensembl:ENSMUSG00000024507(gene)|ensembl:ENSMUST00000025385(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0004303"(estradiol 17-beta-dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0033989"(3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity)|go:"GO:0036111"(very long-chain fatty-acyl-CoA metabolic process)|go:"GO:0036112"(medium-chain fatty-acyl-CoA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0060009"(Sertoli cell development)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR002539(MaoC-like dehydratase)|interpro:IPR003033(Sterol-binding)|interpro:IPR020904|interpro:IPR029069|interpro:IPR036291|interpro:IPR036527|mint:P51660|reactome:R-MMU-193368|reactome:R-MMU-2046106|reactome:R-MMU-389887|reactome:R-MMU-390247|reactome:R-MMU-9033241	-	-	function:Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids|comment:mint	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:71hLYwG2pK+0vOd5eF+qYIa7J5I10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9D4F8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-7780439|ensembl:ENSMUSP00000044049|intact:UNK-5542993	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp4_mouse(display_long)|uniprotkb:Tubgcp4(gene name)|psi-mi:Tubgcp4(display_short)|uniprotkb:D2Ertd435e(gene name synonym)|uniprotkb:Gcp4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000027263(gene)|ensembl:ENSMUST00000039541(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005813"(centrosome)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0055037"(recycling endosome)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|interpro:IPR042241|mint:Q9D4F8|reactome:R-MMU-380270|reactome:R-MMU-380320|go:"GO:0005874"(microtubule)|refseq:NP_700436.1	-	-	function:Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome|comment:mint	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:uoyvScV5OQTR+AqUMMIYMhe/a/Q10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8R4H2	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-8046267|intact:MINT-1774761|uniprotkb:E9QPW9|uniprotkb:Q80U18|ensembl:ENSMUSP00000072547	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:arhgc_mouse(display_long)|uniprotkb:Arhgef12(gene name)|psi-mi:Arhgef12(display_short)|uniprotkb:Kiaa0382(gene name synonym)|uniprotkb:Larg(gene name synonym)|uniprotkb:Leukemia-associated RhoGEF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:XP_006510649.1|ensembl:ENSMUSG00000059495(gene)|ensembl:ENSMUST00000072767(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037801|interpro:IPR037884|interpro:IPR041020|mint:Q8R4H2|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148	-	-	comment:mint|function:"May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13"	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:5ZclDYjaUBilqiB548/6M5KlhVg10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P20918	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-5607005|uniprotkb:Q8CIS2|uniprotkb:Q91WJ5|ensembl:ENSMUSP00000014578	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:plmn_mouse(display_long)|uniprotkb:Plg(gene name)|psi-mi:Plg(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032903.3|ensembl:ENSMUSG00000059481(gene)|ensembl:ENSMUST00000014578(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007596"(blood coagulation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042730"(fibrinolysis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048771"(tissue remodeling)|go:"GO:0051087"(chaperone binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0051919"(positive regulation of fibrinolysis)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071674"(mononuclear cell migration)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099183"(trans-synaptic signaling by BDNF, modulating synaptic transmission)|go:"GO:1990405"(protein antigen binding)|interpro:IPR000001(Kringle)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003609(Apple-like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR018114|interpro:IPR023317|interpro:IPR033116|interpro:IPR038178|interpro:IPR043504|mint:P20918|reactome:R-MMU-114608|reactome:R-MMU-1474228|reactome:R-MMU-1592389|reactome:R-MMU-186797|reactome:R-MMU-75205|reactome:R-MMU-8964041	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:IOfMej57pCeThxfeTAXEGlU7Hy410090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9R0L6	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-4284371|uniprotkb:O70287|uniprotkb:Q3URH6|uniprotkb:Q7TMS7|uniprotkb:Q8C9V2|uniprotkb:Q91Y27|uniprotkb:Q91Y28|uniprotkb:Q91Y51|uniprotkb:Q9CRK8|uniprotkb:Q923L0|uniprotkb:Q9CT57|uniprotkb:E9QLK2|ensembl:ENSMUSP00000039709	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:pcm1_mouse(display_long)|uniprotkb:Pcm1(gene name)|psi-mi:Pcm1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_076151.2|refseq:XP_006509361.1|ensembl:ENSMUSG00000031592(gene)|ensembl:ENSMUST00000045218(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q9R0L6|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-5620912|reactome:R-MMU-8854518|reactome:R-MMU-380320	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:OT+ZOQY5pqQojMcLCWMIY+6zdl410090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:E9Q8I9	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-16732044|ensembl:ENSMUSP00000084454|uniprotkb:Q4VA57|uniprotkb:Q5DTL4|uniprotkb:Q8BIW6|uniprotkb:Q8BUA0|uniprotkb:Q8CG91	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fry_mouse(display_long)|uniprotkb:Fry(gene name)|psi-mi:Fry(display_short)|uniprotkb:Kiaa4143(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000056602(gene)|ensembl:ENSMUST00000087204(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005938"(cell cortex)|go:"GO:0030427"(site of polarized growth)|go:"GO:0031175"(neuron projection development)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025481|interpro:IPR025614|interpro:IPR029473|interpro:IPR039867|mint:E9Q8I9|refseq:NP_766475.2|refseq:XP_006504993.1	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:fvduzhqkwcM9qmnWvPWAA1W8HqI10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q99JP6	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-6272061|ensembl:ENSMUSP00000117033|uniprotkb:D3Z6N9|uniprotkb:Q9Z215	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:home3_mouse(display_long)|uniprotkb:Homer3(gene name)|psi-mi:Homer3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000003573(gene)|ensembl:ENSMUST00000140212(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q99JP6|reactome:R-MMU-6794361|refseq:NP_001139625.1|refseq:NP_036114.2	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:7IOPI8VTi6aKK/I0tl4AiUUIXIU10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9ES28	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-642580|uniprotkb:O08757|uniprotkb:Q3UTS5|uniprotkb:Q6XPA5|uniprotkb:Q6ZQI5|uniprotkb:Q8C750|uniprotkb:Q91ZZ6|uniprotkb:Q9ES27	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:arhg7_mouse(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:p85SPR(gene name synonym)|uniprotkb:Arhgef7(gene name)|psi-mi:Arhgef7(display_short)|uniprotkb:Pak3bp(gene name synonym)|uniprotkb:Kiaa0142(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001106989.1|refseq:NP_001106990.1|refseq:NP_059098.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|refseq:XP_006508906.2|refseq:XP_006508907.2|interpro:IPR032409|refseq:XP_006508904.2|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013424|go:"GO:0000322"(storage vacuole)|go:"GO:0001726"(ruffle)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030426"(growth cone)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099140"(presynaptic actin cytoskeleton organization)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|rcsb pdb:2ESW|rcsb pdb:6JMT|reactome:R-MMU-182971|reactome:R-MMU-193648|reactome:R-MMU-3928664|mint:Q9ES28|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:+Bie+UoaAI9/ldibUxAjNYc3sYs10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P32020	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-309563|uniprotkb:Q9DBM7|uniprotkb:A2APS2|uniprotkb:A2APS3|ensembl:ENSMUSP00000030340	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:scp2_mouse(display_long)|uniprotkb:Scp2(gene name)|psi-mi:Scp2(display_short)|uniprotkb:Scp-2(gene name synonym)|uniprotkb:Propanoyl-CoA C-acyltransferase(gene name synonym)|uniprotkb:Sterol carrier protein X(gene name synonym)|uniprotkb:SCP-chi(gene name synonym)|uniprotkb:Acetyl-CoA C-myristoyltransferase(gene name synonym)|uniprotkb:Non-specific lipid-transfer protein(gene name synonym)|uniprotkb:SCP-2/3-oxoacyl-CoA thiolase(gene name synonym)|uniprotkb:SCP-2/thiolase(gene name synonym)|uniprotkb:Straight-chain acyl-CoA oxidase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035457.1|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006701"(progesterone biosynthetic process)|go:"GO:0007031"(peroxisome organization)|go:"GO:0007568"(aging)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008526"(phosphatidylinositol transfer activity)|go:"GO:0010893"(positive regulation of steroid biosynthetic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032385"(positive regulation of intracellular cholesterol transport)|go:"GO:0032934"(sterol binding)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033814"(propanoyl-CoA C-acyltransferase activity)|go:"GO:0036042"(long-chain fatty acyl-CoA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045940"(positive regulation of steroid metabolic process)|go:"GO:0050632"(propionyl-CoA C2-trimethyltridecanoyltransferase activity)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|go:"GO:0070538"(oleic acid binding)|go:"GO:0071071"(regulation of phospholipid biosynthetic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0120019"(phosphatidylcholine transfer activity)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1901373"(lipid hydroperoxide transport)|go:"GO:1904109"(positive regulation of cholesterol import)|go:"GO:1904121"(phosphatidylethanolamine transfer activity)|interpro:IPR003033(Sterol-binding)|interpro:IPR016039(Thiolase-like)|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|interpro:IPR036527|mint:P32020|go:"GO:0006637"(acyl-CoA metabolic process)|ensembl:ENSMUSG00000028603(gene)|ensembl:ENSMUST00000030340(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:IpeZbl/Hw0r6QueEBBV8WBaMnNM10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q62383	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1373250|uniprotkb:Q5SYM0|uniprotkb:Q6GQS3|uniprotkb:Q6ZQI0|uniprotkb:Q8BQY6|ensembl:ENSMUSP00000002121	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:spt6h_mouse(display_long)|uniprotkb:Supt6h(gene name)|psi-mi:Supt6h(display_short)|uniprotkb:Kiaa0162(gene name synonym)|uniprotkb:Supt6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_033323.2|ensembl:ENSMUSG00000002052(gene)|ensembl:ENSMUST00000002121(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003677"(DNA binding)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008380"(RNA splicing)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034728"(nucleosome organization)|go:"GO:0035327"|go:"GO:0042393"(histone binding)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0051028"(mRNA transport)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0070827"(obsolete chromatin maintenance)|interpro:IPR000980(SH2 motif)|interpro:IPR003029(S1, RNA binding)|interpro:IPR006641(Resolvase, RNase H-like fold)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR017072(Transcription elongation factor Spt6)|interpro:IPR022967|interpro:IPR023319|interpro:IPR023323|interpro:IPR028083|interpro:IPR028088|interpro:IPR028231|interpro:IPR032706|interpro:IPR035018|interpro:IPR035019|interpro:IPR035420|interpro:IPR036860|interpro:IPR037027|interpro:IPR041692|interpro:IPR042066|mint:Q62383|reactome:R-MMU-112382|reactome:R-MMU-674695|reactome:R-MMU-75955	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:h9yOnI51aroUlQNPlgQzPlOquJs10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q921I1	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-761948|uniprotkb:O35421|uniprotkb:Q3UBW7|uniprotkb:Q58E69|uniprotkb:Q61803|uniprotkb:Q62357|uniprotkb:Q62358|uniprotkb:Q62359|uniprotkb:Q63915|uniprotkb:Q64515|uniprotkb:Q8VII5|uniprotkb:Q922C0|ensembl:ENSMUSP00000108264|ensembl:ENSMUSP00000035158	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:trfe_mouse(display_long)|uniprotkb:Siderophilin(gene name synonym)|uniprotkb:Beta-1 metal-binding globulin(gene name synonym)|uniprotkb:Tf(gene name)|psi-mi:Tf(display_short)|uniprotkb:Trf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_598738.1|ensembl:ENSMUSG00000032554(gene)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0097433"(dense body)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR001156(Peptidase S60, transferrin lactoferrin)|interpro:IPR016357(Transferrin)|interpro:IPR018195|interpro:IPR030685|mint:Q921I1|reactome:R-MMU-114608|reactome:R-MMU-381426|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8957275|reactome:R-MMU-917937|reactome:R-MMU-917977|ensembl:ENSMUST00000035158(transcript)|ensembl:ENSMUST00000112645(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007015"(actin filament organization)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030120"(vesicle coat)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0031982"(vesicle)|go:"GO:0034756"(regulation of iron ion transport)|go:"GO:0034986"(iron chaperone activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0045178"(basal part of cell)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0055037"(recycling endosome)|go:"GO:0009986"(cell surface)	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:V7U4fb+43G8NBKnZT/9PR+9HiQk10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P62962	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-647096|uniprotkb:P10924|ensembl:ENSMUSP00000018437	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:prof1_mouse(display_long)|uniprotkb:Profilin I(gene name synonym)|uniprotkb:Pfn1(gene name)|psi-mi:Pfn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035202.1|dip:DIP-38075N|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050821"(protein stabilization)|go:"GO:0051054"(positive regulation of DNA metabolic process)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060074"(synapse maturation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR005454(Profilin, Mammalian)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR029892|interpro:IPR036140|mint:P62962|reactome:R-MMU-376176|reactome:R-MMU-4086400|reactome:R-MMU-5663220|ensembl:ENSMUSG00000018293(gene)|ensembl:ENSMUST00000018437(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:nzOTw5XdywGrh+fA9AInGIexyGk10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P11087	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1634830|uniprotkb:Q53WT0|uniprotkb:Q60635|uniprotkb:Q61367|uniprotkb:Q61427|uniprotkb:Q63919|uniprotkb:Q6PCL3|uniprotkb:Q810J9|ensembl:ENSMUSP00000001547	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:co1a1_mouse(display_long)|uniprotkb:Col1a1(gene name)|psi-mi:Col1a1(display_short)|uniprotkb:Cola1(gene name synonym)|uniprotkb:Alpha-1 type I collagen(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_031768.2|ensembl:ENSMUSG00000001506(gene)|ensembl:ENSMUST00000001547(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0001958"(endochondral ossification)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005584"(collagen type I trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0015031"(protein transport)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032355"(response to estradiol)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034505"(tooth mineralization)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043588"(skin development)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044691"(tooth eruption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0051591"(response to cAMP)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071306"(cellular response to vitamin E)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902618"(cellular response to fluoride)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR008160(Collagen triple helix repeat)|mint:P11087|reactome:R-MMU-114604|reactome:R-MMU-1442490|reactome:R-MMU-1474244|reactome:R-MMU-1650814|reactome:R-MMU-198933|reactome:R-MMU-2022090|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-2214320|reactome:R-MMU-2243919|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-430116|reactome:R-MMU-75892|reactome:R-MMU-76009|reactome:R-MMU-8874081|reactome:R-MMU-8948216|go:"GO:0002020"(protease binding)	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:mZrc8e1VDJc4u6y4zXOj0glFj9410090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q5SRY7	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-11073522|uniprotkb:Q923H0|uniprotkb:Q3TLZ8|uniprotkb:Q3TGM9|uniprotkb:Q8K022|uniprotkb:Q8BY90|ensembl:ENSMUSP00000090893	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fbw1b_mouse(display_long)|uniprotkb:Fbxw11(gene name)|psi-mi:Fbxw11(display_short)|uniprotkb:Btrcp2(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:Fbw1b(gene name synonym)|uniprotkb:Fbxw1b(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001258276.1|refseq:NP_001258277.1|refseq:NP_001258278.1|refseq:NP_598776.1|ensembl:ENSMUSG00000020271(gene)|ensembl:ENSMUST00000093205(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048511"(rhythmic process)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q5SRY7|reactome:R-MMU-1169091|reactome:R-MMU-202424|reactome:R-MMU-2565942|reactome:R-MMU-2871837|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5676590|reactome:R-MMU-5684264|reactome:R-MMU-8951664|reactome:R-MMU-983168|dip:DIP-59921N	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:ahDg2ntR1uE9TEaFa8xgmsH3Ijg10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P06151	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-444940|ensembl:ENSMUSP00000036386|ensembl:ENSMUSP00000103267	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:ldha_mouse(display_long)|uniprotkb:LDH muscle subunit(gene name synonym)|uniprotkb:Ldha(gene name)|psi-mi:Ldha(display_short)|uniprotkb:Ldh-1(gene name synonym)|uniprotkb:Ldh1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_034829.1|ensembl:ENSMUSG00000063229(gene)|ensembl:ENSMUST00000005051(transcript)|ensembl:ENSMUST00000048209(transcript)|go:"GO:0004457"(lactate dehydrogenase activity)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019244"(lactate biosynthetic process from pyruvate)|go:"GO:0019661"(glucose catabolic process to lactate via pyruvate)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0042802"(identical protein binding)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P06151|reactome:R-MMU-70268	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:IErFuOIWq53/XyIxWgUyVi76VnM10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q6GQT1	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26473702|ensembl:ENSMUSP00000032203|uniprotkb:E9QMQ7|uniprotkb:Q811S0	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:a2mg_mouse(display_long)|uniprotkb:A2m(gene name)|psi-mi:A2m(display_short)|uniprotkb:A2mp(gene name synonym)|uniprotkb:Alpha-2-macroglobulin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000030111(gene)|ensembl:ENSMUST00000032203(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007565"(female pregnancy)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048863"(stem cell differentiation)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR019742|interpro:IPR036595|interpro:IPR040839|interpro:IPR041555|interpro:IPR041813|mint:Q6GQT1|reactome:R-MMU-114608|reactome:R-MMU-140837|reactome:R-MMU-1474228|reactome:R-MMU-8963896|refseq:NP_783327.2	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:uf5Mk7VLjnfs0IkZp4CoUuuAkb010090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P58252	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-773856|uniprotkb:Q544E4|ensembl:ENSMUSP00000046101	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:ef2_mouse(display_long)|uniprotkb:Eef2(gene name)|psi-mi:Eef2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_031933.1|ensembl:ENSMUSG00000034994(gene)|ensembl:ENSMUST00000047864(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006414"(translational elongation)|go:"GO:0007568"(aging)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016235"(aggresome)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051593"(response to folic acid)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031157|interpro:IPR035647|interpro:IPR041095|mint:P58252|reactome:R-MMU-156902|reactome:R-MMU-5358493|reactome:R-MMU-6798695	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:910/vo3IRjcncyPD4f43dPtS83o10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9WTX5	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-1202363|uniprotkb:Q8C5H6|ensembl:ENSMUSP00000038744|ensembl:ENSMUSP00000104700	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:skp1_mouse(display_long)|uniprotkb:Skp1(gene name)|psi-mi:Skp1(display_short)|uniprotkb:Skp1a(gene name synonym)|uniprotkb:S-phase kinase-associated protein 1A(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:p19A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_035673.3|refseq:XP_006532849.1|go:"GO:0019904"(protein domain specific binding)|ensembl:ENSMUSG00000036309(gene)|ensembl:ENSMUST00000037324(transcript)|ensembl:ENSMUST00000109072(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:Q9WTX5|reactome:R-MMU-1169091|reactome:R-MMU-1170546|reactome:R-MMU-187577|reactome:R-MMU-195253|reactome:R-MMU-202424|reactome:R-MMU-2565942|reactome:R-MMU-2871837|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5676590|reactome:R-MMU-5684264|reactome:R-MMU-68949|reactome:R-MMU-69231|reactome:R-MMU-8854050|reactome:R-MMU-8939902|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-917937|reactome:R-MMU-9708530|reactome:R-MMU-983168|dip:DIP-38596N	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:qGk720KMKAbBPguy2tmUOZsLxRQ10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q68FF6	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-645933|ensembl:ENSMUSP00000037210	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:git1_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 1(gene name synonym)|uniprotkb:GRK-interacting protein 1(gene name synonym)|uniprotkb:Git1(gene name)|psi-mi:Git1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001004144.1|ensembl:ENSMUSG00000011877(gene)|ensembl:ENSMUST00000037285(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032013"(negative regulation of ARF protein signal transduction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048666"(neuron development)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061743"(motor learning)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR032352|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q68FF6|rcsb pdb:6JMU|reactome:R-MMU-3928664|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:3br9Xz6GZQV409u3u7CZDfqKMIM10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P63330	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-397144|uniprotkb:O88591|uniprotkb:P13353|uniprotkb:Q5SNY5|ensembl:ENSMUSP00000020608	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:pp2aa_mouse(display_long)|uniprotkb:Ppp2ca(gene name)|psi-mi:Ppp2ca(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_062284.1|ensembl:ENSMUSG00000020349(gene)|ensembl:ENSMUST00000020608(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007498"(mesoderm development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1990405"(protein antigen binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:P63330|reactome:R-MMU-113501|reactome:R-MMU-1295596|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2995383|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-4641262|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6804757|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-9648025|reactome:R-MMU-975957	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:gpR5Fal3vi6O6cteeGwW72EuctY10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q6P1F6	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-997427|ensembl:ENSMUSP00000086640	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:2aba_mouse(display_long)|uniprotkb:PP2A subunit B isoform alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-alpha(gene name synonym)|uniprotkb:Ppp2r2a(gene name)|psi-mi:Ppp2r2a(display_short)|uniprotkb:PP2A subunit B isoform R2-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001192117.1|refseq:NP_082308.1|ensembl:ENSMUSG00000022052(gene)|ensembl:ENSMUST00000089230(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0043278"(response to morphine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:Q6P1F6|reactome:R-MMU-2995383|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-975957	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:evS6klM2alZXtMthVsshKkrNgiA10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8VCK3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-17170916|ensembl:ENSMUSP00000045901	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tbg2_mouse(display_long)|uniprotkb:Gamma-2-tubulin(gene name synonym)|uniprotkb:Tubg2(gene name)|psi-mi:Tubg2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000045007(gene)|ensembl:ENSMUST00000043654(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|interpro:IPR000217(Tubulin)|interpro:IPR002454(Gamma tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q8VCK3|reactome:R-MMU-380270|reactome:R-MMU-380320|refseq:NP_598789.1	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:ebQHblMVkTKA8wnY1ae2fdPzx8I10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9JL26	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-772250|uniprotkb:Q6KAN4|uniprotkb:Q9Z2V7|ensembl:ENSMUSP00000046296	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:fmnl1_mouse(display_long)|uniprotkb:Formin-related protein(gene name synonym)|uniprotkb:Fmnl1(gene name)|psi-mi:Fmnl1(display_short)|uniprotkb:Frl(gene name synonym)|uniprotkb:Frl1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001071166.1|refseq:NP_062653.2|ensembl:ENSMUSG00000055805(gene)|ensembl:ENSMUST00000042286(transcript)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009987"(cellular process)|go:"GO:0016477"(cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027657|interpro:IPR042201|interpro:IPR043592|mint:Q9JL26|reactome:R-MMU-5663220|reactome:R-MMU-9013148|reactome:R-MMU-9013149	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:TStYWzz5LdFY4BeOWifTZyl6uTw10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8C0D4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472248|ensembl:ENSMUSP00000138585|uniprotkb:Q8BVP8	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:rhg12_mouse(display_long)|uniprotkb:Arhgap12(gene name)|psi-mi:Arhgap12(display_short)|uniprotkb:Rho-type GTPase-activating protein 12(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000041225(gene)|ensembl:ENSMUST00000182559(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035491|interpro:IPR036020|interpro:IPR036028|mint:Q8C0D4|rcsb pdb:6GVC|reactome:R-MMU-9013149|reactome:R-MMU-9013405|reactome:R-MMU-9013424|reactome:R-MMU-9035034|refseq:NP_001034781.1|refseq:NP_083553.2	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:daP4oZJo5g2WAFHv8quvfttZ0H810090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q76MZ3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-400413|ensembl:ENSMUSP00000007708	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:2aaa_mouse(display_long)|uniprotkb:Ppp2r1a(gene name)|psi-mi:Ppp2r1a(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_058587.1|go:"GO:0051306"(mitotic sister chromatid separation)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903538"(regulation of meiotic cell cycle process involved in oocyte maturation)|go:"GO:1990405"(protein antigen binding)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:Q76MZ3|rcsb pdb:2IAE|rcsb pdb:2PF4|rcsb pdb:3FGA|rcsb pdb:6EF4|reactome:R-MMU-113501|reactome:R-MMU-1295596|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-2995383|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-4641262|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6804757|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-8854518|reactome:R-MMU-9648025|reactome:R-MMU-975957|ensembl:ENSMUSG00000007564(gene)|ensembl:ENSMUST00000007708(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030425"(dendrite)|go:"GO:0045202"(synapse)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051232"(meiotic spindle elongation)|dip:DIP-29429N	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:0tnO11U1SNOOT46j23f7dim8O8k10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:G5E8P0	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2554025|ensembl:ENSMUSP00000104977|intact:EBI-11600212|uniprotkb:Q6PFC6|uniprotkb:Q6ZPK3|uniprotkb:Q8BWI2	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp6_mouse(display_long)|uniprotkb:Tubgcp6(gene name)|psi-mi:Tubgcp6(display_short)|uniprotkb:Kiaa1669(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001156791.1|ensembl:ENSMUSG00000051786(gene)|ensembl:ENSMUST00000109353(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR042241|mint:G5E8P0|reactome:R-MMU-380270|reactome:R-MMU-380320|interpro:IPR041470	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:o8N6a4n0HmcfpjPF0YcWNZVH39c10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P58854	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2551135|ensembl:ENSMUSP00000000776|uniprotkb:Q6PDQ9	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp3_mouse(display_long)|uniprotkb:Gcp3(gene name synonym)|uniprotkb:Tubgcp3(gene name)|psi-mi:Tubgcp3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	reactome:R-MMU-380320|ensembl:ENSMUSG00000000759(gene)|ensembl:ENSMUST00000000776(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005827"(polar microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:P58854|reactome:R-MMU-380270|refseq:NP_932148.1	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:qyzJzan6HpBMaAAOyhPM+94ecQA10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q3UHB8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-16731180|ensembl:ENSMUSP00000072982|uniprotkb:Q6NXJ5	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:cc177_mouse(display_long)|uniprotkb:Ccdc177(gene name)|psi-mi:Ccdc177(display_short)|uniprotkb:Gm1568(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000062961(gene)|ensembl:ENSMUST00000073251(transcript)|interpro:IPR029090|mint:Q3UHB8|refseq:NP_001008423.2	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:objGQkpHL5Pr4FZHhKDHYGjAVUU10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P83887	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2553410|ensembl:ENSMUSP00000048036|uniprotkb:Q9Z310	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tbg1_mouse(display_long)|uniprotkb:Tubg1(gene name)|psi-mi:Tubg1(display_short)|uniprotkb:Tubg(gene name synonym)|uniprotkb:Gamma-1-tubulin(gene name synonym)|uniprotkb:Gamma-tubulin complex component 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000035198(gene)|ensembl:ENSMUST00000043680(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005827"(polar microtubule)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005929"(cilium)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0055037"(recycling endosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000217(Tubulin)|interpro:IPR002454(Gamma tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|go:"GO:0005525"(GTP binding)|interpro:IPR037103|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518|mint:P83887|refseq:NP_598785.1	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:vuOzSmoj6s4iR1pV9zNfwxYjue810090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9WV30	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472334|ensembl:ENSMUSP00000116094|uniprotkb:E9Q0P3|uniprotkb:E9Q6U2|uniprotkb:G5E8N9|uniprotkb:Q91WY0|uniprotkb:Q9JLA1	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:nfat5_mouse(display_long)|uniprotkb:Nfat5(gene name)|psi-mi:Nfat5(display_short)|uniprotkb:Rel domain-containing transcription factor NFAT5(gene name synonym)|uniprotkb:T-cell transcription factor NFAT5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000003847(gene)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0010628"(positive regulation of gene expression)|ensembl:ENSMUST00000125721(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|interpro:IPR011539(Rel homology)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0005634"(nucleus)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0005654"(nucleoplasm)|interpro:IPR015646(Nuclear factor of activated T-cells 5)|interpro:IPR032397|interpro:IPR037059|mint:Q9WV30|refseq:NP_001273189.1|refseq:NP_061293.2|refseq:NP_598718.2|refseq:XP_006531255.1|refseq:XP_017168393.1	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Yf1n8cmeTkVMCL5aw+LQZwrAIcM10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8BUR9	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2553237|ensembl:ENSMUSP00000037557	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mzt1_mouse(display_long)|uniprotkb:Mzt1(gene name)|psi-mi:Mzt1(display_short)|uniprotkb:Mozart1(gene name synonym)|uniprotkb:Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUST00000042662(transcript)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0033566"(gamma-tubulin complex localization)|go:"GO:0051415"(microtubule nucleation by interphase microtubule organizing center)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR022214|mint:Q8BUR9|reactome:R-MMU-380270|reactome:R-MMU-380320|ensembl:ENSMUSG00000033186(gene)|refseq:NP_780454.1	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:a686Bpxk37Kl0gKKTz14f6sq6s410090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q921G8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2552389|ensembl:ENSMUSP00000026547|uniprotkb:G5E859	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp2_mouse(display_long)|uniprotkb:Gcp2(gene name synonym)|uniprotkb:Tubgcp2(gene name)|psi-mi:Tubgcp2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001272936.1|ensembl:ENSMUSG00000025474(gene)|ensembl:ENSMUST00000026547(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0001764"(neuron migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007420"(brain development)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:Q921G8|reactome:R-MMU-380270|reactome:R-MMU-380320|go:"GO:0000923"(equatorial microtubule organizing center)|refseq:NP_598516.2	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:rWPzsdt3ECnxr+ksi4MaH7okQ+M10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P54071	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-773401|uniprotkb:Q8C2R9|uniprotkb:Q9EQK1|ensembl:ENSMUSP00000103007	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:idhp_mouse(display_long)|uniprotkb:Oxalosuccinate decarboxylase(gene name synonym)|uniprotkb:"NADP(+)-specific ICDH"(gene name synonym)|uniprotkb:IDP(gene name synonym)|uniprotkb:ICD-M(gene name synonym)|uniprotkb:Idh2(gene name)|psi-mi:Idh2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_766599.2|ensembl:ENSMUSG00000030541(gene)|ensembl:ENSMUST00000107384(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004448"(isocitrate dehydrogenase activity)|go:"GO:0004450"("isocitrate dehydrogenase (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0006741"(NADP biosynthetic process)|go:"GO:0051287"(NAD binding)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:1903976"(negative regulation of glial cell migration)|go:"GO:1904465"(negative regulation of matrix metallopeptidase secretion)|interpro:IPR004790(Isocitrate dehydrogenase NADP-dependent, eukaryotic)|interpro:IPR019818|interpro:IPR024084|mint:P54071|rcsb pdb:5H3E|rcsb pdb:5H3F|reactome:R-MMU-2151201|reactome:R-MMU-71403	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:CkBZHIePaNGTtcgyqEf03oczVM010090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q3UHD3	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472278|ensembl:ENSMUSP00000082694|uniprotkb:B9EKJ2|uniprotkb:Q7TPP7|uniprotkb:Q8CHD2|uniprotkb:Q9CY74	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mtus2_mouse(display_long)|uniprotkb:Mtus2(gene name)|psi-mi:Mtus2(display_short)|uniprotkb:Cazip(gene name synonym)|uniprotkb:Kiaa0774(gene name synonym)|uniprotkb:Tip150(gene name synonym)|uniprotkb:Cardiac zipper protein(gene name synonym)|uniprotkb:Microtubule plus-end tracking protein TIP150(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000029651(gene)|ensembl:ENSMUST00000085558(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR033339|mint:Q3UHD3|refseq:NP_084196.4|refseq:XP_006504953.1	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:42tgoThcDyvR8GE7irQd8rHlKL410090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P33215	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2366213|uniprotkb:Q6NXV3|uniprotkb:Q8BN12|uniprotkb:Q8BN86|uniprotkb:Q8BQL9|uniprotkb:Q9CWK2|ensembl:ENSMUSP00000020163	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:nedd1_mouse(display_long)|uniprotkb:Nedd1(gene name)|psi-mi:Nedd1(display_short)|uniprotkb:Nedd-1(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_032708.2|ensembl:ENSMUSG00000019988(gene)|ensembl:ENSMUST00000020163(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000922"(spindle pole)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0031109"(microtubule polymerization or depolymerization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045177"(apical part of cell)|go:"GO:0051301"(cell division)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P33215|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:xBFWC64fRlKEVonqdYWgcVEPK0010090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9QXL8	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-26472305	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:ndk7_mouse(display_long)|uniprotkb:Nme7(gene name)|psi-mi:Nme7(display_short)|uniprotkb:nm23-M7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	reactome:R-MMU-380320|go:"GO:0003351"(epithelial cilium movement involved in extracellular fluid movement)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005813"(centrosome)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0060830"(ciliary receptor clustering involved in smoothened signaling pathway)|go:"GO:0060972"(left/right pattern formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|reactome:R-MMU-380270|mint:Q9QXL8|interpro:IPR034907|interpro:IPR036850|interpro:IPR011410(Nucleoside diphosphate kinase, NDK7)|interpro:IPR035525|interpro:IPR037993|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR006602(Region of unknown function DM10)	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:zkOjHmuz7jAgTi/5/MQYROLtVKg10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P01027	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-4281083|uniprotkb:Q80XP1|ensembl:ENSMUSP00000024988|uniprotkb:Q61370	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:co3_mouse(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:HSE-MSF(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000024164(gene)|ensembl:ENSMUST00000024988(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008289"(lipid binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01027|rcsb pdb:6XZU|reactome:R-MMU-173736|reactome:R-MMU-174577|reactome:R-MMU-198933|reactome:R-MMU-375276|reactome:R-MMU-381426|reactome:R-MMU-418594|reactome:R-MMU-6798695|reactome:R-MMU-8957275|reactome:R-MMU-977606|refseq:NP_033908.2	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:VGFRYhKETrS9O7cyeJZyxBFgBL410090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P35441	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-6171593	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:tsp1_mouse(display_long)|uniprotkb:Thbs1(gene name)|psi-mi:Thbs1(display_short)|uniprotkb:Tsp1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0043236"(laminin binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|reactome:R-MMU-114608|reactome:R-MMU-186797|reactome:R-MMU-216083|reactome:R-MMU-5173214|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016477"(cell migration)|interpro:IPR001881(EGF-like calcium-binding)|mint:P35441|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR017897|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:0j9TPpvxNW9TNMFkFCNo+9wD3fA10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9CQ25	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-2552037|ensembl:ENSMUSP00000023351|ensembl:ENSMUSP00000113832	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mzt2_mouse(display_long)|uniprotkb:Fam128b(gene name synonym)|uniprotkb:Mozart2(gene name synonym)|uniprotkb:Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B(gene name synonym)|uniprotkb:Mzt2(gene name)|psi-mi:Mzt2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|interpro:IPR024332|ensembl:ENSMUSG00000022671(gene)|mint:Q9CQ25|reactome:R-MMU-380270|reactome:R-MMU-380320|ensembl:ENSMUST00000023351(transcript)|ensembl:ENSMUST00000117136(transcript)|refseq:NP_083630.1|refseq:XP_006522651.1	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:heL4NryOHurQ03jZtyHwM/D5Xe810090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:P11276	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-641955|uniprotkb:G5E8B8|uniprotkb:Q61567|uniprotkb:Q61568|uniprotkb:Q61569|uniprotkb:Q64233|uniprotkb:Q80UI4|ensembl:ENSMUSP00000054499	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:finc_mouse(display_long)|uniprotkb:Fn1(gene name)|psi-mi:Fn1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_034363.1|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P11276|rcsb pdb:1MFN|rcsb pdb:2MFN|reactome:R-MMU-114608|reactome:R-MMU-1474228|reactome:R-MMU-1474244|reactome:R-MMU-1566977|reactome:R-MMU-202733|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000170|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381426|reactome:R-MMU-5674135|reactome:R-MMU-8874081|reactome:R-MMU-8957275|ensembl:ENSMUSG00000026193(gene)|ensembl:ENSMUST00000055226(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005577"(fibrinogen complex)	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:qndGPG6vmzpIIkDuO1BrVRI1oPg10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q91VN4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-776230|uniprotkb:Q3UNQ1|uniprotkb:Q9D5I5|uniprotkb:Q9DAM8|ensembl:ENSMUSP00000032172	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mic25_mouse(display_long)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 6(gene name synonym)|uniprotkb:Mic25(gene name synonym)|uniprotkb:Chchd6(gene name)|psi-mi:Chchd6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_001161208.1|refseq:NP_079627.3|ensembl:ENSMUSG00000030086(gene)|ensembl:ENSMUST00000032172(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|interpro:IPR042860|mint:Q91VN4	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:Op64pUsaaQVJ4d+W9vkGMMkgI8810090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q8BKN5	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-11075667|uniprotkb:Q8C083|uniprotkb:Q69Z75|uniprotkb:Q8BLJ9|uniprotkb:Q3U8X5|ensembl:ENSMUSP00000032627	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:gcp5_mouse(display_long)|uniprotkb:Tubgcp5(gene name)|psi-mi:Tubgcp5(display_short)|uniprotkb:Kiaa1899(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:NP_666302.2|ensembl:ENSMUSG00000033790(gene)|ensembl:ENSMUST00000032627(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008017"(microtubule binding)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|interpro:IPR042241|mint:Q8BKN5|reactome:R-MMU-380270|reactome:R-MMU-380320	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:1BOIJxOyERW8OOgl7YGHj9W2PMw10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z2V6	uniprotkb:Q9CQR4	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-299825|ensembl:ENSMUSP00000006900	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:aco13_mouse(display_long)|uniprotkb:Acot13(gene name)|psi-mi:Acot13(display_short)|uniprotkb:Hotdog-fold thioesterase superfamily member 2(gene name synonym)|uniprotkb:Palmitoyl-CoA hydrolase(gene name synonym)|uniprotkb:Them2(gene name synonym)|uniprotkb:Thioesterase superfamily member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26473979|imex:IM-28526-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	ensembl:ENSMUSG00000006717(gene)|ensembl:ENSMUST00000006900(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR003736(Phenylacetic acid degradation-related protein)|interpro:IPR006683(Thioesterase superfamily)|interpro:IPR029069|interpro:IPR039298|mint:Q9CQR4|rcsb pdb:2CY9|reactome:R-MMU-77289|refseq:NP_080066.1	-	-	-	figure legend:ST5|comment:For Hdac5 isolations in the striatum, we again used a uniform cutoff of 0.7 in all conditions.|comment:"Q140 mice, 10 months old were used for this experiment.    \"the Q20 mouse was used as a “normal” condition, as this repeat length represents a non-disease causing polyQ repeat, and the Q140 mouse represented an HD disease condition.\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-striatum)|taxid:10090(Mus musculus, striatum)	-	2020/11/24	2020/11/26	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:jMok2ZPtX2ETleMlnA+90d/FVxs10090	rigid:veHi2dlI/3HfefGtvxDKEzbWBpk	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q3UHD6	uniprotkb:P56524	intact:EBI-6910393|ensembl:ENSMUSP00000102904|uniprotkb:Q7TQL6|uniprotkb:Q80TZ1|uniprotkb:Q9CYB5	intact:EBI-308629|uniprotkb:Q9UND6|uniprotkb:E9PGB9|uniprotkb:F5GX36|uniprotkb:Q86YH7|intact:EBI-28970476|ensembl:ENSP00000264606	psi-mi:snx27_mouse(display_long)|uniprotkb:Snx27(gene name)|psi-mi:Snx27(display_short)|uniprotkb:Kiaa0488(gene name synonym)	psi-mi:hdac4_human(display_long)|uniprotkb:HDAC4(gene name)|psi-mi:HDAC4(display_short)|uniprotkb:KIAA0288(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26474054|imex:IM-28526-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006886"(intracellular protein transport)|go:"GO:0007165"(signal transduction)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016197"(endosomal transport)|go:"GO:0030904"(retromer complex)|ensembl:ENSMUSG00000028136(gene)|ensembl:ENSMUST00000107283(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0071203"(WASH complex)|go:"GO:0005768"(endosome)|go:"GO:0099638"(endosome to plasma membrane protein transport)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|interpro:IPR000159(Ras-association)|interpro:IPR001478(PDZ/DHR/GLGF)|go:"GO:0005769"(early endosome)|interpro:IPR001683(Phox-like)|interpro:IPR028667|interpro:IPR029071|go:"GO:0005829"(cytosol)|interpro:IPR036034|go:"GO:0005886"(plasma membrane)|interpro:IPR036871|interpro:IPR037827|interpro:IPR037831|interpro:IPR037833|interpro:IPR037835|mint:Q3UHD6|refseq:NP_001075953.1|refseq:NP_083997.1|dip:DIP-60337N	ensembl:ENSP00000264606|ensembl:ENSG00000068024(gene)|ensembl:ENST00000345617(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:P56524|rcsb pdb:2H8N|rcsb pdb:2O94|rcsb pdb:2VQJ|rcsb pdb:2VQM|rcsb pdb:2VQO|rcsb pdb:2VQQ|rcsb pdb:2VQV|rcsb pdb:2VQW|rcsb pdb:3UXG|rcsb pdb:3UZD|rcsb pdb:3V31|rcsb pdb:4CBT|rcsb pdb:4CBY|rcsb pdb:5A2S|rcsb pdb:5ZOO|rcsb pdb:5ZOP|rcsb pdb:6FYZ|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-8941284|reactome:R-HSA-8951936|refseq:NP_006028.2|dip:DIP-34565N	-	-	-	figure legend:F6C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/11/24	2020/11/26	rogid:+pFe87lSKQPJuMDWsiMU4iXhGOw10090	rogid:EJhE8LikofmF9H8ubNsola4pSpc9606	rigid:tJjgIA3Ekf7NE+B0w1UlhcdrGg8	false	flag tag:?-?	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y4E1	uniprotkb:P56524	intact:EBI-948957|intact:EBI-28970026|ensembl:ENSP00000363482|uniprotkb:Q5SQU4|uniprotkb:Q5SQU5|uniprotkb:Q7L521|uniprotkb:Q9UG79|intact:EBI-2563814|uniprotkb:B4DZQ6|uniprotkb:B9EK53|uniprotkb:F5H0J6|uniprotkb:F5H871	intact:EBI-308629|uniprotkb:Q9UND6|uniprotkb:E9PGB9|uniprotkb:F5GX36|uniprotkb:Q86YH7|intact:EBI-28970476|ensembl:ENSP00000264606	psi-mi:wac2c_human(display_long)|uniprotkb:VPEF(gene name synonym)|uniprotkb:WASHC2C(gene name)|psi-mi:WASHC2C(display_short)|uniprotkb:FAM21C(gene name synonym)|uniprotkb:KIAA0592(gene name synonym)|uniprotkb:Vaccinia virus penetration factor(gene name synonym)	psi-mi:hdac4_human(display_long)|uniprotkb:HDAC4(gene name)|psi-mi:HDAC4(display_short)|uniprotkb:KIAA0288(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26474076|imex:IM-28526-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000172661(gene)|ensembl:ENST00000374362(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0015031"(protein transport)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071203"(WASH complex)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:1905394"(retromer complex binding)|go:"GO:2000813"(negative regulation of barbed-end actin filament capping)|interpro:IPR029341|mint:Q9Y4E1|ensembl:ENST00000540872|ensembl:ENSP00000439811|ensembl:ENSP00000363482|ensembl:ENST00000537517|ensembl:ENSP00000442128|refseq:NP_001162577.1|refseq:NP_001162578.1|refseq:NP_056077.2	ensembl:ENSP00000264606|ensembl:ENSG00000068024(gene)|ensembl:ENST00000345617(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:P56524|rcsb pdb:2H8N|rcsb pdb:2O94|rcsb pdb:2VQJ|rcsb pdb:2VQM|rcsb pdb:2VQO|rcsb pdb:2VQQ|rcsb pdb:2VQV|rcsb pdb:2VQW|rcsb pdb:3UXG|rcsb pdb:3UZD|rcsb pdb:3V31|rcsb pdb:4CBT|rcsb pdb:4CBY|rcsb pdb:5A2S|rcsb pdb:5ZOO|rcsb pdb:5ZOP|rcsb pdb:6FYZ|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-8941284|reactome:R-HSA-8951936|refseq:NP_006028.2|dip:DIP-34565N	-	-	-	figure legend:F6C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/11/24	2020/11/26	rogid:gUK2aPVIQiHey/Wka1mgFuBTKNE9606	rogid:EJhE8LikofmF9H8ubNsola4pSpc9606	rigid:pxPq7CMKn6r2wirt68/JkcQMajY	false	flag tag:?-?|sufficient binding region:1-220	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9CR27	uniprotkb:P56524	intact:EBI-11566651|uniprotkb:Q8K2X5|uniprotkb:Q9D0Y7|ensembl:ENSMUSP00000020248	intact:EBI-308629|uniprotkb:Q9UND6|uniprotkb:E9PGB9|uniprotkb:F5GX36|uniprotkb:Q86YH7|intact:EBI-28970476|ensembl:ENSP00000264606	psi-mi:wasc3_mouse(display_long)|uniprotkb:Washc3(gene name)|psi-mi:Washc3(display_short)|uniprotkb:Ccdc53(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 53(gene name synonym)	psi-mi:hdac4_human(display_long)|uniprotkb:HDAC4(gene name)|psi-mi:HDAC4(display_short)|uniprotkb:KIAA0288(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Federspiel et al. (2019)	imex:IM-28526|pubmed:31040226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26474087|imex:IM-28526-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116432.1|refseq:NP_080346.1|refseq:NP_081763.1|ensembl:ENSMUSG00000020056(gene)|ensembl:ENSMUST00000020248(transcript)|go:"GO:0005769"(early endosome)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0071203"(WASH complex)|interpro:IPR019309|mint:Q9CR27	ensembl:ENSP00000264606|ensembl:ENSG00000068024(gene)|ensembl:ENST00000345617(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:P56524|rcsb pdb:2H8N|rcsb pdb:2O94|rcsb pdb:2VQJ|rcsb pdb:2VQM|rcsb pdb:2VQO|rcsb pdb:2VQQ|rcsb pdb:2VQV|rcsb pdb:2VQW|rcsb pdb:3UXG|rcsb pdb:3UZD|rcsb pdb:3V31|rcsb pdb:4CBT|rcsb pdb:4CBY|rcsb pdb:5A2S|rcsb pdb:5ZOO|rcsb pdb:5ZOP|rcsb pdb:6FYZ|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-8941284|reactome:R-HSA-8951936|refseq:NP_006028.2|dip:DIP-34565N	-	-	-	figure legend:F6C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/11/24	2020/11/26	rogid:TIHhOD17V73KUaS7OofYZCe5z0k10090	rogid:EJhE8LikofmF9H8ubNsola4pSpc9606	rigid:iheqNJf7ZU9v3pOrgFol0gIpVzk	false	flag tag:?-?	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)