#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P27918	uniprotkb:P20160	intact:EBI-9038570|uniprotkb:O15134|uniprotkb:O15135|uniprotkb:O15136|uniprotkb:O75826|ensembl:ENSP00000247153|ensembl:ENSP00000380189	intact:EBI-2117388|uniprotkb:P80014|uniprotkb:Q52LG4|uniprotkb:Q9UCM1|uniprotkb:Q9UCT5|ensembl:ENSP00000233997|ensembl:ENSP00000479183	psi-mi:prop_human(display_long)|uniprotkb:CFP(gene name)|psi-mi:CFP(display_short)|uniprotkb:PFC(gene name synonym)|uniprotkb:Complement factor P(gene name synonym)	psi-mi:cap7_human(display_long)|uniprotkb:AZU1(gene name)|psi-mi:AZU1(display_short)|uniprotkb:Cationic antimicrobial protein CAP37(gene name synonym)|uniprotkb:Heparin-binding protein(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	O'Flynn et al. (2013)	pubmed:24355864|imex:IM-27336	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21995353|imex:IM-27336-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138724.1|refseq:NP_002612.1|ensembl:ENSG00000126759(gene)|ensembl:ENST00000247153(transcript)|ensembl:ENST00000396992(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006955"(immune response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR036383|rcsb pdb:1W0R|rcsb pdb:1W0S|rcsb pdb:6RUR|rcsb pdb:6RUS|rcsb pdb:6RUV|rcsb pdb:6RV6|rcsb pdb:6S08|rcsb pdb:6S0A|rcsb pdb:6S0B|rcsb pdb:6SEJ|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-5083635|reactome:R-HSA-5173214|reactome:R-HSA-6798695|reactome:R-HSA-977606	refseq:NP_001691.1|ensembl:ENSG00000172232(gene)|ensembl:ENSG00000278624(gene)|ensembl:ENST00000233997(transcript)|ensembl:ENST00000620695(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008347"(glial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0019730"(antimicrobial humoral response)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042117"(monocyte activation)|go:"GO:0042582"(azurophil granule)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051607"(defense response to virus)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|mint:P20160|rcsb pdb:1A7S|rcsb pdb:1AE5|rcsb pdb:1FY1|rcsb pdb:1FY3|reactome:R-HSA-6798695	-	-	-	figure legend:2A-1|comment:very weak interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/04	rogid:XBExMxbnkfjvnV9zHMRZgxZWKaw9606	rogid:NjuqhpdZ8a3hFlbxQSMNTQbxkgA9606	rigid:zb0OPcnXP9NBRhc38XHGrK9u9vE	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P27918	uniprotkb:P24158	intact:EBI-9038570|uniprotkb:O15134|uniprotkb:O15135|uniprotkb:O15136|uniprotkb:O75826|ensembl:ENSP00000247153|ensembl:ENSP00000380189	intact:EBI-465028|uniprotkb:Q9UQD8|ensembl:ENSP00000234347|ensembl:ENSP00000478977|uniprotkb:P15637|uniprotkb:P18078|uniprotkb:Q4VB09|uniprotkb:Q6LBM7|uniprotkb:Q4VB08|uniprotkb:Q6LBN2|uniprotkb:Q9UD25	psi-mi:prop_human(display_long)|uniprotkb:CFP(gene name)|psi-mi:CFP(display_short)|uniprotkb:PFC(gene name synonym)|uniprotkb:Complement factor P(gene name synonym)	psi-mi:prtn3_human(display_long)|uniprotkb:MBN(gene name synonym)|uniprotkb:PRTN3(gene name)|psi-mi:PRTN3(display_short)|uniprotkb:Leukocyte proteinase 3(gene name synonym)|uniprotkb:AGP7(gene name synonym)|uniprotkb:Wegener autoantigen(gene name synonym)|uniprotkb:P29(gene name synonym)|uniprotkb:C-ANCA antigen(gene name synonym)|uniprotkb:Neutrophil proteinase 4(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	O'Flynn et al. (2013)	pubmed:24355864|imex:IM-27336	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21995362|imex:IM-27336-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138724.1|refseq:NP_002612.1|ensembl:ENSG00000126759(gene)|ensembl:ENST00000247153(transcript)|ensembl:ENST00000396992(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006955"(immune response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR036383|rcsb pdb:1W0R|rcsb pdb:1W0S|rcsb pdb:6RUR|rcsb pdb:6RUS|rcsb pdb:6RUV|rcsb pdb:6RV6|rcsb pdb:6S08|rcsb pdb:6S0A|rcsb pdb:6S0B|rcsb pdb:6SEJ|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-5083635|reactome:R-HSA-5173214|reactome:R-HSA-6798695|reactome:R-HSA-977606	ensembl:ENSG00000196415(gene)|ensembl:ENSG00000277804(gene)|ensembl:ENST00000234347(transcript)|ensembl:ENST00000612112(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019730"(antimicrobial humoral response)|go:"GO:0019899"(enzyme binding)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0097029"(mature conventional dendritic cell differentiation)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|mint:P24158|rcsb pdb:1FUJ|reactome:R-HSA-140875|reactome:R-HSA-449836|reactome:R-HSA-6798695|reactome:R-HSA-6803157|interpro:IPR001314(Peptidase S1A, chymotrypsin)|refseq:NP_002768.3|dip:DIP-31107N	-	-	-	figure legend:2A-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/04	rogid:XBExMxbnkfjvnV9zHMRZgxZWKaw9606	rogid:+28oFrY+yAY4MtIR0vfAfItyhrM9606	rigid:EuNrmZtmAPYZKaLt5GBDK/pK+0g	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P27918	uniprotkb:P61626	intact:EBI-9038570|uniprotkb:O15134|uniprotkb:O15135|uniprotkb:O15136|uniprotkb:O75826|ensembl:ENSP00000247153|ensembl:ENSP00000380189	intact:EBI-355360|ensembl:ENSP00000261267|uniprotkb:P00695|uniprotkb:Q9UCF8|uniprotkb:Q13170	psi-mi:prop_human(display_long)|uniprotkb:CFP(gene name)|psi-mi:CFP(display_short)|uniprotkb:PFC(gene name synonym)|uniprotkb:Complement factor P(gene name synonym)	psi-mi:lysc_human(display_long)|uniprotkb:LYZ(gene name)|psi-mi:LYZ(display_short)|uniprotkb:LZM(gene name synonym)|uniprotkb:1,4-beta-N-acetylmuramidase C(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	O'Flynn et al. (2013)	pubmed:24355864|imex:IM-27336	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21995375|imex:IM-27336-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138724.1|refseq:NP_002612.1|ensembl:ENSG00000126759(gene)|ensembl:ENST00000247153(transcript)|ensembl:ENST00000396992(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006955"(immune response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR036383|rcsb pdb:1W0R|rcsb pdb:1W0S|rcsb pdb:6RUR|rcsb pdb:6RUS|rcsb pdb:6RUV|rcsb pdb:6RV6|rcsb pdb:6S08|rcsb pdb:6S0A|rcsb pdb:6S0B|rcsb pdb:6SEJ|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-5083635|reactome:R-HSA-5173214|reactome:R-HSA-6798695|reactome:R-HSA-977606	ensembl:ENSG00000090382(gene)|refseq:NP_000230.1|rcsb pdb:1GB7|rcsb pdb:1GB8|rcsb pdb:1GB9|rcsb pdb:1GBO|rcsb pdb:1GBW|rcsb pdb:1GBX|rcsb pdb:1GBY|rcsb pdb:1GBZ|rcsb pdb:1GDW|rcsb pdb:1GDX|rcsb pdb:1GE0|rcsb pdb:1GE1|rcsb pdb:1GE2|rcsb pdb:1GE3|rcsb pdb:1GE4|rcsb pdb:1GEV|rcsb pdb:1GEZ|rcsb pdb:1GF0|rcsb pdb:1GF3|rcsb pdb:1GF4|rcsb pdb:1GF5|rcsb pdb:1GF6|rcsb pdb:1GF7|rcsb pdb:1GF8|rcsb pdb:1GF9|rcsb pdb:1GFA|rcsb pdb:1GFE|rcsb pdb:1GFG|rcsb pdb:1GFH|rcsb pdb:1GFJ|rcsb pdb:1GFK|rcsb pdb:1GFR|rcsb pdb:1GFT|rcsb pdb:1GFU|rcsb pdb:1GFV|rcsb pdb:1HNL|rcsb pdb:1I1Z|rcsb pdb:1I20|rcsb pdb:1I22|rcsb pdb:1INU|rcsb pdb:1IOC|rcsb pdb:1IP1|rcsb pdb:1IP2|rcsb pdb:1IP3|rcsb pdb:1IP4|rcsb pdb:1IP5|rcsb pdb:1IP6|rcsb pdb:1IP7|rcsb pdb:1IWT|rcsb pdb:1IWU|rcsb pdb:1IWV|rcsb pdb:1IWW|rcsb pdb:1IWX|rcsb pdb:1IWY|rcsb pdb:1IWZ|rcsb pdb:1IX0|rcsb pdb:1IY3|rcsb pdb:1IY4|rcsb pdb:1JKA|rcsb pdb:1JKB|rcsb pdb:1JKC|rcsb pdb:1JKD|rcsb pdb:1JSF|rcsb pdb:1JWR|rcsb pdb:1LAA|rcsb pdb:1LHH|rcsb pdb:1LHI|rcsb pdb:1LHJ|rcsb pdb:1LHK|rcsb pdb:1LHL|rcsb pdb:1LHM|rcsb pdb:1LMT|rcsb pdb:1LOZ|rcsb pdb:1LYY|rcsb pdb:1LZ1|rcsb pdb:1LZ4|rcsb pdb:1LZ5|rcsb pdb:1LZ6|rcsb pdb:1LZR|rcsb pdb:1LZS|rcsb pdb:1OP9|rcsb pdb:1OUA|rcsb pdb:1OUB|rcsb pdb:1OUC|rcsb pdb:1OUD|rcsb pdb:1OUE|rcsb pdb:1OUF|rcsb pdb:1OUG|rcsb pdb:1OUH|rcsb pdb:1OUI|rcsb pdb:1OUJ|rcsb pdb:1QSW|rcsb pdb:1RE2|rcsb pdb:1REM|rcsb pdb:1REX|rcsb pdb:1REY|rcsb pdb:1REZ|rcsb pdb:1TAY|rcsb pdb:1TBY|rcsb pdb:1TCY|rcsb pdb:1TDY|rcsb pdb:1UBZ|rcsb pdb:5LVK|rcsb pdb:6LFH|reactome:R-HSA-6798695|reactome:R-HSA-6803157|reactome:R-HSA-977225|rcsb pdb:1W08|rcsb pdb:1WQM|rcsb pdb:1WQN|rcsb pdb:1WQO|rcsb pdb:1WQP|rcsb pdb:1WQQ|rcsb pdb:1WQR|rcsb pdb:1YAM|rcsb pdb:1YAN|rcsb pdb:1YAO|rcsb pdb:1YAP|rcsb pdb:1YAQ|rcsb pdb:207L|rcsb pdb:208L|rcsb pdb:2BQA|rcsb pdb:2BQB|rcsb pdb:2BQC|rcsb pdb:2BQD|rcsb pdb:2BQE|rcsb pdb:2BQF|rcsb pdb:2BQG|rcsb pdb:2BQH|rcsb pdb:2BQI|rcsb pdb:2BQJ|rcsb pdb:2BQK|rcsb pdb:2BQL|rcsb pdb:2BQM|rcsb pdb:2BQN|rcsb pdb:2BQO|rcsb pdb:2HEA|rcsb pdb:2HEB|rcsb pdb:2HEC|rcsb pdb:2HED|rcsb pdb:2HEE|rcsb pdb:2HEF|rcsb pdb:2LHM|rcsb pdb:2MEA|rcsb pdb:2MEB|rcsb pdb:2MEC|rcsb pdb:2MED|rcsb pdb:2MEE|rcsb pdb:2MEF|rcsb pdb:2MEG|rcsb pdb:2MEH|rcsb pdb:2MEI|rcsb pdb:2NWD|rcsb pdb:2ZIJ|rcsb pdb:2ZIK|rcsb pdb:2ZIL|rcsb pdb:2ZWB|rcsb pdb:3EBA|rcsb pdb:3FE0|rcsb pdb:3LHM|rcsb pdb:3LN2|rcsb pdb:4I0C|rcsb pdb:4ML7|rcsb pdb:4R0P|rcsb pdb:5LSH|rcsb pdb:1B5X|rcsb pdb:1B5Y|rcsb pdb:1B5Z|rcsb pdb:1B7L|rcsb pdb:1B7M|rcsb pdb:1B7N|rcsb pdb:1B7O|rcsb pdb:1B7P|rcsb pdb:1B7Q|rcsb pdb:1B7R|rcsb pdb:1B7S|rcsb pdb:1BB3|rcsb pdb:1BB4|rcsb pdb:1BB5|rcsb pdb:1C43|rcsb pdb:1C45|rcsb pdb:1C46|rcsb pdb:1C7P|rcsb pdb:1CJ6|rcsb pdb:1CJ7|rcsb pdb:1CJ8|ensembl:ENST00000261267(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003796"(lysozyme activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008152"(metabolic process)|go:"GO:0019730"(antimicrobial humoral response)|go:"GO:0019835"(cytolysis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000974(Glycoside hydrolase, family 22, lysozyme)|interpro:IPR001916(Glycoside hydrolase, family 22)|interpro:IPR019799|interpro:IPR023346|interpro:IPR030056|mint:P61626|rcsb pdb:133L|rcsb pdb:134L|rcsb pdb:1B5U|rcsb pdb:1B5V|rcsb pdb:1B5W|rcsb pdb:1CJ9|rcsb pdb:1CKC|rcsb pdb:1CKD|rcsb pdb:1CKF|rcsb pdb:1CKG|rcsb pdb:1CKH|rcsb pdb:1D6P|rcsb pdb:1D6Q|rcsb pdb:1DI3|rcsb pdb:1DI4|rcsb pdb:1DI5|rcsb pdb:1EQ4|rcsb pdb:1EQ5|rcsb pdb:1EQE|rcsb pdb:1GAY|rcsb pdb:1GAZ|rcsb pdb:1GB0|rcsb pdb:1GB2|rcsb pdb:1GB3|rcsb pdb:1GB5|rcsb pdb:1GB6	-	-	-	figure legend:2A-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/04	rogid:XBExMxbnkfjvnV9zHMRZgxZWKaw9606	rogid:jydNN9yuU9EYvnth+kv115svRxw9606	rigid:yZIssOQmpTmL3l4LJcC3xVs/TA4	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P27918	uniprotkb:P08311	intact:EBI-9038570|uniprotkb:O15134|uniprotkb:O15135|uniprotkb:O15136|uniprotkb:O75826|ensembl:ENSP00000247153|ensembl:ENSP00000380189	intact:EBI-5462635|uniprotkb:Q6IBJ6|uniprotkb:Q9UCA5|uniprotkb:Q9UCU6|ensembl:ENSP00000216336	psi-mi:prop_human(display_long)|uniprotkb:CFP(gene name)|psi-mi:CFP(display_short)|uniprotkb:PFC(gene name synonym)|uniprotkb:Complement factor P(gene name synonym)	psi-mi:catg_human(display_long)|uniprotkb:CTSG(gene name)|psi-mi:CTSG(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	O'Flynn et al. (2013)	pubmed:24355864|imex:IM-27336	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21995381|imex:IM-27336-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138724.1|refseq:NP_002612.1|ensembl:ENSG00000126759(gene)|ensembl:ENST00000247153(transcript)|ensembl:ENST00000396992(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006955"(immune response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR036383|rcsb pdb:1W0R|rcsb pdb:1W0S|rcsb pdb:6RUR|rcsb pdb:6RUS|rcsb pdb:6RUV|rcsb pdb:6RV6|rcsb pdb:6S08|rcsb pdb:6S0A|rcsb pdb:6S0B|rcsb pdb:6SEJ|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-5083635|reactome:R-HSA-5173214|reactome:R-HSA-6798695|reactome:R-HSA-977606	refseq:NP_001902.1|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035590"(purinergic nucleotide receptor signaling pathway)|ensembl:ENSG00000100448(gene)|ensembl:ENST00000216336(transcript)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006508"(proteolysis)|go:"GO:0006955"(immune response)|go:"GO:0008201"(heparin binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050832"(defense response to fungus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070946"(neutrophil-mediated killing of gram-positive bacterium)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|mint:P08311|rcsb pdb:1AU8|reactome:R-HSA-448706|rcsb pdb:1CGH|rcsb pdb:1KYN|rcsb pdb:1T32|rcsb pdb:6VTM|reactome:R-HSA-6798695|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-2022377|reactome:R-HSA-381426|reactome:R-HSA-6803157|reactome:R-HSA-9635465|reactome:R-HSA-9660826	-	-	-	figure legend:2A-4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/04	rogid:XBExMxbnkfjvnV9zHMRZgxZWKaw9606	rogid:Q3qTg9KcvP4oI+A/QOUqk7ahWMU9606	rigid:+8VG361vK1nvFDq9peokhTGa5GQ	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P27918	uniprotkb:P05164	intact:EBI-9038570|uniprotkb:O15134|uniprotkb:O15135|uniprotkb:O15136|uniprotkb:O75826|ensembl:ENSP00000247153|ensembl:ENSP00000380189	intact:EBI-2556173|uniprotkb:Q14862|uniprotkb:Q9UCL7|uniprotkb:A1L4B8|uniprotkb:Q4PJH5|ensembl:ENSP00000225275	psi-mi:prop_human(display_long)|uniprotkb:CFP(gene name)|psi-mi:CFP(display_short)|uniprotkb:PFC(gene name synonym)|uniprotkb:Complement factor P(gene name synonym)	psi-mi:perm_human(display_long)|uniprotkb:MPO(gene name)|psi-mi:MPO(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	O'Flynn et al. (2013)	pubmed:24355864|imex:IM-27336	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21995385|imex:IM-27336-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138724.1|refseq:NP_002612.1|ensembl:ENSG00000126759(gene)|ensembl:ENST00000247153(transcript)|ensembl:ENST00000396992(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006955"(immune response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR036383|rcsb pdb:1W0R|rcsb pdb:1W0S|rcsb pdb:6RUR|rcsb pdb:6RUS|rcsb pdb:6RUV|rcsb pdb:6RV6|rcsb pdb:6S08|rcsb pdb:6S0A|rcsb pdb:6S0B|rcsb pdb:6SEJ|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-5083635|reactome:R-HSA-5173214|reactome:R-HSA-6798695|reactome:R-HSA-977606	refseq:NP_000241.1|ensembl:ENSG00000005381(gene)|go:"GO:0002149"(hypochlorous acid biosynthetic process)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003682"(chromatin binding)|ensembl:ENST00000225275(transcript)|go:"GO:0001878"(response to yeast)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006952"(defense response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0032094"(response to food)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042582"(azurophil granule)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1990268"(response to gold nanoparticle)|interpro:IPR010255(Haem peroxidase)|interpro:IPR019791|interpro:IPR029609|interpro:IPR037120|mint:P05164|rcsb pdb:1CXP|rcsb pdb:1D2V|rcsb pdb:1D5L|rcsb pdb:1D7W|rcsb pdb:1DNU|rcsb pdb:1DNW|rcsb pdb:1MHL|rcsb pdb:1MYP|rcsb pdb:3F9P|rcsb pdb:3ZS0|rcsb pdb:3ZS1|rcsb pdb:4C1M|rcsb pdb:4DL1|rcsb pdb:4EJX|rcsb pdb:5FIW|rcsb pdb:5MFA|rcsb pdb:5UZU|rcsb pdb:6AZP|rcsb pdb:6BMT|reactome:R-HSA-6798695|reactome:R-HSA-8941413	-	-	-	figure legend:2A,3,5A|agonist:Buffer containing magnesium salt of EGTA.|antagonist:Buffer containing EDTA.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/04	rogid:XBExMxbnkfjvnV9zHMRZgxZWKaw9606	rogid:SNoAXb3csr/iOyGWeyWcUyJTZLY9606	rigid:kjFBefF7X2CLYQPq3rWIwuoEdVw	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P27918	uniprotkb:P08246	intact:EBI-9038570|uniprotkb:O15134|uniprotkb:O15135|uniprotkb:O15136|uniprotkb:O75826|ensembl:ENSP00000247153|ensembl:ENSP00000380189	intact:EBI-986345|uniprotkb:P09649|uniprotkb:Q6B0D9|uniprotkb:Q6LDP5|ensembl:ENSP00000263621|ensembl:ENSP00000466090|ensembl:ENSP00000480128|ensembl:ENSP00000488075	psi-mi:prop_human(display_long)|uniprotkb:CFP(gene name)|psi-mi:CFP(display_short)|uniprotkb:PFC(gene name synonym)|uniprotkb:Complement factor P(gene name synonym)	psi-mi:elne_human(display_long)|uniprotkb:Elastase-2(gene name synonym)|uniprotkb:ELANE(gene name)|psi-mi:ELANE(display_short)|uniprotkb:PMN elastase(gene name synonym)|uniprotkb:Bone marrow serine protease(gene name synonym)|uniprotkb:Medullasin(gene name synonym)|uniprotkb:Human leukocyte elastase(gene name synonym)|uniprotkb:ELA2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	O'Flynn et al. (2013)	pubmed:24355864|imex:IM-27336	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21995391|imex:IM-27336-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138724.1|refseq:NP_002612.1|ensembl:ENSG00000126759(gene)|ensembl:ENST00000247153(transcript)|ensembl:ENST00000396992(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006955"(immune response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR036383|rcsb pdb:1W0R|rcsb pdb:1W0S|rcsb pdb:6RUR|rcsb pdb:6RUS|rcsb pdb:6RUV|rcsb pdb:6RV6|rcsb pdb:6S08|rcsb pdb:6S0A|rcsb pdb:6S0B|rcsb pdb:6SEJ|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-5083635|reactome:R-HSA-5173214|reactome:R-HSA-6798695|reactome:R-HSA-977606	ensembl:ENSG00000197561(gene)|ensembl:ENSG00000277571(gene)|ensembl:ENST00000263621(transcript)|ensembl:ENST00000590230(transcript)|ensembl:ENST00000615489(transcript)|ensembl:ENST00000632488(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001878"(response to yeast)|go:"GO:0002020"(protease binding)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002812"(biosynthetic process of antibacterial peptides active against Gram-negative bacteria)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008201"(heparin binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0009986"(cell surface)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019955"(cytokine binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030163"(protein catabolic process)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0050922"(negative regulation of chemotaxis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070269"(pyroptosis)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0070947"(neutrophil-mediated killing of fungus)|go:"GO:1903238"(positive regulation of leukocyte tethering or rolling)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|mint:P08246|rcsb pdb:1B0F|rcsb pdb:1H1B|rcsb pdb:1HNE|rcsb pdb:1PPF|rcsb pdb:1PPG|rcsb pdb:2RG3|rcsb pdb:2Z7F|rcsb pdb:3Q76|rcsb pdb:3Q77|rcsb pdb:4NZL|rcsb pdb:4WVP|rcsb pdb:5A09|rcsb pdb:5A0A|rcsb pdb:5A0B|rcsb pdb:5A0C|rcsb pdb:5A8X|rcsb pdb:5A8Y|rcsb pdb:5A8Z|rcsb pdb:5ABW|rcsb pdb:6E69|rcsb pdb:6F5M|rcsb pdb:6SMA|rcsb pdb:7CBK|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-5620971|reactome:R-HSA-6798695|reactome:R-HSA-6803157|reactome:R-HSA-977606|refseq:NP_001963.1|refseq:XP_011526078.1|refseq:XP_011526077.1	-	-	-	figure legend:2A-6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/04	rogid:XBExMxbnkfjvnV9zHMRZgxZWKaw9606	rogid:0XCflWhF346d7Dy2+ENeMyDHPmA9606	rigid:jzdoHeRMtcHgYGAxvR0Gi89lUDE	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P05164	uniprotkb:P27918	intact:EBI-2556173|uniprotkb:Q14862|uniprotkb:Q9UCL7|uniprotkb:A1L4B8|uniprotkb:Q4PJH5|ensembl:ENSP00000225275	intact:EBI-9038570|uniprotkb:O15134|uniprotkb:O15135|uniprotkb:O15136|uniprotkb:O75826|ensembl:ENSP00000247153|ensembl:ENSP00000380189	psi-mi:perm_human(display_long)|uniprotkb:MPO(gene name)|psi-mi:MPO(display_short)	psi-mi:prop_human(display_long)|uniprotkb:CFP(gene name)|psi-mi:CFP(display_short)|uniprotkb:PFC(gene name synonym)|uniprotkb:Complement factor P(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	O'Flynn et al. (2013)	pubmed:24355864|imex:IM-27336	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21995395|imex:IM-27336-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000241.1|ensembl:ENSG00000005381(gene)|go:"GO:0002149"(hypochlorous acid biosynthetic process)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003682"(chromatin binding)|ensembl:ENST00000225275(transcript)|go:"GO:0001878"(response to yeast)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006952"(defense response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0032094"(response to food)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042582"(azurophil granule)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1990268"(response to gold nanoparticle)|interpro:IPR010255(Haem peroxidase)|interpro:IPR019791|interpro:IPR029609|interpro:IPR037120|mint:P05164|rcsb pdb:1CXP|rcsb pdb:1D2V|rcsb pdb:1D5L|rcsb pdb:1D7W|rcsb pdb:1DNU|rcsb pdb:1DNW|rcsb pdb:1MHL|rcsb pdb:1MYP|rcsb pdb:3F9P|rcsb pdb:3ZS0|rcsb pdb:3ZS1|rcsb pdb:4C1M|rcsb pdb:4DL1|rcsb pdb:4EJX|rcsb pdb:5FIW|rcsb pdb:5MFA|rcsb pdb:5UZU|rcsb pdb:6AZP|rcsb pdb:6BMT|reactome:R-HSA-6798695|reactome:R-HSA-8941413	refseq:NP_001138724.1|refseq:NP_002612.1|ensembl:ENSG00000126759(gene)|ensembl:ENST00000247153(transcript)|ensembl:ENST00000396992(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006955"(immune response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR036383|rcsb pdb:1W0R|rcsb pdb:1W0S|rcsb pdb:6RUR|rcsb pdb:6RUS|rcsb pdb:6RUV|rcsb pdb:6RV6|rcsb pdb:6S08|rcsb pdb:6S0A|rcsb pdb:6S0B|rcsb pdb:6SEJ|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-5083635|reactome:R-HSA-5173214|reactome:R-HSA-6798695|reactome:R-HSA-977606	-	-	-	figure legend:2B,4, 5B/C,6|agonist:Buffer containing magnesium salt of EGTA.|antagonist:Buffer containing EDTA.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/04	rogid:SNoAXb3csr/iOyGWeyWcUyJTZLY9606	rogid:XBExMxbnkfjvnV9zHMRZgxZWKaw9606	rigid:c3XcEXqKPTnO5bKqMlXVAqaXgLk	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P05164	uniprotkb:P01024	intact:EBI-2556173|uniprotkb:Q14862|uniprotkb:Q9UCL7|uniprotkb:A1L4B8|uniprotkb:Q4PJH5|ensembl:ENSP00000225275	intact:EBI-905851|uniprotkb:A7E236|ensembl:ENSP00000245907	psi-mi:perm_human(display_long)|uniprotkb:MPO(gene name)|psi-mi:MPO(display_short)	psi-mi:co3_human(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:CPAMD1(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	O'Flynn et al. (2013)	pubmed:24355864|imex:IM-27336	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21995395|imex:IM-27336-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000241.1|ensembl:ENSG00000005381(gene)|go:"GO:0002149"(hypochlorous acid biosynthetic process)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003682"(chromatin binding)|ensembl:ENST00000225275(transcript)|go:"GO:0001878"(response to yeast)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006952"(defense response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0032094"(response to food)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042582"(azurophil granule)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1990268"(response to gold nanoparticle)|interpro:IPR010255(Haem peroxidase)|interpro:IPR019791|interpro:IPR029609|interpro:IPR037120|mint:P05164|rcsb pdb:1CXP|rcsb pdb:1D2V|rcsb pdb:1D5L|rcsb pdb:1D7W|rcsb pdb:1DNU|rcsb pdb:1DNW|rcsb pdb:1MHL|rcsb pdb:1MYP|rcsb pdb:3F9P|rcsb pdb:3ZS0|rcsb pdb:3ZS1|rcsb pdb:4C1M|rcsb pdb:4DL1|rcsb pdb:4EJX|rcsb pdb:5FIW|rcsb pdb:5MFA|rcsb pdb:5UZU|rcsb pdb:6AZP|rcsb pdb:6BMT|reactome:R-HSA-6798695|reactome:R-HSA-8941413	refseq:NP_000055.2|dip:DIP-35180N|ensembl:ENSG00000125730(gene)|ensembl:ENST00000245907(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01024|rcsb pdb:1C3D|rcsb pdb:1GHQ|rcsb pdb:1W2S|rcsb pdb:2A73|rcsb pdb:2A74|rcsb pdb:2GOX|rcsb pdb:2I07|rcsb pdb:2ICE|rcsb pdb:2ICF|rcsb pdb:2NOJ|rcsb pdb:2QKI|rcsb pdb:2WII|rcsb pdb:2WIN|rcsb pdb:2WY7|rcsb pdb:2WY8|rcsb pdb:2XQW|rcsb pdb:2XWB|rcsb pdb:2XWJ|rcsb pdb:3D5R|rcsb pdb:3D5S|rcsb pdb:3G6J|rcsb pdb:3L3O|rcsb pdb:3L5N|rcsb pdb:3NMS|rcsb pdb:3OED|rcsb pdb:3OHX|rcsb pdb:3OXU|rcsb pdb:3RJ3|rcsb pdb:3T4A|rcsb pdb:4HW5|rcsb pdb:4HWJ|rcsb pdb:4I6O|rcsb pdb:4M76|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5FO7|rcsb pdb:5FO8|rcsb pdb:5FO9|rcsb pdb:5FOA|rcsb pdb:5FOB|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:6EHG|rcsb pdb:6RMT|rcsb pdb:6RMU|rcsb pdb:6RUR|rcsb pdb:6RUV|rcsb pdb:6S0B|rcsb pdb:6YO6|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-198933|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9660826|reactome:R-HSA-977606	-	-	-	figure legend:2B,4, 5B/C,6|agonist:Buffer containing magnesium salt of EGTA.|antagonist:Buffer containing EDTA.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/04	rogid:SNoAXb3csr/iOyGWeyWcUyJTZLY9606	rogid:6Axa89cCPpUXFsLnd7sCurZzLYI9606	rigid:c3XcEXqKPTnO5bKqMlXVAqaXgLk	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P01024	uniprotkb:P08311	intact:EBI-905851|uniprotkb:A7E236|ensembl:ENSP00000245907	intact:EBI-5462635|uniprotkb:Q6IBJ6|uniprotkb:Q9UCA5|uniprotkb:Q9UCU6|ensembl:ENSP00000216336	psi-mi:co3_human(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:CPAMD1(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1(gene name synonym)	psi-mi:catg_human(display_long)|uniprotkb:CTSG(gene name)|psi-mi:CTSG(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	O'Flynn et al. (2013)	pubmed:24355864|imex:IM-27336	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21995399|imex:IM-27336-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000055.2|dip:DIP-35180N|ensembl:ENSG00000125730(gene)|ensembl:ENST00000245907(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01024|rcsb pdb:1C3D|rcsb pdb:1GHQ|rcsb pdb:1W2S|rcsb pdb:2A73|rcsb pdb:2A74|rcsb pdb:2GOX|rcsb pdb:2I07|rcsb pdb:2ICE|rcsb pdb:2ICF|rcsb pdb:2NOJ|rcsb pdb:2QKI|rcsb pdb:2WII|rcsb pdb:2WIN|rcsb pdb:2WY7|rcsb pdb:2WY8|rcsb pdb:2XQW|rcsb pdb:2XWB|rcsb pdb:2XWJ|rcsb pdb:3D5R|rcsb pdb:3D5S|rcsb pdb:3G6J|rcsb pdb:3L3O|rcsb pdb:3L5N|rcsb pdb:3NMS|rcsb pdb:3OED|rcsb pdb:3OHX|rcsb pdb:3OXU|rcsb pdb:3RJ3|rcsb pdb:3T4A|rcsb pdb:4HW5|rcsb pdb:4HWJ|rcsb pdb:4I6O|rcsb pdb:4M76|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5FO7|rcsb pdb:5FO8|rcsb pdb:5FO9|rcsb pdb:5FOA|rcsb pdb:5FOB|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:6EHG|rcsb pdb:6RMT|rcsb pdb:6RMU|rcsb pdb:6RUR|rcsb pdb:6RUV|rcsb pdb:6S0B|rcsb pdb:6YO6|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-198933|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9660826|reactome:R-HSA-977606	refseq:NP_001902.1|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035590"(purinergic nucleotide receptor signaling pathway)|ensembl:ENSG00000100448(gene)|ensembl:ENST00000216336(transcript)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006508"(proteolysis)|go:"GO:0006955"(immune response)|go:"GO:0008201"(heparin binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050832"(defense response to fungus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070946"(neutrophil-mediated killing of gram-positive bacterium)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|mint:P08311|rcsb pdb:1AU8|reactome:R-HSA-448706|rcsb pdb:1CGH|rcsb pdb:1KYN|rcsb pdb:1T32|rcsb pdb:6VTM|reactome:R-HSA-6798695|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-2022377|reactome:R-HSA-381426|reactome:R-HSA-6803157|reactome:R-HSA-9635465|reactome:R-HSA-9660826	-	-	-	figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/04	rogid:6Axa89cCPpUXFsLnd7sCurZzLYI9606	rogid:Q3qTg9KcvP4oI+A/QOUqk7ahWMU9606	rigid:bsGjcWGYm7eDxIl6co23V45VOrA	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P05164	uniprotkb:P27918	intact:EBI-2556173|uniprotkb:Q14862|uniprotkb:Q9UCL7|uniprotkb:A1L4B8|uniprotkb:Q4PJH5|ensembl:ENSP00000225275	intact:EBI-9038570|uniprotkb:O15134|uniprotkb:O15135|uniprotkb:O15136|uniprotkb:O75826|ensembl:ENSP00000247153|ensembl:ENSP00000380189	psi-mi:perm_human(display_long)|uniprotkb:MPO(gene name)|psi-mi:MPO(display_short)	psi-mi:prop_human(display_long)|uniprotkb:CFP(gene name)|psi-mi:CFP(display_short)|uniprotkb:PFC(gene name synonym)|uniprotkb:Complement factor P(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	O'Flynn et al. (2013)	pubmed:24355864|imex:IM-27336	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22014316|imex:IM-27336-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000241.1|ensembl:ENSG00000005381(gene)|go:"GO:0002149"(hypochlorous acid biosynthetic process)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003682"(chromatin binding)|ensembl:ENST00000225275(transcript)|go:"GO:0001878"(response to yeast)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006952"(defense response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0032094"(response to food)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042582"(azurophil granule)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1990268"(response to gold nanoparticle)|interpro:IPR010255(Haem peroxidase)|interpro:IPR019791|interpro:IPR029609|interpro:IPR037120|mint:P05164|rcsb pdb:1CXP|rcsb pdb:1D2V|rcsb pdb:1D5L|rcsb pdb:1D7W|rcsb pdb:1DNU|rcsb pdb:1DNW|rcsb pdb:1MHL|rcsb pdb:1MYP|rcsb pdb:3F9P|rcsb pdb:3ZS0|rcsb pdb:3ZS1|rcsb pdb:4C1M|rcsb pdb:4DL1|rcsb pdb:4EJX|rcsb pdb:5FIW|rcsb pdb:5MFA|rcsb pdb:5UZU|rcsb pdb:6AZP|rcsb pdb:6BMT|reactome:R-HSA-6798695|reactome:R-HSA-8941413	refseq:NP_001138724.1|refseq:NP_002612.1|ensembl:ENSG00000126759(gene)|ensembl:ENST00000247153(transcript)|ensembl:ENST00000396992(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006955"(immune response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR036383|rcsb pdb:1W0R|rcsb pdb:1W0S|rcsb pdb:6RUR|rcsb pdb:6RUS|rcsb pdb:6RUV|rcsb pdb:6RV6|rcsb pdb:6S08|rcsb pdb:6S0A|rcsb pdb:6S0B|rcsb pdb:6SEJ|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-5083635|reactome:R-HSA-5173214|reactome:R-HSA-6798695|reactome:R-HSA-977606	-	-	-	figure legend:7|agonist:Buffer containing magnesium salt of EGTA.|comment:Buffer containing EDTA.|comment:"The monoclonal antibody (clone AE-11) used to detect binding of C5b-9,  is directed against a neoepitope exposed on C9 when incorporated into the membrane attack complex (MAC) or terminal complement complex (TCC)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/04	rogid:SNoAXb3csr/iOyGWeyWcUyJTZLY9606	rogid:XBExMxbnkfjvnV9zHMRZgxZWKaw9606	rigid:C6xAodfIr6QAoqiC1qVa0sAVnrc	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P05164	uniprotkb:P02748	intact:EBI-2556173|uniprotkb:Q14862|uniprotkb:Q9UCL7|uniprotkb:A1L4B8|uniprotkb:Q4PJH5|ensembl:ENSP00000225275	intact:EBI-6677628|ensembl:ENSP00000263408	psi-mi:perm_human(display_long)|uniprotkb:MPO(gene name)|psi-mi:MPO(display_short)	psi-mi:co9_human(display_long)|uniprotkb:C9(gene name)|psi-mi:C9(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	O'Flynn et al. (2013)	pubmed:24355864|imex:IM-27336	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22014316|imex:IM-27336-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000241.1|ensembl:ENSG00000005381(gene)|go:"GO:0002149"(hypochlorous acid biosynthetic process)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003682"(chromatin binding)|ensembl:ENST00000225275(transcript)|go:"GO:0001878"(response to yeast)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006952"(defense response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0032094"(response to food)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042582"(azurophil granule)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1990268"(response to gold nanoparticle)|interpro:IPR010255(Haem peroxidase)|interpro:IPR019791|interpro:IPR029609|interpro:IPR037120|mint:P05164|rcsb pdb:1CXP|rcsb pdb:1D2V|rcsb pdb:1D5L|rcsb pdb:1D7W|rcsb pdb:1DNU|rcsb pdb:1DNW|rcsb pdb:1MHL|rcsb pdb:1MYP|rcsb pdb:3F9P|rcsb pdb:3ZS0|rcsb pdb:3ZS1|rcsb pdb:4C1M|rcsb pdb:4DL1|rcsb pdb:4EJX|rcsb pdb:5FIW|rcsb pdb:5MFA|rcsb pdb:5UZU|rcsb pdb:6AZP|rcsb pdb:6BMT|reactome:R-HSA-6798695|reactome:R-HSA-8941413	refseq:NP_001728.1|dip:DIP-1124N|ensembl:ENSG00000113600(gene)|ensembl:ENST00000263408(transcript)|go:"GO:0001906"(cell killing)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0019835"(cytolysis)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001862(Membrane attack complex component/perforin/complement C9)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR020863|interpro:IPR020864|interpro:IPR023415|interpro:IPR036055|interpro:IPR036383|interpro:IPR037567|rcsb pdb:5FMW|rcsb pdb:6DLW|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606	-	-	-	figure legend:7|agonist:Buffer containing magnesium salt of EGTA.|comment:Buffer containing EDTA.|comment:"The monoclonal antibody (clone AE-11) used to detect binding of C5b-9,  is directed against a neoepitope exposed on C9 when incorporated into the membrane attack complex (MAC) or terminal complement complex (TCC)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/04	rogid:SNoAXb3csr/iOyGWeyWcUyJTZLY9606	rogid:XzPZJ9OUi00H+87so48Q/n+GXds9606	rigid:C6xAodfIr6QAoqiC1qVa0sAVnrc	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P05164	uniprotkb:P27918	intact:EBI-2556173|uniprotkb:Q14862|uniprotkb:Q9UCL7|uniprotkb:A1L4B8|uniprotkb:Q4PJH5|ensembl:ENSP00000225275	intact:EBI-9038570|uniprotkb:O15134|uniprotkb:O15135|uniprotkb:O15136|uniprotkb:O75826|ensembl:ENSP00000247153|ensembl:ENSP00000380189	psi-mi:perm_human(display_long)|uniprotkb:MPO(gene name)|psi-mi:MPO(display_short)	psi-mi:prop_human(display_long)|uniprotkb:CFP(gene name)|psi-mi:CFP(display_short)|uniprotkb:PFC(gene name synonym)|uniprotkb:Complement factor P(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	O'Flynn et al. (2013)	pubmed:24355864|imex:IM-27336	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22014325|imex:IM-27336-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000241.1|ensembl:ENSG00000005381(gene)|go:"GO:0002149"(hypochlorous acid biosynthetic process)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003682"(chromatin binding)|ensembl:ENST00000225275(transcript)|go:"GO:0001878"(response to yeast)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006952"(defense response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0032094"(response to food)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042582"(azurophil granule)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1990268"(response to gold nanoparticle)|interpro:IPR010255(Haem peroxidase)|interpro:IPR019791|interpro:IPR029609|interpro:IPR037120|mint:P05164|rcsb pdb:1CXP|rcsb pdb:1D2V|rcsb pdb:1D5L|rcsb pdb:1D7W|rcsb pdb:1DNU|rcsb pdb:1DNW|rcsb pdb:1MHL|rcsb pdb:1MYP|rcsb pdb:3F9P|rcsb pdb:3ZS0|rcsb pdb:3ZS1|rcsb pdb:4C1M|rcsb pdb:4DL1|rcsb pdb:4EJX|rcsb pdb:5FIW|rcsb pdb:5MFA|rcsb pdb:5UZU|rcsb pdb:6AZP|rcsb pdb:6BMT|reactome:R-HSA-6798695|reactome:R-HSA-8941413	refseq:NP_001138724.1|refseq:NP_002612.1|ensembl:ENSG00000126759(gene)|ensembl:ENST00000247153(transcript)|ensembl:ENST00000396992(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006955"(immune response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR036383|rcsb pdb:1W0R|rcsb pdb:1W0S|rcsb pdb:6RUR|rcsb pdb:6RUS|rcsb pdb:6RUV|rcsb pdb:6RV6|rcsb pdb:6S08|rcsb pdb:6S0A|rcsb pdb:6S0B|rcsb pdb:6SEJ|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-5083635|reactome:R-HSA-5173214|reactome:R-HSA-6798695|reactome:R-HSA-977606	-	-	-	figure legend:8|comment:All components were purified.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/04	rogid:SNoAXb3csr/iOyGWeyWcUyJTZLY9606	rogid:XBExMxbnkfjvnV9zHMRZgxZWKaw9606	rigid:c3XcEXqKPTnO5bKqMlXVAqaXgLk	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P05164	uniprotkb:P01024	intact:EBI-2556173|uniprotkb:Q14862|uniprotkb:Q9UCL7|uniprotkb:A1L4B8|uniprotkb:Q4PJH5|ensembl:ENSP00000225275	intact:EBI-905851|uniprotkb:A7E236|ensembl:ENSP00000245907	psi-mi:perm_human(display_long)|uniprotkb:MPO(gene name)|psi-mi:MPO(display_short)	psi-mi:co3_human(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:CPAMD1(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	O'Flynn et al. (2013)	pubmed:24355864|imex:IM-27336	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22014325|imex:IM-27336-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000241.1|ensembl:ENSG00000005381(gene)|go:"GO:0002149"(hypochlorous acid biosynthetic process)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003682"(chromatin binding)|ensembl:ENST00000225275(transcript)|go:"GO:0001878"(response to yeast)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006952"(defense response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0032094"(response to food)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042582"(azurophil granule)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1990268"(response to gold nanoparticle)|interpro:IPR010255(Haem peroxidase)|interpro:IPR019791|interpro:IPR029609|interpro:IPR037120|mint:P05164|rcsb pdb:1CXP|rcsb pdb:1D2V|rcsb pdb:1D5L|rcsb pdb:1D7W|rcsb pdb:1DNU|rcsb pdb:1DNW|rcsb pdb:1MHL|rcsb pdb:1MYP|rcsb pdb:3F9P|rcsb pdb:3ZS0|rcsb pdb:3ZS1|rcsb pdb:4C1M|rcsb pdb:4DL1|rcsb pdb:4EJX|rcsb pdb:5FIW|rcsb pdb:5MFA|rcsb pdb:5UZU|rcsb pdb:6AZP|rcsb pdb:6BMT|reactome:R-HSA-6798695|reactome:R-HSA-8941413	refseq:NP_000055.2|dip:DIP-35180N|ensembl:ENSG00000125730(gene)|ensembl:ENST00000245907(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01024|rcsb pdb:1C3D|rcsb pdb:1GHQ|rcsb pdb:1W2S|rcsb pdb:2A73|rcsb pdb:2A74|rcsb pdb:2GOX|rcsb pdb:2I07|rcsb pdb:2ICE|rcsb pdb:2ICF|rcsb pdb:2NOJ|rcsb pdb:2QKI|rcsb pdb:2WII|rcsb pdb:2WIN|rcsb pdb:2WY7|rcsb pdb:2WY8|rcsb pdb:2XQW|rcsb pdb:2XWB|rcsb pdb:2XWJ|rcsb pdb:3D5R|rcsb pdb:3D5S|rcsb pdb:3G6J|rcsb pdb:3L3O|rcsb pdb:3L5N|rcsb pdb:3NMS|rcsb pdb:3OED|rcsb pdb:3OHX|rcsb pdb:3OXU|rcsb pdb:3RJ3|rcsb pdb:3T4A|rcsb pdb:4HW5|rcsb pdb:4HWJ|rcsb pdb:4I6O|rcsb pdb:4M76|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5FO7|rcsb pdb:5FO8|rcsb pdb:5FO9|rcsb pdb:5FOA|rcsb pdb:5FOB|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:6EHG|rcsb pdb:6RMT|rcsb pdb:6RMU|rcsb pdb:6RUR|rcsb pdb:6RUV|rcsb pdb:6S0B|rcsb pdb:6YO6|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-198933|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9660826|reactome:R-HSA-977606	-	-	-	figure legend:8|comment:All components were purified.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/04	rogid:SNoAXb3csr/iOyGWeyWcUyJTZLY9606	rogid:6Axa89cCPpUXFsLnd7sCurZzLYI9606	rigid:c3XcEXqKPTnO5bKqMlXVAqaXgLk	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)