#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8IXL6	uniprotkb:P10451	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-723648|ensembl:ENSP00000378517|ensembl:ENSP00000477824|uniprotkb:Q15681|uniprotkb:Q15682|uniprotkb:Q15683|uniprotkb:Q8NBK2|uniprotkb:Q96IZ1|uniprotkb:B2RDA1|uniprotkb:Q4W597|uniprotkb:Q567T5	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:ostp_human(display_long)|uniprotkb:Bone sialoprotein 1(gene name synonym)|uniprotkb:Secreted phosphoprotein 1(gene name synonym)|uniprotkb:Urinary stone protein(gene name synonym)|uniprotkb:Nephropontin(gene name synonym)|uniprotkb:Uropontin(gene name synonym)|uniprotkb:SPP1(gene name)|psi-mi:SPP1(display_short)|uniprotkb:OPN(gene name synonym)|uniprotkb:PSEC0156(orf name)|uniprotkb:BNSP(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2015)	pubmed:26091039|imex:IM-25714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13645769|imex:IM-25714-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_000573.1|refseq:NP_001035147.1|ensembl:ENSG00000118785(gene)|ensembl:ENST00000395080(transcript)|ensembl:ENST00000614857(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006710"(androgen catabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007566"(embryo implantation)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033280"(response to vitamin D)|go:"GO:0042995"(cell projection)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048685"(negative regulation of collateral sprouting of intact axon in response to injury)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:2000866"(positive regulation of estradiol secretion)|interpro:IPR002038(Osteopontin)|interpro:IPR019841|mint:P10451|rcsb pdb:3CXD|rcsb pdb:3DSF|reactome:R-HSA-1474228|reactome:R-HSA-186797|reactome:R-HSA-216083|reactome:R-HSA-381426|reactome:R-HSA-8949275|reactome:R-HSA-8957275|go:"GO:0046697"(decidualization)|refseq:NP_001035149.1|refseq:NP_001238758.1|refseq:NP_001238759.1|dip:DIP-49933N|go:"GO:0006468"(protein phosphorylation)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:2I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/14	2017/02/15	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:a1xqyCMAIQpBwLFBbfKN7R+7K3M9606	rigid:0DEdYpFX2bSTlLAUFB+p/EHWYt4	false	flag tag:c-c	his tag:c-c|v5 tag:c-c	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P08833	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-13646303|ensembl:ENSP00000275525|uniprotkb:A4D2F4|uniprotkb:D3DVL9|uniprotkb:Q8IYP5	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:ibp1_human(display_long)|uniprotkb:IGFBP1(gene name)|psi-mi:IGFBP1(display_short)|uniprotkb:IBP1(gene name synonym)|uniprotkb:Placental protein 12(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2015)	pubmed:26091039|imex:IM-25714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13646370|imex:IM-25714-4	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	ensembl:ENSG00000146678(gene)|ensembl:ENST00000275525(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007165"(signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0042246"(tissue regeneration)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017891|interpro:IPR022321|interpro:IPR022322|reactome:R-HSA-8957275|reactome:R-HSA-9615017|interpro:IPR036857|rcsb pdb:1ZT3|rcsb pdb:1ZT5|rcsb pdb:2DSQ|reactome:R-HSA-380994|reactome:R-HSA-381426|refseq:NP_000587.1|dip:DIP-59846N|go:"GO:0006468"(protein phosphorylation)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:5E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/14	2017/02/15	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:508HADo+AQGlRdHL3Yqk7Hyhjv09606	rigid:hdKQBZ2iOmdBZYDPSB6/6o+Fjbs	false	flag tag:c-c|mutation disrupting interaction rate:478-478	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8NBP7	uniprotkb:Q8IXL6	intact:EBI-7539251|intact:MINT-3041747|uniprotkb:C0JYY9|uniprotkb:Q5SZQ2|uniprotkb:Q5PSM5|intact:MINT-4888810|uniprotkb:A8T640|ensembl:ENSP00000303208	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	psi-mi:pcsk9_human(display_long)|uniprotkb:Subtilisin/kexin-like protease PC9(gene name synonym)|uniprotkb:Neural apoptosis-regulated convertase 1(gene name synonym)|uniprotkb:Proprotein convertase 9(gene name synonym)|uniprotkb:PCSK9(gene name)|psi-mi:PCSK9(display_short)|uniprotkb:NARC1(gene name synonym)|uniprotkb:PSEC0052(orf name)	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2015)	pubmed:26091039|imex:IM-25714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13915342|imex:IM-25714-7	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777596.2|ensembl:ENSG00000169174(gene)|ensembl:ENST00000302118(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009986"(cell surface)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032802"(low-density lipoprotein particle receptor catabolic process)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:1905596"(negative regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:1905601"(negative regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990666"(PCSK9-LDLR complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|interpro:IPR041051|interpro:IPR041052|interpro:IPR041254|rcsb pdb:2P4E|rcsb pdb:2PMW|rcsb pdb:2QTW|rcsb pdb:2W2M|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:2XTJ|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3H42|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SQO|rcsb pdb:4K8R|rcsb pdb:4NE9|rcsb pdb:4NMX|rcsb pdb:4OV6|rcsb pdb:5OCA|rcsb pdb:5VL7|rcsb pdb:5VLA|rcsb pdb:5VLH|rcsb pdb:5VLK|rcsb pdb:5VLL|rcsb pdb:5VLP|rcsb pdb:6E4Y|rcsb pdb:6E4Z|rcsb pdb:6F5G|rcsb pdb:6MV5|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6U26|rcsb pdb:6U2F|rcsb pdb:6U2N|rcsb pdb:6U2P|rcsb pdb:6U36|rcsb pdb:6U38|rcsb pdb:6U3I|rcsb pdb:6U3X|reactome:R-HSA-381426|reactome:R-HSA-8866427|reactome:R-HSA-8957275|reactome:R-HSA-8964038|dip:DIP-29694N	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	comment:mint|comment:homomint|function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis|function:"Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant"	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/14	2017/02/16	rogid:QWrUgh1cMkAa3Sj99SPlVcePIQs9606	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rigid:ycq93Oc9BDxiLwbHrHaVmg7iWrg	false	flag tag:c-c	mutation disrupting interaction rate:478-478|flag tag:c-c	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P17936	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-715709|uniprotkb:Q2V509|uniprotkb:Q6P1M6|uniprotkb:A4D2F5|uniprotkb:Q9UCL4|uniprotkb:D3DVM0|ensembl:ENSP00000477772	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:ibp3_human(display_long)|uniprotkb:IGFBP3(gene name)|psi-mi:IGFBP3(display_short)|uniprotkb:IBP3(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2015)	pubmed:26091039|imex:IM-25714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13915355|imex:IM-25714-8	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_000589.2|refseq:NP_001013416.1|ensembl:ENSG00000146674(gene)|ensembl:ENST00000613132(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008160"(protein tyrosine phosphatase activator activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016942"(insulin-like growth factor binding protein complex)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR012211(Insulin-like growth factor binding protein 3)|interpro:IPR017891|interpro:IPR022321|interpro:IPR036857|mint:P17936|reactome:R-HSA-381426|reactome:R-HSA-6803211|reactome:R-HSA-8957275|refseq:XP_016867641.1|dip:DIP-40786N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:4A-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/14	2017/02/16	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:zb2NzKqdY6oCXbF/DrT5etyMeEU9606	rigid:tYGweBaNare9IU+R5NjxPJQauoM	false	mutation disrupting interaction rate:478-478|flag tag:c-c	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P02765	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-1223374|uniprotkb:O14961|uniprotkb:O14962|uniprotkb:Q9P152|uniprotkb:A8K9N6|uniprotkb:B2R7G1|ensembl:ENSP00000393887	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:fetua_human(display_long)|uniprotkb:AHSG(gene name)|psi-mi:AHSG(display_short)|uniprotkb:FETUA(gene name synonym)|uniprotkb:PRO2743(orf name)|uniprotkb:Ba-alpha-2-glycoprotein(gene name synonym)|uniprotkb:Alpha-2-Z-globulin(gene name synonym)|uniprotkb:Fetuin-A(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2015)	pubmed:26091039|imex:IM-25714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13915367|imex:IM-25714-9	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_001613.2|ensembl:ENSG00000145192(gene)|ensembl:ENST00000411641(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006907"(pinocytosis)|go:"GO:0006953"(acute-phase response)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR001363(Proteinase inhibitor I25C, fetuin, conserved site)|interpro:IPR025760|mint:P02765|reactome:R-HSA-114608|reactome:R-HSA-381426|reactome:R-HSA-6798695|reactome:R-HSA-8957275	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:4A-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/14	2018/09/18	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:2SoUaMokkmtdRNazI9k95s9E9H49606	rigid:bYlDYNdlghdt+aTLYZ9z7tq+pD8	false	mutation disrupting interaction rate:478-478|flag tag:c-c	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P24593	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-720480|uniprotkb:Q5U0A3|ensembl:ENSP00000233813	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:ibp5_human(display_long)|uniprotkb:IGFBP5(gene name)|psi-mi:IGFBP5(display_short)|uniprotkb:IBP5(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2015)	pubmed:26091039|imex:IM-25714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13915377|imex:IM-25714-10	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	go:"GO:0071407"(cellular response to organic cyclic compound)|refseq:NP_000590.1|dip:DIP-48433N|ensembl:ENSG00000115461(gene)|ensembl:ENST00000233813(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007165"(signal transduction)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016942"(insulin-like growth factor binding protein complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:1904205"(negative regulation of skeletal muscle hypertrophy)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR012213(Insulin-like growth factor binding protein 5)|interpro:IPR017891|interpro:IPR022321|interpro:IPR036857|rcsb pdb:1BOE|rcsb pdb:1H59|reactome:R-HSA-381426|reactome:R-HSA-8957275|go:"GO:1901862"(negative regulation of muscle tissue development)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:4A-4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/14	2017/02/16	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:NeQ0QcVrpNzyqWlmp/HvG5FIRHA9606	rigid:Jv8SU/Ysk1dMlwfJ+D3T4dgWiZY	false	flag tag:c-c|mutation disrupting interaction rate:478-478	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P02751	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2015)	pubmed:26091039|imex:IM-25714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13915387|imex:IM-25714-11	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:4A-5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/14	2019/10/18	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:4arZu49X8b+dthqaX4DIh59V8h09606	rigid:yiG1Q0e8BVl0LVerUuc2ixeqWww	false	flag tag:c-c|mutation disrupting interaction rate:478-478	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P02671	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-348571|ensembl:ENSP00000498441|uniprotkb:Q9BX62|uniprotkb:Q9UCH2|uniprotkb:A8K3E4|uniprotkb:Q4QQH7|uniprotkb:D3DP14|uniprotkb:D3DP15	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:fiba_human(display_long)|uniprotkb:FGA(gene name)|psi-mi:FGA(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2015)	pubmed:26091039|imex:IM-25714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13915397|imex:IM-25714-12	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_000499.1|refseq:NP_068657.1|ensembl:ENSG00000171560(gene)|ensembl:ENST00000651975(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000261"(negative regulation of blood coagulation, common pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072377"(blood coagulation, common pathway)|interpro:IPR021996|interpro:IPR036056|interpro:IPR037579|mint:P02671|rcsb pdb:1BBR|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1DM4|rcsb pdb:1FPH|rcsb pdb:1FZA|rcsb pdb:1FZB|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|rcsb pdb:1FZC|rcsb pdb:1FZD|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0042730"(fibrinolysis)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0045087"(innate immune response)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1FZF|rcsb pdb:1FZG|rcsb pdb:1LT9|rcsb pdb:1LTJ|rcsb pdb:1N86|rcsb pdb:1N8E|rcsb pdb:1RE3|rcsb pdb:1RE4|rcsb pdb:1RF0|rcsb pdb:1RF1|rcsb pdb:1YCP|rcsb pdb:2A45|rcsb pdb:2FFD|rcsb pdb:2H43|rcsb pdb:2HLO|rcsb pdb:2HOD|rcsb pdb:2HPC|rcsb pdb:2OYH|rcsb pdb:2OYI|rcsb pdb:2Q9I|rcsb pdb:2XNX|rcsb pdb:2XNY|rcsb pdb:2Z4E|rcsb pdb:3AT0|rcsb pdb:1FZE|rcsb pdb:3BVH|rcsb pdb:3E1I|rcsb pdb:3GHG|rcsb pdb:3H32|rcsb pdb:3HUS|rcsb pdb:4F27|rcsb pdb:5CFA|reactome:R-HSA-114608|reactome:R-HSA-1236974|reactome:R-HSA-5674135|reactome:R-HSA-140875|reactome:R-HSA-166058|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-5686938|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-977225|dip:DIP-29643N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:4A-6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/14	2017/02/16	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:khlQGVpd+6qZLTrsT9KxlxgjMR09606	rigid:XzHzj17nivEFlisiMbhw2+66Pbc	false	flag tag:c-c|mutation disrupting interaction rate:478-478	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8IXL6	uniprotkb:O43852	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-1171069|uniprotkb:O60456|uniprotkb:Q6FHB9|uniprotkb:Q96RL3|uniprotkb:Q9NR43|intact:EBI-2554631|uniprotkb:B3KPG9|uniprotkb:D6QS48|uniprotkb:D6QS49|uniprotkb:D6QS50|uniprotkb:D6QS51|uniprotkb:D6QS52|uniprotkb:D6QS53|uniprotkb:D6QS54|uniprotkb:D6QS55|uniprotkb:D6QS56|uniprotkb:D6QS57|uniprotkb:D6QS58|uniprotkb:D6QS59|uniprotkb:F5H1Q9|uniprotkb:F5H879|ensembl:ENSP00000249364	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:calu_human(display_long)|uniprotkb:CALU(gene name)|psi-mi:CALU(display_short)|uniprotkb:Crocalbin(gene name synonym)|uniprotkb:IEF SSP 9302(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2015)	pubmed:26091039|imex:IM-25714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13915407|imex:IM-25714-13	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_001124146.1|refseq:NP_001186602.1|refseq:NP_001210.1|refseq:NP_001186600.1|refseq:NP_001186601.1|ensembl:ENSG00000128595(gene)|ensembl:ENST00000249364(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016020"(membrane)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0042470"(melanosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR027239|mint:O43852|reactome:R-HSA-114608|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:XP_016868148.1	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:4B-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/14	2017/02/16	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:lgl1dEYzu+XFHq3QJ/w69xg51Ts9606	rigid:p1FxBFQTi1uvZ8C8RjmQw/Mdt+0	false	flag tag:c-c|mutation disrupting interaction rate:478-478	his tag:n-n|maltose binding protein tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P05231	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-720533|uniprotkb:Q9UCU4|uniprotkb:Q9UCU2|uniprotkb:Q9UCU3|ensembl:ENSP00000258743|ensembl:ENSP00000385675	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:il6_human(display_long)|uniprotkb:B-cell stimulatory factor 2(gene name synonym)|uniprotkb:Interferon beta-2(gene name synonym)|uniprotkb:Hybridoma growth factor(gene name synonym)|uniprotkb:CTL differentiation factor(gene name synonym)|uniprotkb:IL6(gene name)|psi-mi:IL6(display_short)|uniprotkb:IFNB2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2015)	pubmed:26091039|imex:IM-25714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13915421|imex:IM-25714-14	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	go:"GO:0001781"(neutrophil apoptotic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0050871"(positive regulation of B cell activation)|refseq:NP_000591.1|refseq:XP_011513692.1|dip:DIP-482N|ensembl:ENSG00000136244(gene)|ensembl:ENST00000258743(transcript)|ensembl:ENST00000404625(transcript)|go:"GO:0002384"(hepatic immune response)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010574"(regulation of vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014823"(response to activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030168"(platelet activation)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031175"(neuron projection development)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032745"(positive regulation of interleukin-21 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051607"(defense response to virus)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:0061888"(regulation of astrocyte activation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070091"(glucagon secretion)|go:"GO:0070092"(regulation of glucagon secretion)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:0097421"(liver regeneration)|go:"GO:0098586"(cellular response to virus)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901731"(positive regulation of platelet aggregation)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903978"(regulation of microglial cell activation)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003574(Interleukin-6)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR030473|interpro:IPR030474|rcsb pdb:1ALU|rcsb pdb:1IL6|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:2IL6|rcsb pdb:4CNI|rcsb pdb:4J4L|rcsb pdb:4NI7|rcsb pdb:4NI9|rcsb pdb:4O9H|rcsb pdb:4ZS7|rcsb pdb:5FUC|rcsb pdb:7NXZ|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-2559582|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8853884|reactome:R-HSA-8957275|reactome:R-HSA-9660821|reactome:R-HSA-9662834	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:4B-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/14	2017/02/16	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:6vjM8nCX9dFO2PtS54SfLqw0K0w9606	rigid:7OL+USKe6zk3GgDuBiuz1H8Q/Ic	false	flag tag:c-c|mutation disrupting interaction rate:478-478	his tag:n-n|maltose binding protein tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8IXL6	uniprotkb:O76061	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-713858|ensembl:ENSP00000265087	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:stc2_human(display_long)|uniprotkb:Stanniocalcin-related protein(gene name synonym)|uniprotkb:STC2(gene name)|psi-mi:STC2(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2015)	pubmed:26091039|imex:IM-25714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13915435|imex:IM-25714-15	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	ensembl:ENSG00000113739(gene)|ensembl:ENST00000265087(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007566"(embryo implantation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0033280"(response to vitamin D)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0046697"(decidualization)|go:"GO:0046885"(regulation of hormone biosynthetic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR004978(Stanniocalcin)|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_003705.1	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:4B-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/14	2017/02/16	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:qeBQhJwK594qy2xTfnfEwbeguuw9606	rigid:avaX9386ZHiNOmXwtRJn7QNZCSo	false	flag tag:c-c|mutation disrupting interaction rate:478-478	his tag:n-n|maltose binding protein tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8IXL6	uniprotkb:Q02818	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-2622179|uniprotkb:Q7Z4J7|uniprotkb:B2RD64|uniprotkb:Q9BUR1|uniprotkb:Q15838|intact:EBI-28978015|ensembl:ENSP00000385211|ensembl:ENSP00000385923	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:nucb1_human(display_long)|uniprotkb:NUC(gene name synonym)|uniprotkb:CALNUC(gene name synonym)|uniprotkb:NUCB1(gene name)|psi-mi:NUCB1(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2015)	pubmed:26091039|imex:IM-25714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13915449|imex:IM-25714-16	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	ensembl:ENSP00000385923|ensembl:ENSP00000385211|refseq:NP_006175.2|refseq:XP_016882334.1|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072718"(response to cisplatin)|go:"GO:0090498"(extrinsic component of Golgi membrane)|go:"GO:0098547"(lumenal side of Golgi membrane)|go:"GO:1903533"(regulation of protein targeting)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR040250|interpro:IPR040253|mint:Q02818|rcsb pdb:1SNL|reactome:R-HSA-381426|reactome:R-HSA-8957275|ensembl:ENSG00000104805(gene)|ensembl:ENST00000405315(transcript)|ensembl:ENST00000407032(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:4B-4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/14	2017/02/16	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:exoVYPq5+NxEpgkm/gAQay/Uwuk9606	rigid:tbMZuAaawugjm7nlDHI1PzmeNPI	false	flag tag:c-c|mutation disrupting interaction rate:478-478	his tag:n-n|maltose binding protein tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8IXL6	uniprotkb:P02666	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-5260183|uniprotkb:A1YQZ8|uniprotkb:A6N8V0|uniprotkb:Q2TA13|uniprotkb:Q5EEQ6|uniprotkb:Q5EEQ7|uniprotkb:Q6UN63|uniprotkb:Q9BDG5|uniprotkb:Q9TSD5	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:casb_bovin(display_long)|uniprotkb:CSN2(gene name)|psi-mi:CSN2(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2015)	pubmed:26091039|imex:IM-25714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13645805|imex:IM-25714-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	dip:DIP-46257N|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009408"(response to heat)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1903488"(negative regulation of lactation)|go:"GO:1903494"(response to dehydroepiandrosterone)|go:"GO:1903496"(response to 11-deoxycorticosterone)|go:"GO:1903720"(negative regulation of I-kappaB phosphorylation)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|interpro:IPR001588(Casein, alpha/beta)|interpro:IPR016345(Casein, beta)|interpro:IPR031305	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:2J, 5H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/14	2017/02/15	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:wtuOGN4l9NtBjB0YyHhilo7usl49913	rigid:hEAEa5IfA6MG8UIHsTgGT8ctSTY	false	flag tag:c-c	sufficient binding region:43-55	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q8IXL6	uniprotkb:P02810	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-738601|uniprotkb:Q4VBP2|uniprotkb:Q53XA2|uniprotkb:Q6P2F6|uniprotkb:A2VCM0|uniprotkb:A3KN66|uniprotkb:A5D902|uniprotkb:B2RMW2|ensembl:ENSP00000371271|ensembl:ENSP00000379682|ensembl:ENSP00000458690|ensembl:ENSP00000461041|ensembl:ENSP00000481810|ensembl:ENSP00000483458	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:prpc_human(display_long)|uniprotkb:PRH1(gene name)|psi-mi:PRH1(display_short)|uniprotkb:PRH2(gene name)|psi-mi:PRH2(display_short)|uniprotkb:PRP-1/PRP-2(gene name synonym)|uniprotkb:Parotid proline-rich protein 1/2(gene name synonym)|uniprotkb:Pr1/Pr2(gene name synonym)|uniprotkb:Protein C(gene name synonym)|uniprotkb:Parotid acidic protein(gene name synonym)|uniprotkb:Parotid isoelectric focusing variant protein(gene name synonym)|uniprotkb:Parotid double-band protein(gene name synonym)|uniprotkb:Db-s(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2015)	pubmed:26091039|imex:IM-25714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13646391|imex:IM-25714-5	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_001278243.1|refseq:NP_001278244.1|refseq:NP_001103683.1|ensembl:ENSG00000134551(gene)|ensembl:ENSG00000272803(gene)|ensembl:ENSG00000275679(gene)|ensembl:ENST00000381847(transcript)|ensembl:ENST00000396400(transcript)|ensembl:ENST00000572141(transcript)|ensembl:ENST00000575657(transcript)|ensembl:ENST00000622570(transcript)|ensembl:ENST00000622848(transcript)|go:"GO:0005615"(extracellular space)|interpro:IPR026086|mint:P02810	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:5H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/14	2017/02/15	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:u2v00Il3agr2ZJIHSmrqcRa31DI9606	rigid:WS67GzEDcqPhqsx7kzMlEl53rQI	false	flag tag:c-c	sufficient binding region:35-45|mutation:34-35|O-phospho-L-serine:38-38	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q8IXL6	uniprotkb:P08833	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-13646303|ensembl:ENSP00000275525|uniprotkb:A4D2F4|uniprotkb:D3DVL9|uniprotkb:Q8IYP5	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:ibp1_human(display_long)|uniprotkb:IGFBP1(gene name)|psi-mi:IGFBP1(display_short)|uniprotkb:IBP1(gene name synonym)|uniprotkb:Placental protein 12(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2015)	pubmed:26091039|imex:IM-25714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13646290|imex:IM-25714-3	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	ensembl:ENSG00000146678(gene)|ensembl:ENST00000275525(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007165"(signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0042246"(tissue regeneration)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017891|interpro:IPR022321|interpro:IPR022322|reactome:R-HSA-8957275|reactome:R-HSA-9615017|interpro:IPR036857|rcsb pdb:1ZT3|rcsb pdb:1ZT5|rcsb pdb:2DSQ|reactome:R-HSA-380994|reactome:R-HSA-381426|refseq:NP_000587.1|dip:DIP-59846N|go:"GO:0006468"(protein phosphorylation)	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:Fig 5F, Supp 6 E/F|comment:Fam20C was unable to phosphorylate these residues when synthetic peptides were used as  substrates.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/14	2017/02/28	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:508HADo+AQGlRdHL3Yqk7Hyhjv09606	rigid:hdKQBZ2iOmdBZYDPSB6/6o+Fjbs	false	flag tag:c-c|mutation disrupting interaction rate:478-478	O-phospho-L-serine:194-194|O-phospho-L-serine:45-45|O-phospho-L-threonine:193-193|O-phospho-L-serine:199-199	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IXL6	uniprotkb:P02810	intact:EBI-7147442|uniprotkb:L8B5W8|ensembl:ENSP00000322323|ensembl:ENSP00000499851|uniprotkb:Q7Z4I0|uniprotkb:Q5I0W9|intact:MINT-6940404|uniprotkb:A4D2Q5|uniprotkb:Q9NPT2	intact:EBI-738601|uniprotkb:Q4VBP2|uniprotkb:Q53XA2|uniprotkb:Q6P2F6|uniprotkb:A2VCM0|uniprotkb:A3KN66|uniprotkb:A5D902|uniprotkb:B2RMW2|ensembl:ENSP00000371271|ensembl:ENSP00000379682|ensembl:ENSP00000458690|ensembl:ENSP00000461041|ensembl:ENSP00000481810|ensembl:ENSP00000483458	psi-mi:fa20c_human(display_long)|uniprotkb:Dentin matrix protein 4(gene name synonym)|uniprotkb:Golgi-enriched fraction casein kinase(gene name synonym)|uniprotkb:FAM20C(gene name)|psi-mi:FAM20C(display_short)|uniprotkb:DMP4(gene name synonym)|uniprotkb:Golgi casein kinase(gene name synonym)	psi-mi:prpc_human(display_long)|uniprotkb:PRH1(gene name)|psi-mi:PRH1(display_short)|uniprotkb:PRH2(gene name)|psi-mi:PRH2(display_short)|uniprotkb:PRP-1/PRP-2(gene name synonym)|uniprotkb:Parotid proline-rich protein 1/2(gene name synonym)|uniprotkb:Pr1/Pr2(gene name synonym)|uniprotkb:Protein C(gene name synonym)|uniprotkb:Parotid acidic protein(gene name synonym)|uniprotkb:Parotid isoelectric focusing variant protein(gene name synonym)|uniprotkb:Parotid double-band protein(gene name synonym)|uniprotkb:Db-s(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tagliabracci et al. (2015)	pubmed:26091039|imex:IM-25714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13646416|imex:IM-25714-6	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177706(gene)|ensembl:ENSG00000288499(gene)|ensembl:ENST00000313766(transcript)|ensembl:ENST00000672066(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071895"(odontoblast differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR009581(Protein of unknown function DUF1193)|interpro:IPR024869|rcsb pdb:5YH3|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_064608.2	refseq:NP_001278243.1|refseq:NP_001278244.1|refseq:NP_001103683.1|ensembl:ENSG00000134551(gene)|ensembl:ENSG00000272803(gene)|ensembl:ENSG00000275679(gene)|ensembl:ENST00000381847(transcript)|ensembl:ENST00000396400(transcript)|ensembl:ENST00000572141(transcript)|ensembl:ENST00000575657(transcript)|ensembl:ENST00000622570(transcript)|ensembl:ENST00000622848(transcript)|go:"GO:0005615"(extracellular space)|interpro:IPR026086|mint:P02810	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	function:Calcium-binding protein which may play a role in dentin mineralization|function:"Defects in FAM20C are the cause of Raine syndrome (RNS) [MIM:259775]. RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly"|comment:mint|comment:homomint	-	figure legend:5I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/14	2017/02/15	rogid:hro7o7c0vsYAzpP2iQblks6dvfs9606	rogid:u2v00Il3agr2ZJIHSmrqcRa31DI9606	rigid:WS67GzEDcqPhqsx7kzMlEl53rQI	false	flag tag:c-c	mutation disrupting interaction rate:38-38|mutation decreasing interaction rate:43-43|mutation disrupting interaction rate:38-38|mutation decreasing interaction rate:43-43|mutation decreasing interaction rate:44-44|mutation decreasing interaction rate:44-44|mutation decreasing interaction rate:45-45|mutation decreasing interaction rate:45-45|mutation decreasing interaction rate:44-45|mutation disrupting interaction rate:43-45|sufficient binding region:34-45|O-phospho-L-serine:38-38	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)