#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13873	uniprotkb:Q62356	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	intact:EBI-2564326|uniprotkb:Q6GTX2|uniprotkb:Q99JI9|ensembl:ENSMUSP00000110411	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:fstl1_mouse(display_long)|uniprotkb:Fstl1(gene name)|psi-mi:Fstl1(display_short)|uniprotkb:Frp(gene name synonym)|uniprotkb:Fstl(gene name synonym)|uniprotkb:Tsc36(gene name synonym)|uniprotkb:Follistatin-like protein 1(gene name synonym)|uniprotkb:TGF-beta-inducible protein TSC-36(gene name synonym)	psi-mi:"MI:0096"(pull down)	Geng et al. (2011)	pubmed:21482757|doi:10.1073/pnas.1007293108|imex:IM-21236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15922102|imex:IM-21236-1|dip:DIP-191203E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)	refseq:NP_032073.2|ensembl:ENSMUSG00000022816(gene)|ensembl:ENSMUST00000114763(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0008201"(heparin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR036058|rcsb pdb:6JZA|dip:DIP-56414N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	rogid:G2DbY9TPo7LV+8gUIstCyykLszQ10090	rigid:JIH9oGXBMP3tG/MlllJACUzuF4o	false	sufficient binding region:27-1038|flag tag:c-c	sufficient binding region:19-306|his tag:n-n|myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P01137	uniprotkb:Q62356	intact:EBI-779636|uniprotkb:Q9UCG4|uniprotkb:A8K792	intact:EBI-2564326|uniprotkb:Q6GTX2|uniprotkb:Q99JI9|ensembl:ENSMUSP00000110411	psi-mi:tgfb1_human(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)|uniprotkb:TGFB(gene name synonym)	psi-mi:fstl1_mouse(display_long)|uniprotkb:Fstl1(gene name)|psi-mi:Fstl1(display_short)|uniprotkb:Frp(gene name synonym)|uniprotkb:Fstl(gene name synonym)|uniprotkb:Tsc36(gene name synonym)|uniprotkb:Follistatin-like protein 1(gene name synonym)|uniprotkb:TGF-beta-inducible protein TSC-36(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Geng et al. (2011)	pubmed:21482757|doi:10.1073/pnas.1007293108|imex:IM-21236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15922130|imex:IM-21236-2|dip:DIP-191205E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000651.3|mint:P01137|dip:DIP-5934N|go:"GO:0000165"(MAPK cascade)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KLA|rcsb pdb:1KLC|rcsb pdb:1KLD|rcsb pdb:3KFD|rcsb pdb:4KV5|rcsb pdb:5FFO|rcsb pdb:5VQP|rcsb pdb:6OM2|rcsb pdb:6P7J|reactome:R-HSA-114608|reactome:R-HSA-168277|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-381340|reactome:R-HSA-5689603|reactome:R-HSA-6785807|reactome:R-HSA-8941855|reactome:R-HSA-8941858|reactome:R-HSA-8951936	refseq:NP_032073.2|ensembl:ENSMUSG00000022816(gene)|ensembl:ENSMUST00000114763(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0008201"(heparin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR036058|rcsb pdb:6JZA|dip:DIP-56414N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:WjHm8ysG9Ab1pFfdtG9QbJeCdCw9606	rogid:G2DbY9TPo7LV+8gUIstCyykLszQ10090	rigid:ARRASRSt26WKSHY6/QKAz3pEkcQ	false	sufficient binding region:279-390	sufficient binding region:19-306	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12644	uniprotkb:Q62356	intact:EBI-1998134|uniprotkb:Q9UM80|ensembl:ENSP00000245451|ensembl:ENSP00000394165|ensembl:ENSP00000453485|ensembl:ENSP00000454134	intact:EBI-2564326|uniprotkb:Q6GTX2|uniprotkb:Q99JI9|ensembl:ENSMUSP00000110411	psi-mi:bmp4_human(display_long)|uniprotkb:BMP4(gene name)|psi-mi:BMP4(display_short)|uniprotkb:BMP2B(gene name synonym)|uniprotkb:DVR4(gene name synonym)|uniprotkb:Bone morphogenetic protein 2B(gene name synonym)	psi-mi:fstl1_mouse(display_long)|uniprotkb:Fstl1(gene name)|psi-mi:Fstl1(display_short)|uniprotkb:Frp(gene name synonym)|uniprotkb:Fstl(gene name synonym)|uniprotkb:Tsc36(gene name synonym)|uniprotkb:Follistatin-like protein 1(gene name synonym)|uniprotkb:TGF-beta-inducible protein TSC-36(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Geng et al. (2011)	pubmed:21482757|doi:10.1073/pnas.1007293108|imex:IM-21236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15922151|imex:IM-21236-3|dip:DIP-191204E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_570911.2|refseq:NP_001193.2|refseq:NP_001334843.1|refseq:NP_001334845.1|refseq:NP_570912.2|dip:DIP-5795N|go:"GO:0072200"(negative regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090184"(positive regulation of kidney development)|go:"GO:0090191"(negative regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090194"(negative regulation of glomerulus development)|go:"GO:1901964"(positive regulation of cell proliferation involved in outflow tract morphogenesis)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905312"(positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:2000005"(negative regulation of metanephric S-shaped body morphogenesis)|go:"GO:2000007"(negative regulation of metanephric comma-shaped body morphogenesis)|go:"GO:2000137"(negative regulation of cell proliferation involved in heart morphogenesis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|reactome:R-HSA-2129379|reactome:R-HSA-381426|reactome:R-HSA-8957275|ensembl:ENSG00000125378(gene)|ensembl:ENST00000245451(transcript)|ensembl:ENST00000417573(transcript)|ensembl:ENST00000558984(transcript)|ensembl:ENST00000559087(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0001823"(mesonephros development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003014"(renal system process)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007281"(germ cell development)|go:"GO:0007492"(endoderm development)|go:"GO:0007500"(mesodermal cell fate determination)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010159"(specification of animal organ position)|go:"GO:0010453"(regulation of cell fate commitment)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0021537"(telencephalon development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033085"(negative regulation of T cell differentiation in thymus)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035990"(tendon cell differentiation)|go:"GO:0035993"(deltoid tuberosity development)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043401"(steroid hormone mediated signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048392"(intermediate mesodermal cell differentiation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051150"(regulation of smooth muscle cell differentiation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055020"(positive regulation of cardiac muscle fiber development)|go:"GO:0060113"(inner ear receptor cell differentiation)|go:"GO:0060197"(cloacal septation)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060433"(bronchus development)|go:"GO:0060438"(trachea development)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060503"(bud dilation involved in lung branching)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060592"(mammary gland formation)|go:"GO:0060684"(epithelial-mesenchymal cell signaling)|go:"GO:0060686"(negative regulation of prostatic bud formation)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061149"(BMP signaling pathway involved in ureter morphogenesis)|go:"GO:0061151"(BMP signaling pathway involved in renal system segmentation)|go:"GO:0061155"(pulmonary artery endothelial tube morphogenesis)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0071893"(BMP signaling pathway involved in nephric duct formation)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072097"(negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway)|go:"GO:0072101"(specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway)|go:"GO:0072104"(glomerular capillary formation)|go:"GO:0072125"(negative regulation of glomerular mesangial cell proliferation)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0072161"(mesenchymal cell differentiation involved in kidney development)|go:"GO:0072192"(ureter epithelial cell differentiation)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072198"(mesenchymal cell proliferation involved in ureter development)	refseq:NP_032073.2|ensembl:ENSMUSG00000022816(gene)|ensembl:ENSMUST00000114763(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0008201"(heparin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR036058|rcsb pdb:6JZA|dip:DIP-56414N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:HQjZUJQMMkLov0JIQOQVh7NN7zM9606	rogid:G2DbY9TPo7LV+8gUIstCyykLszQ10090	rigid:dbfPjFieiNBzBI3ElYbPr+inNnY	false	sufficient binding region:293-408	sufficient binding region:19-306	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)