#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
refseq:XP_002718256	uniprotkb:P09616	intact:EBI-15865259|dip:DIP-59358N	intact:EBI-15848589	psi-mi:radam10(display_long)	psi-mi:hla_staau(display_long)|uniprotkb:hly(gene name)|psi-mi:hly(display_short)|uniprotkb:hla(gene name synonym)|uniprotkb:Alpha-toxin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wilke et al. (2010)	pubmed:20624979|doi:10.1073/pnas.1001815107|imex:IM-16450	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:1280(staau)|taxid:1280(Staphylococcus aureus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15865262|imex:IM-16450-1|dip:DIP-187684E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding)|go:"GO:0044179"(hemolysis in another organism)|go:"GO:0090729"(toxin activity)|interpro:IPR003963(Bi-component toxin, staphylococci)|interpro:IPR005831(Aerolysin/haemolysin toxin, conserved site)|interpro:IPR016183(Leukocidin/porin)|interpro:IPR036435|rcsb pdb:3M2L|rcsb pdb:3M3R|rcsb pdb:3M4D|rcsb pdb:3M4E|rcsb pdb:4IDJ|rcsb pdb:4YHD|rcsb pdb:6U3T|rcsb pdb:6U49|rcsb pdb:6U4P|rcsb pdb:7AHL|rcsb pdb:7O1Q|reactome:R-HSA-9660826|reactome:R-HSA-844456|dip:DIP-59322N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	-	rogid:0BR0y0GDnhSuti8YNFYvf2RGbqo1280	-	false	-	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
refseq:XP_002718256	uniprotkb:P09616	intact:EBI-15865259|dip:DIP-59358N	intact:EBI-15848589	psi-mi:radam10(display_long)	psi-mi:hla_staau(display_long)|uniprotkb:hly(gene name)|psi-mi:hly(display_short)|uniprotkb:hla(gene name synonym)|uniprotkb:Alpha-toxin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wilke et al. (2010)	pubmed:20624979|doi:10.1073/pnas.1001815107|imex:IM-16450	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:1280(staau)|taxid:1280(Staphylococcus aureus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15865281|imex:IM-16450-2|dip:DIP-187684E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding)|go:"GO:0044179"(hemolysis in another organism)|go:"GO:0090729"(toxin activity)|interpro:IPR003963(Bi-component toxin, staphylococci)|interpro:IPR005831(Aerolysin/haemolysin toxin, conserved site)|interpro:IPR016183(Leukocidin/porin)|interpro:IPR036435|rcsb pdb:3M2L|rcsb pdb:3M3R|rcsb pdb:3M4D|rcsb pdb:3M4E|rcsb pdb:4IDJ|rcsb pdb:4YHD|rcsb pdb:6U3T|rcsb pdb:6U49|rcsb pdb:6U4P|rcsb pdb:7AHL|rcsb pdb:7O1Q|reactome:R-HSA-9660826|reactome:R-HSA-844456|dip:DIP-59322N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	-	rogid:0BR0y0GDnhSuti8YNFYvf2RGbqo1280	-	false	-	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14672	uniprotkb:P09616	intact:EBI-1536151|uniprotkb:Q10742|uniprotkb:Q92650|uniprotkb:B4DU28|ensembl:ENSP00000260408	intact:EBI-15848589	psi-mi:ada10_human(display_long)|uniprotkb:ADAM10(gene name)|psi-mi:ADAM10(display_short)|uniprotkb:KUZ(gene name synonym)|uniprotkb:MADM(gene name synonym)|uniprotkb:Mammalian disintegrin-metalloprotease(gene name synonym)|uniprotkb:Kuzbanian protein homolog(gene name synonym)|uniprotkb:CDw156(gene name synonym)	psi-mi:hla_staau(display_long)|uniprotkb:hly(gene name)|psi-mi:hly(display_short)|uniprotkb:hla(gene name synonym)|uniprotkb:Alpha-toxin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wilke et al. (2010)	pubmed:20624979|doi:10.1073/pnas.1001815107|imex:IM-16450	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1280(staau)|taxid:1280(Staphylococcus aureus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15865300|imex:IM-16450-3|dip:DIP-187685E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001101.1|dip:DIP-39889N|ensembl:ENSG00000137845(gene)|ensembl:ENST00000260408(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042117"(monocyte activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0051089"(constitutive protein ectodomain proteolysis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090102"(cochlea development)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:1901342"(regulation of vasculature development)|go:"GO:1901998"(toxin transport)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR024079|interpro:IPR027053|interpro:IPR034025|interpro:IPR036436|mint:O14672|rcsb pdb:1M1I|rcsb pdb:6BDZ|rcsb pdb:6BE6|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-177929|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-381426|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-977225	go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding)|go:"GO:0044179"(hemolysis in another organism)|go:"GO:0090729"(toxin activity)|interpro:IPR003963(Bi-component toxin, staphylococci)|interpro:IPR005831(Aerolysin/haemolysin toxin, conserved site)|interpro:IPR016183(Leukocidin/porin)|interpro:IPR036435|rcsb pdb:3M2L|rcsb pdb:3M3R|rcsb pdb:3M4D|rcsb pdb:3M4E|rcsb pdb:4IDJ|rcsb pdb:4YHD|rcsb pdb:6U3T|rcsb pdb:6U49|rcsb pdb:6U4P|rcsb pdb:7AHL|rcsb pdb:7O1Q|reactome:R-HSA-9660826|reactome:R-HSA-844456|dip:DIP-59322N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:oaWIe6XWClYEFZKUARbeLsWRsu49606	rogid:0BR0y0GDnhSuti8YNFYvf2RGbqo1280	rigid:sDp3s/O0tNay/UXa/+T0JWSXwjo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)