#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q62172	uniprotkb:Q06A28	intact:EBI-8392197|uniprotkb:Q6NXH5|intact:MINT-4132030|uniprotkb:Q9CRE5|ensembl:ENSMUSP00000024905|ensembl:ENSMUSP00000129448	intact:EBI-9826498	psi-mi:rbp1_mouse(display_long)|uniprotkb:Ralbp1(gene name)|psi-mi:Ralbp1(display_short)|uniprotkb:Rip1(gene name synonym)|uniprotkb:Ral-interacting protein 1(gene name synonym)|uniprotkb:Dinitrophenyl S-glutathione ATPase(gene name synonym)	psi-mi:rir1_muhvs(display_long)|uniprotkb:RIR1(gene name)|psi-mi:RIR1(display_short)|uniprotkb:M45(gene name synonym)|uniprotkb:Viral inhibitor of RIP activation(gene name synonym)|uniprotkb:m45.1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mack et al. (2008)	pubmed:18287053|doi:10.1073/pnas.0800168105|imex:IM-9108	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10367(muhvs)|taxid:10367("Murid herpesvirus 1 (strain Smith)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15686952|imex:IM-9108-1|dip:DIP-59208E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185878.1|refseq:NP_033093.2|dip:DIP-29741N|ensembl:ENSMUSG00000024096(gene)|ensembl:ENSMUST00000024905(transcript)|ensembl:ENSMUST00000166543(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008559"(ABC-type xenobiotic transporter activity)|go:"GO:0015431"(ABC-type glutathione S-conjugate transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0055085"(transmembrane transport)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:1900753"(doxorubicin transport)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR039767|mint:Q62172|reactome:R-MMU-9013148|reactome:R-MMU-9013149	dip:DIP-29743N|go:"GO:0006260"(DNA replication)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR025735|interpro:IPR034716|interpro:IPR039718	psi-mi:"MI:0465"(dip)	comment:mint|function:"Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDC2 to switch off endocytosis, One of its substrates would be EPN1/Epsin(By similarity)"	crc64:BDDC93B8E71E40C7	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:lyOI0HV27cFQw8j+o+0yfrEh3K810090	rogid:mjrM2JaxmDuym0xoHSw4fE7NKc010367	rigid:rCrHCpFb9axg3sKeWST5FHoDlp0	false	-	ha tag:n-n|necessary binding region:977-1174	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62172	uniprotkb:Q06A28	intact:EBI-8392197|uniprotkb:Q6NXH5|intact:MINT-4132030|uniprotkb:Q9CRE5|ensembl:ENSMUSP00000024905|ensembl:ENSMUSP00000129448	intact:EBI-9826498	psi-mi:rbp1_mouse(display_long)|uniprotkb:Ralbp1(gene name)|psi-mi:Ralbp1(display_short)|uniprotkb:Rip1(gene name synonym)|uniprotkb:Ral-interacting protein 1(gene name synonym)|uniprotkb:Dinitrophenyl S-glutathione ATPase(gene name synonym)	psi-mi:rir1_muhvs(display_long)|uniprotkb:RIR1(gene name)|psi-mi:RIR1(display_short)|uniprotkb:M45(gene name synonym)|uniprotkb:Viral inhibitor of RIP activation(gene name synonym)|uniprotkb:m45.1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mack et al. (2008)	pubmed:18287053|doi:10.1073/pnas.0800168105|imex:IM-9108	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10367(muhvs)|taxid:10367("Murid herpesvirus 1 (strain Smith)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15686973|imex:IM-9108-3|dip:DIP-59208E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185878.1|refseq:NP_033093.2|dip:DIP-29741N|ensembl:ENSMUSG00000024096(gene)|ensembl:ENSMUST00000024905(transcript)|ensembl:ENSMUST00000166543(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008559"(ABC-type xenobiotic transporter activity)|go:"GO:0015431"(ABC-type glutathione S-conjugate transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0055085"(transmembrane transport)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:1900753"(doxorubicin transport)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR039767|mint:Q62172|reactome:R-MMU-9013148|reactome:R-MMU-9013149	dip:DIP-29743N|go:"GO:0006260"(DNA replication)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR025735|interpro:IPR034716|interpro:IPR039718	psi-mi:"MI:0465"(dip)	comment:mint|function:"Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDC2 to switch off endocytosis, One of its substrates would be EPN1/Epsin(By similarity)"	crc64:BDDC93B8E71E40C7	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:lyOI0HV27cFQw8j+o+0yfrEh3K810090	rogid:mjrM2JaxmDuym0xoHSw4fE7NKc010367	rigid:rCrHCpFb9axg3sKeWST5FHoDlp0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62172	uniprotkb:P62991	intact:EBI-8392197|uniprotkb:Q6NXH5|intact:MINT-4132030|uniprotkb:Q9CRE5|ensembl:ENSMUSP00000024905|ensembl:ENSMUSP00000129448	intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N	psi-mi:rbp1_mouse(display_long)|uniprotkb:Ralbp1(gene name)|psi-mi:Ralbp1(display_short)|uniprotkb:Rip1(gene name synonym)|uniprotkb:Ral-interacting protein 1(gene name synonym)|uniprotkb:Dinitrophenyl S-glutathione ATPase(gene name synonym)	psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mack et al. (2008)	pubmed:18287053|doi:10.1073/pnas.0800168105|imex:IM-9108	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15686990|imex:IM-9108-2|dip:DIP-59209E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185878.1|refseq:NP_033093.2|dip:DIP-29741N|ensembl:ENSMUSG00000024096(gene)|ensembl:ENSMUST00000024905(transcript)|ensembl:ENSMUST00000166543(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008559"(ABC-type xenobiotic transporter activity)|go:"GO:0015431"(ABC-type glutathione S-conjugate transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0055085"(transmembrane transport)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:1900753"(doxorubicin transport)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR039767|mint:Q62172|reactome:R-MMU-9013148|reactome:R-MMU-9013149	interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K	psi-mi:"MI:0465"(dip)	comment:mint|function:"Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDC2 to switch off endocytosis, One of its substrates would be EPN1/Epsin(By similarity)"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/15	rogid:lyOI0HV27cFQw8j+o+0yfrEh3K810090	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090	rigid:J3mA9ppKKqyPgtIwmvUyrbGRE/I	false	myc tag:n-n	ha tag:0-0	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)