#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01033	uniprotkb:P08962	intact:EBI-712536|ensembl:ENSP00000218388|uniprotkb:Q14252|uniprotkb:Q9UCU1	intact:EBI-762053|uniprotkb:Q5TZP3|uniprotkb:Q9UCG6|uniprotkb:Q8N6Z9|uniprotkb:F8VZE2|ensembl:ENSP00000257857|ensembl:ENSP00000393502|ensembl:ENSP00000447730|ensembl:ENSP00000449337	psi-mi:timp1_human(display_long)|uniprotkb:Tissue inhibitor of metalloproteinases 1(gene name synonym)|uniprotkb:Erythroid-potentiating activity(gene name synonym)|uniprotkb:Fibroblast collagenase inhibitor(gene name synonym)|uniprotkb:TIMP1(gene name)|psi-mi:TIMP1(display_short)|uniprotkb:CLGI(gene name synonym)|uniprotkb:TIMP(gene name synonym)	psi-mi:cd63_human(display_long)|uniprotkb:Melanoma-associated antigen ME491(gene name synonym)|uniprotkb:Ocular melanoma-associated antigen(gene name synonym)|uniprotkb:OMA81H(gene name synonym)|uniprotkb:Granulophysin(gene name synonym)|uniprotkb:Tetraspanin-30(gene name synonym)|uniprotkb:Lysosomal-associated membrane protein 3(gene name synonym)|uniprotkb:CD63(gene name)|psi-mi:CD63(display_short)|uniprotkb:MLA1(gene name synonym)|uniprotkb:TSPAN30(gene name synonym)|uniprotkb:Lysosome integral membrane protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2017)	pubmed:28030805|imex:IM-22622	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9679503|imex:IM-22622-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1905049"(negative regulation of metallopeptidase activity)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015611(Tissue inhibitor of metalloprotease 1)|interpro:IPR027465|interpro:IPR030490|mint:P01033|rcsb pdb:1D2B|rcsb pdb:1LQN|rcsb pdb:1OO9|rcsb pdb:2J0T|rcsb pdb:3MA2|rcsb pdb:3V96|rcsb pdb:6MAV|rcsb pdb:6N9D|reactome:R-HSA-114608|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8957275|rcsb pdb:1UEA|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000102265(gene)|ensembl:ENST00000218388(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0007568"(aging)|go:"GO:0005125"(cytokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|refseq:NP_003245.1|dip:DIP-1107N	refseq:NP_001771.1|refseq:NP_001244330.1|refseq:NP_001244318.1|refseq:NP_001244319.1|refseq:NP_001244320.1|refseq:NP_001244329.1|refseq:NP_001254627.1|refseq:NP_001244321.1|ensembl:ENSG00000135404(gene)|ensembl:ENST00000257857(transcript)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|interpro:IPR042028|mint:P08962|reactome:R-HSA-114608|reactome:R-HSA-6798695|go:"GO:0097487"(multivesicular body, internal vesicle)|ensembl:ENST00000420846(transcript)|ensembl:ENST00000549117(transcript)|ensembl:ENST00000552692(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016477"(cell migration)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048757"(pigment granule maturation)|go:"GO:0070062"(extracellular exosome)	-	-	-	figure legend:Fig1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-panc1)|taxid:9606(Homo sapiens pancreatic carcinoma cell line PANC-1)	-	2014/07/23	2019/05/09	rogid:P8NrZDC/GnDTkXsOSI1eCUEK1nE9606	rogid:stCGi5kkTMIdO84qSwjmjpUwwvs9606	intact-crc:1B542FF88E007116|rigid:ROAvpXo3LRNG9ov0DS4x70Duuk8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01033	uniprotkb:P27701	intact:EBI-712536|ensembl:ENSP00000218388|uniprotkb:Q14252|uniprotkb:Q9UCU1	intact:EBI-682379|uniprotkb:Q7Z2D4|uniprotkb:D3DQN6|intact:EBI-726186|uniprotkb:E9PC70|uniprotkb:Q7Z5N2|ensembl:ENSP00000227155	psi-mi:timp1_human(display_long)|uniprotkb:Tissue inhibitor of metalloproteinases 1(gene name synonym)|uniprotkb:Erythroid-potentiating activity(gene name synonym)|uniprotkb:Fibroblast collagenase inhibitor(gene name synonym)|uniprotkb:TIMP1(gene name)|psi-mi:TIMP1(display_short)|uniprotkb:CLGI(gene name synonym)|uniprotkb:TIMP(gene name synonym)	psi-mi:cd82_human(display_long)|uniprotkb:Inducible membrane protein R2(gene name synonym)|uniprotkb:C33 antigen(gene name synonym)|uniprotkb:IA4(gene name synonym)|uniprotkb:Metastasis suppressor Kangai-1(gene name synonym)|uniprotkb:Suppressor of tumorigenicity 6 protein(gene name synonym)|uniprotkb:Tetraspanin-27(gene name synonym)|uniprotkb:CD82(gene name)|psi-mi:CD82(display_short)|uniprotkb:KAI1(gene name synonym)|uniprotkb:SAR2(gene name synonym)|uniprotkb:TSPAN27(gene name synonym)|uniprotkb:ST6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2017)	pubmed:28030805|imex:IM-22622	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9679503|imex:IM-22622-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1905049"(negative regulation of metallopeptidase activity)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015611(Tissue inhibitor of metalloprotease 1)|interpro:IPR027465|interpro:IPR030490|mint:P01033|rcsb pdb:1D2B|rcsb pdb:1LQN|rcsb pdb:1OO9|rcsb pdb:2J0T|rcsb pdb:3MA2|rcsb pdb:3V96|rcsb pdb:6MAV|rcsb pdb:6N9D|reactome:R-HSA-114608|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8957275|rcsb pdb:1UEA|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000102265(gene)|ensembl:ENST00000218388(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0007568"(aging)|go:"GO:0005125"(cytokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|refseq:NP_003245.1|dip:DIP-1107N	refseq:NP_001020015.1|refseq:NP_002222.1|refseq:XP_006718286.1|ensembl:ENSG00000085117(gene)|ensembl:ENST00000227155(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P27701	-	-	-	figure legend:Fig1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-panc1)|taxid:9606(Homo sapiens pancreatic carcinoma cell line PANC-1)	-	2014/07/23	2019/05/09	rogid:P8NrZDC/GnDTkXsOSI1eCUEK1nE9606	rogid:8Ow5hrE81Uf1Lqyb9lRIUg2Ng5I9606	intact-crc:1B542FF88E007116|rigid:ROAvpXo3LRNG9ov0DS4x70Duuk8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01033	uniprotkb:P27701	intact:EBI-712536|ensembl:ENSP00000218388|uniprotkb:Q14252|uniprotkb:Q9UCU1	intact:EBI-682379|uniprotkb:Q7Z2D4|uniprotkb:D3DQN6|intact:EBI-726186|uniprotkb:E9PC70|uniprotkb:Q7Z5N2|ensembl:ENSP00000227155	psi-mi:timp1_human(display_long)|uniprotkb:Tissue inhibitor of metalloproteinases 1(gene name synonym)|uniprotkb:Erythroid-potentiating activity(gene name synonym)|uniprotkb:Fibroblast collagenase inhibitor(gene name synonym)|uniprotkb:TIMP1(gene name)|psi-mi:TIMP1(display_short)|uniprotkb:CLGI(gene name synonym)|uniprotkb:TIMP(gene name synonym)	psi-mi:cd82_human(display_long)|uniprotkb:Inducible membrane protein R2(gene name synonym)|uniprotkb:C33 antigen(gene name synonym)|uniprotkb:IA4(gene name synonym)|uniprotkb:Metastasis suppressor Kangai-1(gene name synonym)|uniprotkb:Suppressor of tumorigenicity 6 protein(gene name synonym)|uniprotkb:Tetraspanin-27(gene name synonym)|uniprotkb:CD82(gene name)|psi-mi:CD82(display_short)|uniprotkb:KAI1(gene name synonym)|uniprotkb:SAR2(gene name synonym)|uniprotkb:TSPAN27(gene name synonym)|uniprotkb:ST6(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zhang et al. (2017)	pubmed:28030805|imex:IM-22622	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9679823|imex:IM-22622-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1905049"(negative regulation of metallopeptidase activity)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015611(Tissue inhibitor of metalloprotease 1)|interpro:IPR027465|interpro:IPR030490|mint:P01033|rcsb pdb:1D2B|rcsb pdb:1LQN|rcsb pdb:1OO9|rcsb pdb:2J0T|rcsb pdb:3MA2|rcsb pdb:3V96|rcsb pdb:6MAV|rcsb pdb:6N9D|reactome:R-HSA-114608|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8957275|rcsb pdb:1UEA|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000102265(gene)|ensembl:ENST00000218388(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0007568"(aging)|go:"GO:0005125"(cytokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|refseq:NP_003245.1|dip:DIP-1107N	refseq:NP_001020015.1|refseq:NP_002222.1|refseq:XP_006718286.1|ensembl:ENSG00000085117(gene)|ensembl:ENST00000227155(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P27701	go:"GO:0009986"(cell surface)	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-panc1)|taxid:9606(Homo sapiens pancreatic carcinoma cell line PANC-1)	-	2014/07/23	2014/10/16	rogid:P8NrZDC/GnDTkXsOSI1eCUEK1nE9606	rogid:8Ow5hrE81Uf1Lqyb9lRIUg2Ng5I9606	intact-crc:F9D1BA9A753D0C2D|rigid:u07e6CvcU38+YOfC2LjESH/hH/8	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P27701	uniprotkb:P01033	intact:EBI-682379|uniprotkb:Q7Z2D4|uniprotkb:D3DQN6|intact:EBI-726186|uniprotkb:E9PC70|uniprotkb:Q7Z5N2|ensembl:ENSP00000227155	intact:EBI-712536|ensembl:ENSP00000218388|uniprotkb:Q14252|uniprotkb:Q9UCU1	psi-mi:cd82_human(display_long)|uniprotkb:Inducible membrane protein R2(gene name synonym)|uniprotkb:C33 antigen(gene name synonym)|uniprotkb:IA4(gene name synonym)|uniprotkb:Metastasis suppressor Kangai-1(gene name synonym)|uniprotkb:Suppressor of tumorigenicity 6 protein(gene name synonym)|uniprotkb:Tetraspanin-27(gene name synonym)|uniprotkb:CD82(gene name)|psi-mi:CD82(display_short)|uniprotkb:KAI1(gene name synonym)|uniprotkb:SAR2(gene name synonym)|uniprotkb:TSPAN27(gene name synonym)|uniprotkb:ST6(gene name synonym)	psi-mi:timp1_human(display_long)|uniprotkb:Tissue inhibitor of metalloproteinases 1(gene name synonym)|uniprotkb:Erythroid-potentiating activity(gene name synonym)|uniprotkb:Fibroblast collagenase inhibitor(gene name synonym)|uniprotkb:TIMP1(gene name)|psi-mi:TIMP1(display_short)|uniprotkb:CLGI(gene name synonym)|uniprotkb:TIMP(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zhang et al. (2017)	pubmed:28030805|imex:IM-22622	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9679833|imex:IM-22622-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020015.1|refseq:NP_002222.1|refseq:XP_006718286.1|ensembl:ENSG00000085117(gene)|ensembl:ENST00000227155(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P27701	go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1905049"(negative regulation of metallopeptidase activity)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015611(Tissue inhibitor of metalloprotease 1)|interpro:IPR027465|interpro:IPR030490|mint:P01033|rcsb pdb:1D2B|rcsb pdb:1LQN|rcsb pdb:1OO9|rcsb pdb:2J0T|rcsb pdb:3MA2|rcsb pdb:3V96|rcsb pdb:6MAV|rcsb pdb:6N9D|reactome:R-HSA-114608|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8957275|rcsb pdb:1UEA|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000102265(gene)|ensembl:ENST00000218388(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0007568"(aging)|go:"GO:0005125"(cytokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|refseq:NP_003245.1|dip:DIP-1107N	go:"GO:0009986"(cell surface)	-	-	figure legend:2A|comment:This colocalization was also found in a MCF7 cell line overexpressing TIM1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2014/07/23	2014/10/16	rogid:8Ow5hrE81Uf1Lqyb9lRIUg2Ng5I9606	rogid:P8NrZDC/GnDTkXsOSI1eCUEK1nE9606	intact-crc:615E778861AF095B|rigid:u07e6CvcU38+YOfC2LjESH/hH/8	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P01033	uniprotkb:P27701	intact:EBI-712536|ensembl:ENSP00000218388|uniprotkb:Q14252|uniprotkb:Q9UCU1	intact:EBI-682379|uniprotkb:Q7Z2D4|uniprotkb:D3DQN6|intact:EBI-726186|uniprotkb:E9PC70|uniprotkb:Q7Z5N2|ensembl:ENSP00000227155	psi-mi:timp1_human(display_long)|uniprotkb:Tissue inhibitor of metalloproteinases 1(gene name synonym)|uniprotkb:Erythroid-potentiating activity(gene name synonym)|uniprotkb:Fibroblast collagenase inhibitor(gene name synonym)|uniprotkb:TIMP1(gene name)|psi-mi:TIMP1(display_short)|uniprotkb:CLGI(gene name synonym)|uniprotkb:TIMP(gene name synonym)	psi-mi:cd82_human(display_long)|uniprotkb:Inducible membrane protein R2(gene name synonym)|uniprotkb:C33 antigen(gene name synonym)|uniprotkb:IA4(gene name synonym)|uniprotkb:Metastasis suppressor Kangai-1(gene name synonym)|uniprotkb:Suppressor of tumorigenicity 6 protein(gene name synonym)|uniprotkb:Tetraspanin-27(gene name synonym)|uniprotkb:CD82(gene name)|psi-mi:CD82(display_short)|uniprotkb:KAI1(gene name synonym)|uniprotkb:SAR2(gene name synonym)|uniprotkb:TSPAN27(gene name synonym)|uniprotkb:ST6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2017)	pubmed:28030805|imex:IM-22622	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9679494|imex:IM-22622-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1905049"(negative regulation of metallopeptidase activity)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015611(Tissue inhibitor of metalloprotease 1)|interpro:IPR027465|interpro:IPR030490|mint:P01033|rcsb pdb:1D2B|rcsb pdb:1LQN|rcsb pdb:1OO9|rcsb pdb:2J0T|rcsb pdb:3MA2|rcsb pdb:3V96|rcsb pdb:6MAV|rcsb pdb:6N9D|reactome:R-HSA-114608|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8957275|rcsb pdb:1UEA|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000102265(gene)|ensembl:ENST00000218388(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0007568"(aging)|go:"GO:0005125"(cytokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|refseq:NP_003245.1|dip:DIP-1107N	refseq:NP_001020015.1|refseq:NP_002222.1|refseq:XP_006718286.1|ensembl:ENSG00000085117(gene)|ensembl:ENST00000227155(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P27701	-	-	-	figure legend:"1A(I,II,III)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-panc1)|taxid:9606(Homo sapiens pancreatic carcinoma cell line PANC-1)	-	2014/07/23	2014/10/16	rogid:P8NrZDC/GnDTkXsOSI1eCUEK1nE9606	rogid:8Ow5hrE81Uf1Lqyb9lRIUg2Ng5I9606	intact-crc:7EC07242C9BADC44|rigid:ROAvpXo3LRNG9ov0DS4x70Duuk8	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P01033	uniprotkb:P08962	intact:EBI-712536|ensembl:ENSP00000218388|uniprotkb:Q14252|uniprotkb:Q9UCU1	intact:EBI-762053|uniprotkb:Q5TZP3|uniprotkb:Q9UCG6|uniprotkb:Q8N6Z9|uniprotkb:F8VZE2|ensembl:ENSP00000257857|ensembl:ENSP00000393502|ensembl:ENSP00000447730|ensembl:ENSP00000449337	psi-mi:timp1_human(display_long)|uniprotkb:Tissue inhibitor of metalloproteinases 1(gene name synonym)|uniprotkb:Erythroid-potentiating activity(gene name synonym)|uniprotkb:Fibroblast collagenase inhibitor(gene name synonym)|uniprotkb:TIMP1(gene name)|psi-mi:TIMP1(display_short)|uniprotkb:CLGI(gene name synonym)|uniprotkb:TIMP(gene name synonym)	psi-mi:cd63_human(display_long)|uniprotkb:Melanoma-associated antigen ME491(gene name synonym)|uniprotkb:Ocular melanoma-associated antigen(gene name synonym)|uniprotkb:OMA81H(gene name synonym)|uniprotkb:Granulophysin(gene name synonym)|uniprotkb:Tetraspanin-30(gene name synonym)|uniprotkb:Lysosomal-associated membrane protein 3(gene name synonym)|uniprotkb:CD63(gene name)|psi-mi:CD63(display_short)|uniprotkb:MLA1(gene name synonym)|uniprotkb:TSPAN30(gene name synonym)|uniprotkb:Lysosome integral membrane protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2017)	pubmed:28030805|imex:IM-22622	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9679494|imex:IM-22622-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1905049"(negative regulation of metallopeptidase activity)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015611(Tissue inhibitor of metalloprotease 1)|interpro:IPR027465|interpro:IPR030490|mint:P01033|rcsb pdb:1D2B|rcsb pdb:1LQN|rcsb pdb:1OO9|rcsb pdb:2J0T|rcsb pdb:3MA2|rcsb pdb:3V96|rcsb pdb:6MAV|rcsb pdb:6N9D|reactome:R-HSA-114608|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8957275|rcsb pdb:1UEA|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000102265(gene)|ensembl:ENST00000218388(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0007568"(aging)|go:"GO:0005125"(cytokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|refseq:NP_003245.1|dip:DIP-1107N	refseq:NP_001771.1|refseq:NP_001244330.1|refseq:NP_001244318.1|refseq:NP_001244319.1|refseq:NP_001244320.1|refseq:NP_001244329.1|refseq:NP_001254627.1|refseq:NP_001244321.1|ensembl:ENSG00000135404(gene)|ensembl:ENST00000257857(transcript)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|interpro:IPR042028|mint:P08962|reactome:R-HSA-114608|reactome:R-HSA-6798695|go:"GO:0097487"(multivesicular body, internal vesicle)|ensembl:ENST00000420846(transcript)|ensembl:ENST00000549117(transcript)|ensembl:ENST00000552692(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016477"(cell migration)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048757"(pigment granule maturation)|go:"GO:0070062"(extracellular exosome)	-	-	-	figure legend:"1A(I,II,III)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-panc1)|taxid:9606(Homo sapiens pancreatic carcinoma cell line PANC-1)	-	2014/07/23	2014/10/16	rogid:P8NrZDC/GnDTkXsOSI1eCUEK1nE9606	rogid:stCGi5kkTMIdO84qSwjmjpUwwvs9606	intact-crc:7EC07242C9BADC44|rigid:ROAvpXo3LRNG9ov0DS4x70Duuk8	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P01033	uniprotkb:P27701	intact:EBI-712536|ensembl:ENSP00000218388|uniprotkb:Q14252|uniprotkb:Q9UCU1	intact:EBI-682379|uniprotkb:Q7Z2D4|uniprotkb:D3DQN6|intact:EBI-726186|uniprotkb:E9PC70|uniprotkb:Q7Z5N2|ensembl:ENSP00000227155	psi-mi:timp1_human(display_long)|uniprotkb:Tissue inhibitor of metalloproteinases 1(gene name synonym)|uniprotkb:Erythroid-potentiating activity(gene name synonym)|uniprotkb:Fibroblast collagenase inhibitor(gene name synonym)|uniprotkb:TIMP1(gene name)|psi-mi:TIMP1(display_short)|uniprotkb:CLGI(gene name synonym)|uniprotkb:TIMP(gene name synonym)	psi-mi:cd82_human(display_long)|uniprotkb:Inducible membrane protein R2(gene name synonym)|uniprotkb:C33 antigen(gene name synonym)|uniprotkb:IA4(gene name synonym)|uniprotkb:Metastasis suppressor Kangai-1(gene name synonym)|uniprotkb:Suppressor of tumorigenicity 6 protein(gene name synonym)|uniprotkb:Tetraspanin-27(gene name synonym)|uniprotkb:CD82(gene name)|psi-mi:CD82(display_short)|uniprotkb:KAI1(gene name synonym)|uniprotkb:SAR2(gene name synonym)|uniprotkb:TSPAN27(gene name synonym)|uniprotkb:ST6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Zhang et al. (2017)	pubmed:28030805|imex:IM-22622	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9679526|imex:IM-22622-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1905049"(negative regulation of metallopeptidase activity)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015611(Tissue inhibitor of metalloprotease 1)|interpro:IPR027465|interpro:IPR030490|mint:P01033|rcsb pdb:1D2B|rcsb pdb:1LQN|rcsb pdb:1OO9|rcsb pdb:2J0T|rcsb pdb:3MA2|rcsb pdb:3V96|rcsb pdb:6MAV|rcsb pdb:6N9D|reactome:R-HSA-114608|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8957275|rcsb pdb:1UEA|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000102265(gene)|ensembl:ENST00000218388(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0007568"(aging)|go:"GO:0005125"(cytokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|refseq:NP_003245.1|dip:DIP-1107N	refseq:NP_001020015.1|refseq:NP_002222.1|refseq:XP_006718286.1|ensembl:ENSG00000085117(gene)|ensembl:ENST00000227155(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P27701	-	-	-	figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/23	2014/10/16	rogid:P8NrZDC/GnDTkXsOSI1eCUEK1nE9606	rogid:8Ow5hrE81Uf1Lqyb9lRIUg2Ng5I9606	intact-crc:5B1E52371146693D|rigid:u07e6CvcU38+YOfC2LjESH/hH/8	false	sufficient binding region:24-204	sufficient binding region:111-228|his tag:n-n|tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P01033	uniprotkb:P01033	intact:EBI-712536|ensembl:ENSP00000218388|uniprotkb:Q14252|uniprotkb:Q9UCU1	intact:EBI-712536|ensembl:ENSP00000218388|uniprotkb:Q14252|uniprotkb:Q9UCU1	psi-mi:timp1_human(display_long)|uniprotkb:Tissue inhibitor of metalloproteinases 1(gene name synonym)|uniprotkb:Erythroid-potentiating activity(gene name synonym)|uniprotkb:Fibroblast collagenase inhibitor(gene name synonym)|uniprotkb:TIMP1(gene name)|psi-mi:TIMP1(display_short)|uniprotkb:CLGI(gene name synonym)|uniprotkb:TIMP(gene name synonym)	psi-mi:timp1_human(display_long)|uniprotkb:Tissue inhibitor of metalloproteinases 1(gene name synonym)|uniprotkb:Erythroid-potentiating activity(gene name synonym)|uniprotkb:Fibroblast collagenase inhibitor(gene name synonym)|uniprotkb:TIMP1(gene name)|psi-mi:TIMP1(display_short)|uniprotkb:CLGI(gene name synonym)|uniprotkb:TIMP(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Zhang et al. (2017)	pubmed:28030805|imex:IM-22622	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9679538|imex:IM-22622-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1905049"(negative regulation of metallopeptidase activity)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015611(Tissue inhibitor of metalloprotease 1)|interpro:IPR027465|interpro:IPR030490|mint:P01033|rcsb pdb:1D2B|rcsb pdb:1LQN|rcsb pdb:1OO9|rcsb pdb:2J0T|rcsb pdb:3MA2|rcsb pdb:3V96|rcsb pdb:6MAV|rcsb pdb:6N9D|reactome:R-HSA-114608|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8957275|rcsb pdb:1UEA|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000102265(gene)|ensembl:ENST00000218388(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0007568"(aging)|go:"GO:0005125"(cytokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|refseq:NP_003245.1|dip:DIP-1107N	go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1905049"(negative regulation of metallopeptidase activity)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015611(Tissue inhibitor of metalloprotease 1)|interpro:IPR027465|interpro:IPR030490|mint:P01033|rcsb pdb:1D2B|rcsb pdb:1LQN|rcsb pdb:1OO9|rcsb pdb:2J0T|rcsb pdb:3MA2|rcsb pdb:3V96|rcsb pdb:6MAV|rcsb pdb:6N9D|reactome:R-HSA-114608|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8957275|rcsb pdb:1UEA|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000102265(gene)|ensembl:ENST00000218388(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0007568"(aging)|go:"GO:0005125"(cytokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|refseq:NP_003245.1|dip:DIP-1107N	-	-	-	figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/23	2015/04/08	rogid:P8NrZDC/GnDTkXsOSI1eCUEK1nE9606	rogid:P8NrZDC/GnDTkXsOSI1eCUEK1nE9606	intact-crc:34542F557D2AFA19|rigid:iGBmu+6cgxAdb6dsrvywkoK+iRg	false	sufficient binding region:24-204	sufficient binding region:24-204	2	0	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P01033	uniprotkb:P27701	intact:EBI-712536|ensembl:ENSP00000218388|uniprotkb:Q14252|uniprotkb:Q9UCU1	intact:EBI-682379|uniprotkb:Q7Z2D4|uniprotkb:D3DQN6|intact:EBI-726186|uniprotkb:E9PC70|uniprotkb:Q7Z5N2|ensembl:ENSP00000227155	psi-mi:timp1_human(display_long)|uniprotkb:Tissue inhibitor of metalloproteinases 1(gene name synonym)|uniprotkb:Erythroid-potentiating activity(gene name synonym)|uniprotkb:Fibroblast collagenase inhibitor(gene name synonym)|uniprotkb:TIMP1(gene name)|psi-mi:TIMP1(display_short)|uniprotkb:CLGI(gene name synonym)|uniprotkb:TIMP(gene name synonym)	psi-mi:cd82_human(display_long)|uniprotkb:Inducible membrane protein R2(gene name synonym)|uniprotkb:C33 antigen(gene name synonym)|uniprotkb:IA4(gene name synonym)|uniprotkb:Metastasis suppressor Kangai-1(gene name synonym)|uniprotkb:Suppressor of tumorigenicity 6 protein(gene name synonym)|uniprotkb:Tetraspanin-27(gene name synonym)|uniprotkb:CD82(gene name)|psi-mi:CD82(display_short)|uniprotkb:KAI1(gene name synonym)|uniprotkb:SAR2(gene name synonym)|uniprotkb:TSPAN27(gene name synonym)|uniprotkb:ST6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2017)	pubmed:28030805|imex:IM-22622	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9679669|imex:IM-22622-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1905049"(negative regulation of metallopeptidase activity)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015611(Tissue inhibitor of metalloprotease 1)|interpro:IPR027465|interpro:IPR030490|mint:P01033|rcsb pdb:1D2B|rcsb pdb:1LQN|rcsb pdb:1OO9|rcsb pdb:2J0T|rcsb pdb:3MA2|rcsb pdb:3V96|rcsb pdb:6MAV|rcsb pdb:6N9D|reactome:R-HSA-114608|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8957275|rcsb pdb:1UEA|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000102265(gene)|ensembl:ENST00000218388(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0007568"(aging)|go:"GO:0005125"(cytokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|refseq:NP_003245.1|dip:DIP-1107N	refseq:NP_001020015.1|refseq:NP_002222.1|refseq:XP_006718286.1|ensembl:ENSG00000085117(gene)|ensembl:ENST00000227155(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P27701	-	-	-	figure legend:3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/23	2014/10/16	rogid:P8NrZDC/GnDTkXsOSI1eCUEK1nE9606	rogid:8Ow5hrE81Uf1Lqyb9lRIUg2Ng5I9606	intact-crc:906B4C584B64E3BA|rigid:u07e6CvcU38+YOfC2LjESH/hH/8	false	sufficient binding region:24-204	tag:c-c|his tag:n-n|sufficient binding region:111-228|125i radiolabel:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P01033	uniprotkb:P27701	intact:EBI-712536|ensembl:ENSP00000218388|uniprotkb:Q14252|uniprotkb:Q9UCU1	intact:EBI-682379|uniprotkb:Q7Z2D4|uniprotkb:D3DQN6|intact:EBI-726186|uniprotkb:E9PC70|uniprotkb:Q7Z5N2|ensembl:ENSP00000227155	psi-mi:timp1_human(display_long)|uniprotkb:Tissue inhibitor of metalloproteinases 1(gene name synonym)|uniprotkb:Erythroid-potentiating activity(gene name synonym)|uniprotkb:Fibroblast collagenase inhibitor(gene name synonym)|uniprotkb:TIMP1(gene name)|psi-mi:TIMP1(display_short)|uniprotkb:CLGI(gene name synonym)|uniprotkb:TIMP(gene name synonym)	psi-mi:cd82_human(display_long)|uniprotkb:Inducible membrane protein R2(gene name synonym)|uniprotkb:C33 antigen(gene name synonym)|uniprotkb:IA4(gene name synonym)|uniprotkb:Metastasis suppressor Kangai-1(gene name synonym)|uniprotkb:Suppressor of tumorigenicity 6 protein(gene name synonym)|uniprotkb:Tetraspanin-27(gene name synonym)|uniprotkb:CD82(gene name)|psi-mi:CD82(display_short)|uniprotkb:KAI1(gene name synonym)|uniprotkb:SAR2(gene name synonym)|uniprotkb:TSPAN27(gene name synonym)|uniprotkb:ST6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2017)	pubmed:28030805|imex:IM-22622	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9679669|imex:IM-22622-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1905049"(negative regulation of metallopeptidase activity)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015611(Tissue inhibitor of metalloprotease 1)|interpro:IPR027465|interpro:IPR030490|mint:P01033|rcsb pdb:1D2B|rcsb pdb:1LQN|rcsb pdb:1OO9|rcsb pdb:2J0T|rcsb pdb:3MA2|rcsb pdb:3V96|rcsb pdb:6MAV|rcsb pdb:6N9D|reactome:R-HSA-114608|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8957275|rcsb pdb:1UEA|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000102265(gene)|ensembl:ENST00000218388(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0007568"(aging)|go:"GO:0005125"(cytokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|refseq:NP_003245.1|dip:DIP-1107N	refseq:NP_001020015.1|refseq:NP_002222.1|refseq:XP_006718286.1|ensembl:ENSG00000085117(gene)|ensembl:ENST00000227155(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P27701	-	-	-	figure legend:3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/23	2014/10/16	rogid:P8NrZDC/GnDTkXsOSI1eCUEK1nE9606	rogid:8Ow5hrE81Uf1Lqyb9lRIUg2Ng5I9606	intact-crc:906B4C584B64E3BA|rigid:u07e6CvcU38+YOfC2LjESH/hH/8	false	sufficient binding region:24-204	tag:c-c|sufficient binding region:111-228|his tag:n-n	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P27701	uniprotkb:P01033	intact:EBI-682379|uniprotkb:Q7Z2D4|uniprotkb:D3DQN6|intact:EBI-726186|uniprotkb:E9PC70|uniprotkb:Q7Z5N2|ensembl:ENSP00000227155	intact:EBI-712536|ensembl:ENSP00000218388|uniprotkb:Q14252|uniprotkb:Q9UCU1	psi-mi:cd82_human(display_long)|uniprotkb:Inducible membrane protein R2(gene name synonym)|uniprotkb:C33 antigen(gene name synonym)|uniprotkb:IA4(gene name synonym)|uniprotkb:Metastasis suppressor Kangai-1(gene name synonym)|uniprotkb:Suppressor of tumorigenicity 6 protein(gene name synonym)|uniprotkb:Tetraspanin-27(gene name synonym)|uniprotkb:CD82(gene name)|psi-mi:CD82(display_short)|uniprotkb:KAI1(gene name synonym)|uniprotkb:SAR2(gene name synonym)|uniprotkb:TSPAN27(gene name synonym)|uniprotkb:ST6(gene name synonym)	psi-mi:timp1_human(display_long)|uniprotkb:Tissue inhibitor of metalloproteinases 1(gene name synonym)|uniprotkb:Erythroid-potentiating activity(gene name synonym)|uniprotkb:Fibroblast collagenase inhibitor(gene name synonym)|uniprotkb:TIMP1(gene name)|psi-mi:TIMP1(display_short)|uniprotkb:CLGI(gene name synonym)|uniprotkb:TIMP(gene name synonym)	psi-mi:"MI:0872"(atomic force microscopy)	Zhang et al. (2017)	pubmed:28030805|imex:IM-22622	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9679784|imex:IM-22622-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020015.1|refseq:NP_002222.1|refseq:XP_006718286.1|ensembl:ENSG00000085117(gene)|ensembl:ENST00000227155(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P27701	go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1905049"(negative regulation of metallopeptidase activity)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015611(Tissue inhibitor of metalloprotease 1)|interpro:IPR027465|interpro:IPR030490|mint:P01033|rcsb pdb:1D2B|rcsb pdb:1LQN|rcsb pdb:1OO9|rcsb pdb:2J0T|rcsb pdb:3MA2|rcsb pdb:3V96|rcsb pdb:6MAV|rcsb pdb:6N9D|reactome:R-HSA-114608|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8957275|rcsb pdb:1UEA|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000102265(gene)|ensembl:ENST00000218388(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0007568"(aging)|go:"GO:0005125"(cytokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|refseq:NP_003245.1|dip:DIP-1107N	-	-	-	figure legend:1D|comment:Dissociation force = 35 pN|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/23	2014/10/16	rogid:8Ow5hrE81Uf1Lqyb9lRIUg2Ng5I9606	rogid:P8NrZDC/GnDTkXsOSI1eCUEK1nE9606	intact-crc:32424626BABF7851|rigid:u07e6CvcU38+YOfC2LjESH/hH/8	false	sufficient binding region:111-228|his tag:n-n|tag:c-c	sufficient binding region:24-204	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08962	uniprotkb:P01033	intact:EBI-762053|uniprotkb:Q5TZP3|uniprotkb:Q9UCG6|uniprotkb:Q8N6Z9|uniprotkb:F8VZE2|ensembl:ENSP00000257857|ensembl:ENSP00000393502|ensembl:ENSP00000447730|ensembl:ENSP00000449337	intact:EBI-712536|ensembl:ENSP00000218388|uniprotkb:Q14252|uniprotkb:Q9UCU1	psi-mi:cd63_human(display_long)|uniprotkb:Melanoma-associated antigen ME491(gene name synonym)|uniprotkb:Ocular melanoma-associated antigen(gene name synonym)|uniprotkb:OMA81H(gene name synonym)|uniprotkb:Granulophysin(gene name synonym)|uniprotkb:Tetraspanin-30(gene name synonym)|uniprotkb:Lysosomal-associated membrane protein 3(gene name synonym)|uniprotkb:CD63(gene name)|psi-mi:CD63(display_short)|uniprotkb:MLA1(gene name synonym)|uniprotkb:TSPAN30(gene name synonym)|uniprotkb:Lysosome integral membrane protein 1(gene name synonym)	psi-mi:timp1_human(display_long)|uniprotkb:Tissue inhibitor of metalloproteinases 1(gene name synonym)|uniprotkb:Erythroid-potentiating activity(gene name synonym)|uniprotkb:Fibroblast collagenase inhibitor(gene name synonym)|uniprotkb:TIMP1(gene name)|psi-mi:TIMP1(display_short)|uniprotkb:CLGI(gene name synonym)|uniprotkb:TIMP(gene name synonym)	psi-mi:"MI:0872"(atomic force microscopy)	Zhang et al. (2017)	pubmed:28030805|imex:IM-22622	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9679797|imex:IM-22622-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001771.1|refseq:NP_001244330.1|refseq:NP_001244318.1|refseq:NP_001244319.1|refseq:NP_001244320.1|refseq:NP_001244329.1|refseq:NP_001254627.1|refseq:NP_001244321.1|ensembl:ENSG00000135404(gene)|ensembl:ENST00000257857(transcript)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|interpro:IPR042028|mint:P08962|reactome:R-HSA-114608|reactome:R-HSA-6798695|go:"GO:0097487"(multivesicular body, internal vesicle)|ensembl:ENST00000420846(transcript)|ensembl:ENST00000549117(transcript)|ensembl:ENST00000552692(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016477"(cell migration)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048757"(pigment granule maturation)|go:"GO:0070062"(extracellular exosome)	go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1905049"(negative regulation of metallopeptidase activity)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015611(Tissue inhibitor of metalloprotease 1)|interpro:IPR027465|interpro:IPR030490|mint:P01033|rcsb pdb:1D2B|rcsb pdb:1LQN|rcsb pdb:1OO9|rcsb pdb:2J0T|rcsb pdb:3MA2|rcsb pdb:3V96|rcsb pdb:6MAV|rcsb pdb:6N9D|reactome:R-HSA-114608|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8957275|rcsb pdb:1UEA|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000102265(gene)|ensembl:ENST00000218388(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0007568"(aging)|go:"GO:0005125"(cytokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|refseq:NP_003245.1|dip:DIP-1107N	-	-	-	figure legend:3D|comment:Average dissociation force = 80 pN|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/23	2014/10/16	rogid:stCGi5kkTMIdO84qSwjmjpUwwvs9606	rogid:P8NrZDC/GnDTkXsOSI1eCUEK1nE9606	intact-crc:EC19D189F205977E|rigid:75KdQCLu6OHyQpNQ2HlHTKiQ1JU	false	sufficient binding region:103-203|his tag:c-c|tag:n-n	sufficient binding region:24-204	1	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27701	uniprotkb:P01033	intact:EBI-682379|uniprotkb:Q7Z2D4|uniprotkb:D3DQN6|intact:EBI-726186|uniprotkb:E9PC70|uniprotkb:Q7Z5N2|ensembl:ENSP00000227155	intact:EBI-712536|ensembl:ENSP00000218388|uniprotkb:Q14252|uniprotkb:Q9UCU1	psi-mi:cd82_human(display_long)|uniprotkb:Inducible membrane protein R2(gene name synonym)|uniprotkb:C33 antigen(gene name synonym)|uniprotkb:IA4(gene name synonym)|uniprotkb:Metastasis suppressor Kangai-1(gene name synonym)|uniprotkb:Suppressor of tumorigenicity 6 protein(gene name synonym)|uniprotkb:Tetraspanin-27(gene name synonym)|uniprotkb:CD82(gene name)|psi-mi:CD82(display_short)|uniprotkb:KAI1(gene name synonym)|uniprotkb:SAR2(gene name synonym)|uniprotkb:TSPAN27(gene name synonym)|uniprotkb:ST6(gene name synonym)	psi-mi:timp1_human(display_long)|uniprotkb:Tissue inhibitor of metalloproteinases 1(gene name synonym)|uniprotkb:Erythroid-potentiating activity(gene name synonym)|uniprotkb:Fibroblast collagenase inhibitor(gene name synonym)|uniprotkb:TIMP1(gene name)|psi-mi:TIMP1(display_short)|uniprotkb:CLGI(gene name synonym)|uniprotkb:TIMP(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zhang et al. (2017)	pubmed:28030805|imex:IM-22622	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9679903|imex:IM-22622-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020015.1|refseq:NP_002222.1|refseq:XP_006718286.1|ensembl:ENSG00000085117(gene)|ensembl:ENST00000227155(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P27701	go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1905049"(negative regulation of metallopeptidase activity)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015611(Tissue inhibitor of metalloprotease 1)|interpro:IPR027465|interpro:IPR030490|mint:P01033|rcsb pdb:1D2B|rcsb pdb:1LQN|rcsb pdb:1OO9|rcsb pdb:2J0T|rcsb pdb:3MA2|rcsb pdb:3V96|rcsb pdb:6MAV|rcsb pdb:6N9D|reactome:R-HSA-114608|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8957275|rcsb pdb:1UEA|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000102265(gene)|ensembl:ENST00000218388(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0007568"(aging)|go:"GO:0005125"(cytokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|refseq:NP_003245.1|dip:DIP-1107N	go:"GO:0009986"(cell surface)	-	-	figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-pancreas_cancer)|taxid:9606(Human pancreatic tissue)	-	2014/07/23	2014/10/16	rogid:8Ow5hrE81Uf1Lqyb9lRIUg2Ng5I9606	rogid:P8NrZDC/GnDTkXsOSI1eCUEK1nE9606	intact-crc:813D24AFB36ED1E9|rigid:u07e6CvcU38+YOfC2LjESH/hH/8	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P01033	uniprotkb:P27701	intact:EBI-712536|ensembl:ENSP00000218388|uniprotkb:Q14252|uniprotkb:Q9UCU1	intact:EBI-682379|uniprotkb:Q7Z2D4|uniprotkb:D3DQN6|intact:EBI-726186|uniprotkb:E9PC70|uniprotkb:Q7Z5N2|ensembl:ENSP00000227155	psi-mi:timp1_human(display_long)|uniprotkb:Tissue inhibitor of metalloproteinases 1(gene name synonym)|uniprotkb:Erythroid-potentiating activity(gene name synonym)|uniprotkb:Fibroblast collagenase inhibitor(gene name synonym)|uniprotkb:TIMP1(gene name)|psi-mi:TIMP1(display_short)|uniprotkb:CLGI(gene name synonym)|uniprotkb:TIMP(gene name synonym)	psi-mi:cd82_human(display_long)|uniprotkb:Inducible membrane protein R2(gene name synonym)|uniprotkb:C33 antigen(gene name synonym)|uniprotkb:IA4(gene name synonym)|uniprotkb:Metastasis suppressor Kangai-1(gene name synonym)|uniprotkb:Suppressor of tumorigenicity 6 protein(gene name synonym)|uniprotkb:Tetraspanin-27(gene name synonym)|uniprotkb:CD82(gene name)|psi-mi:CD82(display_short)|uniprotkb:KAI1(gene name synonym)|uniprotkb:SAR2(gene name synonym)|uniprotkb:TSPAN27(gene name synonym)|uniprotkb:ST6(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zhang et al. (2017)	pubmed:28030805|imex:IM-22622	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9679881|imex:IM-22622-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1905049"(negative regulation of metallopeptidase activity)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015611(Tissue inhibitor of metalloprotease 1)|interpro:IPR027465|interpro:IPR030490|mint:P01033|rcsb pdb:1D2B|rcsb pdb:1LQN|rcsb pdb:1OO9|rcsb pdb:2J0T|rcsb pdb:3MA2|rcsb pdb:3V96|rcsb pdb:6MAV|rcsb pdb:6N9D|reactome:R-HSA-114608|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8957275|rcsb pdb:1UEA|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000102265(gene)|ensembl:ENST00000218388(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0007568"(aging)|go:"GO:0005125"(cytokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|refseq:NP_003245.1|dip:DIP-1107N	refseq:NP_001020015.1|refseq:NP_002222.1|refseq:XP_006718286.1|ensembl:ENSG00000085117(gene)|ensembl:ENST00000227155(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P27701	go:"GO:0009986"(cell surface)	-	-	figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-breast_cancer)|taxid:9606(Homo sapiens breast cancer tissue)	-	2014/07/23	2014/10/16	rogid:P8NrZDC/GnDTkXsOSI1eCUEK1nE9606	rogid:8Ow5hrE81Uf1Lqyb9lRIUg2Ng5I9606	intact-crc:A5B6A6CED8FA7F91|rigid:u07e6CvcU38+YOfC2LjESH/hH/8	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P27701	uniprotkb:P01033	intact:EBI-682379|uniprotkb:Q7Z2D4|uniprotkb:D3DQN6|intact:EBI-726186|uniprotkb:E9PC70|uniprotkb:Q7Z5N2|ensembl:ENSP00000227155	intact:EBI-712536|ensembl:ENSP00000218388|uniprotkb:Q14252|uniprotkb:Q9UCU1	psi-mi:cd82_human(display_long)|uniprotkb:Inducible membrane protein R2(gene name synonym)|uniprotkb:C33 antigen(gene name synonym)|uniprotkb:IA4(gene name synonym)|uniprotkb:Metastasis suppressor Kangai-1(gene name synonym)|uniprotkb:Suppressor of tumorigenicity 6 protein(gene name synonym)|uniprotkb:Tetraspanin-27(gene name synonym)|uniprotkb:CD82(gene name)|psi-mi:CD82(display_short)|uniprotkb:KAI1(gene name synonym)|uniprotkb:SAR2(gene name synonym)|uniprotkb:TSPAN27(gene name synonym)|uniprotkb:ST6(gene name synonym)	psi-mi:timp1_human(display_long)|uniprotkb:Tissue inhibitor of metalloproteinases 1(gene name synonym)|uniprotkb:Erythroid-potentiating activity(gene name synonym)|uniprotkb:Fibroblast collagenase inhibitor(gene name synonym)|uniprotkb:TIMP1(gene name)|psi-mi:TIMP1(display_short)|uniprotkb:CLGI(gene name synonym)|uniprotkb:TIMP(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zhang et al. (2017)	pubmed:28030805|imex:IM-22622	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9679869|imex:IM-22622-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020015.1|refseq:NP_002222.1|refseq:XP_006718286.1|ensembl:ENSG00000085117(gene)|ensembl:ENST00000227155(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P27701	go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1905049"(negative regulation of metallopeptidase activity)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015611(Tissue inhibitor of metalloprotease 1)|interpro:IPR027465|interpro:IPR030490|mint:P01033|rcsb pdb:1D2B|rcsb pdb:1LQN|rcsb pdb:1OO9|rcsb pdb:2J0T|rcsb pdb:3MA2|rcsb pdb:3V96|rcsb pdb:6MAV|rcsb pdb:6N9D|reactome:R-HSA-114608|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8957275|rcsb pdb:1UEA|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000102265(gene)|ensembl:ENST00000218388(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0007568"(aging)|go:"GO:0005125"(cytokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|refseq:NP_003245.1|dip:DIP-1107N	go:"GO:0009986"(cell surface)	-	-	figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mammary epithelium)|taxid:9606(Human mammary epithelium)	-	2014/07/23	2014/10/16	rogid:8Ow5hrE81Uf1Lqyb9lRIUg2Ng5I9606	rogid:P8NrZDC/GnDTkXsOSI1eCUEK1nE9606	intact-crc:F55CC0B48982787F|rigid:u07e6CvcU38+YOfC2LjESH/hH/8	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P27701	uniprotkb:P01033	intact:EBI-682379|uniprotkb:Q7Z2D4|uniprotkb:D3DQN6|intact:EBI-726186|uniprotkb:E9PC70|uniprotkb:Q7Z5N2|ensembl:ENSP00000227155	intact:EBI-712536|ensembl:ENSP00000218388|uniprotkb:Q14252|uniprotkb:Q9UCU1	psi-mi:cd82_human(display_long)|uniprotkb:Inducible membrane protein R2(gene name synonym)|uniprotkb:C33 antigen(gene name synonym)|uniprotkb:IA4(gene name synonym)|uniprotkb:Metastasis suppressor Kangai-1(gene name synonym)|uniprotkb:Suppressor of tumorigenicity 6 protein(gene name synonym)|uniprotkb:Tetraspanin-27(gene name synonym)|uniprotkb:CD82(gene name)|psi-mi:CD82(display_short)|uniprotkb:KAI1(gene name synonym)|uniprotkb:SAR2(gene name synonym)|uniprotkb:TSPAN27(gene name synonym)|uniprotkb:ST6(gene name synonym)	psi-mi:timp1_human(display_long)|uniprotkb:Tissue inhibitor of metalloproteinases 1(gene name synonym)|uniprotkb:Erythroid-potentiating activity(gene name synonym)|uniprotkb:Fibroblast collagenase inhibitor(gene name synonym)|uniprotkb:TIMP1(gene name)|psi-mi:TIMP1(display_short)|uniprotkb:CLGI(gene name synonym)|uniprotkb:TIMP(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zhang et al. (2017)	pubmed:28030805|imex:IM-22622	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9679918|imex:IM-22622-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020015.1|refseq:NP_002222.1|refseq:XP_006718286.1|ensembl:ENSG00000085117(gene)|ensembl:ENST00000227155(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P27701	go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1905049"(negative regulation of metallopeptidase activity)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015611(Tissue inhibitor of metalloprotease 1)|interpro:IPR027465|interpro:IPR030490|mint:P01033|rcsb pdb:1D2B|rcsb pdb:1LQN|rcsb pdb:1OO9|rcsb pdb:2J0T|rcsb pdb:3MA2|rcsb pdb:3V96|rcsb pdb:6MAV|rcsb pdb:6N9D|reactome:R-HSA-114608|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8957275|rcsb pdb:1UEA|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000102265(gene)|ensembl:ENST00000218388(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0007568"(aging)|go:"GO:0005125"(cytokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|refseq:NP_003245.1|dip:DIP-1107N	-	-	-	figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-pancreas)|taxid:9606(Human pancreatic tissue)	-	2014/07/23	2014/10/16	rogid:8Ow5hrE81Uf1Lqyb9lRIUg2Ng5I9606	rogid:P8NrZDC/GnDTkXsOSI1eCUEK1nE9606	intact-crc:3BDFEAC3089A354B|rigid:u07e6CvcU38+YOfC2LjESH/hH/8	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)