#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P48283	uniprotkb:Q9Y6R1-1	intact:EBI-6859264	intact:EBI-6859278|ensembl:ENSP00000264485|ensembl:ENSP00000497468	psi-mi:cah4_rabit(display_long)|uniprotkb:CA4(gene name)|psi-mi:CA4(display_short)|uniprotkb:Carbonate dehydratase IV(gene name synonym)|uniprotkb:Carbonic anhydrase IV(gene name synonym)	psi-mi:q9y6r1-1(display_long)|uniprotkb:hcNBC(isoform synonym)|uniprotkb:hhNBC(isoform synonym)|uniprotkb:hNBC1(isoform synonym)|uniprotkb:pNBC(isoform synonym)|uniprotkb:pNCB1(isoform synonym)|uniprotkb:pNBC-1(isoform synonym)|uniprotkb:NBC1b(isoform synonym)|uniprotkb:SLC4A4(gene name)|psi-mi:SLC4A4(display_short)|uniprotkb:NBC(gene name synonym)|uniprotkb:NBC1(gene name synonym)|uniprotkb:NBCE1(gene name synonym)|uniprotkb:"Na(+)/HCO3(-) cotransporter"(gene name synonym)|uniprotkb:Solute carrier family 4 member 4(gene name synonym)|uniprotkb:kNBC1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Alvarez et al. (2003)	pubmed:14567693|imex:IM-20867	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6859297|imex:IM-20867-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001148(Carbonic anhydrase, eukaryotic)|interpro:IPR023561|refseq:NP_001075841.1|go:"GO:0004089"(carbonate dehydratase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031225"(anchored component of membrane)|interpro:IPR018343|interpro:IPR036398|interpro:IPR041874	intact:EBI-2801393(isoform-parent)|ensembl:ENSG00000080493(gene)|ensembl:ENST00000264485(transcript)|ensembl:ENST00000649996(transcript)	-	-	-	figure legend:3A and B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/10	2014/10/16	rogid:1Se9QE58/2M0DaIlAJMCWf7ai5A9986	rogid:LfsjZERD6wTfLGru+DB4dgqrU449606	intact-crc:3E2D663D8E096F61|rigid:4mE4gdnQ4Dq/721P+9klc0UjoOg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q64444	uniprotkb:O88343	intact:EBI-6859308|ensembl:ENSMUSP00000099483	intact:EBI-771342|uniprotkb:Q3USE4|uniprotkb:Q8BUG0|uniprotkb:Q8QZR9|uniprotkb:Q9R1C4|ensembl:ENSMUSP00000119325	psi-mi:cah4_mouse(display_long)|uniprotkb:Ca4(gene name)|psi-mi:Ca4(display_short)|uniprotkb:Car4(gene name synonym)|uniprotkb:Carbonate dehydratase IV(gene name synonym)|uniprotkb:Carbonic anhydrase IV(gene name synonym)	psi-mi:s4a4_mouse(display_long)|uniprotkb:"Na(+)/HCO3(-) cotransporter"(gene name synonym)|uniprotkb:Solute carrier family 4 member 4(gene name synonym)|uniprotkb:Slc4a4(gene name)|psi-mi:Slc4a4(display_short)|uniprotkb:Nbc1(gene name synonym)|uniprotkb:Nbce1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Alvarez et al. (2003)	pubmed:14567693|imex:IM-20867	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6859348|imex:IM-20867-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000000805(gene)|ensembl:ENSMUST00000103194(transcript)|go:"GO:0004089"(carbonate dehydratase activity)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0006885"(regulation of pH)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0016836"(hydro-lyase activity)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001148(Carbonic anhydrase, eukaryotic)|interpro:IPR018338|interpro:IPR018343|interpro:IPR023561|interpro:IPR036398|interpro:IPR041874|mint:Q64444|rcsb pdb:2ZNC|rcsb pdb:3ZNC|reactome:R-MMU-1237044|reactome:R-MMU-1247673|reactome:R-MMU-1475029|refseq:NP_031633.1	refseq:NP_001129732.1|refseq:NP_061230.2|ensembl:ENSMUSG00000060961(gene)|ensembl:ENSMUST00000148750(transcript)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006885"(regulation of pH)|go:"GO:0008510"("sodium:bicarbonate symporter activity")|go:"GO:0009986"(cell surface)|go:"GO:0015293"(symporter activity)|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR003024(Sodium bicarbonate cotransporter)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|mint:O88343|reactome:R-MMU-425381	-	-	-	figure legend:5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-kidney)|taxid:10090(Mus musculus)	-	2013/06/10	2014/10/16	rogid:vvBkP3OONLdrc1xGC8nZdWxnpGc10090	rogid:gZhNv38fjd32y3e6d63+ixWY5g810090	intact-crc:738A636D6BEB0343|rigid:9kPbEB88KD2XVRPR/d38j3bEVgA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88343	uniprotkb:Q64444	intact:EBI-771342|uniprotkb:Q3USE4|uniprotkb:Q8BUG0|uniprotkb:Q8QZR9|uniprotkb:Q9R1C4|ensembl:ENSMUSP00000119325	intact:EBI-6859308|ensembl:ENSMUSP00000099483	psi-mi:s4a4_mouse(display_long)|uniprotkb:"Na(+)/HCO3(-) cotransporter"(gene name synonym)|uniprotkb:Solute carrier family 4 member 4(gene name synonym)|uniprotkb:Slc4a4(gene name)|psi-mi:Slc4a4(display_short)|uniprotkb:Nbc1(gene name synonym)|uniprotkb:Nbce1(gene name synonym)	psi-mi:cah4_mouse(display_long)|uniprotkb:Ca4(gene name)|psi-mi:Ca4(display_short)|uniprotkb:Car4(gene name synonym)|uniprotkb:Carbonate dehydratase IV(gene name synonym)|uniprotkb:Carbonic anhydrase IV(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Alvarez et al. (2003)	pubmed:14567693|imex:IM-20867	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6859344|imex:IM-20867-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129732.1|refseq:NP_061230.2|ensembl:ENSMUSG00000060961(gene)|ensembl:ENSMUST00000148750(transcript)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006885"(regulation of pH)|go:"GO:0008510"("sodium:bicarbonate symporter activity")|go:"GO:0009986"(cell surface)|go:"GO:0015293"(symporter activity)|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR003024(Sodium bicarbonate cotransporter)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|mint:O88343|reactome:R-MMU-425381	ensembl:ENSMUSG00000000805(gene)|ensembl:ENSMUST00000103194(transcript)|go:"GO:0004089"(carbonate dehydratase activity)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0006885"(regulation of pH)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0016836"(hydro-lyase activity)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001148(Carbonic anhydrase, eukaryotic)|interpro:IPR018338|interpro:IPR018343|interpro:IPR023561|interpro:IPR036398|interpro:IPR041874|mint:Q64444|rcsb pdb:2ZNC|rcsb pdb:3ZNC|reactome:R-MMU-1237044|reactome:R-MMU-1247673|reactome:R-MMU-1475029|refseq:NP_031633.1	-	-	-	figure legend:5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-kidney)|taxid:10090(Mus musculus)	-	2013/06/10	2014/10/16	rogid:gZhNv38fjd32y3e6d63+ixWY5g810090	rogid:vvBkP3OONLdrc1xGC8nZdWxnpGc10090	intact-crc:9F00CA912BEB04F5|rigid:9kPbEB88KD2XVRPR/d38j3bEVgA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y6R1-1	uniprotkb:P48283	intact:EBI-6859278|ensembl:ENSP00000264485|ensembl:ENSP00000497468	intact:EBI-6859264	psi-mi:q9y6r1-1(display_long)|uniprotkb:hcNBC(isoform synonym)|uniprotkb:hhNBC(isoform synonym)|uniprotkb:hNBC1(isoform synonym)|uniprotkb:pNBC(isoform synonym)|uniprotkb:pNCB1(isoform synonym)|uniprotkb:pNBC-1(isoform synonym)|uniprotkb:NBC1b(isoform synonym)|uniprotkb:SLC4A4(gene name)|psi-mi:SLC4A4(display_short)|uniprotkb:NBC(gene name synonym)|uniprotkb:NBC1(gene name synonym)|uniprotkb:NBCE1(gene name synonym)|uniprotkb:"Na(+)/HCO3(-) cotransporter"(gene name synonym)|uniprotkb:Solute carrier family 4 member 4(gene name synonym)|uniprotkb:kNBC1(gene name synonym)	psi-mi:cah4_rabit(display_long)|uniprotkb:CA4(gene name)|psi-mi:CA4(display_short)|uniprotkb:Carbonate dehydratase IV(gene name synonym)|uniprotkb:Carbonic anhydrase IV(gene name synonym)	psi-mi:"MI:0096"(pull down)	Alvarez et al. (2003)	pubmed:14567693|imex:IM-20867	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6859359|imex:IM-20867-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2801393(isoform-parent)|ensembl:ENSG00000080493(gene)|ensembl:ENST00000264485(transcript)|ensembl:ENST00000649996(transcript)	interpro:IPR001148(Carbonic anhydrase, eukaryotic)|interpro:IPR023561|refseq:NP_001075841.1|go:"GO:0004089"(carbonate dehydratase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031225"(anchored component of membrane)|interpro:IPR018343|interpro:IPR036398|interpro:IPR041874	-	-	-	figure legend:6B and 7B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/10	2014/10/16	rogid:LfsjZERD6wTfLGru+DB4dgqrU449606	rogid:1Se9QE58/2M0DaIlAJMCWf7ai5A9986	intact-crc:731DB644BE4B6103|rigid:4mE4gdnQ4Dq/721P+9klc0UjoOg	false	sufficient binding region:748-779|glutathione s tranferase tag:?-?|mutation disrupting interaction:767-767	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)