#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8BG40	uniprotkb:Q9WV86	intact:EBI-7692933|ensembl:ENSMUSP00000034239|uniprotkb:Q8CD18|intact:UNK-5969950|uniprotkb:Q8R1J0|uniprotkb:Q9CWV2	intact:EBI-7692898|intact:MINT-8307998	psi-mi:ktnb1_mouse(display_long)|uniprotkb:p80 katanin(gene name synonym)|uniprotkb:Katnb1(gene name)|psi-mi:Katnb1(display_short)	psi-mi:ktna1_mouse(display_long)|uniprotkb:Katna1(gene name)|psi-mi:Katna1(display_short)|uniprotkb:Lipotransin(gene name synonym)|uniprotkb:p60 katanin(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Iwaya et al. (2012)	pubmed:22325007|mint:MINT-8307981	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7692893|mint:MINT-8307986	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031787(gene)|ensembl:ENSMUST00000034239(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0008017"(microtubule binding)|go:"GO:0008352"(katanin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0060590"(ATPase regulator activity)|go:"GO:0070840"(dynein complex binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026962|interpro:IPR028021|interpro:IPR036322|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:5OW5|rcsb pdb:6GZC|refseq:NP_083081.2|refseq:XP_006531473.1|refseq:XP_006531474.1|refseq:XP_006531475.1|mint:MINT-8307988(identity)	interpro:IPR028596|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001764"(neuron migration)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008104"(protein localization)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016853"(isomerase activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097431"(mitotic spindle pole)|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:2RPA|interpro:IPR027417|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR036181|interpro:IPR041569|rcsb pdb:6GZC|mint:MINT-8308015(identity)	-	comment:mint|function:Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth	comment:mint	comment:mint|figure legend:f2a f2b sf1a sf1b st1	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/02/07	2014/10/16	rogid:ucjcfzxQveYTuxBO9P+HOgJaD3A10090	rogid:NDsx6wb+8GW4j1BCk/kkwKUEVwc10090	intact-crc:AF03412DA685BB53|rigid:FckMFdAhfFCQgozJsXHNAMROQ2s	false	maltose binding protein tag:?-?(MINT-8307992)|binding-associated region:483-658(MINT-8307995)	glutathione s tranferase tag:?-?(MINT-8308016)|binding-associated region:1-72(MINT-8308019)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9WV86	uniprotkb:Q8BG40	intact:EBI-7692898|intact:MINT-8307998	intact:EBI-7692933|ensembl:ENSMUSP00000034239|uniprotkb:Q8CD18|intact:UNK-5969950|uniprotkb:Q8R1J0|uniprotkb:Q9CWV2	psi-mi:ktna1_mouse(display_long)|uniprotkb:Katna1(gene name)|psi-mi:Katna1(display_short)|uniprotkb:Lipotransin(gene name synonym)|uniprotkb:p60 katanin(gene name synonym)	psi-mi:ktnb1_mouse(display_long)|uniprotkb:p80 katanin(gene name synonym)|uniprotkb:Katnb1(gene name)|psi-mi:Katnb1(display_short)	psi-mi:"MI:0096"(pull down)	Iwaya et al. (2012)	pubmed:22325007|mint:MINT-8307981	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7693012|mint:MINT-8308025	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR028596|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001764"(neuron migration)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008104"(protein localization)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016853"(isomerase activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097431"(mitotic spindle pole)|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:2RPA|interpro:IPR027417|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR036181|interpro:IPR041569|rcsb pdb:6GZC|mint:MINT-8308033(identity)	ensembl:ENSMUSG00000031787(gene)|ensembl:ENSMUST00000034239(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0008017"(microtubule binding)|go:"GO:0008352"(katanin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0060590"(ATPase regulator activity)|go:"GO:0070840"(dynein complex binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026962|interpro:IPR028021|interpro:IPR036322|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:5OW5|rcsb pdb:6GZC|refseq:NP_083081.2|refseq:XP_006531473.1|refseq:XP_006531474.1|refseq:XP_006531475.1|mint:MINT-8308027(identity)	-	comment:mint	comment:mint|function:Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth	figure legend:f2c|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/02/07	2014/10/16	rogid:NDsx6wb+8GW4j1BCk/kkwKUEVwc10090	rogid:ucjcfzxQveYTuxBO9P+HOgJaD3A10090	intact-crc:8235090B6A011DE5|rigid:FckMFdAhfFCQgozJsXHNAMROQ2s	false	glutathione s tranferase tag:?-?(MINT-8308036)|binding-associated region:1-72(MINT-8308034)	maltose binding protein tag:?-?(MINT-8308030)|binding-associated region:483-658(MINT-8308028)	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0396"(predetermined participant)