#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9BXY4	uniprotkb:Q15075	intact:EBI-7424970|uniprotkb:B2RC27|uniprotkb:Q5VTV4|intact:MINT-8297608|uniprotkb:Q96K87|ensembl:ENSP00000349131	intact:EBI-298113|uniprotkb:Q14221|ensembl:ENSP00000317955	psi-mi:rspo3_human(display_long)|uniprotkb:PWTSR(gene name synonym)|uniprotkb:RSPO3(gene name)|psi-mi:RSPO3(display_short)|uniprotkb:Protein with TSP type-1 repeat(gene name synonym)|uniprotkb:Roof plate-specific spondin-3(gene name synonym)|uniprotkb:THSD2(gene name synonym)|uniprotkb:Thrombospondin type-1 domain-containing protein 2(gene name synonym)	psi-mi:eea1_human(display_long)|uniprotkb:EEA1(gene name)|psi-mi:EEA1(display_short)|uniprotkb:ZFYVE2(gene name synonym)|uniprotkb:Endosome-associated protein p162(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 2(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Glinka et al. (2011)	doi:10.1038/embor.2011.175|pubmed:21909076|imex:IM-16505|mint:MINT-8297435	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7424963|mint:MINT-8297588|imex:IM-16505-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116173.2|ensembl:ENSG00000146374(gene)|ensembl:ENST00000356698(transcript)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0008201"(heparin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR006212(Furin-like repeat)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036383|interpro:IPR042994|interpro:IPR043601|interpro:IPR044004|reactome:R-HSA-4641263|reactome:R-HSA-8939256|mint:MINT-8297612(identity)	ensembl:ENSG00000102189(gene)|ensembl:ENST00000322349(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005969"(serine-pyruvate aminotransferase complex)|go:"GO:0006897"(endocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044308"(axonal spine)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017455(Zinc finger, FYVE-related)|mint:Q15075|rcsb pdb:1HYI|rcsb pdb:1HYJ|rcsb pdb:1JOC|rcsb pdb:3MJH|reactome:R-HSA-168138|refseq:NP_003557.2|mint:MINT-8297590(identity)	go:"GO:0005769"(early endosome)	comment:mint|comment:homomint	-	figure legend:sf3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2011/12/02	2014/10/16	rogid:XM/8ScSCZAVPoJ7f0Cxwa827R0k9606	rogid:aKGquyBsTFm+hhbJiIbz1Lv88Hw9606	intact-crc:66357E1E8BF2C56D|rigid:RHjhh74E0MOd2sP4HlHpuiUlPMc	false	fusion protein:?-?(MINT-8297643)|binding-associated region:?-?(MINT-8297711)	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:B0BLW3	uniprotkb:Q9BXY4	intact:EBI-7425077|intact:MINT-8297617|uniprotkb:F6US71	intact:EBI-7424970|uniprotkb:B2RC27|uniprotkb:Q5VTV4|intact:MINT-8297608|uniprotkb:Q96K87|ensembl:ENSP00000349131	psi-mi:lgr4_xentr(display_long)|uniprotkb:lgr4(gene name)|psi-mi:lgr4(display_short)	psi-mi:rspo3_human(display_long)|uniprotkb:PWTSR(gene name synonym)|uniprotkb:RSPO3(gene name)|psi-mi:RSPO3(display_short)|uniprotkb:Protein with TSP type-1 repeat(gene name synonym)|uniprotkb:Roof plate-specific spondin-3(gene name synonym)|uniprotkb:THSD2(gene name synonym)|uniprotkb:Thrombospondin type-1 domain-containing protein 2(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Glinka et al. (2011)	doi:10.1038/embor.2011.175|pubmed:21909076|imex:IM-16505|mint:MINT-8297435	taxid:8364(xentr)|taxid:8364("Xenopus tropicalis (Western clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7425097|mint:MINT-8297652|imex:IM-16505-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119970.1|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016500"(protein-hormone receptor activity)|go:"GO:0030282"(bone mineralization)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0046849"(bone remodeling)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002131(Glycoprotein hormone receptor)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR032675|rcsb pdb:4LI1|rcsb pdb:4LI2|go:"GO:0001818"(negative regulation of cytokine production)|dip:DIP-60560N|mint:MINT-8297654(identity)	refseq:NP_116173.2|ensembl:ENSG00000146374(gene)|ensembl:ENST00000356698(transcript)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0008201"(heparin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR006212(Furin-like repeat)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036383|interpro:IPR042994|interpro:IPR043601|interpro:IPR044004|reactome:R-HSA-4641263|reactome:R-HSA-8939256|mint:MINT-8297655(identity)	go:"GO:0030139"(endocytic vesicle)	comment:mint	comment:mint|comment:homomint	figure legend:f3d|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2011/12/02	2014/10/16	rogid:YiEUogAukuaTsNPSiaALi2LQK0U8364	rogid:XM/8ScSCZAVPoJ7f0Cxwa827R0k9606	intact-crc:85D651E14D00C89F|rigid:9ybc7RlTcnEEbFcBN+1UI8HHgUw	false	yellow fluorescent protein tag:?-?(MINT-8297656)	fusion protein:?-?(MINT-8297692)	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)