#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q04912	uniprotkb:P09958	intact:EBI-2637518|uniprotkb:B5A944|uniprotkb:B5A945|uniprotkb:B5A946|uniprotkb:B5A947|ensembl:ENSP00000296474|uniprotkb:A0A087WZG2	intact:EBI-1056807|uniprotkb:Q14336|uniprotkb:Q6LBS3|uniprotkb:Q9UCZ5|ensembl:ENSP00000268171|ensembl:ENSP00000483552|ensembl:ENSP00000484952|ensembl:ENSP00000506143	psi-mi:ron_human(display_long)|uniprotkb:MST1R(gene name)|psi-mi:MST1R(display_short)|uniprotkb:PTK8(gene name synonym)|uniprotkb:RON(gene name synonym)|uniprotkb:p185-Ron(gene name synonym)|uniprotkb:Protein-tyrosine kinase 8(gene name synonym)|uniprotkb:CDw136(gene name synonym)	psi-mi:furin_human(display_long)|uniprotkb:FURIN(gene name)|psi-mi:FURIN(display_short)|uniprotkb:FUR(gene name synonym)|uniprotkb:PACE(gene name synonym)|uniprotkb:PCSK3(gene name synonym)|uniprotkb:Paired basic amino acid residue-cleaving enzyme(gene name synonym)|uniprotkb:Dibasic-processing enzyme(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Ma et al. (2010)	pubmed:21114864|imex:IM-15338	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-3506254|imex:IM-15338-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001231866.1|refseq:NP_002438.2|ensembl:ENSG00000164078(gene)|ensembl:ENST00000296474(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005011"(macrophage colony-stimulating factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR016244(Tyrosine-protein kinase, HGF/MSP receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036352|interpro:IPR039413|mint:Q04912|rcsb pdb:3PLS|rcsb pdb:4FWW|rcsb pdb:4QT8|reactome:R-HSA-8852405|dip:DIP-6029N	refseq:NP_002560.1|refseq:NP_001276752.1|refseq:NP_001276753.1|go:"GO:0097341"(zymogen inhibition)|go:"GO:1901394"(positive regulation of transforming growth factor beta1 activation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR002884(Proprotein convertase, P)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR022398|interpro:IPR023827|interpro:IPR023828|interpro:IPR032815|interpro:IPR034182|interpro:IPR036852|interpro:IPR038466|mint:P09958|rcsb pdb:4OMC|rcsb pdb:4OMD|rcsb pdb:4RYD|rcsb pdb:4Z2A|rcsb pdb:5JMO|rcsb pdb:5JXG|rcsb pdb:5JXH|rcsb pdb:5JXI|rcsb pdb:5JXJ|rcsb pdb:5MIM|rcsb pdb:6A8Y|rcsb pdb:6EQV|rcsb pdb:6EQW|rcsb pdb:6EQX|rcsb pdb:6HLB|rcsb pdb:6HLD|rcsb pdb:6HLE|rcsb pdb:6HZA|rcsb pdb:6HZB|rcsb pdb:6HZC|rcsb pdb:6HZD|rcsb pdb:6YD2|rcsb pdb:6YD3|rcsb pdb:6YD4|rcsb pdb:6YD7|reactome:R-HSA-1181150|reactome:R-HSA-1442490|reactome:R-HSA-1566948|reactome:R-HSA-1592389|go:"GO:0090472"(dibasic protein processing)|reactome:R-HSA-159782|reactome:R-HSA-167060|reactome:R-HSA-171286|reactome:R-HSA-186797|reactome:R-HSA-1912420|reactome:R-HSA-2173789|reactome:R-HSA-5210891|reactome:R-HSA-6809371|reactome:R-HSA-8963889|reactome:R-HSA-9662834|reactome:R-HSA-9679191|reactome:R-HSA-9694614|reactome:R-HSA-977225|ensembl:ENSG00000140564(gene)|ensembl:ENST00000268171(transcript)|ensembl:ENST00000610579(transcript)|ensembl:ENST00000618099(transcript)|ensembl:ENST00000680053(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002020"(protease binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0016486"(peptide hormone processing)|go:"GO:0019058"(viral life cycle)|go:"GO:0019082"(viral protein processing)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031638"(zymogen activation)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032902"(nerve growth factor production)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0032940"(secretion by cell)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0043043"(peptide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051004"(regulation of lipoprotein lipase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0070062"(extracellular exosome)|dip:DIP-29904N	psi-mi:"MI:0469"(intact)	-	-	figure legend:fig.4b|comment:pro-RON and pro-RON160 were correctly cleaved by furin in a dose-dependent manner. In contrast, pro-RONE5/6in was relatively insensitive to furin-mediated cleavage.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/28	2018/04/06	rogid:qwF0CoIEkkzk0ETJxoUnwwKDHho9606	rogid:fARxF82aRgmZAfcuuw1QgDBKjCU9606	intact-crc:87AD8B93E164059C|rigid:J3LWt7aOLbipHUi7YZ2UiBaZtlk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)