#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P17221 uniprotkb:Q93794 intact:EBI-1998155|uniprotkb:Q95ZU3|ensemblmetazoa:F35D6.1a.1 intact:EBI-323098|uniprotkb:O44083|uniprotkb:Q95ZT0|ensemblmetazoa:F55B12.3a.1 psi-mi:fem1_caeel(display_long)|uniprotkb:fem-1(gene name)|psi-mi:fem-1(display_short)|uniprotkb:isx-1(gene name synonym)|uniprotkb:Feminization of XX and XO animals protein 1(gene name synonym)|uniprotkb:F35D6.1(orf name) psi-mi:sel10_caeel(display_long)|uniprotkb:sel-10(gene name)|psi-mi:sel-10(display_short)|uniprotkb:F55B12.3(orf name)|uniprotkb:Suppressor/enhancer of lin-12 protein 10(gene name synonym)|uniprotkb:Egg laying defective protein 41(gene name synonym)|uniprotkb:egl-41(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2004) pubmed:15306688|imex:IM-17291 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-3651257|imex:IM-17291-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_500824.1|refseq:NP_500825.1|interpro:IPR020683|wormbase:F35D6.1a|wormbase:F35D6.1b|interpro:IPR002110(Ankyrin)|reactome:R-CEL-8951664|interpro:IPR036770|interpro:IPR011990(Tetratricopeptide-like helical)|ensemblmetazoa:F35D6.1a.1(transcript)|ensemblmetazoa:WBGene00001411(gene)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007548"(sex differentiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019100"(male germ-line sex determination)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036369"(transcription factor catabolic process)|go:"GO:0042006"(masculinization of hermaphroditic germ-line)|go:"GO:1905936"(regulation of germ cell proliferation) refseq:NP_001023975.1|refseq:NP_506421.1|wormbase:F55B12.3a|wormbase:F55B12.3b|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR020472|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|ensemblmetazoa:F55B12.3a.1(transcript)|ensemblmetazoa:WBGene00004767(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0010826"(negative regulation of centrosome duplication)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046660"(female sex differentiation)|go:"GO:0031647"(regulation of protein stability)|interpro:IPR036047|interpro:IPR036322 - - - figure legend:Fig 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line) - 2011/03/08 2014/10/16 rogid:iq2eqvK7y3FrsolQmLrQdqg4gu46239 rogid:g0ot7MHRd+isjIPmH2xt4HEUUvM6239 intact-crc:91258769729B0888|rigid:GZQcu/k1oskM61seS+zX/a1VcyU false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P34691 uniprotkb:Q93794 intact:EBI-445465|ensemblmetazoa:C01F6.4a.1 intact:EBI-323098|uniprotkb:O44083|uniprotkb:Q95ZT0|ensemblmetazoa:F55B12.3a.1 psi-mi:fem3_caeel(display_long)|uniprotkb:Feminization of XX and XO animals protein 3(gene name synonym)|uniprotkb:Ce-FEM-3(gene name synonym)|uniprotkb:C01F6.4(orf name)|uniprotkb:fem-3(gene name)|psi-mi:fem-3(display_short) psi-mi:sel10_caeel(display_long)|uniprotkb:sel-10(gene name)|psi-mi:sel-10(display_short)|uniprotkb:F55B12.3(orf name)|uniprotkb:Suppressor/enhancer of lin-12 protein 10(gene name synonym)|uniprotkb:Egg laying defective protein 41(gene name synonym)|uniprotkb:egl-41(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2004) pubmed:15306688|imex:IM-17291 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-3651249|imex:IM-17291-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:C01F6.4a.1(transcript)|ensemblmetazoa:WBGene00001413(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007548"(sex differentiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030238"(male sex determination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042006"(masculinization of hermaphroditic germ-line)|go:"GO:0043406"(positive regulation of MAP kinase activity)|interpro:IPR030804|refseq:NP_001255365.1|wormbase:C01F6.4a|go:"GO:0060282"(positive regulation of oocyte development)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:1904146"(positive regulation of meiotic cell cycle process involved in oocyte maturation)|go:"GO:1905936"(regulation of germ cell proliferation) refseq:NP_001023975.1|refseq:NP_506421.1|wormbase:F55B12.3a|wormbase:F55B12.3b|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR020472|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|ensemblmetazoa:F55B12.3a.1(transcript)|ensemblmetazoa:WBGene00004767(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0010826"(negative regulation of centrosome duplication)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046660"(female sex differentiation)|go:"GO:0031647"(regulation of protein stability)|interpro:IPR036047|interpro:IPR036322 - - - figure legend:Fig 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line) - 2011/03/08 2014/10/16 rogid:3WeE4VQ4oQC4FjKX7mUkJ/kWfGo6239 rogid:g0ot7MHRd+isjIPmH2xt4HEUUvM6239 intact-crc:B342DE4799D98419|rigid:5K4kk60mor4K9+V/DE7PdHu7NxI false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P34691 uniprotkb:Q93794 intact:EBI-445465|ensemblmetazoa:C01F6.4a.1 intact:EBI-323098|uniprotkb:O44083|uniprotkb:Q95ZT0|ensemblmetazoa:F55B12.3a.1 psi-mi:fem3_caeel(display_long)|uniprotkb:Feminization of XX and XO animals protein 3(gene name synonym)|uniprotkb:Ce-FEM-3(gene name synonym)|uniprotkb:C01F6.4(orf name)|uniprotkb:fem-3(gene name)|psi-mi:fem-3(display_short) psi-mi:sel10_caeel(display_long)|uniprotkb:sel-10(gene name)|psi-mi:sel-10(display_short)|uniprotkb:F55B12.3(orf name)|uniprotkb:Suppressor/enhancer of lin-12 protein 10(gene name synonym)|uniprotkb:Egg laying defective protein 41(gene name synonym)|uniprotkb:egl-41(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2004) pubmed:15306688|imex:IM-17291 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-3651212|imex:IM-17291-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:C01F6.4a.1(transcript)|ensemblmetazoa:WBGene00001413(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007548"(sex differentiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030238"(male sex determination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042006"(masculinization of hermaphroditic germ-line)|go:"GO:0043406"(positive regulation of MAP kinase activity)|interpro:IPR030804|refseq:NP_001255365.1|wormbase:C01F6.4a|go:"GO:0060282"(positive regulation of oocyte development)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:1904146"(positive regulation of meiotic cell cycle process involved in oocyte maturation)|go:"GO:1905936"(regulation of germ cell proliferation) refseq:NP_001023975.1|refseq:NP_506421.1|wormbase:F55B12.3a|wormbase:F55B12.3b|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR020472|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|ensemblmetazoa:F55B12.3a.1(transcript)|ensemblmetazoa:WBGene00004767(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0010826"(negative regulation of centrosome duplication)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046660"(female sex differentiation)|go:"GO:0031647"(regulation of protein stability)|interpro:IPR036047|interpro:IPR036322 - - - figure legend:Fig 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line) - 2011/03/08 2014/10/16 rogid:3WeE4VQ4oQC4FjKX7mUkJ/kWfGo6239 rogid:g0ot7MHRd+isjIPmH2xt4HEUUvM6239 intact-crc:728DEF0E71843AFB|rigid:5K4kk60mor4K9+V/DE7PdHu7NxI false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P49594 uniprotkb:Q93794 intact:EBI-1998402|ensemblmetazoa:T19C3.8.1|ensemblmetazoa:T19C3.8.2 intact:EBI-323098|uniprotkb:O44083|uniprotkb:Q95ZT0|ensemblmetazoa:F55B12.3a.1 psi-mi:fem2_caeel(display_long)|uniprotkb:"Ca(2+)/calmodulin-dependent protein kinase phosphatase"(gene name synonym)|uniprotkb:fem-2(gene name)|psi-mi:fem-2(display_short)|uniprotkb:Sex-determining protein fem-2(gene name synonym)|uniprotkb:Feminization of XX and XO animals protein 2(gene name synonym)|uniprotkb:T19C3.8(orf name) psi-mi:sel10_caeel(display_long)|uniprotkb:sel-10(gene name)|psi-mi:sel-10(display_short)|uniprotkb:F55B12.3(orf name)|uniprotkb:Suppressor/enhancer of lin-12 protein 10(gene name synonym)|uniprotkb:Egg laying defective protein 41(gene name synonym)|uniprotkb:egl-41(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2004) pubmed:15306688|imex:IM-17291 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-3651221|imex:IM-17291-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_497224.1|wormbase:T19C3.8|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR015655(Protein phosphatase 2C)|rcsb pdb:4JND|interpro:IPR036457|ensemblmetazoa:T19C3.8.1(transcript)|ensemblmetazoa:T19C3.8.2(transcript)|ensemblmetazoa:WBGene00001412(gene)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0030238"(male sex determination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042006"(masculinization of hermaphroditic germ-line)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045138"(nematode male tail tip morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307" refseq:NP_001023975.1|refseq:NP_506421.1|wormbase:F55B12.3a|wormbase:F55B12.3b|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR020472|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|ensemblmetazoa:F55B12.3a.1(transcript)|ensemblmetazoa:WBGene00004767(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0010826"(negative regulation of centrosome duplication)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046660"(female sex differentiation)|go:"GO:0031647"(regulation of protein stability)|interpro:IPR036047|interpro:IPR036322 - - - figure legend:Fig 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line) - 2011/03/08 2014/10/16 rogid:R70Rc3Xej/Sikn9mEg+MTaYT4eE6239 rogid:g0ot7MHRd+isjIPmH2xt4HEUUvM6239 intact-crc:7C36F17CE107C04A|rigid:QW9jDNH1hfV3ZNJ495j11fA3rc8 false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P17221 uniprotkb:Q93794 intact:EBI-1998155|uniprotkb:Q95ZU3|ensemblmetazoa:F35D6.1a.1 intact:EBI-323098|uniprotkb:O44083|uniprotkb:Q95ZT0|ensemblmetazoa:F55B12.3a.1 psi-mi:fem1_caeel(display_long)|uniprotkb:fem-1(gene name)|psi-mi:fem-1(display_short)|uniprotkb:isx-1(gene name synonym)|uniprotkb:Feminization of XX and XO animals protein 1(gene name synonym)|uniprotkb:F35D6.1(orf name) psi-mi:sel10_caeel(display_long)|uniprotkb:sel-10(gene name)|psi-mi:sel-10(display_short)|uniprotkb:F55B12.3(orf name)|uniprotkb:Suppressor/enhancer of lin-12 protein 10(gene name synonym)|uniprotkb:Egg laying defective protein 41(gene name synonym)|uniprotkb:egl-41(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2004) pubmed:15306688|imex:IM-17291 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-3651204|imex:IM-17291-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_500824.1|refseq:NP_500825.1|interpro:IPR020683|wormbase:F35D6.1a|wormbase:F35D6.1b|interpro:IPR002110(Ankyrin)|reactome:R-CEL-8951664|interpro:IPR036770|interpro:IPR011990(Tetratricopeptide-like helical)|ensemblmetazoa:F35D6.1a.1(transcript)|ensemblmetazoa:WBGene00001411(gene)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007548"(sex differentiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019100"(male germ-line sex determination)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036369"(transcription factor catabolic process)|go:"GO:0042006"(masculinization of hermaphroditic germ-line)|go:"GO:1905936"(regulation of germ cell proliferation) refseq:NP_001023975.1|refseq:NP_506421.1|wormbase:F55B12.3a|wormbase:F55B12.3b|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR020472|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|ensemblmetazoa:F55B12.3a.1(transcript)|ensemblmetazoa:WBGene00004767(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0010826"(negative regulation of centrosome duplication)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046660"(female sex differentiation)|go:"GO:0031647"(regulation of protein stability)|interpro:IPR036047|interpro:IPR036322 - - - figure legend:Fig 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line) - 2011/03/08 2014/10/16 rogid:iq2eqvK7y3FrsolQmLrQdqg4gu46239 rogid:g0ot7MHRd+isjIPmH2xt4HEUUvM6239 intact-crc:D6EC9FB17B56BD34|rigid:GZQcu/k1oskM61seS+zX/a1VcyU false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P49594 uniprotkb:Q93794 intact:EBI-1998402|ensemblmetazoa:T19C3.8.1|ensemblmetazoa:T19C3.8.2 intact:EBI-323098|uniprotkb:O44083|uniprotkb:Q95ZT0|ensemblmetazoa:F55B12.3a.1 psi-mi:fem2_caeel(display_long)|uniprotkb:"Ca(2+)/calmodulin-dependent protein kinase phosphatase"(gene name synonym)|uniprotkb:fem-2(gene name)|psi-mi:fem-2(display_short)|uniprotkb:Sex-determining protein fem-2(gene name synonym)|uniprotkb:Feminization of XX and XO animals protein 2(gene name synonym)|uniprotkb:T19C3.8(orf name) psi-mi:sel10_caeel(display_long)|uniprotkb:sel-10(gene name)|psi-mi:sel-10(display_short)|uniprotkb:F55B12.3(orf name)|uniprotkb:Suppressor/enhancer of lin-12 protein 10(gene name synonym)|uniprotkb:Egg laying defective protein 41(gene name synonym)|uniprotkb:egl-41(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2004) pubmed:15306688|imex:IM-17291 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-3651235|imex:IM-17291-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_497224.1|wormbase:T19C3.8|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR015655(Protein phosphatase 2C)|rcsb pdb:4JND|interpro:IPR036457|ensemblmetazoa:T19C3.8.1(transcript)|ensemblmetazoa:T19C3.8.2(transcript)|ensemblmetazoa:WBGene00001412(gene)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0030238"(male sex determination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042006"(masculinization of hermaphroditic germ-line)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045138"(nematode male tail tip morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307" refseq:NP_001023975.1|refseq:NP_506421.1|wormbase:F55B12.3a|wormbase:F55B12.3b|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR020472|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|ensemblmetazoa:F55B12.3a.1(transcript)|ensemblmetazoa:WBGene00004767(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0010826"(negative regulation of centrosome duplication)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046660"(female sex differentiation)|go:"GO:0031647"(regulation of protein stability)|interpro:IPR036047|interpro:IPR036322 - - - figure legend:Fig 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line) - 2011/03/08 2014/10/16 rogid:R70Rc3Xej/Sikn9mEg+MTaYT4eE6239 rogid:g0ot7MHRd+isjIPmH2xt4HEUUvM6239 intact-crc:D04D24D8D909D9BF|rigid:QW9jDNH1hfV3ZNJ495j11fA3rc8 false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)