#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P18852	uniprotkb:P18851	intact:EBI-7397|uniprotkb:D6VWQ5|ensemblfungi:YJR086W	intact:EBI-7390|uniprotkb:D6W2R8|ensemblfungi:YOR212W	psi-mi:gbg_yeast(display_long)|uniprotkb:J1866(orf name)|uniprotkb:YJR086W(locus name)|uniprotkb:STE18(gene name)|psi-mi:STE18(display_short)	psi-mi:gbb_yeast(display_long)|uniprotkb:YOR50-2(orf name)|uniprotkb:YOR212W(locus name)|uniprotkb:STE4(gene name)|psi-mi:STE4(display_short)	psi-mi:"MI:0018"(two hybrid)	Clark et al. (1993)	pubmed:8417317	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1565320	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012619.1|sgd:S000003846|dip:DIP-314N|ensemblfungi:YJR086W(gene)|ensemblfungi:YJR086W_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0071944"(cell periphery)|go:"GO:0120171"(Cdc24p-Far1p-Gbetagamma complex)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|interpro:IPR041848|rcsb pdb:1SCG	sgd:S000005738|refseq:NP_014855.3|mint:P18851|dip:DIP-954N|ensemblfungi:YOR212W(gene)|ensemblfungi:YOR212W_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005937"(mating projection)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010525"(regulation of transposition, RNA-mediated)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0043577"(chemotropism)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120171"(Cdc24p-Far1p-Gbetagamma complex)|go:"GO:1903260"(protein localization to mating projection tip)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|rcsb pdb:1SCG|reactome:R-SCE-6814122	-	-	crc64:4B0E26040AAA83E5	figure legend:Table 6	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/12/06	2014/10/16	rogid:qAQ9+amYOEzrDzpb0RzbjvEDqTI559292	rogid:nDgadSWQPcmSvQlIEjpNHPl3Hjc559292	intact-crc:595206BF2C04E791|rigid:/UxWk8B0EWGJSCx+gmePGJgBNXw	false	-	mutation disrupting interaction:278-278	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08539	uniprotkb:P18851	intact:EBI-7376|uniprotkb:D3DKU8|ensemblfungi:YHR005C	intact:EBI-7390|uniprotkb:D6W2R8|ensemblfungi:YOR212W	psi-mi:gpa1_yeast(display_long)|uniprotkb:YHR005C(locus name)|uniprotkb:GPA1(gene name)|psi-mi:GPA1(display_short)|uniprotkb:CDC70(gene name synonym)|uniprotkb:DAC1(gene name synonym)|uniprotkb:SCG1(gene name synonym)|uniprotkb:GP1-alpha(gene name synonym)	psi-mi:gbb_yeast(display_long)|uniprotkb:YOR50-2(orf name)|uniprotkb:YOR212W(locus name)|uniprotkb:STE4(gene name)|psi-mi:STE4(display_short)	psi-mi:"MI:0018"(two hybrid)	Clark et al. (1993)	pubmed:8417317	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1565326	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011868.1|sgd:S000001047|reactome:R-SCE-112043|reactome:R-SCE-202040|reactome:R-SCE-416482|dip:DIP-15N|reactome:R-SCE-399997|reactome:R-SCE-416476|reactome:R-SCE-418592|reactome:R-SCE-434316|reactome:R-SCE-9013148|ensemblfungi:YHR005C(gene)|ensemblfungi:YHR005C_mRNA(transcript)|go:"GO:0000742"(karyogamy involved in conjugation with cellular fusion)|go:"GO:0000743"(nuclear migration involved in conjugation with cellular fusion)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0000754"(adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048017"(inositol lipid-mediated signaling)|go:"GO:0071701"(regulation of MAPK export from nucleus)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR002975(Fungal G-protein, alpha subunit)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|rcsb pdb:1SCG|rcsb pdb:7AD3	sgd:S000005738|refseq:NP_014855.3|mint:P18851|dip:DIP-954N|ensemblfungi:YOR212W(gene)|ensemblfungi:YOR212W_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005937"(mating projection)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010525"(regulation of transposition, RNA-mediated)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0043577"(chemotropism)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120171"(Cdc24p-Far1p-Gbetagamma complex)|go:"GO:1903260"(protein localization to mating projection tip)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|rcsb pdb:1SCG|reactome:R-SCE-6814122	-	crc64:2E87C546E133D6E5	crc64:4B0E26040AAA83E5	figure legend:Table 6	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/12/06	2014/10/16	rogid:SxuqaRpicb7ZBsQju2vD6C8h3X4559292	rogid:nDgadSWQPcmSvQlIEjpNHPl3Hjc559292	intact-crc:A4D0F7285B785B35|rigid:qZT9XuLaPi6PXvNRlzA0mIUc71A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05609	uniprotkb:P49333	intact:EBI-1606697|ensemblplants:AT5G03730.1|ensemblplants:AT5G03730.2	intact:EBI-1606682|ensemblplants:AT1G66340.1	psi-mi:ctr1_arath(display_long)|uniprotkb:Protein CONSTITUTIVE TRIPLE RESPONSE1(gene name synonym)|uniprotkb:F17C15_150(orf name)|uniprotkb:CTR1(gene name)|psi-mi:CTR1(display_short)|uniprotkb:At5g03730(locus name)	psi-mi:etr1_arath(display_long)|uniprotkb:ETR1(gene name)|psi-mi:ETR1(display_short)|uniprotkb:T27F4.9(orf name)|uniprotkb:At1g66340(locus name)|uniprotkb:Protein ETHYLENE RESPONSE 1(gene name synonym)|uniprotkb:Protein ETR1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Clark et al. (1993)	pubmed:8417317	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1606739	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_195993.1|refseq:NP_850760.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|rcsb pdb:3P86|rcsb pdb:3PPZ|ensemblplants:AT5G03730(gene)|ensemblplants:AT5G03730.1(transcript)|ensemblplants:AT5G03730.2(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0009686"(gibberellin biosynthetic process)|go:"GO:0009723"(response to ethylene)|go:"GO:0009744"(response to sucrose)|go:"GO:0009750"(response to fructose)|go:"GO:0009873"(ethylene-activated signaling pathway)|go:"GO:0010105"(negative regulation of ethylene-activated signaling pathway)|go:"GO:0010182"(sugar mediated signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048510"(regulation of timing of transition from vegetative to reproductive phase)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000069"(regulation of post-embryonic root development)|interpro:IPR028324	rcsb pdb:4PL9|refseq:NP_176808.3|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR011006(CheY-like)|interpro:IPR003018(GAF)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR014525(Signal transduction histidine kinase, hybrid-type, ethylene sensor)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR001789(Signal transduction response regulator, receiver region)|rcsb pdb:1DCF|go:"GO:0009737"(response to abscisic acid)|go:"GO:0009739"(response to gibberellin)|go:"GO:0010087"(phloem or xylem histogenesis)|go:"GO:0010105"(negative regulation of ethylene-activated signaling pathway)|go:"GO:0010119"(regulation of stomatal movement)|go:"GO:0010162"(seed dormancy process)|go:"GO:0010182"(sugar mediated signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038199"(ethylene receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0051301"(cell division)|go:"GO:0051740"(ethylene binding)|go:"GO:0052544"(defense response by callose deposition in cell wall)|go:"GO:1900140"(regulation of seedling development)|interpro:IPR029016|ensemblplants:AT1G66340(gene)|ensemblplants:AT1G66340.1(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0004673"(protein histidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006952"(defense response)|go:"GO:0009408"(response to heat)|go:"GO:0009625"(response to insect)|go:"GO:0009651"(response to salt stress)|go:"GO:0009690"(cytokinin metabolic process)|go:"GO:0009723"(response to ethylene)|go:"GO:0009727"(detection of ethylene stimulus)|go:"GO:0009733"(response to auxin)|interpro:IPR036097|interpro:IPR036890	-	-	-	figure legend:Figure 1A	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/12/06	2014/10/16	rogid:alzKx+H+r2/qYHnthzzURxvJlic3702	rogid:HU7HG7EHvZR/6trEt2M2wmFdHRY3702	intact-crc:A457981C8F68FF2C|rigid:X89ylCUBHbsvXePqH1hwyXlmcvY	false	binding-associated region:53-568	binding-associated region:293-729	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)