#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P16104	uniprotkb:O76064	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-373337|uniprotkb:Q53H16|uniprotkb:Q5NKW5|uniprotkb:A6NN24|uniprotkb:A8MYC0|uniprotkb:B4DPG0|ensembl:ENSP00000362578	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:rnf8_human(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1565386|imex:IM-11890-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	refseq:NP_003949.1|refseq:NP_898901.1|ensembl:ENST00000373479(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|mint:O76064|rcsb pdb:2CSW|rcsb pdb:2PIE|rcsb pdb:4AYC|rcsb pdb:4ORH|rcsb pdb:4WHV|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|interpro:IPR017907|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000112130(gene)|dip:DIP-31265N	psi-mi:"MI:0469"(intact)	-	-	agonist:"Irradiation (10Gy)"|figure legend:Figure 1B and Supp Fig 1D.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/12/06	2014/10/16	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	intact-crc:1D421F2532298EA6|rigid:MJc8YBgDsZjTdPWQ61DJ+AbrULY	false	O-phospho-L-serine:140-140	myc tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q14676	uniprotkb:O76064	intact:EBI-495644|uniprotkb:A2AB04|uniprotkb:A2BF04|uniprotkb:A2RRA8|uniprotkb:A7YY86|uniprotkb:B0S8A2|uniprotkb:Q0EFC2|uniprotkb:Q2L6H7|uniprotkb:Q2TAZ4|uniprotkb:Q5ST83|uniprotkb:Q68CQ3|uniprotkb:Q86Z06|uniprotkb:Q96QC2|uniprotkb:Q5JP55|uniprotkb:Q5JP56|ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000387429|ensembl:ENSP00000396484|ensembl:ENSP00000404318|ensembl:ENSP00000409167|ensembl:ENSP00000415212|ensembl:ENSP00000416511|intact:EBI-28978228	intact:EBI-373337|uniprotkb:Q53H16|uniprotkb:Q5NKW5|uniprotkb:A6NN24|uniprotkb:A8MYC0|uniprotkb:B4DPG0|ensembl:ENSP00000362578	psi-mi:mdc1_human(display_long)|uniprotkb:Nuclear factor with BRCT domains 1(gene name synonym)|uniprotkb:MDC1(gene name)|psi-mi:MDC1(display_short)|uniprotkb:KIAA0170(gene name synonym)|uniprotkb:NFBD1(gene name synonym)	psi-mi:rnf8_human(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1565405|imex:IM-11890-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000396484|ensembl:ENSP00000416511|ensembl:ENSP00000387429|ensembl:ENSP00000404318|ensembl:ENSP00000415212|ensembl:ENSP00000409167|refseq:NP_055456.2|refseq:XP_011513303.1|refseq:XP_011513305.1|refseq:XP_005249551.1|dip:DIP-33603N|refseq:XP_016867008.1|ensembl:ENSG00000137337(gene)|ensembl:ENSG00000206481(gene)|ensembl:ENSG00000225589(gene)|ensembl:ENSG00000228575(gene)|ensembl:ENSG00000231135(gene)|ensembl:ENSG00000234012(gene)|ensembl:ENSG00000237095(gene)|ensembl:ENST00000376406(transcript)|ensembl:ENST00000383566(transcript)|ensembl:ENST00000420019(transcript)|ensembl:ENST00000420320(transcript)|ensembl:ENST00000427406(transcript)|ensembl:ENSG00000224587(gene)|ensembl:ENST00000435664(transcript)|ensembl:ENST00000440369(transcript)|ensembl:ENST00000449153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0070975"(FHA domain binding)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001357(BRCT)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036420|mint:Q14676|rcsb pdb:2ADO|rcsb pdb:2AZM|rcsb pdb:2ETX|rcsb pdb:3K05|rcsb pdb:3UEO|rcsb pdb:3UMZ|rcsb pdb:3UN0|rcsb pdb:3UNM|rcsb pdb:3UNN|rcsb pdb:3UOT|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-6796648|reactome:R-HSA-69473	refseq:NP_003949.1|refseq:NP_898901.1|ensembl:ENST00000373479(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|mint:O76064|rcsb pdb:2CSW|rcsb pdb:2PIE|rcsb pdb:4AYC|rcsb pdb:4ORH|rcsb pdb:4WHV|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|interpro:IPR017907|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000112130(gene)|dip:DIP-31265N	psi-mi:"MI:0469"(intact)	-	-	agonist:"Irradiation (10Gy)"|figure legend:Supp Fig 1C.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/12/06	2014/10/16	rogid:fkclTpFKHkxAjNuMuTmZRAigCa89606	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	intact-crc:FBBF6CFF3F86BC07|rigid:WM60t0Q5m3+wMkXQt7aGT5dnQwk	false	-	myc tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:O60934	uniprotkb:O76064	intact:EBI-494844|uniprotkb:O60672|uniprotkb:Q32NF7|uniprotkb:Q53FM6|uniprotkb:Q63HR6|uniprotkb:Q7LDM2|uniprotkb:B2R626|uniprotkb:B2RNC5|ensembl:ENSP00000265433	intact:EBI-373337|uniprotkb:Q53H16|uniprotkb:Q5NKW5|uniprotkb:A6NN24|uniprotkb:A8MYC0|uniprotkb:B4DPG0|ensembl:ENSP00000362578	psi-mi:nbn_human(display_long)|uniprotkb:Nijmegen breakage syndrome protein 1(gene name synonym)|uniprotkb:Cell cycle regulatory protein p95(gene name synonym)|uniprotkb:NBN(gene name)|psi-mi:NBN(display_short)|uniprotkb:NBS1(gene name synonym)|uniprotkb:NBS(gene name synonym)|uniprotkb:P95(gene name synonym)	psi-mi:rnf8_human(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1565419|imex:IM-11890-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002476.2|refseq:NP_001019859.1|refseq:XP_011515347.1|dip:DIP-33605N|ensembl:ENSG00000104320(gene)|ensembl:ENST00000265433(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016605"(PML body)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045190"(isotype switching)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090656"(t-circle formation)|go:"GO:0090737"(telomere maintenance via telomere trimming)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013908(DNA  repair Nbs1, C-terminal)|interpro:IPR016592(Nibrin)|interpro:IPR032429|interpro:IPR036420|interpro:IPR040227|interpro:IPR043014|mint:O60934|rcsb pdb:5WQD|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616	refseq:NP_003949.1|refseq:NP_898901.1|ensembl:ENST00000373479(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|mint:O76064|rcsb pdb:2CSW|rcsb pdb:2PIE|rcsb pdb:4AYC|rcsb pdb:4ORH|rcsb pdb:4WHV|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|interpro:IPR017907|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000112130(gene)|dip:DIP-31265N	psi-mi:"MI:0469"(intact)	-	-	agonist:"Irradiation (10Gy)"|figure legend:Supp Fig 1C.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/12/06	2014/10/16	rogid:CTx61/3iHRb2kWfb5u/CSye5A2k9606	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	intact-crc:A4441371B6D7BE7E|rigid:HzbsiEyXN5uEKYo1HeLVU0+CYaM	false	-	myc tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q12888	uniprotkb:O76064	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-373337|uniprotkb:Q53H16|uniprotkb:Q5NKW5|uniprotkb:A6NN24|uniprotkb:A8MYC0|uniprotkb:B4DPG0|ensembl:ENSP00000362578	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:rnf8_human(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1565430|imex:IM-11890-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	refseq:NP_003949.1|refseq:NP_898901.1|ensembl:ENST00000373479(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|mint:O76064|rcsb pdb:2CSW|rcsb pdb:2PIE|rcsb pdb:4AYC|rcsb pdb:4ORH|rcsb pdb:4WHV|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|interpro:IPR017907|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000112130(gene)|dip:DIP-31265N	psi-mi:"MI:0469"(intact)	-	-	agonist:"Irradiation (10Gy)"|figure legend:Supp Fig 1C.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/12/06	2014/10/16	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	intact-crc:15AB90342F1F5CEA|rigid:ndgRC/aaVXW+/SA9jjmaGuQ9lCg	false	-	myc tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P38398	uniprotkb:O76064	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	intact:EBI-373337|uniprotkb:Q53H16|uniprotkb:Q5NKW5|uniprotkb:A6NN24|uniprotkb:A8MYC0|uniprotkb:B4DPG0|ensembl:ENSP00000362578	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:rnf8_human(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1565447|imex:IM-11890-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N	refseq:NP_003949.1|refseq:NP_898901.1|ensembl:ENST00000373479(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|mint:O76064|rcsb pdb:2CSW|rcsb pdb:2PIE|rcsb pdb:4AYC|rcsb pdb:4ORH|rcsb pdb:4WHV|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|interpro:IPR017907|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000112130(gene)|dip:DIP-31265N	psi-mi:"MI:0469"(intact)	-	-	agonist:"Irradiation (10Gy)"|figure legend:Supp Fig 1C.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/12/06	2014/10/16	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	intact-crc:EB3CA1CD2519BFFA|rigid:pnNmSbZqTeAI17je6v/tN7D+3e0	false	-	myc tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q13315	uniprotkb:O76064	intact:EBI-495465|uniprotkb:O15429|uniprotkb:Q12758|uniprotkb:Q16551|uniprotkb:Q93007|uniprotkb:Q9NP02|uniprotkb:Q9UCX7|intact:EBI-1059333|uniprotkb:B2RNX5|intact:EBI-28985245|ensembl:ENSP00000278616|ensembl:ENSP00000388058|ensembl:ENSP00000501606	intact:EBI-373337|uniprotkb:Q53H16|uniprotkb:Q5NKW5|uniprotkb:A6NN24|uniprotkb:A8MYC0|uniprotkb:B4DPG0|ensembl:ENSP00000362578	psi-mi:atm_human(display_long)|uniprotkb:ATM(gene name)|psi-mi:ATM(display_short)|uniprotkb:Ataxia telangiectasia mutated(gene name synonym)	psi-mi:rnf8_human(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1565467|imex:IM-11890-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000042.3|refseq:XP_011541142.1|ensembl:ENSP00000501606|ensembl:ENSP00000278616|ensembl:ENSP00000388058|refseq:XP_005271618.2|refseq:XP_005271619.2|refseq:XP_006718906.1|refseq:XP_006718908.1|dip:DIP-182N|refseq:XP_016873278.1|refseq:XP_016873279.1|ensembl:ENSG00000149311(gene)|ensembl:ENST00000452508(transcript)|ensembl:ENST00000675843(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0003677"(DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007165"(signal transduction)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0097694"(establishment of RNA localization to telomere)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904354"(negative regulation of telomere capping)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904884"(positive regulation of telomerase catalytic core complex assembly)|go:"GO:1990391"(DNA repair complex)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR015519(Ataxia-Telangiectasia Mutated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR021668|interpro:IPR036940|interpro:IPR044107|ensembl:ENST00000278616(transcript)|mint:Q13315|rcsb pdb:5NP0|rcsb pdb:5NP1|rcsb pdb:6HKA|rcsb pdb:6K9K|rcsb pdb:6K9L|reactome:R-HSA-2559586|reactome:R-HSA-3371453|reactome:R-HSA-349425|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803207|reactome:R-HSA-6804756|reactome:R-HSA-6804760|reactome:R-HSA-69473|reactome:R-HSA-69541|reactome:R-HSA-912446|reactome:R-HSA-9664873|reactome:R-HSA-6804757	refseq:NP_003949.1|refseq:NP_898901.1|ensembl:ENST00000373479(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|mint:O76064|rcsb pdb:2CSW|rcsb pdb:2PIE|rcsb pdb:4AYC|rcsb pdb:4ORH|rcsb pdb:4WHV|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|interpro:IPR017907|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000112130(gene)|dip:DIP-31265N	psi-mi:"MI:0469"(intact)	-	-	agonist:"Irradiation (10Gy)"|figure legend:Supp Fig 1C.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/12/06	2014/10/16	rogid:d/FYo7KdBblfR/inXUZpFlWTfoo9606	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	intact-crc:53E92AD5C5789703|rigid:OIbfzSK4fJjSe12fhMnNHWqfVes	false	O-phospho-L-serine:1981-1981	myc tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:O76064	uniprotkb:Q8NEM0	intact:EBI-373337|uniprotkb:Q53H16|uniprotkb:Q5NKW5|uniprotkb:A6NN24|uniprotkb:A8MYC0|uniprotkb:B4DPG0|ensembl:ENSP00000362578	intact:EBI-1565483|uniprotkb:Q66GU1|uniprotkb:Q9H9C7|uniprotkb:A0A075B6F8|uniprotkb:B4DWW2|uniprotkb:E9PH63|uniprotkb:E9PGU5|ensembl:ENSP00000342924|ensembl:ENSP00000493874	psi-mi:rnf8_human(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:mcph1_human(display_long)|uniprotkb:MCPH1(gene name)|psi-mi:MCPH1(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1565493|imex:IM-11890-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003949.1|refseq:NP_898901.1|ensembl:ENST00000373479(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|mint:O76064|rcsb pdb:2CSW|rcsb pdb:2PIE|rcsb pdb:4AYC|rcsb pdb:4ORH|rcsb pdb:4WHV|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|interpro:IPR017907|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000112130(gene)|dip:DIP-31265N	refseq:NP_001166045.1|refseq:NP_001166046.1|refseq:NP_078872.2|refseq:NP_001308971.1|refseq:NP_001308972.1|refseq:NP_001308974.1|dip:DIP-39802N|ensembl:ENSG00000147316(gene)|ensembl:ENSG00000285262(gene)|ensembl:ENST00000344683(transcript)|ensembl:ENST00000647051(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060348"(bone development)|go:"GO:0060623"(regulation of chromosome condensation)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR001357(BRCT)|interpro:IPR022047|interpro:IPR029504|interpro:IPR036420|mint:Q8NEM0|rcsb pdb:2WT8|rcsb pdb:3KTF|rcsb pdb:3PA6|rcsb pdb:3SHT|rcsb pdb:3SHV|rcsb pdb:3SZM|rcsb pdb:3T1N|rcsb pdb:3U3Z|rcsb pdb:7C5D|reactome:R-HSA-2299718	psi-mi:"MI:0469"(intact)	-	crc64:D17961B94EC240A3	agonist:"Irradiation (10Gy)"|figure legend:Supp Fig 1C.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/12/06	2017/05/26	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	rogid:EL5tbrvv9UfYCOmG+7yweFO2zH49606	intact-crc:90614802E765EBBF|rigid:KRZ1cj3ry65ByVjnoL2KNOlMB5s	false	myc tag:?-?	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q13416	uniprotkb:O76064	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	intact:EBI-373337|uniprotkb:Q53H16|uniprotkb:Q5NKW5|uniprotkb:A6NN24|uniprotkb:A8MYC0|uniprotkb:B4DPG0|ensembl:ENSP00000362578	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:rnf8_human(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1565510|imex:IM-11890-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	refseq:NP_003949.1|refseq:NP_898901.1|ensembl:ENST00000373479(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|mint:O76064|rcsb pdb:2CSW|rcsb pdb:2PIE|rcsb pdb:4AYC|rcsb pdb:4ORH|rcsb pdb:4WHV|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|interpro:IPR017907|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000112130(gene)|dip:DIP-31265N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1D|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/12/06	2014/10/16	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	intact-crc:5AB5CCFA346CFFDC|rigid:sZ7PhHQLKQvBrAp380RM9kZTTUI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P27661	uniprotkb:O76064	intact:EBI-495621|ensembl:ENSMUSP00000051432	intact:EBI-373337|uniprotkb:Q53H16|uniprotkb:Q5NKW5|uniprotkb:A6NN24|uniprotkb:A8MYC0|uniprotkb:B4DPG0|ensembl:ENSP00000362578	psi-mi:h2ax_mouse(display_long)|uniprotkb:H2ax(gene name)|psi-mi:H2ax(display_short)|uniprotkb:H2a.x(gene name synonym)|uniprotkb:H2afx(gene name synonym)|uniprotkb:Hist5-2ax(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:rnf8_human(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1565524|imex:IM-11890-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034566.1|ensembl:ENSMUSG00000049932(gene)|ensembl:ENSMUST00000052686(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P27661|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-212300|reactome:R-MMU-2299718|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559586|reactome:R-MMU-427359|reactome:R-MMU-427413|reactome:R-MMU-5250924|reactome:R-MMU-5578749|reactome:R-MMU-5625886|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-606279|reactome:R-MMU-69473|reactome:R-MMU-73728|reactome:R-MMU-73772|reactome:R-MMU-8936459|reactome:R-MMU-9018519|reactome:R-MMU-9670095|reactome:R-MMU-5693607	refseq:NP_003949.1|refseq:NP_898901.1|ensembl:ENST00000373479(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|mint:O76064|rcsb pdb:2CSW|rcsb pdb:2PIE|rcsb pdb:4AYC|rcsb pdb:4ORH|rcsb pdb:4WHV|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|interpro:IPR017907|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000112130(gene)|dip:DIP-31265N	psi-mi:"MI:0469"(intact)	-	-	agonist:"Irradiation (10Gy)"|figure legend:Figure 1E, 1F, Supp. Fig 1D|comment:Interaction requires the expression of MDC1|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2007/12/06	2014/10/16	rogid:Z1pmQt/GCyjkaDs6Ot8O7Cc8rAM10090	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	intact-crc:F65547171E1686CA|rigid:rT3Cb8/Bi1TrOmDi92RvYp4b3wE	false	mutation decreasing interaction:140-140|O-phospho-L-serine:140-140	flag tag:?-?|necessary binding region:13-146	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q14676	uniprotkb:O76064	intact:EBI-495644|uniprotkb:A2AB04|uniprotkb:A2BF04|uniprotkb:A2RRA8|uniprotkb:A7YY86|uniprotkb:B0S8A2|uniprotkb:Q0EFC2|uniprotkb:Q2L6H7|uniprotkb:Q2TAZ4|uniprotkb:Q5ST83|uniprotkb:Q68CQ3|uniprotkb:Q86Z06|uniprotkb:Q96QC2|uniprotkb:Q5JP55|uniprotkb:Q5JP56|ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000387429|ensembl:ENSP00000396484|ensembl:ENSP00000404318|ensembl:ENSP00000409167|ensembl:ENSP00000415212|ensembl:ENSP00000416511|intact:EBI-28978228	intact:EBI-373337|uniprotkb:Q53H16|uniprotkb:Q5NKW5|uniprotkb:A6NN24|uniprotkb:A8MYC0|uniprotkb:B4DPG0|ensembl:ENSP00000362578	psi-mi:mdc1_human(display_long)|uniprotkb:Nuclear factor with BRCT domains 1(gene name synonym)|uniprotkb:MDC1(gene name)|psi-mi:MDC1(display_short)|uniprotkb:KIAA0170(gene name synonym)|uniprotkb:NFBD1(gene name synonym)	psi-mi:rnf8_human(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1565587|imex:IM-11890-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000396484|ensembl:ENSP00000416511|ensembl:ENSP00000387429|ensembl:ENSP00000404318|ensembl:ENSP00000415212|ensembl:ENSP00000409167|refseq:NP_055456.2|refseq:XP_011513303.1|refseq:XP_011513305.1|refseq:XP_005249551.1|dip:DIP-33603N|refseq:XP_016867008.1|ensembl:ENSG00000137337(gene)|ensembl:ENSG00000206481(gene)|ensembl:ENSG00000225589(gene)|ensembl:ENSG00000228575(gene)|ensembl:ENSG00000231135(gene)|ensembl:ENSG00000234012(gene)|ensembl:ENSG00000237095(gene)|ensembl:ENST00000376406(transcript)|ensembl:ENST00000383566(transcript)|ensembl:ENST00000420019(transcript)|ensembl:ENST00000420320(transcript)|ensembl:ENST00000427406(transcript)|ensembl:ENSG00000224587(gene)|ensembl:ENST00000435664(transcript)|ensembl:ENST00000440369(transcript)|ensembl:ENST00000449153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0070975"(FHA domain binding)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001357(BRCT)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036420|mint:Q14676|rcsb pdb:2ADO|rcsb pdb:2AZM|rcsb pdb:2ETX|rcsb pdb:3K05|rcsb pdb:3UEO|rcsb pdb:3UMZ|rcsb pdb:3UN0|rcsb pdb:3UNM|rcsb pdb:3UNN|rcsb pdb:3UOT|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-6796648|reactome:R-HSA-69473	refseq:NP_003949.1|refseq:NP_898901.1|ensembl:ENST00000373479(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|mint:O76064|rcsb pdb:2CSW|rcsb pdb:2PIE|rcsb pdb:4AYC|rcsb pdb:4ORH|rcsb pdb:4WHV|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|interpro:IPR017907|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000112130(gene)|dip:DIP-31265N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 3C|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/12/06	2014/10/16	rogid:fkclTpFKHkxAjNuMuTmZRAigCa89606	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	intact-crc:EF5CDE8F175CD784|rigid:WM60t0Q5m3+wMkXQt7aGT5dnQwk	false	flag tag:?-?|necessary binding region:698-768	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q14676	uniprotkb:O76064	intact:EBI-495644|uniprotkb:A2AB04|uniprotkb:A2BF04|uniprotkb:A2RRA8|uniprotkb:A7YY86|uniprotkb:B0S8A2|uniprotkb:Q0EFC2|uniprotkb:Q2L6H7|uniprotkb:Q2TAZ4|uniprotkb:Q5ST83|uniprotkb:Q68CQ3|uniprotkb:Q86Z06|uniprotkb:Q96QC2|uniprotkb:Q5JP55|uniprotkb:Q5JP56|ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000387429|ensembl:ENSP00000396484|ensembl:ENSP00000404318|ensembl:ENSP00000409167|ensembl:ENSP00000415212|ensembl:ENSP00000416511|intact:EBI-28978228	intact:EBI-373337|uniprotkb:Q53H16|uniprotkb:Q5NKW5|uniprotkb:A6NN24|uniprotkb:A8MYC0|uniprotkb:B4DPG0|ensembl:ENSP00000362578	psi-mi:mdc1_human(display_long)|uniprotkb:Nuclear factor with BRCT domains 1(gene name synonym)|uniprotkb:MDC1(gene name)|psi-mi:MDC1(display_short)|uniprotkb:KIAA0170(gene name synonym)|uniprotkb:NFBD1(gene name synonym)	psi-mi:rnf8_human(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1565598|imex:IM-11890-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000396484|ensembl:ENSP00000416511|ensembl:ENSP00000387429|ensembl:ENSP00000404318|ensembl:ENSP00000415212|ensembl:ENSP00000409167|refseq:NP_055456.2|refseq:XP_011513303.1|refseq:XP_011513305.1|refseq:XP_005249551.1|dip:DIP-33603N|refseq:XP_016867008.1|ensembl:ENSG00000137337(gene)|ensembl:ENSG00000206481(gene)|ensembl:ENSG00000225589(gene)|ensembl:ENSG00000228575(gene)|ensembl:ENSG00000231135(gene)|ensembl:ENSG00000234012(gene)|ensembl:ENSG00000237095(gene)|ensembl:ENST00000376406(transcript)|ensembl:ENST00000383566(transcript)|ensembl:ENST00000420019(transcript)|ensembl:ENST00000420320(transcript)|ensembl:ENST00000427406(transcript)|ensembl:ENSG00000224587(gene)|ensembl:ENST00000435664(transcript)|ensembl:ENST00000440369(transcript)|ensembl:ENST00000449153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0070975"(FHA domain binding)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001357(BRCT)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036420|mint:Q14676|rcsb pdb:2ADO|rcsb pdb:2AZM|rcsb pdb:2ETX|rcsb pdb:3K05|rcsb pdb:3UEO|rcsb pdb:3UMZ|rcsb pdb:3UN0|rcsb pdb:3UNM|rcsb pdb:3UNN|rcsb pdb:3UOT|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-6796648|reactome:R-HSA-69473	refseq:NP_003949.1|refseq:NP_898901.1|ensembl:ENST00000373479(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|mint:O76064|rcsb pdb:2CSW|rcsb pdb:2PIE|rcsb pdb:4AYC|rcsb pdb:4ORH|rcsb pdb:4WHV|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|interpro:IPR017907|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000112130(gene)|dip:DIP-31265N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 3E|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/12/06	2014/10/16	rogid:fkclTpFKHkxAjNuMuTmZRAigCa89606	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	intact-crc:1DCF9EB50485146F|rigid:WM60t0Q5m3+wMkXQt7aGT5dnQwk	false	flag tag:?-?|sufficient binding region:54..54-105..105(IPR000253)	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q14676	uniprotkb:O76064	intact:EBI-495644|uniprotkb:A2AB04|uniprotkb:A2BF04|uniprotkb:A2RRA8|uniprotkb:A7YY86|uniprotkb:B0S8A2|uniprotkb:Q0EFC2|uniprotkb:Q2L6H7|uniprotkb:Q2TAZ4|uniprotkb:Q5ST83|uniprotkb:Q68CQ3|uniprotkb:Q86Z06|uniprotkb:Q96QC2|uniprotkb:Q5JP55|uniprotkb:Q5JP56|ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000387429|ensembl:ENSP00000396484|ensembl:ENSP00000404318|ensembl:ENSP00000409167|ensembl:ENSP00000415212|ensembl:ENSP00000416511|intact:EBI-28978228	intact:EBI-373337|uniprotkb:Q53H16|uniprotkb:Q5NKW5|uniprotkb:A6NN24|uniprotkb:A8MYC0|uniprotkb:B4DPG0|ensembl:ENSP00000362578	psi-mi:mdc1_human(display_long)|uniprotkb:Nuclear factor with BRCT domains 1(gene name synonym)|uniprotkb:MDC1(gene name)|psi-mi:MDC1(display_short)|uniprotkb:KIAA0170(gene name synonym)|uniprotkb:NFBD1(gene name synonym)	psi-mi:rnf8_human(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1565613|imex:IM-11890-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000396484|ensembl:ENSP00000416511|ensembl:ENSP00000387429|ensembl:ENSP00000404318|ensembl:ENSP00000415212|ensembl:ENSP00000409167|refseq:NP_055456.2|refseq:XP_011513303.1|refseq:XP_011513305.1|refseq:XP_005249551.1|dip:DIP-33603N|refseq:XP_016867008.1|ensembl:ENSG00000137337(gene)|ensembl:ENSG00000206481(gene)|ensembl:ENSG00000225589(gene)|ensembl:ENSG00000228575(gene)|ensembl:ENSG00000231135(gene)|ensembl:ENSG00000234012(gene)|ensembl:ENSG00000237095(gene)|ensembl:ENST00000376406(transcript)|ensembl:ENST00000383566(transcript)|ensembl:ENST00000420019(transcript)|ensembl:ENST00000420320(transcript)|ensembl:ENST00000427406(transcript)|ensembl:ENSG00000224587(gene)|ensembl:ENST00000435664(transcript)|ensembl:ENST00000440369(transcript)|ensembl:ENST00000449153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0070975"(FHA domain binding)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001357(BRCT)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036420|mint:Q14676|rcsb pdb:2ADO|rcsb pdb:2AZM|rcsb pdb:2ETX|rcsb pdb:3K05|rcsb pdb:3UEO|rcsb pdb:3UMZ|rcsb pdb:3UN0|rcsb pdb:3UNM|rcsb pdb:3UNN|rcsb pdb:3UOT|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-6796648|reactome:R-HSA-69473	refseq:NP_003949.1|refseq:NP_898901.1|ensembl:ENST00000373479(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|mint:O76064|rcsb pdb:2CSW|rcsb pdb:2PIE|rcsb pdb:4AYC|rcsb pdb:4ORH|rcsb pdb:4WHV|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|interpro:IPR017907|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000112130(gene)|dip:DIP-31265N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 3E|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/12/06	2014/10/16	rogid:fkclTpFKHkxAjNuMuTmZRAigCa89606	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	intact-crc:E892A23343F15E06|rigid:WM60t0Q5m3+wMkXQt7aGT5dnQwk	false	flag tag:?-?|sufficient binding region:54..54-105..105(IPR000253)	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q14676	uniprotkb:O76064	intact:EBI-495644|uniprotkb:A2AB04|uniprotkb:A2BF04|uniprotkb:A2RRA8|uniprotkb:A7YY86|uniprotkb:B0S8A2|uniprotkb:Q0EFC2|uniprotkb:Q2L6H7|uniprotkb:Q2TAZ4|uniprotkb:Q5ST83|uniprotkb:Q68CQ3|uniprotkb:Q86Z06|uniprotkb:Q96QC2|uniprotkb:Q5JP55|uniprotkb:Q5JP56|ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000387429|ensembl:ENSP00000396484|ensembl:ENSP00000404318|ensembl:ENSP00000409167|ensembl:ENSP00000415212|ensembl:ENSP00000416511|intact:EBI-28978228	intact:EBI-373337|uniprotkb:Q53H16|uniprotkb:Q5NKW5|uniprotkb:A6NN24|uniprotkb:A8MYC0|uniprotkb:B4DPG0|ensembl:ENSP00000362578	psi-mi:mdc1_human(display_long)|uniprotkb:Nuclear factor with BRCT domains 1(gene name synonym)|uniprotkb:MDC1(gene name)|psi-mi:MDC1(display_short)|uniprotkb:KIAA0170(gene name synonym)|uniprotkb:NFBD1(gene name synonym)	psi-mi:rnf8_human(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1565627|imex:IM-11890-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000396484|ensembl:ENSP00000416511|ensembl:ENSP00000387429|ensembl:ENSP00000404318|ensembl:ENSP00000415212|ensembl:ENSP00000409167|refseq:NP_055456.2|refseq:XP_011513303.1|refseq:XP_011513305.1|refseq:XP_005249551.1|dip:DIP-33603N|refseq:XP_016867008.1|ensembl:ENSG00000137337(gene)|ensembl:ENSG00000206481(gene)|ensembl:ENSG00000225589(gene)|ensembl:ENSG00000228575(gene)|ensembl:ENSG00000231135(gene)|ensembl:ENSG00000234012(gene)|ensembl:ENSG00000237095(gene)|ensembl:ENST00000376406(transcript)|ensembl:ENST00000383566(transcript)|ensembl:ENST00000420019(transcript)|ensembl:ENST00000420320(transcript)|ensembl:ENST00000427406(transcript)|ensembl:ENSG00000224587(gene)|ensembl:ENST00000435664(transcript)|ensembl:ENST00000440369(transcript)|ensembl:ENST00000449153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0070975"(FHA domain binding)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001357(BRCT)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036420|mint:Q14676|rcsb pdb:2ADO|rcsb pdb:2AZM|rcsb pdb:2ETX|rcsb pdb:3K05|rcsb pdb:3UEO|rcsb pdb:3UMZ|rcsb pdb:3UN0|rcsb pdb:3UNM|rcsb pdb:3UNN|rcsb pdb:3UOT|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-6796648|reactome:R-HSA-69473	refseq:NP_003949.1|refseq:NP_898901.1|ensembl:ENST00000373479(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|mint:O76064|rcsb pdb:2CSW|rcsb pdb:2PIE|rcsb pdb:4AYC|rcsb pdb:4ORH|rcsb pdb:4WHV|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|interpro:IPR017907|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000112130(gene)|dip:DIP-31265N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 3E|comment:An increased amount of MDC1 bound to RNF8 after irradiation, and this MDC1 was abolished with prior phosphatase treatment|agonist:"Irradiation (10Gy)"|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/12/06	2014/10/16	rogid:fkclTpFKHkxAjNuMuTmZRAigCa89606	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	intact-crc:80DC2813F279B8F4|rigid:WM60t0Q5m3+wMkXQt7aGT5dnQwk	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-1565788	uniprotkb:O76064	-	intact:EBI-373337|uniprotkb:Q53H16|uniprotkb:Q5NKW5|uniprotkb:A6NN24|uniprotkb:A8MYC0|uniprotkb:B4DPG0|ensembl:ENSP00000362578	psi-mi:rnf8_bind_peptide(display_short)|psi-mi:EBI-1565788(display_long)	psi-mi:rnf8_human(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1565791|imex:IM-11890-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003949.1|refseq:NP_898901.1|ensembl:ENST00000373479(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|mint:O76064|rcsb pdb:2CSW|rcsb pdb:2PIE|rcsb pdb:4AYC|rcsb pdb:4ORH|rcsb pdb:4WHV|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|interpro:IPR017907|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000112130(gene)|dip:DIP-31265N	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	kinetics:Arg61Gln mutant Kd=5.65E-4M|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/12/06	2014/10/16	rogid:5jAz4NAXmPcikh3za1BzBPvE3MM-1	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	intact-crc:98F7BC33526D1048|rigid:7fLXlpPVqEBGCm7I54L3ORx9K9k	false	O-phospho-L-threonine:4-4	sufficient binding region:13-146(IPR000253)|mutation decreasing interaction:61-61	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14676	uniprotkb:O76064	intact:EBI-495644|uniprotkb:A2AB04|uniprotkb:A2BF04|uniprotkb:A2RRA8|uniprotkb:A7YY86|uniprotkb:B0S8A2|uniprotkb:Q0EFC2|uniprotkb:Q2L6H7|uniprotkb:Q2TAZ4|uniprotkb:Q5ST83|uniprotkb:Q68CQ3|uniprotkb:Q86Z06|uniprotkb:Q96QC2|uniprotkb:Q5JP55|uniprotkb:Q5JP56|ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000387429|ensembl:ENSP00000396484|ensembl:ENSP00000404318|ensembl:ENSP00000409167|ensembl:ENSP00000415212|ensembl:ENSP00000416511|intact:EBI-28978228	intact:EBI-373337|uniprotkb:Q53H16|uniprotkb:Q5NKW5|uniprotkb:A6NN24|uniprotkb:A8MYC0|uniprotkb:B4DPG0|ensembl:ENSP00000362578	psi-mi:mdc1_human(display_long)|uniprotkb:Nuclear factor with BRCT domains 1(gene name synonym)|uniprotkb:MDC1(gene name)|psi-mi:MDC1(display_short)|uniprotkb:KIAA0170(gene name synonym)|uniprotkb:NFBD1(gene name synonym)	psi-mi:rnf8_human(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1565810|imex:IM-11890-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000396484|ensembl:ENSP00000416511|ensembl:ENSP00000387429|ensembl:ENSP00000404318|ensembl:ENSP00000415212|ensembl:ENSP00000409167|refseq:NP_055456.2|refseq:XP_011513303.1|refseq:XP_011513305.1|refseq:XP_005249551.1|dip:DIP-33603N|refseq:XP_016867008.1|ensembl:ENSG00000137337(gene)|ensembl:ENSG00000206481(gene)|ensembl:ENSG00000225589(gene)|ensembl:ENSG00000228575(gene)|ensembl:ENSG00000231135(gene)|ensembl:ENSG00000234012(gene)|ensembl:ENSG00000237095(gene)|ensembl:ENST00000376406(transcript)|ensembl:ENST00000383566(transcript)|ensembl:ENST00000420019(transcript)|ensembl:ENST00000420320(transcript)|ensembl:ENST00000427406(transcript)|ensembl:ENSG00000224587(gene)|ensembl:ENST00000435664(transcript)|ensembl:ENST00000440369(transcript)|ensembl:ENST00000449153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0070975"(FHA domain binding)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001357(BRCT)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036420|mint:Q14676|rcsb pdb:2ADO|rcsb pdb:2AZM|rcsb pdb:2ETX|rcsb pdb:3K05|rcsb pdb:3UEO|rcsb pdb:3UMZ|rcsb pdb:3UN0|rcsb pdb:3UNM|rcsb pdb:3UNN|rcsb pdb:3UOT|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-6796648|reactome:R-HSA-69473	refseq:NP_003949.1|refseq:NP_898901.1|ensembl:ENST00000373479(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|mint:O76064|rcsb pdb:2CSW|rcsb pdb:2PIE|rcsb pdb:4AYC|rcsb pdb:4ORH|rcsb pdb:4WHV|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|interpro:IPR017907|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000112130(gene)|dip:DIP-31265N	psi-mi:"MI:0469"(intact)	-	-	kinetics:Peptide 695-702 Kd=3.3E-6M|figure legend:Supp. Fig. S2|kinetics:Peptide 715-722 Kd=3.1E-6M|kinetics:Peptide 748-758 Kd=3.7E-6M|kinetics:Peptide 760-769 Kd=11.7E-5M|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/12/06	2014/10/16	rogid:fkclTpFKHkxAjNuMuTmZRAigCa89606	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	intact-crc:7513FB6202D6373B|rigid:WM60t0Q5m3+wMkXQt7aGT5dnQwk	false	sufficient binding region:748-758|sufficient binding region:760-769|mutation:702-702|mutation:722-722|O-phospho-L-threonine:699-699|O-phospho-L-threonine:719-719|O-phospho-L-threonine:751-751|O-phospho-L-threonine:765-765|sufficient binding region:695-702|sufficient binding region:715-722	sufficient binding region:13-146(IPR000253)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16104	uniprotkb:Q14676	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-495644|uniprotkb:A2AB04|uniprotkb:A2BF04|uniprotkb:A2RRA8|uniprotkb:A7YY86|uniprotkb:B0S8A2|uniprotkb:Q0EFC2|uniprotkb:Q2L6H7|uniprotkb:Q2TAZ4|uniprotkb:Q5ST83|uniprotkb:Q68CQ3|uniprotkb:Q86Z06|uniprotkb:Q96QC2|uniprotkb:Q5JP55|uniprotkb:Q5JP56|ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000387429|ensembl:ENSP00000396484|ensembl:ENSP00000404318|ensembl:ENSP00000409167|ensembl:ENSP00000415212|ensembl:ENSP00000416511|intact:EBI-28978228	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:mdc1_human(display_long)|uniprotkb:Nuclear factor with BRCT domains 1(gene name synonym)|uniprotkb:MDC1(gene name)|psi-mi:MDC1(display_short)|uniprotkb:KIAA0170(gene name synonym)|uniprotkb:NFBD1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1566253|imex:IM-11890-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000396484|ensembl:ENSP00000416511|ensembl:ENSP00000387429|ensembl:ENSP00000404318|ensembl:ENSP00000415212|ensembl:ENSP00000409167|refseq:NP_055456.2|refseq:XP_011513303.1|refseq:XP_011513305.1|refseq:XP_005249551.1|dip:DIP-33603N|refseq:XP_016867008.1|ensembl:ENSG00000137337(gene)|ensembl:ENSG00000206481(gene)|ensembl:ENSG00000225589(gene)|ensembl:ENSG00000228575(gene)|ensembl:ENSG00000231135(gene)|ensembl:ENSG00000234012(gene)|ensembl:ENSG00000237095(gene)|ensembl:ENST00000376406(transcript)|ensembl:ENST00000383566(transcript)|ensembl:ENST00000420019(transcript)|ensembl:ENST00000420320(transcript)|ensembl:ENST00000427406(transcript)|ensembl:ENSG00000224587(gene)|ensembl:ENST00000435664(transcript)|ensembl:ENST00000440369(transcript)|ensembl:ENST00000449153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0070975"(FHA domain binding)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001357(BRCT)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036420|mint:Q14676|rcsb pdb:2ADO|rcsb pdb:2AZM|rcsb pdb:2ETX|rcsb pdb:3K05|rcsb pdb:3UEO|rcsb pdb:3UMZ|rcsb pdb:3UN0|rcsb pdb:3UNM|rcsb pdb:3UNN|rcsb pdb:3UOT|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-6796648|reactome:R-HSA-69473	psi-mi:"MI:0469"(intact)	-	-	agonist:"Irradiation (10Gy)"|figure legend:Supp Fig 4.|comment:Proteins do not require the presence of RNF8 to colocalise|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/12/06	2014/10/16	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:fkclTpFKHkxAjNuMuTmZRAigCa89606	intact-crc:6E4887EA3B34E21B|rigid:QIOfdSTgG/XSdkpMhqRCB9GwnuM	false	O-phospho-L-serine:140-140	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P16104	uniprotkb:O76064	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-373337|uniprotkb:Q53H16|uniprotkb:Q5NKW5|uniprotkb:A6NN24|uniprotkb:A8MYC0|uniprotkb:B4DPG0|ensembl:ENSP00000362578	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:rnf8_human(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1566279|imex:IM-11890-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	refseq:NP_003949.1|refseq:NP_898901.1|ensembl:ENST00000373479(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|mint:O76064|rcsb pdb:2CSW|rcsb pdb:2PIE|rcsb pdb:4AYC|rcsb pdb:4ORH|rcsb pdb:4WHV|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|interpro:IPR017907|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000112130(gene)|dip:DIP-31265N	psi-mi:"MI:0469"(intact)	-	-	agonist:"Irradiation (10Gy)"|figure legend:Supp Fig 4.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/12/06	2014/10/16	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	intact-crc:C041CEC860DC7EEA|rigid:MJc8YBgDsZjTdPWQ61DJ+AbrULY	false	O-phospho-L-serine:140-140	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P16104	uniprotkb:O60934	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-494844|uniprotkb:O60672|uniprotkb:Q32NF7|uniprotkb:Q53FM6|uniprotkb:Q63HR6|uniprotkb:Q7LDM2|uniprotkb:B2R626|uniprotkb:B2RNC5|ensembl:ENSP00000265433	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:nbn_human(display_long)|uniprotkb:Nijmegen breakage syndrome protein 1(gene name synonym)|uniprotkb:Cell cycle regulatory protein p95(gene name synonym)|uniprotkb:NBN(gene name)|psi-mi:NBN(display_short)|uniprotkb:NBS1(gene name synonym)|uniprotkb:NBS(gene name synonym)|uniprotkb:P95(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1566286|imex:IM-11890-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	refseq:NP_002476.2|refseq:NP_001019859.1|refseq:XP_011515347.1|dip:DIP-33605N|ensembl:ENSG00000104320(gene)|ensembl:ENST00000265433(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016605"(PML body)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045190"(isotype switching)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090656"(t-circle formation)|go:"GO:0090737"(telomere maintenance via telomere trimming)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013908(DNA  repair Nbs1, C-terminal)|interpro:IPR016592(Nibrin)|interpro:IPR032429|interpro:IPR036420|interpro:IPR040227|interpro:IPR043014|mint:O60934|rcsb pdb:5WQD|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616	psi-mi:"MI:0469"(intact)	-	-	agonist:"Irradiation (10Gy)"|figure legend:Supp Fig 4.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/12/06	2014/10/16	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:CTx61/3iHRb2kWfb5u/CSye5A2k9606	intact-crc:69F1E58FE4CF2A72|rigid:PLyhhN4i2SHPyrMkABCQ8sm3WOE	false	O-phospho-L-serine:140-140	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P16104	uniprotkb:P38398	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1566293|imex:IM-11890-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N	psi-mi:"MI:0469"(intact)	-	-	agonist:"Irradiation (10Gy)"|figure legend:Supp Fig 4.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/12/06	2014/10/16	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	intact-crc:7D1E32518438C600|rigid:e+0yiY7Go++g6gi0AJL/6RLLvyU	false	O-phospho-L-serine:140-140	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P16104	uniprotkb:Q12888	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1566312|imex:IM-11890-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	psi-mi:"MI:0469"(intact)	-	-	agonist:"Irradiation (10Gy)"|figure legend:Supp Fig 4.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/12/06	2014/10/16	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	intact-crc:18F0427D66A53C01|rigid:ORKOi6tYpZ/696/lPlGlo0NDLiw	false	O-phospho-L-serine:140-140	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q12888	uniprotkb:O76064	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-373337|uniprotkb:Q53H16|uniprotkb:Q5NKW5|uniprotkb:A6NN24|uniprotkb:A8MYC0|uniprotkb:B4DPG0|ensembl:ENSP00000362578	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:rnf8_human(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1566319|imex:IM-11890-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	refseq:NP_003949.1|refseq:NP_898901.1|ensembl:ENST00000373479(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|mint:O76064|rcsb pdb:2CSW|rcsb pdb:2PIE|rcsb pdb:4AYC|rcsb pdb:4ORH|rcsb pdb:4WHV|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|interpro:IPR017907|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000112130(gene)|dip:DIP-31265N	psi-mi:"MI:0469"(intact)	-	-	agonist:"Irradiation (10Gy)"|figure legend:Supp Fig 4.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/12/06	2014/10/16	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	intact-crc:686B0E3604A5406B|rigid:ndgRC/aaVXW+/SA9jjmaGuQ9lCg	false	-	flag tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:O76064	uniprotkb:P38398	intact:EBI-373337|uniprotkb:Q53H16|uniprotkb:Q5NKW5|uniprotkb:A6NN24|uniprotkb:A8MYC0|uniprotkb:B4DPG0|ensembl:ENSP00000362578	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	psi-mi:rnf8_human(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1566327|imex:IM-11890-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003949.1|refseq:NP_898901.1|ensembl:ENST00000373479(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|mint:O76064|rcsb pdb:2CSW|rcsb pdb:2PIE|rcsb pdb:4AYC|rcsb pdb:4ORH|rcsb pdb:4WHV|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|interpro:IPR017907|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000112130(gene)|dip:DIP-31265N	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N	psi-mi:"MI:0469"(intact)	-	-	agonist:"Irradiation (10Gy)"|figure legend:Supp Fig 4.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/12/06	2014/10/16	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	intact-crc:0D857E1AE638BA6A|rigid:pnNmSbZqTeAI17je6v/tN7D+3e0	false	flag tag:?-?	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
intact:EBI-1565788	uniprotkb:O76064	-	intact:EBI-373337|uniprotkb:Q53H16|uniprotkb:Q5NKW5|uniprotkb:A6NN24|uniprotkb:A8MYC0|uniprotkb:B4DPG0|ensembl:ENSP00000362578	psi-mi:rnf8_bind_peptide(display_short)|psi-mi:EBI-1565788(display_long)	psi-mi:rnf8_human(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Huen et al. (2007)	imex:IM-11890|pubmed:18001825	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1566341|wwpdb:2PIE|imex:IM-11890-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003949.1|refseq:NP_898901.1|ensembl:ENST00000373479(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0033523"(histone H2B ubiquitination)|mint:O76064|rcsb pdb:2CSW|rcsb pdb:2PIE|rcsb pdb:4AYC|rcsb pdb:4ORH|rcsb pdb:4WHV|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|interpro:IPR017907|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043486"(histone exchange)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017335(E3 ubiquitin ligase, RNF8)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000112130(gene)|dip:DIP-31265N	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Supp. Table. S1|3d-resolution:1.35A|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/12/06	2014/10/16	rogid:5jAz4NAXmPcikh3za1BzBPvE3MM-1	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	intact-crc:0B9FDF8FD197A8EF|rigid:7fLXlpPVqEBGCm7I54L3ORx9K9k	false	O-phospho-L-threonine:4-4	sufficient binding region:13-146(IPR000253)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)