#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:G3I8R9 uniprotkb:O55242 intact:EBI-988311|intact:EBI-1557723 intact:EBI-1557700|uniprotkb:Q9JKU9|ensembl:ENSMUSP00000056027 psi-mi:bip_crigr(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:I79_019946(orf name) psi-mi:sgmr1_mouse(display_long)|uniprotkb:Sigma 1-type opioid receptor(gene name synonym)|uniprotkb:Sigmar1(gene name)|psi-mi:Sigmar1(display_short)|uniprotkb:Oprs1(gene name synonym) psi-mi:"MI:0858"(immunodepleted coimmunoprecipitation) Hayashi et al. (2007) imex:IM-12021|pubmed:17981125 taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1557718|imex:IM-12021-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|rcsb pdb:5O4P|rcsb pdb:6EOB|rcsb pdb:6EOC|rcsb pdb:6EOE|rcsb pdb:6EOF|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|refseq:NP_001233668.1|interpro:IPR029047|interpro:IPR029048|rcsb pdb:7A4V|rcsb pdb:7A4U|rcsb pdb:6ZYH|interpro:IPR042050|rcsb pdb:6H9U|rcsb pdb:6HA7|rcsb pdb:6HAB|interpro:IPR043129 refseq:NP_035144.1|refseq:NP_001273480.1|refseq:NP_001273467.1|refseq:NP_001273468.1|refseq:NP_001273469.1|refseq:NP_001273470.1|refseq:XP_017175516.1|ensembl:ENSMUSG00000036078(gene)|ensembl:ENSMUST00000059354(transcript)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006869"(lipid transport)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like) psi-mi:"MI:0469"(intact) - - figure legend:Fig 2A, S2E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line) - 2007/11/22 2014/10/16 rogid:JdZKgGCixM5M26SXAYdJMRbHSEE10029 rogid:KEY6+88EzI03FH6CSiBPcKYF3Ps10090 intact-crc:BDA908EC4856A313|rigid:Aq8sj4ZEA1IA9T1aWQ1vtslHNs0 false 35s radiolabel:?-? tag:c-c - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:A0A3L7I3A5 uniprotkb:G3I8R9 intact:EBI-1557743|ensembl:ENSCGRP00001028028|ensembl:ENSCGRP00015005381 intact:EBI-988311|intact:EBI-1557723 psi-mi:a0a3l7i3a5_crigr(display_long)|uniprotkb:Sigma non-opioid intracellular receptor 1(gene name synonym)|uniprotkb:CgPICR_003176(orf name) psi-mi:bip_crigr(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:I79_019946(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Hayashi et al. (2007) imex:IM-12021|pubmed:17981125 taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1557737|imex:IM-12021-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_007623283.1|ensembl:ENSCGRG00001024871(gene)|ensembl:ENSCGRG00015004232(gene)|ensembl:ENSCGRT00001032276(transcript)|ensembl:ENSCGRT00015006650(transcript)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like) go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|rcsb pdb:5O4P|rcsb pdb:6EOB|rcsb pdb:6EOC|rcsb pdb:6EOE|rcsb pdb:6EOF|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|refseq:NP_001233668.1|interpro:IPR029047|interpro:IPR029048|rcsb pdb:7A4V|rcsb pdb:7A4U|rcsb pdb:6ZYH|interpro:IPR042050|rcsb pdb:6H9U|rcsb pdb:6HA7|rcsb pdb:6HAB|interpro:IPR043129 psi-mi:"MI:0469"(intact) - - figure legend:Fig 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line) - 2007/11/22 2014/10/16 rogid:MW9cTeqVhD4fqlQeS6iYSsVrLHw10029 rogid:JdZKgGCixM5M26SXAYdJMRbHSEE10029 intact-crc:26F23B74CAF34435|rigid:WFrSp8zOdzd/CSC/JWIjs77H354 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G3I8R9 uniprotkb:A0A3L7I3A5 intact:EBI-988311|intact:EBI-1557723 intact:EBI-1557743|ensembl:ENSCGRP00001028028|ensembl:ENSCGRP00015005381 psi-mi:bip_crigr(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:I79_019946(orf name) psi-mi:a0a3l7i3a5_crigr(display_long)|uniprotkb:Sigma non-opioid intracellular receptor 1(gene name synonym)|uniprotkb:CgPICR_003176(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Hayashi et al. (2007) imex:IM-12021|pubmed:17981125 taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1557763|imex:IM-12021-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|rcsb pdb:5O4P|rcsb pdb:6EOB|rcsb pdb:6EOC|rcsb pdb:6EOE|rcsb pdb:6EOF|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|refseq:NP_001233668.1|interpro:IPR029047|interpro:IPR029048|rcsb pdb:7A4V|rcsb pdb:7A4U|rcsb pdb:6ZYH|interpro:IPR042050|rcsb pdb:6H9U|rcsb pdb:6HA7|rcsb pdb:6HAB|interpro:IPR043129 refseq:XP_007623283.1|ensembl:ENSCGRG00001024871(gene)|ensembl:ENSCGRG00015004232(gene)|ensembl:ENSCGRT00001032276(transcript)|ensembl:ENSCGRT00015006650(transcript)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like) psi-mi:"MI:0469"(intact) - - figure legend:Fig 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line) - 2007/11/22 2014/10/16 rogid:JdZKgGCixM5M26SXAYdJMRbHSEE10029 rogid:MW9cTeqVhD4fqlQeS6iYSsVrLHw10029 intact-crc:664751C9EC00CD47|rigid:WFrSp8zOdzd/CSC/JWIjs77H354 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A0A3L7I3A5 uniprotkb:A0A3L7IKR8 intact:EBI-1557743|ensembl:ENSCGRP00001028028|ensembl:ENSCGRP00015005381 intact:EBI-1557913 psi-mi:a0a3l7i3a5_crigr(display_long)|uniprotkb:Sigma non-opioid intracellular receptor 1(gene name synonym)|uniprotkb:CgPICR_003176(orf name) psi-mi:a0a3l7ikr8_crigr(display_long)|uniprotkb:CgPICR_020497(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Hayashi et al. (2007) imex:IM-12021|pubmed:17981125 taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1557901|imex:IM-12021-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_007623283.1|ensembl:ENSCGRG00001024871(gene)|ensembl:ENSCGRG00015004232(gene)|ensembl:ENSCGRT00001032276(transcript)|ensembl:ENSCGRT00015006650(transcript)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like) interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding) psi-mi:"MI:0469"(intact) - - figure legend:Fig 6A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line) - 2007/11/22 2014/10/16 rogid:MW9cTeqVhD4fqlQeS6iYSsVrLHw10029 rogid:4Uxb5gxZ6r4nvVabYkb4qw8WIYg10029 intact-crc:FD22312C3986B22A|rigid:uxUT4kUgnwnvKSgtTk2y2itJU9g false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O55242 uniprotkb:G3I8R9 intact:EBI-1557700|uniprotkb:Q9JKU9|ensembl:ENSMUSP00000056027 intact:EBI-988311|intact:EBI-1557723 psi-mi:sgmr1_mouse(display_long)|uniprotkb:Sigma 1-type opioid receptor(gene name synonym)|uniprotkb:Sigmar1(gene name)|psi-mi:Sigmar1(display_short)|uniprotkb:Oprs1(gene name synonym) psi-mi:bip_crigr(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:I79_019946(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Hayashi et al. (2007) imex:IM-12021|pubmed:17981125 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1557754|imex:IM-12021-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035144.1|refseq:NP_001273480.1|refseq:NP_001273467.1|refseq:NP_001273468.1|refseq:NP_001273469.1|refseq:NP_001273470.1|refseq:XP_017175516.1|ensembl:ENSMUSG00000036078(gene)|ensembl:ENSMUST00000059354(transcript)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006869"(lipid transport)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like) go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|rcsb pdb:5O4P|rcsb pdb:6EOB|rcsb pdb:6EOC|rcsb pdb:6EOE|rcsb pdb:6EOF|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|refseq:NP_001233668.1|interpro:IPR029047|interpro:IPR029048|rcsb pdb:7A4V|rcsb pdb:7A4U|rcsb pdb:6ZYH|interpro:IPR042050|rcsb pdb:6H9U|rcsb pdb:6HA7|rcsb pdb:6HAB|interpro:IPR043129 psi-mi:"MI:0469"(intact) - - antagonist:Mg2+/ATP|antagonist:Glucose deprivation|antagonist:Calcium chelator BAPTA|agonist:Ca2+, Mn2+|antagonist:Pentazocine|antagonist:SKF-10047|antagonist:"PRE-084; 2-(4-morpholino)ethyl 1-phenylcyclohexane-1-carboxylate hydrochloride"|antagonist:Fluoxetine|antagonist:"Cocaine (weak)"|agonist:Methamphetamine|antagonist:Pregnenolone sulphate|antagonist:Dehydroepiandrosterone sulphate|agonist:"NE-100; N ,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]-ethylamine monohydrochloride"|figure legend:Figs. 2B, 2D, 2G, 2H, 3A, 3B, 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line) - 2007/11/22 2014/10/16 rogid:KEY6+88EzI03FH6CSiBPcKYF3Ps10090 rogid:JdZKgGCixM5M26SXAYdJMRbHSEE10029 intact-crc:86114EA732B9FC2D|rigid:Aq8sj4ZEA1IA9T1aWQ1vtslHNs0 false tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A0A3L7I3A5 uniprotkb:A0A3L7IKR8 intact:EBI-1557743|ensembl:ENSCGRP00001028028|ensembl:ENSCGRP00015005381 intact:EBI-1557913 psi-mi:a0a3l7i3a5_crigr(display_long)|uniprotkb:Sigma non-opioid intracellular receptor 1(gene name synonym)|uniprotkb:CgPICR_003176(orf name) psi-mi:a0a3l7ikr8_crigr(display_long)|uniprotkb:CgPICR_020497(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Hayashi et al. (2007) imex:IM-12021|pubmed:17981125 taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1557966|imex:IM-12021-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_007623283.1|ensembl:ENSCGRG00001024871(gene)|ensembl:ENSCGRG00015004232(gene)|ensembl:ENSCGRT00001032276(transcript)|ensembl:ENSCGRT00015006650(transcript)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like) interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding) psi-mi:"MI:0469"(intact) - - figure legend:Fig 6A, 6D|agonist:"Thapsigargin (inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases)"|agonist:BAPTA-AM - calcium chelator|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line) - 2007/11/22 2014/10/16 rogid:MW9cTeqVhD4fqlQeS6iYSsVrLHw10029 rogid:4Uxb5gxZ6r4nvVabYkb4qw8WIYg10029 intact-crc:D2F2C55CE126D577|rigid:uxUT4kUgnwnvKSgtTk2y2itJU9g false tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A0A3L7I3A5 uniprotkb:A0A3L7IKR8 intact:EBI-1557743|ensembl:ENSCGRP00001028028|ensembl:ENSCGRP00015005381 intact:EBI-1557913 psi-mi:a0a3l7i3a5_crigr(display_long)|uniprotkb:Sigma non-opioid intracellular receptor 1(gene name synonym)|uniprotkb:CgPICR_003176(orf name) psi-mi:a0a3l7ikr8_crigr(display_long)|uniprotkb:CgPICR_020497(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Hayashi et al. (2007) imex:IM-12021|pubmed:17981125 taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1557995|imex:IM-12021-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_007623283.1|ensembl:ENSCGRG00001024871(gene)|ensembl:ENSCGRG00015004232(gene)|ensembl:ENSCGRT00001032276(transcript)|ensembl:ENSCGRT00015006650(transcript)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like) interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding) psi-mi:"MI:0469"(intact) - - figure legend:Fig 6C|antagonist:ATP - inhibited binding of Gpr78 but not Itpr3|antagonist:"Thapsigargin (endoplasmic reticulum stress factor)"|antagonist:BAPTA-AM calcium chelator|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line) - 2007/11/22 2014/10/16 rogid:MW9cTeqVhD4fqlQeS6iYSsVrLHw10029 rogid:4Uxb5gxZ6r4nvVabYkb4qw8WIYg10029 intact-crc:232F95A391E25BD0|rigid:BLDMhOsPhOI81OQJqcJa0wmNDiQ false tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A0A3L7I3A5 uniprotkb:G3I8R9 intact:EBI-1557743|ensembl:ENSCGRP00001028028|ensembl:ENSCGRP00015005381 intact:EBI-988311|intact:EBI-1557723 psi-mi:a0a3l7i3a5_crigr(display_long)|uniprotkb:Sigma non-opioid intracellular receptor 1(gene name synonym)|uniprotkb:CgPICR_003176(orf name) psi-mi:bip_crigr(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:I79_019946(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Hayashi et al. (2007) imex:IM-12021|pubmed:17981125 taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1557995|imex:IM-12021-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_007623283.1|ensembl:ENSCGRG00001024871(gene)|ensembl:ENSCGRG00015004232(gene)|ensembl:ENSCGRT00001032276(transcript)|ensembl:ENSCGRT00015006650(transcript)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like) go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|rcsb pdb:5O4P|rcsb pdb:6EOB|rcsb pdb:6EOC|rcsb pdb:6EOE|rcsb pdb:6EOF|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|refseq:NP_001233668.1|interpro:IPR029047|interpro:IPR029048|rcsb pdb:7A4V|rcsb pdb:7A4U|rcsb pdb:6ZYH|interpro:IPR042050|rcsb pdb:6H9U|rcsb pdb:6HA7|rcsb pdb:6HAB|interpro:IPR043129 psi-mi:"MI:0469"(intact) - - figure legend:Fig 6C|antagonist:ATP - inhibited binding of Gpr78 but not Itpr3|antagonist:"Thapsigargin (endoplasmic reticulum stress factor)"|antagonist:BAPTA-AM calcium chelator|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line) - 2007/11/22 2014/10/16 rogid:MW9cTeqVhD4fqlQeS6iYSsVrLHw10029 rogid:JdZKgGCixM5M26SXAYdJMRbHSEE10029 intact-crc:232F95A391E25BD0|rigid:BLDMhOsPhOI81OQJqcJa0wmNDiQ false tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G3I8R9 uniprotkb:O55242 intact:EBI-988311|intact:EBI-1557723 intact:EBI-1557700|uniprotkb:Q9JKU9|ensembl:ENSMUSP00000056027 psi-mi:bip_crigr(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:I79_019946(orf name) psi-mi:sgmr1_mouse(display_long)|uniprotkb:Sigma 1-type opioid receptor(gene name synonym)|uniprotkb:Sigmar1(gene name)|psi-mi:Sigmar1(display_short)|uniprotkb:Oprs1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Hayashi et al. (2007) imex:IM-12021|pubmed:17981125 taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1557791|imex:IM-12021-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|rcsb pdb:5O4P|rcsb pdb:6EOB|rcsb pdb:6EOC|rcsb pdb:6EOE|rcsb pdb:6EOF|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|refseq:NP_001233668.1|interpro:IPR029047|interpro:IPR029048|rcsb pdb:7A4V|rcsb pdb:7A4U|rcsb pdb:6ZYH|interpro:IPR042050|rcsb pdb:6H9U|rcsb pdb:6HA7|rcsb pdb:6HAB|interpro:IPR043129 refseq:NP_035144.1|refseq:NP_001273480.1|refseq:NP_001273467.1|refseq:NP_001273468.1|refseq:NP_001273469.1|refseq:NP_001273470.1|refseq:XP_017175516.1|ensembl:ENSMUSG00000036078(gene)|ensembl:ENSMUST00000059354(transcript)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006869"(lipid transport)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like) psi-mi:"MI:0469"(intact) - - figure legend:Fig 2F|comment:Oprs1 stably associates with Hspa5 over more than 32 hours|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line) - 2007/11/22 2014/10/16 rogid:JdZKgGCixM5M26SXAYdJMRbHSEE10029 rogid:KEY6+88EzI03FH6CSiBPcKYF3Ps10090 intact-crc:30727DBC5F4DA98B|rigid:Aq8sj4ZEA1IA9T1aWQ1vtslHNs0 false - tag:c-c|35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P06761 uniprotkb:Q9R0C9 intact:EBI-916036|ensembl:ENSRNOP00000025064 intact:EBI-1557826|uniprotkb:Q9R1J7|uniprotkb:Q9Z2W2|ensembl:ENSRNOP00000019795 psi-mi:bip_rat(display_long)|uniprotkb:Hspa5(gene name)|psi-mi:Hspa5(display_short)|uniprotkb:Grp78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:Steroidogenesis-activator polypeptide(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym) psi-mi:sgmr1_rat(display_long)|uniprotkb:Sigma 1-type opioid receptor(gene name synonym)|uniprotkb:Sigmar1(gene name)|psi-mi:Sigmar1(display_short)|uniprotkb:Oprs1(gene name synonym) psi-mi:"MI:0096"(pull down) Hayashi et al. (2007) imex:IM-12021|pubmed:17981125 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1557847|imex:IM-12021-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2843|refseq:NP_037215.1|ensembl:ENSRNOG00000018294(gene)|ensembl:ENSRNOT00000025067(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006983"(ER overload response)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P06761|reactome:R-RNO-3371453|reactome:R-RNO-983170 rgd:68364|refseq:NP_112258.1|ensembl:ENSRNOG00000014604(gene)|ensembl:ENSRNOT00000019795(transcript)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006869"(lipid transport)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like) psi-mi:"MI:0469"(intact) - - figure legend:Fig 4E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/11/22 2014/10/16 rogid:5HRXkoNHYJvBA2iejRqltGRdJDw10116 rogid:vmBRHHmEmLai9FHo38yHlnwvEyY10116 intact-crc:7926F4733F1E7F89|rigid:uHQtwmLAL2XmaqcXZAXHfV4QELE false - glutathione s tranferase tag:?-?|sufficient binding region:116-223 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P06761 uniprotkb:Q9R0C9 intact:EBI-916036|ensembl:ENSRNOP00000025064 intact:EBI-1557826|uniprotkb:Q9R1J7|uniprotkb:Q9Z2W2|ensembl:ENSRNOP00000019795 psi-mi:bip_rat(display_long)|uniprotkb:Hspa5(gene name)|psi-mi:Hspa5(display_short)|uniprotkb:Grp78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:Steroidogenesis-activator polypeptide(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym) psi-mi:sgmr1_rat(display_long)|uniprotkb:Sigma 1-type opioid receptor(gene name synonym)|uniprotkb:Sigmar1(gene name)|psi-mi:Sigmar1(display_short)|uniprotkb:Oprs1(gene name synonym) psi-mi:"MI:0096"(pull down) Hayashi et al. (2007) imex:IM-12021|pubmed:17981125 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1557863|imex:IM-12021-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2843|refseq:NP_037215.1|ensembl:ENSRNOG00000018294(gene)|ensembl:ENSRNOT00000025067(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006983"(ER overload response)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P06761|reactome:R-RNO-3371453|reactome:R-RNO-983170 rgd:68364|refseq:NP_112258.1|ensembl:ENSRNOG00000014604(gene)|ensembl:ENSRNOT00000019795(transcript)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006869"(lipid transport)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like) psi-mi:"MI:0469"(intact) - - figure legend:Fig 4E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/11/22 2014/10/16 rogid:5HRXkoNHYJvBA2iejRqltGRdJDw10116 rogid:vmBRHHmEmLai9FHo38yHlnwvEyY10116 intact-crc:339A440320B832F9|rigid:uHQtwmLAL2XmaqcXZAXHfV4QELE false - glutathione s tranferase tag:?-?|sufficient binding region:116-223 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9R0C9 uniprotkb:P06761 intact:EBI-1557826|uniprotkb:Q9R1J7|uniprotkb:Q9Z2W2|ensembl:ENSRNOP00000019795 intact:EBI-916036|ensembl:ENSRNOP00000025064 psi-mi:sgmr1_rat(display_long)|uniprotkb:Sigma 1-type opioid receptor(gene name synonym)|uniprotkb:Sigmar1(gene name)|psi-mi:Sigmar1(display_short)|uniprotkb:Oprs1(gene name synonym) psi-mi:bip_rat(display_long)|uniprotkb:Hspa5(gene name)|psi-mi:Hspa5(display_short)|uniprotkb:Grp78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:Steroidogenesis-activator polypeptide(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym) psi-mi:"MI:0096"(pull down) Hayashi et al. (2007) imex:IM-12021|pubmed:17981125 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1557872|imex:IM-12021-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:68364|refseq:NP_112258.1|ensembl:ENSRNOG00000014604(gene)|ensembl:ENSRNOT00000019795(transcript)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006869"(lipid transport)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like) rgd:2843|refseq:NP_037215.1|ensembl:ENSRNOG00000018294(gene)|ensembl:ENSRNOT00000025067(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006983"(ER overload response)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P06761|reactome:R-RNO-3371453|reactome:R-RNO-983170 psi-mi:"MI:0469"(intact) - - figure legend:Fig 4E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/11/22 2014/10/16 rogid:vmBRHHmEmLai9FHo38yHlnwvEyY10116 rogid:5HRXkoNHYJvBA2iejRqltGRdJDw10116 intact-crc:3EB44CD1DDFDD4D7|rigid:uHQtwmLAL2XmaqcXZAXHfV4QELE false glutathione s tranferase tag:?-?|sufficient binding region:116-223 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9R0C9 uniprotkb:G3I8R9 intact:EBI-1557826|uniprotkb:Q9R1J7|uniprotkb:Q9Z2W2|ensembl:ENSRNOP00000019795 intact:EBI-988311|intact:EBI-1557723 psi-mi:sgmr1_rat(display_long)|uniprotkb:Sigma 1-type opioid receptor(gene name synonym)|uniprotkb:Sigmar1(gene name)|psi-mi:Sigmar1(display_short)|uniprotkb:Oprs1(gene name synonym) psi-mi:bip_crigr(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:I79_019946(orf name) psi-mi:"MI:0096"(pull down) Hayashi et al. (2007) imex:IM-12021|pubmed:17981125 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1557888|imex:IM-12021-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:68364|refseq:NP_112258.1|ensembl:ENSRNOG00000014604(gene)|ensembl:ENSRNOT00000019795(transcript)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006869"(lipid transport)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like) go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|rcsb pdb:5O4P|rcsb pdb:6EOB|rcsb pdb:6EOC|rcsb pdb:6EOE|rcsb pdb:6EOF|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|refseq:NP_001233668.1|interpro:IPR029047|interpro:IPR029048|rcsb pdb:7A4V|rcsb pdb:7A4U|rcsb pdb:6ZYH|interpro:IPR042050|rcsb pdb:6H9U|rcsb pdb:6HA7|rcsb pdb:6HAB|interpro:IPR043129 psi-mi:"MI:0469"(intact) - - figure legend:Fig 4E, 4F|agonist:Ca2+, Mn2+|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/11/22 2014/10/16 rogid:vmBRHHmEmLai9FHo38yHlnwvEyY10116 rogid:JdZKgGCixM5M26SXAYdJMRbHSEE10029 intact-crc:C516AF8EDAED275D|rigid:6u30KOpQEDL79eP535zcPJVNXWI false glutathione s tranferase tag:?-?|sufficient binding region:116-223 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A0A3L7I3A5 uniprotkb:A0A3L7IKR8 intact:EBI-1557743|ensembl:ENSCGRP00001028028|ensembl:ENSCGRP00015005381 intact:EBI-1557913 psi-mi:a0a3l7i3a5_crigr(display_long)|uniprotkb:Sigma non-opioid intracellular receptor 1(gene name synonym)|uniprotkb:CgPICR_003176(orf name) psi-mi:a0a3l7ikr8_crigr(display_long)|uniprotkb:CgPICR_020497(orf name) psi-mi:"MI:0416"(fluorescence microscopy) Hayashi et al. (2007) imex:IM-12021|pubmed:17981125 taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-1557984|imex:IM-12021-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_007623283.1|ensembl:ENSCGRG00001024871(gene)|ensembl:ENSCGRG00015004232(gene)|ensembl:ENSCGRT00001032276(transcript)|ensembl:ENSCGRT00015006650(transcript)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like) interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding) go:"GO:0005789"(endoplasmic reticulum membrane) - - figure legend:Fig 6A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line) - 2007/11/22 2014/10/16 rogid:MW9cTeqVhD4fqlQeS6iYSsVrLHw10029 rogid:4Uxb5gxZ6r4nvVabYkb4qw8WIYg10029 intact-crc:7AC42C060CFEAAAB|rigid:uxUT4kUgnwnvKSgtTk2y2itJU9g false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)