#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9Z261 uniprotkb:Q80UE6 intact:EBI-7158849|ensembl:ENSMUSP00000018713|ensembl:ENSMUSP00000104238|intact:MINT-113113|uniprotkb:Q3TJX4 intact:EBI-295378|uniprotkb:Q4VAC1|uniprotkb:Q80XB5|uniprotkb:Q80XN2|uniprotkb:Q8R0N0|uniprotkb:Q8R340|uniprotkb:A2A4J7|ensembl:ENSMUSP00000099397 psi-mi:cld7_mouse(display_long)|uniprotkb:Cldn7(gene name)|psi-mi:Cldn7(display_short) psi-mi:wnk4_mouse(display_long)|uniprotkb:Wnk4(gene name)|psi-mi:Wnk4(display_short)|uniprotkb:Prkwnk4(gene name synonym)|uniprotkb:Protein kinase with no lysine 4(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 4(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Tatum et al. (2007) pubmed:17651736|imex:IM-11367|mint:MINT-5220104 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7510631|mint:MINT-4980925|imex:IM-11367-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000018569(gene)|ensembl:ENSMUST00000018713(transcript)|ensembl:ENSMUST00000108597(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016338"(calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR003552(Claudin-7)|interpro:IPR004031(PMP-22/EMP/MP20/Claudin)|interpro:IPR006187(Claudin)|interpro:IPR017974|mint:Q9Z261|refseq:NP_001180548.1|refseq:NP_058583.1|mint:MINT-4980926(identity) refseq:NP_783569.1|dip:DIP-33231N|ensembl:ENSMUSG00000035112(gene)|ensembl:ENSMUST00000103108(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0008104"(protein localization)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0072156"(distal tubule morphogenesis)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|mint:Q80UE6|reactome:R-MMU-2672351|mint:MINT-4980927(identity) - comment:mint|function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity - figure legend:F2B|comment:Claudin-7 is identified by a murine SP_id since the pig version of the protein is not available|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-ln_229)|taxid:9823(Sus scrofa) - 2007/09/11 2014/10/16 rogid:5JvaG/Faus04JjxlMl/ZcFshUZs10090 rogid:Djz8WcXVZvZ4fNqMjyR9lPdOL2A10090 intact-crc:79F3E72228475C6B|rigid:XyiiHT61POAxKEuHkEZX3fdlfMQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0072"(monoclonal antibody western blot)