#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9UBX5 uniprotkb:Q14767 intact:EBI-947897|uniprotkb:O75966|uniprotkb:Q6UWA3|uniprotkb:Q6IAL4|ensembl:ENSP00000345008 intact:EBI-1546118|uniprotkb:Q99907|uniprotkb:Q9NS51|ensembl:ENSP00000261978 psi-mi:fbln5_human(display_long)|uniprotkb:Developmental arteries and neural crest EGF-like protein(gene name synonym)|uniprotkb:Urine p50 protein(gene name synonym)|uniprotkb:FBLN5(gene name)|psi-mi:FBLN5(display_short)|uniprotkb:DANCE(gene name synonym)|uniprotkb:UNQ184/PRO210(orf name) psi-mi:ltbp2_human(display_long)|uniprotkb:C14orf141(gene name synonym)|uniprotkb:LTBP2(gene name)|psi-mi:LTBP2(display_short)|uniprotkb:LTBP3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Hirai et al. (2007) pubmed:17581631|imex:IM-10985|mint:MINT-5220035 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7465573|mint:MINT-5115583|imex:IM-10985-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006320.2|dip:DIP-44301N|ensembl:ENSG00000140092(gene)|ensembl:ENST00000342058(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046903"(secretion)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR037288|mint:Q9UBX5|reactome:R-HSA-1566948|reactome:R-HSA-2129379|mint:MINT-5115584(identity) refseq:NP_000419.1|ensembl:ENSG00000119681(gene)|ensembl:ENST00000261978(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006605"(protein targeting)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0009306"(protein secretion)|go:"GO:0019838"(growth factor binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0050436"(microfibril binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097435"(supramolecular fiber organization)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017878|interpro:IPR018097|interpro:IPR036773|mint:Q14767|reactome:R-HSA-2129379|mint:MINT-5115585(identity) - - - figure legend:F2B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2007/09/19 2014/10/16 rogid:1fqx+PBkfO9F1/5wXcNasL9R8Mk9606 rogid:wVHOgbtH2VvefjwD6HUjforUFXM9606 intact-crc:C85E828FB78EBC1F|rigid:rdUIZO1axv44s8vIh6AZXl9cGm0 false flag tag:?-?(MINT-5115589)|binding-associated region:288-333(MINT-5115594) myc tag:?-?(MINT-5115599) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UBX5 uniprotkb:Q14767 intact:EBI-947897|uniprotkb:O75966|uniprotkb:Q6UWA3|uniprotkb:Q6IAL4|ensembl:ENSP00000345008 intact:EBI-1546118|uniprotkb:Q99907|uniprotkb:Q9NS51|ensembl:ENSP00000261978 psi-mi:fbln5_human(display_long)|uniprotkb:Developmental arteries and neural crest EGF-like protein(gene name synonym)|uniprotkb:Urine p50 protein(gene name synonym)|uniprotkb:FBLN5(gene name)|psi-mi:FBLN5(display_short)|uniprotkb:DANCE(gene name synonym)|uniprotkb:UNQ184/PRO210(orf name) psi-mi:ltbp2_human(display_long)|uniprotkb:C14orf141(gene name synonym)|uniprotkb:LTBP2(gene name)|psi-mi:LTBP2(display_short)|uniprotkb:LTBP3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Hirai et al. (2007) pubmed:17581631|imex:IM-10985|mint:MINT-5220035 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7465637|mint:MINT-5115605|imex:IM-10985-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006320.2|dip:DIP-44301N|ensembl:ENSG00000140092(gene)|ensembl:ENST00000342058(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046903"(secretion)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR037288|mint:Q9UBX5|reactome:R-HSA-1566948|reactome:R-HSA-2129379|mint:MINT-5115606(identity) refseq:NP_000419.1|ensembl:ENSG00000119681(gene)|ensembl:ENST00000261978(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006605"(protein targeting)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0009306"(protein secretion)|go:"GO:0019838"(growth factor binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0050436"(microfibril binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097435"(supramolecular fiber organization)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017878|interpro:IPR018097|interpro:IPR036773|mint:Q14767|reactome:R-HSA-2129379|mint:MINT-5115616(identity) - - - figure legend:F3B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2007/09/19 2014/10/16 rogid:1fqx+PBkfO9F1/5wXcNasL9R8Mk9606 rogid:wVHOgbtH2VvefjwD6HUjforUFXM9606 intact-crc:29DF56E8A6ED4A80|rigid:rdUIZO1axv44s8vIh6AZXl9cGm0 false myc tag:?-?(MINT-5115613) flag tag:?-?(MINT-5115619) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O08999 uniprotkb:Q9WVH9 intact:EBI-7465667|intact:MINT-4100636|uniprotkb:Q8C6W9 intact:EBI-7465688|intact:MINT-4094993|uniprotkb:Q541Z7|ensembl:ENSMUSP00000021603 psi-mi:ltbp2_mouse(display_long)|uniprotkb:Ltbp2(gene name)|psi-mi:Ltbp2(display_short) psi-mi:fbln5_mouse(display_long)|uniprotkb:Fbln5(gene name)|psi-mi:Fbln5(display_short)|uniprotkb:Dance(gene name synonym)|uniprotkb:Developmental arteries and neural crest EGF-like protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Hirai et al. (2007) pubmed:17581631|imex:IM-10985|mint:MINT-5220035 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7465717|mint:MINT-5115631|imex:IM-10985-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:O08999|interpro:IPR036773|interpro:IPR017878|interpro:IPR018097|refseq:NP_038617.3|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0008201"(heparin binding)|go:"GO:0019838"(growth factor binding)|go:"GO:0050436"(microfibril binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097435"(supramolecular fiber organization)|reactome:R-MMU-2129379|mint:MINT-5115638(identity) refseq:NP_035942.1|ensembl:ENSMUSG00000021186(gene)|ensembl:ENSMUST00000021603(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046903"(secretion)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098867"(intramembranous bone growth)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR037288|mint:Q9WVH9|reactome:R-MMU-1566948|reactome:R-MMU-2129379|mint:MINT-5115632(identity) - comment:mint|function:"May play an integral structural role in elastic-fiber architectural organization and/or assembly. May be involved in the assembly, secretion and targeting of TGF- beta to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGF-beta. May have a structural role in the extra cellular matrix (ECM)" function:Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling|comment:mint figure legend:F5|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-lung)|taxid:10090(Mus musculus) - 2007/09/19 2014/10/16 rogid:r2llFqtK2ydvhtLZB7d1pAfSk4410090 rogid:qSEP5mtYIyyHhSVNnG0DkIirMUc10090 intact-crc:F8DBE83FF347DDEA|rigid:UQkvJQgwBJeiqrxK9KuceIqrT6Q false - - - - psi-mi:"MI:0709"(polyclonal antibody immunostaining) psi-mi:"MI:0113"(western blot)