#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q16695	uniprotkb:O75164	intact:EBI-358900|uniprotkb:Q6FGU4|uniprotkb:B2R5K3|ensembl:ENSP00000355657|ensembl:ENSP00000494070	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	psi-mi:h31t_human(display_long)|uniprotkb:H3-4(gene name)|psi-mi:H3-4(display_short)|uniprotkb:H3/g(gene name synonym)|uniprotkb:H3FT(gene name synonym)|uniprotkb:HIST3H3(gene name synonym)|uniprotkb:Histone H3.4(gene name synonym)	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Chen et al. (2007)	pubmed:17567753|imex:IM-22866	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-1268500|wwpdb:2pxj|imex:IM-22866-1|dip:DIP-196924E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003484.1|ensembl:ENSG00000168148(gene)|ensembl:ENSG00000285435(gene)|ensembl:ENST00000366696(transcript)|ensembl:ENST00000644869(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:Q16695|rcsb pdb:2V1D|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3A6N|rcsb pdb:3T6R|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:6OIE|rcsb pdb:6WAT|rcsb pdb:6WAU|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-201722|reactome:R-HSA-2299718|reactome:R-HSA-2559586|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-9670095|dip:DIP-922N	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	psi-mi:"MI:0465"(dip)	-	-	3d-r-factors:working 25.6%, free 27.6%|3d-resolution:2.00 A|figure legend:Table S1, Figure 1|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/06/26	2017/06/30	rogid:izXHIcNCPCDQ7yevMtqWxTRt1bA9606	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	intact-crc:A344EC0A1F906438|rigid:WcrYDp+Q26waPepwGioWq7mZHlc	false	N6-methyl-L-lysine:36-36|sufficient binding region:27-49	sufficient binding region:2-348	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16695	uniprotkb:O75164	intact:EBI-358900|uniprotkb:Q6FGU4|uniprotkb:B2R5K3|ensembl:ENSP00000355657|ensembl:ENSP00000494070	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	psi-mi:h31t_human(display_long)|uniprotkb:H3-4(gene name)|psi-mi:H3-4(display_short)|uniprotkb:H3/g(gene name synonym)|uniprotkb:H3FT(gene name synonym)|uniprotkb:HIST3H3(gene name synonym)|uniprotkb:Histone H3.4(gene name synonym)	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Chen et al. (2007)	pubmed:17567753|imex:IM-22866	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-1270721|wwpdb:2p5b|imex:IM-22866-2|dip:DIP-196924E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003484.1|ensembl:ENSG00000168148(gene)|ensembl:ENSG00000285435(gene)|ensembl:ENST00000366696(transcript)|ensembl:ENST00000644869(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:Q16695|rcsb pdb:2V1D|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3A6N|rcsb pdb:3T6R|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:6OIE|rcsb pdb:6WAT|rcsb pdb:6WAU|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-201722|reactome:R-HSA-2299718|reactome:R-HSA-2559586|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-9670095|dip:DIP-922N	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	psi-mi:"MI:0465"(dip)	-	-	3d-r-factors:working 23.8%, free 26.3%|3d-resolution:1.99 A|figure legend:Table 1, Figure 1|caution:Peptide is Lys is position 48 of the protein, whereas UniProt has Ala at this position.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/06/26	2017/06/30	rogid:izXHIcNCPCDQ7yevMtqWxTRt1bA9606	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	intact-crc:969A43FBC9370405|rigid:WcrYDp+Q26waPepwGioWq7mZHlc	false	N6,N6,N6-trimethyl-L-lysine:36-36|sufficient binding region:27-48|mutation:48-48	sufficient binding region:2-348	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16695	uniprotkb:O75164	intact:EBI-358900|uniprotkb:Q6FGU4|uniprotkb:B2R5K3|ensembl:ENSP00000355657|ensembl:ENSP00000494070	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	psi-mi:h31t_human(display_long)|uniprotkb:H3-4(gene name)|psi-mi:H3-4(display_short)|uniprotkb:H3/g(gene name synonym)|uniprotkb:H3FT(gene name synonym)|uniprotkb:HIST3H3(gene name synonym)|uniprotkb:Histone H3.4(gene name synonym)	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:"MI:0870"(demethylase assay)	Chen et al. (2007)	pubmed:17567753|imex:IM-22866	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0871"(demethylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-1268494|imex:IM-22866-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003484.1|ensembl:ENSG00000168148(gene)|ensembl:ENSG00000285435(gene)|ensembl:ENST00000366696(transcript)|ensembl:ENST00000644869(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:Q16695|rcsb pdb:2V1D|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3A6N|rcsb pdb:3T6R|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:6OIE|rcsb pdb:6WAT|rcsb pdb:6WAU|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-201722|reactome:R-HSA-2299718|reactome:R-HSA-2559586|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-9670095|dip:DIP-922N	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	go:"GO:0032452"(histone demethylase activity)	-	-	figure legend:2|comment:Mutagenesis data and activity assays suggest residues Q86, N88, D135, and Y175 are involved in the interaction with the peptide, whereas residues Y177, N290, S288, and T289 are involved in methyl group binding. K241 is proposed to recruit the O2 molecule into the catalytic center.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/06/26	2017/06/30	rogid:izXHIcNCPCDQ7yevMtqWxTRt1bA9606	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	intact-crc:AB17DB1BAE19A5F5|rigid:WcrYDp+Q26waPepwGioWq7mZHlc	false	N6,N6,N6-trimethyl-L-lysine:36-36|sufficient binding region:27-48	mutation decreasing interaction:86-86|mutation decreasing interaction:88-88|mutation decreasing interaction:135-135|mutation decreasing interaction:175-175|mutation decreasing interaction:177-177|mutation disrupting interaction:241-241|mutation disrupting interaction:177-177|mutation disrupting interaction:241-241|mutation disrupting interaction:290-290|mutation disrupting interaction:290-290|mutation disrupting interaction:290-290|mutation disrupting interaction:290-290	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q16695	uniprotkb:O75164	intact:EBI-358900|uniprotkb:Q6FGU4|uniprotkb:B2R5K3|ensembl:ENSP00000355657|ensembl:ENSP00000494070	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	psi-mi:h31t_human(display_long)|uniprotkb:H3-4(gene name)|psi-mi:H3-4(display_short)|uniprotkb:H3/g(gene name synonym)|uniprotkb:H3FT(gene name synonym)|uniprotkb:HIST3H3(gene name synonym)|uniprotkb:Histone H3.4(gene name synonym)	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:"MI:0870"(demethylase assay)	Chen et al. (2007)	pubmed:17567753|imex:IM-22866	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0871"(demethylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-1270771|imex:IM-22866-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003484.1|ensembl:ENSG00000168148(gene)|ensembl:ENSG00000285435(gene)|ensembl:ENST00000366696(transcript)|ensembl:ENST00000644869(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:Q16695|rcsb pdb:2V1D|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3A6N|rcsb pdb:3T6R|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:6OIE|rcsb pdb:6WAT|rcsb pdb:6WAU|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-201722|reactome:R-HSA-2299718|reactome:R-HSA-2559586|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-9670095|dip:DIP-922N	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	go:"GO:0032452"(histone demethylase activity)	-	-	figure legend:2|comment:Mutagenesis data and activity assays suggest residues Q86, N88, D135, and Y175 are involved in the interaction with the peptide, whereas residues Y177, N290, S288, and T289 are involved in methyl group binding. K241 is proposed to recruit the O2 molecule into the catalytic center.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/06/26	2017/06/30	rogid:izXHIcNCPCDQ7yevMtqWxTRt1bA9606	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	intact-crc:48D05CAFECFB9C25|rigid:WcrYDp+Q26waPepwGioWq7mZHlc	false	sufficient binding region:2-23|N6,N6,N6-trimethyl-L-lysine:9-9	mutation decreasing interaction:86-86|mutation decreasing interaction:88-88|mutation decreasing interaction:135-135|mutation decreasing interaction:175-175|mutation decreasing interaction:177-177|mutation disrupting interaction:241-241|mutation disrupting interaction:177-177|mutation disrupting interaction:241-241|mutation disrupting interaction:290-290|mutation disrupting interaction:290-290|mutation disrupting interaction:290-290|mutation disrupting interaction:290-290	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q16695	uniprotkb:O75164	intact:EBI-358900|uniprotkb:Q6FGU4|uniprotkb:B2R5K3|ensembl:ENSP00000355657|ensembl:ENSP00000494070	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	psi-mi:h31t_human(display_long)|uniprotkb:H3-4(gene name)|psi-mi:H3-4(display_short)|uniprotkb:H3/g(gene name synonym)|uniprotkb:H3FT(gene name synonym)|uniprotkb:HIST3H3(gene name synonym)|uniprotkb:Histone H3.4(gene name synonym)	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2007)	pubmed:17567753|imex:IM-22866	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-1270815|dip:DIP-196925E|imex:IM-22866-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003484.1|ensembl:ENSG00000168148(gene)|ensembl:ENSG00000285435(gene)|ensembl:ENST00000366696(transcript)|ensembl:ENST00000644869(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:Q16695|rcsb pdb:2V1D|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3A6N|rcsb pdb:3T6R|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:6OIE|rcsb pdb:6WAT|rcsb pdb:6WAU|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-201722|reactome:R-HSA-2299718|reactome:R-HSA-2559586|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-9670095|dip:DIP-922N	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	psi-mi:"MI:0465"(dip)	-	-	figure legend:2C|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/06/26	2017/06/30	rogid:izXHIcNCPCDQ7yevMtqWxTRt1bA9606	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	intact-crc:4CAA5F03E5D0B16E|rigid:WcrYDp+Q26waPepwGioWq7mZHlc	false	N6,N6,N6-trimethyl-L-lysine:36-36|sufficient binding region:27-47	sufficient binding region:2-348	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16695	uniprotkb:O75164	intact:EBI-358900|uniprotkb:Q6FGU4|uniprotkb:B2R5K3|ensembl:ENSP00000355657|ensembl:ENSP00000494070	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	psi-mi:h31t_human(display_long)|uniprotkb:H3-4(gene name)|psi-mi:H3-4(display_short)|uniprotkb:H3/g(gene name synonym)|uniprotkb:H3FT(gene name synonym)|uniprotkb:HIST3H3(gene name synonym)|uniprotkb:Histone H3.4(gene name synonym)	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Chen et al. (2007)	pubmed:17567753|imex:IM-22866	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-1270824|imex:IM-22866-3|dip:DIP-196924E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003484.1|ensembl:ENSG00000168148(gene)|ensembl:ENSG00000285435(gene)|ensembl:ENST00000366696(transcript)|ensembl:ENST00000644869(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:Q16695|rcsb pdb:2V1D|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3A6N|rcsb pdb:3T6R|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:6OIE|rcsb pdb:6WAT|rcsb pdb:6WAU|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-201722|reactome:R-HSA-2299718|reactome:R-HSA-2559586|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-9670095|dip:DIP-922N	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	psi-mi:"MI:0465"(dip)	-	-	figure legend:2D|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/06/26	2017/06/30	rogid:izXHIcNCPCDQ7yevMtqWxTRt1bA9606	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	intact-crc:35140488D561E5F9|rigid:WcrYDp+Q26waPepwGioWq7mZHlc	false	sufficient binding region:2-23|N6,N6,N6-trimethyl-L-lysine:9-9	sufficient binding region:2-348|mutation disrupting interaction strength:133-133,138-138|mutation disrupting interaction strength:165-165,170-170	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)