#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P49407	uniprotkb:P30556	intact:EBI-743313|uniprotkb:O75625|uniprotkb:O75630|uniprotkb:Q2PP20|uniprotkb:Q9BTK8|intact:EBI-2561130|uniprotkb:B6V9G8|ensembl:ENSP00000409581	intact:EBI-6623016|uniprotkb:Q8TBK4|ensembl:ENSP00000273430|ensembl:ENSP00000385612|ensembl:ENSP00000418084|ensembl:ENSP00000418851|ensembl:ENSP00000419422|ensembl:ENSP00000419783|ensembl:ENSP00000385641|ensembl:ENSP00000398832|uniprotkb:Q13725	psi-mi:arrb1_human(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:ARRB1(gene name)|psi-mi:ARRB1(display_short)|uniprotkb:ARR1(gene name synonym)|uniprotkb:Non-visual arrestin-2(gene name synonym)	psi-mi:agtr1_human(display_long)|uniprotkb:AGTR1(gene name)|psi-mi:AGTR1(display_short)|uniprotkb:AGTR1A(gene name synonym)|uniprotkb:AGTR1B(gene name synonym)|uniprotkb:AT2R1(gene name synonym)|uniprotkb:AT2R1B(gene name synonym)|uniprotkb:AT1AR(gene name synonym)|uniprotkb:AT1BR(gene name synonym)|uniprotkb:Angiotensin II type-1 receptor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lee et al. (2007)	pubmed:17498700|imex:IM-11093|mint:MINT-5219925	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7409701|mint:MINT-4791905|imex:IM-11093-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004032.2|refseq:NP_064647.1|ensembl:ENSG00000137486(gene)|ensembl:ENST00000420843(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016573"(histone acetylation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042493"|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:P49407|rcsb pdb:2IV8|rcsb pdb:6PWC|rcsb pdb:6TKO|rcsb pdb:6UP7|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-456926|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|dip:DIP-29979N|mint:MINT-4791907(identity)	refseq:NP_114038.4|refseq:NP_114438.2|ensembl:ENSG00000144891(gene)|ensembl:ENST00000349243(transcript)|ensembl:ENST00000402260(transcript)|ensembl:ENST00000404754(transcript)|ensembl:ENST00000461609(transcript)|ensembl:ENST00000474935(transcript)|ensembl:ENST00000475347(transcript)|ensembl:ENST00000497524(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001822"(kidney development)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|ensembl:ENST00000418473(transcript)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30556|rcsb pdb:1ZV0|rcsb pdb:4YAY|rcsb pdb:4ZUD|rcsb pdb:6DO1|rcsb pdb:6OS0|rcsb pdb:6OS1|rcsb pdb:6OS2|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0019229"(regulation of vasoconstriction)|refseq:NP_004826.5|refseq:NP_000676.1|refseq:NP_033611.1|mint:MINT-4791906(identity)	-	-	-	figure legend:F3A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2007/06/06	2014/10/16	rogid:UNYbZY5saRx8CwJ8Jwt3QtjXgj09606	rogid:hrgCoboCmBvuoZEj5YuPnL+KuEQ9606	intact-crc:B57004F0248D113D|rigid:+gv0+fup2Me8K5r6fPzXg++wy6c	false	-	mutation decreasing interaction:111-111(MINT-4791914)|ha tag:?-?(MINT-4794586)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P50148	uniprotkb:P30556	intact:EBI-3909604|uniprotkb:Q6NT27|uniprotkb:Q92471|uniprotkb:O15108|uniprotkb:Q9BZB9|uniprotkb:Q13462|ensembl:ENSP00000286548	intact:EBI-6623016|uniprotkb:Q8TBK4|ensembl:ENSP00000273430|ensembl:ENSP00000385612|ensembl:ENSP00000418084|ensembl:ENSP00000418851|ensembl:ENSP00000419422|ensembl:ENSP00000419783|ensembl:ENSP00000385641|ensembl:ENSP00000398832|uniprotkb:Q13725	psi-mi:gnaq_human(display_long)|uniprotkb:GNAQ(gene name)|psi-mi:GNAQ(display_short)|uniprotkb:GAQ(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein alpha-q(gene name synonym)	psi-mi:agtr1_human(display_long)|uniprotkb:AGTR1(gene name)|psi-mi:AGTR1(display_short)|uniprotkb:AGTR1A(gene name synonym)|uniprotkb:AGTR1B(gene name synonym)|uniprotkb:AT2R1(gene name synonym)|uniprotkb:AT2R1B(gene name synonym)|uniprotkb:AT1AR(gene name synonym)|uniprotkb:AT1BR(gene name synonym)|uniprotkb:Angiotensin II type-1 receptor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lee et al. (2007)	pubmed:17498700|imex:IM-11093|mint:MINT-5219925	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7409738|mint:MINT-4791922|imex:IM-11093-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002063.2|ensembl:ENSG00000156052(gene)|ensembl:ENST00000286548(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P50148|rcsb pdb:6VU5|reactome:R-HSA-112043|reactome:R-HSA-202040|reactome:R-HSA-399997|reactome:R-HSA-416476|reactome:R-HSA-418592|reactome:R-HSA-428930|reactome:R-HSA-434316|reactome:R-HSA-456926|reactome:R-HSA-6814122|dip:DIP-41652N|mint:MINT-4791923(identity)	refseq:NP_114038.4|refseq:NP_114438.2|ensembl:ENSG00000144891(gene)|ensembl:ENST00000349243(transcript)|ensembl:ENST00000402260(transcript)|ensembl:ENST00000404754(transcript)|ensembl:ENST00000461609(transcript)|ensembl:ENST00000474935(transcript)|ensembl:ENST00000475347(transcript)|ensembl:ENST00000497524(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001822"(kidney development)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|ensembl:ENST00000418473(transcript)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30556|rcsb pdb:1ZV0|rcsb pdb:4YAY|rcsb pdb:4ZUD|rcsb pdb:6DO1|rcsb pdb:6OS0|rcsb pdb:6OS1|rcsb pdb:6OS2|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0019229"(regulation of vasoconstriction)|refseq:NP_004826.5|refseq:NP_000676.1|refseq:NP_033611.1|mint:MINT-4791927(identity)	-	-	-	figure legend:F2A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2007/06/06	2014/10/16	rogid:ExDRSmmaTXllLWSDrc79rkxxAqQ9606	rogid:hrgCoboCmBvuoZEj5YuPnL+KuEQ9606	intact-crc:761ADF89A84AC777|rigid:/xSZQh3Bk2qEvz6/KMM51GD5Rm4	false	-	ha tag:?-?(MINT-4794589)|mutation increasing interaction:111-111(MINT-4791928)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0705"(anti tag western blot)