#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8CGE9	uniprotkb:Q6PFD5	intact:EBI-7340552|intact:MINT-4115792|uniprotkb:E9PXX2|ensembl:ENSMUSP00000030984	intact:EBI-2308733|uniprotkb:Q6PDX0|uniprotkb:Q6XBF2|ensembl:ENSMUSP00000039724|ensembl:ENSMUSP00000101700	psi-mi:rgs12_mouse(display_long)|uniprotkb:Rgs12(gene name)|psi-mi:Rgs12(display_short)	psi-mi:dlgp3_mouse(display_long)|uniprotkb:Dlgap3(gene name)|psi-mi:Dlgap3(display_short)|uniprotkb:Dap3(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 3(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Willard et al. (2007)	pubmed:17380122|imex:IM-11437|mint:MINT-5219791	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7340545|mint:MINT-4789713|imex:IM-11437-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_775578.2|ensembl:ENSMUSG00000029101(gene)|ensembl:ENSMUST00000030984(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038032"(termination of G protein-coupled receptor signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0097440"(apical dendrite)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003109(GoLoco)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR036034|interpro:IPR036305|interpro:IPR037880|mint:Q8CGE9|reactome:R-MMU-418594|mint:MINT-4789714(identity)	refseq:XP_011238839.1|refseq:NP_941020.1|refseq:NP_001289010.1|ensembl:ENSMUSG00000042388(gene)|ensembl:ENSMUST00000046659(transcript)|ensembl:ENSMUST00000106094(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0023052"(signaling)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030526|mint:Q6PFD5|rcsb pdb:5IZU|reactome:R-MMU-6794361|mint:MINT-4789715(identity)	-	comment:mint	-	figure legend:SF1A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2007/06/04	2014/10/16	rogid:py2jNyvxGHKC0cnn2YcrPpvXfd410090	rogid:mkXYwYR5Snou4RA8d71UDC7G59I10090	intact-crc:4C575A59A11BE314|rigid:jFtRKiCQjzdylhfuHzY8uke5yYs	false	binding-associated region:1-369(MINT-4789801)|tag:?-?(MINT-4789719)	tag:?-?(MINT-4789729)|binding-associated region:814-977(MINT-4789734)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKT4	uniprotkb:P63208	intact:EBI-852298|uniprotkb:Q8WV29|uniprotkb:Q9UGC8|uniprotkb:B3KNX5|uniprotkb:Q5TF47|ensembl:ENSP00000229758	intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961	psi-mi:fbx5_human(display_long)|uniprotkb:FBXO5(gene name)|psi-mi:FBXO5(display_short)|uniprotkb:EMI1(gene name synonym)|uniprotkb:FBX5(gene name synonym)|uniprotkb:Early mitotic inhibitor 1(gene name synonym)	psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Willard et al. (2007)	pubmed:17380122|imex:IM-11437|mint:MINT-5219791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7340731|mint:MINT-4789761|imex:IM-11437-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135994.1|refseq:NP_036309.1|dip:DIP-38023N|ensembl:ENSG00000112029(gene)|ensembl:ENST00000229758(transcript)|go:"GO:0001556"(oocyte maturation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016050"(vesicle organization)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032876"(negative regulation of DNA endoreduplication)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0045841"(negative regulation of mitotic metaphase/anaphase transition)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0072687"(meiotic spindle)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001021"(negative regulation of response to DNA damage stimulus)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR044064|mint:Q9UKT4|rcsb pdb:2M6N|rcsb pdb:4UI9|reactome:R-HSA-174113|reactome:R-HSA-176408|reactome:R-HSA-176417|reactome:R-HSA-68881|reactome:R-HSA-69205|mint:MINT-4789768(identity)	reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N|mint:MINT-4789762(identity)	-	-	-	figure legend:SF1A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2007/06/04	2014/10/16	rogid:6NU7FdV1cnJsK3TuNKMdirgBhVM9606	rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606	intact-crc:4349A5732A727D6C|rigid:vhKWXeg82OJsAthhx8GfpUQXogU	false	tag:?-?(MINT-4789773)	tag:?-?(MINT-4789765)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8CGE9	uniprotkb:Q63932	intact:EBI-7340552|intact:MINT-4115792|uniprotkb:E9PXX2|ensembl:ENSMUSP00000030984	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	psi-mi:rgs12_mouse(display_long)|uniprotkb:Rgs12(gene name)|psi-mi:Rgs12(display_short)	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Willard et al. (2007)	pubmed:17380122|imex:IM-11437|mint:MINT-5219791	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7340684|mint:MINT-4789740|imex:IM-11437-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_775578.2|ensembl:ENSMUSG00000029101(gene)|ensembl:ENSMUST00000030984(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038032"(termination of G protein-coupled receptor signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0097440"(apical dendrite)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003109(GoLoco)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR036034|interpro:IPR036305|interpro:IPR037880|mint:Q8CGE9|reactome:R-MMU-418594|mint:MINT-4789749(identity)	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N|mint:MINT-4789741(identity)	-	comment:mint	-	figure legend:SF1A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2007/06/04	2014/10/16	rogid:py2jNyvxGHKC0cnn2YcrPpvXfd410090	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	intact-crc:373D9819D4D815E3|rigid:t/OJ8H2o8ro4lv3QRx6Y50g7xpQ	false	tag:?-?(MINT-4789754)|binding-associated region:1-369(MINT-4789750)	binding-associated region:324-401(MINT-4789742)|tag:?-?(MINT-4789746)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q80VP1	uniprotkb:Q9Z0R4	intact:EBI-7068702|ensembl:ENSMUSP00000043340|ensembl:ENSMUSP00000096445|uniprotkb:Q6NX78|uniprotkb:O70446|intact:MINT-4094555	intact:EBI-645386|uniprotkb:Q9R143|uniprotkb:F8VQE5|ensembl:ENSMUSP00000109635	psi-mi:epn1_mouse(display_long)|uniprotkb:Epn1(gene name)|psi-mi:Epn1(display_short)|uniprotkb:EPS-15-interacting protein 1(gene name synonym)|uniprotkb:Intersectin-EH-binding protein 1(gene name synonym)	psi-mi:itsn1_mouse(display_long)|uniprotkb:EH and SH3 domains protein 1(gene name synonym)|uniprotkb:Itsn1(gene name)|psi-mi:Itsn1(display_short)|uniprotkb:Ese1(gene name synonym)|uniprotkb:Itsn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Willard et al. (2007)	pubmed:17380122|imex:IM-11437|mint:MINT-5219791	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7340792|mint:MINT-4789804|imex:IM-11437-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006539592.2|refseq:XP_006539594.2|refseq:XP_006539596.1|refseq:XP_006539597.1|refseq:XP_006539598.1|refseq:XP_006539599.1|ensembl:ENSMUSG00000035203(gene)|ensembl:ENSMUST00000045277(transcript)|ensembl:ENSMUST00000098845(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0090148"(membrane fission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|mint:Q80VP1|reactome:R-MMU-182971|reactome:R-MMU-8856825|reactome:R-MMU-8856828|refseq:NP_034277.1|refseq:NP_001239383.1|dip:DIP-43943N|mint:MINT-4789805(identity)	refseq:NP_001103745.1|refseq:NP_034717.2|ensembl:ENSMUSG00000022957(gene)|ensembl:ENSMUST00000114002(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0019209"(kinase activator activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044305"(calyx of Held)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098833"(presynaptic endocytic zone)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q9Z0R4|rcsb pdb:3HS8|rcsb pdb:3JV3|reactome:R-MMU-193648|reactome:R-MMU-3928662|reactome:R-MMU-416482|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-9013148|reactome:R-MMU-9013406|reactome:R-MMU-9013408|mint:MINT-4789811(identity)	-	comment:mint|function:"Binds to membranes enriched in phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis"	-	figure legend:SF1A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2007/06/04	2014/10/16	rogid:M0Wyq39dW71X3O9oW8sRBZLvkuU10090	rogid:naFu4D6P1S+/t5+VVVeb0De8lEg10090	intact-crc:E0EC638CEA43FFE6|rigid:k51inRdCq+LqNRXifWaYG5fBMC4	false	tag:?-?(MINT-4789806)	binding-associated region:?-?(MINT-4789818)|tag:?-?(MINT-4789812)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O08774	uniprotkb:P04627	intact:EBI-7340877|intact:MINT-4582072|uniprotkb:O88383	intact:EBI-644485|uniprotkb:Q99J44|uniprotkb:Q9CTT5|uniprotkb:Q9D6R6|uniprotkb:Q9DBU7|uniprotkb:B1AUN9|ensembl:ENSMUSP00000001155	psi-mi:rgs12_rat(display_long)|uniprotkb:Rgs12(gene name)|psi-mi:Rgs12(display_short)	psi-mi:araf_mouse(display_long)|uniprotkb:Araf(gene name)|psi-mi:Araf(display_short)|uniprotkb:A-raf(gene name synonym)|uniprotkb:Araf1(gene name synonym)|uniprotkb:Proto-oncogene A-Raf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Willard et al. (2007)	pubmed:17380122|imex:IM-11437|mint:MINT-5219791	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7340923|mint:MINT-4789824|imex:IM-11437-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR037880|mint:O08774|rgd:3564|interpro:IPR016137(Regulator of G protein signalling superfamily)|refseq:NP_062212.1|interpro:IPR024066|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003109(GoLoco)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038032"(termination of G protein-coupled receptor signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0097440"(apical dendrite)|reactome:R-RNO-418594|interpro:IPR029071|interpro:IPR036034|interpro:IPR036305|mint:MINT-4789833(identity)	refseq:NP_001153117.1|refseq:NP_033833.1|ensembl:ENSMUSG00000001127(gene)|ensembl:ENSMUST00000001155(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04627|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5675221|refseq:XP_006527619.1|refseq:XP_006527620.1|dip:DIP-1070N|mint:MINT-4789825(identity)	-	function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form|comment:mint	-	figure legend:SF1B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2007/06/04	2014/10/16	rogid:3tbEsEuKxNo/Vja3i3Ai3Y61YsU10116	rogid:/0GyghXkkvb5pkn538YAgEqPepI10090	intact-crc:34A296B36C0152DB|rigid:ykNuyYlm0lhXuolzVes1k3AAym4	false	tag:?-?(MINT-4789834)|binding-associated region:702-1115(MINT-4789838)	tag:?-?(MINT-4789826)|binding-associated region:36-153(MINT-4789830)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8CGE9	uniprotkb:Q63932	intact:EBI-7340552|intact:MINT-4115792|uniprotkb:E9PXX2|ensembl:ENSMUSP00000030984	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	psi-mi:rgs12_mouse(display_long)|uniprotkb:Rgs12(gene name)|psi-mi:Rgs12(display_short)	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Willard et al. (2007)	pubmed:17380122|imex:IM-11437|mint:MINT-5219791	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7340995|mint:MINT-4789846|imex:IM-11437-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_775578.2|ensembl:ENSMUSG00000029101(gene)|ensembl:ENSMUST00000030984(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038032"(termination of G protein-coupled receptor signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0097440"(apical dendrite)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003109(GoLoco)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR036034|interpro:IPR036305|interpro:IPR037880|mint:Q8CGE9|reactome:R-MMU-418594|mint:MINT-4789855(identity)	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N|mint:MINT-4789847(identity)	-	comment:mint	-	figure legend:SF2|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/06/04	2014/10/16	rogid:py2jNyvxGHKC0cnn2YcrPpvXfd410090	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	intact-crc:691BBE6F612E510C|rigid:t/OJ8H2o8ro4lv3QRx6Y50g7xpQ	false	binding-associated region:1-98(MINT-4789860)|his tag:?-?(MINT-4789872)	mutation disrupting interaction:399-401(MINT-4789868)|binding-associated region:386-401(MINT-4789852)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8CGE9	uniprotkb:Q63932	intact:EBI-7340552|intact:MINT-4115792|uniprotkb:E9PXX2|ensembl:ENSMUSP00000030984	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	psi-mi:rgs12_mouse(display_long)|uniprotkb:Rgs12(gene name)|psi-mi:Rgs12(display_short)	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Willard et al. (2007)	pubmed:17380122|imex:IM-11437|mint:MINT-5219791	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7341324|mint:MINT-4789875|imex:IM-11437-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_775578.2|ensembl:ENSMUSG00000029101(gene)|ensembl:ENSMUST00000030984(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038032"(termination of G protein-coupled receptor signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0097440"(apical dendrite)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003109(GoLoco)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR036034|interpro:IPR036305|interpro:IPR037880|mint:Q8CGE9|reactome:R-MMU-418594|mint:MINT-4789876(identity)	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N|mint:MINT-4789883(identity)	-	comment:mint	-	figure legend:F1B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/06/04	2014/10/16	rogid:py2jNyvxGHKC0cnn2YcrPpvXfd410090	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	intact-crc:D59FCC37880BD5B9|rigid:t/OJ8H2o8ro4lv3QRx6Y50g7xpQ	false	ha tag:?-?(MINT-4789877)|binding-associated region:1-98(MINT-4789880)	flag tag:?-?(MINT-4789895)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P20171	uniprotkb:Q8CGE9	intact:EBI-7341402|uniprotkb:Q5RJJ8|uniprotkb:Q4KLL6|intact:MINT-4996514|ensembl:ENSRNOP00000022363|ensembl:ENSRNOP00000069770	intact:EBI-7340552|intact:MINT-4115792|uniprotkb:E9PXX2|ensembl:ENSMUSP00000030984	psi-mi:rash_rat(display_long)|uniprotkb:Hras(gene name)|psi-mi:Hras(display_short)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:Hras1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:p21ras(gene name synonym)	psi-mi:rgs12_mouse(display_long)|uniprotkb:Rgs12(gene name)|psi-mi:Rgs12(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Willard et al. (2007)	pubmed:17380122|imex:IM-11437|mint:MINT-5219791	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7341465|mint:MINT-4789947|imex:IM-11437-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001091711.1|rgd:2827|refseq:NP_001123913.1|ensembl:ENSRNOG00000016611(gene)|ensembl:ENSRNOT00000022363(transcript)|ensembl:ENSRNOT00000079464(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P20171|rcsb pdb:3V4F|reactome:R-RNO-1169092|reactome:R-RNO-1250347|reactome:R-RNO-1433557|reactome:R-RNO-171007|reactome:R-RNO-179812|reactome:R-RNO-180336|reactome:R-RNO-186763|reactome:R-RNO-1963640|reactome:R-RNO-210993|reactome:R-RNO-2179392|reactome:R-RNO-2424491|reactome:R-RNO-2871796|reactome:R-RNO-375165|reactome:R-RNO-3928662|reactome:R-RNO-5218921|reactome:R-RNO-5621575|reactome:R-RNO-5654688|reactome:R-RNO-5654693|reactome:R-RNO-5654699|reactome:R-RNO-5654700|reactome:R-RNO-5654704|reactome:R-RNO-5654706|reactome:R-RNO-5654712|reactome:R-RNO-5654719|reactome:R-RNO-5658442|reactome:R-RNO-5673000|reactome:R-RNO-5673001|reactome:R-RNO-5674135|reactome:R-RNO-5675221|reactome:R-RNO-8849471|reactome:R-RNO-8851805|reactome:R-RNO-9607240|go:"GO:0090314"(positive regulation of protein targeting to membrane)|reactome:R-RNO-9634635|reactome:R-RNO-9648002|mint:MINT-4789948(identity)	refseq:NP_775578.2|ensembl:ENSMUSG00000029101(gene)|ensembl:ENSMUST00000030984(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038032"(termination of G protein-coupled receptor signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0097440"(apical dendrite)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003109(GoLoco)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR036034|interpro:IPR036305|interpro:IPR037880|mint:Q8CGE9|reactome:R-MMU-418594|mint:MINT-4789954(identity)	-	function:Ras proteins bind GDP/GTP and possess intrinsic GTPase activity|comment:mint	comment:mint	figure legend:F2A|figure legend:F2B|figure legend:F2D|figure legend:F2C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/06/04	2014/10/16	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw10116	rogid:py2jNyvxGHKC0cnn2YcrPpvXfd410090	intact-crc:FAC723CFA9BE9F3E|rigid:ksAlw3LzihXufx1e96lC7F/dDqA	false	mutation increasing interaction:12-12(MINT-4789963)|ha tag:?-?(MINT-4789951)	myc tag:?-?(MINT-4789960)|mutation decreasing interaction:995-995(MINT-4789967)|binding-associated region:966-1102(MINT-4789955)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8CGE9	uniprotkb:Q04970	intact:EBI-7340552|intact:MINT-4115792|uniprotkb:E9PXX2|ensembl:ENSMUSP00000030984	intact:EBI-7341579|intact:MINT-4789999|uniprotkb:Q4KMB1|ensembl:ENSRNOP00000036381	psi-mi:rgs12_mouse(display_long)|uniprotkb:Rgs12(gene name)|psi-mi:Rgs12(display_short)	psi-mi:rasn_rat(display_long)|uniprotkb:Nras(gene name)|psi-mi:Nras(display_short)|uniprotkb:Transforming protein N-Ras(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Willard et al. (2007)	pubmed:17380122|imex:IM-11437|mint:MINT-5219791	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7341613|mint:MINT-4789974|imex:IM-11437-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_775578.2|ensembl:ENSMUSG00000029101(gene)|ensembl:ENSMUST00000030984(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038032"(termination of G protein-coupled receptor signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0097440"(apical dendrite)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003109(GoLoco)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR036034|interpro:IPR036305|interpro:IPR037880|mint:Q8CGE9|reactome:R-MMU-418594|mint:MINT-4789984(identity)	rgd:3205|refseq:NP_542944.1|ensembl:ENSRNOG00000023079(gene)|ensembl:ENSRNOT00000039572(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:Q04970|reactome:R-RNO-1169092|reactome:R-RNO-1250347|reactome:R-RNO-1433557|reactome:R-RNO-171007|reactome:R-RNO-179812|reactome:R-RNO-180336|reactome:R-RNO-186763|reactome:R-RNO-1963640|reactome:R-RNO-210993|reactome:R-RNO-2179392|reactome:R-RNO-2424491|reactome:R-RNO-2871796|reactome:R-RNO-375165|reactome:R-RNO-5218921|reactome:R-RNO-5621575|reactome:R-RNO-5654688|reactome:R-RNO-5654693|reactome:R-RNO-5654699|reactome:R-RNO-5654700|reactome:R-RNO-5654704|reactome:R-RNO-5654706|reactome:R-RNO-5654712|reactome:R-RNO-5654719|reactome:R-RNO-5658442|reactome:R-RNO-5673000|reactome:R-RNO-5673001|reactome:R-RNO-5674135|reactome:R-RNO-5675221|reactome:R-RNO-6798695|reactome:R-RNO-8849471|reactome:R-RNO-8851805|reactome:R-RNO-9607240|reactome:R-RNO-9634635|reactome:R-RNO-9648002|refseq:XP_006233121.1|mint:MINT-4789975(identity)	-	comment:mint	function:Ras proteins bind GDP/GTP and possess intrinsic GTPase activity|comment:mint	figure legend:F2A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/06/04	2014/10/16	rogid:py2jNyvxGHKC0cnn2YcrPpvXfd410090	rogid:6IDUmyT2Z4p3n+K4aE81a1brDl010116	intact-crc:3C05007F06024BEC|rigid:n/L7CWNjM6KQp8Z/aWkBAPosr1Y	false	mutation decreasing interaction:995-995(MINT-4789985)|binding-associated region:966-1102(MINT-4789992)|myc tag:?-?(MINT-4789988)	mutation increasing interaction:12-12(MINT-4789976)|ha tag:?-?(MINT-4789979)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8CGE9	uniprotkb:P15056	intact:EBI-7340552|intact:MINT-4115792|uniprotkb:E9PXX2|ensembl:ENSMUSP00000030984	intact:EBI-365980|uniprotkb:Q13878|uniprotkb:Q3MIN6|intact:EBI-28988924|ensembl:ENSP00000493543|uniprotkb:Q9UDP8|uniprotkb:Q9Y6T3|uniprotkb:A4D1T4|uniprotkb:B6HY61|uniprotkb:B6HY62|uniprotkb:B6HY63|uniprotkb:B6HY64|uniprotkb:B6HY65|uniprotkb:B6HY66	psi-mi:rgs12_mouse(display_long)|uniprotkb:Rgs12(gene name)|psi-mi:Rgs12(display_short)	psi-mi:braf_human(display_long)|uniprotkb:BRAF(gene name)|psi-mi:BRAF(display_short)|uniprotkb:BRAF1(gene name synonym)|uniprotkb:RAFB1(gene name synonym)|uniprotkb:v-Raf murine sarcoma viral oncogene homolog B1(gene name synonym)|uniprotkb:p94(gene name synonym)|uniprotkb:Proto-oncogene B-Raf(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Willard et al. (2007)	pubmed:17380122|imex:IM-11437|mint:MINT-5219791	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7341703|mint:MINT-4790050|imex:IM-11437-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_775578.2|ensembl:ENSMUSG00000029101(gene)|ensembl:ENSMUST00000030984(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038032"(termination of G protein-coupled receptor signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0097440"(apical dendrite)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003109(GoLoco)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR036034|interpro:IPR036305|interpro:IPR037880|mint:Q8CGE9|reactome:R-MMU-418594|mint:MINT-4790057(identity)	ensembl:ENSG00000157764(gene)|ensembl:ENST00000646891(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|go:"GO:0042802"(identical protein binding)|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-1295596|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-187706|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|rcsb pdb:4FK3|rcsb pdb:4G9C|rcsb pdb:4G9R|rcsb pdb:4H58|rcsb pdb:4JVG|rcsb pdb:4KSP|rcsb pdb:4KSQ|rcsb pdb:4FC0|rcsb pdb:4MBJ|rcsb pdb:4MNE|rcsb pdb:4MNF|rcsb pdb:4PP7|rcsb pdb:4R5Y|rcsb pdb:4RZV|rcsb pdb:4RZW|rcsb pdb:4WO5|rcsb pdb:4XV1|rcsb pdb:4XV2|rcsb pdb:4XV3|rcsb pdb:4XV9|rcsb pdb:4YHT|rcsb pdb:5C9C|rcsb pdb:5CSW|rcsb pdb:5CSX|rcsb pdb:5CT7|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070413"(trehalose metabolism in response to stress)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|rcsb pdb:5FD2|rcsb pdb:5HI2|rcsb pdb:5HID|rcsb pdb:5HIE|rcsb pdb:5ITA|rcsb pdb:5J17|rcsb pdb:5J18|rcsb pdb:5J2R|rcsb pdb:5JRQ|rcsb pdb:5JSM|rcsb pdb:5JT2|rcsb pdb:5VAL|rcsb pdb:5VAM|rcsb pdb:5VR3|rcsb pdb:5VYK|rcsb pdb:6B8U|rcsb pdb:6CAD|rcsb pdb:6N0P|rcsb pdb:6N0Q|rcsb pdb:6NSQ|rcsb pdb:6NYB|rcsb pdb:6P3D|rcsb pdb:6P7G|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0K|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6U2H|rcsb pdb:6UAN|rcsb pdb:6UUO|rcsb pdb:6V2U|rcsb pdb:6V2W|rcsb pdb:6XAG|mint:P15056|rcsb pdb:1UWH|rcsb pdb:1UWJ|rcsb pdb:2FB8|rcsb pdb:2L05|rcsb pdb:3C4C|interpro:IPR029071|rcsb pdb:3D4Q|rcsb pdb:3IDP|rcsb pdb:3II5|rcsb pdb:3NY5|rcsb pdb:3OG7|rcsb pdb:3PPJ|rcsb pdb:3PPK|rcsb pdb:3PRF|rcsb pdb:3PRI|rcsb pdb:3PSB|rcsb pdb:3PSD|rcsb pdb:3Q4C|rcsb pdb:3Q96|rcsb pdb:3SKC|rcsb pdb:3TV4|rcsb pdb:3TV6|rcsb pdb:4CQE|rcsb pdb:4DBN|rcsb pdb:4E26|rcsb pdb:4E4X|rcsb pdb:4EHE|rcsb pdb:4EHG|refseq:NP_004324.2|ensembl:ENSP00000493543|dip:DIP-1045N|mint:MINT-4790051(identity)	-	comment:mint	-	figure legend:SF4|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/06/04	2014/10/16	rogid:py2jNyvxGHKC0cnn2YcrPpvXfd410090	rogid:sfzILpNpX8UFB/vgH9LOKLpl/+g9606	intact-crc:7FB473B25917D0C6|rigid:Ywx7hUQyJ+xNJfjXbmYaVhcgWxk	false	myc tag:?-?(MINT-4790063)	binding-associated region:1-374(MINT-4790073)|flag tag:?-?(MINT-4790054)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8CGE9	uniprotkb:P04627	intact:EBI-7340552|intact:MINT-4115792|uniprotkb:E9PXX2|ensembl:ENSMUSP00000030984	intact:EBI-644485|uniprotkb:Q99J44|uniprotkb:Q9CTT5|uniprotkb:Q9D6R6|uniprotkb:Q9DBU7|uniprotkb:B1AUN9|ensembl:ENSMUSP00000001155	psi-mi:rgs12_mouse(display_long)|uniprotkb:Rgs12(gene name)|psi-mi:Rgs12(display_short)	psi-mi:araf_mouse(display_long)|uniprotkb:Araf(gene name)|psi-mi:Araf(display_short)|uniprotkb:A-raf(gene name synonym)|uniprotkb:Araf1(gene name synonym)|uniprotkb:Proto-oncogene A-Raf(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Willard et al. (2007)	pubmed:17380122|imex:IM-11437|mint:MINT-5219791	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7341792|mint:MINT-4789901|imex:IM-11437-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_775578.2|ensembl:ENSMUSG00000029101(gene)|ensembl:ENSMUST00000030984(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038032"(termination of G protein-coupled receptor signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0097440"(apical dendrite)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003109(GoLoco)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR036034|interpro:IPR036305|interpro:IPR037880|mint:Q8CGE9|reactome:R-MMU-418594|mint:MINT-4789902(identity)	refseq:NP_001153117.1|refseq:NP_033833.1|ensembl:ENSMUSG00000001127(gene)|ensembl:ENSMUST00000001155(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04627|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5675221|refseq:XP_006527619.1|refseq:XP_006527620.1|dip:DIP-1070N|mint:MINT-4789910(identity)	-	comment:mint	-	figure legend:F1C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2007/06/04	2014/10/16	rogid:py2jNyvxGHKC0cnn2YcrPpvXfd410090	rogid:/0GyghXkkvb5pkn538YAgEqPepI10090	intact-crc:FDD58B37FE77A2CB|rigid:oJQ0ydk8LNJHsm/D5U6Fb9G4/Kk	false	myc tag:?-?(MINT-4789903)	ha tag:?-?(MINT-4789913)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8CGE9	uniprotkb:P15056	intact:EBI-7340552|intact:MINT-4115792|uniprotkb:E9PXX2|ensembl:ENSMUSP00000030984	intact:EBI-365980|uniprotkb:Q13878|uniprotkb:Q3MIN6|intact:EBI-28988924|ensembl:ENSP00000493543|uniprotkb:Q9UDP8|uniprotkb:Q9Y6T3|uniprotkb:A4D1T4|uniprotkb:B6HY61|uniprotkb:B6HY62|uniprotkb:B6HY63|uniprotkb:B6HY64|uniprotkb:B6HY65|uniprotkb:B6HY66	psi-mi:rgs12_mouse(display_long)|uniprotkb:Rgs12(gene name)|psi-mi:Rgs12(display_short)	psi-mi:braf_human(display_long)|uniprotkb:BRAF(gene name)|psi-mi:BRAF(display_short)|uniprotkb:BRAF1(gene name synonym)|uniprotkb:RAFB1(gene name synonym)|uniprotkb:v-Raf murine sarcoma viral oncogene homolog B1(gene name synonym)|uniprotkb:p94(gene name synonym)|uniprotkb:Proto-oncogene B-Raf(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Willard et al. (2007)	pubmed:17380122|imex:IM-11437|mint:MINT-5219791	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7341830|mint:MINT-4789922|imex:IM-11437-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_775578.2|ensembl:ENSMUSG00000029101(gene)|ensembl:ENSMUST00000030984(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038032"(termination of G protein-coupled receptor signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0097440"(apical dendrite)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003109(GoLoco)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR036034|interpro:IPR036305|interpro:IPR037880|mint:Q8CGE9|reactome:R-MMU-418594|mint:MINT-4789923(identity)	ensembl:ENSG00000157764(gene)|ensembl:ENST00000646891(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|go:"GO:0042802"(identical protein binding)|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-1295596|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-187706|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|rcsb pdb:4FK3|rcsb pdb:4G9C|rcsb pdb:4G9R|rcsb pdb:4H58|rcsb pdb:4JVG|rcsb pdb:4KSP|rcsb pdb:4KSQ|rcsb pdb:4FC0|rcsb pdb:4MBJ|rcsb pdb:4MNE|rcsb pdb:4MNF|rcsb pdb:4PP7|rcsb pdb:4R5Y|rcsb pdb:4RZV|rcsb pdb:4RZW|rcsb pdb:4WO5|rcsb pdb:4XV1|rcsb pdb:4XV2|rcsb pdb:4XV3|rcsb pdb:4XV9|rcsb pdb:4YHT|rcsb pdb:5C9C|rcsb pdb:5CSW|rcsb pdb:5CSX|rcsb pdb:5CT7|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070413"(trehalose metabolism in response to stress)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|rcsb pdb:5FD2|rcsb pdb:5HI2|rcsb pdb:5HID|rcsb pdb:5HIE|rcsb pdb:5ITA|rcsb pdb:5J17|rcsb pdb:5J18|rcsb pdb:5J2R|rcsb pdb:5JRQ|rcsb pdb:5JSM|rcsb pdb:5JT2|rcsb pdb:5VAL|rcsb pdb:5VAM|rcsb pdb:5VR3|rcsb pdb:5VYK|rcsb pdb:6B8U|rcsb pdb:6CAD|rcsb pdb:6N0P|rcsb pdb:6N0Q|rcsb pdb:6NSQ|rcsb pdb:6NYB|rcsb pdb:6P3D|rcsb pdb:6P7G|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0K|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6U2H|rcsb pdb:6UAN|rcsb pdb:6UUO|rcsb pdb:6V2U|rcsb pdb:6V2W|rcsb pdb:6XAG|mint:P15056|rcsb pdb:1UWH|rcsb pdb:1UWJ|rcsb pdb:2FB8|rcsb pdb:2L05|rcsb pdb:3C4C|interpro:IPR029071|rcsb pdb:3D4Q|rcsb pdb:3IDP|rcsb pdb:3II5|rcsb pdb:3NY5|rcsb pdb:3OG7|rcsb pdb:3PPJ|rcsb pdb:3PPK|rcsb pdb:3PRF|rcsb pdb:3PRI|rcsb pdb:3PSB|rcsb pdb:3PSD|rcsb pdb:3Q4C|rcsb pdb:3Q96|rcsb pdb:3SKC|rcsb pdb:3TV4|rcsb pdb:3TV6|rcsb pdb:4CQE|rcsb pdb:4DBN|rcsb pdb:4E26|rcsb pdb:4E4X|rcsb pdb:4EHE|rcsb pdb:4EHG|refseq:NP_004324.2|ensembl:ENSP00000493543|dip:DIP-1045N|mint:MINT-4789928(identity)	-	comment:mint	-	figure legend:F1D|figure legend:F2E|comment:Interaction also occurs in Hek293T cells.|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2007/06/04	2014/10/16	rogid:py2jNyvxGHKC0cnn2YcrPpvXfd410090	rogid:sfzILpNpX8UFB/vgH9LOKLpl/+g9606	intact-crc:A7ECF54EC33972CF|rigid:Ywx7hUQyJ+xNJfjXbmYaVhcgWxk	false	binding-associated region:966-1102(MINT-4789938)|myc tag:?-?(MINT-4789924)	ha tag:?-?(MINT-4789929)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O08774	uniprotkb:Q04970	intact:EBI-7340877|intact:MINT-4582072|uniprotkb:O88383	intact:EBI-7341579|intact:MINT-4789999|uniprotkb:Q4KMB1|ensembl:ENSRNOP00000036381	psi-mi:rgs12_rat(display_long)|uniprotkb:Rgs12(gene name)|psi-mi:Rgs12(display_short)	psi-mi:rasn_rat(display_long)|uniprotkb:Nras(gene name)|psi-mi:Nras(display_short)|uniprotkb:Transforming protein N-Ras(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Willard et al. (2007)	pubmed:17380122|imex:IM-11437|mint:MINT-5219791	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7341921|mint:MINT-4790013|imex:IM-11437-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR037880|mint:O08774|rgd:3564|interpro:IPR016137(Regulator of G protein signalling superfamily)|refseq:NP_062212.1|interpro:IPR024066|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003109(GoLoco)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038032"(termination of G protein-coupled receptor signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0097440"(apical dendrite)|reactome:R-RNO-418594|interpro:IPR029071|interpro:IPR036034|interpro:IPR036305|mint:MINT-4790023(identity)	rgd:3205|refseq:NP_542944.1|ensembl:ENSRNOG00000023079(gene)|ensembl:ENSRNOT00000039572(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:Q04970|reactome:R-RNO-1169092|reactome:R-RNO-1250347|reactome:R-RNO-1433557|reactome:R-RNO-171007|reactome:R-RNO-179812|reactome:R-RNO-180336|reactome:R-RNO-186763|reactome:R-RNO-1963640|reactome:R-RNO-210993|reactome:R-RNO-2179392|reactome:R-RNO-2424491|reactome:R-RNO-2871796|reactome:R-RNO-375165|reactome:R-RNO-5218921|reactome:R-RNO-5621575|reactome:R-RNO-5654688|reactome:R-RNO-5654693|reactome:R-RNO-5654699|reactome:R-RNO-5654700|reactome:R-RNO-5654704|reactome:R-RNO-5654706|reactome:R-RNO-5654712|reactome:R-RNO-5654719|reactome:R-RNO-5658442|reactome:R-RNO-5673000|reactome:R-RNO-5673001|reactome:R-RNO-5674135|reactome:R-RNO-5675221|reactome:R-RNO-6798695|reactome:R-RNO-8849471|reactome:R-RNO-8851805|reactome:R-RNO-9607240|reactome:R-RNO-9634635|reactome:R-RNO-9648002|refseq:XP_006233121.1|mint:MINT-4790014(identity)	-	function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form|comment:mint	function:Ras proteins bind GDP/GTP and possess intrinsic GTPase activity|comment:mint	figure legend:F4A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2007/06/04	2014/10/16	rogid:3tbEsEuKxNo/Vja3i3Ai3Y61YsU10116	rogid:6IDUmyT2Z4p3n+K4aE81a1brDl010116	intact-crc:022F49F6B66E1B63|rigid:p1iI0CGm+++kisnxhDszIwd9Igw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O08774	uniprotkb:P15056	intact:EBI-7340877|intact:MINT-4582072|uniprotkb:O88383	intact:EBI-365980|uniprotkb:Q13878|uniprotkb:Q3MIN6|intact:EBI-28988924|ensembl:ENSP00000493543|uniprotkb:Q9UDP8|uniprotkb:Q9Y6T3|uniprotkb:A4D1T4|uniprotkb:B6HY61|uniprotkb:B6HY62|uniprotkb:B6HY63|uniprotkb:B6HY64|uniprotkb:B6HY65|uniprotkb:B6HY66	psi-mi:rgs12_rat(display_long)|uniprotkb:Rgs12(gene name)|psi-mi:Rgs12(display_short)	psi-mi:braf_human(display_long)|uniprotkb:BRAF(gene name)|psi-mi:BRAF(display_short)|uniprotkb:BRAF1(gene name synonym)|uniprotkb:RAFB1(gene name synonym)|uniprotkb:v-Raf murine sarcoma viral oncogene homolog B1(gene name synonym)|uniprotkb:p94(gene name synonym)|uniprotkb:Proto-oncogene B-Raf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Willard et al. (2007)	pubmed:17380122|imex:IM-11437|mint:MINT-5219791	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7341965|mint:MINT-4790040|imex:IM-11437-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR037880|mint:O08774|rgd:3564|interpro:IPR016137(Regulator of G protein signalling superfamily)|refseq:NP_062212.1|interpro:IPR024066|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003109(GoLoco)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038032"(termination of G protein-coupled receptor signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0097440"(apical dendrite)|reactome:R-RNO-418594|interpro:IPR029071|interpro:IPR036034|interpro:IPR036305|mint:MINT-4790041(identity)	ensembl:ENSG00000157764(gene)|ensembl:ENST00000646891(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|go:"GO:0042802"(identical protein binding)|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-1295596|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-187706|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|rcsb pdb:4FK3|rcsb pdb:4G9C|rcsb pdb:4G9R|rcsb pdb:4H58|rcsb pdb:4JVG|rcsb pdb:4KSP|rcsb pdb:4KSQ|rcsb pdb:4FC0|rcsb pdb:4MBJ|rcsb pdb:4MNE|rcsb pdb:4MNF|rcsb pdb:4PP7|rcsb pdb:4R5Y|rcsb pdb:4RZV|rcsb pdb:4RZW|rcsb pdb:4WO5|rcsb pdb:4XV1|rcsb pdb:4XV2|rcsb pdb:4XV3|rcsb pdb:4XV9|rcsb pdb:4YHT|rcsb pdb:5C9C|rcsb pdb:5CSW|rcsb pdb:5CSX|rcsb pdb:5CT7|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070413"(trehalose metabolism in response to stress)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|rcsb pdb:5FD2|rcsb pdb:5HI2|rcsb pdb:5HID|rcsb pdb:5HIE|rcsb pdb:5ITA|rcsb pdb:5J17|rcsb pdb:5J18|rcsb pdb:5J2R|rcsb pdb:5JRQ|rcsb pdb:5JSM|rcsb pdb:5JT2|rcsb pdb:5VAL|rcsb pdb:5VAM|rcsb pdb:5VR3|rcsb pdb:5VYK|rcsb pdb:6B8U|rcsb pdb:6CAD|rcsb pdb:6N0P|rcsb pdb:6N0Q|rcsb pdb:6NSQ|rcsb pdb:6NYB|rcsb pdb:6P3D|rcsb pdb:6P7G|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0K|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6U2H|rcsb pdb:6UAN|rcsb pdb:6UUO|rcsb pdb:6V2U|rcsb pdb:6V2W|rcsb pdb:6XAG|mint:P15056|rcsb pdb:1UWH|rcsb pdb:1UWJ|rcsb pdb:2FB8|rcsb pdb:2L05|rcsb pdb:3C4C|interpro:IPR029071|rcsb pdb:3D4Q|rcsb pdb:3IDP|rcsb pdb:3II5|rcsb pdb:3NY5|rcsb pdb:3OG7|rcsb pdb:3PPJ|rcsb pdb:3PPK|rcsb pdb:3PRF|rcsb pdb:3PRI|rcsb pdb:3PSB|rcsb pdb:3PSD|rcsb pdb:3Q4C|rcsb pdb:3Q96|rcsb pdb:3SKC|rcsb pdb:3TV4|rcsb pdb:3TV6|rcsb pdb:4CQE|rcsb pdb:4DBN|rcsb pdb:4E26|rcsb pdb:4E4X|rcsb pdb:4EHE|rcsb pdb:4EHG|refseq:NP_004324.2|ensembl:ENSP00000493543|dip:DIP-1045N|mint:MINT-4790044(identity)	-	function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form|comment:mint	-	figure legend:F4A|comment:Human B-Raf prot_id was used instead of the rat one.|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2007/06/04	2014/10/16	rogid:3tbEsEuKxNo/Vja3i3Ai3Y61YsU10116	rogid:sfzILpNpX8UFB/vgH9LOKLpl/+g9606	intact-crc:5325DF85EEA9C729|rigid:ts5vQ40k2268YjOv4AId57HH+hA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)