#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P61763 uniprotkb:P32850 intact:EBI-7335973|intact:MINT-4545076|uniprotkb:Q64320|uniprotkb:Q96TG8|uniprotkb:Q28208|uniprotkb:Q62759|ensembl:ENSBTAP00000004589 intact:EBI-7336000|intact:MINT-1214927|ensembl:ENSBTAP00000064870 psi-mi:stxb1_bovin(display_long)|uniprotkb:STXBP1(gene name)|psi-mi:STXBP1(display_short)|uniprotkb:UNC18A(gene name synonym)|uniprotkb:N-Sec1(gene name synonym)|uniprotkb:p67(gene name synonym)|uniprotkb:Protein unc-18 homolog 1(gene name synonym)|uniprotkb:Protein unc-18 homolog A(gene name synonym) psi-mi:stx1a_bovin(display_long)|uniprotkb:STX1A(gene name)|psi-mi:STX1A(display_short)|uniprotkb:Synaptotagmin-associated 35 kDa protein(gene name synonym)|uniprotkb:Neuron-specific antigen HPC-1(gene name synonym) psi-mi:"MI:0096"(pull down) Connell et al. (2007) pubmed:17363971|imex:IM-10861|mint:MINT-5219782 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7336024|mint:MINT-4545096|imex:IM-10861-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_777044.1|ensembl:ENSBTAG00000003525(gene)|ensembl:ENSBTAT00000004589(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007412"(axon target recognition)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0098793"(presynapse)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|mint:P61763|mint:MINT-4545097(identity) refseq:XP_005225301.1|ensembl:ENSBTAG00000017075(gene)|ensembl:ENSBTAT00000084274(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0043005"(neuron projection)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048278"(vesicle docking)|go:"GO:0048787"(presynaptic active zone membrane)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028669|mint:P32850|mint:MINT-4545098(identity) - comment:mint|function:"May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions" comment:mint|function:Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis figure legend:F3A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/04/26 2014/10/16 rogid:yUYi89hDkfMdQ1BdH52swZQFCLk9913 rogid:dqHojUrfJV598kiWyqciw2UsqKo9913 intact-crc:29A9B82E341886A5|rigid:y7FaqgqzsE+fphDrID/fvAnihG4 false - glutathione s tranferase tag:?-?(MINT-4545102) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P61763 uniprotkb:Q13277 intact:EBI-7335973|intact:MINT-4545076|uniprotkb:Q64320|uniprotkb:Q96TG8|uniprotkb:Q28208|uniprotkb:Q62759|ensembl:ENSBTAP00000004589 intact:EBI-1394295|uniprotkb:O43750|uniprotkb:O43751|uniprotkb:Q15360|uniprotkb:B4DME0|ensembl:ENSP00000338562 psi-mi:stxb1_bovin(display_long)|uniprotkb:STXBP1(gene name)|psi-mi:STXBP1(display_short)|uniprotkb:UNC18A(gene name synonym)|uniprotkb:N-Sec1(gene name synonym)|uniprotkb:p67(gene name synonym)|uniprotkb:Protein unc-18 homolog 1(gene name synonym)|uniprotkb:Protein unc-18 homolog A(gene name synonym) psi-mi:stx3_human(display_long)|uniprotkb:STX3(gene name)|psi-mi:STX3(display_short)|uniprotkb:STX3A(gene name synonym) psi-mi:"MI:0096"(pull down) Connell et al. (2007) pubmed:17363971|imex:IM-10861|mint:MINT-5219782 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7336054|mint:MINT-4545212|imex:IM-10861-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_777044.1|ensembl:ENSBTAG00000003525(gene)|ensembl:ENSBTAT00000004589(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007412"(axon target recognition)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0098793"(presynapse)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|mint:P61763|mint:MINT-4545213(identity) refseq:NP_004168.1|refseq:NP_001171511.1|refseq:XP_005274252.1|refseq:XP_005274257.1|ensembl:ENSG00000166900(gene)|ensembl:ENST00000337979(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042581"(specific granule)|go:"GO:0042582"(azurophil granule)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048278"(vesicle docking)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050544"(arachidonic acid binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR031186|mint:Q13277|reactome:R-HSA-449836|mint:MINT-4545217(identity) - comment:mint|function:"May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions" - figure legend:F4A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/04/26 2014/10/16 rogid:yUYi89hDkfMdQ1BdH52swZQFCLk9913 rogid:M/ue1L+l8LnUJNpEWVZ/KWR5UjM9606 intact-crc:5A2D6BDAE3DEE152|rigid:7My7iU/jik4MR+z0HWVwW7vkKP4 false - glutathione s tranferase tag:?-?(MINT-4545219) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P32850 uniprotkb:P61763 intact:EBI-7336000|intact:MINT-1214927|ensembl:ENSBTAP00000064870 intact:EBI-7335973|intact:MINT-4545076|uniprotkb:Q64320|uniprotkb:Q96TG8|uniprotkb:Q28208|uniprotkb:Q62759|ensembl:ENSBTAP00000004589 psi-mi:stx1a_bovin(display_long)|uniprotkb:STX1A(gene name)|psi-mi:STX1A(display_short)|uniprotkb:Synaptotagmin-associated 35 kDa protein(gene name synonym)|uniprotkb:Neuron-specific antigen HPC-1(gene name synonym) psi-mi:stxb1_bovin(display_long)|uniprotkb:STXBP1(gene name)|psi-mi:STXBP1(display_short)|uniprotkb:UNC18A(gene name synonym)|uniprotkb:N-Sec1(gene name synonym)|uniprotkb:p67(gene name synonym)|uniprotkb:Protein unc-18 homolog 1(gene name synonym)|uniprotkb:Protein unc-18 homolog A(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Connell et al. (2007) pubmed:17363971|imex:IM-10861|mint:MINT-5219782 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7336135|mint:MINT-4545144|imex:IM-10861-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005225301.1|ensembl:ENSBTAG00000017075(gene)|ensembl:ENSBTAT00000084274(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0043005"(neuron projection)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048278"(vesicle docking)|go:"GO:0048787"(presynaptic active zone membrane)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028669|mint:P32850|mint:MINT-4545148(identity) refseq:NP_777044.1|ensembl:ENSBTAG00000003525(gene)|ensembl:ENSBTAT00000004589(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007412"(axon target recognition)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0098793"(presynapse)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|mint:P61763|mint:MINT-4545145(identity) - comment:mint|function:Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis comment:mint|function:"May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions" figure legend:F3D|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/04/26 2014/10/16 rogid:dqHojUrfJV598kiWyqciw2UsqKo9913 rogid:yUYi89hDkfMdQ1BdH52swZQFCLk9913 intact-crc:B7F157F165071480|rigid:y7FaqgqzsE+fphDrID/fvAnihG4 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q17QQ3 uniprotkb:P61763 intact:EBI-7336080|intact:MINT-4545122|ensembl:ENSBTAP00000010961 intact:EBI-7335973|intact:MINT-4545076|uniprotkb:Q64320|uniprotkb:Q96TG8|uniprotkb:Q28208|uniprotkb:Q62759|ensembl:ENSBTAP00000004589 psi-mi:snp25_bovin(display_long)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym) psi-mi:stxb1_bovin(display_long)|uniprotkb:STXBP1(gene name)|psi-mi:STXBP1(display_short)|uniprotkb:UNC18A(gene name synonym)|uniprotkb:N-Sec1(gene name synonym)|uniprotkb:p67(gene name synonym)|uniprotkb:Protein unc-18 homolog 1(gene name synonym)|uniprotkb:Protein unc-18 homolog A(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Connell et al. (2007) pubmed:17363971|imex:IM-10861|mint:MINT-5219782 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7336122|mint:MINT-4545111|imex:IM-10861-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001069714.1|ensembl:ENSBTAG00000008323(gene)|ensembl:ENSBTAT00000010961(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:Q17QQ3|mint:MINT-4545116(identity) refseq:NP_777044.1|ensembl:ENSBTAG00000003525(gene)|ensembl:ENSBTAT00000004589(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007412"(axon target recognition)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0098793"(presynapse)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|mint:P61763|mint:MINT-4545112(identity) - comment:mint comment:mint|function:"May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions" figure legend:F3D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/04/26 2014/10/16 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9913 rogid:yUYi89hDkfMdQ1BdH52swZQFCLk9913 intact-crc:8E2A3C9A798E4836|rigid:d15lDx1t8ApMhSKlwqSik4MCKXw false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q17QQ3 uniprotkb:P32850 intact:EBI-7336080|intact:MINT-4545122|ensembl:ENSBTAP00000010961 intact:EBI-7336000|intact:MINT-1214927|ensembl:ENSBTAP00000064870 psi-mi:snp25_bovin(display_long)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym) psi-mi:stx1a_bovin(display_long)|uniprotkb:STX1A(gene name)|psi-mi:STX1A(display_short)|uniprotkb:Synaptotagmin-associated 35 kDa protein(gene name synonym)|uniprotkb:Neuron-specific antigen HPC-1(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Connell et al. (2007) pubmed:17363971|imex:IM-10861|mint:MINT-5219782 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7336175|mint:MINT-4545166|imex:IM-10861-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001069714.1|ensembl:ENSBTAG00000008323(gene)|ensembl:ENSBTAT00000010961(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:Q17QQ3|mint:MINT-4545171(identity) refseq:XP_005225301.1|ensembl:ENSBTAG00000017075(gene)|ensembl:ENSBTAT00000084274(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0043005"(neuron projection)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048278"(vesicle docking)|go:"GO:0048787"(presynaptic active zone membrane)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028669|mint:P32850|mint:MINT-4545167(identity) - comment:mint comment:mint|function:Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis figure legend:F3D|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/04/26 2014/10/16 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9913 rogid:dqHojUrfJV598kiWyqciw2UsqKo9913 intact-crc:2CB2B1C875D05578|rigid:388TfnoWVFw4tIpjJ2n/JCfnQ/8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P48018 uniprotkb:Q17QQ3 intact:EBI-7336194|intact:MINT-1214882|ensembl:ENSBTAP00000065714 intact:EBI-7336080|intact:MINT-4545122|ensembl:ENSBTAP00000010961 psi-mi:syt1_bovin(display_long)|uniprotkb:SYT1(gene name)|psi-mi:SYT1(display_short)|uniprotkb:Synaptotagmin I(gene name synonym)|uniprotkb:p65(gene name synonym) psi-mi:snp25_bovin(display_long)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Connell et al. (2007) pubmed:17363971|imex:IM-10861|mint:MINT-5219782 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7336187|mint:MINT-4545176|imex:IM-10861-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_776617.1|refseq:XP_005206087.1|ensembl:ENSBTAG00000034693(gene)|ensembl:ENSBTAT00000072222(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030276"(clathrin binding)|go:"GO:0031045"(dense core granule)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1903235"(positive regulation of calcium ion-dependent exocytosis of neurotransmitter)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|mint:P48018|mint:MINT-4545177(identity) refseq:NP_001069714.1|ensembl:ENSBTAG00000008323(gene)|ensembl:ENSBTAT00000010961(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:Q17QQ3|mint:MINT-4545181(identity) - comment:mint|function:"May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2" comment:mint figure legend:F3D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/04/26 2014/10/16 rogid:TAAVO0VVIdS86Of+Pc/HTnHQnp49913 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9913 intact-crc:EE3614C459D3252F|rigid:tLEEzImfvVzrU9qDC4YRtjTzldo false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q17QQ3 uniprotkb:P61763 intact:EBI-7336080|intact:MINT-4545122|ensembl:ENSBTAP00000010961 intact:EBI-7335973|intact:MINT-4545076|uniprotkb:Q64320|uniprotkb:Q96TG8|uniprotkb:Q28208|uniprotkb:Q62759|ensembl:ENSBTAP00000004589 psi-mi:snp25_bovin(display_long)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym) psi-mi:stxb1_bovin(display_long)|uniprotkb:STXBP1(gene name)|psi-mi:STXBP1(display_short)|uniprotkb:UNC18A(gene name synonym)|uniprotkb:N-Sec1(gene name synonym)|uniprotkb:p67(gene name synonym)|uniprotkb:Protein unc-18 homolog 1(gene name synonym)|uniprotkb:Protein unc-18 homolog A(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Connell et al. (2007) pubmed:17363971|imex:IM-10861|mint:MINT-5219782 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7336162|mint:MINT-4545154|imex:IM-10861-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001069714.1|ensembl:ENSBTAG00000008323(gene)|ensembl:ENSBTAT00000010961(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:Q17QQ3|mint:MINT-4545158(identity) refseq:NP_777044.1|ensembl:ENSBTAG00000003525(gene)|ensembl:ENSBTAT00000004589(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007412"(axon target recognition)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0098793"(presynapse)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|mint:P61763|mint:MINT-4545155(identity) - comment:mint comment:mint|function:"May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions" figure legend:F3D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/04/26 2014/10/16 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9913 rogid:yUYi89hDkfMdQ1BdH52swZQFCLk9913 intact-crc:32AE2FE3F1954083|rigid:d15lDx1t8ApMhSKlwqSik4MCKXw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q17QQ3 uniprotkb:P61763 intact:EBI-7336080|intact:MINT-4545122|ensembl:ENSBTAP00000010961 intact:EBI-7335973|intact:MINT-4545076|uniprotkb:Q64320|uniprotkb:Q96TG8|uniprotkb:Q28208|uniprotkb:Q62759|ensembl:ENSBTAP00000004589 psi-mi:snp25_bovin(display_long)|uniprotkb:SNAP25(gene name)|psi-mi:SNAP25(display_short)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym) psi-mi:stxb1_bovin(display_long)|uniprotkb:STXBP1(gene name)|psi-mi:STXBP1(display_short)|uniprotkb:UNC18A(gene name synonym)|uniprotkb:N-Sec1(gene name synonym)|uniprotkb:p67(gene name synonym)|uniprotkb:Protein unc-18 homolog 1(gene name synonym)|uniprotkb:Protein unc-18 homolog A(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Connell et al. (2007) pubmed:17363971|imex:IM-10861|mint:MINT-5219782 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7336257|mint:MINT-4545186|imex:IM-10861-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001069714.1|ensembl:ENSBTAG00000008323(gene)|ensembl:ENSBTAT00000010961(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:Q17QQ3|mint:MINT-4545191(identity) refseq:NP_777044.1|ensembl:ENSBTAG00000003525(gene)|ensembl:ENSBTAT00000004589(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007412"(axon target recognition)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0098793"(presynapse)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|mint:P61763|mint:MINT-4545187(identity) - comment:mint comment:mint|function:"May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions" figure legend:F3E|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-brain)|taxid:9913(Bos taurus brain) - 2007/04/26 2014/10/16 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs9913 rogid:yUYi89hDkfMdQ1BdH52swZQFCLk9913 intact-crc:F096826CC05CD932|rigid:d15lDx1t8ApMhSKlwqSik4MCKXw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P61763 uniprotkb:P32850 intact:EBI-7335973|intact:MINT-4545076|uniprotkb:Q64320|uniprotkb:Q96TG8|uniprotkb:Q28208|uniprotkb:Q62759|ensembl:ENSBTAP00000004589 intact:EBI-7336000|intact:MINT-1214927|ensembl:ENSBTAP00000064870 psi-mi:stxb1_bovin(display_long)|uniprotkb:STXBP1(gene name)|psi-mi:STXBP1(display_short)|uniprotkb:UNC18A(gene name synonym)|uniprotkb:N-Sec1(gene name synonym)|uniprotkb:p67(gene name synonym)|uniprotkb:Protein unc-18 homolog 1(gene name synonym)|uniprotkb:Protein unc-18 homolog A(gene name synonym) psi-mi:stx1a_bovin(display_long)|uniprotkb:STX1A(gene name)|psi-mi:STX1A(display_short)|uniprotkb:Synaptotagmin-associated 35 kDa protein(gene name synonym)|uniprotkb:Neuron-specific antigen HPC-1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Connell et al. (2007) pubmed:17363971|imex:IM-10861|mint:MINT-5219782 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7336285|mint:MINT-4545201|imex:IM-10861-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_777044.1|ensembl:ENSBTAG00000003525(gene)|ensembl:ENSBTAT00000004589(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007412"(axon target recognition)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0098793"(presynapse)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|mint:P61763|mint:MINT-4545206(identity) refseq:XP_005225301.1|ensembl:ENSBTAG00000017075(gene)|ensembl:ENSBTAT00000084274(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0043005"(neuron projection)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048278"(vesicle docking)|go:"GO:0048787"(presynaptic active zone membrane)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028669|mint:P32850|mint:MINT-4545202(identity) - comment:mint|function:"May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions" comment:mint|function:Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis figure legend:F3E|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9913(bovin-brain)|taxid:9913(Bos taurus brain) - 2007/04/26 2014/10/16 rogid:yUYi89hDkfMdQ1BdH52swZQFCLk9913 rogid:dqHojUrfJV598kiWyqciw2UsqKo9913 intact-crc:BEEBEF9D29F32E7C|rigid:y7FaqgqzsE+fphDrID/fvAnihG4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)