#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9C103	uniprotkb:P87231	intact:EBI-7326747|intact:MINT-4788648|ensemblfungi:"SPAPB1E7.06c.1:pep"	intact:EBI-7326720|intact:MINT-4692881|uniprotkb:Q2EEM1|ensemblfungi:"SPCC4G3.05c.1:pep"	psi-mi:eme1_schpo(display_long)|uniprotkb:eme1(gene name)|psi-mi:eme1(display_short)|uniprotkb:mms4(gene name synonym)|uniprotkb:slx2(gene name synonym)|uniprotkb:SPAPB1E7.06c(orf name)|uniprotkb:Essential meiotic endonuclease 1(gene name synonym)	psi-mi:mus81_schpo(display_long)|uniprotkb:mus81(gene name)|psi-mi:mus81(display_short)|uniprotkb:SPCC4G3.05c(orf name)	psi-mi:"MI:0071"(molecular sieving)	Gaskell et al. (2007)	pubmed:17363897|imex:IM-10933|mint:MINT-5219764	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7326769|mint:MINT-4788662|imex:IM-10933-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q9C103|interpro:IPR033310|refseq:NP_594132.2|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|ensemblfungi:SPAPB1E7.06c(gene)|ensemblfungi:SPAPB1E7.06c.1(transcript)|go:"GO:0000709"(meiotic joint molecule formation)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008821"(crossover junction endodeoxyribonuclease activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048476"(Holliday junction resolvase complex)|reactome:R-SPO-5693568|interpro:IPR042530|mint:MINT-4788663(identity)	interpro:IPR036388|mint:P87231|interpro:IPR011335(Restriction endonuclease, type II-like, core)|refseq:XP_001713161.1|ensemblfungi:SPCC4G3.05c(gene)|ensemblfungi:SPCC4G3.05c.1(transcript)|go:"GO:0000709"(meiotic joint molecule formation)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008821"(crossover junction endodeoxyribonuclease activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048257"(3'-flap endonuclease activity)|go:"GO:0048476"(Holliday junction resolvase complex)|reactome:R-SPO-5693568|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR042530|interpro:IPR027421|mint:MINT-4788664(identity)	-	comment:mint|function:"Interacts with mus81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI)"	comment:mint|function:"Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI)"	figure legend:F2|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/05/29	2014/10/16	rogid:oF2KUeFMxVkm4WWZVSGtY0FCMh8284812	rogid:VXJGyVVmDTISYyTWPYayjkyKccM284812	intact-crc:4D245C6423D31420|rigid:Nn/N/f4Kvxf3tC1Iu8kr5zsZU/c	false	his tag:?-?(MINT-4788672)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38257	uniprotkb:Q04149	intact:EBI-21547|uniprotkb:P38259|uniprotkb:Q6B1Z9|uniprotkb:D6VQ99|uniprotkb:Q9URQ2|ensemblfungi:YBR098W	intact:EBI-33508|uniprotkb:D6VT20|ensemblfungi:YDR386W	psi-mi:mms4_yeast(display_long)|uniprotkb:MMS4(gene name)|psi-mi:MMS4(display_short)|uniprotkb:SLX2(gene name synonym)|uniprotkb:YBR0826(orf name)|uniprotkb:YBR0829(orf name)|uniprotkb:YBR100W(orf name)|uniprotkb:YBR098W(locus name)	psi-mi:mus81_yeast(display_long)|uniprotkb:MUS81(gene name)|psi-mi:MUS81(display_short)|uniprotkb:SLX3(gene name synonym)|uniprotkb:YDR386W(locus name)|uniprotkb:D9509.6(orf name)|uniprotkb:MMS and UV-sensitive protein 81(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Gaskell et al. (2007)	pubmed:17363897|imex:IM-10933|mint:MINT-5219764	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7326813|mint:MINT-4788678|imex:IM-10933-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009656.2|sgd:S000000302|mint:P38257|dip:DIP-2927N|ensemblfungi:YBR098W(gene)|ensemblfungi:YBR098W_mRNA(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0010520"(regulation of reciprocal meiotic recombination)|go:"GO:0031297"(replication fork processing)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048476"(Holliday junction resolvase complex)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|reactome:R-SCE-5693568|mint:MINT-4788679(identity)	sgd:S000002794|refseq:NP_010674.3|mint:Q04149|dip:DIP-1009N|ensemblfungi:YDR386W(gene)|ensemblfungi:YDR386W_mRNA(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003677"(DNA binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048257"(3'-flap endonuclease activity)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0051097"(negative regulation of helicase activity)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR027421|interpro:IPR036388|interpro:IPR042530|reactome:R-SCE-5693568|mint:MINT-4788683(identity)	-	crc64:3B3918DD3B2E7E0C	crc64:F73FA3856C5F87F1	figure legend:SF2|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/05/29	2014/10/16	rogid:VhqWYn+gxagoC94RBwdOyQJWU4w559292	rogid:4p09mOMXnNcLuspURjjdB4S8Vkc559292	intact-crc:0F2610980ABE0864|rigid:yuEafuCa5ZNLLfNDJBtIU1jlro4	false	his tag:?-?(MINT-4788680)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)