#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q92574	uniprotkb:Q00994	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-741753|uniprotkb:Q5JQT4|uniprotkb:Q5JQT5|uniprotkb:B2RD17|uniprotkb:D3DXA3|ensembl:ENSP00000361718|ensembl:ENSP00000361728	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:bex3_human(display_long)|uniprotkb:BEX3(gene name)|psi-mi:BEX3(display_short)|uniprotkb:Brain-expressed X-linked protein 3(gene name synonym)|uniprotkb:DXS6984E(gene name synonym)|uniprotkb:NADE(gene name synonym)|uniprotkb:NGFRAP1(gene name synonym)|uniprotkb:Nerve growth factor receptor-associated protein 1(gene name synonym)|uniprotkb:Ovarian granulosa cell 13.0 kDa protein HGR74(gene name synonym)|uniprotkb:p75NTR-associated cell death executor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1386651|imex:IM-19197-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_055195.1|refseq:NP_996798.1|refseq:NP_996800.1|ensembl:ENSG00000166681(gene)|ensembl:ENST00000372635(transcript)|ensembl:ENST00000372645(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005163"(nerve growth factor receptor binding)|rcsb pdb:1SA6|reactome:R-HSA-205025|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007623(Brain expressed X-linked like protein)|interpro:IPR021156|mint:Q00994	-	-	-	figure legend:Table S1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/08/24	2014/10/16	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:vG0PO2+fbllJpBTuFohFVN9Ar8g9606	intact-crc:70436EA698148374|rigid:HzGugwaepfRrt8iW93VyekvFGPQ	false	sufficient binding region:674-1084	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P02794	uniprotkb:Q92574	intact:EBI-713259|uniprotkb:Q3KRA8|uniprotkb:Q3SWW1|ensembl:ENSP00000273550|ensembl:ENSP00000484477|uniprotkb:B3KNR5	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:frih_human(display_long)|uniprotkb:Cell proliferation-inducing gene 15 protein(gene name synonym)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)|uniprotkb:FTH(gene name synonym)|uniprotkb:FTHL6(gene name synonym)|uniprotkb:PIG15(orf name)|uniprotkb:OK/SW-cl.84(orf name)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1386658|imex:IM-19197-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002023.2|ensembl:ENSG00000167996(gene)|ensembl:ENST00000273550(transcript)|ensembl:ENST00000620041(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006880"(intracellular sequestering of iron ion)|go:"GO:0006955"(immune response)|go:"GO:0008043"(intracellular ferritin complex)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0044754"(autolysosome)|mint:P02794|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1FHA|rcsb pdb:2CEI|rcsb pdb:2CHI|rcsb pdb:2CIH|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001519(Ferritin, N-terminal)|interpro:IPR008331(Ferritin and Dps)|interpro:IPR009040(Ferritin-like)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012347(Ferritin-related)|interpro:IPR014034(Ferritin, conserved site)|rcsb pdb:2CLU|rcsb pdb:2CN6|rcsb pdb:2CN7|rcsb pdb:2FHA|rcsb pdb:2IU2|rcsb pdb:2Z6M|rcsb pdb:3AJO|rcsb pdb:3AJP|rcsb pdb:3AJQ|rcsb pdb:3ERZ|rcsb pdb:3ES3|rcsb pdb:4DYX|rcsb pdb:4DYY|rcsb pdb:4DYZ|rcsb pdb:4Y08|rcsb pdb:4YKH|rcsb pdb:4ZJK|rcsb pdb:5CMQ|rcsb pdb:5CMR|rcsb pdb:5GN8|rcsb pdb:5GOU|rcsb pdb:5JKK|rcsb pdb:5JKL|rcsb pdb:5JKM|rcsb pdb:5N26|rcsb pdb:5N27|rcsb pdb:5UP7|rcsb pdb:5UP8|rcsb pdb:5UP9|rcsb pdb:5VTD|rcsb pdb:5XB1|rcsb pdb:5YI5|rcsb pdb:5ZND|rcsb pdb:6B8F|rcsb pdb:6B8G|rcsb pdb:4DZ0|rcsb pdb:6FTV|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6H6T|rcsb pdb:6H6U|rcsb pdb:6IPC|rcsb pdb:6IPO|rcsb pdb:6IPP|rcsb pdb:6IPQ|rcsb pdb:6J4A|rcsb pdb:6J7G|rcsb pdb:6JOB|rcsb pdb:6JPS|rcsb pdb:6KE2|rcsb pdb:6KE4|rcsb pdb:4OYN|rcsb pdb:6M52|rcsb pdb:6M54|rcsb pdb:6WYF|rcsb pdb:6WYG|rcsb pdb:6WYH|rcsb pdb:6Z6U|rcsb pdb:6Z9E|rcsb pdb:6Z9F|rcsb pdb:7A6A|rcsb pdb:7A6B|rcsb pdb:7CK8|rcsb pdb:7CK9|rcsb pdb:7JGK|rcsb pdb:7JGL|rcsb pdb:7JGM|rcsb pdb:7JGN|rcsb pdb:7JGO|rcsb pdb:7JGP|rcsb pdb:7JGQ|rcsb pdb:7K26|rcsb pdb:7K3V|rcsb pdb:7K3W|reactome:R-HSA-3000480|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-917937|dip:DIP-38301N	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	-	-	-	figure legend:Table S1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/08/24	2014/10/16	rogid:TchHgRpv+inA8BQ5i0OHaa267tQ9606	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	intact-crc:90EA9309AEE9CD5B|rigid:/dEAsMaVAr2dxEUpBCqqfyC2+XU	false	-	sufficient binding region:674-1084	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51948	uniprotkb:Q92574	intact:EBI-716139|uniprotkb:Q15817|uniprotkb:G3V1U8|uniprotkb:Q6ICQ7|ensembl:ENSP00000261245	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:mat1_human(display_long)|uniprotkb:RING finger protein MAT1(gene name synonym)|uniprotkb:Menage a trois(gene name synonym)|uniprotkb:CDK7/cyclin-H assembly factor(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Cyclin-G1-interacting protein(gene name synonym)|uniprotkb:RING finger protein 66(gene name synonym)|uniprotkb:MNAT1(gene name)|psi-mi:MNAT1(display_short)|uniprotkb:CAP35(gene name synonym)|uniprotkb:MAT1(gene name synonym)|uniprotkb:RNF66(gene name synonym)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1386662|imex:IM-19197-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171434.1|refseq:NP_002422.1|interpro:IPR017907|rcsb pdb:1G25|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6TUN|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|interpro:IPR015877(Cdk-activating kinase assembly factor, MAT1)|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|ensembl:ENST00000261245(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007512"(adult heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0021591"(ventricular system development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051592"(response to calcium ion)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070985"(transcription factor TFIIK complex)|ensembl:ENSG00000020426(gene)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR004575("Cdk-activating kinase assembly factor (MAT1)")|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|reactome:R-HSA-8939236|refseq:XP_005267744.1	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	-	-	-	figure legend:Table S1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/08/24	2014/10/16	rogid:5Y/RExMrWjtftdbXuadagc0b+Kc9606	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	intact-crc:71EDB0E034A8202F|rigid:OMlgYnogHbQe0zTqBRQtAxW15gY	false	-	sufficient binding region:674-1084	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q86SQ7	uniprotkb:Q92574	intact:EBI-1047850|uniprotkb:Q3ZCR6|uniprotkb:Q8N5F2|uniprotkb:Q9P0F1|uniprotkb:O60527|ensembl:ENSP00000355499|ensembl:ENSP00000483550	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:sdcg8_human(display_long)|uniprotkb:Antigen NY-CO-8(gene name synonym)|uniprotkb:Centrosomal colon cancer autoantigen protein(gene name synonym)|uniprotkb:SDCCAG8(gene name)|psi-mi:SDCCAG8(display_short)|uniprotkb:CCCAP(gene name synonym)|uniprotkb:NPHP10(gene name synonym)|uniprotkb:HSPC085(orf name)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1386666|imex:IM-19197-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006633.1|ensembl:ENSG00000054282(gene)|ensembl:ENSG00000276111(gene)|ensembl:ENST00000366541(transcript)|ensembl:ENST00000622598(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007098"(centrosome cycle)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030030"(cell projection organization)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035148"(tube formation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0097733"(photoreceptor cell cilium)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR031887|mint:Q86SQ7|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:XP_005273080.1	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	-	-	-	figure legend:Table S1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/08/24	2014/10/16	rogid:Z3ynDtbmAV7usLzKH+M3Ilf6Ebw9606	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	intact-crc:9D0A4CFCE3E5CA95|rigid:EuYmFze8yNutdqmrfWPckuT0V4E	false	-	sufficient binding region:674-1084	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q92574	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1386670|imex:IM-19197-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	-	-	-	figure legend:Table S1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/08/24	2014/10/16	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	intact-crc:E94E150B2B646738|rigid:NUlxOyE7bkTK2WMNEVI127QJh78	false	sufficient binding region:674-1084	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q6PF11	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-1386691	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:q6pf11_human(display_long)|uniprotkb:CSH1(gene name)|psi-mi:CSH1(display_short)	psi-mi:"MI:0018"(two hybrid)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1386699|imex:IM-19197-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR001400(Somatotropin hormone)|interpro:IPR018116|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)	-	-	-	figure legend:Table S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/08/24	2014/10/16	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:wxDIdyufZj/OAtaNHDnVEuwmpBU9606	intact-crc:62F4E4D6322FB47D|rigid:7jNJbAyTnDYAQztVzYB0amgQbyY	false	sufficient binding region:674-1084	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q00994	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-741753|uniprotkb:Q5JQT4|uniprotkb:Q5JQT5|uniprotkb:B2RD17|uniprotkb:D3DXA3|ensembl:ENSP00000361718|ensembl:ENSP00000361728	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:bex3_human(display_long)|uniprotkb:BEX3(gene name)|psi-mi:BEX3(display_short)|uniprotkb:Brain-expressed X-linked protein 3(gene name synonym)|uniprotkb:DXS6984E(gene name synonym)|uniprotkb:NADE(gene name synonym)|uniprotkb:NGFRAP1(gene name synonym)|uniprotkb:Nerve growth factor receptor-associated protein 1(gene name synonym)|uniprotkb:Ovarian granulosa cell 13.0 kDa protein HGR74(gene name synonym)|uniprotkb:p75NTR-associated cell death executor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1386703|imex:IM-19197-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_055195.1|refseq:NP_996798.1|refseq:NP_996800.1|ensembl:ENSG00000166681(gene)|ensembl:ENST00000372635(transcript)|ensembl:ENST00000372645(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005163"(nerve growth factor receptor binding)|rcsb pdb:1SA6|reactome:R-HSA-205025|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007623(Brain expressed X-linked like protein)|interpro:IPR021156|mint:Q00994	-	-	-	figure legend:Table S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/08/24	2014/10/16	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:vG0PO2+fbllJpBTuFohFVN9Ar8g9606	intact-crc:13143CB851473090|rigid:HzGugwaepfRrt8iW93VyekvFGPQ	false	sufficient binding region:674-1084	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:P69905	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-714680|uniprotkb:P01922|ensembl:ENSP00000251595|ensembl:ENSP00000322421|uniprotkb:Q3MIF5|uniprotkb:Q96KF1|uniprotkb:Q9NYR7|uniprotkb:Q1HDT5|uniprotkb:Q53F97|uniprotkb:Q9UCM0	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:hba_human(display_long)|uniprotkb:Hemoglobin alpha chain(gene name synonym)|uniprotkb:Alpha-globin(gene name synonym)|uniprotkb:HBA1(gene name)|psi-mi:HBA1(display_short)|uniprotkb:HBA2(gene name)|psi-mi:HBA2(display_short)	psi-mi:"MI:0018"(two hybrid)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1386707|imex:IM-19197-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENSG00000188536(gene)|ensembl:ENSG00000206172(gene)|ensembl:ENST00000251595(transcript)|ensembl:ENST00000320868(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015671"(oxygen transport)|go:"GO:0016020"(membrane)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0072562"(blood microparticle)|go:"GO:0098869"(cellular oxidant detoxification)|interpro:IPR000971(Globin, subset)|interpro:IPR002338(Haemoglobin, alpha)|interpro:IPR002339(Haemoglobin, pi)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|mint:P69905|rcsb pdb:1A00|rcsb pdb:1A01|rcsb pdb:1A0U|rcsb pdb:1A0Z|rcsb pdb:1A3N|rcsb pdb:1A3O|rcsb pdb:1A9W|rcsb pdb:1ABW|rcsb pdb:1ABY|rcsb pdb:1AJ9|rcsb pdb:1B86|rcsb pdb:1BAB|rcsb pdb:1BBB|rcsb pdb:1BIJ|rcsb pdb:1BUW|rcsb pdb:1BZ0|rcsb pdb:1BZ1|rcsb pdb:1BZZ|rcsb pdb:1C7B|rcsb pdb:1C7C|rcsb pdb:1C7D|rcsb pdb:1CLS|rcsb pdb:1CMY|rcsb pdb:1COH|rcsb pdb:1DKE|rcsb pdb:1DXT|rcsb pdb:1DXU|rcsb pdb:1DXV|rcsb pdb:1FDH|rcsb pdb:1FN3|rcsb pdb:1G9V|rcsb pdb:1YVQ|rcsb pdb:1YVT|rcsb pdb:1YZI|rcsb pdb:1Z8U|rcsb pdb:2D5Z|rcsb pdb:2D60|rcsb pdb:2DN1|rcsb pdb:2DN2|rcsb pdb:2DN3|rcsb pdb:2DXM|rcsb pdb:2H35|rcsb pdb:2HBC|rcsb pdb:2HBD|rcsb pdb:2HBE|rcsb pdb:2HBF|rcsb pdb:2HBS|rcsb pdb:2HCO|rcsb pdb:2HHB|rcsb pdb:2HHD|rcsb pdb:2HHE|rcsb pdb:2M6Z|rcsb pdb:2W6V|rcsb pdb:2W72|rcsb pdb:2YRS|rcsb pdb:3B75|rcsb pdb:3D17|rcsb pdb:3D7O|rcsb pdb:3DUT|rcsb pdb:3HHB|rcsb pdb:3HXN|rcsb pdb:3IA3|rcsb pdb:3IC0|rcsb pdb:3IC2|rcsb pdb:3KMF|rcsb pdb:3NL7|rcsb pdb:3NMM|rcsb pdb:3ODQ|rcsb pdb:3ONZ|rcsb pdb:3OO4|rcsb pdb:3OO5|rcsb pdb:3OVU|rcsb pdb:3P5Q|rcsb pdb:3QJB|rcsb pdb:3QJC|rcsb pdb:3QJD|rcsb pdb:3QJE|rcsb pdb:3R5I|rcsb pdb:3S48|rcsb pdb:3S65|rcsb pdb:3S66|rcsb pdb:3SZK|rcsb pdb:3WCP|rcsb pdb:3WHM|rcsb pdb:4FC3|rcsb pdb:4HHB|rcsb pdb:4IJ2|rcsb pdb:4L7Y|rcsb pdb:4M4A|rcsb pdb:4M4B|rcsb pdb:4MQC|rcsb pdb:4MQG|rcsb pdb:4MQH|rcsb pdb:4MQI|rcsb pdb:4MQJ|rcsb pdb:4MQK|rcsb pdb:4X0L|rcsb pdb:4XS0|rcsb pdb:5E29|rcsb pdb:5E6E|rcsb pdb:5E83|rcsb pdb:5EE4|rcsb pdb:5HU6|rcsb pdb:5HY8|rcsb pdb:5JDO|rcsb pdb:5KDQ|rcsb pdb:5KSI|rcsb pdb:5KSJ|rcsb pdb:5NI1|rcsb pdb:5SW7|rcsb pdb:5U3I|rcsb pdb:5UCU|rcsb pdb:5UFJ|rcsb pdb:5URC|rcsb pdb:5VMM|rcsb pdb:5WOG|rcsb pdb:5WOH|rcsb pdb:5X2R|rcsb pdb:5X2S|rcsb pdb:5X2T|rcsb pdb:5X2U|rcsb pdb:6BB5|rcsb pdb:6BNR|rcsb pdb:6BWP|rcsb pdb:6BWU|rcsb pdb:6DI4|rcsb pdb:6HAL|rcsb pdb:6HBW|rcsb pdb:6HK2|rcsb pdb:6KA9|rcsb pdb:6KAE|rcsb pdb:6KAH|rcsb pdb:6KAI|rcsb pdb:6KAO|rcsb pdb:6KAP|rcsb pdb:6KAQ|rcsb pdb:6KAR|rcsb pdb:6KAS|rcsb pdb:6KAT|rcsb pdb:4N7N|rcsb pdb:6KAU|rcsb pdb:4N7O|rcsb pdb:4N7P|rcsb pdb:6KAV|rcsb pdb:4N8T|rcsb pdb:6KYE|rcsb pdb:6L5V|rcsb pdb:6L5W|rcsb pdb:6L5X|rcsb pdb:6L5Y|rcsb pdb:6LCW|rcsb pdb:6LCX|rcsb pdb:4NI0|rcsb pdb:4NI1|rcsb pdb:4ROL|rcsb pdb:4ROM|rcsb pdb:4WJG|rcsb pdb:6NBC|rcsb pdb:6NBD|rcsb pdb:6NQ5|rcsb pdb:6TB2|rcsb pdb:6XD9|rcsb pdb:6XDT|rcsb pdb:6XE7|rcsb pdb:7AET|rcsb pdb:7AEV|rcsb pdb:7JJQ|rcsb pdb:7JXZ|rcsb pdb:7JY0|rcsb pdb:7JY1|rcsb pdb:7JY3|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-2168880|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:7AEU|refseq:NP_000508.1|refseq:NP_000549.1|rcsb pdb:1GBU|rcsb pdb:1GBV|rcsb pdb:1GLI|rcsb pdb:1GZX|rcsb pdb:1HAB|rcsb pdb:1HAC|rcsb pdb:1HBA|rcsb pdb:1HBB|rcsb pdb:1HBS|rcsb pdb:1HCO|rcsb pdb:1HDB|rcsb pdb:1HGA|rcsb pdb:1HGB|rcsb pdb:1HGC|rcsb pdb:1HHO|rcsb pdb:1IRD|rcsb pdb:1J3Y|rcsb pdb:1J3Z|rcsb pdb:1J40|rcsb pdb:1J41|rcsb pdb:1J7S|rcsb pdb:1J7W|rcsb pdb:1J7Y|rcsb pdb:1JY7|rcsb pdb:1K0Y|rcsb pdb:1K1K|rcsb pdb:1KD2|rcsb pdb:1LFL|rcsb pdb:1LFQ|rcsb pdb:1LFT|rcsb pdb:1LFV|rcsb pdb:1LFY|rcsb pdb:1LFZ|rcsb pdb:1LJW|rcsb pdb:1M9P|rcsb pdb:1MKO|rcsb pdb:1NEJ|rcsb pdb:1NIH|rcsb pdb:1NQP|rcsb pdb:1O1I|rcsb pdb:1O1J|rcsb pdb:1O1K|rcsb pdb:1O1L|rcsb pdb:1O1M|rcsb pdb:1O1N|rcsb pdb:1O1O|rcsb pdb:1O1P|rcsb pdb:1QI8|rcsb pdb:1QSH|rcsb pdb:1QSI|rcsb pdb:1QXD|rcsb pdb:1QXE|rcsb pdb:1R1X|rcsb pdb:1R1Y|rcsb pdb:1RPS|rcsb pdb:1RQ3|rcsb pdb:1RQ4|rcsb pdb:1RQA|rcsb pdb:1RVW|rcsb pdb:1SDK|rcsb pdb:1SDL|rcsb pdb:1SHR|rcsb pdb:1SI4|rcsb pdb:1THB|rcsb pdb:1UIW|rcsb pdb:1VWT|rcsb pdb:1XXT|rcsb pdb:1XY0|rcsb pdb:1XYE|rcsb pdb:1XZ2|rcsb pdb:1XZ4|rcsb pdb:1XZ5|rcsb pdb:1XZ7|rcsb pdb:1XZU|rcsb pdb:1XZV|rcsb pdb:1Y01|rcsb pdb:1Y09|rcsb pdb:1Y0A|rcsb pdb:1Y0C|rcsb pdb:1Y0D|rcsb pdb:1Y0T|rcsb pdb:1Y0W|rcsb pdb:1Y22|rcsb pdb:1Y2Z|rcsb pdb:1Y31|rcsb pdb:1Y35|rcsb pdb:1Y45|rcsb pdb:1Y46|rcsb pdb:1Y4B|rcsb pdb:1Y4F|rcsb pdb:1Y4G|rcsb pdb:1Y4P|rcsb pdb:1Y4Q|rcsb pdb:1Y4R|rcsb pdb:1Y4V|rcsb pdb:1Y5F|rcsb pdb:1Y5J|rcsb pdb:1Y5K|rcsb pdb:1Y7C|rcsb pdb:1Y7D|rcsb pdb:1Y7G|rcsb pdb:1Y7Z|rcsb pdb:1Y83|rcsb pdb:1Y85|rcsb pdb:1Y8W|rcsb pdb:1YDZ|rcsb pdb:1YE0|rcsb pdb:1YE1|rcsb pdb:1YE2|rcsb pdb:1YEN|rcsb pdb:1YEO|rcsb pdb:1YEQ|rcsb pdb:1YEU|rcsb pdb:1YEV|rcsb pdb:1YFF|rcsb pdb:1YG5|rcsb pdb:1YGD|rcsb pdb:1YGF|rcsb pdb:1YH9|rcsb pdb:1YHE|rcsb pdb:1YHR|rcsb pdb:1YIE|rcsb pdb:1YIH|dip:DIP-35199N	-	-	-	figure legend:Table S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/08/24	2014/10/16	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:M4o0FF1DIrouBdyFXr4UtAlcjZw9606	intact-crc:AB5557781D6FAEAF|rigid:SOEL7v7avAPXbOR0RjKwHuMNHVI	false	sufficient binding region:674-1084	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q9BXF6	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-1387068|uniprotkb:O94939|uniprotkb:Q9P0M1|ensembl:ENSP00000258098	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:rfip5_human(display_long)|uniprotkb:RAB11FIP5(gene name)|psi-mi:RAB11FIP5(display_short)|uniprotkb:GAF1(gene name synonym)|uniprotkb:KIAA0857(gene name synonym)|uniprotkb:RIP11(gene name synonym)|uniprotkb:Rab11-interacting protein Rip11(gene name synonym)|uniprotkb:Gamma-SNAP-associated factor 1(gene name synonym)|uniprotkb:Phosphoprotein pp75(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1387081|imex:IM-19197-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_056285.1|ensembl:ENSG00000135631(gene)|ensembl:ENST00000258098(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0030141"(secretory granule)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070164"(negative regulation of adiponectin secretion)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:2000008"(regulation of protein localization to cell surface)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR019018|interpro:IPR035892|interpro:IPR037245|interpro:IPR037789|mint:Q9BXF6|go:"GO:0034451"(centriolar satellite)	-	-	-	figure legend:Table S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/08/24	2014/10/16	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:X3eYUlRpL+nSmU4gfUEA5RntseY9606	intact-crc:F61AFF2E344B7691|rigid:UNHyIprysCb6DokUeuyFiZzBg/c	false	sufficient binding region:674-1084	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:P08962	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-762053|uniprotkb:Q5TZP3|uniprotkb:Q9UCG6|uniprotkb:Q8N6Z9|uniprotkb:F8VZE2|ensembl:ENSP00000257857|ensembl:ENSP00000393502|ensembl:ENSP00000447730|ensembl:ENSP00000449337	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:cd63_human(display_long)|uniprotkb:Melanoma-associated antigen ME491(gene name synonym)|uniprotkb:Ocular melanoma-associated antigen(gene name synonym)|uniprotkb:OMA81H(gene name synonym)|uniprotkb:Granulophysin(gene name synonym)|uniprotkb:Tetraspanin-30(gene name synonym)|uniprotkb:Lysosomal-associated membrane protein 3(gene name synonym)|uniprotkb:CD63(gene name)|psi-mi:CD63(display_short)|uniprotkb:MLA1(gene name synonym)|uniprotkb:TSPAN30(gene name synonym)|uniprotkb:Lysosome integral membrane protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1387085|imex:IM-19197-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001771.1|refseq:NP_001244330.1|refseq:NP_001244318.1|refseq:NP_001244319.1|refseq:NP_001244320.1|refseq:NP_001244329.1|refseq:NP_001254627.1|refseq:NP_001244321.1|ensembl:ENSG00000135404(gene)|ensembl:ENST00000257857(transcript)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|interpro:IPR042028|mint:P08962|reactome:R-HSA-114608|reactome:R-HSA-6798695|go:"GO:0097487"(multivesicular body, internal vesicle)|ensembl:ENST00000420846(transcript)|ensembl:ENST00000549117(transcript)|ensembl:ENST00000552692(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016477"(cell migration)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048757"(pigment granule maturation)|go:"GO:0070062"(extracellular exosome)	-	-	-	figure legend:Table S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/08/24	2014/10/16	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:stCGi5kkTMIdO84qSwjmjpUwwvs9606	intact-crc:1B66E3C367C73B20|rigid:L3xCQMJuBE+B/ZZ+QK5B/B31xro	false	sufficient binding region:674-1084	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O96000	uniprotkb:Q92574	intact:EBI-1246371|uniprotkb:Q96II6|ensembl:ENSP00000268668	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:nduba_human(display_long)|uniprotkb:NDUFB10(gene name)|psi-mi:NDUFB10(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase PDSW subunit(gene name synonym)|uniprotkb:Complex I-PDSW(gene name synonym)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1387089|imex:IM-19197-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004539.1|ensembl:ENSG00000140990(gene)|ensembl:ENST00000268668(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|interpro:IPR019377|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR039993|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|dip:DIP-38298N	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	-	-	-	figure legend:Table S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/08/24	2014/10/16	rogid:CRQJLj/I1jZSnIU7GeuRDGN4hRA9606	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	intact-crc:57E0B10449584687|rigid:kpfqF/xOoJubC+NxP+vsV/8pNU4	false	-	sufficient binding region:674-1084	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q02535	uniprotkb:Q92574	intact:EBI-1387094|uniprotkb:O75641|uniprotkb:A8K1T8|ensembl:ENSP00000363689|ensembl:ENSP00000489102	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:id3_human(display_long)|uniprotkb:ID3(gene name)|psi-mi:ID3(display_short)|uniprotkb:1R21(gene name synonym)|uniprotkb:BHLHB25(gene name synonym)|uniprotkb:Inhibitor of DNA binding 3(gene name synonym)|uniprotkb:ID-like protein inhibitor HLH 1R21(gene name synonym)|uniprotkb:Helix-loop-helix protein HEIR-1(gene name synonym)|uniprotkb:HEIR1(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 25(gene name synonym)|uniprotkb:Inhibitor of differentiation 3(gene name synonym)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1387107|imex:IM-19197-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002158.3|dip:DIP-713N|ensembl:ENSG00000117318(gene)|ensembl:ENSG00000283060(gene)|ensembl:ENST00000374561(transcript)|ensembl:ENST00000634790(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001656"(metanephros development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030903"(notochord development)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042476"(odontogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0072750"(cellular response to leptomycin B)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901707"(leptomycin B binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR026052|interpro:IPR036638|rcsb pdb:2LFH|reactome:R-HSA-9031628	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	-	-	-	figure legend:Table S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/08/24	2014/10/16	rogid:EOy/Sn41BQc0qA/LeWAJGBxXqRI9606	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	intact-crc:F87D26021F981291|rigid:GKHNyS+VtjRTSQU4wjO3OPc4E7c	false	-	sufficient binding region:674-1084	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P20936	uniprotkb:Q92574	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1387111|imex:IM-19197-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	-	-	-	figure legend:Table S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/08/24	2014/10/16	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	intact-crc:85DF6CB1B7A97E44|rigid:ftgqk9nBtm7y+xBFO42CuNeoG38	false	-	sufficient binding region:674-1084	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P60709	uniprotkb:Q92574	intact:EBI-353944|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|uniprotkb:Q64316|uniprotkb:Q75MN2|uniprotkb:Q96B34|uniprotkb:Q96HG5|ensembl:ENSP00000494269|ensembl:ENSP00000494750|ensembl:ENSP00000495995|ensembl:ENSP00000501862|ensembl:ENSP00000502821	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:actb_human(display_long)|uniprotkb:ACTB(gene name)|psi-mi:ACTB(display_short)|uniprotkb:Beta-actin(gene name synonym)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1387120|imex:IM-19197-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001092.1|ensembl:ENSG00000075624(gene)|ensembl:ENST00000493945(transcript)|ensembl:ENST00000642480(transcript)|ensembl:ENST00000646664(transcript)|ensembl:ENST00000674681(transcript)|ensembl:ENST00000675515(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000785"(chromatin)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043044"|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051623"(positive regulation of norepinephrine uptake)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070160"(tight junction)|go:"GO:0070527"(platelet aggregation)|reactome:R-HSA-4420097|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072562"(blood microparticle)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60709|rcsb pdb:3BYH|rcsb pdb:3D2U|rcsb pdb:3J82|rcsb pdb:3LUE|rcsb pdb:6ANU|rcsb pdb:6ICT|rcsb pdb:6ICV|rcsb pdb:6LTJ|rcsb pdb:6MBJ|rcsb pdb:6MBK|rcsb pdb:6MBL|rcsb pdb:6NBW|rcsb pdb:6OX0|rcsb pdb:6OX1|rcsb pdb:6OX2|rcsb pdb:6OX3|rcsb pdb:6OX4|rcsb pdb:6OX5|rcsb pdb:6V62|rcsb pdb:6V63|rcsb pdb:6WK1|rcsb pdb:6WK2|rcsb pdb:7AS4|reactome:R-HSA-1445148|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2029482|reactome:R-HSA-3214847|reactome:R-HSA-389957|reactome:R-HSA-390450|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-418990|reactome:R-HSA-437239|reactome:R-HSA-446353|reactome:R-HSA-5250924|reactome:R-HSA-5626467|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5674135|reactome:R-HSA-5689603|reactome:R-HSA-5696394|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856828|reactome:R-HSA-9035034|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9664422|reactome:R-HSA-983231|reactome:R-HSA-445095|dip:DIP-29686N	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	-	-	-	figure legend:Table S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/08/24	2014/10/16	rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc9606	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	intact-crc:71898B2792341CFC|rigid:a/0xckAlYYFmOEj5vDV6iqymBcg	false	-	sufficient binding region:674-1084	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P62736	uniprotkb:Q92574	intact:EBI-698810|uniprotkb:P03996|uniprotkb:P04108|uniprotkb:Q6FI19|uniprotkb:B2R8A4|ensembl:ENSP00000224784	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:acta_human(display_long)|uniprotkb:Alpha-actin-2(gene name synonym)|uniprotkb:Cell growth-inhibiting gene 46 protein(gene name synonym)|uniprotkb:ACTA2(gene name)|psi-mi:ACTA2(display_short)|uniprotkb:ACTSA(gene name synonym)|uniprotkb:ACTVS(gene name synonym)|uniprotkb:GIG46(orf name)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1387133|imex:IM-19197-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135417.1|refseq:NP_001604.1|refseq:NP_001307784.1|ensembl:ENSG00000107796(gene)|ensembl:ENST00000224784(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030485"(smooth muscle contractile fiber)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044297"(cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090131"(mesenchyme migration)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P62736|reactome:R-HSA-445355|reactome:R-HSA-9013695	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	-	-	-	figure legend:Table S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/08/24	2014/10/16	rogid:mRZGUdL/jBuj6nVHtxoasZuA7yA9606	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	intact-crc:59FF1F5E3169C6B7|rigid:E4T1mA/xEkxJ0y8nDxyRo3l3fcE	false	-	sufficient binding region:674-1084	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:P23246	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-355453|uniprotkb:P30808|uniprotkb:Q5SZ71|ensembl:ENSP00000349748	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:sfpq_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:100 kDa DNA-pairing protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1387142|imex:IM-19197-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_005057.1|ensembl:ENSG00000116560(gene)|ensembl:ENST00000357214(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0005634"(nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048511"(rhythmic process)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:P23246|rcsb pdb:4WII|rcsb pdb:4WIJ|rcsb pdb:4WIK|rcsb pdb:5WPA|rcsb pdb:6NCQ|rcsb pdb:6OWJ|rcsb pdb:6WMZ|rcsb pdb:7LRQ|rcsb pdb:7LRU|reactome:R-HSA-8849468|reactome:R-HSA-9635465|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|refseq:XP_005271169.1|refseq:XP_005271170.1|refseq:XP_005271172.1|refseq:XP_016857542.1|refseq:XP_016857543.1|dip:DIP-31272N	-	-	-	figure legend:Table S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/08/24	2014/10/16	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:B7mSc6tthLbSHo0qz0SMZBSl3HA9606	intact-crc:33419A13D4D8B7B2|rigid:OTjIK2gwpVDZgPGnhSTs/mxXoks	false	sufficient binding region:674-1084	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:O00303	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-711990|ensembl:ENSP00000431800|ensembl:ENSP00000499218|uniprotkb:Q6IB45|uniprotkb:Q8N978|uniprotkb:A8K0S2	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:eif3f_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 5(gene name synonym)|uniprotkb:eIF-3-epsilon(gene name synonym)|uniprotkb:eIF3 p47(gene name synonym)|uniprotkb:EIF3F(gene name)|psi-mi:EIF3F(display_short)|uniprotkb:EIF3S5(gene name synonym)|uniprotkb:Deubiquitinating enzyme eIF3f(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1387345|imex:IM-19197-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENSG00000175390(gene)|ensembl:ENST00000533626(transcript)|ensembl:ENST00000651655(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR027531|interpro:IPR037518|mint:O00303|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_003745.1|dip:DIP-35580N	-	-	-	figure legend:Table S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/08/24	2014/10/16	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:dpH1pTcPshcrSjNCdPPnkYiW0YU9606	intact-crc:336D955F83B2EA7E|rigid:m4NvrQcRcPpUOIRfFOlojvFFL1w	false	sufficient binding region:674-1084	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q02833	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-929013|ensembl:ENSP00000380713|ensembl:ENSP00000479652|uniprotkb:Q3KP42|intact:EBI-11052282|uniprotkb:G5E9N9|uniprotkb:Q3KP41	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:rasf7_human(display_long)|uniprotkb:RASSF7(gene name)|psi-mi:RASSF7(display_short)|uniprotkb:C11orf13(gene name synonym)|uniprotkb:HRC1(gene name synonym)|uniprotkb:HRAS1-related cluster protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1387361|imex:IM-19197-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENSG00000099849(gene)|ensembl:ENSG00000273859(gene)|ensembl:ENST00000397583(transcript)|ensembl:ENST00000622905(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0034451"(centriolar satellite)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|interpro:IPR000159(Ras-association)|interpro:IPR029071|interpro:IPR033593|interpro:IPR033631|refseq:NP_001137465.1|refseq:NP_001137466.1|refseq:NP_003466.1|refseq:XP_016873850.1|refseq:XP_016873851.1	-	-	-	figure legend:Table S2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/08/24	2014/10/16	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:p1j9prChoZIecLZDG02TGJ0Z76I9606	intact-crc:19C0CA195B19D0D8|rigid:fl3KpYQEgf9vwKwy9DJQkCF3d/o	false	sufficient binding region:674-1084	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q00994	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-741753|uniprotkb:Q5JQT4|uniprotkb:Q5JQT5|uniprotkb:B2RD17|uniprotkb:D3DXA3|ensembl:ENSP00000361718|ensembl:ENSP00000361728	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:bex3_human(display_long)|uniprotkb:BEX3(gene name)|psi-mi:BEX3(display_short)|uniprotkb:Brain-expressed X-linked protein 3(gene name synonym)|uniprotkb:DXS6984E(gene name synonym)|uniprotkb:NADE(gene name synonym)|uniprotkb:NGFRAP1(gene name synonym)|uniprotkb:Nerve growth factor receptor-associated protein 1(gene name synonym)|uniprotkb:Ovarian granulosa cell 13.0 kDa protein HGR74(gene name synonym)|uniprotkb:p75NTR-associated cell death executor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1387725|imex:IM-19197-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_055195.1|refseq:NP_996798.1|refseq:NP_996800.1|ensembl:ENSG00000166681(gene)|ensembl:ENST00000372635(transcript)|ensembl:ENST00000372645(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005163"(nerve growth factor receptor binding)|rcsb pdb:1SA6|reactome:R-HSA-205025|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007623(Brain expressed X-linked like protein)|interpro:IPR021156|mint:Q00994	-	-	-	figure legend:1 B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/08/24	2014/10/16	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:vG0PO2+fbllJpBTuFohFVN9Ar8g9606	intact-crc:9E13E0654C3BC3C1|rigid:HzGugwaepfRrt8iW93VyekvFGPQ	false	sufficient binding region:674-1084	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q00994	uniprotkb:Q92574	intact:EBI-741753|uniprotkb:Q5JQT4|uniprotkb:Q5JQT5|uniprotkb:B2RD17|uniprotkb:D3DXA3|ensembl:ENSP00000361718|ensembl:ENSP00000361728	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:bex3_human(display_long)|uniprotkb:BEX3(gene name)|psi-mi:BEX3(display_short)|uniprotkb:Brain-expressed X-linked protein 3(gene name synonym)|uniprotkb:DXS6984E(gene name synonym)|uniprotkb:NADE(gene name synonym)|uniprotkb:NGFRAP1(gene name synonym)|uniprotkb:Nerve growth factor receptor-associated protein 1(gene name synonym)|uniprotkb:Ovarian granulosa cell 13.0 kDa protein HGR74(gene name synonym)|uniprotkb:p75NTR-associated cell death executor(gene name synonym)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:0096"(pull down)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1387739|imex:IM-19197-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055195.1|refseq:NP_996798.1|refseq:NP_996800.1|ensembl:ENSG00000166681(gene)|ensembl:ENST00000372635(transcript)|ensembl:ENST00000372645(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005163"(nerve growth factor receptor binding)|rcsb pdb:1SA6|reactome:R-HSA-205025|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007623(Brain expressed X-linked like protein)|interpro:IPR021156|mint:Q00994	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	-	-	-	figure legend:1 C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/08/24	2014/10/16	rogid:vG0PO2+fbllJpBTuFohFVN9Ar8g9606	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	intact-crc:021679D5B48D58F3|rigid:HzGugwaepfRrt8iW93VyekvFGPQ	false	-	sufficient binding region:674-1084	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92574	uniprotkb:Q00994	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-741753|uniprotkb:Q5JQT4|uniprotkb:Q5JQT5|uniprotkb:B2RD17|uniprotkb:D3DXA3|ensembl:ENSP00000361718|ensembl:ENSP00000361728	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:bex3_human(display_long)|uniprotkb:BEX3(gene name)|psi-mi:BEX3(display_short)|uniprotkb:Brain-expressed X-linked protein 3(gene name synonym)|uniprotkb:DXS6984E(gene name synonym)|uniprotkb:NADE(gene name synonym)|uniprotkb:NGFRAP1(gene name synonym)|uniprotkb:Nerve growth factor receptor-associated protein 1(gene name synonym)|uniprotkb:Ovarian granulosa cell 13.0 kDa protein HGR74(gene name synonym)|uniprotkb:p75NTR-associated cell death executor(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1387764|imex:IM-19197-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_055195.1|refseq:NP_996798.1|refseq:NP_996800.1|ensembl:ENSG00000166681(gene)|ensembl:ENST00000372635(transcript)|ensembl:ENST00000372645(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005163"(nerve growth factor receptor binding)|rcsb pdb:1SA6|reactome:R-HSA-205025|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007623(Brain expressed X-linked like protein)|interpro:IPR021156|mint:Q00994	go:"GO:0005737"(cytoplasm)	-	-	figure legend:2 A|delivery method:Q92574; Q00994 transfection|expression level:Q92574 overexpressed|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2007/08/24	2014/10/16	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:vG0PO2+fbllJpBTuFohFVN9Ar8g9606	intact-crc:310971738F9B6A40|rigid:HzGugwaepfRrt8iW93VyekvFGPQ	false	green fluorescent protein tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P08138	uniprotkb:Q00994	intact:EBI-1387782|uniprotkb:B2R961|uniprotkb:B4E096|ensembl:ENSP00000172229	intact:EBI-741753|uniprotkb:Q5JQT4|uniprotkb:Q5JQT5|uniprotkb:B2RD17|uniprotkb:D3DXA3|ensembl:ENSP00000361718|ensembl:ENSP00000361728	psi-mi:tnr16_human(display_long)|uniprotkb:NGFR(gene name)|psi-mi:NGFR(display_short)|uniprotkb:TNFRSF16(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)|uniprotkb:Gp80-LNGFR(gene name synonym)|uniprotkb:p75 ICD(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)	psi-mi:bex3_human(display_long)|uniprotkb:BEX3(gene name)|psi-mi:BEX3(display_short)|uniprotkb:Brain-expressed X-linked protein 3(gene name synonym)|uniprotkb:DXS6984E(gene name synonym)|uniprotkb:NADE(gene name synonym)|uniprotkb:NGFRAP1(gene name synonym)|uniprotkb:Nerve growth factor receptor-associated protein 1(gene name synonym)|uniprotkb:Ovarian granulosa cell 13.0 kDa protein HGR74(gene name synonym)|uniprotkb:p75NTR-associated cell death executor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1387792|imex:IM-19197-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002498.1|dip:DIP-406N|ensembl:ENSG00000064300(gene)|ensembl:ENST00000172229(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005035"(death receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0021675"(nerve development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:P08138|rcsb pdb:2N80|rcsb pdb:2N83|rcsb pdb:2N97|rcsb pdb:3EWV|rcsb pdb:5ZGG|reactome:R-HSA-193634|reactome:R-HSA-193648|reactome:R-HSA-193670|reactome:R-HSA-193681|reactome:R-HSA-193692|reactome:R-HSA-205017|reactome:R-HSA-205025|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-209563	refseq:NP_055195.1|refseq:NP_996798.1|refseq:NP_996800.1|ensembl:ENSG00000166681(gene)|ensembl:ENST00000372635(transcript)|ensembl:ENST00000372645(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005163"(nerve growth factor receptor binding)|rcsb pdb:1SA6|reactome:R-HSA-205025|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007623(Brain expressed X-linked like protein)|interpro:IPR021156|mint:Q00994	-	-	-	figure legend:3 A|caution:Tuberin was also coimmunoprecipitated but a unique UniProtKB identifier could not be associated with this protein.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12h)|taxid:10116(Rattus norvegicus PC12h adrenal phaeochromocytoma cell line)	-	2007/08/24	2014/10/16	rogid:xoP55XGR3zC9f2ClOxgUWU3xnzk9606	rogid:vG0PO2+fbllJpBTuFohFVN9Ar8g9606	intact-crc:EDE81EFED87528DA|rigid:b4Hd4Yo97LYIVwFFFmClAAcSo7o	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P08138	uniprotkb:Q92574	intact:EBI-1387782|uniprotkb:B2R961|uniprotkb:B4E096|ensembl:ENSP00000172229	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:tnr16_human(display_long)|uniprotkb:NGFR(gene name)|psi-mi:NGFR(display_short)|uniprotkb:TNFRSF16(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)|uniprotkb:Gp80-LNGFR(gene name synonym)|uniprotkb:p75 ICD(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yasui et al. (2007)	pubmed:17355907|imex:IM-19197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1387792|imex:IM-19197-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002498.1|dip:DIP-406N|ensembl:ENSG00000064300(gene)|ensembl:ENST00000172229(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005035"(death receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0021675"(nerve development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:P08138|rcsb pdb:2N80|rcsb pdb:2N83|rcsb pdb:2N97|rcsb pdb:3EWV|rcsb pdb:5ZGG|reactome:R-HSA-193634|reactome:R-HSA-193648|reactome:R-HSA-193670|reactome:R-HSA-193681|reactome:R-HSA-193692|reactome:R-HSA-205017|reactome:R-HSA-205025|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-209563	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	-	-	-	figure legend:3 A|caution:Tuberin was also coimmunoprecipitated but a unique UniProtKB identifier could not be associated with this protein.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12h)|taxid:10116(Rattus norvegicus PC12h adrenal phaeochromocytoma cell line)	-	2007/08/24	2014/10/16	rogid:xoP55XGR3zC9f2ClOxgUWU3xnzk9606	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	intact-crc:EDE81EFED87528DA|rigid:b4Hd4Yo97LYIVwFFFmClAAcSo7o	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)