#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P18887	uniprotkb:Q8IW19	intact:EBI-947466|uniprotkb:Q9HCB1|uniprotkb:Q6IBS4|ensembl:ENSP00000262887	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	psi-mi:xrcc1_human(display_long)|uniprotkb:XRCC1(gene name)|psi-mi:XRCC1(display_short)|uniprotkb:X-ray repair cross-complementing protein 1(gene name synonym)	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Iles et al. (2007)	pubmed:17353262|imex:IM-19723	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1256053|imex:IM-19723-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006288.2|dip:DIP-39067N|ensembl:ENSG00000073050(gene)|ensembl:ENST00000262887(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010033"(response to organic substance)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0032356"(oxidized DNA binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904877"(positive regulation of DNA ligase activity)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990599"(3' overhang single-stranded DNA endodeoxyribonuclease activity)|interpro:IPR001357(BRCT)|interpro:IPR002706(DNA-repair protein Xrcc1, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036420|mint:P18887|rcsb pdb:1CDZ|rcsb pdb:1XNA|rcsb pdb:1XNT|rcsb pdb:2D8M|rcsb pdb:2W3O|rcsb pdb:3K75|rcsb pdb:3K77|rcsb pdb:3LQC|rcsb pdb:5E6Q|rcsb pdb:5W7X|rcsb pdb:5W7Y|reactome:R-HSA-110381|reactome:R-HSA-5649702|reactome:R-HSA-5685939|reactome:R-HSA-5696397|reactome:R-HSA-6782210	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ	-	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/05/30	2014/10/16	rogid:96hETrBzHYhHX9FC5dZpKnFcjDg9606	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	intact-crc:2C2721FBD0AD5A7C|rigid:0NPkIA/ltpJ3aJubYceZcyY7N6s	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13426	uniprotkb:Q8IW19	intact:EBI-717592|uniprotkb:Q9BS72|uniprotkb:Q9UP94|uniprotkb:A8K3X4|ensembl:ENSP00000342011|ensembl:ENSP00000421491	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	psi-mi:xrcc4_human(display_long)|uniprotkb:X-ray repair cross-complementing protein 4(gene name synonym)|uniprotkb:XRCC4(gene name)|psi-mi:XRCC4(display_short)	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Iles et al. (2007)	pubmed:17353262|imex:IM-19723	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1256058|imex:IM-19723-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003392.1|refseq:NP_071801.1|refseq:NP_072044.1|refseq:NP_001304941.1|refseq:NP_001304942.1|refseq:XP_011541928.1|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010165"(response to X-ray)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0070975"(FHA domain binding)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:1990166"(protein localization to site of double-strand break)|interpro:IPR009089(DNA double-strand break repair and VJ recombination XRCC4, N-terminal)|interpro:IPR010585(DNA double-strand break repair and VJ recombination XRCC4)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR038051|mint:Q13426|rcsb pdb:1FU1|rcsb pdb:1IK9|rcsb pdb:3II6|rcsb pdb:3MUD|rcsb pdb:3Q4F|rcsb pdb:3RWR|rcsb pdb:3SR2|go:"GO:0005737"(cytoplasm)|rcsb pdb:3W03|rcsb pdb:4XA4|rcsb pdb:5CHX|rcsb pdb:5CJ0|rcsb pdb:5CJ4|rcsb pdb:5E50|rcsb pdb:5WJ7|rcsb pdb:5WLZ|rcsb pdb:6ABO|rcsb pdb:7LSY|rcsb pdb:7LT3|rcsb pdb:7M3P|reactome:R-HSA-164843|reactome:R-HSA-3108214|reactome:R-HSA-5693571|ensembl:ENSG00000152422(gene)|ensembl:ENST00000338635(transcript)|ensembl:ENST00000511817(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|dip:DIP-37957N	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ	-	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/05/30	2014/10/16	rogid:qWdX2yBKXcwYG7vQpss9MIaFWU89606	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	intact-crc:83FBCE3A7CFFFDCF|rigid:/SsbF6pf0XdCflrJrKxJPBPoN+k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P18887	uniprotkb:Q8IW19	intact:EBI-947466|uniprotkb:Q9HCB1|uniprotkb:Q6IBS4|ensembl:ENSP00000262887	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	psi-mi:xrcc1_human(display_long)|uniprotkb:XRCC1(gene name)|psi-mi:XRCC1(display_short)|uniprotkb:X-ray repair cross-complementing protein 1(gene name synonym)	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Iles et al. (2007)	pubmed:17353262|imex:IM-19723	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1256069|imex:IM-19723-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006288.2|dip:DIP-39067N|ensembl:ENSG00000073050(gene)|ensembl:ENST00000262887(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010033"(response to organic substance)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0032356"(oxidized DNA binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904877"(positive regulation of DNA ligase activity)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990599"(3' overhang single-stranded DNA endodeoxyribonuclease activity)|interpro:IPR001357(BRCT)|interpro:IPR002706(DNA-repair protein Xrcc1, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036420|mint:P18887|rcsb pdb:1CDZ|rcsb pdb:1XNA|rcsb pdb:1XNT|rcsb pdb:2D8M|rcsb pdb:2W3O|rcsb pdb:3K75|rcsb pdb:3K77|rcsb pdb:3LQC|rcsb pdb:5E6Q|rcsb pdb:5W7X|rcsb pdb:5W7Y|reactome:R-HSA-110381|reactome:R-HSA-5649702|reactome:R-HSA-5685939|reactome:R-HSA-5696397|reactome:R-HSA-6782210	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ	-	-	-	figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/05/30	2014/10/16	rogid:96hETrBzHYhHX9FC5dZpKnFcjDg9606	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	intact-crc:03DC3A3959635AB9|rigid:0NPkIA/ltpJ3aJubYceZcyY7N6s	false	-	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IW19	uniprotkb:P18887	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	intact:EBI-947466|uniprotkb:Q9HCB1|uniprotkb:Q6IBS4|ensembl:ENSP00000262887	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:xrcc1_human(display_long)|uniprotkb:XRCC1(gene name)|psi-mi:XRCC1(display_short)|uniprotkb:X-ray repair cross-complementing protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Iles et al. (2007)	pubmed:17353262|imex:IM-19723	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1256104|imex:IM-19723-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ	refseq:NP_006288.2|dip:DIP-39067N|ensembl:ENSG00000073050(gene)|ensembl:ENST00000262887(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010033"(response to organic substance)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0032356"(oxidized DNA binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904877"(positive regulation of DNA ligase activity)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990599"(3' overhang single-stranded DNA endodeoxyribonuclease activity)|interpro:IPR001357(BRCT)|interpro:IPR002706(DNA-repair protein Xrcc1, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036420|mint:P18887|rcsb pdb:1CDZ|rcsb pdb:1XNA|rcsb pdb:1XNT|rcsb pdb:2D8M|rcsb pdb:2W3O|rcsb pdb:3K75|rcsb pdb:3K77|rcsb pdb:3LQC|rcsb pdb:5E6Q|rcsb pdb:5W7X|rcsb pdb:5W7Y|reactome:R-HSA-110381|reactome:R-HSA-5649702|reactome:R-HSA-5685939|reactome:R-HSA-5696397|reactome:R-HSA-6782210	-	-	-	figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a_549)|taxid:9606(Homo sapiens Caucasian lung carcinoma cell line)	-	2007/05/30	2014/10/16	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	rogid:96hETrBzHYhHX9FC5dZpKnFcjDg9606	intact-crc:1BF4CDC72604016A|rigid:0NPkIA/ltpJ3aJubYceZcyY7N6s	false	-	O-phospho-L-serine:485-485|O-phospho-L-threonine:488-488	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P18887	uniprotkb:Q8IW19	intact:EBI-947466|uniprotkb:Q9HCB1|uniprotkb:Q6IBS4|ensembl:ENSP00000262887	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	psi-mi:xrcc1_human(display_long)|uniprotkb:XRCC1(gene name)|psi-mi:XRCC1(display_short)|uniprotkb:X-ray repair cross-complementing protein 1(gene name synonym)	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Iles et al. (2007)	pubmed:17353262|imex:IM-19723	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1256184|imex:IM-19723-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006288.2|dip:DIP-39067N|ensembl:ENSG00000073050(gene)|ensembl:ENST00000262887(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010033"(response to organic substance)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0032356"(oxidized DNA binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904877"(positive regulation of DNA ligase activity)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990599"(3' overhang single-stranded DNA endodeoxyribonuclease activity)|interpro:IPR001357(BRCT)|interpro:IPR002706(DNA-repair protein Xrcc1, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036420|mint:P18887|rcsb pdb:1CDZ|rcsb pdb:1XNA|rcsb pdb:1XNT|rcsb pdb:2D8M|rcsb pdb:2W3O|rcsb pdb:3K75|rcsb pdb:3K77|rcsb pdb:3LQC|rcsb pdb:5E6Q|rcsb pdb:5W7X|rcsb pdb:5W7Y|reactome:R-HSA-110381|reactome:R-HSA-5649702|reactome:R-HSA-5685939|reactome:R-HSA-5696397|reactome:R-HSA-6782210	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ	-	-	-	figure legend:3B. 3C|caution:Ser-519 and Ser-523 described in the paper, actually appear to be threonine residues.|comment:APLF interacts with the phosphorylated form of XRCC1. The phosphorylated residues were first identified by incubating the XRCC1 with CK2 under the same conditions as used in this experiment and demonstrating site specific phosphorylation by use of the appropriate antibodies.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/05/30	2014/10/16	rogid:96hETrBzHYhHX9FC5dZpKnFcjDg9606	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	intact-crc:47CBE8689C4A1AF4|rigid:0NPkIA/ltpJ3aJubYceZcyY7N6s	false	O-phospho-L-serine:485-485|O-phospho-L-threonine:488-488|O-phospho-L-serine:518-518|O-phospho-L-threonine:519-519|O-phospho-L-threonine:523-523|his tag:?-?	sufficient binding region:1-166(IPR008984)|his tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8IW19	uniprotkb:P18887	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	intact:EBI-947466|uniprotkb:Q9HCB1|uniprotkb:Q6IBS4|ensembl:ENSP00000262887	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:xrcc1_human(display_long)|uniprotkb:XRCC1(gene name)|psi-mi:XRCC1(display_short)|uniprotkb:X-ray repair cross-complementing protein 1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Iles et al. (2007)	pubmed:17353262|imex:IM-19723	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1256324|imex:IM-19723-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ	refseq:NP_006288.2|dip:DIP-39067N|ensembl:ENSG00000073050(gene)|ensembl:ENST00000262887(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010033"(response to organic substance)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0032356"(oxidized DNA binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904877"(positive regulation of DNA ligase activity)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990599"(3' overhang single-stranded DNA endodeoxyribonuclease activity)|interpro:IPR001357(BRCT)|interpro:IPR002706(DNA-repair protein Xrcc1, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036420|mint:P18887|rcsb pdb:1CDZ|rcsb pdb:1XNA|rcsb pdb:1XNT|rcsb pdb:2D8M|rcsb pdb:2W3O|rcsb pdb:3K75|rcsb pdb:3K77|rcsb pdb:3LQC|rcsb pdb:5E6Q|rcsb pdb:5W7X|rcsb pdb:5W7Y|reactome:R-HSA-110381|reactome:R-HSA-5649702|reactome:R-HSA-5685939|reactome:R-HSA-5696397|reactome:R-HSA-6782210	-	-	-	figure legend:3D|caution:Ser-519 and Ser-523 described in the paper, actually appear to be threonine residues.|comment:APLF interacts with the phosphorylated form of XRCC1. The phosphorylated residues were first identified by incubating the XRCC1 with CK2 under the same conditions as used in this experiment and demonstrating site specific phosphorylation by use of the appropriate antibodies.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/05/30	2014/10/16	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	rogid:96hETrBzHYhHX9FC5dZpKnFcjDg9606	intact-crc:BF091A7107D89405|rigid:0NPkIA/ltpJ3aJubYceZcyY7N6s	false	sufficient binding region:1-166(IPR008984)|his tag:?-?	O-phospho-L-serine:485-485|O-phospho-L-threonine:488-488|O-phospho-L-serine:518-518|O-phospho-L-threonine:519-519|O-phospho-L-threonine:523-523|his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P18887	uniprotkb:Q8IW19	intact:EBI-947466|uniprotkb:Q9HCB1|uniprotkb:Q6IBS4|ensembl:ENSP00000262887	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	psi-mi:xrcc1_human(display_long)|uniprotkb:XRCC1(gene name)|psi-mi:XRCC1(display_short)|uniprotkb:X-ray repair cross-complementing protein 1(gene name synonym)	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Iles et al. (2007)	pubmed:17353262|imex:IM-19723	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1256372|imex:IM-19723-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006288.2|dip:DIP-39067N|ensembl:ENSG00000073050(gene)|ensembl:ENST00000262887(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010033"(response to organic substance)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0032356"(oxidized DNA binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904877"(positive regulation of DNA ligase activity)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990599"(3' overhang single-stranded DNA endodeoxyribonuclease activity)|interpro:IPR001357(BRCT)|interpro:IPR002706(DNA-repair protein Xrcc1, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036420|mint:P18887|rcsb pdb:1CDZ|rcsb pdb:1XNA|rcsb pdb:1XNT|rcsb pdb:2D8M|rcsb pdb:2W3O|rcsb pdb:3K75|rcsb pdb:3K77|rcsb pdb:3LQC|rcsb pdb:5E6Q|rcsb pdb:5W7X|rcsb pdb:5W7Y|reactome:R-HSA-110381|reactome:R-HSA-5649702|reactome:R-HSA-5685939|reactome:R-HSA-5696397|reactome:R-HSA-6782210	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ	go:"GO:0005634"(nucleus)|go:"GO:0009411"(response to UV)	-	-	figure legend:4A|agonist:0.35 uJ/um2 UVA|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a_549)|taxid:9606(Homo sapiens Caucasian lung carcinoma cell line)	-	2007/05/30	2014/10/16	rogid:96hETrBzHYhHX9FC5dZpKnFcjDg9606	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	intact-crc:9A06A57C39DEA6B1|rigid:0NPkIA/ltpJ3aJubYceZcyY7N6s	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q8IW19	uniprotkb:P18887	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	intact:EBI-947466|uniprotkb:Q9HCB1|uniprotkb:Q6IBS4|ensembl:ENSP00000262887	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:xrcc1_human(display_long)|uniprotkb:XRCC1(gene name)|psi-mi:XRCC1(display_short)|uniprotkb:X-ray repair cross-complementing protein 1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Iles et al. (2007)	pubmed:17353262|imex:IM-19723	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1256386|imex:IM-19723-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ	refseq:NP_006288.2|dip:DIP-39067N|ensembl:ENSG00000073050(gene)|ensembl:ENST00000262887(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010033"(response to organic substance)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0032356"(oxidized DNA binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904877"(positive regulation of DNA ligase activity)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990599"(3' overhang single-stranded DNA endodeoxyribonuclease activity)|interpro:IPR001357(BRCT)|interpro:IPR002706(DNA-repair protein Xrcc1, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036420|mint:P18887|rcsb pdb:1CDZ|rcsb pdb:1XNA|rcsb pdb:1XNT|rcsb pdb:2D8M|rcsb pdb:2W3O|rcsb pdb:3K75|rcsb pdb:3K77|rcsb pdb:3LQC|rcsb pdb:5E6Q|rcsb pdb:5W7X|rcsb pdb:5W7Y|reactome:R-HSA-110381|reactome:R-HSA-5649702|reactome:R-HSA-5685939|reactome:R-HSA-5696397|reactome:R-HSA-6782210	go:"GO:0005634"(nucleus)|go:"GO:0033194"(response to hydroperoxide)	-	-	figure legend:4C|agonist:10 mM H2O2 for 10 min|comment:Arg27Ala mutant of APLF remains in the cytoplasm after hydrogen peroxide treatment.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2007/05/30	2014/10/16	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	rogid:96hETrBzHYhHX9FC5dZpKnFcjDg9606	intact-crc:68A162E503501B3C|rigid:0NPkIA/ltpJ3aJubYceZcyY7N6s	false	yellow fluorescent protein tag:?-?|mutation:27-27	red fluorescent protein tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)