#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P70205	uniprotkb:Q60751	intact:EBI-7301045|intact:MINT-4544489|ensembl:ENSMUSP00000063784	intact:EBI-7300983|uniprotkb:Q62123|intact:MINT-219894|uniprotkb:O70438	psi-mi:pacr_mouse(display_long)|uniprotkb:Adcyap1r1(gene name)|psi-mi:Adcyap1r1(display_short)	psi-mi:igf1r_mouse(display_long)|uniprotkb:Igf1r(gene name)|psi-mi:Igf1r(display_short)|uniprotkb:Insulin-like growth factor I receptor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Delcourt et al. (2007)	pubmed:17332755|imex:IM-10881|mint:MINT-5219720	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7301082|mint:MINT-4544503|imex:IM-10881-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031433.3|ensembl:ENSMUSG00000029778(gene)|ensembl:ENSMUST00000070736(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004999"(vasoactive intestinal polypeptide receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR002285(GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|mint:P70205|reactome:R-MMU-418555|reactome:R-MMU-420092|mint:MINT-4544504(identity)	mint:Q60751|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR011009(Protein kinase-like)|refseq:NP_034643.2|interpro:IPR016246(Insulin receptor)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008544"(epidermis development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021549"(cerebellum development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030238"(male sex determination)|go:"GO:0030315"(T-tubule)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030879"(mammary gland development)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045471"(response to ethanol)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051054"(positive regulation of DNA metabolic process)|go:"GO:0051389"(obsolete inactivation of MAPKK activity)|go:"GO:0051446"(positive regulation of meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090031"(positive regulation of steroid hormone biosynthetic process)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140318"(protein transporter activity)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902911"(protein kinase complex)|go:"GO:1903944"(negative regulation of hepatocyte apoptotic process)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|rcsb pdb:6PYH|reactome:R-MMU-2404192|reactome:R-MMU-2428928|reactome:R-MMU-2428933|reactome:R-MMU-9009391|interpro:IPR036116|interpro:IPR036941|mint:MINT-4544505(identity)	-	comment:mint|function:This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract	function:"This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade"|comment:mint	figure legend:F4A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cerebral_cortical_neuron)|taxid:10090(Mouse cerebral cortical neuron)	-	2007/04/23	2014/10/16	rogid:15w4FgHKX0nNV/gO2iyayhkWQIQ10090	rogid:kaj4Hf4oZuTFc6TGuu9Doi84y5Y10090	intact-crc:9AD159DDFC1E2FF8|rigid:yoz33UH84jieupcD3+LgEMBeHks	false	tag:?-?(MINT-4544514)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0113"(western blot)