#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P50755	uniprotkb:Q91727	intact:EBI-7270567|intact:MINT-4507160	intact:EBI-7270544|intact:MINT-4507150	psi-mi:ccnd1_xenla(display_long)|uniprotkb:ccnd1(gene name)|psi-mi:ccnd1(display_short)	psi-mi:cdk4_xenla(display_long)|uniprotkb:cdk4(gene name)|psi-mi:cdk4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2007)	pubmed:17304238|imex:IM-10845|mint:MINT-5219648	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7270561|mint:MINT-4507173|imex:IM-10845-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P50755|interpro:IPR015451(Cyclin D)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR036915|interpro:IPR039361|mint:MINT-4507175(identity)	mint:Q91727|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_001079719.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0051301"(cell division)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|mint:MINT-4507174(identity)	-	comment:mint|function:"Essential for the control of the cell cycle at the G1/S (start) transition"	function:Probably involved in the control of the cell cycle|comment:mint	figure legend:F1B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2007/03/26	2014/10/16	rogid:FAiOYGB15w9CRzXIDWSsxWxnwtA8355	rogid:+Nyo3du4UcUiJgxaKeivw3tkyEg8355	intact-crc:23B3ED546546AD38|rigid:XQqtEjsIkqLfsnRA6C8TgHT2l2A	false	ha tag:?-?(MINT-4507182)	myc tag:?-?(MINT-4507176)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91727	uniprotkb:Q6GLD3	intact:EBI-7270544|intact:MINT-4507150	intact:EBI-7270670|intact:MINT-4507208|ensembl:ENSXETP00000103153	psi-mi:cdk4_xenla(display_long)|uniprotkb:cdk4(gene name)|psi-mi:cdk4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)	psi-mi:q6gld3_xentr(display_long)|uniprotkb:ccnd1(gene name)|psi-mi:ccnd1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2007)	pubmed:17304238|imex:IM-10845|mint:MINT-5219648	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8364(xentr)|taxid:8364("Xenopus tropicalis (Western clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7270664|mint:MINT-4507244|imex:IM-10845-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q91727|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_001079719.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0051301"(cell division)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|mint:MINT-4507251(identity)	refseq:NP_001005452.1|ensembl:ENSXETG00000045695(gene)|ensembl:ENSXETT00000110913(transcript)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR015451(Cyclin D)|interpro:IPR036915|interpro:IPR039361|mint:Q6GLD3|mint:MINT-4507245(identity)	-	function:Probably involved in the control of the cell cycle|comment:mint	comment:mint	figure legend:F1B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2007/03/26	2014/10/16	rogid:+Nyo3du4UcUiJgxaKeivw3tkyEg8355	rogid:XuoaE6OTPlDCj/mN/R1rHrtu9XE8364	intact-crc:AAF15FFAD64AB268|rigid:n4OhIKnIcOFetfQCesEkNJZ3KdA	false	myc tag:?-?(MINT-4507252)	ha tag:?-?(MINT-4507246)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6GLD3	uniprotkb:Q91727	intact:EBI-7270670|intact:MINT-4507208|ensembl:ENSXETP00000103153	intact:EBI-7270544|intact:MINT-4507150	psi-mi:q6gld3_xentr(display_long)|uniprotkb:ccnd1(gene name)|psi-mi:ccnd1(display_short)	psi-mi:cdk4_xenla(display_long)|uniprotkb:cdk4(gene name)|psi-mi:cdk4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2007)	pubmed:17304238|imex:IM-10845|mint:MINT-5219648	taxid:8364(xentr)|taxid:8364("Xenopus tropicalis (Western clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7270727|mint:MINT-4507192|imex:IM-10845-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005452.1|ensembl:ENSXETG00000045695(gene)|ensembl:ENSXETT00000110913(transcript)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR015451(Cyclin D)|interpro:IPR036915|interpro:IPR039361|mint:Q6GLD3|mint:MINT-4507193(identity)	mint:Q91727|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_001079719.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0051301"(cell division)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|mint:MINT-4507199(identity)	-	comment:mint	function:Probably involved in the control of the cell cycle|comment:mint	figure legend:F1B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-embryo)|taxid:8355(Xenopus laevis embryo)	-	2007/03/26	2014/10/16	rogid:XuoaE6OTPlDCj/mN/R1rHrtu9XE8364	rogid:+Nyo3du4UcUiJgxaKeivw3tkyEg8355	intact-crc:738A5B8ABBB70956|rigid:n4OhIKnIcOFetfQCesEkNJZ3KdA	false	ha tag:?-?(MINT-4507196)	myc tag:?-?(MINT-4507202)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P50755	uniprotkb:Q91727	intact:EBI-7270567|intact:MINT-4507160	intact:EBI-7270544|intact:MINT-4507150	psi-mi:ccnd1_xenla(display_long)|uniprotkb:ccnd1(gene name)|psi-mi:ccnd1(display_short)	psi-mi:cdk4_xenla(display_long)|uniprotkb:cdk4(gene name)|psi-mi:cdk4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2007)	pubmed:17304238|imex:IM-10845|mint:MINT-5219648	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7270761|mint:MINT-4507222|imex:IM-10845-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P50755|interpro:IPR015451(Cyclin D)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR036915|interpro:IPR039361|mint:MINT-4507223(identity)	mint:Q91727|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_001079719.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0051301"(cell division)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|mint:MINT-4507229(identity)	-	comment:mint|function:"Essential for the control of the cell cycle at the G1/S (start) transition"	function:Probably involved in the control of the cell cycle|comment:mint	figure legend:F1B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-embryo)|taxid:8355(Xenopus laevis embryo)	-	2007/03/26	2014/10/16	rogid:FAiOYGB15w9CRzXIDWSsxWxnwtA8355	rogid:+Nyo3du4UcUiJgxaKeivw3tkyEg8355	intact-crc:604664F5743D6DCD|rigid:XQqtEjsIkqLfsnRA6C8TgHT2l2A	false	ha tag:?-?(MINT-4507226)	myc tag:?-?(MINT-4507232)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)