#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P18851	uniprotkb:P32917	intact:EBI-7390|uniprotkb:D6W2R8|ensemblfungi:YOR212W	intact:EBI-18373|uniprotkb:D6VS89|ensemblfungi:YDR103W	psi-mi:gbb_yeast(display_long)|uniprotkb:YOR50-2(orf name)|uniprotkb:YOR212W(locus name)|uniprotkb:STE4(gene name)|psi-mi:STE4(display_short)	psi-mi:ste5_yeast(display_long)|uniprotkb:STE5(gene name)|psi-mi:STE5(display_short)|uniprotkb:NUL3(gene name synonym)|uniprotkb:YDR103W(locus name)|uniprotkb:YD8557.12(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Strickfaden et al. (2007)	imex:IM-11812|pubmed:17289571	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1219344|imex:IM-11812-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005738|refseq:NP_014855.3|mint:P18851|dip:DIP-954N|ensemblfungi:YOR212W(gene)|ensemblfungi:YOR212W_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005937"(mating projection)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010525"(regulation of transposition, RNA-mediated)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0043577"(chemotropism)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120171"(Cdc24p-Far1p-Gbetagamma complex)|go:"GO:1903260"(protein localization to mating projection tip)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|rcsb pdb:1SCG|reactome:R-SCE-6814122	refseq:NP_010388.1|sgd:S000002510|go:"GO:0010525"(regulation of transposition, RNA-mediated)|go:"GO:0019900"(kinase binding)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0070867"(mating projection tip membrane)|interpro:IPR021106|interpro:IPR021651|interpro:IPR038382|rcsb pdb:2KGN|rcsb pdb:2L4U|rcsb pdb:3FZE|rcsb pdb:4F2H|go:"GO:0005886"(plasma membrane)|ensemblfungi:YDR103W(gene)|ensemblfungi:YDR103W_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|dip:DIP-858N|mint:P32917	psi-mi:"MI:0469"(intact)	crc64:4B0E26040AAA83E5	crc64:0435BDA0196B2D6F	figure legend:3 D|comment:The Ste5-16E mutant can still bind to Ste4.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/03/26	2014/10/16	rogid:nDgadSWQPcmSvQlIEjpNHPl3Hjc559292	rogid:4AGoihw1xiRnhpu4/VuycJzCLaE559292	intact-crc:65AA4BC0A4C6D5CB|rigid:UCR03YFGyq6xGOlieNkwhdGZTCk	false	green fluorescent protein tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P00546	uniprotkb:P20438	intact:EBI-4253|uniprotkb:D6VQF5|ensemblfungi:YBR160W	intact:EBI-4483|uniprotkb:E9P938|uniprotkb:D6W3B5|ensemblfungi:YPL256C	psi-mi:cdk1_yeast(display_long)|uniprotkb:CDC28(gene name)|psi-mi:CDC28(display_short)|uniprotkb:CDK1(gene name synonym)|uniprotkb:HSL5(gene name synonym)|uniprotkb:SRM5(gene name synonym)|uniprotkb:YBR1211(orf name)|uniprotkb:YBR160W(locus name)|uniprotkb:Cell division control protein 28(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)	psi-mi:cg12_yeast(display_long)|uniprotkb:CLN2(gene name)|psi-mi:CLN2(display_short)|uniprotkb:YPL256C(locus name)	psi-mi:"MI:0424"(protein kinase assay)	Strickfaden et al. (2007)	imex:IM-11812|pubmed:17289571	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1219413|imex:IM-11812-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000364|refseq:NP_009718.3|dip:DIP-1039N|mint:P00546|ensemblfungi:YBR160W(gene)|ensemblfungi:YBR160W_mRNA(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007165"(signal transduction)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010568"(regulation of budding cell apical bud growth)|go:"GO:0010570"(regulation of filamentous growth)|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)|go:"GO:0010696"(positive regulation of mitotic spindle pole body separation)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030332"(cyclin binding)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042393"(histone binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0045875"(negative regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0051446"(positive regulation of meiotic cell cycle)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0060303"(regulation of nucleosome density)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901319"(positive regulation of trehalose catabolic process)|go:"GO:1902596"(negative regulation of DNA replication origin binding)|go:"GO:1902889"(protein localization to spindle microtubule)|go:"GO:1903500"(negative regulation of mitotic actomyosin contractile ring assembly)|go:"GO:1903827"|go:"GO:1904291"(positive regulation of mitotic DNA damage checkpoint)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990139"(protein localization to nuclear periphery)|go:"GO:1990758"(mitotic sister chromatid biorientation)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-68949|reactome:R-SCE-68962|reactome:R-SCE-69017|reactome:R-SCE-69202|reactome:R-SCE-69656	refseq:NP_015067.1|sgd:S000006177|dip:DIP-2270N|reactome:R-SCE-3214858|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69202|reactome:R-SCE-69231|reactome:R-SCE-69656|reactome:R-SCE-75815|reactome:R-SCE-8951664|reactome:R-SCE-983168|ensemblfungi:YPL256C(gene)|ensemblfungi:YPL256C_mRNA(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000321"(re-entry into mitotic cell cycle after pheromone arrest)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR014399(G1 cyclin, CLN1/CLN2/Puc1)|interpro:IPR036915|interpro:IPR039361	psi-mi:"MI:0469"(intact)	crc64:57A7A2B97A90DC6C	crc64:D6426B94E040E960	figure legend:5 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/03/26	2014/10/16	rogid:gYjsHsmOYQGGIVjiQ/ZH+BB9BCM559292	rogid:iJ+vDdbwApGApbN713jiPPFsY2o559292	intact-crc:1699F78D528B97E9|rigid:cs+zNbG6yujIIKZZ3P3feXaKqUU	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P00546	uniprotkb:P32917	intact:EBI-4253|uniprotkb:D6VQF5|ensemblfungi:YBR160W	intact:EBI-18373|uniprotkb:D6VS89|ensemblfungi:YDR103W	psi-mi:cdk1_yeast(display_long)|uniprotkb:CDC28(gene name)|psi-mi:CDC28(display_short)|uniprotkb:CDK1(gene name synonym)|uniprotkb:HSL5(gene name synonym)|uniprotkb:SRM5(gene name synonym)|uniprotkb:YBR1211(orf name)|uniprotkb:YBR160W(locus name)|uniprotkb:Cell division control protein 28(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)	psi-mi:ste5_yeast(display_long)|uniprotkb:STE5(gene name)|psi-mi:STE5(display_short)|uniprotkb:NUL3(gene name synonym)|uniprotkb:YDR103W(locus name)|uniprotkb:YD8557.12(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Strickfaden et al. (2007)	imex:IM-11812|pubmed:17289571	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1219413|imex:IM-11812-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000364|refseq:NP_009718.3|dip:DIP-1039N|mint:P00546|ensemblfungi:YBR160W(gene)|ensemblfungi:YBR160W_mRNA(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007165"(signal transduction)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010568"(regulation of budding cell apical bud growth)|go:"GO:0010570"(regulation of filamentous growth)|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)|go:"GO:0010696"(positive regulation of mitotic spindle pole body separation)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030332"(cyclin binding)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042393"(histone binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0045875"(negative regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0051446"(positive regulation of meiotic cell cycle)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0060303"(regulation of nucleosome density)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901319"(positive regulation of trehalose catabolic process)|go:"GO:1902596"(negative regulation of DNA replication origin binding)|go:"GO:1902889"(protein localization to spindle microtubule)|go:"GO:1903500"(negative regulation of mitotic actomyosin contractile ring assembly)|go:"GO:1903827"|go:"GO:1904291"(positive regulation of mitotic DNA damage checkpoint)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990139"(protein localization to nuclear periphery)|go:"GO:1990758"(mitotic sister chromatid biorientation)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-68949|reactome:R-SCE-68962|reactome:R-SCE-69017|reactome:R-SCE-69202|reactome:R-SCE-69656	refseq:NP_010388.1|sgd:S000002510|go:"GO:0010525"(regulation of transposition, RNA-mediated)|go:"GO:0019900"(kinase binding)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0070867"(mating projection tip membrane)|interpro:IPR021106|interpro:IPR021651|interpro:IPR038382|rcsb pdb:2KGN|rcsb pdb:2L4U|rcsb pdb:3FZE|rcsb pdb:4F2H|go:"GO:0005886"(plasma membrane)|ensemblfungi:YDR103W(gene)|ensemblfungi:YDR103W_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|dip:DIP-858N|mint:P32917	psi-mi:"MI:0469"(intact)	crc64:57A7A2B97A90DC6C	crc64:0435BDA0196B2D6F	figure legend:5 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/03/26	2014/10/16	rogid:gYjsHsmOYQGGIVjiQ/ZH+BB9BCM559292	rogid:4AGoihw1xiRnhpu4/VuycJzCLaE559292	intact-crc:1699F78D528B97E9|rigid:cs+zNbG6yujIIKZZ3P3feXaKqUU	false	-	mutation decreasing interaction:71-71,81-81,102-102,4-4,11-11,29-29,43-43,69-69|sufficient binding region:1-125|glutathione s tranferase tag:?-?|mutation decreasing interaction:11-11,4-4,29-29,43-43,69-69,71-71,81-81,102-102	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)