#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O17323 uniprotkb:Q21017 intact:EBI-7177989|ensemblmetazoa:C10E2.3a.1|intact:MINT-4299370|uniprotkb:Q400M0|uniprotkb:H1ZUW2 intact:EBI-2893174|ensemblmetazoa:F58H12.1.1 psi-mi:hda4_caeel(display_long)|uniprotkb:hda-4(gene name)|psi-mi:hda-4(display_short)|uniprotkb:hda-7(gene name synonym)|uniprotkb:C10E2.3(orf name)|uniprotkb:Histone deacetylase 7(gene name synonym)|uniprotkb:CeHDA-7(gene name synonym) psi-mi:kin29_caeel(display_long)|uniprotkb:kin-29(gene name)|psi-mi:kin-29(display_short)|uniprotkb:sma-11(gene name synonym)|uniprotkb:F58H12.1(orf name) psi-mi:"MI:0424"(protein kinase assay) van et al. (2007) pubmed:17170704|imex:IM-11404|mint:MINT-5219461 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-7177983|mint:MINT-4299384|imex:IM-11404-1 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:O17323|ensemblmetazoa:C10E2.3a.1(transcript)|ensemblmetazoa:WBGene00001837(gene)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016575"(histone deacetylation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045664"(regulation of neuron differentiation)|reactome:R-CEL-3108214|reactome:R-CEL-8951936|refseq:NP_001257279.1|wormbase:C10E2.3a|wormbase:C10E2.3b|refseq:NP_001257278.1|interpro:IPR023801|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR023696|interpro:IPR037138|mint:MINT-4299386(identity) ensemblmetazoa:F58H12.1.1(transcript)|ensemblmetazoa:WBGene00002210(gene)|go:"GO:0000003"(reproduction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009408"(response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040010"(positive regulation of growth rate)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0040024"(dauer larval development)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043053"(dauer entry)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046811"(histone deacetylase inhibitor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|refseq:NP_508493.1|wormbase:F58H12.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q21017|mint:MINT-4299385(identity) - comment:mint|function:"Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May be involved in muscle development" - figure legend:F3B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/02/14 2014/10/16 rogid:eI24GaCXkg9O8G4SPB4Ask2fTys6239 rogid:4s8NpYym05Ph9ZIhp8KT4hY1h2U6239 intact-crc:305CDEA7339ED69F|rigid:YzUteMa9Y7OLlCJp7t5bEQ0MpnE false glutathione s tranferase tag:?-?(MINT-4299390) green fluorescent protein tag:?-?(MINT-4299395) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)