#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q90Z80	uniprotkb:Q9I9K6	intact:EBI-7161111|intact:MINT-4051752	intact:EBI-959114	psi-mi:fbx5a_xenla(display_long)|uniprotkb:fbxo5-a(gene name)|psi-mi:fbxo5-a(display_short)|uniprotkb:Early mitotic inhibitor 1-A(gene name synonym)|uniprotkb:emi1-a(gene name synonym)	psi-mi:q9i9k6_xenla(display_long)|uniprotkb:pin1.L(gene name)|psi-mi:pin1.L(display_short)|uniprotkb:Pin1(gene name synonym)|uniprotkb:pin1(gene name synonym)|uniprotkb:XELAEV_18018988mg(orf name)	psi-mi:"MI:0096"(pull down)	Bernis et al. (2007)	pubmed:17159919|imex:IM-10815|mint:MINT-5219437	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7161130|mint:MINT-4052395|imex:IM-10815-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q90Z80|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0045841"(negative regulation of mitotic metaphase/anaphase transition)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106061"(negative regulation of exit from meiosis)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|refseq:NP_001082122.1|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR036047|interpro:IPR044064|mint:MINT-4052397(identity)	refseq:NP_001084236.1|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|dip:DIP-35667N|mint:Q9I9K6|mint:MINT-4052396(identity)	-	comment:mint|function:"Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators cdc20 and fzr1/cdh1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding"	-	figure legend:F2A|figure legend:F2C|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/01/19	2014/10/16	rogid:lOAy5EIn/FCJaGe6/ZHaoXbp+zk8355	rogid:+U9gyIQdDqGzHcjEw8wiytjTClM8355	intact-crc:8D353CBFA6277396|rigid:H0r0hhSJPkTaOMHSgJagnb8qJ6g	false	-	glutathione s tranferase tag:?-?(MINT-4052403)|binding-associated region:8-37(MINT-4052407)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q90Z80	uniprotkb:Q9I9K6	intact:EBI-7161111|intact:MINT-4051752	intact:EBI-959114	psi-mi:fbx5a_xenla(display_long)|uniprotkb:fbxo5-a(gene name)|psi-mi:fbxo5-a(display_short)|uniprotkb:Early mitotic inhibitor 1-A(gene name synonym)|uniprotkb:emi1-a(gene name synonym)	psi-mi:q9i9k6_xenla(display_long)|uniprotkb:pin1.L(gene name)|psi-mi:pin1.L(display_short)|uniprotkb:Pin1(gene name synonym)|uniprotkb:pin1(gene name synonym)|uniprotkb:XELAEV_18018988mg(orf name)	psi-mi:"MI:0096"(pull down)	Bernis et al. (2007)	pubmed:17159919|imex:IM-10815|mint:MINT-5219437	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7161170|mint:MINT-4052415|imex:IM-10815-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q90Z80|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0045841"(negative regulation of mitotic metaphase/anaphase transition)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106061"(negative regulation of exit from meiosis)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|refseq:NP_001082122.1|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR036047|interpro:IPR044064|mint:MINT-4052416(identity)	refseq:NP_001084236.1|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|dip:DIP-35667N|mint:Q9I9K6|mint:MINT-4052420(identity)	-	comment:mint|function:"Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators cdc20 and fzr1/cdh1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding"	-	figure legend:F2B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/01/19	2014/10/16	rogid:lOAy5EIn/FCJaGe6/ZHaoXbp+zk8355	rogid:+U9gyIQdDqGzHcjEw8wiytjTClM8355	intact-crc:C75F1DD267532757|rigid:H0r0hhSJPkTaOMHSgJagnb8qJ6g	false	mutation disrupting interaction:10-10(MINT-4052433)	glutathione s tranferase tag:?-?(MINT-4052425)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q90Z80	uniprotkb:P70032	intact:EBI-7161111|intact:MINT-4051752	intact:EBI-3511304|uniprotkb:Q7ZWQ6	psi-mi:fbx5a_xenla(display_long)|uniprotkb:fbxo5-a(gene name)|psi-mi:fbxo5-a(display_short)|uniprotkb:Early mitotic inhibitor 1-A(gene name synonym)|uniprotkb:emi1-a(gene name synonym)	psi-mi:plk1_xenla(display_long)|uniprotkb:plx1(gene name synonym)|uniprotkb:Plx1(gene name synonym)|uniprotkb:Polo-like kinase 1(gene name synonym)|uniprotkb:plk1(gene name)|psi-mi:plk1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bernis et al. (2007)	pubmed:17159919|imex:IM-10815|mint:MINT-5219437	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7161211|mint:MINT-4052465|imex:IM-10815-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q90Z80|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0045841"(negative regulation of mitotic metaphase/anaphase transition)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106061"(negative regulation of exit from meiosis)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|refseq:NP_001082122.1|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR036047|interpro:IPR044064|mint:MINT-4052466(identity)	mint:P70032|dip:DIP-42603N|refseq:NP_001080788.1|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051233"(spindle midzone)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR033702|interpro:IPR036947|mint:MINT-4052470(identity)	-	comment:mint|function:"Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators cdc20 and fzr1/cdh1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding"	-	figure legend:F3C|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/01/19	2014/10/16	rogid:lOAy5EIn/FCJaGe6/ZHaoXbp+zk8355	rogid:4gWZeyS6h0rrULNgKgIufsQ/bLM8355	intact-crc:8CBD37F8C0FD022D|rigid:hnMOIfM0KQgA1qFcONMy7RLiSzY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q90Z80	uniprotkb:P70032	intact:EBI-7161111|intact:MINT-4051752	intact:EBI-3511304|uniprotkb:Q7ZWQ6	psi-mi:fbx5a_xenla(display_long)|uniprotkb:fbxo5-a(gene name)|psi-mi:fbxo5-a(display_short)|uniprotkb:Early mitotic inhibitor 1-A(gene name synonym)|uniprotkb:emi1-a(gene name synonym)	psi-mi:plk1_xenla(display_long)|uniprotkb:plx1(gene name synonym)|uniprotkb:Plx1(gene name synonym)|uniprotkb:Polo-like kinase 1(gene name synonym)|uniprotkb:plk1(gene name)|psi-mi:plk1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bernis et al. (2007)	pubmed:17159919|imex:IM-10815|mint:MINT-5219437	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7161200|mint:MINT-4052437|imex:IM-10815-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q90Z80|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0045841"(negative regulation of mitotic metaphase/anaphase transition)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106061"(negative regulation of exit from meiosis)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|refseq:NP_001082122.1|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR036047|interpro:IPR044064|mint:MINT-4052443(identity)	mint:P70032|dip:DIP-42603N|refseq:NP_001080788.1|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051233"(spindle midzone)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR033702|interpro:IPR036947|mint:MINT-4052438(identity)	-	comment:mint|function:"Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators cdc20 and fzr1/cdh1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding"	-	figure legend:F3C|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/01/19	2014/10/16	rogid:lOAy5EIn/FCJaGe6/ZHaoXbp+zk8355	rogid:4gWZeyS6h0rrULNgKgIufsQ/bLM8355	intact-crc:8B341E4011D7F02A|rigid:hnMOIfM0KQgA1qFcONMy7RLiSzY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q91854	uniprotkb:Q90Z80	intact:EBI-7161238|uniprotkb:P70038|intact:MINT-4052492|uniprotkb:P70037|uniprotkb:Q6AX69	intact:EBI-7161111|intact:MINT-4051752	psi-mi:trcb_xenla(display_long)|uniprotkb:fbxw1(gene name)|psi-mi:fbxw1(display_short)|uniprotkb:btrcp(gene name synonym)|uniprotkb:Beta-transducin repeat-containing protein(gene name synonym)	psi-mi:fbx5a_xenla(display_long)|uniprotkb:fbxo5-a(gene name)|psi-mi:fbxo5-a(display_short)|uniprotkb:Early mitotic inhibitor 1-A(gene name synonym)|uniprotkb:emi1-a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bernis et al. (2007)	pubmed:17159919|imex:IM-10815|mint:MINT-5219437	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7161259|mint:MINT-4052477|imex:IM-10815-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q91854|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|refseq:NP_001081064.1|dip:DIP-44075N|mint:MINT-4052478(identity)	mint:Q90Z80|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0045841"(negative regulation of mitotic metaphase/anaphase transition)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106061"(negative regulation of exit from meiosis)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|refseq:NP_001082122.1|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR036047|interpro:IPR044064|mint:MINT-4052482(identity)	-	function:"Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. May participate in Wnt signaling"|comment:mint	comment:mint|function:"Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators cdc20 and fzr1/cdh1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding"	figure legend:F3D|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/01/19	2014/10/16	rogid:eP5NUmwrCCQ1+6TctS7yelagu8I8355	rogid:lOAy5EIn/FCJaGe6/ZHaoXbp+zk8355	intact-crc:2CCD96F1517692EB|rigid:X1KOOx5+/1MIVGrTyBLMMXeroeA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q90Z80	uniprotkb:Q9I9K6	intact:EBI-7161111|intact:MINT-4051752	intact:EBI-959114	psi-mi:fbx5a_xenla(display_long)|uniprotkb:fbxo5-a(gene name)|psi-mi:fbxo5-a(display_short)|uniprotkb:Early mitotic inhibitor 1-A(gene name synonym)|uniprotkb:emi1-a(gene name synonym)	psi-mi:q9i9k6_xenla(display_long)|uniprotkb:pin1.L(gene name)|psi-mi:pin1.L(display_short)|uniprotkb:Pin1(gene name synonym)|uniprotkb:pin1(gene name synonym)|uniprotkb:XELAEV_18018988mg(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bernis et al. (2007)	pubmed:17159919|imex:IM-10815|mint:MINT-5219437	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7161281|mint:MINT-4052510|imex:IM-10815-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q90Z80|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0045841"(negative regulation of mitotic metaphase/anaphase transition)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106061"(negative regulation of exit from meiosis)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|refseq:NP_001082122.1|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR036047|interpro:IPR044064|mint:MINT-4052515(identity)	refseq:NP_001084236.1|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|dip:DIP-35667N|mint:Q9I9K6|mint:MINT-4052511(identity)	-	comment:mint|function:"Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators cdc20 and fzr1/cdh1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding"	-	figure legend:F5A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-xl2)|taxid:8355(Xenopus laevis tadpole cell line XL2)	-	2007/01/19	2014/10/16	rogid:lOAy5EIn/FCJaGe6/ZHaoXbp+zk8355	rogid:+U9gyIQdDqGzHcjEw8wiytjTClM8355	intact-crc:81D3B26071F454F9|rigid:H0r0hhSJPkTaOMHSgJagnb8qJ6g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)