#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O00512 uniprotkb:Q02248 intact:EBI-533127|uniprotkb:Q5T489|intact:EBI-28969406|ensembl:ENSP00000234739 intact:EBI-397872|ensembl:ENSMUSP00000007130|ensembl:ENSMUSP00000136294|uniprotkb:Q922W1|uniprotkb:Q9D335 psi-mi:bcl9_human(display_long)|uniprotkb:Protein legless homolog(gene name synonym)|uniprotkb:BCL9(gene name)|psi-mi:BCL9(display_short) psi-mi:ctnb1_mouse(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:Ctnnb1(gene name)|psi-mi:Ctnnb1(display_short)|uniprotkb:Catnb(gene name synonym) psi-mi:"MI:0018"(two hybrid) Hoffmans et al. (2007) pubmed:17113272|imex:IM-19196 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1385611|imex:IM-19196-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000234739|ensembl:ENSG00000116128(gene)|ensembl:ENST00000234739(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0014908"(myotube differentiation involved in skeletal muscle regeneration)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015668(B Cell Lymphoma 9)|interpro:IPR024670|mint:O00512|rcsb pdb:2GL7|rcsb pdb:2VP7|rcsb pdb:2VPB|rcsb pdb:2VPD|rcsb pdb:2VPE|rcsb pdb:2VPG|rcsb pdb:3SL9|reactome:R-HSA-201722|reactome:R-HSA-3769402|refseq:NP_004317.2|refseq:XP_005273028.1 go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048513"(animal organ development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|refseq:NP_001159374.1|refseq:NP_031640.1|ensembl:ENSMUSG00000006932(gene)|ensembl:ENSMUST00000007130(transcript)|ensembl:ENSMUST00000178812(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001709"(cell fate determination)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001840"(neural plate development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007507"(heart development)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009987"(cellular process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022405"(hair cycle process)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043296"(apical junction complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044093"(positive regulation of molecular function)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|dip:DIP-31560N|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0060983"(epicardium-derived cardiac vascular smooth muscle cell differentiation)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072132"(mesenchyme morphogenesis)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904796"(regulation of core promoter binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:Q02248|rcsb pdb:1DOW|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1JPP|rcsb pdb:1M1E|rcsb pdb:1V18|rcsb pdb:2BCT|rcsb pdb:3BCT|rcsb pdb:3OUW|rcsb pdb:3OUX|rcsb pdb:4EV8|rcsb pdb:4EV9|rcsb pdb:4EVA|rcsb pdb:4EVP|rcsb pdb:4EVT|rcsb pdb:4ONS|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-201722|reactome:R-MMU-3134973|reactome:R-MMU-351906|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-418990|reactome:R-MMU-4641262|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467|reactome:R-MMU-8853884|reactome:R-MMU-8951430 - - - figure legend:1 A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2007/08/21 2014/10/16 rogid:RCCh4ZkVE2BITRjPSL38IKnaaAk9606 rogid:xvyhb43JmWo6JgTE/YnFdAgvRlU10090 intact-crc:A294EAC84C8E448E|rigid:0z3x0FaCTXWTtNCS+vWlGLKEf20 false - mutation disrupting interaction:164-164 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86UU0 uniprotkb:Q02248 intact:EBI-1385618|uniprotkb:A1A4C1|uniprotkb:Q6ZWJ0|uniprotkb:Q6ZWK2|uniprotkb:Q67FY1|ensembl:ENSP00000335320|ensembl:ENSP00000507778 intact:EBI-397872|ensembl:ENSMUSP00000007130|ensembl:ENSMUSP00000136294|uniprotkb:Q922W1|uniprotkb:Q9D335 psi-mi:bcl9l_human(display_long)|uniprotkb:BCL9L(gene name)|psi-mi:BCL9L(display_short)|uniprotkb:DLNB11(gene name synonym)|uniprotkb:Protein BCL9-2(gene name synonym) psi-mi:ctnb1_mouse(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:Ctnnb1(gene name)|psi-mi:Ctnnb1(display_short)|uniprotkb:Catnb(gene name synonym) psi-mi:"MI:0018"(two hybrid) Hoffmans et al. (2007) pubmed:17113272|imex:IM-19196 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1385624|imex:IM-19196-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006718878.1|refseq:NP_872363.1|refseq:XP_005271568.1|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015668(B Cell Lymphoma 9)|interpro:IPR024670|mint:Q86UU0|rcsb pdb:2XB1|rcsb pdb:4UP0|rcsb pdb:4UP5|reactome:R-HSA-201722|reactome:R-HSA-3769402|ensembl:ENSG00000186174(gene)|ensembl:ENST00000334801(transcript)|ensembl:ENST00000683865(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0008013"(beta-catenin binding) go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048513"(animal organ development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|refseq:NP_001159374.1|refseq:NP_031640.1|ensembl:ENSMUSG00000006932(gene)|ensembl:ENSMUST00000007130(transcript)|ensembl:ENSMUST00000178812(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001709"(cell fate determination)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001840"(neural plate development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007507"(heart development)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009987"(cellular process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022405"(hair cycle process)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043296"(apical junction complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044093"(positive regulation of molecular function)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|dip:DIP-31560N|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0060983"(epicardium-derived cardiac vascular smooth muscle cell differentiation)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072132"(mesenchyme morphogenesis)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904796"(regulation of core promoter binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:Q02248|rcsb pdb:1DOW|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1JPP|rcsb pdb:1M1E|rcsb pdb:1V18|rcsb pdb:2BCT|rcsb pdb:3BCT|rcsb pdb:3OUW|rcsb pdb:3OUX|rcsb pdb:4EV8|rcsb pdb:4EV9|rcsb pdb:4EVA|rcsb pdb:4EVP|rcsb pdb:4EVT|rcsb pdb:4ONS|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-201722|reactome:R-MMU-3134973|reactome:R-MMU-351906|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-418990|reactome:R-MMU-4641262|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467|reactome:R-MMU-8853884|reactome:R-MMU-8951430 - - - figure legend:1 A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2007/08/21 2014/10/16 rogid:P+OLquMM+rYlekJdbUA4BuFP5xs9606 rogid:xvyhb43JmWo6JgTE/YnFdAgvRlU10090 intact-crc:9FA53DAE22D7C973|rigid:stL6q8WnBTGrkqtP6iOohHrHcCM false - mutation disrupting interaction:164-164 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P18824 uniprotkb:Q961D9 intact:EBI-216128|uniprotkb:A4V3V0|uniprotkb:O02371|uniprotkb:Q0KHX2|uniprotkb:Q8IRW7|uniprotkb:Q9W546|ensemblmetazoa:FBpp0089031|ensemblmetazoa:FBpp0089032|ensemblmetazoa:FBpp0089034|ensemblmetazoa:FBpp0089035|ensemblmetazoa:FBpp0304835 intact:EBI-85519|uniprotkb:Q9V4D2|ensemblmetazoa:FBpp0088180 psi-mi:arm_drome(display_long)|uniprotkb:arm(gene name)|psi-mi:arm(display_short)|uniprotkb:CG11579(orf name) psi-mi:bcl9_drome(display_long)|uniprotkb:lgs(gene name)|psi-mi:lgs(display_short)|uniprotkb:BCL9(gene name synonym)|uniprotkb:CG2041(orf name)|uniprotkb:Protein legless(gene name synonym) psi-mi:"MI:0018"(two hybrid) Hoffmans et al. (2007) pubmed:17113272|imex:IM-19196 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1385646|imex:IM-19196-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_476665.2|refseq:NP_476666.1|refseq:NP_599100.1|refseq:NP_726775.2|refseq:NP_996328.1|flybase:FBgn0000117|refseq:NP_001259149.1|dip:DIP-19968N|ensemblmetazoa:FBgn0000117(gene)|ensemblmetazoa:FBtr0089988(transcript)|ensemblmetazoa:FBtr0089989(transcript)|ensemblmetazoa:FBtr0089991(transcript)|ensemblmetazoa:FBtr0089992(transcript)|ensemblmetazoa:FBtr0332583(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007370"(ventral furrow formation)|go:"GO:0007391"(dorsal closure)|go:"GO:0007399"(nervous system development)|go:"GO:0007472"(wing disc morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0007616"(long-term memory)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0014017"(neuroblast fate commitment)|go:"GO:0014019"(neuroblast development)|go:"GO:0016028"(rhabdomere)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035147"(branch fusion, open tracheal system)|go:"GO:0035153"(epithelial cell type specification, open tracheal system)|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0048477"(oogenesis)|go:"GO:0048526"(imaginal disc-derived wing expansion)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060232"(delamination)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060914"(heart formation)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090254"(cell elongation involved in imaginal disc-derived wing morphogenesis)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P18824|reactome:R-DME-195253|reactome:R-DME-196299|reactome:R-DME-201681|reactome:R-DME-201722|reactome:R-DME-209214|reactome:R-DME-209360|reactome:R-DME-209396|reactome:R-DME-209407|reactome:R-DME-209413|reactome:R-DME-209421|reactome:R-DME-209440|reactome:R-DME-209461|reactome:R-DME-3134973|reactome:R-DME-351906|reactome:R-DME-3769402|reactome:R-DME-4086398|reactome:R-DME-418990|reactome:R-DME-5218920|reactome:R-DME-525793|reactome:R-DME-6798695|reactome:R-DME-8853884|reactome:R-DME-8951430|reactome:R-DME-8980692|reactome:R-DME-9013406|reactome:R-DME-9013407 refseq:NP_651922.1|flybase:FBgn0039907|ensemblmetazoa:FBgn0039907(gene)|ensemblmetazoa:FBtr0089111(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007491"(sternite morphogenesis)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0035223"(leg disc pattern formation)|rcsb pdb:3ZPV|reactome:R-DME-201722|reactome:R-DME-209407|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|reactome:R-DME-209421|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR024670|dip:DIP-33392N - - - figure legend:1 B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2007/08/21 2014/10/16 rogid:ICcnVEVmwr7VAp5+5AATqvGwM4k7227 rogid:W5+IVXO6J6D9E9N7P5R6tFQ7bpc7227 intact-crc:82EAFEFDDEDC685A|rigid:dND5TwXtBut8BEt9xmrTFagEzcc false sufficient binding region:38-806|mutation disrupting interaction:172-172 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P18824 uniprotkb:P35220 intact:EBI-216128|uniprotkb:A4V3V0|uniprotkb:O02371|uniprotkb:Q0KHX2|uniprotkb:Q8IRW7|uniprotkb:Q9W546|ensemblmetazoa:FBpp0089031|ensemblmetazoa:FBpp0089032|ensemblmetazoa:FBpp0089034|ensemblmetazoa:FBpp0089035|ensemblmetazoa:FBpp0304835 intact:EBI-126806|uniprotkb:Q960Y2|uniprotkb:Q9W5V9|ensemblmetazoa:FBpp0070037 psi-mi:arm_drome(display_long)|uniprotkb:arm(gene name)|psi-mi:arm(display_short)|uniprotkb:CG11579(orf name) psi-mi:ctna_drome(display_long)|uniprotkb:alpha-Cat(gene name)|psi-mi:alpha-Cat(display_short)|uniprotkb:CG17947(orf name) psi-mi:"MI:0018"(two hybrid) Hoffmans et al. (2007) pubmed:17113272|imex:IM-19196 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1385654|imex:IM-19196-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_476665.2|refseq:NP_476666.1|refseq:NP_599100.1|refseq:NP_726775.2|refseq:NP_996328.1|flybase:FBgn0000117|refseq:NP_001259149.1|dip:DIP-19968N|ensemblmetazoa:FBgn0000117(gene)|ensemblmetazoa:FBtr0089988(transcript)|ensemblmetazoa:FBtr0089989(transcript)|ensemblmetazoa:FBtr0089991(transcript)|ensemblmetazoa:FBtr0089992(transcript)|ensemblmetazoa:FBtr0332583(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007370"(ventral furrow formation)|go:"GO:0007391"(dorsal closure)|go:"GO:0007399"(nervous system development)|go:"GO:0007472"(wing disc morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0007616"(long-term memory)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0014017"(neuroblast fate commitment)|go:"GO:0014019"(neuroblast development)|go:"GO:0016028"(rhabdomere)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035147"(branch fusion, open tracheal system)|go:"GO:0035153"(epithelial cell type specification, open tracheal system)|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0048477"(oogenesis)|go:"GO:0048526"(imaginal disc-derived wing expansion)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060232"(delamination)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060914"(heart formation)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090254"(cell elongation involved in imaginal disc-derived wing morphogenesis)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P18824|reactome:R-DME-195253|reactome:R-DME-196299|reactome:R-DME-201681|reactome:R-DME-201722|reactome:R-DME-209214|reactome:R-DME-209360|reactome:R-DME-209396|reactome:R-DME-209407|reactome:R-DME-209413|reactome:R-DME-209421|reactome:R-DME-209440|reactome:R-DME-209461|reactome:R-DME-3134973|reactome:R-DME-351906|reactome:R-DME-3769402|reactome:R-DME-4086398|reactome:R-DME-418990|reactome:R-DME-5218920|reactome:R-DME-525793|reactome:R-DME-6798695|reactome:R-DME-8853884|reactome:R-DME-8951430|reactome:R-DME-8980692|reactome:R-DME-9013406|reactome:R-DME-9013407 ensemblmetazoa:FBgn0010215(gene)|ensemblmetazoa:FBtr0070038(transcript)|go:"GO:0003383"(apical constriction)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046664"(dorsal closure, amnioserosa morphology change)|go:"GO:0051015"(actin filament binding)|go:"GO:0060323"(head morphogenesis)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR036723|reactome:R-DME-418990|reactome:R-DME-5218920|reactome:R-DME-525793|refseq:NP_524219.1|flybase:FBgn0010215|dip:DIP-21662N - - - figure legend:1 B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2007/08/21 2014/10/16 rogid:ICcnVEVmwr7VAp5+5AATqvGwM4k7227 rogid:W6XeVS/IvxqgE0UQ/SyWnAmiJo87227 intact-crc:15CC39D75777EA53|rigid:znIt5ScdiMpbU67N9XG7mqiTP5g false sufficient binding region:38-806|mutation disrupting interaction:150-150 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O00512 uniprotkb:P18824 intact:EBI-533127|uniprotkb:Q5T489|intact:EBI-28969406|ensembl:ENSP00000234739 intact:EBI-216128|uniprotkb:A4V3V0|uniprotkb:O02371|uniprotkb:Q0KHX2|uniprotkb:Q8IRW7|uniprotkb:Q9W546|ensemblmetazoa:FBpp0089031|ensemblmetazoa:FBpp0089032|ensemblmetazoa:FBpp0089034|ensemblmetazoa:FBpp0089035|ensemblmetazoa:FBpp0304835 psi-mi:bcl9_human(display_long)|uniprotkb:Protein legless homolog(gene name synonym)|uniprotkb:BCL9(gene name)|psi-mi:BCL9(display_short) psi-mi:arm_drome(display_long)|uniprotkb:arm(gene name)|psi-mi:arm(display_short)|uniprotkb:CG11579(orf name) psi-mi:"MI:0018"(two hybrid) Hoffmans et al. (2007) pubmed:17113272|imex:IM-19196 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1385676|imex:IM-19196-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000234739|ensembl:ENSG00000116128(gene)|ensembl:ENST00000234739(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0014908"(myotube differentiation involved in skeletal muscle regeneration)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015668(B Cell Lymphoma 9)|interpro:IPR024670|mint:O00512|rcsb pdb:2GL7|rcsb pdb:2VP7|rcsb pdb:2VPB|rcsb pdb:2VPD|rcsb pdb:2VPE|rcsb pdb:2VPG|rcsb pdb:3SL9|reactome:R-HSA-201722|reactome:R-HSA-3769402|refseq:NP_004317.2|refseq:XP_005273028.1 refseq:NP_476665.2|refseq:NP_476666.1|refseq:NP_599100.1|refseq:NP_726775.2|refseq:NP_996328.1|flybase:FBgn0000117|refseq:NP_001259149.1|dip:DIP-19968N|ensemblmetazoa:FBgn0000117(gene)|ensemblmetazoa:FBtr0089988(transcript)|ensemblmetazoa:FBtr0089989(transcript)|ensemblmetazoa:FBtr0089991(transcript)|ensemblmetazoa:FBtr0089992(transcript)|ensemblmetazoa:FBtr0332583(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007370"(ventral furrow formation)|go:"GO:0007391"(dorsal closure)|go:"GO:0007399"(nervous system development)|go:"GO:0007472"(wing disc morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0007616"(long-term memory)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0014017"(neuroblast fate commitment)|go:"GO:0014019"(neuroblast development)|go:"GO:0016028"(rhabdomere)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035147"(branch fusion, open tracheal system)|go:"GO:0035153"(epithelial cell type specification, open tracheal system)|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0048477"(oogenesis)|go:"GO:0048526"(imaginal disc-derived wing expansion)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060232"(delamination)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060914"(heart formation)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090254"(cell elongation involved in imaginal disc-derived wing morphogenesis)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P18824|reactome:R-DME-195253|reactome:R-DME-196299|reactome:R-DME-201681|reactome:R-DME-201722|reactome:R-DME-209214|reactome:R-DME-209360|reactome:R-DME-209396|reactome:R-DME-209407|reactome:R-DME-209413|reactome:R-DME-209421|reactome:R-DME-209440|reactome:R-DME-209461|reactome:R-DME-3134973|reactome:R-DME-351906|reactome:R-DME-3769402|reactome:R-DME-4086398|reactome:R-DME-418990|reactome:R-DME-5218920|reactome:R-DME-525793|reactome:R-DME-6798695|reactome:R-DME-8853884|reactome:R-DME-8951430|reactome:R-DME-8980692|reactome:R-DME-9013406|reactome:R-DME-9013407 - - - figure legend:1 B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2007/08/21 2014/10/16 rogid:RCCh4ZkVE2BITRjPSL38IKnaaAk9606 rogid:ICcnVEVmwr7VAp5+5AATqvGwM4k7227 intact-crc:2DFD7B4C8A9B0250|rigid:TslknEBIgIlQ7loHnjQa9Kv0+iU false - sufficient binding region:38-806 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P18824 uniprotkb:P91943 intact:EBI-216128|uniprotkb:A4V3V0|uniprotkb:O02371|uniprotkb:Q0KHX2|uniprotkb:Q8IRW7|uniprotkb:Q9W546|ensemblmetazoa:FBpp0089031|ensemblmetazoa:FBpp0089032|ensemblmetazoa:FBpp0089034|ensemblmetazoa:FBpp0089035|ensemblmetazoa:FBpp0304835 intact:EBI-147301|uniprotkb:O02548|uniprotkb:Q0KIE9|intact:EBI-1629313|uniprotkb:Q59DP5|uniprotkb:Q5BHZ3|uniprotkb:Q6W492|uniprotkb:Q6W493|uniprotkb:Q6W494|uniprotkb:Q6W495|uniprotkb:Q6W4A6|uniprotkb:Q6W4B4|uniprotkb:Q9V4B0|uniprotkb:A0AVW4|uniprotkb:A4V148|uniprotkb:B5RJS3|ensemblmetazoa:FBpp0088226|ensemblmetazoa:FBpp0088228|ensemblmetazoa:FBpp0088229|ensemblmetazoa:FBpp0301556 psi-mi:arm_drome(display_long)|uniprotkb:arm(gene name)|psi-mi:arm(display_short)|uniprotkb:CG11579(orf name) psi-mi:pang1_drome(display_long)|uniprotkb:pan(gene name)|psi-mi:pan(display_short)|uniprotkb:TCF(gene name synonym)|uniprotkb:dTCF(gene name synonym)|uniprotkb:CG34403(orf name) psi-mi:"MI:0018"(two hybrid) Hoffmans et al. (2007) pubmed:17113272|imex:IM-19196 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1385718|imex:IM-19196-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_476665.2|refseq:NP_476666.1|refseq:NP_599100.1|refseq:NP_726775.2|refseq:NP_996328.1|flybase:FBgn0000117|refseq:NP_001259149.1|dip:DIP-19968N|ensemblmetazoa:FBgn0000117(gene)|ensemblmetazoa:FBtr0089988(transcript)|ensemblmetazoa:FBtr0089989(transcript)|ensemblmetazoa:FBtr0089991(transcript)|ensemblmetazoa:FBtr0089992(transcript)|ensemblmetazoa:FBtr0332583(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007370"(ventral furrow formation)|go:"GO:0007391"(dorsal closure)|go:"GO:0007399"(nervous system development)|go:"GO:0007472"(wing disc morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0007616"(long-term memory)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0014017"(neuroblast fate commitment)|go:"GO:0014019"(neuroblast development)|go:"GO:0016028"(rhabdomere)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035147"(branch fusion, open tracheal system)|go:"GO:0035153"(epithelial cell type specification, open tracheal system)|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0048477"(oogenesis)|go:"GO:0048526"(imaginal disc-derived wing expansion)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060232"(delamination)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060914"(heart formation)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090254"(cell elongation involved in imaginal disc-derived wing morphogenesis)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P18824|reactome:R-DME-195253|reactome:R-DME-196299|reactome:R-DME-201681|reactome:R-DME-201722|reactome:R-DME-209214|reactome:R-DME-209360|reactome:R-DME-209396|reactome:R-DME-209407|reactome:R-DME-209413|reactome:R-DME-209421|reactome:R-DME-209440|reactome:R-DME-209461|reactome:R-DME-3134973|reactome:R-DME-351906|reactome:R-DME-3769402|reactome:R-DME-4086398|reactome:R-DME-418990|reactome:R-DME-5218920|reactome:R-DME-525793|reactome:R-DME-6798695|reactome:R-DME-8853884|reactome:R-DME-8951430|reactome:R-DME-8980692|reactome:R-DME-9013406|reactome:R-DME-9013407 refseq:NP_001245406.1|refseq:NP_001014685.1|refseq:NP_001033798.1|refseq:NP_524619.3|refseq:NP_726522.1|refseq:NP_726524.1|flybase:FBgn0085432|refseq:NP_726527.2|dip:DIP-19970N|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007500"(mesodermal cell fate determination)|go:"GO:0007507"(heart development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR013558(CTNNB1 binding, N-teminal)|interpro:IPR024940|interpro:IPR027397|interpro:IPR028782|interpro:IPR036910|reactome:R-DME-209421|reactome:R-DME-209441|ensemblmetazoa:FBgn0085432(gene)|ensemblmetazoa:FBtr0089159(transcript)|ensemblmetazoa:FBtr0089161(transcript)|ensemblmetazoa:FBtr0089162(transcript)|ensemblmetazoa:FBtr0309803(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific) - - - figure legend:1 B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2007/08/21 2014/10/16 rogid:ICcnVEVmwr7VAp5+5AATqvGwM4k7227 rogid:H6BhYVP6spDgW8etHP7+/L29jO87227 intact-crc:6EF299365E729F03|rigid:PMFzEaLzg6nhe4n96nqR93EGEDs false sufficient binding region:38-806|mutation disrupting interaction:172-172 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BRQ0 uniprotkb:O00512 intact:EBI-932471|uniprotkb:Q8WYZ4|uniprotkb:Q96CY2|intact:EBI-28967415|ensembl:ENSP00000357442 intact:EBI-533127|uniprotkb:Q5T489|intact:EBI-28969406|ensembl:ENSP00000234739 psi-mi:pygo2_human(display_long)|uniprotkb:PYGO2(gene name)|psi-mi:PYGO2(display_short)|uniprotkb:PP7910(orf name) psi-mi:bcl9_human(display_long)|uniprotkb:Protein legless homolog(gene name synonym)|uniprotkb:BCL9(gene name)|psi-mi:BCL9(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Hoffmans et al. (2007) pubmed:17113272|imex:IM-19196 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1385734|imex:IM-19196-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000357442|refseq:NP_612157.1|ensembl:ENSG00000163348(gene)|ensembl:ENST00000368457(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0007420"(brain development)|go:"GO:0030879"(mammary gland development)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0035034"(histone acetyltransferase regulator activity)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048589"(developmental growth)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|mint:Q9BRQ0|rcsb pdb:2XB1|rcsb pdb:4UP0|rcsb pdb:4UP5|reactome:R-HSA-201722|reactome:R-HSA-3769402 ensembl:ENSP00000234739|ensembl:ENSG00000116128(gene)|ensembl:ENST00000234739(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0014908"(myotube differentiation involved in skeletal muscle regeneration)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015668(B Cell Lymphoma 9)|interpro:IPR024670|mint:O00512|rcsb pdb:2GL7|rcsb pdb:2VP7|rcsb pdb:2VPB|rcsb pdb:2VPD|rcsb pdb:2VPE|rcsb pdb:2VPG|rcsb pdb:3SL9|reactome:R-HSA-201722|reactome:R-HSA-3769402|refseq:NP_004317.2|refseq:XP_005273028.1 - - - figure legend:5 B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2007/08/21 2014/10/16 rogid:pnjkTQxG5O0yk8WfuSd0MMsZ3dU9606 rogid:RCCh4ZkVE2BITRjPSL38IKnaaAk9606 intact-crc:1A3E30B0113E9F3D|rigid:jn71XmW6j/eqveJ0sWKgiD93UoY false ha tag:?-? flag tag:?-?|necessary binding region:387-530 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O00512 uniprotkb:Q6P1J9 intact:EBI-533127|uniprotkb:Q5T489|intact:EBI-28969406|ensembl:ENSP00000234739 intact:EBI-930143|uniprotkb:A6NLZ8|uniprotkb:Q6PK51|uniprotkb:Q96A07|uniprotkb:Q9H245|uniprotkb:Q9H5L7|uniprotkb:B2RBR2|ensembl:ENSP00000356405 psi-mi:bcl9_human(display_long)|uniprotkb:Protein legless homolog(gene name synonym)|uniprotkb:BCL9(gene name)|psi-mi:BCL9(display_short) psi-mi:cdc73_human(display_long)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:C1orf28(gene name synonym)|uniprotkb:HRPT2(gene name synonym)|uniprotkb:Cell division cycle protein 73 homolog(gene name synonym)|uniprotkb:Hyperparathyroidism 2 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Hoffmans et al. (2007) pubmed:17113272|imex:IM-19196 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1385750|imex:IM-19196-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000234739|ensembl:ENSG00000116128(gene)|ensembl:ENST00000234739(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0014908"(myotube differentiation involved in skeletal muscle regeneration)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015668(B Cell Lymphoma 9)|interpro:IPR024670|mint:O00512|rcsb pdb:2GL7|rcsb pdb:2VP7|rcsb pdb:2VPB|rcsb pdb:2VPD|rcsb pdb:2VPE|rcsb pdb:2VPG|rcsb pdb:3SL9|reactome:R-HSA-201722|reactome:R-HSA-3769402|refseq:NP_004317.2|refseq:XP_005273028.1 refseq:NP_078805.3|dip:DIP-37884N|ensembl:ENSG00000134371(gene)|ensembl:ENST00000367435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0031648"(protein destabilization)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR032041|interpro:IPR038103|mint:Q6P1J9|rcsb pdb:5YDE|rcsb pdb:5YDF|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-5632684|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:5 C|comment:"Deletion mutant Bcl9(DeltaPyBD) interacted with parafibromin but to a lesser degree than the wild-type protein."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2007/08/21 2014/10/16 rogid:RCCh4ZkVE2BITRjPSL38IKnaaAk9606 rogid:nuJ2kK0petj8iBr17I2BQzxcVmE9606 intact-crc:A1CB5A786F1C091A|rigid:xydWjSIQ7Mof+DaluliN0d4YcDQ false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)