#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08183	uniprotkb:Q99496	intact:EBI-1057359|uniprotkb:Q12755|uniprotkb:Q14812|uniprotkb:B5AK60|uniprotkb:A8K294|ensembl:ENSP00000265724|ensembl:ENSP00000478255	intact:EBI-722416|uniprotkb:Q5TEN1|uniprotkb:Q5TEN2|uniprotkb:B2RBS7|uniprotkb:B3KRH1|ensembl:ENSP00000356480	psi-mi:mdr1_human(display_long)|uniprotkb:ABCB1(gene name)|psi-mi:ABCB1(display_short)|uniprotkb:MDR1(gene name synonym)|uniprotkb:PGY1(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 1(gene name synonym)|uniprotkb:P-glycoprotein 1(gene name synonym)|uniprotkb:Multidrug resistance protein 1(gene name synonym)|uniprotkb:Phospholipid transporter ABCB1(gene name synonym)	psi-mi:ring2_human(display_long)|uniprotkb:RING finger protein 2(gene name synonym)|uniprotkb:RING finger protein 1B(gene name synonym)|uniprotkb:RING finger protein BAP-1(gene name synonym)|uniprotkb:Protein DinG(gene name synonym)|uniprotkb:Huntingtin-interacting protein 2-interacting protein 3(gene name synonym)|uniprotkb:RNF2(gene name)|psi-mi:RNF2(display_short)|uniprotkb:BAP1(gene name synonym)|uniprotkb:DING(gene name synonym)|uniprotkb:HIPI3(gene name synonym)|uniprotkb:RING1B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RING2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Rao et al. (2006)	pubmed:17088979|imex:IM-19338	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1198183|imex:IM-19338-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000918.2|ensembl:ENST00000622132(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008559"(ABC-type xenobiotic transporter activity)|go:"GO:0009986"(cell surface)|go:"GO:0015562"(efflux transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0046865"(terpenoid transport)|go:"GO:0046943"(carboxylic acid transmembrane transporter activity)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070633"(transepithelial transport)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090555"(phosphatidylethanolamine flippase activity)|go:"GO:0098591"(external side of apical plasma membrane)|go:"GO:0099038"(ceramide floppase activity)|go:"GO:0099040"(ceramide translocation)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1901529"(positive regulation of anion channel activity)|go:"GO:1905039"(carboxylic acid transmembrane transport)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|go:"GO:1990962"(xenobiotic transport across blood-brain barrier)|go:"GO:2001225"(regulation of chloride transport)|interpro:IPR003439(ABC transporter-like)|ensembl:ENSG00000085563(gene)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030258|interpro:IPR036640|interpro:IPR039421|rcsb pdb:6C0V|rcsb pdb:6FN1|rcsb pdb:6FN4|rcsb pdb:6QEX|rcsb pdb:7A65|rcsb pdb:7A69|rcsb pdb:7A6C|rcsb pdb:7A6E|rcsb pdb:7A6F|reactome:R-HSA-2161517|reactome:R-HSA-382556|ensembl:ENST00000265724(transcript)	refseq:NP_009143.1|refseq:XP_011508153.1|refseq:XP_011508154.1|dip:DIP-40034N|ensembl:ENSG00000121481(gene)|ensembl:ENST00000367510(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000791"(euchromatin)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007281"(germ cell development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071535"(RING-like zinc finger domain binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|interpro:IPR037937|interpro:IPR043540|mint:Q99496|rcsb pdb:2H0D|rcsb pdb:3GS2|rcsb pdb:3H8H|rcsb pdb:3IXS|rcsb pdb:3RPG|rcsb pdb:4R8P|rcsb pdb:4S3O|rcsb pdb:7ND1|reactome:R-HSA-2559580|reactome:R-HSA-3108214|reactome:R-HSA-3899300|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4655427|reactome:R-HSA-8939243|reactome:R-HSA-8943724|reactome:R-HSA-8953750	-	-	-	dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/02/06	2014/10/16	rogid:KsfP1PTlAEFXubXg5MahD0rzsSs9606	rogid:pqAjSEwOUdfuogKW6fodqsUSHIk9606	intact-crc:88EEE3FBBBE4E319|rigid:WcAYh6wgKlGRrhkmaS20KS7yLsg	false	sufficient binding region:633-707	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99496	uniprotkb:P08183	intact:EBI-722416|uniprotkb:Q5TEN1|uniprotkb:Q5TEN2|uniprotkb:B2RBS7|uniprotkb:B3KRH1|ensembl:ENSP00000356480	intact:EBI-1057359|uniprotkb:Q12755|uniprotkb:Q14812|uniprotkb:B5AK60|uniprotkb:A8K294|ensembl:ENSP00000265724|ensembl:ENSP00000478255	psi-mi:ring2_human(display_long)|uniprotkb:RING finger protein 2(gene name synonym)|uniprotkb:RING finger protein 1B(gene name synonym)|uniprotkb:RING finger protein BAP-1(gene name synonym)|uniprotkb:Protein DinG(gene name synonym)|uniprotkb:Huntingtin-interacting protein 2-interacting protein 3(gene name synonym)|uniprotkb:RNF2(gene name)|psi-mi:RNF2(display_short)|uniprotkb:BAP1(gene name synonym)|uniprotkb:DING(gene name synonym)|uniprotkb:HIPI3(gene name synonym)|uniprotkb:RING1B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RING2(gene name synonym)	psi-mi:mdr1_human(display_long)|uniprotkb:ABCB1(gene name)|psi-mi:ABCB1(display_short)|uniprotkb:MDR1(gene name synonym)|uniprotkb:PGY1(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 1(gene name synonym)|uniprotkb:P-glycoprotein 1(gene name synonym)|uniprotkb:Multidrug resistance protein 1(gene name synonym)|uniprotkb:Phospholipid transporter ABCB1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rao et al. (2006)	pubmed:17088979|imex:IM-19338	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1199741|imex:IM-19338-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009143.1|refseq:XP_011508153.1|refseq:XP_011508154.1|dip:DIP-40034N|ensembl:ENSG00000121481(gene)|ensembl:ENST00000367510(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000791"(euchromatin)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007281"(germ cell development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071535"(RING-like zinc finger domain binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|interpro:IPR037937|interpro:IPR043540|mint:Q99496|rcsb pdb:2H0D|rcsb pdb:3GS2|rcsb pdb:3H8H|rcsb pdb:3IXS|rcsb pdb:3RPG|rcsb pdb:4R8P|rcsb pdb:4S3O|rcsb pdb:7ND1|reactome:R-HSA-2559580|reactome:R-HSA-3108214|reactome:R-HSA-3899300|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4655427|reactome:R-HSA-8939243|reactome:R-HSA-8943724|reactome:R-HSA-8953750	refseq:NP_000918.2|ensembl:ENST00000622132(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008559"(ABC-type xenobiotic transporter activity)|go:"GO:0009986"(cell surface)|go:"GO:0015562"(efflux transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0046865"(terpenoid transport)|go:"GO:0046943"(carboxylic acid transmembrane transporter activity)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070633"(transepithelial transport)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090555"(phosphatidylethanolamine flippase activity)|go:"GO:0098591"(external side of apical plasma membrane)|go:"GO:0099038"(ceramide floppase activity)|go:"GO:0099040"(ceramide translocation)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1901529"(positive regulation of anion channel activity)|go:"GO:1905039"(carboxylic acid transmembrane transport)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|go:"GO:1990962"(xenobiotic transport across blood-brain barrier)|go:"GO:2001225"(regulation of chloride transport)|interpro:IPR003439(ABC transporter-like)|ensembl:ENSG00000085563(gene)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030258|interpro:IPR036640|interpro:IPR039421|rcsb pdb:6C0V|rcsb pdb:6FN1|rcsb pdb:6FN4|rcsb pdb:6QEX|rcsb pdb:7A65|rcsb pdb:7A69|rcsb pdb:7A6C|rcsb pdb:7A6E|rcsb pdb:7A6F|reactome:R-HSA-2161517|reactome:R-HSA-382556|ensembl:ENST00000265724(transcript)	-	-	-	figure legend:2 B|comment:The detergents NP-40 and Triton X-100 did not disrupt this interaction.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2007/02/06	2014/10/16	rogid:pqAjSEwOUdfuogKW6fodqsUSHIk9606	rogid:KsfP1PTlAEFXubXg5MahD0rzsSs9606	intact-crc:782B04C4E4E17B24|rigid:WcAYh6wgKlGRrhkmaS20KS7yLsg	false	his tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)