#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q86Y07	uniprotkb:P03182	intact:EBI-1207615|uniprotkb:Q49AK9|uniprotkb:Q53EU9|uniprotkb:Q86Y08|uniprotkb:Q86Y09|uniprotkb:Q86Y10|uniprotkb:Q86Y11|uniprotkb:Q86Y12|uniprotkb:Q8IXI5|uniprotkb:Q99987|uniprotkb:Q53S39|uniprotkb:Q53S77|uniprotkb:Q53TU1|uniprotkb:B4DKL0|uniprotkb:D6W5D4|uniprotkb:D6W5D6|ensembl:ENSP00000342381|ensembl:ENSP00000408002	intact:EBI-1207659|uniprotkb:Q777H0	psi-mi:vrk2_human(display_long)|uniprotkb:VRK2(gene name)|psi-mi:VRK2(display_short)|uniprotkb:Vaccinia-related kinase 2(gene name synonym)	psi-mi:ear_ebvb9(display_long)|uniprotkb:BHRF1(orf name)|uniprotkb:Nuclear antigen(gene name synonym)|uniprotkb:Early antigen protein R(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Li et al. (2006)	pubmed:16963744|imex:IM-19932|mint:MINT-6594491	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10377(ebvb9)|taxid:10377("Epstein-Barr virus (strain B95-8) (HHV-4)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1207667|imex:IM-19932-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011531394.1|refseq:XP_006712153.1|refseq:XP_006712154.1|refseq:XP_006712155.1|refseq:XP_006712156.1|refseq:NP_001123952.1|refseq:NP_001123953.1|refseq:NP_001123954.1|refseq:NP_001123955.1|refseq:NP_006287.2|refseq:NP_001275765.1|refseq:NP_001275766.1|refseq:NP_001275767.1|refseq:NP_001275768.1|refseq:XP_005264597.1|refseq:XP_016860347.1|refseq:XP_016860348.1|refseq:XP_016860349.1|refseq:XP_016860350.1|refseq:XP_016860351.1|refseq:XP_016860352.1|ensembl:ENSG00000028116(gene)|ensembl:ENST00000340157(transcript)|ensembl:ENST00000435505(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000659"(regulation of interleukin-1-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:Q86Y07|rcsb pdb:2V62|rcsb pdb:5UU1|rcsb pdb:6NCG|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	refseq:YP_401646.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0033668"(negative regulation by symbiont of host apoptotic process)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1Q59|rcsb pdb:2XPX|dip:DIP-39168N	-	-	-	caution:The protein P03182 relates to BHRF1 from EBV strain B95-8, but the authors in the paper Li et al., 2001 referred to do not specify the strain of EBV. This is the only UniProtKb entry corresponding to BHFR1. The length of the protein used and P03182 are the same.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/02/26	2014/10/16	rogid:sDftNP5rKcTUJgpJAcbJsNzag0I9606	rogid:DBNbYBi528vqDWFgnlSOYFnQsm410377	intact-crc:3F08C4B83B2314FA|rigid:2dZZUzLDFVnze9LLaFW0RSvitkU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q86Y07	uniprotkb:P03182	intact:EBI-1207615|uniprotkb:Q49AK9|uniprotkb:Q53EU9|uniprotkb:Q86Y08|uniprotkb:Q86Y09|uniprotkb:Q86Y10|uniprotkb:Q86Y11|uniprotkb:Q86Y12|uniprotkb:Q8IXI5|uniprotkb:Q99987|uniprotkb:Q53S39|uniprotkb:Q53S77|uniprotkb:Q53TU1|uniprotkb:B4DKL0|uniprotkb:D6W5D4|uniprotkb:D6W5D6|ensembl:ENSP00000342381|ensembl:ENSP00000408002	intact:EBI-1207659|uniprotkb:Q777H0	psi-mi:vrk2_human(display_long)|uniprotkb:VRK2(gene name)|psi-mi:VRK2(display_short)|uniprotkb:Vaccinia-related kinase 2(gene name synonym)	psi-mi:ear_ebvb9(display_long)|uniprotkb:BHRF1(orf name)|uniprotkb:Nuclear antigen(gene name synonym)|uniprotkb:Early antigen protein R(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Li et al. (2006)	pubmed:16963744|imex:IM-19932|mint:MINT-6594491	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10377(ebvb9)|taxid:10377("Epstein-Barr virus (strain B95-8) (HHV-4)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1207680|imex:IM-19932-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011531394.1|refseq:XP_006712153.1|refseq:XP_006712154.1|refseq:XP_006712155.1|refseq:XP_006712156.1|refseq:NP_001123952.1|refseq:NP_001123953.1|refseq:NP_001123954.1|refseq:NP_001123955.1|refseq:NP_006287.2|refseq:NP_001275765.1|refseq:NP_001275766.1|refseq:NP_001275767.1|refseq:NP_001275768.1|refseq:XP_005264597.1|refseq:XP_016860347.1|refseq:XP_016860348.1|refseq:XP_016860349.1|refseq:XP_016860350.1|refseq:XP_016860351.1|refseq:XP_016860352.1|ensembl:ENSG00000028116(gene)|ensembl:ENST00000340157(transcript)|ensembl:ENST00000435505(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000659"(regulation of interleukin-1-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:Q86Y07|rcsb pdb:2V62|rcsb pdb:5UU1|rcsb pdb:6NCG|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	refseq:YP_401646.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0033668"(negative regulation by symbiont of host apoptotic process)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1Q59|rcsb pdb:2XPX|dip:DIP-39168N	-	-	-	figure legend:1 C, 5 B, C, D|caution:The protein P03182 relates to BHRF1 from EBV strain B95-8, but the authors in the paper Li et al., 2001 referred to do not specify the strain of EBV. This is the only UniProtKb entry corresponding to BHFR1. The length of the protein used and P03182 are the same.|comment:"The deletion analysis suggested the last 108 C-terminal residues of VRK2 are important for the interaction. However, as VRK2-(94-508) did not interact with BHRF1, it may be that the first 93 aa contribute to a conformation required for interaction, or there may be an inhibitory domain in aa 94-174."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/02/26	2014/10/16	rogid:sDftNP5rKcTUJgpJAcbJsNzag0I9606	rogid:DBNbYBi528vqDWFgnlSOYFnQsm410377	intact-crc:CE03E9DC7ADB7EF6|rigid:2dZZUzLDFVnze9LLaFW0RSvitkU	false	sufficient binding region:401-508	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q86Y07	uniprotkb:P03182	intact:EBI-1207615|uniprotkb:Q49AK9|uniprotkb:Q53EU9|uniprotkb:Q86Y08|uniprotkb:Q86Y09|uniprotkb:Q86Y10|uniprotkb:Q86Y11|uniprotkb:Q86Y12|uniprotkb:Q8IXI5|uniprotkb:Q99987|uniprotkb:Q53S39|uniprotkb:Q53S77|uniprotkb:Q53TU1|uniprotkb:B4DKL0|uniprotkb:D6W5D4|uniprotkb:D6W5D6|ensembl:ENSP00000342381|ensembl:ENSP00000408002	intact:EBI-1207659|uniprotkb:Q777H0	psi-mi:vrk2_human(display_long)|uniprotkb:VRK2(gene name)|psi-mi:VRK2(display_short)|uniprotkb:Vaccinia-related kinase 2(gene name synonym)	psi-mi:ear_ebvb9(display_long)|uniprotkb:BHRF1(orf name)|uniprotkb:Nuclear antigen(gene name synonym)|uniprotkb:Early antigen protein R(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Li et al. (2006)	pubmed:16963744|imex:IM-19932|mint:MINT-6594491	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10377(ebvb9)|taxid:10377("Epstein-Barr virus (strain B95-8) (HHV-4)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1207837|imex:IM-19932-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011531394.1|refseq:XP_006712153.1|refseq:XP_006712154.1|refseq:XP_006712155.1|refseq:XP_006712156.1|refseq:NP_001123952.1|refseq:NP_001123953.1|refseq:NP_001123954.1|refseq:NP_001123955.1|refseq:NP_006287.2|refseq:NP_001275765.1|refseq:NP_001275766.1|refseq:NP_001275767.1|refseq:NP_001275768.1|refseq:XP_005264597.1|refseq:XP_016860347.1|refseq:XP_016860348.1|refseq:XP_016860349.1|refseq:XP_016860350.1|refseq:XP_016860351.1|refseq:XP_016860352.1|ensembl:ENSG00000028116(gene)|ensembl:ENST00000340157(transcript)|ensembl:ENST00000435505(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000659"(regulation of interleukin-1-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:Q86Y07|rcsb pdb:2V62|rcsb pdb:5UU1|rcsb pdb:6NCG|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	refseq:YP_401646.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0033668"(negative regulation by symbiont of host apoptotic process)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1Q59|rcsb pdb:2XPX|dip:DIP-39168N	-	-	-	figure legend:1 C, 5 F, G, H|caution:The protein P03182 relates to BHRF1 from EBV strain B95-8, but the authors in the paper Li et al., 2001 referred to do not specify the strain of EBV. This is the only UniProtKb entry corresponding to BHFR1. The length of the protein used and P03182 are the same.|comment:"Deletion analysis suggests the first 18 aa (including BH4 domain) and aa 89-142 (including BH1 domain) of BHRF1 are important for binding VRK2."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/02/26	2014/10/16	rogid:sDftNP5rKcTUJgpJAcbJsNzag0I9606	rogid:DBNbYBi528vqDWFgnlSOYFnQsm410377	intact-crc:1F523CD1AC425E93|rigid:2dZZUzLDFVnze9LLaFW0RSvitkU	false	-	sufficient binding region:1-142	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10415	uniprotkb:Q86Y07	intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5	intact:EBI-1207615|uniprotkb:Q49AK9|uniprotkb:Q53EU9|uniprotkb:Q86Y08|uniprotkb:Q86Y09|uniprotkb:Q86Y10|uniprotkb:Q86Y11|uniprotkb:Q86Y12|uniprotkb:Q8IXI5|uniprotkb:Q99987|uniprotkb:Q53S39|uniprotkb:Q53S77|uniprotkb:Q53TU1|uniprotkb:B4DKL0|uniprotkb:D6W5D4|uniprotkb:D6W5D6|ensembl:ENSP00000342381|ensembl:ENSP00000408002	psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)	psi-mi:vrk2_human(display_long)|uniprotkb:VRK2(gene name)|psi-mi:VRK2(display_short)|uniprotkb:Vaccinia-related kinase 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Li et al. (2006)	pubmed:16963744|imex:IM-19932|mint:MINT-6594491	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1207847|imex:IM-19932-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2	refseq:XP_011531394.1|refseq:XP_006712153.1|refseq:XP_006712154.1|refseq:XP_006712155.1|refseq:XP_006712156.1|refseq:NP_001123952.1|refseq:NP_001123953.1|refseq:NP_001123954.1|refseq:NP_001123955.1|refseq:NP_006287.2|refseq:NP_001275765.1|refseq:NP_001275766.1|refseq:NP_001275767.1|refseq:NP_001275768.1|refseq:XP_005264597.1|refseq:XP_016860347.1|refseq:XP_016860348.1|refseq:XP_016860349.1|refseq:XP_016860350.1|refseq:XP_016860351.1|refseq:XP_016860352.1|ensembl:ENSG00000028116(gene)|ensembl:ENST00000340157(transcript)|ensembl:ENST00000435505(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000659"(regulation of interleukin-1-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:Q86Y07|rcsb pdb:2V62|rcsb pdb:5UU1|rcsb pdb:6NCG|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	-	-	-	figure legend:1 C, 5 F, G, H|comment:There was a positive reaction after 8 h. Thus the authors term this weaker than the interaction with BHFR1 which occurs within 30 min.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/02/26	2014/10/16	rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606	rogid:sDftNP5rKcTUJgpJAcbJsNzag0I9606	intact-crc:E846C2F46C250D9D|rigid:VpNdGIecsJpwQBCM7Vw2doauh+E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03182	uniprotkb:Q86Y07	intact:EBI-1207659|uniprotkb:Q777H0	intact:EBI-1207615|uniprotkb:Q49AK9|uniprotkb:Q53EU9|uniprotkb:Q86Y08|uniprotkb:Q86Y09|uniprotkb:Q86Y10|uniprotkb:Q86Y11|uniprotkb:Q86Y12|uniprotkb:Q8IXI5|uniprotkb:Q99987|uniprotkb:Q53S39|uniprotkb:Q53S77|uniprotkb:Q53TU1|uniprotkb:B4DKL0|uniprotkb:D6W5D4|uniprotkb:D6W5D6|ensembl:ENSP00000342381|ensembl:ENSP00000408002	psi-mi:ear_ebvb9(display_long)|uniprotkb:BHRF1(orf name)|uniprotkb:Nuclear antigen(gene name synonym)|uniprotkb:Early antigen protein R(gene name synonym)	psi-mi:vrk2_human(display_long)|uniprotkb:VRK2(gene name)|psi-mi:VRK2(display_short)|uniprotkb:Vaccinia-related kinase 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2006)	pubmed:16963744|imex:IM-19932|mint:MINT-6594491	taxid:10377(ebvb9)|taxid:10377("Epstein-Barr virus (strain B95-8) (HHV-4)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1207694|imex:IM-19932-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_401646.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0033668"(negative regulation by symbiont of host apoptotic process)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1Q59|rcsb pdb:2XPX|dip:DIP-39168N	refseq:XP_011531394.1|refseq:XP_006712153.1|refseq:XP_006712154.1|refseq:XP_006712155.1|refseq:XP_006712156.1|refseq:NP_001123952.1|refseq:NP_001123953.1|refseq:NP_001123954.1|refseq:NP_001123955.1|refseq:NP_006287.2|refseq:NP_001275765.1|refseq:NP_001275766.1|refseq:NP_001275767.1|refseq:NP_001275768.1|refseq:XP_005264597.1|refseq:XP_016860347.1|refseq:XP_016860348.1|refseq:XP_016860349.1|refseq:XP_016860350.1|refseq:XP_016860351.1|refseq:XP_016860352.1|ensembl:ENSG00000028116(gene)|ensembl:ENST00000340157(transcript)|ensembl:ENST00000435505(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000659"(regulation of interleukin-1-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:Q86Y07|rcsb pdb:2V62|rcsb pdb:5UU1|rcsb pdb:6NCG|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	-	-	-	figure legend:2 C|caution:The protein P03182 relates to BHRF1 from EBV strain B95-8, but the authors in the paper Li et al., 2001 referred to do not specify the strain of EBV. This is the only UniProtKb entry corresponding to BHFR1. The length of the protein used and P03182 are the same.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/02/26	2014/10/16	rogid:DBNbYBi528vqDWFgnlSOYFnQsm410377	rogid:sDftNP5rKcTUJgpJAcbJsNzag0I9606	intact-crc:BCCA4B814253E74A|rigid:2dZZUzLDFVnze9LLaFW0RSvitkU	false	glutathione s tranferase tag:?-?	ha tag:?-?|35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03182	uniprotkb:Q86Y07	intact:EBI-1207659|uniprotkb:Q777H0	intact:EBI-1207615|uniprotkb:Q49AK9|uniprotkb:Q53EU9|uniprotkb:Q86Y08|uniprotkb:Q86Y09|uniprotkb:Q86Y10|uniprotkb:Q86Y11|uniprotkb:Q86Y12|uniprotkb:Q8IXI5|uniprotkb:Q99987|uniprotkb:Q53S39|uniprotkb:Q53S77|uniprotkb:Q53TU1|uniprotkb:B4DKL0|uniprotkb:D6W5D4|uniprotkb:D6W5D6|ensembl:ENSP00000342381|ensembl:ENSP00000408002	psi-mi:ear_ebvb9(display_long)|uniprotkb:BHRF1(orf name)|uniprotkb:Nuclear antigen(gene name synonym)|uniprotkb:Early antigen protein R(gene name synonym)	psi-mi:vrk2_human(display_long)|uniprotkb:VRK2(gene name)|psi-mi:VRK2(display_short)|uniprotkb:Vaccinia-related kinase 2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Li et al. (2006)	pubmed:16963744|imex:IM-19932|mint:MINT-6594491	taxid:10377(ebvb9)|taxid:10377("Epstein-Barr virus (strain B95-8) (HHV-4)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1207754|imex:IM-19932-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_401646.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0033668"(negative regulation by symbiont of host apoptotic process)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1Q59|rcsb pdb:2XPX|dip:DIP-39168N	refseq:XP_011531394.1|refseq:XP_006712153.1|refseq:XP_006712154.1|refseq:XP_006712155.1|refseq:XP_006712156.1|refseq:NP_001123952.1|refseq:NP_001123953.1|refseq:NP_001123954.1|refseq:NP_001123955.1|refseq:NP_006287.2|refseq:NP_001275765.1|refseq:NP_001275766.1|refseq:NP_001275767.1|refseq:NP_001275768.1|refseq:XP_005264597.1|refseq:XP_016860347.1|refseq:XP_016860348.1|refseq:XP_016860349.1|refseq:XP_016860350.1|refseq:XP_016860351.1|refseq:XP_016860352.1|ensembl:ENSG00000028116(gene)|ensembl:ENST00000340157(transcript)|ensembl:ENST00000435505(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000659"(regulation of interleukin-1-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:Q86Y07|rcsb pdb:2V62|rcsb pdb:5UU1|rcsb pdb:6NCG|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	-	-	-	figure legend:3|caution:The protein P03182 relates to BHRF1 from EBV strain B95-8, but the authors in the paper Li et al., 2001 referred to do not specify the strain of EBV. This is the only UniProtKb entry corresponding to BHFR1. The length of the protein used and P03182 are the same.|delivery method:Q86Y07; P03182 transfection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rhek_1)|taxid:9606(Homo sapiens keratinocyte cell line RHEK-1)	-	2007/02/26	2014/10/16	rogid:DBNbYBi528vqDWFgnlSOYFnQsm410377	rogid:sDftNP5rKcTUJgpJAcbJsNzag0I9606	intact-crc:FC19644000963467|rigid:2dZZUzLDFVnze9LLaFW0RSvitkU	false	-	ha tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q86Y07	uniprotkb:P03182	intact:EBI-1207615|uniprotkb:Q49AK9|uniprotkb:Q53EU9|uniprotkb:Q86Y08|uniprotkb:Q86Y09|uniprotkb:Q86Y10|uniprotkb:Q86Y11|uniprotkb:Q86Y12|uniprotkb:Q8IXI5|uniprotkb:Q99987|uniprotkb:Q53S39|uniprotkb:Q53S77|uniprotkb:Q53TU1|uniprotkb:B4DKL0|uniprotkb:D6W5D4|uniprotkb:D6W5D6|ensembl:ENSP00000342381|ensembl:ENSP00000408002	intact:EBI-1207659|uniprotkb:Q777H0	psi-mi:vrk2_human(display_long)|uniprotkb:VRK2(gene name)|psi-mi:VRK2(display_short)|uniprotkb:Vaccinia-related kinase 2(gene name synonym)	psi-mi:ear_ebvb9(display_long)|uniprotkb:BHRF1(orf name)|uniprotkb:Nuclear antigen(gene name synonym)|uniprotkb:Early antigen protein R(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2006)	pubmed:16963744|imex:IM-19932|mint:MINT-6594491	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10377(ebvb9)|taxid:10377("Epstein-Barr virus (strain B95-8) (HHV-4)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1207794|imex:IM-19932-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011531394.1|refseq:XP_006712153.1|refseq:XP_006712154.1|refseq:XP_006712155.1|refseq:XP_006712156.1|refseq:NP_001123952.1|refseq:NP_001123953.1|refseq:NP_001123954.1|refseq:NP_001123955.1|refseq:NP_006287.2|refseq:NP_001275765.1|refseq:NP_001275766.1|refseq:NP_001275767.1|refseq:NP_001275768.1|refseq:XP_005264597.1|refseq:XP_016860347.1|refseq:XP_016860348.1|refseq:XP_016860349.1|refseq:XP_016860350.1|refseq:XP_016860351.1|refseq:XP_016860352.1|ensembl:ENSG00000028116(gene)|ensembl:ENST00000340157(transcript)|ensembl:ENST00000435505(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000659"(regulation of interleukin-1-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:Q86Y07|rcsb pdb:2V62|rcsb pdb:5UU1|rcsb pdb:6NCG|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	refseq:YP_401646.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0033668"(negative regulation by symbiont of host apoptotic process)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1Q59|rcsb pdb:2XPX|dip:DIP-39168N	-	-	-	figure legend:4 B|caution:The protein P03182 relates to BHRF1 from EBV strain B95-8, but the authors in the paper Li et al., 2001 referred to do not specify the strain of EBV. This is the only UniProtKb entry corresponding to BHFR1. The length of the protein used and P03182 are the same.|delivery method:Q86Y07; P03182 transfection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rhek_1)|taxid:9606(Homo sapiens keratinocyte cell line RHEK-1)	-	2007/02/26	2014/10/16	rogid:sDftNP5rKcTUJgpJAcbJsNzag0I9606	rogid:DBNbYBi528vqDWFgnlSOYFnQsm410377	intact-crc:853754552170E80C|rigid:2dZZUzLDFVnze9LLaFW0RSvitkU	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q86Y07	uniprotkb:P03182	intact:EBI-1207615|uniprotkb:Q49AK9|uniprotkb:Q53EU9|uniprotkb:Q86Y08|uniprotkb:Q86Y09|uniprotkb:Q86Y10|uniprotkb:Q86Y11|uniprotkb:Q86Y12|uniprotkb:Q8IXI5|uniprotkb:Q99987|uniprotkb:Q53S39|uniprotkb:Q53S77|uniprotkb:Q53TU1|uniprotkb:B4DKL0|uniprotkb:D6W5D4|uniprotkb:D6W5D6|ensembl:ENSP00000342381|ensembl:ENSP00000408002	intact:EBI-1207659|uniprotkb:Q777H0	psi-mi:vrk2_human(display_long)|uniprotkb:VRK2(gene name)|psi-mi:VRK2(display_short)|uniprotkb:Vaccinia-related kinase 2(gene name synonym)	psi-mi:ear_ebvb9(display_long)|uniprotkb:BHRF1(orf name)|uniprotkb:Nuclear antigen(gene name synonym)|uniprotkb:Early antigen protein R(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2006)	pubmed:16963744|imex:IM-19932|mint:MINT-6594491	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10377(ebvb9)|taxid:10377("Epstein-Barr virus (strain B95-8) (HHV-4)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1207814|imex:IM-19932-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011531394.1|refseq:XP_006712153.1|refseq:XP_006712154.1|refseq:XP_006712155.1|refseq:XP_006712156.1|refseq:NP_001123952.1|refseq:NP_001123953.1|refseq:NP_001123954.1|refseq:NP_001123955.1|refseq:NP_006287.2|refseq:NP_001275765.1|refseq:NP_001275766.1|refseq:NP_001275767.1|refseq:NP_001275768.1|refseq:XP_005264597.1|refseq:XP_016860347.1|refseq:XP_016860348.1|refseq:XP_016860349.1|refseq:XP_016860350.1|refseq:XP_016860351.1|refseq:XP_016860352.1|ensembl:ENSG00000028116(gene)|ensembl:ENST00000340157(transcript)|ensembl:ENST00000435505(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000659"(regulation of interleukin-1-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:Q86Y07|rcsb pdb:2V62|rcsb pdb:5UU1|rcsb pdb:6NCG|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	refseq:YP_401646.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0033668"(negative regulation by symbiont of host apoptotic process)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1Q59|rcsb pdb:2XPX|dip:DIP-39168N	-	-	-	figure legend:4 B|caution:The protein P03182 relates to BHRF1 from EBV strain B95-8, but the authors in the paper Li et al., 2001 referred to do not specify the strain of EBV. This is the only UniProtKb entry corresponding to BHFR1. The length of the protein used and P03182 are the same.|delivery method:Q86Y07; P03182 transfection|caution:This interaction is shown in 4 B, although in the text there is a note that data is not shown.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rhek_1)|taxid:9606(Homo sapiens keratinocyte cell line RHEK-1)	-	2007/02/26	2014/10/16	rogid:sDftNP5rKcTUJgpJAcbJsNzag0I9606	rogid:DBNbYBi528vqDWFgnlSOYFnQsm410377	intact-crc:0D2B9C759E8BF6CD|rigid:2dZZUzLDFVnze9LLaFW0RSvitkU	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)