#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P06700	uniprotkb:P32354	intact:EBI-17219|uniprotkb:D6VRV4|ensemblfungi:YDL042C	intact:EBI-5965|uniprotkb:D6VVD7|ensemblfungi:YIL150C	psi-mi:sir2_yeast(display_long)|uniprotkb:SIR2(gene name)|psi-mi:SIR2(display_short)|uniprotkb:MAR1(gene name synonym)|uniprotkb:YDL042C(locus name)|uniprotkb:D2714(orf name)|uniprotkb:Silent information regulator 2(gene name synonym)|uniprotkb:Regulatory protein SIR2(gene name synonym)	psi-mi:mcm10_yeast(display_long)|uniprotkb:YIL150C(locus name)|uniprotkb:MCM10(gene name)|psi-mi:MCM10(display_short)|uniprotkb:DNA43(gene name synonym)|uniprotkb:Protein DNA43(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Douglas et al. (2005)	pubmed:16328881|imex:IM-24992	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1565438|imex:IM-24992-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010242.1|sgd:S000002200|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0046970"("NAD-dependent histone deacetylase activity (H4-K16 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0097752"(regulation of DNA stability)|go:"GO:1904524"(negative regulation of DNA amplification)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR007654(Protein of unknown function DUF592)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:2HJH|rcsb pdb:4IAO|go:"GO:0034398"(telomere tethering at nuclear periphery)|ensemblfungi:YDL042C_mRNA(transcript)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006325"(chromatin organization)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006348"|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0016740"(transferase activity)|ensemblfungi:YDL042C(gene)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030869"(RENT complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|dip:DIP-596N|mint:P06700	refseq:NP_012116.1|sgd:S000001412|dip:DIP-1293N|mint:P32354|ensemblfungi:YIL150C(gene)|ensemblfungi:YIL150C_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006348"|go:"GO:0007049"(cell cycle)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015408(Zinc finger, Mcm10/DnaG-type)|interpro:IPR040184|reactome:R-SCE-68962	-	crc64:52E6937533654586	-	figure legend:"Fig: 4"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/12/06	2016/01/29	rogid:HSrFe/tNeIjMNN3xB+3h7rocgkU559292	rogid:D2K/tLON/CnIcTTqkAQOdTZrRlg559292	intact-crc:360A022319EBF848|rigid:fqWNbWW6dBMWfzzwfXjuqYjcM6c	false	necessary binding region:?-?	necessary binding region:464-571|mutation disrupting interaction strength:269-269|mutation decreasing interaction strength:320-320	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06701	uniprotkb:P32354	intact:EBI-17230|uniprotkb:D6VZ77|uniprotkb:E9P924|ensemblfungi:YLR442C	intact:EBI-5965|uniprotkb:D6VVD7|ensemblfungi:YIL150C	psi-mi:sir3_yeast(display_long)|uniprotkb:SIR3(gene name)|psi-mi:SIR3(display_short)|uniprotkb:CMT1(gene name synonym)|uniprotkb:MAR2(gene name synonym)|uniprotkb:STE8(gene name synonym)|uniprotkb:L9753.10(orf name)|uniprotkb:YLR442C(locus name)|uniprotkb:Silent information regulator 3(gene name synonym)	psi-mi:mcm10_yeast(display_long)|uniprotkb:YIL150C(locus name)|uniprotkb:MCM10(gene name)|psi-mi:MCM10(display_short)|uniprotkb:DNA43(gene name synonym)|uniprotkb:Protein DNA43(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Douglas et al. (2005)	pubmed:16328881|imex:IM-24992	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1565456|imex:IM-24992-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013547.3|sgd:S000004434|ensemblfungi:YLR442C(gene)|ensemblfungi:YLR442C_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0042802"(identical protein binding)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|rcsb pdb:2FL7|rcsb pdb:2FVU|rcsb pdb:3OWT|rcsb pdb:3TE6|rcsb pdb:3TU4|rcsb pdb:3ZCO|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4KUL|rcsb pdb:4LD9|rcsb pdb:4KUI|dip:DIP-595N|mint:P06701	refseq:NP_012116.1|sgd:S000001412|dip:DIP-1293N|mint:P32354|ensemblfungi:YIL150C(gene)|ensemblfungi:YIL150C_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006348"|go:"GO:0007049"(cell cycle)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015408(Zinc finger, Mcm10/DnaG-type)|interpro:IPR040184|reactome:R-SCE-68962	-	crc64:CA2503D7645397AC	-	figure legend:"Fig: 4"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/12/06	2016/01/29	rogid:M+pLXY5ZyBMA0tQaEIwTkK6U2SE559292	rogid:D2K/tLON/CnIcTTqkAQOdTZrRlg559292	intact-crc:B7121AB22E0F0327|rigid:IoxbrZkEEHoUEXNgXnrP9dU0m8A	false	-	mutation disrupting interaction strength:269-269|mutation disrupting interaction strength:320-320	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)