#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P21980	uniprotkb:Q12802	intact:EBI-727668|uniprotkb:Q16436|uniprotkb:Q9BTN7|uniprotkb:Q9UH35|uniprotkb:Q6B838|uniprotkb:E1P5V9|ensembl:ENSP00000355330|uniprotkb:Q9H035	intact:EBI-1373806|uniprotkb:Q14572|uniprotkb:Q59FP6|uniprotkb:Q86W90|uniprotkb:Q8WXQ6|uniprotkb:Q96JP6|uniprotkb:Q96P79|uniprotkb:Q9Y5T0|uniprotkb:Q9Y5T6|intact:EBI-28978093|ensembl:ENSP00000378026	psi-mi:tgm2_human(display_long)|uniprotkb:TGM2(gene name)|psi-mi:TGM2(display_short)|uniprotkb:Tissue transglutaminase(gene name synonym)|uniprotkb:Transglutaminase C(gene name synonym)|uniprotkb:Transglutaminase-2(gene name synonym)|uniprotkb:Transglutaminase H(gene name synonym)|uniprotkb:Erythrocyte transglutaminase(gene name synonym)|uniprotkb:"Heart G alpha(h)"(gene name synonym)|uniprotkb:Isopeptidase TGM2(gene name synonym)|uniprotkb:"Protein G alpha(h)"(gene name synonym)|uniprotkb:Protein-glutamine deamidase TGM2(gene name synonym)|uniprotkb:Protein-glutamine dopaminyltransferase TGM2(gene name synonym)|uniprotkb:Protein-glutamine histaminyltransferase TGM2(gene name synonym)|uniprotkb:Protein-glutamine noradrenalinyltransferase TGM2(gene name synonym)|uniprotkb:Protein-glutamine serotonyltransferase TGM2(gene name synonym)|uniprotkb:Transglutaminase II(gene name synonym)	psi-mi:akp13_human(display_long)|uniprotkb:Protein kinase A-anchoring protein 13(gene name synonym)|uniprotkb:Breast cancer nuclear receptor-binding auxiliary protein(gene name synonym)|uniprotkb:Human thyroid-anchoring protein 31(gene name synonym)|uniprotkb:Guanine nucleotide exchange factor Lbc(gene name synonym)|uniprotkb:AKAP-Lbc(gene name synonym)|uniprotkb:p47(gene name synonym)|uniprotkb:Lymphoid blast crisis oncogene(gene name synonym)|uniprotkb:Non-oncogenic Rho GTPase-specific GTP exchange factor(gene name synonym)|uniprotkb:AKAP13(gene name)|psi-mi:AKAP13(display_short)|uniprotkb:BRX(gene name synonym)|uniprotkb:HT31(gene name synonym)|uniprotkb:LBC(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Lewis et al. (2005)	pubmed:16301118|imex:IM-19946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1373886|imex:IM-19946-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004604.2|refseq:NP_945189.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0018153"("isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine")|go:"GO:0018277"(protein deamination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031226"(intrinsic component of plasma membrane)|ensembl:ENSG00000198959(gene)|ensembl:ENST00000361475(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003810"(protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050568"(protein-glutamine glutaminase activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0060348"(bone development)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0120295"(histone serotonyltransferase activity)|go:"GO:0120297"(histone dopaminyltransferase activity)|go:"GO:0120298"(peptide noradrenalinyltransferase activity)|go:"GO:0120299"(peptide histaminyltransferase activity)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904015"(cellular response to serotonin)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|interpro:IPR001102(Transglutaminase, N-terminal)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR008958(Transglutaminase, C-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013808(Transglutaminase, conserved site)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR023608|interpro:IPR036238|interpro:IPR036985|interpro:IPR038765|mint:P21980|rcsb pdb:1FAU|rcsb pdb:1KV3|rcsb pdb:2Q3Z|rcsb pdb:3LY6|rcsb pdb:3S3J|rcsb pdb:3S3P|rcsb pdb:3S3S|rcsb pdb:4PYG|rcsb pdb:6A8P|rcsb pdb:6KZB|go:"GO:2000425"(regulation of apoptotic cell clearance)|refseq:XP_011527330.1|refseq:NP_001310245.1|dip:DIP-33557N	refseq:NP_006729.4|refseq:NP_009131.2|ensembl:ENST00000361243|ensembl:ENSP00000354718|ensembl:ENSP00000378026|ensembl:ENST00000560302|ensembl:ENSP00000453634|refseq:NP_001257475.1|dip:DIP-180N|ensembl:ENSG00000170776(gene)|ensembl:ENST00000394518(transcript)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051168"(nuclear export)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060348"(bone development)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0086023"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018459|interpro:IPR028852|interpro:IPR035899|interpro:IPR041020|mint:Q12802|rcsb pdb:2DRN|rcsb pdb:2LG1|rcsb pdb:4D0N|rcsb pdb:4D0O|rcsb pdb:6BCA|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106	omim:176807(primary-reference)	-	-	author-identifiers:PREY gene BC050312|comment:3 AKAP13 cDNA clones showed approx. 94% homology with BC050312.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/24	2014/10/16	rogid:S61on+x/CwI9G/k/0UhS6pFO+wE9606	rogid:pHHpKUh10J/O/fp06k4NaNhJF6U9606	intact-crc:1B512D8A8F95BF5F|rigid:pTevzW6x9IrzfuHVsfguuypw7rI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P21980	uniprotkb:Q12802	intact:EBI-727668|uniprotkb:Q16436|uniprotkb:Q9BTN7|uniprotkb:Q9UH35|uniprotkb:Q6B838|uniprotkb:E1P5V9|ensembl:ENSP00000355330|uniprotkb:Q9H035	intact:EBI-1373806|uniprotkb:Q14572|uniprotkb:Q59FP6|uniprotkb:Q86W90|uniprotkb:Q8WXQ6|uniprotkb:Q96JP6|uniprotkb:Q96P79|uniprotkb:Q9Y5T0|uniprotkb:Q9Y5T6|intact:EBI-28978093|ensembl:ENSP00000378026	psi-mi:tgm2_human(display_long)|uniprotkb:TGM2(gene name)|psi-mi:TGM2(display_short)|uniprotkb:Tissue transglutaminase(gene name synonym)|uniprotkb:Transglutaminase C(gene name synonym)|uniprotkb:Transglutaminase-2(gene name synonym)|uniprotkb:Transglutaminase H(gene name synonym)|uniprotkb:Erythrocyte transglutaminase(gene name synonym)|uniprotkb:"Heart G alpha(h)"(gene name synonym)|uniprotkb:Isopeptidase TGM2(gene name synonym)|uniprotkb:"Protein G alpha(h)"(gene name synonym)|uniprotkb:Protein-glutamine deamidase TGM2(gene name synonym)|uniprotkb:Protein-glutamine dopaminyltransferase TGM2(gene name synonym)|uniprotkb:Protein-glutamine histaminyltransferase TGM2(gene name synonym)|uniprotkb:Protein-glutamine noradrenalinyltransferase TGM2(gene name synonym)|uniprotkb:Protein-glutamine serotonyltransferase TGM2(gene name synonym)|uniprotkb:Transglutaminase II(gene name synonym)	psi-mi:akp13_human(display_long)|uniprotkb:Protein kinase A-anchoring protein 13(gene name synonym)|uniprotkb:Breast cancer nuclear receptor-binding auxiliary protein(gene name synonym)|uniprotkb:Human thyroid-anchoring protein 31(gene name synonym)|uniprotkb:Guanine nucleotide exchange factor Lbc(gene name synonym)|uniprotkb:AKAP-Lbc(gene name synonym)|uniprotkb:p47(gene name synonym)|uniprotkb:Lymphoid blast crisis oncogene(gene name synonym)|uniprotkb:Non-oncogenic Rho GTPase-specific GTP exchange factor(gene name synonym)|uniprotkb:AKAP13(gene name)|psi-mi:AKAP13(display_short)|uniprotkb:BRX(gene name synonym)|uniprotkb:HT31(gene name synonym)|uniprotkb:LBC(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lewis et al. (2005)	pubmed:16301118|imex:IM-19946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1373897|imex:IM-19946-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004604.2|refseq:NP_945189.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0018153"("isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine")|go:"GO:0018277"(protein deamination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031226"(intrinsic component of plasma membrane)|ensembl:ENSG00000198959(gene)|ensembl:ENST00000361475(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003810"(protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050568"(protein-glutamine glutaminase activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0060348"(bone development)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0120295"(histone serotonyltransferase activity)|go:"GO:0120297"(histone dopaminyltransferase activity)|go:"GO:0120298"(peptide noradrenalinyltransferase activity)|go:"GO:0120299"(peptide histaminyltransferase activity)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904015"(cellular response to serotonin)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|interpro:IPR001102(Transglutaminase, N-terminal)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR008958(Transglutaminase, C-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013808(Transglutaminase, conserved site)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR023608|interpro:IPR036238|interpro:IPR036985|interpro:IPR038765|mint:P21980|rcsb pdb:1FAU|rcsb pdb:1KV3|rcsb pdb:2Q3Z|rcsb pdb:3LY6|rcsb pdb:3S3J|rcsb pdb:3S3P|rcsb pdb:3S3S|rcsb pdb:4PYG|rcsb pdb:6A8P|rcsb pdb:6KZB|go:"GO:2000425"(regulation of apoptotic cell clearance)|refseq:XP_011527330.1|refseq:NP_001310245.1|dip:DIP-33557N	refseq:NP_006729.4|refseq:NP_009131.2|ensembl:ENST00000361243|ensembl:ENSP00000354718|ensembl:ENSP00000378026|ensembl:ENST00000560302|ensembl:ENSP00000453634|refseq:NP_001257475.1|dip:DIP-180N|ensembl:ENSG00000170776(gene)|ensembl:ENST00000394518(transcript)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051168"(nuclear export)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060348"(bone development)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0086023"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018459|interpro:IPR028852|interpro:IPR035899|interpro:IPR041020|mint:Q12802|rcsb pdb:2DRN|rcsb pdb:2LG1|rcsb pdb:4D0N|rcsb pdb:4D0O|rcsb pdb:6BCA|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106	omim:176807(primary-reference)	-	-	author-identifiers:BAIT gene BC050312|figure legend:1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-pc3)|taxid:9606(Human PC3 Caucasian prostate adenocarcinoma)	-	2007/07/24	2014/10/16	rogid:S61on+x/CwI9G/k/0UhS6pFO+wE9606	rogid:pHHpKUh10J/O/fp06k4NaNhJF6U9606	intact-crc:CDF4929B9F4BD80B|rigid:pTevzW6x9IrzfuHVsfguuypw7rI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12802	uniprotkb:P21980	intact:EBI-1373806|uniprotkb:Q14572|uniprotkb:Q59FP6|uniprotkb:Q86W90|uniprotkb:Q8WXQ6|uniprotkb:Q96JP6|uniprotkb:Q96P79|uniprotkb:Q9Y5T0|uniprotkb:Q9Y5T6|intact:EBI-28978093|ensembl:ENSP00000378026	intact:EBI-727668|uniprotkb:Q16436|uniprotkb:Q9BTN7|uniprotkb:Q9UH35|uniprotkb:Q6B838|uniprotkb:E1P5V9|ensembl:ENSP00000355330|uniprotkb:Q9H035	psi-mi:akp13_human(display_long)|uniprotkb:Protein kinase A-anchoring protein 13(gene name synonym)|uniprotkb:Breast cancer nuclear receptor-binding auxiliary protein(gene name synonym)|uniprotkb:Human thyroid-anchoring protein 31(gene name synonym)|uniprotkb:Guanine nucleotide exchange factor Lbc(gene name synonym)|uniprotkb:AKAP-Lbc(gene name synonym)|uniprotkb:p47(gene name synonym)|uniprotkb:Lymphoid blast crisis oncogene(gene name synonym)|uniprotkb:Non-oncogenic Rho GTPase-specific GTP exchange factor(gene name synonym)|uniprotkb:AKAP13(gene name)|psi-mi:AKAP13(display_short)|uniprotkb:BRX(gene name synonym)|uniprotkb:HT31(gene name synonym)|uniprotkb:LBC(gene name synonym)	psi-mi:tgm2_human(display_long)|uniprotkb:TGM2(gene name)|psi-mi:TGM2(display_short)|uniprotkb:Tissue transglutaminase(gene name synonym)|uniprotkb:Transglutaminase C(gene name synonym)|uniprotkb:Transglutaminase-2(gene name synonym)|uniprotkb:Transglutaminase H(gene name synonym)|uniprotkb:Erythrocyte transglutaminase(gene name synonym)|uniprotkb:"Heart G alpha(h)"(gene name synonym)|uniprotkb:Isopeptidase TGM2(gene name synonym)|uniprotkb:"Protein G alpha(h)"(gene name synonym)|uniprotkb:Protein-glutamine deamidase TGM2(gene name synonym)|uniprotkb:Protein-glutamine dopaminyltransferase TGM2(gene name synonym)|uniprotkb:Protein-glutamine histaminyltransferase TGM2(gene name synonym)|uniprotkb:Protein-glutamine noradrenalinyltransferase TGM2(gene name synonym)|uniprotkb:Protein-glutamine serotonyltransferase TGM2(gene name synonym)|uniprotkb:Transglutaminase II(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Lewis et al. (2005)	pubmed:16301118|imex:IM-19946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1373927|imex:IM-19946-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006729.4|refseq:NP_009131.2|ensembl:ENST00000361243|ensembl:ENSP00000354718|ensembl:ENSP00000378026|ensembl:ENST00000560302|ensembl:ENSP00000453634|refseq:NP_001257475.1|dip:DIP-180N|ensembl:ENSG00000170776(gene)|ensembl:ENST00000394518(transcript)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051168"(nuclear export)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060348"(bone development)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0086023"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018459|interpro:IPR028852|interpro:IPR035899|interpro:IPR041020|mint:Q12802|rcsb pdb:2DRN|rcsb pdb:2LG1|rcsb pdb:4D0N|rcsb pdb:4D0O|rcsb pdb:6BCA|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106	refseq:NP_004604.2|refseq:NP_945189.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0018153"("isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine")|go:"GO:0018277"(protein deamination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031226"(intrinsic component of plasma membrane)|ensembl:ENSG00000198959(gene)|ensembl:ENST00000361475(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003810"(protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050568"(protein-glutamine glutaminase activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0060348"(bone development)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0120295"(histone serotonyltransferase activity)|go:"GO:0120297"(histone dopaminyltransferase activity)|go:"GO:0120298"(peptide noradrenalinyltransferase activity)|go:"GO:0120299"(peptide histaminyltransferase activity)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904015"(cellular response to serotonin)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|interpro:IPR001102(Transglutaminase, N-terminal)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR008958(Transglutaminase, C-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013808(Transglutaminase, conserved site)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR023608|interpro:IPR036238|interpro:IPR036985|interpro:IPR038765|mint:P21980|rcsb pdb:1FAU|rcsb pdb:1KV3|rcsb pdb:2Q3Z|rcsb pdb:3LY6|rcsb pdb:3S3J|rcsb pdb:3S3P|rcsb pdb:3S3S|rcsb pdb:4PYG|rcsb pdb:6A8P|rcsb pdb:6KZB|go:"GO:2000425"(regulation of apoptotic cell clearance)|refseq:XP_011527330.1|refseq:NP_001310245.1|dip:DIP-33557N	omim:176807(primary-reference)|go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	author-identifiers:Q12802 gene BC050312|figure legend:2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-pc3)|taxid:9606(Human PC3 Caucasian prostate adenocarcinoma)	-	2007/07/24	2014/10/16	rogid:pHHpKUh10J/O/fp06k4NaNhJF6U9606	rogid:S61on+x/CwI9G/k/0UhS6pFO+wE9606	intact-crc:7F1A3A36657CAE38|rigid:pTevzW6x9IrzfuHVsfguuypw7rI	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P21980	uniprotkb:Q12802	intact:EBI-727668|uniprotkb:Q16436|uniprotkb:Q9BTN7|uniprotkb:Q9UH35|uniprotkb:Q6B838|uniprotkb:E1P5V9|ensembl:ENSP00000355330|uniprotkb:Q9H035	intact:EBI-1373806|uniprotkb:Q14572|uniprotkb:Q59FP6|uniprotkb:Q86W90|uniprotkb:Q8WXQ6|uniprotkb:Q96JP6|uniprotkb:Q96P79|uniprotkb:Q9Y5T0|uniprotkb:Q9Y5T6|intact:EBI-28978093|ensembl:ENSP00000378026	psi-mi:tgm2_human(display_long)|uniprotkb:TGM2(gene name)|psi-mi:TGM2(display_short)|uniprotkb:Tissue transglutaminase(gene name synonym)|uniprotkb:Transglutaminase C(gene name synonym)|uniprotkb:Transglutaminase-2(gene name synonym)|uniprotkb:Transglutaminase H(gene name synonym)|uniprotkb:Erythrocyte transglutaminase(gene name synonym)|uniprotkb:"Heart G alpha(h)"(gene name synonym)|uniprotkb:Isopeptidase TGM2(gene name synonym)|uniprotkb:"Protein G alpha(h)"(gene name synonym)|uniprotkb:Protein-glutamine deamidase TGM2(gene name synonym)|uniprotkb:Protein-glutamine dopaminyltransferase TGM2(gene name synonym)|uniprotkb:Protein-glutamine histaminyltransferase TGM2(gene name synonym)|uniprotkb:Protein-glutamine noradrenalinyltransferase TGM2(gene name synonym)|uniprotkb:Protein-glutamine serotonyltransferase TGM2(gene name synonym)|uniprotkb:Transglutaminase II(gene name synonym)	psi-mi:akp13_human(display_long)|uniprotkb:Protein kinase A-anchoring protein 13(gene name synonym)|uniprotkb:Breast cancer nuclear receptor-binding auxiliary protein(gene name synonym)|uniprotkb:Human thyroid-anchoring protein 31(gene name synonym)|uniprotkb:Guanine nucleotide exchange factor Lbc(gene name synonym)|uniprotkb:AKAP-Lbc(gene name synonym)|uniprotkb:p47(gene name synonym)|uniprotkb:Lymphoid blast crisis oncogene(gene name synonym)|uniprotkb:Non-oncogenic Rho GTPase-specific GTP exchange factor(gene name synonym)|uniprotkb:AKAP13(gene name)|psi-mi:AKAP13(display_short)|uniprotkb:BRX(gene name synonym)|uniprotkb:HT31(gene name synonym)|uniprotkb:LBC(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Lewis et al. (2005)	pubmed:16301118|imex:IM-19946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1373939|imex:IM-19946-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004604.2|refseq:NP_945189.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0018153"("isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine")|go:"GO:0018277"(protein deamination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031226"(intrinsic component of plasma membrane)|ensembl:ENSG00000198959(gene)|ensembl:ENST00000361475(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003810"(protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050568"(protein-glutamine glutaminase activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0060348"(bone development)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0120295"(histone serotonyltransferase activity)|go:"GO:0120297"(histone dopaminyltransferase activity)|go:"GO:0120298"(peptide noradrenalinyltransferase activity)|go:"GO:0120299"(peptide histaminyltransferase activity)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904015"(cellular response to serotonin)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|interpro:IPR001102(Transglutaminase, N-terminal)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR008958(Transglutaminase, C-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013808(Transglutaminase, conserved site)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR023608|interpro:IPR036238|interpro:IPR036985|interpro:IPR038765|mint:P21980|rcsb pdb:1FAU|rcsb pdb:1KV3|rcsb pdb:2Q3Z|rcsb pdb:3LY6|rcsb pdb:3S3J|rcsb pdb:3S3P|rcsb pdb:3S3S|rcsb pdb:4PYG|rcsb pdb:6A8P|rcsb pdb:6KZB|go:"GO:2000425"(regulation of apoptotic cell clearance)|refseq:XP_011527330.1|refseq:NP_001310245.1|dip:DIP-33557N	refseq:NP_006729.4|refseq:NP_009131.2|ensembl:ENST00000361243|ensembl:ENSP00000354718|ensembl:ENSP00000378026|ensembl:ENST00000560302|ensembl:ENSP00000453634|refseq:NP_001257475.1|dip:DIP-180N|ensembl:ENSG00000170776(gene)|ensembl:ENST00000394518(transcript)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051168"(nuclear export)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060348"(bone development)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0086023"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018459|interpro:IPR028852|interpro:IPR035899|interpro:IPR041020|mint:Q12802|rcsb pdb:2DRN|rcsb pdb:2LG1|rcsb pdb:4D0N|rcsb pdb:4D0O|rcsb pdb:6BCA|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106	omim:176807(primary-reference)	-	-	author-identifiers:BAIT gene BC050312|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/24	2014/10/16	rogid:S61on+x/CwI9G/k/0UhS6pFO+wE9606	rogid:pHHpKUh10J/O/fp06k4NaNhJF6U9606	intact-crc:EF04E68A538DBB8B|rigid:pTevzW6x9IrzfuHVsfguuypw7rI	false	sufficient binding region:269-687	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)