#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P51571	uniprotkb:Q03463	intact:EBI-1054539|uniprotkb:Q53XY1|uniprotkb:A8K378|ensembl:ENSP00000317331|ensembl:ENSP00000359103|ensembl:ENSP00000359104	intact:EBI-1266801	psi-mi:ssrd_human(display_long)|uniprotkb:Signal sequence receptor subunit delta(gene name synonym)|uniprotkb:SSR4(gene name)|psi-mi:SSR4(display_short)|uniprotkb:TRAPD(gene name synonym)	psi-mi:polg_hcvj1(display_long)	psi-mi:"MI:0018"(two hybrid)	Huang et al. (2005)	pubmed:16094715|imex:IM-19542|mint:MINT-6594466	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:421877(hcvj1)|taxid:421877("Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1266915|imex:IM-19542-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191455.1|refseq:NP_006271.1|refseq:XP_011529488.1|refseq:XP_011529489.1|ensembl:ENSG00000180879(gene)|ensembl:ENST00000320857(transcript)|ensembl:ENST00000370086(transcript)|ensembl:ENST00000370087(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008855(Translocon-associated)|mint:P51571|reactome:R-HSA-1799339	interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR024350|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|rcsb pdb:2KNU|rcsb pdb:3MRG|rcsb pdb:3MRH|rcsb pdb:3MRI|rcsb pdb:3MRJ|rcsb pdb:3MRL|interpro:IPR042205|interpro:IPR042209|interpro:IPR043502|interpro:IPR043504|interpro:IPR027417|interpro:IPR038170|interpro:IPR038568|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033648"(host intracellular membrane-bounded organelle)|go:"GO:0034125"(negative regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034156"(negative regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990216"(positive regulation by symbiont of host transcription)|interpro:IPR043128	-	-	-	figure legend:4, Table 1|comment:"The HCV genome has only one ORF which codes for a large polyprotein precursor.  This precursor is cleaved to generate at least 10 proteins including p7. The UniProtKB entry shows that p7 is located at aa 747-809 (by similarity)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/06/20	2014/10/16	rogid:2SNgZQH/jwi61UcuHUf7RYKZH589606	rogid:sB6yCcaXx3IQ4O37UvpVT2LgeV0421877	intact-crc:B1B3F17077CDDAD7|rigid:yxr+MiY08rx5uWNem7RBhDE8GSE	false	-	sufficient binding region:747-809	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q03463	uniprotkb:Q6UXK2	intact:EBI-1266801	intact:EBI-1266923|uniprotkb:A8K352|uniprotkb:Q9P263|ensembl:ENSP00000355402|ensembl:ENSP00000411443|ensembl:ENSP00000411834|ensembl:ENSP00000455531|ensembl:ENSP00000458080	psi-mi:polg_hcvj1(display_long)	psi-mi:islr2_human(display_long)|uniprotkb:ISLR2(gene name)|psi-mi:ISLR2(display_short)|uniprotkb:KIAA1465(gene name synonym)|uniprotkb:UNQ1885/PRO4329(orf name)|uniprotkb:LINX(gene name synonym)|uniprotkb:Leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Huang et al. (2005)	pubmed:16094715|imex:IM-19542|mint:MINT-6594466	taxid:421877(hcvj1)|taxid:421877("Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1266937|imex:IM-19542-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR024350|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|rcsb pdb:2KNU|rcsb pdb:3MRG|rcsb pdb:3MRH|rcsb pdb:3MRI|rcsb pdb:3MRJ|rcsb pdb:3MRL|interpro:IPR042205|interpro:IPR042209|interpro:IPR043502|interpro:IPR043504|interpro:IPR027417|interpro:IPR038170|interpro:IPR038568|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033648"(host intracellular membrane-bounded organelle)|go:"GO:0034125"(negative regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034156"(negative regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990216"(positive regulation by symbiont of host transcription)|interpro:IPR043128	refseq:NP_001123608.1|refseq:NP_001123609.1|refseq:NP_001123610.1|refseq:NP_065902.1|ensembl:ENSG00000167178|ensembl:ENSG00000167178|ensembl:ENSG00000167178|refseq:XP_011520142.1|refseq:XP_011520143.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR032675|interpro:IPR036179|ensembl:ENSG00000167178(gene)|ensembl:ENST00000361742(transcript)|ensembl:ENST00000435464(transcript)|ensembl:ENST00000453268(transcript)|ensembl:ENST00000565159(transcript)|ensembl:ENST00000565540(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045773"(positive regulation of axon extension)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)	-	-	-	figure legend:4, Table 1|comment:"The HCV genome has only one ORF which codes for a large polyprotein precursor.  This precursor is cleaved to generate at least 10 proteins including p7. The UniProtKB entry shows that p7 is located at aa 747-809 (by similarity)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/06/20	2014/10/16	rogid:sB6yCcaXx3IQ4O37UvpVT2LgeV0421877	rogid:XKLK4aSyKavF1Vdy1994aeDWCB89606	intact-crc:86061E520783C11E|rigid:Oyx6AEeftMEJ1W+LsRayzE6IYk4	false	sufficient binding region:747-809	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96SI9	uniprotkb:Q03463	intact:EBI-740355|uniprotkb:Q32NB9|uniprotkb:Q9BUE1|uniprotkb:Q9BXG4|uniprotkb:Q9H0B4|uniprotkb:Q9H7V1|uniprotkb:Q9NUK4|ensembl:ENSP00000321347|ensembl:ENSP00000415968	intact:EBI-1266801	psi-mi:strbp_human(display_long)|uniprotkb:STRBP(gene name)|psi-mi:STRBP(display_short)|uniprotkb:SPNR(gene name synonym)	psi-mi:polg_hcvj1(display_long)	psi-mi:"MI:0018"(two hybrid)	Huang et al. (2005)	pubmed:16094715|imex:IM-19542|mint:MINT-6594466	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:421877(hcvj1)|taxid:421877("Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1266952|imex:IM-19542-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001164608.1|refseq:NP_060857.2|ensembl:ENSG00000165209(gene)|ensembl:ENST00000348403(transcript)|ensembl:ENST00000447404(transcript)|go:"GO:0002177"(manchette)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0007638"(mechanosensory behavior)|go:"GO:0008017"(microtubule binding)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR030446|interpro:IPR043519|interpro:IPR044472|rcsb pdb:2DMY|refseq:XP_016870383.1|refseq:XP_016870384.1|refseq:XP_016870385.1	interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR024350|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|rcsb pdb:2KNU|rcsb pdb:3MRG|rcsb pdb:3MRH|rcsb pdb:3MRI|rcsb pdb:3MRJ|rcsb pdb:3MRL|interpro:IPR042205|interpro:IPR042209|interpro:IPR043502|interpro:IPR043504|interpro:IPR027417|interpro:IPR038170|interpro:IPR038568|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033648"(host intracellular membrane-bounded organelle)|go:"GO:0034125"(negative regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034156"(negative regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990216"(positive regulation by symbiont of host transcription)|interpro:IPR043128	-	-	-	figure legend:4, Table 1|comment:"The HCV genome has only one ORF which codes for a large polyprotein precursor.  This precursor is cleaved to generate at least 10 proteins including p7. The UniProtKB entry shows that p7 is located at aa 747-809 (by similarity)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/06/20	2014/10/16	rogid:xVEZqCqBcH0MBB1Ar9SU+9Yhsbs9606	rogid:sB6yCcaXx3IQ4O37UvpVT2LgeV0421877	intact-crc:9933000F5CDDB012|rigid:7rV9Ow/8eDH+fTIhtOVVTfAsYto	false	-	sufficient binding region:747-809	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9H2W1	uniprotkb:Q03463	intact:EBI-1266965|uniprotkb:F8W9K1|uniprotkb:Q8TBV7|uniprotkb:Q8TEZ4|uniprotkb:Q8TEZ5|uniprotkb:Q96PG6|uniprotkb:Q9H2L1|uniprotkb:Q9H2N3|uniprotkb:Q9H3V1|uniprotkb:Q9HC76|uniprotkb:A8K755|uniprotkb:Q7Z4E8|ensembl:ENSP00000436979	intact:EBI-1266801	psi-mi:m4a6a_human(display_long)|uniprotkb:MS4A6A(gene name)|psi-mi:MS4A6A(display_short)|uniprotkb:4SPAN3(gene name synonym)|uniprotkb:CD20L3(gene name synonym)|uniprotkb:MS4A6(gene name synonym)|uniprotkb:CDA01(orf name)|uniprotkb:Four-span transmembrane protein 3(gene name synonym)|uniprotkb:CD20 antigen-like 3(gene name synonym)|uniprotkb:MSTP090(orf name)	psi-mi:polg_hcvj1(display_long)	psi-mi:"MI:0018"(two hybrid)	Huang et al. (2005)	pubmed:16094715|imex:IM-19542|mint:MINT-6594466	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:421877(hcvj1)|taxid:421877("Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1266996|imex:IM-19542-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071744.2|refseq:NP_690590.1|refseq:NP_690591.1|refseq:NP_001234928.1|ensembl:ENSG00000110077(gene)|ensembl:ENST00000530839(transcript)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0016021"(integral component of membrane)|interpro:IPR007237(CD20/IgE Fc receptor beta subunit)|interpro:IPR030417|interpro:IPR030427	interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR024350|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|rcsb pdb:2KNU|rcsb pdb:3MRG|rcsb pdb:3MRH|rcsb pdb:3MRI|rcsb pdb:3MRJ|rcsb pdb:3MRL|interpro:IPR042205|interpro:IPR042209|interpro:IPR043502|interpro:IPR043504|interpro:IPR027417|interpro:IPR038170|interpro:IPR038568|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033648"(host intracellular membrane-bounded organelle)|go:"GO:0034125"(negative regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034156"(negative regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990216"(positive regulation by symbiont of host transcription)|interpro:IPR043128	-	-	-	figure legend:4, Table 1|comment:"The HCV genome has only one ORF which codes for a large polyprotein precursor.  This precursor is cleaved to generate at least 10 proteins including p7. The UniProtKB entry shows that p7 is located at aa 747-809 (by similarity)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/06/20	2014/10/16	rogid:grulmeEQHMF87IF9Ln1V6UsDx7c9606	rogid:sB6yCcaXx3IQ4O37UvpVT2LgeV0421877	intact-crc:0EB5379BD4D2BA45|rigid:f8UgGym/78S3EjB5oxzXvqsZ8tI	false	-	sufficient binding region:747-809	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-1267003	uniprotkb:Q03463	-	intact:EBI-1266801	psi-mi:agsk1_human(display_short)|psi-mi:EBI-1267003(display_long)	psi-mi:polg_hcvj1(display_long)	psi-mi:"MI:0018"(two hybrid)	Huang et al. (2005)	pubmed:16094715|imex:IM-19542|mint:MINT-6594466	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:421877(hcvj1)|taxid:421877("Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1267006|imex:IM-19542-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:Q9BXM8(uniprot-removed-ac)	interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR024350|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|rcsb pdb:2KNU|rcsb pdb:3MRG|rcsb pdb:3MRH|rcsb pdb:3MRI|rcsb pdb:3MRJ|rcsb pdb:3MRL|interpro:IPR042205|interpro:IPR042209|interpro:IPR043502|interpro:IPR043504|interpro:IPR027417|interpro:IPR038170|interpro:IPR038568|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033648"(host intracellular membrane-bounded organelle)|go:"GO:0034125"(negative regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034156"(negative regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990216"(positive regulation by symbiont of host transcription)|interpro:IPR043128	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:4, Table 1|comment:"The HCV genome has only one ORF which codes for a large polyprotein precursor.  This precursor is cleaved to generate at least 10 proteins including p7. The UniProtKB entry shows that p7 is located at aa 747-809 (by similarity)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/06/20	2014/10/16	rogid:why8fIPyf3K8sy3df03oq4h07RQ9606	rogid:sB6yCcaXx3IQ4O37UvpVT2LgeV0421877	intact-crc:9286EECC2F2F2309|rigid:fn5ewHbfm3xK/8AP9+5PenMX4Ro	false	-	sufficient binding region:747-809	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O95466	uniprotkb:Q03463	intact:EBI-720020|uniprotkb:Q6DKG5|uniprotkb:Q6IBP3|uniprotkb:Q86UH1|uniprotkb:Q8N671|uniprotkb:Q8TDH1|uniprotkb:Q96H10|ensembl:ENSP00000329219|uniprotkb:D2DGW2	intact:EBI-1266801	psi-mi:fmnl1_human(display_long)|uniprotkb:Leukocyte formin(gene name synonym)|uniprotkb:CLL-associated antigen KW-13(gene name synonym)|uniprotkb:FMNL1(gene name)|psi-mi:FMNL1(display_short)|uniprotkb:C17orf1(gene name synonym)|uniprotkb:C17orf1B(gene name synonym)|uniprotkb:FMNL(gene name synonym)|uniprotkb:FRL1(gene name synonym)	psi-mi:polg_hcvj1(display_long)	psi-mi:"MI:0018"(two hybrid)	Huang et al. (2005)	pubmed:16094715|imex:IM-19542|mint:MINT-6594466	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:421877(hcvj1)|taxid:421877("Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1267014|imex:IM-19542-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005883.2|ensembl:ENSG00000184922(gene)|ensembl:ENST00000331495(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032059"(bleb)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027657|interpro:IPR042201|interpro:IPR043592|mint:O95466|rcsb pdb:4YDH|reactome:R-HSA-5663220|reactome:R-HSA-9013148|reactome:R-HSA-9013149|refseq:XP_006722126.1|refseq:XP_006722133.1	interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR024350|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|rcsb pdb:2KNU|rcsb pdb:3MRG|rcsb pdb:3MRH|rcsb pdb:3MRI|rcsb pdb:3MRJ|rcsb pdb:3MRL|interpro:IPR042205|interpro:IPR042209|interpro:IPR043502|interpro:IPR043504|interpro:IPR027417|interpro:IPR038170|interpro:IPR038568|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033648"(host intracellular membrane-bounded organelle)|go:"GO:0034125"(negative regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034156"(negative regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990216"(positive regulation by symbiont of host transcription)|interpro:IPR043128	-	-	-	figure legend:4, Table 1|comment:"The HCV genome has only one ORF which codes for a large polyprotein precursor.  This precursor is cleaved to generate at least 10 proteins including p7. The UniProtKB entry shows that p7 is located at aa 747-809 (by similarity)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/06/20	2014/10/16	rogid:SN1xgeqb5yPUjiaEv2H/kyDrD4c9606	rogid:sB6yCcaXx3IQ4O37UvpVT2LgeV0421877	intact-crc:756F11427E57939B|rigid:EDNvnf86mUaSrRcyk3RhNjwh19c	false	-	sufficient binding region:747-809	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)