#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:17440"	uniprotkb:P18031	intact:EBI-1263351	intact:EBI-968788|ensembl:ENSP00000360683|uniprotkb:Q5TGD8|uniprotkb:Q9BQV9|uniprotkb:Q9NQQ4	psi-mi:4-nitrophenyl dihydrogen phosphate(display_short)|psi-mi:"CHEBI:17440"(display_long)	psi-mi:ptn1_human(display_long)|uniprotkb:PTPN1(gene name)|psi-mi:PTPN1(display_short)|uniprotkb:PTP1B(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1B(gene name synonym)	psi-mi:"MI:0434"(phosphatase assay)	Horn et al. (2005)	pubmed:15896299|imex:IM-19728|mint:MINT-6672560	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1263352|imex:IM-19728-6	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000196396(gene)|ensembl:ENST00000371621(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0097443"(sorting endosome)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:1902202"(regulation of hepatocyte growth factor receptor signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012265(Protein-tyrosine phosphatase, non-receptor type-1, -2)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:P18031|rcsb pdb:1A5Y|rcsb pdb:1BZC|rcsb pdb:1BZH|rcsb pdb:1BZJ|rcsb pdb:1C83|rcsb pdb:1C84|rcsb pdb:1C85|rcsb pdb:1C86|rcsb pdb:1C87|rcsb pdb:1C88|rcsb pdb:1ECV|rcsb pdb:1EEN|rcsb pdb:1EEO|rcsb pdb:1G1F|rcsb pdb:1AAX|rcsb pdb:1G1G|rcsb pdb:1G1H|rcsb pdb:1G7F|rcsb pdb:1G7G|rcsb pdb:1GFY|rcsb pdb:1I57|rcsb pdb:1JF7|rcsb pdb:5QFV|rcsb pdb:5QFW|rcsb pdb:5QFX|rcsb pdb:5QFY|rcsb pdb:5QFZ|rcsb pdb:5QG0|rcsb pdb:5QG1|rcsb pdb:5QG2|rcsb pdb:5QG3|rcsb pdb:5QG4|rcsb pdb:5QG5|rcsb pdb:5QG6|rcsb pdb:5QG7|rcsb pdb:5QG8|rcsb pdb:5QG9|rcsb pdb:5QGA|rcsb pdb:5QGB|rcsb pdb:5QGC|rcsb pdb:5QGD|rcsb pdb:5QGE|rcsb pdb:5QGF|rcsb pdb:5T19|rcsb pdb:6B8E|rcsb pdb:6B8T|rcsb pdb:6B8X|rcsb pdb:6B8Z|rcsb pdb:6B90|rcsb pdb:6B95|rcsb pdb:6BAI|rcsb pdb:6CWU|rcsb pdb:6CWV|rcsb pdb:6NTP|rcsb pdb:6OL4|rcsb pdb:6OLQ|rcsb pdb:6OLV|rcsb pdb:1KAK|rcsb pdb:1KAV|rcsb pdb:1L8G|rcsb pdb:1LQF|rcsb pdb:1NL9|rcsb pdb:1NNY|rcsb pdb:1NO6|rcsb pdb:1NWE|rcsb pdb:1NWL|rcsb pdb:1NZ7|rcsb pdb:1OEM|rcsb pdb:1OEO|rcsb pdb:1OES|rcsb pdb:1OET|rcsb pdb:1OEU|rcsb pdb:1OEV|rcsb pdb:1ONY|rcsb pdb:1ONZ|rcsb pdb:1PA1|rcsb pdb:1PH0|rcsb pdb:1PTT|rcsb pdb:1PTU|rcsb pdb:1PTV|rcsb pdb:1PTY|rcsb pdb:1PXH|rcsb pdb:1PYN|rcsb pdb:1Q1M|rcsb pdb:1Q6J|rcsb pdb:1Q6M|rcsb pdb:1Q6N|rcsb pdb:1Q6P|rcsb pdb:1Q6S|rcsb pdb:1Q6T|rcsb pdb:1QXK|rcsb pdb:1SUG|rcsb pdb:1T48|rcsb pdb:1T49|rcsb pdb:1T4J|rcsb pdb:1WAX|rcsb pdb:1XBO|rcsb pdb:2AZR|rcsb pdb:2B07|rcsb pdb:2B4S|rcsb pdb:2BGD|rcsb pdb:2NT7|rcsb pdb:2BGE|rcsb pdb:2CM2|rcsb pdb:2NTA|rcsb pdb:2CM3|rcsb pdb:2CM7|rcsb pdb:2QBP|rcsb pdb:2CM8|rcsb pdb:2CMA|rcsb pdb:2QBQ|rcsb pdb:2QBR|rcsb pdb:2CMB|rcsb pdb:2CMC|rcsb pdb:2CNE|rcsb pdb:2QBS|rcsb pdb:2CNF|rcsb pdb:2CNG|rcsb pdb:2CNH|rcsb pdb:2CNI|rcsb pdb:2F6F|rcsb pdb:2F6T|rcsb pdb:2VEU|rcsb pdb:2F6V|rcsb pdb:2F6W|rcsb pdb:2F6Y|rcsb pdb:2VEV|rcsb pdb:2VEW|rcsb pdb:2VEX|rcsb pdb:2VEY|rcsb pdb:2F6Z|rcsb pdb:2ZMM|rcsb pdb:2F70|rcsb pdb:2F71|rcsb pdb:2ZN7|rcsb pdb:3A5J|rcsb pdb:2FJM|rcsb pdb:2FJN|rcsb pdb:2H4G|rcsb pdb:2H4K|rcsb pdb:2HB1|rcsb pdb:2HNP|rcsb pdb:2HNQ|rcsb pdb:3A5K|rcsb pdb:3CWE|rcsb pdb:6OMY|rcsb pdb:3D9C|rcsb pdb:3EAX|rcsb pdb:4QAP|rcsb pdb:4QBE|rcsb pdb:3EB1|rcsb pdb:4QBW|rcsb pdb:4Y14|rcsb pdb:4ZRT|rcsb pdb:5K9V|rcsb pdb:5K9W|rcsb pdb:5KA0|rcsb pdb:5KA1|rcsb pdb:5KA2|rcsb pdb:5KA3|rcsb pdb:5KA4|rcsb pdb:5KA7|rcsb pdb:5KA8|rcsb pdb:5KA9|rcsb pdb:5KAA|rcsb pdb:5KAB|rcsb pdb:5KAC|rcsb pdb:5KAD|rcsb pdb:5QDE|rcsb pdb:5QDF|rcsb pdb:5QDG|rcsb pdb:5QDH|rcsb pdb:5QDI|rcsb pdb:5QDJ|rcsb pdb:5QDK|rcsb pdb:5QDL|rcsb pdb:5QDM|rcsb pdb:5QDN|rcsb pdb:3EU0|rcsb pdb:3I7Z|rcsb pdb:3I80|rcsb pdb:3QKP|rcsb pdb:3QKQ|rcsb pdb:3SME|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:3ZV2|rcsb pdb:4BJO|rcsb pdb:4I8N|rcsb pdb:4QAH|rcsb pdb:5QDO|rcsb pdb:5QDP|rcsb pdb:5QDQ|rcsb pdb:5QDR|rcsb pdb:5QDS|rcsb pdb:6PG0|rcsb pdb:6PGT|rcsb pdb:6PHA|rcsb pdb:6PHS|rcsb pdb:6PM8|rcsb pdb:6W30|rcsb pdb:7KEN|rcsb pdb:7L0C|rcsb pdb:7L0H|rcsb pdb:7LFO|rcsb pdb:7MM1|reactome:R-HSA-354192|reactome:R-HSA-6807004|reactome:R-HSA-877312|reactome:R-HSA-8849472|reactome:R-HSA-9022699|reactome:R-HSA-912694|reactome:R-HSA-982772|rcsb pdb:6PFW|rcsb pdb:5QDW|rcsb pdb:5QDX|rcsb pdb:5QDY|rcsb pdb:5QDZ|rcsb pdb:5QE0|rcsb pdb:5QE1|rcsb pdb:5QDT|rcsb pdb:5QDU|rcsb pdb:5QE2|rcsb pdb:5QE3|rcsb pdb:5QE4|rcsb pdb:5QE5|rcsb pdb:5QE6|rcsb pdb:5QE7|rcsb pdb:5QE8|rcsb pdb:5QE9|rcsb pdb:5QEA|rcsb pdb:5QEB|rcsb pdb:5QEC|rcsb pdb:5QED|rcsb pdb:5QEE|rcsb pdb:5QEF|rcsb pdb:5QEG|rcsb pdb:5QEH|rcsb pdb:5QEI|rcsb pdb:5QEJ|rcsb pdb:5QDV|rcsb pdb:5QEK|rcsb pdb:5QEL|rcsb pdb:5QEM|rcsb pdb:5QEN|rcsb pdb:5QEO|rcsb pdb:5QEP|rcsb pdb:5QEQ|rcsb pdb:5QER|rcsb pdb:5QES|rcsb pdb:5QET|rcsb pdb:5QEU|rcsb pdb:5QEV|rcsb pdb:5QEW|rcsb pdb:5QEX|rcsb pdb:5QEY|rcsb pdb:5QEZ|rcsb pdb:5QF0|rcsb pdb:5QF1|rcsb pdb:5QF2|rcsb pdb:5QF3|rcsb pdb:5QF4|rcsb pdb:5QF5|rcsb pdb:5QF6|rcsb pdb:5QF7|rcsb pdb:5QF8|rcsb pdb:5QF9|rcsb pdb:5QFA|rcsb pdb:5QFB|rcsb pdb:5QFC|rcsb pdb:5QFD|rcsb pdb:5QFE|rcsb pdb:5QFF|rcsb pdb:5QFG|rcsb pdb:5QFH|rcsb pdb:5QFI|rcsb pdb:5QFJ|rcsb pdb:5QFK|rcsb pdb:5QFL|rcsb pdb:5QFM|rcsb pdb:5QFN|rcsb pdb:5QFO|rcsb pdb:5QFP|rcsb pdb:5QFQ|rcsb pdb:5QFR|rcsb pdb:5QFS|rcsb pdb:5QFT|rcsb pdb:5QFU|refseq:NP_001265547.1|refseq:NP_002818.1|dip:DIP-38014N	-	-	-	figure legend:4|agonist:"DTT - the presence of DTT (2.0 E-4 M or 5.0 E-4 M) stimulates the phosphatase activity of PTP1B."|agonist:"EDTA - the presence of EDTA (1.0 E-3 M or 2.0 E-3 M) stimulates the phosphatase activity of PTP1B."|antagonist:"ZnCl2 - the presence of ZnCl2 (5.0 E-2 M or 1.0 E-1 M) inhibits the phosphatase activity of PTP1B."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/06/11	2014/10/16	-	rogid:yz+WjBWu7IXrpAfeMUJ2s0e0ACM9606	intact-crc:6977FB9CD8688E89	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14939	intact:EBI-1263369	intact:EBI-1053996|uniprotkb:O43540|uniprotkb:O43579|uniprotkb:O43580|uniprotkb:Q96BY3|uniprotkb:Q6PGR0|ensembl:ENSP00000263088|uniprotkb:I3L2C9	-	psi-mi:pld2_human(display_long)|uniprotkb:Choline phosphatase 2(gene name synonym)|uniprotkb:Phosphatidylcholine-hydrolyzing phospholipase D2(gene name synonym)|uniprotkb:PLD1C(gene name synonym)|uniprotkb:PLD2(gene name)|psi-mi:PLD2(display_short)	psi-mi:grb2_cerae_protein(display_short)|psi-mi:EBI-1263369(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Horn et al. (2005)	pubmed:15896299|imex:IM-19728|mint:MINT-6672560	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1263378|imex:IM-19728-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230037.1|refseq:NP_002654.3|ensembl:ENSG00000129219(gene)|ensembl:ENST00000263088(transcript)|go:"GO:0004630"(phospholipase D activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0048017"(inositol lipid-mediated signaling)|go:"GO:0048870"(cell motility)|go:"GO:0070290"(N-acylphosphatidylethanolamine-specific phospholipase D activity)|go:"GO:0098793"(presynapse)|interpro:IPR001683(Phox-like)|interpro:IPR001736(Phospholipase D/Transphosphatidylase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015679(Phospholipase D)|interpro:IPR016555(Phospholipase D, eukaryota)|interpro:IPR025202|interpro:IPR036871|mint:O14939|rcsb pdb:6OHM|rcsb pdb:6OHO|rcsb pdb:6OHP|rcsb pdb:6OHQ|rcsb pdb:6OHS|reactome:R-HSA-1483148|reactome:R-HSA-1483166|reactome:R-HSA-2029485|reactome:R-HSA-9013149|reactome:R-HSA-9013404|dip:DIP-38903N	-	-	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Similar to P62993	figure legend:8 A|delivery method:O14939 transfection|expression level:O14939 over-expressed|agonist:Grb2 - addition of recombinant Grb2 to the lysates prior to immunoprecipitation stimulated the interaction.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2007/06/11	2014/10/16	rogid:uQUYSNYIk5D3fQ8oB/67Oo2/eOE9606	-	intact-crc:66F7D3AE5B0224A9	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-1263375	intact:EBI-1263369	-	-	psi-mi:ptpn1_cerae_protein(display_short)|psi-mi:EBI-1263375(display_long)	psi-mi:grb2_cerae_protein(display_short)|psi-mi:EBI-1263369(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Horn et al. (2005)	pubmed:15896299|imex:IM-19728|mint:MINT-6672560	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1263389|imex:IM-19728-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	-	intact:EBI-1263395(intact-secondary)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Similar to P18031	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Similar to P62993	figure legend:9 A|agonist:PTP1B - addition of recombinant PTP1B to the lysates prior to immunoprecipitation stimulated the interaction.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2007/06/11	2014/10/16	-	-	intact-crc:57DA365DE8AC9D81	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14939	intact:EBI-1263375	intact:EBI-1053996|uniprotkb:O43540|uniprotkb:O43579|uniprotkb:O43580|uniprotkb:Q96BY3|uniprotkb:Q6PGR0|ensembl:ENSP00000263088|uniprotkb:I3L2C9	-	psi-mi:pld2_human(display_long)|uniprotkb:Choline phosphatase 2(gene name synonym)|uniprotkb:Phosphatidylcholine-hydrolyzing phospholipase D2(gene name synonym)|uniprotkb:PLD1C(gene name synonym)|uniprotkb:PLD2(gene name)|psi-mi:PLD2(display_short)	psi-mi:ptpn1_cerae_protein(display_short)|psi-mi:EBI-1263375(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Horn et al. (2005)	pubmed:15896299|imex:IM-19728|mint:MINT-6672560	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1263401|imex:IM-19728-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230037.1|refseq:NP_002654.3|ensembl:ENSG00000129219(gene)|ensembl:ENST00000263088(transcript)|go:"GO:0004630"(phospholipase D activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0048017"(inositol lipid-mediated signaling)|go:"GO:0048870"(cell motility)|go:"GO:0070290"(N-acylphosphatidylethanolamine-specific phospholipase D activity)|go:"GO:0098793"(presynapse)|interpro:IPR001683(Phox-like)|interpro:IPR001736(Phospholipase D/Transphosphatidylase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015679(Phospholipase D)|interpro:IPR016555(Phospholipase D, eukaryota)|interpro:IPR025202|interpro:IPR036871|mint:O14939|rcsb pdb:6OHM|rcsb pdb:6OHO|rcsb pdb:6OHP|rcsb pdb:6OHQ|rcsb pdb:6OHS|reactome:R-HSA-1483148|reactome:R-HSA-1483166|reactome:R-HSA-2029485|reactome:R-HSA-9013149|reactome:R-HSA-9013404|dip:DIP-38903N	-	-	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Similar to P18031	figure legend:9 B|agonist:PTP1B - addition of recombinant PTP1B to the lysates prior to immunoprecipitation stimulated the interaction.|delivery method:O14939 transfection|expression level:O14939 over-expressed|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2007/06/11	2014/10/16	rogid:uQUYSNYIk5D3fQ8oB/67Oo2/eOE9606	-	intact-crc:6F44112E235BF889	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-1263369	uniprotkb:O14939	-	intact:EBI-1053996|uniprotkb:O43540|uniprotkb:O43579|uniprotkb:O43580|uniprotkb:Q96BY3|uniprotkb:Q6PGR0|ensembl:ENSP00000263088|uniprotkb:I3L2C9	psi-mi:grb2_cerae_protein(display_short)|psi-mi:EBI-1263369(display_long)	psi-mi:pld2_human(display_long)|uniprotkb:Choline phosphatase 2(gene name synonym)|uniprotkb:Phosphatidylcholine-hydrolyzing phospholipase D2(gene name synonym)|uniprotkb:PLD1C(gene name synonym)|uniprotkb:PLD2(gene name)|psi-mi:PLD2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Horn et al. (2005)	pubmed:15896299|imex:IM-19728|mint:MINT-6672560	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1263421|imex:IM-19728-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001230037.1|refseq:NP_002654.3|ensembl:ENSG00000129219(gene)|ensembl:ENST00000263088(transcript)|go:"GO:0004630"(phospholipase D activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0048017"(inositol lipid-mediated signaling)|go:"GO:0048870"(cell motility)|go:"GO:0070290"(N-acylphosphatidylethanolamine-specific phospholipase D activity)|go:"GO:0098793"(presynapse)|interpro:IPR001683(Phox-like)|interpro:IPR001736(Phospholipase D/Transphosphatidylase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015679(Phospholipase D)|interpro:IPR016555(Phospholipase D, eukaryota)|interpro:IPR025202|interpro:IPR036871|mint:O14939|rcsb pdb:6OHM|rcsb pdb:6OHO|rcsb pdb:6OHP|rcsb pdb:6OHQ|rcsb pdb:6OHS|reactome:R-HSA-1483148|reactome:R-HSA-1483166|reactome:R-HSA-2029485|reactome:R-HSA-9013149|reactome:R-HSA-9013404|dip:DIP-38903N	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Similar to P62993	-	figure legend:8 B|delivery method:O14939 transfection|expression level:O14939 over-expressed|agonist:Grb2 - addition of recombinant Grb2 to the lysates prior to immunoprecipitation stimulated the interaction.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2007/06/11	2014/10/16	-	rogid:uQUYSNYIk5D3fQ8oB/67Oo2/eOE9606	intact-crc:FB43C25AED196ABC	false	-	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14939	intact:EBI-1263375	intact:EBI-1053996|uniprotkb:O43540|uniprotkb:O43579|uniprotkb:O43580|uniprotkb:Q96BY3|uniprotkb:Q6PGR0|ensembl:ENSP00000263088|uniprotkb:I3L2C9	-	psi-mi:pld2_human(display_long)|uniprotkb:Choline phosphatase 2(gene name synonym)|uniprotkb:Phosphatidylcholine-hydrolyzing phospholipase D2(gene name synonym)|uniprotkb:PLD1C(gene name synonym)|uniprotkb:PLD2(gene name)|psi-mi:PLD2(display_short)	psi-mi:ptpn1_cerae_protein(display_short)|psi-mi:EBI-1263375(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Horn et al. (2005)	pubmed:15896299|imex:IM-19728|mint:MINT-6672560	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1263431|imex:IM-19728-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230037.1|refseq:NP_002654.3|ensembl:ENSG00000129219(gene)|ensembl:ENST00000263088(transcript)|go:"GO:0004630"(phospholipase D activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0048017"(inositol lipid-mediated signaling)|go:"GO:0048870"(cell motility)|go:"GO:0070290"(N-acylphosphatidylethanolamine-specific phospholipase D activity)|go:"GO:0098793"(presynapse)|interpro:IPR001683(Phox-like)|interpro:IPR001736(Phospholipase D/Transphosphatidylase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015679(Phospholipase D)|interpro:IPR016555(Phospholipase D, eukaryota)|interpro:IPR025202|interpro:IPR036871|mint:O14939|rcsb pdb:6OHM|rcsb pdb:6OHO|rcsb pdb:6OHP|rcsb pdb:6OHQ|rcsb pdb:6OHS|reactome:R-HSA-1483148|reactome:R-HSA-1483166|reactome:R-HSA-2029485|reactome:R-HSA-9013149|reactome:R-HSA-9013404|dip:DIP-38903N	-	-	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Similar to P18031	figure legend:9 B|agonist:PTP1B - addition of recombinant PTP1B to the lysates prior to immunoprecipitation stimulated the interaction.|delivery method:O14939 transfection|expression level:O14939 over-expressed|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2007/06/11	2014/10/16	rogid:uQUYSNYIk5D3fQ8oB/67Oo2/eOE9606	-	intact-crc:53439826BBC67EFC	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)