#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P38328	uniprotkb:P47117	intact:EBI-2777|uniprotkb:D6VQN0|ensemblfungi:YBR234C	intact:EBI-2933|uniprotkb:D6VWN6|ensemblfungi:YJR065C	psi-mi:arpc1_yeast(display_long)|uniprotkb:ARC40(gene name)|psi-mi:ARC40(display_short)|uniprotkb:YBR234C(locus name)|uniprotkb:YBR1532(orf name)|uniprotkb:Arp2/3 complex 41 kDa subunit(gene name synonym)|uniprotkb:p41-ARC(gene name synonym)	psi-mi:arp3_yeast(display_long)|uniprotkb:ARP3(gene name)|psi-mi:ARP3(display_short)|uniprotkb:ACT4(gene name synonym)|uniprotkb:YJR065C(locus name)|uniprotkb:J1760(orf name)|uniprotkb:Actin-like protein ARP3(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Pan et al. (2004)	pubmed:15485833	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1249366	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000438|refseq:NP_009793.1|dip:DIP-2219N|mint:P38328|ensemblfungi:YBR234C(gene)|ensemblfungi:YBR234C_mRNA(transcript)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0030479"(actin cortical patch)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044396"(actin cortical patch organization)|go:"GO:0051015"(actin filament binding)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017383(Actin-related protein 2/3 complex, subunit 1)|interpro:IPR036322|reactome:R-SCE-2029482|reactome:R-SCE-5663213|reactome:R-SCE-8856828	sgd:S000003826|refseq:NP_012599.3|dip:DIP-2649N|mint:P47117|ensemblfungi:YJR065C(gene)|ensemblfungi:YJR065C_mRNA(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0030479"(actin cortical patch)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0044396"(actin cortical patch organization)|interpro:IPR004000(Actin/actin-like)|interpro:IPR015623(Actin-related protein 3)|interpro:IPR020902|interpro:IPR043129|reactome:R-SCE-2029482|reactome:R-SCE-5663213|reactome:R-SCE-8856828	-	crc64:D75C6BB8EC35EEDF	crc64:5BBD87E83F476E9F	figure legend:1	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/05/02	2014/10/16	rogid:SDFaDFaJRhwZT02o7w/XmITMZgI559292	rogid:zQX5F88/vot1WLMuLvVXxFh8aBk559292	intact-crc:536267D90ADD3A42|rigid:vhp9vfstUuV0U9FFFfq6HnxAVuI	false	-	calmodulin binding peptide plus protein a tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P38328	uniprotkb:Q12446	intact:EBI-2777|uniprotkb:D6VQN0|ensemblfungi:YBR234C	intact:EBI-10022|uniprotkb:D6W2N7|ensemblfungi:YOR181W	psi-mi:arpc1_yeast(display_long)|uniprotkb:ARC40(gene name)|psi-mi:ARC40(display_short)|uniprotkb:YBR234C(locus name)|uniprotkb:YBR1532(orf name)|uniprotkb:Arp2/3 complex 41 kDa subunit(gene name synonym)|uniprotkb:p41-ARC(gene name synonym)	psi-mi:las17_yeast(display_long)|uniprotkb:LAS17(gene name)|psi-mi:LAS17(display_short)|uniprotkb:YOR181W(locus name)	psi-mi:"MI:0096"(pull down)	Pan et al. (2004)	pubmed:15485833	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1249379	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000438|refseq:NP_009793.1|dip:DIP-2219N|mint:P38328|ensemblfungi:YBR234C(gene)|ensemblfungi:YBR234C_mRNA(transcript)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0030479"(actin cortical patch)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044396"(actin cortical patch organization)|go:"GO:0051015"(actin filament binding)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017383(Actin-related protein 2/3 complex, subunit 1)|interpro:IPR036322|reactome:R-SCE-2029482|reactome:R-SCE-5663213|reactome:R-SCE-8856828	refseq:NP_014824.1|sgd:S000005707|ensemblfungi:YOR181W(gene)|ensemblfungi:YOR181W_mRNA(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007015"(actin filament organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030479"(actin cortical patch)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0043332"(mating projection tip)|go:"GO:0045010"(actin nucleation)|go:"GO:0051666"(actin cortical patch localization)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0140224"(SLAC complex)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|rcsb pdb:1ZUK|dip:DIP-963N|mint:Q12446	-	crc64:D75C6BB8EC35EEDF	crc64:4488355563AA2645	figure legend:3A|author-identifiers:"Bait protein: Bee1;"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/05/02	2014/10/16	rogid:SDFaDFaJRhwZT02o7w/XmITMZgI559292	rogid:TfQ256gBQPp1T8Ntu2AvktFnypA559292	intact-crc:C46878D7023B00D9|rigid:qhOnCkUkFsuIGfDKBhmq+qvzrlo	false	his tag:?-?|ha tag:?-?	sufficient binding region:?-?|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q04439	uniprotkb:P38328	intact:EBI-11687|ensemblfungi:YMR109W|uniprotkb:D6VZT2	intact:EBI-2777|uniprotkb:D6VQN0|ensemblfungi:YBR234C	psi-mi:myo5_yeast(display_long)|uniprotkb:MYO5(gene name)|psi-mi:MYO5(display_short)|uniprotkb:YMR109W(locus name)|uniprotkb:YM9718.08(orf name)|uniprotkb:Class I unconventional myosin MYO5(gene name synonym)|uniprotkb:Type I myosin MYO5(gene name synonym)|uniprotkb:Actin-dependent myosin-I MYO5(gene name synonym)	psi-mi:arpc1_yeast(display_long)|uniprotkb:ARC40(gene name)|psi-mi:ARC40(display_short)|uniprotkb:YBR234C(locus name)|uniprotkb:YBR1532(orf name)|uniprotkb:Arp2/3 complex 41 kDa subunit(gene name synonym)|uniprotkb:p41-ARC(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pan et al. (2004)	pubmed:15485833	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1249393	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YMR109W_mRNA(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005933"(cellular bud)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007015"(actin filament organization)|go:"GO:0007121"(bipolar cellular bud site selection)|go:"GO:0009651"(response to salt stress)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030479"(actin cortical patch)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031982"(vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0051015"(actin filament binding)|go:"GO:0051286"(cell tip)|go:"GO:0051666"(actin cortical patch localization)|go:"GO:0071944"(cell periphery)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001452(Src homology-3)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR010926(Myosin tail 2)|interpro:IPR027417|interpro:IPR035535|ensemblfungi:YMR109W(gene)|interpro:IPR036028|interpro:IPR036072|interpro:IPR036961|rcsb pdb:1YP5|rcsb pdb:1ZUY|refseq:NP_013827.1|sgd:S000004715|mint:Q04439|dip:DIP-2222N	sgd:S000000438|refseq:NP_009793.1|dip:DIP-2219N|mint:P38328|ensemblfungi:YBR234C(gene)|ensemblfungi:YBR234C_mRNA(transcript)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0030479"(actin cortical patch)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044396"(actin cortical patch organization)|go:"GO:0051015"(actin filament binding)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017383(Actin-related protein 2/3 complex, subunit 1)|interpro:IPR036322|reactome:R-SCE-2029482|reactome:R-SCE-5663213|reactome:R-SCE-8856828	-	crc64:DFFB9EC16B61CD29	crc64:D75C6BB8EC35EEDF	figure legend:3A	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/05/02	2014/10/16	rogid:n/Po/L9Xd7LP+fY39QaqP/s5US4559292	rogid:SDFaDFaJRhwZT02o7w/XmITMZgI559292	intact-crc:37AB31A137357E6E|rigid:hvajvy/aypgTkcHqWZRDMmTvGa0	false	glutathione s tranferase tag:?-?|sufficient binding region:?-?	his tag:?-?|ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00401	uniprotkb:P38328	intact:EBI-957615|ensembl:ENSP00000223023|uniprotkb:Q7Z746|uniprotkb:A1JUI9	intact:EBI-2777|uniprotkb:D6VQN0|ensemblfungi:YBR234C	psi-mi:wasl_human(display_long)|uniprotkb:WASL(gene name)|psi-mi:WASL(display_short)	psi-mi:arpc1_yeast(display_long)|uniprotkb:ARC40(gene name)|psi-mi:ARC40(display_short)|uniprotkb:YBR234C(locus name)|uniprotkb:YBR1532(orf name)|uniprotkb:Arp2/3 complex 41 kDa subunit(gene name synonym)|uniprotkb:p41-ARC(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pan et al. (2004)	pubmed:15485833	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1249407	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0009617"(response to bacterium)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030478"(actin cap)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|rcsb pdb:2FF3|rcsb pdb:2LNH|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|rcsb pdb:2VCP|rcsb pdb:4CC2|rcsb pdb:4CC7|reactome:R-HSA-2029482|reactome:R-HSA-203641|reactome:R-HSA-373753|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013424|reactome:R-HSA-9664422|ensembl:ENSG00000106299(gene)|ensembl:ENST00000223023(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0051301"(cell division)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936|mint:O00401|go:"GO:0005634"(nucleus)|refseq:NP_003932.3|dip:DIP-29042N	sgd:S000000438|refseq:NP_009793.1|dip:DIP-2219N|mint:P38328|ensemblfungi:YBR234C(gene)|ensemblfungi:YBR234C_mRNA(transcript)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0030479"(actin cortical patch)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044396"(actin cortical patch organization)|go:"GO:0051015"(actin filament binding)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017383(Actin-related protein 2/3 complex, subunit 1)|interpro:IPR036322|reactome:R-SCE-2029482|reactome:R-SCE-5663213|reactome:R-SCE-8856828	-	-	crc64:D75C6BB8EC35EEDF	figure legend:3A, 3B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/05/02	2015/11/16	rogid:PinEPh47IRuCgiaJJZqStRhIAGQ9606	rogid:SDFaDFaJRhwZT02o7w/XmITMZgI559292	intact-crc:73C30BCF6824604F|rigid:jliFTigytqlcCaG88WShmSqREu4	false	mutation decreasing interaction:503-503|glutathione s tranferase tag:?-?|sufficient binding region:392..392-505..505	his tag:?-?|ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32381	uniprotkb:P47117	intact:EBI-2927|uniprotkb:D6VRW3|ensemblfungi:YDL029W	intact:EBI-2933|uniprotkb:D6VWN6|ensemblfungi:YJR065C	psi-mi:arp2_yeast(display_long)|uniprotkb:ACT2(gene name synonym)|uniprotkb:YDL029W(locus name)|uniprotkb:D2778(orf name)|uniprotkb:ARP2(gene name)|psi-mi:ARP2(display_short)|uniprotkb:Actin-like protein ARP2(gene name synonym)	psi-mi:arp3_yeast(display_long)|uniprotkb:ARP3(gene name)|psi-mi:ARP3(display_short)|uniprotkb:ACT4(gene name synonym)|uniprotkb:YJR065C(locus name)|uniprotkb:J1760(orf name)|uniprotkb:Actin-like protein ARP3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Pan et al. (2004)	pubmed:15485833	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1249890	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010255.1|sgd:S000002187|dip:DIP-2217N|mint:P32381|ensemblfungi:YDL029W(gene)|ensemblfungi:YDL029W_mRNA(transcript)|go:"GO:0000001"(mitochondrion inheritance)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030476"(ascospore wall assembly)|go:"GO:0030479"(actin cortical patch)|go:"GO:0032258"(cytoplasm to vacuole transport by the Cvt pathway)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0044396"(actin cortical patch organization)|go:"GO:0051654"(establishment of mitochondrion localization)|interpro:IPR004000(Actin/actin-like)|interpro:IPR020902|interpro:IPR043129|reactome:R-SCE-2029482|reactome:R-SCE-5663213|reactome:R-SCE-6798695|reactome:R-SCE-8856828	sgd:S000003826|refseq:NP_012599.3|dip:DIP-2649N|mint:P47117|ensemblfungi:YJR065C(gene)|ensemblfungi:YJR065C_mRNA(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0030479"(actin cortical patch)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0044396"(actin cortical patch organization)|interpro:IPR004000(Actin/actin-like)|interpro:IPR015623(Actin-related protein 3)|interpro:IPR020902|interpro:IPR043129|reactome:R-SCE-2029482|reactome:R-SCE-5663213|reactome:R-SCE-8856828	-	crc64:4C9E8952B477A1B9	crc64:5BBD87E83F476E9F	figure legend:5|comment:Complexes forms in strains in which Arc40 has been deleted, but Arp2 is less strongly associated within it.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/05/02	2014/10/16	rogid:baSDcw/PZH3Z8YHhIcYqtlNO3mw559292	rogid:zQX5F88/vot1WLMuLvVXxFh8aBk559292	intact-crc:4DF03464A0EFA701|rigid:McNiSPV2vmz7f8C16k3ik/XCOCY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32381	uniprotkb:Q05933	intact:EBI-2927|uniprotkb:D6VRW3|ensemblfungi:YDL029W	intact:EBI-2764|uniprotkb:D6VZ07|ensemblfungi:YLR370C	psi-mi:arp2_yeast(display_long)|uniprotkb:ACT2(gene name synonym)|uniprotkb:YDL029W(locus name)|uniprotkb:D2778(orf name)|uniprotkb:ARP2(gene name)|psi-mi:ARP2(display_short)|uniprotkb:Actin-like protein ARP2(gene name synonym)	psi-mi:arpc3_yeast(display_long)|uniprotkb:ARC18(gene name)|psi-mi:ARC18(display_short)|uniprotkb:YLR370C(locus name)|uniprotkb:L8039.15(orf name)|uniprotkb:Arp2/3 complex 21 kDa subunit(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Pan et al. (2004)	pubmed:15485833	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1249890	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010255.1|sgd:S000002187|dip:DIP-2217N|mint:P32381|ensemblfungi:YDL029W(gene)|ensemblfungi:YDL029W_mRNA(transcript)|go:"GO:0000001"(mitochondrion inheritance)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030476"(ascospore wall assembly)|go:"GO:0030479"(actin cortical patch)|go:"GO:0032258"(cytoplasm to vacuole transport by the Cvt pathway)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0044396"(actin cortical patch organization)|go:"GO:0051654"(establishment of mitochondrion localization)|interpro:IPR004000(Actin/actin-like)|interpro:IPR020902|interpro:IPR043129|reactome:R-SCE-2029482|reactome:R-SCE-5663213|reactome:R-SCE-6798695|reactome:R-SCE-8856828	sgd:S000004362|refseq:NP_013474.3|dip:DIP-2218N|mint:Q05933|ensemblfungi:YLR370C(gene)|ensemblfungi:YLR370C_mRNA(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0044396"(actin cortical patch organization)|go:"GO:0051654"(establishment of mitochondrion localization)|interpro:IPR007204(ARP2/3 complex, 21 kDa p21-Arc subunit)|interpro:IPR036753|reactome:R-SCE-2029482|reactome:R-SCE-5663213|reactome:R-SCE-8856828	-	crc64:4C9E8952B477A1B9	crc64:456EABC2B9CC4860	figure legend:5|comment:Complexes forms in strains in which Arc40 has been deleted, but Arp2 is less strongly associated within it.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/05/02	2014/10/16	rogid:baSDcw/PZH3Z8YHhIcYqtlNO3mw559292	rogid:Fj4cwULcw1TK5uS1lJczcNc5gns559292	intact-crc:4DF03464A0EFA701|rigid:McNiSPV2vmz7f8C16k3ik/XCOCY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32381	uniprotkb:P40518	intact:EBI-2927|uniprotkb:D6VRW3|ensemblfungi:YDL029W	intact:EBI-2750|uniprotkb:D6VVM2|ensemblfungi:YIL062C	psi-mi:arp2_yeast(display_long)|uniprotkb:ACT2(gene name synonym)|uniprotkb:YDL029W(locus name)|uniprotkb:D2778(orf name)|uniprotkb:ARP2(gene name)|psi-mi:ARP2(display_short)|uniprotkb:Actin-like protein ARP2(gene name synonym)	psi-mi:arpc5_yeast(display_long)|uniprotkb:ARC15(gene name)|psi-mi:ARC15(display_short)|uniprotkb:Arp2/3 complex 16 kDa subunit(gene name synonym)|uniprotkb:YIL062C(locus name)	psi-mi:"MI:0071"(molecular sieving)	Pan et al. (2004)	pubmed:15485833	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1249890	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010255.1|sgd:S000002187|dip:DIP-2217N|mint:P32381|ensemblfungi:YDL029W(gene)|ensemblfungi:YDL029W_mRNA(transcript)|go:"GO:0000001"(mitochondrion inheritance)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030476"(ascospore wall assembly)|go:"GO:0030479"(actin cortical patch)|go:"GO:0032258"(cytoplasm to vacuole transport by the Cvt pathway)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0044396"(actin cortical patch organization)|go:"GO:0051654"(establishment of mitochondrion localization)|interpro:IPR004000(Actin/actin-like)|interpro:IPR020902|interpro:IPR043129|reactome:R-SCE-2029482|reactome:R-SCE-5663213|reactome:R-SCE-6798695|reactome:R-SCE-8856828	refseq:NP_012202.1|sgd:S000001324|dip:DIP-2101N|mint:P40518|ensemblfungi:YIL062C(gene)|ensemblfungi:YIL062C_mRNA(transcript)|go:"GO:0000001"(mitochondrion inheritance)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0030479"(actin cortical patch)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0044396"(actin cortical patch organization)|go:"GO:0051015"(actin filament binding)|interpro:IPR006789("ARP2/3 complex 16 kDa subunit (p16-Arc)")|interpro:IPR036743|reactome:R-SCE-2029482|reactome:R-SCE-5663213|reactome:R-SCE-6798695|reactome:R-SCE-8856828	-	crc64:4C9E8952B477A1B9	crc64:10E4DAF0F0801B02	figure legend:5|comment:Complexes forms in strains in which Arc40 has been deleted, but Arp2 is less strongly associated within it.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/05/02	2014/10/16	rogid:baSDcw/PZH3Z8YHhIcYqtlNO3mw559292	rogid:iQ0mLisINMjXPulrRyDmrLcdpzU559292	intact-crc:4DF03464A0EFA701|rigid:McNiSPV2vmz7f8C16k3ik/XCOCY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47117	uniprotkb:O00401	intact:EBI-2933|uniprotkb:D6VWN6|ensemblfungi:YJR065C	intact:EBI-957615|ensembl:ENSP00000223023|uniprotkb:Q7Z746|uniprotkb:A1JUI9	psi-mi:arp3_yeast(display_long)|uniprotkb:ARP3(gene name)|psi-mi:ARP3(display_short)|uniprotkb:ACT4(gene name synonym)|uniprotkb:YJR065C(locus name)|uniprotkb:J1760(orf name)|uniprotkb:Actin-like protein ARP3(gene name synonym)	psi-mi:wasl_human(display_long)|uniprotkb:WASL(gene name)|psi-mi:WASL(display_short)	psi-mi:"MI:0096"(pull down)	Pan et al. (2004)	pubmed:15485833	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1249836	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003826|refseq:NP_012599.3|dip:DIP-2649N|mint:P47117|ensemblfungi:YJR065C(gene)|ensemblfungi:YJR065C_mRNA(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0030479"(actin cortical patch)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0044396"(actin cortical patch organization)|interpro:IPR004000(Actin/actin-like)|interpro:IPR015623(Actin-related protein 3)|interpro:IPR020902|interpro:IPR043129|reactome:R-SCE-2029482|reactome:R-SCE-5663213|reactome:R-SCE-8856828	go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0009617"(response to bacterium)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030478"(actin cap)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|rcsb pdb:2FF3|rcsb pdb:2LNH|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|rcsb pdb:2VCP|rcsb pdb:4CC2|rcsb pdb:4CC7|reactome:R-HSA-2029482|reactome:R-HSA-203641|reactome:R-HSA-373753|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013424|reactome:R-HSA-9664422|ensembl:ENSG00000106299(gene)|ensembl:ENST00000223023(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0051301"(cell division)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936|mint:O00401|go:"GO:0005634"(nucleus)|refseq:NP_003932.3|dip:DIP-29042N	-	crc64:5BBD87E83F476E9F	-	figure legend:3A,6A|comment:WASP1 incubated with entire isolated Arp2/3 complex but only Arp3 identified by western blot. Isolation of the complex from Arc40 deficient cells indicated that loss of Arc40 strongly reduced the affinity of VCA with the Arp2/3 complex. The use of Arp2 deficient cells suggested that lack of Arp2 had only a slight effect on the interaction between Arp2/3 complex with VCA and that that ARPC1/Arc40 mediates a major interaction between the Arp2/3 complex and VCA.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/05/02	2015/11/16	rogid:zQX5F88/vot1WLMuLvVXxFh8aBk559292	rogid:PinEPh47IRuCgiaJJZqStRhIAGQ9606	intact-crc:74C36B6B7C82B699|rigid:9v9WHkIPre6dTheskgRpGO1+C6I	false	-	mutation decreasing interaction:503-503|glutathione s tranferase tag:?-?|sufficient binding region:392..392-505..505	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00401	uniprotkb:P32381	intact:EBI-957615|ensembl:ENSP00000223023|uniprotkb:Q7Z746|uniprotkb:A1JUI9	intact:EBI-2927|uniprotkb:D6VRW3|ensemblfungi:YDL029W	psi-mi:wasl_human(display_long)|uniprotkb:WASL(gene name)|psi-mi:WASL(display_short)	psi-mi:arp2_yeast(display_long)|uniprotkb:ACT2(gene name synonym)|uniprotkb:YDL029W(locus name)|uniprotkb:D2778(orf name)|uniprotkb:ARP2(gene name)|psi-mi:ARP2(display_short)|uniprotkb:Actin-like protein ARP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pan et al. (2004)	pubmed:15485833	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1249917	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0009617"(response to bacterium)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030478"(actin cap)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|rcsb pdb:2FF3|rcsb pdb:2LNH|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|rcsb pdb:2VCP|rcsb pdb:4CC2|rcsb pdb:4CC7|reactome:R-HSA-2029482|reactome:R-HSA-203641|reactome:R-HSA-373753|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013424|reactome:R-HSA-9664422|ensembl:ENSG00000106299(gene)|ensembl:ENST00000223023(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0051301"(cell division)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936|mint:O00401|go:"GO:0005634"(nucleus)|refseq:NP_003932.3|dip:DIP-29042N	refseq:NP_010255.1|sgd:S000002187|dip:DIP-2217N|mint:P32381|ensemblfungi:YDL029W(gene)|ensemblfungi:YDL029W_mRNA(transcript)|go:"GO:0000001"(mitochondrion inheritance)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030476"(ascospore wall assembly)|go:"GO:0030479"(actin cortical patch)|go:"GO:0032258"(cytoplasm to vacuole transport by the Cvt pathway)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0044396"(actin cortical patch organization)|go:"GO:0051654"(establishment of mitochondrion localization)|interpro:IPR004000(Actin/actin-like)|interpro:IPR020902|interpro:IPR043129|reactome:R-SCE-2029482|reactome:R-SCE-5663213|reactome:R-SCE-6798695|reactome:R-SCE-8856828	-	-	crc64:4C9E8952B477A1B9	figure legend:6B, 6C|comment:WASP1 incubated with entire isolated Arp2/3 complex but only Arp2 identified by western blot. Isolation of the complex from Arc40 deficient cells indicated that loss of Arc40 strongly reduced the affinity of VCA with the Arp2/3 complex. The use of Arp2 deficient cells suggested that lack of Arp2 and Arp3 had only a slight effect on the interaction between Arp2/3 complex with VCA and that that ARPC1/Arc40 mediates a major interaction between the Arp2/3 complex and VCA.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/05/02	2015/11/16	rogid:PinEPh47IRuCgiaJJZqStRhIAGQ9606	rogid:baSDcw/PZH3Z8YHhIcYqtlNO3mw559292	intact-crc:3E0A0A338315A795|rigid:ixf9UmDmFkMxlKGaSOAQAybb+PM	false	mutation decreasing interaction:503-503|glutathione s tranferase tag:?-?|sufficient binding region:392..392-505..505	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)