#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32485	uniprotkb:P38634	intact:EBI-8437|uniprotkb:Q06232|uniprotkb:Q12294|uniprotkb:D6VYB1|ensemblfungi:YLR113W	intact:EBI-17127|ensemblfungi:YLR079W|uniprotkb:D6VY79	psi-mi:hog1_yeast(display_long)|uniprotkb:HOG1(gene name)|psi-mi:HOG1(display_short)|uniprotkb:SSK3(gene name synonym)|uniprotkb:YLR113W(locus name)|uniprotkb:L2931(orf name)|uniprotkb:L9354.2(orf name)|uniprotkb:High osmolarity glycerol response protein 1(gene name synonym)	psi-mi:sic1_yeast(display_long)|uniprotkb:SIC1(gene name)|psi-mi:SIC1(display_short)|uniprotkb:SDB25(gene name synonym)|uniprotkb:YLR079W(locus name)|uniprotkb:L9449.8(orf name)|uniprotkb:CDK inhibitor p40(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Escote et al. (2004)	pubmed:15448699	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1395739	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013214.1|sgd:S000004103|dip:DIP-1558N|mint:P32485|ensemblfungi:YLR113W_mRNA(transcript)|go:"GO:0001100"(negative regulation of exit from mitosis)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038783|reactome:R-SCE-168638|reactome:R-SCE-193648|reactome:R-SCE-198753|reactome:R-SCE-2559580|reactome:R-SCE-2871796|reactome:R-SCE-418592|reactome:R-SCE-432142|reactome:R-SCE-450321|reactome:R-SCE-450341|reactome:R-SCE-525793|reactome:R-SCE-6798695|reactome:R-SCE-9007892|ensemblfungi:YLR113W(gene)	ensemblfungi:YLR079W(gene)|ensemblfungi:YLR079W_mRNA(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016242"(negative regulation of macroautophagy)|rcsb pdb:3V7D|rcsb pdb:6G86|refseq:NP_013180.1|sgd:S000004069|dip:DIP-6817N|mint:P38634	-	crc64:D95A20242587CE06	crc64:7913636340678F78	figure legend:3a	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/13	2014/10/16	rogid:Re8xLAJEvP2Fjr0lOGtLB6ANybM559292	rogid:qU8ivBCZHvG4VmXDxv52yc08Hwc559292	intact-crc:7867317E280EA379|rigid:SsQzxwx8B3bQ0yMPdZtmjOO6+aA	false	-	binding-associated region:1-207	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38128	uniprotkb:P32485	intact:EBI-17469|uniprotkb:D6VQH6|ensemblfungi:YBR182C	intact:EBI-8437|uniprotkb:Q06232|uniprotkb:Q12294|uniprotkb:D6VYB1|ensemblfungi:YLR113W	psi-mi:smp1_yeast(display_long)|uniprotkb:YBR1245(orf name)|uniprotkb:YBR182C(locus name)|uniprotkb:SMP1(gene name)|psi-mi:SMP1(display_short)	psi-mi:hog1_yeast(display_long)|uniprotkb:HOG1(gene name)|psi-mi:HOG1(display_short)|uniprotkb:SSK3(gene name synonym)|uniprotkb:YLR113W(locus name)|uniprotkb:L2931(orf name)|uniprotkb:L9354.2(orf name)|uniprotkb:High osmolarity glycerol response protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Escote et al. (2004)	pubmed:15448699	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1395753	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009741.3|sgd:S000000386|interpro:IPR002100(Transcription factor, MADS-box)|ensemblfungi:YBR182C(gene)|ensemblfungi:YBR182C_mRNA(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|reactome:R-SCE-525793|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR033896|interpro:IPR036879	refseq:NP_013214.1|sgd:S000004103|dip:DIP-1558N|mint:P32485|ensemblfungi:YLR113W_mRNA(transcript)|go:"GO:0001100"(negative regulation of exit from mitosis)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038783|reactome:R-SCE-168638|reactome:R-SCE-193648|reactome:R-SCE-198753|reactome:R-SCE-2559580|reactome:R-SCE-2871796|reactome:R-SCE-418592|reactome:R-SCE-432142|reactome:R-SCE-450321|reactome:R-SCE-450341|reactome:R-SCE-525793|reactome:R-SCE-6798695|reactome:R-SCE-9007892|ensemblfungi:YLR113W(gene)	-	-	crc64:D95A20242587CE06	figure legend:3a	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/13	2014/10/16	rogid:+iBP5NzZkrXnslYfo1RDMrlTAIQ559292	rogid:Re8xLAJEvP2Fjr0lOGtLB6ANybM559292	intact-crc:A9B2C922A9F52F0C|rigid:/7kCU/oyezqRLaYNW7kNMleVvro	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38634	uniprotkb:P07834	intact:EBI-17127|ensemblfungi:YLR079W|uniprotkb:D6VY79	intact:EBI-4434|ensemblfungi:YFL009W|uniprotkb:D6VTM1	psi-mi:sic1_yeast(display_long)|uniprotkb:SIC1(gene name)|psi-mi:SIC1(display_short)|uniprotkb:SDB25(gene name synonym)|uniprotkb:YLR079W(locus name)|uniprotkb:L9449.8(orf name)|uniprotkb:CDK inhibitor p40(gene name synonym)	psi-mi:cdc4_yeast(display_long)|uniprotkb:CDC4(gene name)|psi-mi:CDC4(display_short)|uniprotkb:YFL009W(locus name)|uniprotkb:F-box protein CDC4(gene name synonym)|uniprotkb:E3 ubiquitin ligase complex SCF subunit CDC4(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Escote et al. (2004)	pubmed:15448699	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1396099	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YLR079W(gene)|ensemblfungi:YLR079W_mRNA(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016242"(negative regulation of macroautophagy)|rcsb pdb:3V7D|rcsb pdb:6G86|refseq:NP_013180.1|sgd:S000004069|dip:DIP-6817N|mint:P38634	reactome:R-SCE-174113|reactome:R-SCE-8951664|reactome:R-SCE-983168|ensemblfungi:YFL009W(gene)|ensemblfungi:YFL009W_mRNA(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000472"("endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000480"("endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030686"(90S preribosome)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0043130"(ubiquitin binding)|refseq:NP_116585.1|sgd:S000001885|dip:DIP-1625N|go:"GO:0043224"(nuclear SCF ubiquitin ligase complex)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR031740|interpro:IPR036047|interpro:IPR036322|rcsb pdb:1NEX|rcsb pdb:2P63|rcsb pdb:3MKS|rcsb pdb:3V7D	-	crc64:7913636340678F78	crc64:0348F2F8FA78F3BC	figure legend:4f	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/13	2014/10/16	rogid:qU8ivBCZHvG4VmXDxv52yc08Hwc559292	rogid:KUKB7HDw6k4t7Gb1pDGW8P5J1kw559292	intact-crc:476603F7CAE97DC9|rigid:x4PVsGEWvI22mW8knb/BRe0jvoE	false	mutation decreasing interaction:173-173	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32485	uniprotkb:P38634	intact:EBI-8437|uniprotkb:Q06232|uniprotkb:Q12294|uniprotkb:D6VYB1|ensemblfungi:YLR113W	intact:EBI-17127|ensemblfungi:YLR079W|uniprotkb:D6VY79	psi-mi:hog1_yeast(display_long)|uniprotkb:HOG1(gene name)|psi-mi:HOG1(display_short)|uniprotkb:SSK3(gene name synonym)|uniprotkb:YLR113W(locus name)|uniprotkb:L2931(orf name)|uniprotkb:L9354.2(orf name)|uniprotkb:High osmolarity glycerol response protein 1(gene name synonym)	psi-mi:sic1_yeast(display_long)|uniprotkb:SIC1(gene name)|psi-mi:SIC1(display_short)|uniprotkb:SDB25(gene name synonym)|uniprotkb:YLR079W(locus name)|uniprotkb:L9449.8(orf name)|uniprotkb:CDK inhibitor p40(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Escote et al. (2004)	pubmed:15448699	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1395796	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013214.1|sgd:S000004103|dip:DIP-1558N|mint:P32485|ensemblfungi:YLR113W_mRNA(transcript)|go:"GO:0001100"(negative regulation of exit from mitosis)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038783|reactome:R-SCE-168638|reactome:R-SCE-193648|reactome:R-SCE-198753|reactome:R-SCE-2559580|reactome:R-SCE-2871796|reactome:R-SCE-418592|reactome:R-SCE-432142|reactome:R-SCE-450321|reactome:R-SCE-450341|reactome:R-SCE-525793|reactome:R-SCE-6798695|reactome:R-SCE-9007892|ensemblfungi:YLR113W(gene)	ensemblfungi:YLR079W(gene)|ensemblfungi:YLR079W_mRNA(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016242"(negative regulation of macroautophagy)|rcsb pdb:3V7D|rcsb pdb:6G86|refseq:NP_013180.1|sgd:S000004069|dip:DIP-6817N|mint:P38634	-	crc64:D95A20242587CE06	crc64:7913636340678F78	figure legend:3b	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/13	2014/10/16	rogid:Re8xLAJEvP2Fjr0lOGtLB6ANybM559292	rogid:qU8ivBCZHvG4VmXDxv52yc08Hwc559292	intact-crc:2ACF700CCAA1857F|rigid:SsQzxwx8B3bQ0yMPdZtmjOO6+aA	false	glutathione s tranferase tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P32485	uniprotkb:P38634	intact:EBI-8437|uniprotkb:Q06232|uniprotkb:Q12294|uniprotkb:D6VYB1|ensemblfungi:YLR113W	intact:EBI-17127|ensemblfungi:YLR079W|uniprotkb:D6VY79	psi-mi:hog1_yeast(display_long)|uniprotkb:HOG1(gene name)|psi-mi:HOG1(display_short)|uniprotkb:SSK3(gene name synonym)|uniprotkb:YLR113W(locus name)|uniprotkb:L2931(orf name)|uniprotkb:L9354.2(orf name)|uniprotkb:High osmolarity glycerol response protein 1(gene name synonym)	psi-mi:sic1_yeast(display_long)|uniprotkb:SIC1(gene name)|psi-mi:SIC1(display_short)|uniprotkb:SDB25(gene name synonym)|uniprotkb:YLR079W(locus name)|uniprotkb:L9449.8(orf name)|uniprotkb:CDK inhibitor p40(gene name synonym)	psi-mi:"MI:0096"(pull down)	Escote et al. (2004)	pubmed:15448699	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1395824	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013214.1|sgd:S000004103|dip:DIP-1558N|mint:P32485|ensemblfungi:YLR113W_mRNA(transcript)|go:"GO:0001100"(negative regulation of exit from mitosis)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038783|reactome:R-SCE-168638|reactome:R-SCE-193648|reactome:R-SCE-198753|reactome:R-SCE-2559580|reactome:R-SCE-2871796|reactome:R-SCE-418592|reactome:R-SCE-432142|reactome:R-SCE-450321|reactome:R-SCE-450341|reactome:R-SCE-525793|reactome:R-SCE-6798695|reactome:R-SCE-9007892|ensemblfungi:YLR113W(gene)	ensemblfungi:YLR079W(gene)|ensemblfungi:YLR079W_mRNA(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016242"(negative regulation of macroautophagy)|rcsb pdb:3V7D|rcsb pdb:6G86|refseq:NP_013180.1|sgd:S000004069|dip:DIP-6817N|mint:P38634	-	crc64:D95A20242587CE06	crc64:7913636340678F78	figure legend:3c	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/13	2014/10/16	rogid:Re8xLAJEvP2Fjr0lOGtLB6ANybM559292	rogid:qU8ivBCZHvG4VmXDxv52yc08Hwc559292	intact-crc:A22FD4214E3FAF9A|rigid:SsQzxwx8B3bQ0yMPdZtmjOO6+aA	false	ha tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P32485	uniprotkb:P38634	intact:EBI-8437|uniprotkb:Q06232|uniprotkb:Q12294|uniprotkb:D6VYB1|ensemblfungi:YLR113W	intact:EBI-17127|ensemblfungi:YLR079W|uniprotkb:D6VY79	psi-mi:hog1_yeast(display_long)|uniprotkb:HOG1(gene name)|psi-mi:HOG1(display_short)|uniprotkb:SSK3(gene name synonym)|uniprotkb:YLR113W(locus name)|uniprotkb:L2931(orf name)|uniprotkb:L9354.2(orf name)|uniprotkb:High osmolarity glycerol response protein 1(gene name synonym)	psi-mi:sic1_yeast(display_long)|uniprotkb:SIC1(gene name)|psi-mi:SIC1(display_short)|uniprotkb:SDB25(gene name synonym)|uniprotkb:YLR079W(locus name)|uniprotkb:L9449.8(orf name)|uniprotkb:CDK inhibitor p40(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Escote et al. (2004)	pubmed:15448699	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1395908	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013214.1|sgd:S000004103|dip:DIP-1558N|mint:P32485|ensemblfungi:YLR113W_mRNA(transcript)|go:"GO:0001100"(negative regulation of exit from mitosis)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038783|reactome:R-SCE-168638|reactome:R-SCE-193648|reactome:R-SCE-198753|reactome:R-SCE-2559580|reactome:R-SCE-2871796|reactome:R-SCE-418592|reactome:R-SCE-432142|reactome:R-SCE-450321|reactome:R-SCE-450341|reactome:R-SCE-525793|reactome:R-SCE-6798695|reactome:R-SCE-9007892|ensemblfungi:YLR113W(gene)	ensemblfungi:YLR079W(gene)|ensemblfungi:YLR079W_mRNA(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016242"(negative regulation of macroautophagy)|rcsb pdb:3V7D|rcsb pdb:6G86|refseq:NP_013180.1|sgd:S000004069|dip:DIP-6817N|mint:P38634	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	crc64:D95A20242587CE06	crc64:7913636340678F78	resulting-ptm:SIC1 is phosphorylated on Tyr173 as determined by autoradiography and use of SIC1 mutant constructs.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/13	2014/10/16	rogid:Re8xLAJEvP2Fjr0lOGtLB6ANybM559292	rogid:qU8ivBCZHvG4VmXDxv52yc08Hwc559292	intact-crc:FB1CD63F3A97BD2A|rigid:SsQzxwx8B3bQ0yMPdZtmjOO6+aA	false	glutathione s tranferase tag:?-?	mutation disrupting interaction:173-173	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)