#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q00721 intact:EBI-1263954 intact:EBI-1263962 - psi-mi:nsp3_rots4(display_long)|uniprotkb:Non-structural RNA-binding protein 34(gene name synonym)|uniprotkb:NCVP4(gene name synonym) psi-mi:z3h7b_cerae_protein(display_short)|psi-mi:EBI-1263954(display_long) psi-mi:"MI:0018"(two hybrid) Vitour et al. (2004) pubmed:15047801 taxid:36436(rots4)|taxid:36436("Rotavirus A (strain SA11-4F G3-P6[1]-Ix-Rx-Cx-Mx-Ax-Nx-Tx-Ex-Hx) (RV-A)") taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1263957 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002873(Non-structural protein NSP3, Rotavirus)|interpro:IPR042519|interpro:IPR036082|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0030430"(host cell cytoplasm) - - - no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Similar to Q9UGR2 - taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2007/06/13 2014/10/16 rogid:8+WjY8janozUg7W4RSGd2hiy/yI36436 - intact-crc:F1D4E52E2E65E0AD false sufficient binding region:90-315 - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) intact:EBI-1263971 uniprotkb:Q00721 - intact:EBI-1263962 psi-mi:if4g1_cerae_protein(display_short)|psi-mi:EBI-1263971(display_long) psi-mi:nsp3_rots4(display_long)|uniprotkb:Non-structural RNA-binding protein 34(gene name synonym)|uniprotkb:NCVP4(gene name synonym) psi-mi:"MI:0018"(two hybrid) Vitour et al. (2004) pubmed:15047801 taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) taxid:36436(rots4)|taxid:36436("Rotavirus A (strain SA11-4F G3-P6[1]-Ix-Rx-Cx-Mx-Ax-Nx-Tx-Ex-Hx) (RV-A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1263974 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - interpro:IPR002873(Non-structural protein NSP3, Rotavirus)|interpro:IPR042519|interpro:IPR036082|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0030430"(host cell cytoplasm) - no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Similar to Q04637 - - taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2007/06/13 2014/10/16 - rogid:8+WjY8janozUg7W4RSGd2hiy/yI36436 intact-crc:42ECC976D0C8D5B3 false - sufficient binding region:90-315 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9UGR2 uniprotkb:Q00721 intact:EBI-948845|ensembl:ENSP00000345793|uniprotkb:Q5TFX9|uniprotkb:Q8TBT9|uniprotkb:Q9H8B6|uniprotkb:Q9UGQ9|uniprotkb:Q9UGR0|uniprotkb:Q9UGR1|uniprotkb:Q9UK03|uniprotkb:Q9UPW9|uniprotkb:A7YY88|uniprotkb:B2RCA4 intact:EBI-1263962 psi-mi:z3h7b_human(display_long)|uniprotkb:Rotavirus 'X'-associated non-structural protein(gene name synonym)|uniprotkb:ZC3H7B(gene name)|psi-mi:ZC3H7B(display_short)|uniprotkb:KIAA1031(gene name synonym) psi-mi:nsp3_rots4(display_long)|uniprotkb:Non-structural RNA-binding protein 34(gene name synonym)|uniprotkb:NCVP4(gene name synonym) psi-mi:"MI:0018"(two hybrid) Vitour et al. (2004) pubmed:15047801 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:36436(rots4)|taxid:36436("Rotavirus A (strain SA11-4F G3-P6[1]-Ix-Rx-Cx-Mx-Ax-Nx-Tx-Ex-Hx) (RV-A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1263991 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000100403(gene)|ensembl:ENST00000352645(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036236|interpro:IPR036855|interpro:IPR039691|refseq:NP_060060.3 interpro:IPR002873(Non-structural protein NSP3, Rotavirus)|interpro:IPR042519|interpro:IPR036082|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0030430"(host cell cytoplasm) - - - caution:Sequence length of Q00721 is 315, not 313 as stated in the paper, so deletion mutants have been reannoted to sequence as given.|figure legend:2A taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2007/06/13 2019/01/23 rogid:OoA5aL/8pJANSn6oKUqJsMWbAgY9606 rogid:8+WjY8janozUg7W4RSGd2hiy/yI36436 intact-crc:6EC949F2020A06DE|rigid:wLKFKVUUR//+jke2a2qAFk/85V4 false sufficient binding region:228-325 sufficient binding region:88-315 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UGR2 uniprotkb:Q00721 intact:EBI-948845|ensembl:ENSP00000345793|uniprotkb:Q5TFX9|uniprotkb:Q8TBT9|uniprotkb:Q9H8B6|uniprotkb:Q9UGQ9|uniprotkb:Q9UGR0|uniprotkb:Q9UGR1|uniprotkb:Q9UK03|uniprotkb:Q9UPW9|uniprotkb:A7YY88|uniprotkb:B2RCA4 intact:EBI-1263962 psi-mi:z3h7b_human(display_long)|uniprotkb:Rotavirus 'X'-associated non-structural protein(gene name synonym)|uniprotkb:ZC3H7B(gene name)|psi-mi:ZC3H7B(display_short)|uniprotkb:KIAA1031(gene name synonym) psi-mi:nsp3_rots4(display_long)|uniprotkb:Non-structural RNA-binding protein 34(gene name synonym)|uniprotkb:NCVP4(gene name synonym) psi-mi:"MI:0018"(two hybrid) Vitour et al. (2004) pubmed:15047801 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:36436(rots4)|taxid:36436("Rotavirus A (strain SA11-4F G3-P6[1]-Ix-Rx-Cx-Mx-Ax-Nx-Tx-Ex-Hx) (RV-A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1264004 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000100403(gene)|ensembl:ENST00000352645(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036236|interpro:IPR036855|interpro:IPR039691|refseq:NP_060060.3 interpro:IPR002873(Non-structural protein NSP3, Rotavirus)|interpro:IPR042519|interpro:IPR036082|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0030430"(host cell cytoplasm) - - - caution:Sequence length of Q00721 is 315, not 313 as stated in the paper, so deletion mutants have been reannoted to sequence as given.|figure legend:2A taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2007/06/13 2019/01/23 rogid:OoA5aL/8pJANSn6oKUqJsMWbAgY9606 rogid:8+WjY8janozUg7W4RSGd2hiy/yI36436 intact-crc:C9C48DBD79E2EAD1|rigid:wLKFKVUUR//+jke2a2qAFk/85V4 false sufficient binding region:1-387 sufficient binding region:165-242 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q00721 uniprotkb:Q00721 intact:EBI-1263962 intact:EBI-1263962 psi-mi:nsp3_rots4(display_long)|uniprotkb:Non-structural RNA-binding protein 34(gene name synonym)|uniprotkb:NCVP4(gene name synonym) psi-mi:nsp3_rots4(display_long)|uniprotkb:Non-structural RNA-binding protein 34(gene name synonym)|uniprotkb:NCVP4(gene name synonym) psi-mi:"MI:0018"(two hybrid) Vitour et al. (2004) pubmed:15047801 taxid:36436(rots4)|taxid:36436("Rotavirus A (strain SA11-4F G3-P6[1]-Ix-Rx-Cx-Mx-Ax-Nx-Tx-Ex-Hx) (RV-A)") taxid:36436(rots4)|taxid:36436("Rotavirus A (strain SA11-4F G3-P6[1]-Ix-Rx-Cx-Mx-Ax-Nx-Tx-Ex-Hx) (RV-A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1264085 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002873(Non-structural protein NSP3, Rotavirus)|interpro:IPR042519|interpro:IPR036082|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0030430"(host cell cytoplasm) interpro:IPR002873(Non-structural protein NSP3, Rotavirus)|interpro:IPR042519|interpro:IPR036082|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0030430"(host cell cytoplasm) - - - figure legend:5 taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2007/06/13 2014/10/16 rogid:8+WjY8janozUg7W4RSGd2hiy/yI36436 rogid:8+WjY8janozUg7W4RSGd2hiy/yI36436 intact-crc:5A44692834019571|rigid:MFvvuezkb35I5BPSnP6rjNsg3Jo false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q00721 uniprotkb:Q9UGR2 intact:EBI-1263962 intact:EBI-948845|ensembl:ENSP00000345793|uniprotkb:Q5TFX9|uniprotkb:Q8TBT9|uniprotkb:Q9H8B6|uniprotkb:Q9UGQ9|uniprotkb:Q9UGR0|uniprotkb:Q9UGR1|uniprotkb:Q9UK03|uniprotkb:Q9UPW9|uniprotkb:A7YY88|uniprotkb:B2RCA4 psi-mi:nsp3_rots4(display_long)|uniprotkb:Non-structural RNA-binding protein 34(gene name synonym)|uniprotkb:NCVP4(gene name synonym) psi-mi:z3h7b_human(display_long)|uniprotkb:Rotavirus 'X'-associated non-structural protein(gene name synonym)|uniprotkb:ZC3H7B(gene name)|psi-mi:ZC3H7B(display_short)|uniprotkb:KIAA1031(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Vitour et al. (2004) pubmed:15047801 taxid:36436(rots4)|taxid:36436("Rotavirus A (strain SA11-4F G3-P6[1]-Ix-Rx-Cx-Mx-Ax-Nx-Tx-Ex-Hx) (RV-A)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1264021 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002873(Non-structural protein NSP3, Rotavirus)|interpro:IPR042519|interpro:IPR036082|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0030430"(host cell cytoplasm) ensembl:ENSG00000100403(gene)|ensembl:ENST00000352645(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036236|interpro:IPR036855|interpro:IPR039691|refseq:NP_060060.3 - - - figure legend:3A taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2007/06/13 2019/01/23 rogid:8+WjY8janozUg7W4RSGd2hiy/yI36436 rogid:OoA5aL/8pJANSn6oKUqJsMWbAgY9606 intact-crc:10340FF144A9E747|rigid:wLKFKVUUR//+jke2a2qAFk/85V4 false - sufficient binding region:1-387|flag tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UGR2 uniprotkb:Q00721 intact:EBI-948845|ensembl:ENSP00000345793|uniprotkb:Q5TFX9|uniprotkb:Q8TBT9|uniprotkb:Q9H8B6|uniprotkb:Q9UGQ9|uniprotkb:Q9UGR0|uniprotkb:Q9UGR1|uniprotkb:Q9UK03|uniprotkb:Q9UPW9|uniprotkb:A7YY88|uniprotkb:B2RCA4 intact:EBI-1263962 psi-mi:z3h7b_human(display_long)|uniprotkb:Rotavirus 'X'-associated non-structural protein(gene name synonym)|uniprotkb:ZC3H7B(gene name)|psi-mi:ZC3H7B(display_short)|uniprotkb:KIAA1031(gene name synonym) psi-mi:nsp3_rots4(display_long)|uniprotkb:Non-structural RNA-binding protein 34(gene name synonym)|uniprotkb:NCVP4(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Vitour et al. (2004) pubmed:15047801 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:36436(rots4)|taxid:36436("Rotavirus A (strain SA11-4F G3-P6[1]-Ix-Rx-Cx-Mx-Ax-Nx-Tx-Ex-Hx) (RV-A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1264034 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000100403(gene)|ensembl:ENST00000352645(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036236|interpro:IPR036855|interpro:IPR039691|refseq:NP_060060.3 interpro:IPR002873(Non-structural protein NSP3, Rotavirus)|interpro:IPR042519|interpro:IPR036082|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0030430"(host cell cytoplasm) - - - figure legend:3B taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2007/06/13 2019/01/23 rogid:OoA5aL/8pJANSn6oKUqJsMWbAgY9606 rogid:8+WjY8janozUg7W4RSGd2hiy/yI36436 intact-crc:8956079CB16B1B3B|rigid:wLKFKVUUR//+jke2a2qAFk/85V4 false sufficient binding region:1-387|flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UGR2 uniprotkb:Q00721 intact:EBI-948845|ensembl:ENSP00000345793|uniprotkb:Q5TFX9|uniprotkb:Q8TBT9|uniprotkb:Q9H8B6|uniprotkb:Q9UGQ9|uniprotkb:Q9UGR0|uniprotkb:Q9UGR1|uniprotkb:Q9UK03|uniprotkb:Q9UPW9|uniprotkb:A7YY88|uniprotkb:B2RCA4 intact:EBI-1263962 psi-mi:z3h7b_human(display_long)|uniprotkb:Rotavirus 'X'-associated non-structural protein(gene name synonym)|uniprotkb:ZC3H7B(gene name)|psi-mi:ZC3H7B(display_short)|uniprotkb:KIAA1031(gene name synonym) psi-mi:nsp3_rots4(display_long)|uniprotkb:Non-structural RNA-binding protein 34(gene name synonym)|uniprotkb:NCVP4(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Vitour et al. (2004) pubmed:15047801 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:36436(rots4)|taxid:36436("Rotavirus A (strain SA11-4F G3-P6[1]-Ix-Rx-Cx-Mx-Ax-Nx-Tx-Ex-Hx) (RV-A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1264053 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000100403(gene)|ensembl:ENST00000352645(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036236|interpro:IPR036855|interpro:IPR039691|refseq:NP_060060.3 interpro:IPR002873(Non-structural protein NSP3, Rotavirus)|interpro:IPR042519|interpro:IPR036082|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0030430"(host cell cytoplasm) - - - figure legend:3C|caution:Q9UGR2 has a length of 993 amino acids, not 977 as given in the paper taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2007/06/13 2019/01/23 rogid:OoA5aL/8pJANSn6oKUqJsMWbAgY9606 rogid:8+WjY8janozUg7W4RSGd2hiy/yI36436 intact-crc:17A2CFCFD6997BA5|rigid:wLKFKVUUR//+jke2a2qAFk/85V4 false t7 tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UGR2 uniprotkb:Q00721 intact:EBI-948845|ensembl:ENSP00000345793|uniprotkb:Q5TFX9|uniprotkb:Q8TBT9|uniprotkb:Q9H8B6|uniprotkb:Q9UGQ9|uniprotkb:Q9UGR0|uniprotkb:Q9UGR1|uniprotkb:Q9UK03|uniprotkb:Q9UPW9|uniprotkb:A7YY88|uniprotkb:B2RCA4 intact:EBI-1263962 psi-mi:z3h7b_human(display_long)|uniprotkb:Rotavirus 'X'-associated non-structural protein(gene name synonym)|uniprotkb:ZC3H7B(gene name)|psi-mi:ZC3H7B(display_short)|uniprotkb:KIAA1031(gene name synonym) psi-mi:nsp3_rots4(display_long)|uniprotkb:Non-structural RNA-binding protein 34(gene name synonym)|uniprotkb:NCVP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Vitour et al. (2004) pubmed:15047801 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:36436(rots4)|taxid:36436("Rotavirus A (strain SA11-4F G3-P6[1]-Ix-Rx-Cx-Mx-Ax-Nx-Tx-Ex-Hx) (RV-A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1264069 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000100403(gene)|ensembl:ENST00000352645(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036236|interpro:IPR036855|interpro:IPR039691|refseq:NP_060060.3 interpro:IPR002873(Non-structural protein NSP3, Rotavirus)|interpro:IPR042519|interpro:IPR036082|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0030430"(host cell cytoplasm) - - - figure legend:4 and 7|caution:Q00721 has a length of 315 amino acids, not 313 as given in the paper taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2007/06/13 2019/01/23 rogid:OoA5aL/8pJANSn6oKUqJsMWbAgY9606 rogid:8+WjY8janozUg7W4RSGd2hiy/yI36436 intact-crc:EF15DDB8158BD6F9|rigid:wLKFKVUUR//+jke2a2qAFk/85V4 false t7 tag:n-n|necessary binding region:240-263|mutation decreasing interaction:252-254 sufficient binding region:150-315|green fluorescent protein tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q04637 uniprotkb:Q00721 intact:EBI-73711|uniprotkb:O43177|uniprotkb:O95066|uniprotkb:Q5HYG0|uniprotkb:Q6ZN21|uniprotkb:Q8N102|intact:EBI-11020102|uniprotkb:D3DNT4|uniprotkb:D3DNT5|uniprotkb:D3DNT2|uniprotkb:E9PFM1|uniprotkb:G5E9S1|intact:EBI-28974642|ensembl:ENSP00000316879 intact:EBI-1263962 psi-mi:if4g1_human(display_long)|uniprotkb:p220(gene name synonym)|uniprotkb:EIF4G1(gene name)|psi-mi:EIF4G1(display_short)|uniprotkb:EIF4G(gene name synonym)|uniprotkb:EIF4GI(gene name synonym)|uniprotkb:EIF4F(gene name synonym) psi-mi:nsp3_rots4(display_long)|uniprotkb:Non-structural RNA-binding protein 34(gene name synonym)|uniprotkb:NCVP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Vitour et al. (2004) pubmed:15047801 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:36436(rots4)|taxid:36436("Rotavirus A (strain SA11-4F G3-P6[1]-Ix-Rx-Cx-Mx-Ax-Nx-Tx-Ex-Hx) (RV-A)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1264191 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000342981|ensembl:ENSP00000343450|ensembl:ENSP00000316879|ensembl:ENST00000350481|ensembl:ENSP00000317600|ensembl:ENST00000352767|ensembl:ENSP00000338020|ensembl:ENST00000382330|ensembl:ENSP00000371767|ensembl:ENST00000392537|ensembl:ENSP00000376320|ensembl:ENST00000414031|ensembl:ENSP00000391935|ensembl:ENST00000424196|ensembl:ENSP00000416255|ensembl:ENST00000434061|ensembl:ENSP00000411826|refseq:NP_886553.3|refseq:NP_937884.1|refseq:NP_937885.1|refseq:NP_004944.3|dip:DIP-1161N|ensembl:ENSG00000114867(gene)|ensembl:ENST00000346169(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016020"(membrane)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032502"(developmental process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097009"(energy homeostasis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905537"(positive regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905612"(positive regulation of mRNA cap binding)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1905696"(regulation of polysome binding)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037584|mint:Q04637|rcsb pdb:1LJ2|rcsb pdb:1UG3|rcsb pdb:2W97|rcsb pdb:4AZA|rcsb pdb:4F02|rcsb pdb:5EHC|rcsb pdb:5EI3|rcsb pdb:5EIR|rcsb pdb:5T46|rcsb pdb:6ZMW|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-166208|reactome:R-HSA-429947|reactome:R-HSA-450408|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957 interpro:IPR002873(Non-structural protein NSP3, Rotavirus)|interpro:IPR042519|interpro:IPR036082|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0030430"(host cell cytoplasm) - - - figure legend:7|comment:Interaction only occurs in virally infected cells, even when the human proteins are highly over-expressed. taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2007/06/13 2019/01/23 rogid:0UfVxxWOLUvrvFfcteeTc2RrbhA9606 rogid:8+WjY8janozUg7W4RSGd2hiy/yI36436 intact-crc:549DE3C96728365E|rigid:MCxoeoDN0ED3AmczqKowZcph14A false - green fluorescent protein tag:150-315 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q04637 uniprotkb:Q9UGR2 intact:EBI-73711|uniprotkb:O43177|uniprotkb:O95066|uniprotkb:Q5HYG0|uniprotkb:Q6ZN21|uniprotkb:Q8N102|intact:EBI-11020102|uniprotkb:D3DNT4|uniprotkb:D3DNT5|uniprotkb:D3DNT2|uniprotkb:E9PFM1|uniprotkb:G5E9S1|intact:EBI-28974642|ensembl:ENSP00000316879 intact:EBI-948845|ensembl:ENSP00000345793|uniprotkb:Q5TFX9|uniprotkb:Q8TBT9|uniprotkb:Q9H8B6|uniprotkb:Q9UGQ9|uniprotkb:Q9UGR0|uniprotkb:Q9UGR1|uniprotkb:Q9UK03|uniprotkb:Q9UPW9|uniprotkb:A7YY88|uniprotkb:B2RCA4 psi-mi:if4g1_human(display_long)|uniprotkb:p220(gene name synonym)|uniprotkb:EIF4G1(gene name)|psi-mi:EIF4G1(display_short)|uniprotkb:EIF4G(gene name synonym)|uniprotkb:EIF4GI(gene name synonym)|uniprotkb:EIF4F(gene name synonym) psi-mi:z3h7b_human(display_long)|uniprotkb:Rotavirus 'X'-associated non-structural protein(gene name synonym)|uniprotkb:ZC3H7B(gene name)|psi-mi:ZC3H7B(display_short)|uniprotkb:KIAA1031(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Vitour et al. (2004) pubmed:15047801 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1264191 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000342981|ensembl:ENSP00000343450|ensembl:ENSP00000316879|ensembl:ENST00000350481|ensembl:ENSP00000317600|ensembl:ENST00000352767|ensembl:ENSP00000338020|ensembl:ENST00000382330|ensembl:ENSP00000371767|ensembl:ENST00000392537|ensembl:ENSP00000376320|ensembl:ENST00000414031|ensembl:ENSP00000391935|ensembl:ENST00000424196|ensembl:ENSP00000416255|ensembl:ENST00000434061|ensembl:ENSP00000411826|refseq:NP_886553.3|refseq:NP_937884.1|refseq:NP_937885.1|refseq:NP_004944.3|dip:DIP-1161N|ensembl:ENSG00000114867(gene)|ensembl:ENST00000346169(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016020"(membrane)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032502"(developmental process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097009"(energy homeostasis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905537"(positive regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905612"(positive regulation of mRNA cap binding)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1905696"(regulation of polysome binding)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037584|mint:Q04637|rcsb pdb:1LJ2|rcsb pdb:1UG3|rcsb pdb:2W97|rcsb pdb:4AZA|rcsb pdb:4F02|rcsb pdb:5EHC|rcsb pdb:5EI3|rcsb pdb:5EIR|rcsb pdb:5T46|rcsb pdb:6ZMW|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-166208|reactome:R-HSA-429947|reactome:R-HSA-450408|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957 ensembl:ENSG00000100403(gene)|ensembl:ENST00000352645(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036236|interpro:IPR036855|interpro:IPR039691|refseq:NP_060060.3 - - - figure legend:7|comment:Interaction only occurs in virally infected cells, even when the human proteins are highly over-expressed. taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2007/06/13 2019/01/23 rogid:0UfVxxWOLUvrvFfcteeTc2RrbhA9606 rogid:OoA5aL/8pJANSn6oKUqJsMWbAgY9606 intact-crc:549DE3C96728365E|rigid:MCxoeoDN0ED3AmczqKowZcph14A false - t7 tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q04637 uniprotkb:Q00721 intact:EBI-73711|uniprotkb:O43177|uniprotkb:O95066|uniprotkb:Q5HYG0|uniprotkb:Q6ZN21|uniprotkb:Q8N102|intact:EBI-11020102|uniprotkb:D3DNT4|uniprotkb:D3DNT5|uniprotkb:D3DNT2|uniprotkb:E9PFM1|uniprotkb:G5E9S1|intact:EBI-28974642|ensembl:ENSP00000316879 intact:EBI-1263962 psi-mi:if4g1_human(display_long)|uniprotkb:p220(gene name synonym)|uniprotkb:EIF4G1(gene name)|psi-mi:EIF4G1(display_short)|uniprotkb:EIF4G(gene name synonym)|uniprotkb:EIF4GI(gene name synonym)|uniprotkb:EIF4F(gene name synonym) psi-mi:nsp3_rots4(display_long)|uniprotkb:Non-structural RNA-binding protein 34(gene name synonym)|uniprotkb:NCVP4(gene name synonym) psi-mi:"MI:0588"(three hybrid) Vitour et al. (2004) pubmed:15047801 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:36436(rots4)|taxid:36436("Rotavirus A (strain SA11-4F G3-P6[1]-Ix-Rx-Cx-Mx-Ax-Nx-Tx-Ex-Hx) (RV-A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1264097 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000342981|ensembl:ENSP00000343450|ensembl:ENSP00000316879|ensembl:ENST00000350481|ensembl:ENSP00000317600|ensembl:ENST00000352767|ensembl:ENSP00000338020|ensembl:ENST00000382330|ensembl:ENSP00000371767|ensembl:ENST00000392537|ensembl:ENSP00000376320|ensembl:ENST00000414031|ensembl:ENSP00000391935|ensembl:ENST00000424196|ensembl:ENSP00000416255|ensembl:ENST00000434061|ensembl:ENSP00000411826|refseq:NP_886553.3|refseq:NP_937884.1|refseq:NP_937885.1|refseq:NP_004944.3|dip:DIP-1161N|ensembl:ENSG00000114867(gene)|ensembl:ENST00000346169(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016020"(membrane)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032502"(developmental process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097009"(energy homeostasis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905537"(positive regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905612"(positive regulation of mRNA cap binding)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1905696"(regulation of polysome binding)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037584|mint:Q04637|rcsb pdb:1LJ2|rcsb pdb:1UG3|rcsb pdb:2W97|rcsb pdb:4AZA|rcsb pdb:4F02|rcsb pdb:5EHC|rcsb pdb:5EI3|rcsb pdb:5EIR|rcsb pdb:5T46|rcsb pdb:6ZMW|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-166208|reactome:R-HSA-429947|reactome:R-HSA-450408|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957 interpro:IPR002873(Non-structural protein NSP3, Rotavirus)|interpro:IPR042519|interpro:IPR036082|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0030430"(host cell cytoplasm) - - - caution:Sequence length of Q00721 is 315, not 313 as stated in the paper, so deletion mutants have been reannoted to sequence as given.|figure legend:5 taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2007/06/13 2019/01/23 rogid:0UfVxxWOLUvrvFfcteeTc2RrbhA9606 rogid:8+WjY8janozUg7W4RSGd2hiy/yI36436 intact-crc:7BC62A637F99DB14|rigid:MCxoeoDN0ED3AmczqKowZcph14A false necessary binding region:120-142 sufficient binding region:88-315 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q04637 uniprotkb:Q9UGR2 intact:EBI-73711|uniprotkb:O43177|uniprotkb:O95066|uniprotkb:Q5HYG0|uniprotkb:Q6ZN21|uniprotkb:Q8N102|intact:EBI-11020102|uniprotkb:D3DNT4|uniprotkb:D3DNT5|uniprotkb:D3DNT2|uniprotkb:E9PFM1|uniprotkb:G5E9S1|intact:EBI-28974642|ensembl:ENSP00000316879 intact:EBI-948845|ensembl:ENSP00000345793|uniprotkb:Q5TFX9|uniprotkb:Q8TBT9|uniprotkb:Q9H8B6|uniprotkb:Q9UGQ9|uniprotkb:Q9UGR0|uniprotkb:Q9UGR1|uniprotkb:Q9UK03|uniprotkb:Q9UPW9|uniprotkb:A7YY88|uniprotkb:B2RCA4 psi-mi:if4g1_human(display_long)|uniprotkb:p220(gene name synonym)|uniprotkb:EIF4G1(gene name)|psi-mi:EIF4G1(display_short)|uniprotkb:EIF4G(gene name synonym)|uniprotkb:EIF4GI(gene name synonym)|uniprotkb:EIF4F(gene name synonym) psi-mi:z3h7b_human(display_long)|uniprotkb:Rotavirus 'X'-associated non-structural protein(gene name synonym)|uniprotkb:ZC3H7B(gene name)|psi-mi:ZC3H7B(display_short)|uniprotkb:KIAA1031(gene name synonym) psi-mi:"MI:0588"(three hybrid) Vitour et al. (2004) pubmed:15047801 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1264097 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000342981|ensembl:ENSP00000343450|ensembl:ENSP00000316879|ensembl:ENST00000350481|ensembl:ENSP00000317600|ensembl:ENST00000352767|ensembl:ENSP00000338020|ensembl:ENST00000382330|ensembl:ENSP00000371767|ensembl:ENST00000392537|ensembl:ENSP00000376320|ensembl:ENST00000414031|ensembl:ENSP00000391935|ensembl:ENST00000424196|ensembl:ENSP00000416255|ensembl:ENST00000434061|ensembl:ENSP00000411826|refseq:NP_886553.3|refseq:NP_937884.1|refseq:NP_937885.1|refseq:NP_004944.3|dip:DIP-1161N|ensembl:ENSG00000114867(gene)|ensembl:ENST00000346169(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016020"(membrane)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032502"(developmental process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097009"(energy homeostasis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905537"(positive regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905612"(positive regulation of mRNA cap binding)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1905696"(regulation of polysome binding)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037584|mint:Q04637|rcsb pdb:1LJ2|rcsb pdb:1UG3|rcsb pdb:2W97|rcsb pdb:4AZA|rcsb pdb:4F02|rcsb pdb:5EHC|rcsb pdb:5EI3|rcsb pdb:5EIR|rcsb pdb:5T46|rcsb pdb:6ZMW|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-166208|reactome:R-HSA-429947|reactome:R-HSA-450408|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957 ensembl:ENSG00000100403(gene)|ensembl:ENST00000352645(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036236|interpro:IPR036855|interpro:IPR039691|refseq:NP_060060.3 - - - caution:Sequence length of Q00721 is 315, not 313 as stated in the paper, so deletion mutants have been reannoted to sequence as given.|figure legend:5 taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2007/06/13 2019/01/23 rogid:0UfVxxWOLUvrvFfcteeTc2RrbhA9606 rogid:OoA5aL/8pJANSn6oKUqJsMWbAgY9606 intact-crc:7BC62A637F99DB14|rigid:MCxoeoDN0ED3AmczqKowZcph14A false necessary binding region:120-142 sufficient binding region:1-387 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q04637 uniprotkb:Q9UGR2 intact:EBI-73711|uniprotkb:O43177|uniprotkb:O95066|uniprotkb:Q5HYG0|uniprotkb:Q6ZN21|uniprotkb:Q8N102|intact:EBI-11020102|uniprotkb:D3DNT4|uniprotkb:D3DNT5|uniprotkb:D3DNT2|uniprotkb:E9PFM1|uniprotkb:G5E9S1|intact:EBI-28974642|ensembl:ENSP00000316879 intact:EBI-948845|ensembl:ENSP00000345793|uniprotkb:Q5TFX9|uniprotkb:Q8TBT9|uniprotkb:Q9H8B6|uniprotkb:Q9UGQ9|uniprotkb:Q9UGR0|uniprotkb:Q9UGR1|uniprotkb:Q9UK03|uniprotkb:Q9UPW9|uniprotkb:A7YY88|uniprotkb:B2RCA4 psi-mi:if4g1_human(display_long)|uniprotkb:p220(gene name synonym)|uniprotkb:EIF4G1(gene name)|psi-mi:EIF4G1(display_short)|uniprotkb:EIF4G(gene name synonym)|uniprotkb:EIF4GI(gene name synonym)|uniprotkb:EIF4F(gene name synonym) psi-mi:z3h7b_human(display_long)|uniprotkb:Rotavirus 'X'-associated non-structural protein(gene name synonym)|uniprotkb:ZC3H7B(gene name)|psi-mi:ZC3H7B(display_short)|uniprotkb:KIAA1031(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Vitour et al. (2004) pubmed:15047801 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1264171 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000342981|ensembl:ENSP00000343450|ensembl:ENSP00000316879|ensembl:ENST00000350481|ensembl:ENSP00000317600|ensembl:ENST00000352767|ensembl:ENSP00000338020|ensembl:ENST00000382330|ensembl:ENSP00000371767|ensembl:ENST00000392537|ensembl:ENSP00000376320|ensembl:ENST00000414031|ensembl:ENSP00000391935|ensembl:ENST00000424196|ensembl:ENSP00000416255|ensembl:ENST00000434061|ensembl:ENSP00000411826|refseq:NP_886553.3|refseq:NP_937884.1|refseq:NP_937885.1|refseq:NP_004944.3|dip:DIP-1161N|ensembl:ENSG00000114867(gene)|ensembl:ENST00000346169(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016020"(membrane)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032502"(developmental process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097009"(energy homeostasis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905537"(positive regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905612"(positive regulation of mRNA cap binding)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1905696"(regulation of polysome binding)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037584|mint:Q04637|rcsb pdb:1LJ2|rcsb pdb:1UG3|rcsb pdb:2W97|rcsb pdb:4AZA|rcsb pdb:4F02|rcsb pdb:5EHC|rcsb pdb:5EI3|rcsb pdb:5EIR|rcsb pdb:5T46|rcsb pdb:6ZMW|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-166208|reactome:R-HSA-429947|reactome:R-HSA-450408|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957 ensembl:ENSG00000100403(gene)|ensembl:ENST00000352645(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036236|interpro:IPR036855|interpro:IPR039691|refseq:NP_060060.3 - - - figure legend:6|comment:Interaction only occurs in virally infected cells, even when the human proteins are highly over-expressed. taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2007/06/13 2019/01/23 rogid:0UfVxxWOLUvrvFfcteeTc2RrbhA9606 rogid:OoA5aL/8pJANSn6oKUqJsMWbAgY9606 intact-crc:646E7EF26BE9303C|rigid:vHU/qNEOPgN2Pmm1ypruHR3eZPs false - t7 tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)