#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P50213	uniprotkb:P51553	intact:EBI-355999|uniprotkb:D3DW83|uniprotkb:Q9H3X0|ensembl:ENSP00000299518	intact:EBI-1210876|uniprotkb:Q9BUU5|uniprotkb:E9PDD5|ensembl:ENSP00000217901	psi-mi:idh3a_human(display_long)|uniprotkb:IDH3A(gene name)|psi-mi:IDH3A(display_short)|uniprotkb:Isocitric dehydrogenase subunit alpha(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit alpha"(gene name synonym)	psi-mi:idh3g_human(display_long)|uniprotkb:IDH3G(gene name)|psi-mi:IDH3G(display_short)|uniprotkb:Isocitric dehydrogenase subunit gamma(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit gamma"(gene name synonym)	psi-mi:"MI:0226"(ion exchange chromatography)	Soundar et al. (2003)	pubmed:14555658|imex:IM-19941	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1210893|imex:IM-19941-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005521.1|interpro:IPR024084|ensembl:ENSG00000166411(gene)|ensembl:ENST00000299518(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|mint:P50213|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6KDE|rcsb pdb:6KDF|rcsb pdb:6KDY|rcsb pdb:6KE3|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-71403	refseq:NP_004126.1|refseq:NP_777358.1|ensembl:ENSG00000067829(gene)|ensembl:ENST00000217901(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|interpro:IPR024084|mint:P51553|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-1268020|reactome:R-HSA-71403	go:"GO:0005962"("mitochondrial isocitrate dehydrogenase complex (NAD+)")	-	-	figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2007/03/06	2014/10/16	rogid:JvAUAMJ0DcgnIfvy/vlfRyXYzhE9606	rogid:CQ3xfzDzQreBvU2mRPSg5xUfjKY9606	intact-crc:8BD961F625D05550|rigid:z/QDnCCKFQzZ6BxsPt0bsnAmwY8	false	-	-	-	-	psi-mi:"MI:0039"(edman degradation)	psi-mi:"MI:0039"(edman degradation)
uniprotkb:P50213	uniprotkb:O43837-2	intact:EBI-355999|uniprotkb:D3DW83|uniprotkb:Q9H3X0|ensembl:ENSP00000299518	intact:EBI-725399|ensembl:ENSP00000370232	psi-mi:idh3a_human(display_long)|uniprotkb:IDH3A(gene name)|psi-mi:IDH3A(display_short)|uniprotkb:Isocitric dehydrogenase subunit alpha(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit alpha"(gene name synonym)	psi-mi:o43837-2(display_long)|uniprotkb:IDH3B(gene name)|psi-mi:IDH3B(display_short)|uniprotkb:Isocitric dehydrogenase subunit beta(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit beta"(gene name synonym)	psi-mi:"MI:0226"(ion exchange chromatography)	Soundar et al. (2003)	pubmed:14555658|imex:IM-19941	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1210893|imex:IM-19941-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005521.1|interpro:IPR024084|ensembl:ENSG00000166411(gene)|ensembl:ENST00000299518(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|mint:P50213|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6KDE|rcsb pdb:6KDF|rcsb pdb:6KDY|rcsb pdb:6KE3|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-71403	intact:EBI-725377(idh3b_human)|ensembl:ENST00000380851(transcript)|ensembl:ENSG00000101365(gene)|uniprotkb:O43837-2(isoform-parent)	go:"GO:0005962"("mitochondrial isocitrate dehydrogenase complex (NAD+)")	-	-	figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2007/03/06	2014/10/16	rogid:JvAUAMJ0DcgnIfvy/vlfRyXYzhE9606	rogid:MogbvdEMgzFrE+7kl0ndsuXXIeo9606	intact-crc:8BD961F625D05550|rigid:z/QDnCCKFQzZ6BxsPt0bsnAmwY8	false	-	-	-	-	psi-mi:"MI:0039"(edman degradation)	psi-mi:"MI:0039"(edman degradation)
uniprotkb:P50213	uniprotkb:P51553	intact:EBI-355999|uniprotkb:D3DW83|uniprotkb:Q9H3X0|ensembl:ENSP00000299518	intact:EBI-1210876|uniprotkb:Q9BUU5|uniprotkb:E9PDD5|ensembl:ENSP00000217901	psi-mi:idh3a_human(display_long)|uniprotkb:IDH3A(gene name)|psi-mi:IDH3A(display_short)|uniprotkb:Isocitric dehydrogenase subunit alpha(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit alpha"(gene name synonym)	psi-mi:idh3g_human(display_long)|uniprotkb:IDH3G(gene name)|psi-mi:IDH3G(display_short)|uniprotkb:Isocitric dehydrogenase subunit gamma(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit gamma"(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Soundar et al. (2003)	pubmed:14555658|imex:IM-19941	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1210907|imex:IM-19941-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005521.1|interpro:IPR024084|ensembl:ENSG00000166411(gene)|ensembl:ENST00000299518(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|mint:P50213|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6KDE|rcsb pdb:6KDF|rcsb pdb:6KDY|rcsb pdb:6KE3|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-71403	refseq:NP_004126.1|refseq:NP_777358.1|ensembl:ENSG00000067829(gene)|ensembl:ENST00000217901(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|interpro:IPR024084|mint:P51553|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-1268020|reactome:R-HSA-71403	go:"GO:0005962"("mitochondrial isocitrate dehydrogenase complex (NAD+)")	-	-	figure legend:3|complex-properties:Molecular mass of the complex is approximately 315kDa, indicating an octomer.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2007/03/06	2014/10/16	rogid:JvAUAMJ0DcgnIfvy/vlfRyXYzhE9606	rogid:CQ3xfzDzQreBvU2mRPSg5xUfjKY9606	intact-crc:94D4B2E70176A878|rigid:z/QDnCCKFQzZ6BxsPt0bsnAmwY8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50213	uniprotkb:O43837-2	intact:EBI-355999|uniprotkb:D3DW83|uniprotkb:Q9H3X0|ensembl:ENSP00000299518	intact:EBI-725399|ensembl:ENSP00000370232	psi-mi:idh3a_human(display_long)|uniprotkb:IDH3A(gene name)|psi-mi:IDH3A(display_short)|uniprotkb:Isocitric dehydrogenase subunit alpha(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit alpha"(gene name synonym)	psi-mi:o43837-2(display_long)|uniprotkb:IDH3B(gene name)|psi-mi:IDH3B(display_short)|uniprotkb:Isocitric dehydrogenase subunit beta(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit beta"(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Soundar et al. (2003)	pubmed:14555658|imex:IM-19941	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1210907|imex:IM-19941-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005521.1|interpro:IPR024084|ensembl:ENSG00000166411(gene)|ensembl:ENST00000299518(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|mint:P50213|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6KDE|rcsb pdb:6KDF|rcsb pdb:6KDY|rcsb pdb:6KE3|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-71403	intact:EBI-725377(idh3b_human)|ensembl:ENST00000380851(transcript)|ensembl:ENSG00000101365(gene)|uniprotkb:O43837-2(isoform-parent)	go:"GO:0005962"("mitochondrial isocitrate dehydrogenase complex (NAD+)")	-	-	figure legend:3|complex-properties:Molecular mass of the complex is approximately 315kDa, indicating an octomer.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2007/03/06	2014/10/16	rogid:JvAUAMJ0DcgnIfvy/vlfRyXYzhE9606	rogid:MogbvdEMgzFrE+7kl0ndsuXXIeo9606	intact-crc:94D4B2E70176A878|rigid:z/QDnCCKFQzZ6BxsPt0bsnAmwY8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50213	uniprotkb:P51553	intact:EBI-355999|uniprotkb:D3DW83|uniprotkb:Q9H3X0|ensembl:ENSP00000299518	intact:EBI-1210876|uniprotkb:Q9BUU5|uniprotkb:E9PDD5|ensembl:ENSP00000217901	psi-mi:idh3a_human(display_long)|uniprotkb:IDH3A(gene name)|psi-mi:IDH3A(display_short)|uniprotkb:Isocitric dehydrogenase subunit alpha(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit alpha"(gene name synonym)	psi-mi:idh3g_human(display_long)|uniprotkb:IDH3G(gene name)|psi-mi:IDH3G(display_short)|uniprotkb:Isocitric dehydrogenase subunit gamma(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit gamma"(gene name synonym)	psi-mi:"MI:0227"(reverse phase chromatography)	Soundar et al. (2003)	pubmed:14555658|imex:IM-19941	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1210952|imex:IM-19941-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005521.1|interpro:IPR024084|ensembl:ENSG00000166411(gene)|ensembl:ENST00000299518(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|mint:P50213|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6KDE|rcsb pdb:6KDF|rcsb pdb:6KDY|rcsb pdb:6KE3|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-71403	refseq:NP_004126.1|refseq:NP_777358.1|ensembl:ENSG00000067829(gene)|ensembl:ENST00000217901(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|interpro:IPR024084|mint:P51553|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-1268020|reactome:R-HSA-71403	go:"GO:0005962"("mitochondrial isocitrate dehydrogenase complex (NAD+)")	-	-	figure legend:4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2007/03/06	2014/10/16	rogid:JvAUAMJ0DcgnIfvy/vlfRyXYzhE9606	rogid:CQ3xfzDzQreBvU2mRPSg5xUfjKY9606	intact-crc:D918D3A8A9122F71|rigid:z/QDnCCKFQzZ6BxsPt0bsnAmwY8	false	-	-	2	1	psi-mi:"MI:0039"(edman degradation)	psi-mi:"MI:0039"(edman degradation)
uniprotkb:P50213	uniprotkb:O43837-2	intact:EBI-355999|uniprotkb:D3DW83|uniprotkb:Q9H3X0|ensembl:ENSP00000299518	intact:EBI-725399|ensembl:ENSP00000370232	psi-mi:idh3a_human(display_long)|uniprotkb:IDH3A(gene name)|psi-mi:IDH3A(display_short)|uniprotkb:Isocitric dehydrogenase subunit alpha(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit alpha"(gene name synonym)	psi-mi:o43837-2(display_long)|uniprotkb:IDH3B(gene name)|psi-mi:IDH3B(display_short)|uniprotkb:Isocitric dehydrogenase subunit beta(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit beta"(gene name synonym)	psi-mi:"MI:0227"(reverse phase chromatography)	Soundar et al. (2003)	pubmed:14555658|imex:IM-19941	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1210952|imex:IM-19941-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005521.1|interpro:IPR024084|ensembl:ENSG00000166411(gene)|ensembl:ENST00000299518(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|mint:P50213|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6KDE|rcsb pdb:6KDF|rcsb pdb:6KDY|rcsb pdb:6KE3|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-71403	intact:EBI-725377(idh3b_human)|ensembl:ENST00000380851(transcript)|ensembl:ENSG00000101365(gene)|uniprotkb:O43837-2(isoform-parent)	go:"GO:0005962"("mitochondrial isocitrate dehydrogenase complex (NAD+)")	-	-	figure legend:4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2007/03/06	2014/10/16	rogid:JvAUAMJ0DcgnIfvy/vlfRyXYzhE9606	rogid:MogbvdEMgzFrE+7kl0ndsuXXIeo9606	intact-crc:D918D3A8A9122F71|rigid:z/QDnCCKFQzZ6BxsPt0bsnAmwY8	false	-	-	2	1	psi-mi:"MI:0039"(edman degradation)	psi-mi:"MI:0039"(edman degradation)
chebi:"CHEBI:16761"	uniprotkb:P50213	intact:EBI-1188073	intact:EBI-355999|uniprotkb:D3DW83|uniprotkb:Q9H3X0|ensembl:ENSP00000299518	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:idh3a_human(display_long)|uniprotkb:IDH3A(gene name)|psi-mi:IDH3A(display_short)|uniprotkb:Isocitric dehydrogenase subunit alpha(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit alpha"(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Soundar et al. (2003)	pubmed:14555658|imex:IM-19941	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1210967|imex:IM-19941-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005521.1|interpro:IPR024084|ensembl:ENSG00000166411(gene)|ensembl:ENST00000299518(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|mint:P50213|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6KDE|rcsb pdb:6KDF|rcsb pdb:6KDY|rcsb pdb:6KE3|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-71403	go:"GO:0005962"("mitochondrial isocitrate dehydrogenase complex (NAD+)")	-	-	figure legend:Table 4|comment:The dissociation constant for enzyme-ADP is 15.9, 73.4, 234, and 513uM for wild type, alpha-R115, beta-R133Q, and gamma-R136Q enzymes, respectively.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2007/03/06	2014/10/16	-	rogid:JvAUAMJ0DcgnIfvy/vlfRyXYzhE9606	intact-crc:B7E0CBBAC14263FF	false	-	mutation decreasing interaction:115-115	-	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	uniprotkb:P51553	intact:EBI-1188073	intact:EBI-1210876|uniprotkb:Q9BUU5|uniprotkb:E9PDD5|ensembl:ENSP00000217901	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:idh3g_human(display_long)|uniprotkb:IDH3G(gene name)|psi-mi:IDH3G(display_short)|uniprotkb:Isocitric dehydrogenase subunit gamma(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit gamma"(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Soundar et al. (2003)	pubmed:14555658|imex:IM-19941	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1210967|imex:IM-19941-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004126.1|refseq:NP_777358.1|ensembl:ENSG00000067829(gene)|ensembl:ENST00000217901(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|interpro:IPR024084|mint:P51553|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-1268020|reactome:R-HSA-71403	go:"GO:0005962"("mitochondrial isocitrate dehydrogenase complex (NAD+)")	-	-	figure legend:Table 4|comment:The dissociation constant for enzyme-ADP is 15.9, 73.4, 234, and 513uM for wild type, alpha-R115, beta-R133Q, and gamma-R136Q enzymes, respectively.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2007/03/06	2014/10/16	-	rogid:CQ3xfzDzQreBvU2mRPSg5xUfjKY9606	intact-crc:B7E0CBBAC14263FF	false	-	mutation decreasing interaction:136-136	-	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	uniprotkb:O43837-2	intact:EBI-1188073	intact:EBI-725399|ensembl:ENSP00000370232	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:o43837-2(display_long)|uniprotkb:IDH3B(gene name)|psi-mi:IDH3B(display_short)|uniprotkb:Isocitric dehydrogenase subunit beta(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit beta"(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Soundar et al. (2003)	pubmed:14555658|imex:IM-19941	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1210967|imex:IM-19941-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-725377(idh3b_human)|ensembl:ENST00000380851(transcript)|ensembl:ENSG00000101365(gene)|uniprotkb:O43837-2(isoform-parent)	go:"GO:0005962"("mitochondrial isocitrate dehydrogenase complex (NAD+)")	-	-	figure legend:Table 4|comment:The dissociation constant for enzyme-ADP is 15.9, 73.4, 234, and 513uM for wild type, alpha-R115, beta-R133Q, and gamma-R136Q enzymes, respectively.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2007/03/06	2014/10/16	-	rogid:MogbvdEMgzFrE+7kl0ndsuXXIeo9606	intact-crc:B7E0CBBAC14263FF	false	-	mutation decreasing interaction:133-133	-	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)